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Relevant bibliographies by topics / Myší střevní epitel

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Dissertations / Theses

Academic literature on the topic 'Myší střevní epitel'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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Dissertations / Theses on the topic "Myší střevní epitel"

1

Janečková, Lucie. "Signální dráha Wnt v obnově a tumorigenezi střevního epitelu." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-338480.

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The canonical Wnt signaling pathway is one of the most important pathways involved in cell proliferation and differentiation. It is highly conserved in evolution and participates not only in embryonic development but also in adult tissue homeostasis. In the intestine, Wnt signaling is closely connected to maintenance of intestinal stem cells and renewal of the epithelia. Conversely, aberrant activation of the Wnt signaling pathway underlies different types of human diseases. Its constitutive activation results in neoplasia and specifically in development of colorectal cancer, which is the thir

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2

Baloghová, Nikol. "Charakterizace nádorového supresoru Hypermethylated in cancer 1 (Hic1) a jeho nových cílových genů v rámci střevního epitelu a rakoviny střeva." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-351480.

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Colorectal cancer is one of the most common cancer types worldwide. Both genetic and epigenetic alterations play a critical role in its initiation and progression. One of the genes frequently epigenetically silenced or lost in many types of human cancer is tumor suppressor gene Hypermethylated in Cancer 1 (HIC1). It encodes for transcriptional repressor regulating its target genes directly or indirectly. Twelve genes whose expression is repressed by HIC1 have been identified to date. These genes encode for transcription factors, cell cycle and apoptosis regulators or proteins involved in angio

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3

Burešová, Petra. "Morfologická a funkční charakterizace střevního epitelu z hlediska exprese proteinu LGR4." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-355979.

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4

Hrčkulák, Dušan. "Funkce a regulace transkripčních faktorů ETV4 a MSX1 v rozvoji rakoviny tlustého střeva." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-332150.

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Colon cancer causes approximately seven percent of all cancer-related deaths in the world and presumably due to modern lifestyle, it is also one of the most frequently diagnosed cancers. The inefficiency of standard treatment indicates the need for intensive research of molecular mechanisms of cancer development. The canonical Wnt signaling pathway is essential for maintenance of the progenitor phenotype of stem cells in crypts of the intestine and controls repopulation of the epithelia, in physiological conditions. However, aberrant activation leads to tumor formation. Although Wnt signaling

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5

Du, Zhengyu. "Úloha bakterií,mukózního imunitního syst=ému a jejich interakce v patogenezi zánětlivých střevních onemocnění." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-267797.

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Although the etiology and pathogenesis of inflammatory bowel disease (IBD) is not fully understood, it is generally accepted that the inflammation results from aberrant immune responses to antigens of gut microbiota in genetically susceptible individuals (Sartor et al., 2006). Alteration in intestinal microbiota has been found in IBD patients with increased abundance of certain bacteria and decreased abundance of others. Due to the complexity of the disease, multifaceted interactions between genetic factors, host immune response, gut microbiota and environment factors need to be taken into acc

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