Academic literature on the topic 'Nω-propyl-l-arginine'

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Journal articles on the topic "Nω-propyl-l-arginine"

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Gowda, Charan, Glen A. Toomayan, Wen-Ning Qi та ін. "The effects of Nω-propyl-l-arginine on reperfusion injury of skeletal muscle". Nitric Oxide 11, № 1 (2004): 17–24. http://dx.doi.org/10.1016/j.niox.2004.07.007.

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Ok, Seong-Ho, Jeong Yeol Han, Hui-Jin Sung, et al. "Ropivacaine-Induced Contraction Is Attenuated by Both Endothelial Nitric Oxide and Voltage-Dependent Potassium Channels in Isolated Rat Aortae." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/565271.

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This study investigated endothelium-derived vasodilators and potassium channels involved in the modulation of ropivacaine-induced contraction. In endothelium-intact rat aortae, ropivacaine concentration-response curves were generated in the presence or absence of the following inhibitors: the nonspecific nitric oxide synthase (NOS) inhibitorNω-nitro-L-arginine methyl ester (L-NAME), the neuronal NOS inhibitorNω-propyl-L-arginine hydrochloride, the inducible NOS inhibitor 1400W dihydrochloride, the nitric oxide-sensitive guanylyl cyclase (GC) inhibitor ODQ, the NOS and GC inhibitor methylene bl
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Lekontseva, Olga, Yanyan Jiang, Caitlyn Schleppe, and Sandra T. Davidge. "Altered Neuronal Nitric Oxide Synthase in the Aging Vascular System: Implications for Estrogens Therapy." Endocrinology 153, no. 8 (2012): 3940–48. http://dx.doi.org/10.1210/en.2012-1071.

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Ovarian dysfunction at any age is associated with increased cardiovascular risk in women; however, therapeutic effects of exogenous estrogens are age dependent. Estradiol (E2) activates neuronal nitric oxide synthase (nNOS) in vascular cells. Because nNOS is prone to uncoupling under unfavorable biochemical conditions (as seen in aging), E2 stimulation of nNOS may lack vascular benefits in aging. Small mesenteric arteries were isolated from female Sprague Dawley rats, 3 or 12 months old, who were ovariectomized (Ovx) and treated with placebo or E2 for 4 wk. Vascular relaxation to exogenous E2
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Carlström, Mattias, Christopher S. Wilcox, and William J. Welch. "Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase." American Journal of Physiology-Renal Physiology 300, no. 2 (2011): F457—F464. http://dx.doi.org/10.1152/ajprenal.00567.2010.

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Adenosine A2 receptors have been suggested to modulate tubuloglomerular feedback (TGF) responses by counteracting adenosine A1 receptor-mediated vasoconstriction, but the mechanisms are unclear. We tested the hypothesis that A2A receptor activation blunts TGF by release of nitric oxide in the juxtaglomerular apparatus (JGA). Maximal TGF responses were measured in male Sprague-Dawley rats as changes in proximal stop-flow pressure (ΔPSF) in response to increased perfusion of the loop of Henle (0 to 40 nl/min) with artificial tubular fluid (ATF). The maximal TGF response was studied after 5 min i
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Gomes-de-Souza, Lucas, Willian Costa-Ferreira, Leandro A. Oliveira, Ricardo Benini, and Carlos C. Crestani. "Cannabinoid receptor type 1 in the bed nucleus of the stria terminalis modulates cardiovascular responses to stress via local N-methyl-D-aspartate receptor/neuronal nitric oxide synthase/soluble guanylate cyclase/protein kinase G signaling." Journal of Psychopharmacology 34, no. 4 (2020): 429–40. http://dx.doi.org/10.1177/0269881119897556.

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Background: Endocannabinoid neurotransmission in the bed nucleus of the stria terminalis is involved in the control of cardiovascular responses to stress. However, the local mechanisms involved is this regulation are not known. Aims: The purpose of this study was to assess an interaction of bed nucleus of the stria terminalis endocannabinoid neurotransmission with local nitrergic signaling, as well as to investigate the involvement of local N-methyl-D-aspartate glutamate receptor and nitric oxide signaling in the control of cardiovascular responses to acute restraint stress by bed nucleus of t
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Kellogg, Dean L., Joan L. Zhao, and Yubo Wu. "Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans." Journal of Applied Physiology 107, no. 5 (2009): 1438–44. http://dx.doi.org/10.1152/japplphysiol.00690.2009.

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Nitric oxide (NO) participates in the cutaneous vasodilation caused by increased local skin temperature (Tloc) and whole body heat stress in humans. In forearm skin, endothelial NO synthase (eNOS) participates in vasodilation due to elevated Tloc and neuronal NO synthase (nNOS) participates in vasodilation due to heat stress. To explore the relative roles and interactions of these isoforms, we examined the effects of a relatively specific eNOS inhibitor, Nω-amino-l-arginine (LNAA), and a specific nNOS inhibitor, Nω-propyl-l-arginine (NPLA), both separately and in combination, on skin blood flo
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Klamer, Daniel, Jörgen A. Engel та Lennart Svensson. "The neuronal selective nitric oxide synthase inhibitor, Nω-propyl-l-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice". European Journal of Pharmacology 503, № 1-3 (2004): 103–7. http://dx.doi.org/10.1016/j.ejphar.2004.09.042.

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Bruning, Rebecca S., Lakshmi Santhanam, Anna E. Stanhewicz, et al. "Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin." Journal of Applied Physiology 112, no. 12 (2012): 2019–26. http://dx.doi.org/10.1152/japplphysiol.01354.2011.

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Local skin heating is used to assess microvascular function in clinical populations because NO is required for full expression of the response; however, controversy exists as to the precise NO synthase (NOS) isoform producing NO. Human aging is associated with attenuated cutaneous vasodilation but little is known about the middle aged, an age cohort used for comparison with clinical populations. We hypothesized that endothelial NOS (eNOS) is the primary isoform mediating NO production during local heating, and eNOS-dependent vasodilation would be reduced in middle-aged skin. Vasodilation was i
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Banwait, Kuldip S., та Satish Rattan. "Role of nitric oxide in β3-adrenoceptor activation on basal tone of internal anal sphincter". American Journal of Physiology-Gastrointestinal and Liver Physiology 285, № 3 (2003): G547—G555. http://dx.doi.org/10.1152/ajpgi.00545.2002.

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Effects of activation of β3-adrenoceptor (β3-AR) have not been determined in the spontaneously tonic smooth muscle of the internal anal sphincter (IAS). The effects of disodium (R,R)-5-[2-[2-3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316243), a selective β3-AR agonist, on the basal smooth muscle tone and direct release of nitric oxide (NO) by circular smooth muscle strips of the opossum IAS were determined. We also examined the presence of endothelial nitric oxide synthase (eNOS) protein by Western blot studies. CL 316243 produced a concentration-depen
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Stanhewicz, Anna E., Jody L. Greaney, W. Larry Kenney, and Lacy M. Alexander. "Sex- and limb-specific differences in the nitric oxide-dependent cutaneous vasodilation in response to local heating." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307, no. 7 (2014): R914—R919. http://dx.doi.org/10.1152/ajpregu.00269.2014.

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Local heating of the skin is commonly used to assess cutaneous microvasculature function. Controversy exists as to whether there are limb or sex differences in the nitric oxide (NO)-dependent contribution to this vasodilation, as well as the NO synthase (NOS) isoform mediating the responses. We tested the hypotheses that 1) NO-dependent vasodilation would be greater in the calf compared with the forearm; 2) total NO-dependent dilation would not be different between sexes within limb; and 3) women would exhibit greater neuronal NOS (nNOS)-dependent vasodilation in the calf. Two microdialysis fi
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Dissertations / Theses on the topic "Nω-propyl-l-arginine"

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Dobrovodská, Gabriela. "Oxid dusnatý a jeho neurofyziologická role." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-310899.

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Title: Nitric oxide and its neurophysiologic role Objectives: The main aim of my diploma work is to evaluate the role of nitric oxide and its effects during epileptic seizure in rats. I summarize the present knowledge about nitric oxide and its effects on human organism in the theoretical section of this paper and I will suppose the positive effect of nitric oxide inhibitor in epileptic seizures in rats by the realization of my experiment. Methods: The experiment will be performed in the laboratory of Academy of Science of Czech Republic. Implementation will come through examining a set of ten
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