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Relevant bibliographies by topics / Myxovirus Resistance Proteins

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Dissertations / Theses
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Academic literature on the topic 'Myxovirus Resistance Proteins'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "Myxovirus Resistance Proteins"

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Goujon, Caroline, Rebecca A. Greenbury, Stelios Papaioannou, Tomas Doyle, and Michael H. Malim. "A Triple-Arginine Motif in the Amino-Terminal Domain and Oligomerization Are Required for HIV-1 Inhibition by Human MX2." Journal of Virology 89, no. 8 (2015): 4676–80. http://dx.doi.org/10.1128/jvi.00169-15.

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We have employed molecular genetic approaches to understand the domain organization of the HIV-1 resistance factor myxovirus resistance 2 (MX2). First, we describe an essential triple-arginine motif in the amino-terminal domain. Second, we demonstrate that this 91-residue domain mediates antiviral activity when appended to heterologous proteins, and we provide genetic evidence that protein oligomerization is required for MX2 function. These insights will facilitate future work aiming to elucidate MX2's mechanism of action.

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Zav'yalov, Vladimir P., Heli Hämäläinen-Laanaya, Timo K. Korpela, and Tony Wahlroos. "Interferon-Inducible Myxovirus Resistance Proteins: Potential Biomarkers for Differentiating Viral from Bacterial Infections." Clinical Chemistry 65, no. 6 (2019): 739–50. http://dx.doi.org/10.1373/clinchem.2018.292391.

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Abstract BACKGROUND In 2015, the 68th World Health Assembly declared that effective, rapid, low-cost diagnostic tools were needed for guiding optimal use of antibiotics in medicine. This review is devoted to interferon-inducible myxovirus resistance proteins as potential biomarkers for differentiating viral from bacterial infections. CONTENT After viral infection, a branch of the interferon (IFN)-induced molecular reactions is triggered by the binding of IFNs with their receptors, a process leading to the activation of mx1 and mx2, which produce antiviral Mx proteins (MxA and MxB). We summariz

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Zhao, Chunfang, Shuqin Chen, Yujiao Han, et al. "Proteomic Analysis of Rat Duodenum Reveals the Modulatory Effect of Boron Supplementation on Immune Activity." Genes 14, no. 8 (2023): 1560. http://dx.doi.org/10.3390/genes14081560.

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The proper supplementation of boron, an essential trace element, can enhance animal immune function. We utilized the method of TMT peptide labeling in conjunction with LC-MS/MS quantitative proteomics for the purpose of examining the effects of boric acid on a rat model and analyzing proteins from the duodenum. In total, 5594 proteins were obtained from the 0, 10, and 320 mg/L boron treatment groups. Two hundred eighty-four proteins that exhibit differential expression were detected. Among the comparison, groups of 0 vs. 10 mg/L, 0 vs. 320 mg/L, and 10 vs. 320 mg/L of boron, 110, 32, and 179 p

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Betancor, Gilberto. "You Shall Not Pass: MX2 Proteins Are Versatile Viral Inhibitors." Vaccines 11, no. 5 (2023): 930. http://dx.doi.org/10.3390/vaccines11050930.

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Myxovirus resistance (MX) proteins are pivotal players in the innate immune response to viral infections. Less than 10 years ago, three independent groups simultaneously showed that human MX2 is an interferon (IFN)-stimulated gene (ISG) with potent anti-human immunodeficiency virus 1 (HIV-1) activity. Thenceforth, multiple research works have been published highlighting the ability of MX2 to inhibit RNA and DNA viruses. These growing bodies of evidence have identified some of the key determinants regulating its antiviral activity. Therefore, the importance of the protein amino-terminal domain,

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Braun, Benjamin A., Amir Marcovitz, J. Gray Camp, Robin Jia, and Gill Bejerano. "Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales." Proceedings of the National Academy of Sciences 112, no. 26 (2015): 8036–40. http://dx.doi.org/10.1073/pnas.1501844112.

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Viral outbreaks in dolphins and otherDelphinoideafamily members warrant investigation into the integrity of the cetacean immune system. The dynamin-like GTPase genes Myxovirus 1 (Mx1) andMx2defend mammals against a broad range of viral infections. Loss of Mx1 function in human and mice enhances infectivity by multiple RNA and DNA viruses, including orthomyxoviruses (influenza A), paramyxoviruses (measles), and hepadnaviruses (hepatitis B), whereas loss of Mx2 function leads to decreased resistance to HIV-1 and other viruses. Here we show that bothMx1andMx2have been rendered nonfunctional inOdo

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Huang, Yu, Fengwen Xu, Shan Mei, et al. "MxB inhibits long interspersed element type 1 retrotransposition." PLOS Genetics 18, no. 2 (2022): e1010034. http://dx.doi.org/10.1371/journal.pgen.1010034.

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Long interspersed element type 1 (LINE-1, also L1 for short) is the only autonomously transposable element in the human genome. Its insertion into a new genomic site may disrupt the function of genes, potentially causing genetic diseases. Cells have thus evolved a battery of mechanisms to tightly control LINE-1 activity. Here, we report that a cellular antiviral protein, myxovirus resistance protein B (MxB), restricts the mobilization of LINE-1. This function of MxB requires the nuclear localization signal located at its N-terminus, its GTPase activity and its ability to form oligomers. We fur

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Unoshima, Masako, Hideo Iwasaka, Junko Eto, Yoshiko Takita-Sonoda, Takayuki Noguchi, and Akira Nishizono. "Antiviral Effects of Geranylgeranylacetone: Enhancement of MxA Expression and Phosphorylation of PKR during Influenza Virus Infection." Antimicrobial Agents and Chemotherapy 47, no. 9 (2003): 2914–21. http://dx.doi.org/10.1128/aac.47.9.2914-2921.2003.

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ABSTRACT A cyclic polyisoprenoid compound, geranylgeranylacetone (GGA), has been used as antiulcer drug. GGA is also a potent inducer of heat shock proteins (HSPs). HSPs are considered to induce an antiviral effect; however, the detailed mechanism is unknown. To determine whether GGA might show antiviral activity and what the mechanism is, the effect of GGA against influenza virus (strain PR8) infection in vivo and in vitro was investigated. The results demonstrated that GGA treatment strongly suppressed the deleterious consequences of PR8 replication and was accompanied by an increase in HSP7

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Fatima, Urooj, Zhenyu Zhang, Haili Zhang, et al. "Equine Mx1 Restricts Influenza A Virus Replication by Targeting at Distinct Site of its Nucleoprotein." Viruses 11, no. 12 (2019): 1114. http://dx.doi.org/10.3390/v11121114.

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Interferon-mediated host factors myxovirus (Mx) proteins are key features in regulating influenza A virus (IAV) infections. Viral polymerases are essential for viral replication. The Mx1 protein has been known to interact with viral nucleoprotein (NP) and PB2, resulting in the influence of polymerase activity and providing interspecies restriction. The equine influenza virus has evolved as an independent lineage to influenza viruses from other species. We estimated the differences in antiviral activities between human MxA (huMxA) and equine Mx1 (eqMx1) against a broad range of IAV strains. We

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Arianmanesh, Mitra, Rebecca H. McIntosh, Richard G. Lea, Paul A. Fowler, and Kaïs H. Al-Gubory. "Ovine corpus luteum proteins, with functions including oxidative stress and lipid metabolism, show complex alterations during implantation." Journal of Endocrinology 210, no. 1 (2011): 47–58. http://dx.doi.org/10.1530/joe-10-0336.

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Progesterone (P4) secreted by the corpus luteum (CL) is critical for in utero embryo survival and development, although CL proteins are key regulatory factors during the luteal phase. We, therefore, characterised protein expression patterns in ovine CL of pregnancy (days 12, 16 and 20) compared with those of controls, CL of oestrous cycle (days 12 and 16), using two-dimensional gel electrophoresis (2DE) gel-based proteomics. Proteins in 24 significantly altered spots were identified by tandem mass spectroscopy. At the time of embryo implantation (day 16), 77 spots were up-regulated and 101 spo

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Jo, Bo-Ram, Hyun-Soo Kim, Jeong-Won Ahn, et al. "A Novel Antiviral Protein Derived from Oenanthe javanica: Type I Interferon-Dependent Antiviral Signaling and Its Pharmacological Potential." Biomolecules 12, no. 6 (2022): 835. http://dx.doi.org/10.3390/biom12060835.

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Pathogenesis-related (PR) proteins produced in plants play a crucial role in self-defense against microbial attacks. Previously, we have identified a novel PR-1-like protein (OPRP) from Oenanthe javanica and examined its pharmacologic relevance and cell signaling in mammalian cells. Purified full-length OPRP protein significantly increased toll-like receptor 4 (TLR4)-dependent expression levels of genes such as inducible nitric oxide synthase (iNOS), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and CD80. We also found that small peptides (OPRP2 and OPRP3) designed from OPRP remarkabl

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Dissertations / Theses on the topic "Myxovirus Resistance Proteins"

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Hoff, Florian [Verfasser], and Ralf [Akademischer Betreuer] Jacob. "Charakterisierung der großen GTPase Myxovirus Resistance Protein 1 (Mx1) im intrazellulären Proteintransport / Florian Hoff. Betreuer: Ralf Jacob." Marburg : Philipps-Universität Marburg, 2015. http://d-nb.info/1080299076/34.

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Book chapters on the topic "Myxovirus Resistance Proteins"

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Milone, Margherita, and Teerin Liewluck. "Progressive Weakness and Rash." In Mayo Clinic Cases in Neuroimmunology, edited by Andrew McKeon, B. Mark Keegan, and W. Oliver Tobin. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0050.

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A 47-year-old man with hypercholesterolemia sought care for a 4-month history of progressive, proximal upper limb weakness and myalgia, followed by dysphagia, difficulty climbing stairs, and facial rash. Discontinuation of atorvastatin was of no benefit. Neurologic examination showed moderate weakness of the neck flexor muscles, shoulder girdle muscles, and finger extensors, and mild weakness of hip flexor and ankle dorsiflexor muscles. He had a heliotrope rash and Gottron sign. Serum testing showed an increased creatine kinase level. Needle electromyography showed myopathic changes with fibri

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Conference papers on the topic "Myxovirus Resistance Proteins"

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Chompoopong, Pitcha, Michael Skolka, Floranne Ernste, and Teerin Liewluck. "Symptomatic Myopathies in Sarcoidosis: Disease Spectrum and Myxovirus Resistance Protein A (MxA) Expression (S7.002)." In 2023 Annual Meeting Abstracts. Lippincott Williams & Wilkins, 2023. http://dx.doi.org/10.1212/wnl.0000000000202748.

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Lambers, Wietske M., Gilles FH Diercks, Femke M. Homan, et al. "P27 Myxovirus resistance protein A is a useful additional histological marker for cutaneous lupus erythematosus." In 12th European Lupus Meeting. Lupus Foundation of America, 2020. http://dx.doi.org/10.1136/lupus-2020-eurolupus.75.

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Lambers, W., H. Westra, B. Doornbos-van der Meer, M. Jonkman, H. Bootsma, and K. de Leeuw. "OP0175 Interferon signature might serve as early biomarker for development of lupus and correlates strongly with myxovirus-resistance protein a." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.3410.

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