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Journal articles on the topic 'N-(2-hydroxy phenyl) acetamide'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Girel, Sergey, Vadim Schütz, Laurent Bigler, Peter Dörmann, and Margot Schulz. "Bioactive Nitrosylated and Nitrated N-(2-hydroxyphenyl)acetamides and Derived Oligomers: An Alternative Pathway to 2-Amidophenol-Derived Phytotoxic Metabolites." Molecules 27, no. 15 (2022): 4786. http://dx.doi.org/10.3390/molecules27154786.

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Incubation of Aminobacter aminovorans, Paenibacillus polymyxa, and Arthrobacter MPI764 with the microbial 2-benzoxazolinone (BOA)-degradation-product 2-acetamido-phenol, produced from 2-aminophenol, led to the recently identified N-(2-hydroxy-5-nitrophenyl) acetamide, to the hitherto unknown N-(2-hydroxy-5-nitrosophenyl)acetamide, and to N-(2-hydroxy-3-nitrophenyl)acetamide. As an alternative to the formation of phenoxazinone derived from aminophenol, dimers- and trimers-transformation products have been found. Identification of the compounds was carried out by LC/HRMS and MS/MS and, for the n

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2

Nagarsha, K. M., T. M. Sharanakumar, D. Ramesh, et al. "NOVEL SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF N-(5BROMO-2-(5-PHENYL1,3,4-OXADIAZOL-2-YL)NAPHTHA[2,1-B]FURAN-1- YL)ACETAMIDE AND N-(5-NITRO-2-(5-PHENYL-1,3,4- OXADIAZOL-2-YL)NAPHTHA[2,1-BFURAN-1-YL]ACETAMIDE AND THEIR DERIVATIVES." RASAYAN Journal of Chemistry 16, no. 01 (2023): 167–75. http://dx.doi.org/10.31788/rjc.2023.1618088.

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The novel derivatives of naphtho-furan such N-(5bromo-2-(5-phenyl-1,3,4-oxadiazol-2-yl)naphtha[2,1-b]furan-1- yl)acetamide (8), N-(5-bromo-2-(hydrazinecarbonyl)naphtha[2,1-b]furan-1-yl]acetamide (7), ethyl-1-acetamido-5- bromonaphtho[2,1-b]furan-2-carboxylate (6), N-(5-nitro-2-(5-phenyl-1,3,4-oxadiazol-2-yl)naphtha[2,1-bfuran-1- yl]acetamide (5),N-(2-(hydrazinecarbonyl)-5-nitronaphtho[2,1-b]furan-1-yl)acetamide (4), ethyl-1-acetamido-5- nitrpnaphtho[2,1-b]furan-2-carboxylate (3), are prepared by ethyl-1-acetamidonaphtho[2,1-b]furan-2-carboxyate and ethyl 1-aminonaphtho[2,1-b]furan-2-carboxylat

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3

Zhou, Zhong-cheng, and Wan-yin Shu. "Synthesis and characterization of 2-hydroxy-N-methyl-N-phenyl-acetamide." Journal of Central South University of Technology 9, no. 1 (2002): 25–29. http://dx.doi.org/10.1007/s11771-002-0006-2.

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4

Hashem, Aya B., Olfat A. Nief, and Abdulkader M. Noori. "Synthesis, Characterization, and Antimicrobial Evaluation of Thiadiazole Derivatives Derived from 2-Amino-5-Thio-1,3,4-Thiadiazole." Iraqi Journal of Industrial Research 11, no. 2 (2024): 87–96. http://dx.doi.org/10.53523/ijoirvol11i2id402.

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This manuscript introduces a series of novel Schiff base and heterocyc-licring compounds, focusing on derivatives of 1,3-oxazepine and thiazo-lidinone.The derivative (2-Hydroxy-N-(5-mercapto-[1,3,4] thiadiazol-2-yl)-2-phenyl-acetamide was created by reacting ethyl mandelate ester[M1] and 2-amino-5-thio-1,3,4-thiadiazole compound to produce new compound [M2] and after that, compound [M2] was reacted with hydrazine hydrate 99% in dry DMF solvent, yielding the compound (N-(5-Hydrazino-[1,3,4]thiadiazol-2-yl)-2-hydroxy-2-phenyl-acetamide [M3]. In contrast , the Schiff base compound [M4] were synth

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5

Arif, Anum, Saba Majeed, Shabana Usman Simjee, et al. "Evaluation of Anti-inflammatory, Antioxidant and Xanthine Oxidase Inhibitory Potential of N-(2-hydroxy phenyl) Acetamide." Pak-Euro Journal of Medical and Life Sciences 5, no. 2 (2022): 309–18. http://dx.doi.org/10.31580/pjmls.v5i2.2528.

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Nonsteroidal anti-inflammatory drugs has long been used to treat various pathological conditions like arthritis, gout, diabetes, cancer, and cardiovascular diseases. Although exploring the effective anti-inflammatory agents possessing antioxidant along with pain relieving properties is still challenging. Acetamide-containing compounds are known to possess analgesic and anti-inflammatory activity. The purpose of this study is to evaluate the anti-inflammatory, anti-oxidant, xanthine oxidase, and analgesic activity of an acetamide derivative, N-(2-Hydroxyphenyl) Acetamide. In-vitro anti-inflamma

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6

Gowda, Basavalinganadoddy Thimme, Helmut Paulus, and Jozef Kožíšek. "Effect of Substitution on the Molecular Geometry of N-(2/3/4-Substituted-phenyl)-2,2-dichloro-acetamides, 2/3/4-XC6H4NH-CO-CHCl2 (X = CH3 or Cl)." Zeitschrift für Naturforschung A 61, no. 12 (2006): 675–82. http://dx.doi.org/10.1515/zna-2006-1210.

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2MPDCAThe effect of ring substitution on the molecular geometry of amides of the type 2/3/4-XC6H4NHCO- CHCl2 (X = CH3 or Cl) has been studied by determining the crystal structures of the compounds N-(2-methylphenyl)-2,2-dichloro-acetamide, 2-CH3C6H4NH-CO-CHCl2 (); N-(3-methylphenyl)- 2,2-dichloro-acetamide, 3-CH3C6H4NH-CO-CHCl2 (3MPDCA) and N-(3-chlorophenyl)- 2,2-dichloro-acetamide, 3-ClC6H4NH-CO-CHCl2 (3CPDCA). The results are analyzed along with our earlier crystal structures of the amides N-(phenyl)-2,2-dichloro-acetamide, C6H5NH-COCHCl2 (PDCA); N-chloro-N-(phenyl)-2,2-dichloro-acetamide,

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7

Whiteaker, Laura R., Urmila Pal Chaudhuri, Douglas R. Powell, and Robert P. Houser. "2-Phenyl-N-(2-pyridylmethyl)acetamide." Acta Crystallographica Section E Structure Reports Online 62, no. 8 (2006): o3337—o3338. http://dx.doi.org/10.1107/s1600536806026092.

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8

Dr., Haresh R.Patel, and H. D. Chaudhari Dr. "Characterization and bio-chemical synthesis of Gd3+rare metal Complex with benzoxazole derivative." International Journal of Life Sciences Research 10, no. 4 (2022): 27–34. https://doi.org/10.5281/zenodo.7276919.

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<strong>Abstract:</strong> The grouping of some rare metal ions with an significant 2-(1,3-benzoxazole -2-yl - sulfanyl )-N-phenyl acetamide (BSPA) ligand to form coordination compounds is an important area of present research. Less explored biologically important 2-(1,3-benzoxazole -2-yl - sulfanyl )-N-phenyl acetamide  ligand is allowed to react with solution of some rare metal perchlorates and attempt has been made to synthesize solid  2-(1,3-benzoxazole -2-yl- sulfanyl )-N-phenyl acetamide complexes. These 2-(1,3-benzoxazole-2-yl-sulfanyl )-N-phenyl acetamide  complex are su

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9

Dr., H. D. Chaudhari, and Haresh R.Patel Dr. "Chemical kinetic of Dy3+ rare metal Complex with Benzoxazole Derivative." International Journal of Interdisciplinary Research and Innovations 10, no. 4 (2022): 40–45. https://doi.org/10.5281/zenodo.7320022.

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<strong>Abstract:</strong> The combination of some rare metal ions with an important 2-(1,3-benzoxazole -2-yl - sulfanyl )-N-phenyl acetamide (BSPA) ligand to form coordination compounds is an important area of current research. Less explored biologically important 2-(1,3-benzoxazole -2-yl - sulfanyl )-N-phenyl acetamide  ligand is allowed to react with solution of some rare metal perchlorates and attempt has been made to synthesize solid  2-(1,3-benzoxazole -2-yl- sulfanyl )-N-phenyl acetamide complexes. These 2-(1,3-benzoxazole-2-yl-sulfanyl )-N-phenyl acetamide  complexes are

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10

Cheng, Jing, Neng-Xue Wang, and Guang-Fu Yang. "2,2-Dichloro-N-{[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide." Acta Crystallographica Section E Structure Reports Online 61, no. 11 (2005): o3628—o3629. http://dx.doi.org/10.1107/s1600536805031831.

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11

Sawant, Ramesh, and Deepali Kawade. "Synthesis and biological evaluation of some novel 2-phenyl benzimidazole-1-acetamide derivatives as potential anthelmintic agents." Acta Pharmaceutica 61, no. 3 (2011): 353–61. http://dx.doi.org/10.2478/v10007-011-0029-z.

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Synthesis and biological evaluation of some novel 2-phenyl benzimidazole-1-acetamide derivatives as potential anthelmintic agentsThe present study describes synthesis of a series of 2-phenyl benzimidazole-1-acetamide derivatives and their evaluation for anthelmintic activity using Indian adult earthworms,Pheretima posthuma.The structure of the title compounds was elucidated by elemental analysis and spectral data. The compounds 4-({[2-(4-nitrophenyl)-1H-benzimidazol-1-yl]acetyl}amino) benzoic acid (3a),N-ethyl-2-[2-(4-nitrophenyl)-1H-benzimidazol-1-yl] acetamide (3c),N-benzyl-2-[2-(4-nitrophen

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12

Zhang, Guang-You, Di-Juan Chen, Shu-Hong Wang, Ting Yang, and Jian-Guo Chang. "N-[(R)-(2-Chlorophenyl)(cyclopentyl)methyl]-N-[(R)-(2-hydroxy-5-methylphenyl)(phenyl)methyl]acetamide." Acta Crystallographica Section E Structure Reports Online 65, no. 11 (2009): o2948. http://dx.doi.org/10.1107/s1600536809044808.

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13

Siluvairaj, Richard Rajkumar, Vallal Perumal Govindasamy, Rajarajan Govindasamy, Periyanayagasamy Vanathu Chinnappan, and Thanikachalam Venugopal. "Comparative study of 4-((4-aminophenyl)diazenyl)-2-((2-phenylhydrazono)methyl)phenol and N-(4-((4-hydroxy-3-((2-phenylhydrazono)methyl)phenyl)diazenyl)phenyl)acetamide - DFT method." European Journal of Chemistry 15, no. 1 (2024): 50–70. http://dx.doi.org/10.5155/eurjchem.15.1.50-70.2498.

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Theoretical calculation of 4-((4-aminophenyl)diazenyl)-2-((2-phenylhydrazono)methyl) phenol (1) and N-(4-((4-hydroxy-3-((2-phenylhydrazono)methyl)phenyl)diazenyl)phenyl) acetamide (2) was studied by DFT/B3LYP/6-311+G(d,p) basis set. The calculated values of geometric structural parameters, Fourier transform infrared spectral data, highest occupied molecular orbital and lowest unoccupied molecular orbital, natural bond orbital, nucleus-independent chemical shifts, Fukui function, polarizability, hyperpolarizability, and UV data of compounds 1 and 2 clearly indicate that substitution of the amin

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14

Dr., H. D. Chaudhari, and Haresh R. Patel Dr. "Antimicrobial and Chemical kinetic studies of Sm3+ rare metal Complex with Benzoxazol derivative." International Journal of Life Sciences Research 10, no. 4 (2022): 35–40. https://doi.org/10.5281/zenodo.7307555.

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<strong>Abstract:</strong> The mixture of some rare metal ions with an important 2-(1,3-Benzoxazole -2-yl - sulfanyl)-N-phenyl acetamide (BSPA) ligand to form coordination complex is an important area of current research. Less explored biologically important 2-(1,3-benzoxazole -2-yl - sulfanyl )-N-phenyl acetamide  ligand is allowed to react with solution of some rare metal perchlorate and attempt has been made to synthesize solid  2-(1,3-benzoxazole -2-yl- sulfanyl )-N-phenyl acetamide complex. These 2-(1,3-benzoxazole-2-yl-sulfanyl)-N-phenyl acetamide complex are subjected to antim

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15

Moskvina, Viktoria, Olexander Turov, Tetyana Shokol, and Volodymyr Khilya. "Synthesis and NMR spectroscopy investigations of functionalized spiropyranochromenediones and their spirothiadiazole derivatives." Ukrainica Bioorganica Acta 16, no. 2 (2021): 18–22. http://dx.doi.org/10.15407/bioorganica2021.02.018.

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This investigation focuses on the synthesis of spiropyranoneoflavones and the modification of obtained compounds at the exocyclic oxygen atom. Kabbe cyclization of 6-acetyl-7‑hydroxy-8-methyl-4-phenyl-2H-chromene-2-one with cyclohexanone or cyclopentanone in the presence of pyrrolidine provided 10-methyl-4-phenyl-2H-spiro[cyclohexane(cyclopentane)-1’,8-pyrano[3,2-g]chromene]-2,6(7H)-diones. Their new functionalized derivatives with thiosemicarbazide residues were synthesized. Acetylation of obtained thiosemicarbazones with acetic anhydride proceeded via cyclization of thiosemicarbazide fragmen

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16

Fun, Hoong-Kun, Chin Wei Ooi, Dinesha, S. Viveka, and G. K. Nagaraja. "(Z)-N-[2-(N′-Hydroxycarbamimidoyl)phenyl]acetamide." Acta Crystallographica Section E Structure Reports Online 69, no. 3 (2013): o370—o371. http://dx.doi.org/10.1107/s1600536813003371.

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17

Gowda, Basavalinganadoddy Thimme, Jozef Kožíšek, Ingrid Svoboda, and Hartmut Fuess. "Effect of Meta-Substitution on Solid State Geometry of N-(Aryl)-2,2,2-trichloro-acetamides, 3-XC6H4NH-CO-CCl3 and 3,5-X2C6H3NH-CO-CCl3 (X = Cl, CH3)." Zeitschrift für Naturforschung A 62, no. 1-2 (2007): 91–100. http://dx.doi.org/10.1515/zna-2007-1-213.

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The crystal structures of N-(meta-substituted phenyl)-2,2,2-trichloro-acetamides such as N- (3-methylphenyl)-2,2,2-trichloro-acetamide, 3-CH3C6H4NH-CO-CCl3 (3MPTCA); N-(3-chlorophenyl)- 2,2,2-trichloro-acetamide, 3-ClC6H4NH-CO-CCl3 (3CPTCA); N-(3,5-dimethylphenyl)- 2,2,2-trichloro-acetamide, 3,5-(CH3)2C6H3NH-CO-CCl3 (35DMPTCA) and N-(3,5-dichlorophenyl)- 2,2,2-trichloro-acetamide, 3,5-Cl2C6H3NH-CO-CCl3 (35DCPTCA) have been determined at room temperature. The crystal system, space group, formula units and lattice constants (Å ) of the new structures are: 3MPTCA: orthorhombic, Pbca, Z = 8, a = 1

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18

Gowda, Basavalinganadoddy Thimme, Helmut Paulus, Ingrid Svoboda, and Hartmut Fuess. "Structural Studies on N-(Phenyl)-2,2,2-trimethyl-acetamide, N-(2,4,6-Trimethylphenyl)-2,2,2-trimethyl-acetamide and N-(2,4,6-Trimethylphenyl)-2,2,2-trichloro-acetamide, 2,4,6-X3C6H2NH-CO-CY3 (X = H or CH3; Y = CH3 or Cl)." Zeitschrift für Naturforschung A 62, no. 5-6 (2007): 331–37. http://dx.doi.org/10.1515/zna-2007-5-615.

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To study the effect of side chain and ring substitutions on the solid state geometry of amides of the general formulae C6H5NH-CO-CX3 and 2,4,6-X3C6H2NH-CO-CH3−yXy (X = CH3 or Cl and y = 0,1,2, 3), crystal structures of N-(phenyl)-2,2,2-trimethyl-acetamide, C6- H5NH-CO-C(CH3)3 (PTMA); N-(2,4,6-trimethylphenyl)-2,2,2-trimethyl-acetamide, 2,4,6-(CH3)3- C6H2NH-CO-C(CH3)3 (TMPTMA) and N-(2,4,6-trimethylphenyl)-2,2,2-trichloro-acetamide, 2,4, 6-(CH3)3C6H2NH-CO-CCl3 (TMPTCA) have been determined. The data are analyzed along with those of N-(phenyl)-acetamide, C6H5NH-CO-CH3; N-(phenyl)-2,2,2-trichloro

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19

Kunwar, Bimal, Shabana U. Simjee, and Huma Jawad. "Attenuation of Collagen-Induced Arthritis in Rats by N-(2-hydroxy phenyl) Acetamide." Journal of Pharmacological and Toxicological Methods 88 (November 2017): 206–7. http://dx.doi.org/10.1016/j.vascn.2017.09.127.

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20

Shams, Sidrah, Loay Ibrahim Lubbad, Shabana U. Simjee, and Almas Jabeen. "N-(2-hydroxy phenyl) acetamide ameliorate inflammation and doxorubicin-induced nephrotoxicity in rats." International Immunopharmacology 123 (October 2023): 110741. http://dx.doi.org/10.1016/j.intimp.2023.110741.

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21

Bai, Yu-Bin, Xia-Hui Chen, Ya-Tuan Ma, An-Ling Zhang, and Jin-Ming Gao. "2-Chloro-N-methyl-N-[2-(methylamino)phenyl]acetamide." Acta Crystallographica Section E Structure Reports Online 69, no. 2 (2013): o229. http://dx.doi.org/10.1107/s1600536813000494.

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The title compound, C10H13ClN2O, was obtained as a by-product in the reaction of 2-chloromethyl-1H-benzimidazole, dimethyl sulfate and toluene to synthesise 2-chloromethyl-1-methylbenzimidazole. The dihedral angle between the benzene ring and the acetamide group is 89.72 (6)° while that between the aromatic ring and the chloracetyl group is 84.40 (4)°. In the crystal, adjacent molecules are linked by pairs of N—H...O hydrogen bonds into inversion dimers.

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22

Ahmad, Kartini, Noel F. Thomas, Mohd Fadzli Din, Khalijah Awang, and Seik Weng Ng. "N′-{2-[2-(4-Methoxyphenyl)ethenyl]phenyl}acetamide." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (2009): o1289. http://dx.doi.org/10.1107/s1600536809017395.

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In the title compound, C17H17NO2, the phenylene rings are nearly coplanar [dihedral angle 7.3 (1)°]. The acetamido group is twisted out of the plane of the aromatic ring in order to form an N–H...O hydrogen bond to the acetamido group of an adjacent molecule, generating a helical chain running along thebaxis.

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23

Ahmad, Kartini, Noel F. Thomas, Mohd Azlan Nafiah, Khalijah Awang, and Seik Weng Ng. "N′-{2-[2-(3-Methoxyphenyl)ethenyl]phenyl}acetamide." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (2009): o1290. http://dx.doi.org/10.1107/s1600536809017401.

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In the title compound, C17H17NO2, the phenylene rings are bent with respect to the carbon–carbon double bond [dihedral angle between rings = 39.6 (1)°]. The acetamido group is twisted out of the plane of the aromatic ring [dihedral angle = 44.2 (1)°] in order to form an N–H...O hydrogen bond to the acetamido group of an adjacent molecule, generating a zigzag chain running along thecaxis.

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24

Simjee, Shabana, Huma Jawed, Kahkashan Perveeen, and Siddiqua Jamall. "N-(2-hydroxy phenyl) acetamide (NA-2): A novel suppressor adjuvant-induced arthritis in rats." Journal of Pharmacological and Toxicological Methods 75 (September 2015): 171–72. http://dx.doi.org/10.1016/j.vascn.2015.08.048.

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25

Que, Chuqiang, Peipei Huang, Zhanhui Yang, Ning Chen, and Jiaxi Xu. "Intramolecular Carbene C-H Insertion Reactions of 2-Diazo-2-sulfamoylacetamides." Molecules 24, no. 14 (2019): 2628. http://dx.doi.org/10.3390/molecules24142628.

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The intramolecular C-H insertions of carbenes derived from 2-diazo-2-sulfamoylacetamides were studied. 2-Diazo-2-sulfamoylacetamides were first prepared from chloroacetyl chloride and secondary amines through acylation followed by sequential treatments with sodium sulfite, phosphorus oxychloride, secondary amines, and 4-nitrobenzenesulfonyl azide. The results indicate that: (1) 2-diazo-N,N-dimethyl-2-(N,N-diphenylsulfamoyl)acetamide can take the formal aromatic 1,5-C-H insertion in its N-phenylsulfonamide moiety to afford the corresponding 1,3-dihydrobenzo[c]isothiazole-3-carboxamide 2,2-dioxi

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26

Dr., H. D. Chaudhari, and Haresh R.Patel Dr. "Chemical kinetic activity of Iridium rare metal Complex with Banzoxazole Derivative." International Journal of Life Sciences Research 12, no. 4 (2024): 1–4. https://doi.org/10.5281/zenodo.13902116.

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<strong>Abstract:</strong> The combination of Iridium rare metal ions with an important 2-(1,3-benzoxazole -2-yl - sulfanyl )-N-phenyl acetamide (BSPA) ligand to form coordination compounds is an important area of current research. Less explored biologically important 2-(1,3-benzoxazole -2-yl - sulfanyl )-N-phenyl acetamide  ligand is allowed to react with solution of some rare metal perchlorates and attempt has been made to synthesize solid  2-(1,3-benzoxazole -2-yl- sulfanyl )-N-phenyl acetamide complexes. These 2-(1,3-benzoxazole-2-yl-sulfanyl )-N-phenyl acetamide  complexes

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27

Lutsenko, R. V., V. N. Bobyrev, and T. A. Devyatkina. "Anxiolytic effect of 2-oxyindolin-3-glyoxylic acid derivatives: computer prediction and experimental confirmation." Kazan medical journal 94, no. 4 (2013): 553–60. http://dx.doi.org/10.17816/kmj1970.

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Aim. To complete the computer prediction of possible spectrum of biological activity of simple amides of 2-oxyindolin-3-glyoxylic acid derivatives and to test their anxiolytic activity in experiment. Methods. The prediction of possible spectrum of biological activity of simple amides of 2-oxyindolin-3-glyoxylic acid derivatives was performed using PASS (Prediction of Activity Spectra for Substances) software. The experimental part was performed on 140 adult rats of both sexes. Animals were distributed to subgroups (n=10 in each subgroup) according to age and gender. Experimental screening for

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28

Khan, F. Nawaz, S. Mohana Roopan, N. Malathi, Venkatesha R. Hathwar, and Mehmet Akkurt. "N-[4-Chloro-2-(2-chlorobenzoyl)phenyl]acetamide." Acta Crystallographica Section E Structure Reports Online 66, no. 6 (2010): o1434. http://dx.doi.org/10.1107/s1600536810018696.

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29

Vereshchagina, Yana A., Alsu Z. Alimova, Denis V. Chachkov, Rezeda R. Khanafieva, Oleg I. Artyushin, and Eleonora A. Ishmaeva. "Conformational Analysis of 2-Chloro-N-[2-((Diphenylphosphoryl)Methyl)Phenyl]-Acetamide and 2-Chloro-N-[2-((Diphenylthiophosphoryl)Methyl)Phenyl]Acetamide." Phosphorus, Sulfur, and Silicon and the Related Elements 190, no. 5-6 (2015): 803–5. http://dx.doi.org/10.1080/10426507.2014.989433.

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30

Ravi Kumar, Gollapudi, Chandra Mohan Kurmarayuni, Manideepa Indupalli, Ramya Krishna Pallapati, and Hari Babu Bollikolla. "Synthesis of new analogs of 3-methyl-[1,2,4] triazolo [3,4-a] phthalazines via Suzuki coupling and evaluation of their anticancer and antimicrobial activity." Mediterranean Journal of Chemistry 8, no. 4 (2019): 261–69. http://dx.doi.org/10.13171/mjc841905257hbb.

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A series of new N-aryl substituted phenyl acetamide analogs of 3-methyl-[1,2,4] triazolo[3,4-a] phthalazines were synthesized starting from commercially available, in-expensive phthalic anhydride in good yields (65-75 %) via Suzuki Coupling. These compounds were tested for inhibition activity against HCT 116 cancer cell line by using MIT assay. Among the library of compounds, N-(3-methoxyphenyl)-2-(4-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)phenyl) acetamide followed by 2-(4-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)phenyl)-N-(m-tolyl) acetamide and Â N-(3-chlorophenyl)-2-(4-(3-me

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31

Senge, Mathias O. "N-[4-(Di-2-pyrrolylmethyl)phenyl]acetamide." Acta Crystallographica Section E Structure Reports Online 63, no. 9 (2007): o3679. http://dx.doi.org/10.1107/s1600536807037385.

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32

Gurumoorthy, Anuradha, Vasuki Gopalsamy, Ramamurthi K, Poonam Piplani, and Ruchi Malik. "N-[4-(2-Morpholinoethoxy)phenyl]acetamide monohydrate." Acta Crystallographica Section E Structure Reports Online 67, no. 2 (2011): o262. http://dx.doi.org/10.1107/s1600536810053675.

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33

Ahmad, Saba, Muhammad Akhyar Farrukh, Fahim Ashraf Qureshi, Ahmad Adnan, and Mehmet Akkurt. "N-{4-[(2-Methoxyphenyl)sulfamoyl]phenyl}acetamide." Acta Crystallographica Section E Structure Reports Online 67, no. 2 (2011): o303—o304. http://dx.doi.org/10.1107/s1600536811000432.

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34

Journal, Baghdad Science. "Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity." Baghdad Science Journal 10, no. 3 (2013): 818–27. http://dx.doi.org/10.21123/bsj.10.3.818-827.

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A series of new compounds including p-bromo methyl pheno acetate [2]. N-( aminocarbonyl)–p-bromo pheno acetamide [3] , N-( aminothioyl) -p-bromo phenoacetyl amide [4], N-[4-(p-di phenyl)-1,3-oxazol-2-yl]-p-bromopheno acetamide [5],N-[4-p-di phenyl]-1,3-thiazol-2-yl-p-bromo phenoacet amide [6], p-bromopheno acetic acid hydrazide [7] , 1-N-(p-bromo pheno acetyl)-1,2-dihydro-pyridazin-3,6- dione [8], 1-N-(p-bromo pheno acetyl)-1,2-dihydro-phthalazin-3,8- dione[ 9], 1-(p-bromo pheno acetyl)-3-methylpyrazol-5-one [10] and 1-(p-bromo phenol acetyl)- 3,5-dimethyl pyrazole [11] have been synthesized.

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35

Jassim, Wissam K., A. M. Kadir, and Ibtisam K. Jassim. "Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity." Baghdad Science Journal 10, no. 3 (2013): 818–27. http://dx.doi.org/10.21123/bsj.2013.10.3.818-827.

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A series of new compounds including p-bromo methyl pheno acetate [2]. N-( aminocarbonyl)–p-bromo pheno acetamide [3] , N-( aminothioyl) -p-bromo phenoacetyl amide [4], N-[4-(p-di phenyl)-1,3-oxazol-2-yl]-p-bromopheno acetamide [5],N-[4-p-di phenyl]-1,3-thiazol-2-yl-p-bromo phenoacet amide [6], p-bromopheno acetic acid hydrazide [7] , 1-N-(p-bromo pheno acetyl)-1,2-dihydro-pyridazin-3,6- dione [8], 1-N-(p-bromo pheno acetyl)-1,2-dihydro-phthalazin-3,8- dione[ 9], 1-(p-bromo pheno acetyl)-3-methylpyrazol-5-one [10] and 1-(p-bromo phenol acetyl)- 3,5-dimethyl pyrazole [11] have been synthesized.

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36

Griffin, James L., and Thomas R. Harger. "Red Rice (Oryza sativa) and Junglerice (Echinochloa colonum) Control in Solid-Seeded Soybeans (Glycine max)." Weed Science 34, no. 4 (1986): 582–86. http://dx.doi.org/10.1017/s0043174500067473.

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Red rice (Oryza sativaL. # ORYSA) control in soybeans [Glycine max(L.) Merr.] was 93% or more with shallow-incorporated alachlor [2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide] at 3.9 kg ai/ha, metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide] at 2.8 kg ai/ha, and trifluralin [2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)benzenamine] at 1.7 kg ai/ha. Junglerice [Echinochloa colonum(L.) Link. # ECHCO] control was 80% with alachlor but 90% or more with metolachlor and trifluralin when applied at the same rates. Sethoxydim {2-[1-(ethoxyimino)butyl]-

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37

Khader, Syed Zameer Ahmed, Sidhra Syed Zameer Ahmed, Priya Dharshini Saravanan, et al. "Computational Approach to Target SARS-CoV-2 Proteins Using Bioactives Derived from Nerium indicum." BIO Web of Conferences 172 (2025): 02011. https://doi.org/10.1051/bioconf/202517202011.

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SARS-CoV-2 spreads through inhalation or contact with infected individuals, with its receptor-binding domain (RBD) facilitating cell entry and causing severe effects. In order to identify a better ailment for this disease, the current study has been made using In-silico tools to predict the interaction of SARS-CoV-2 with natural ligand C-1: N-(4-Hydroxyphenyl)-2-methoxy-2-phenyl-acetamide and C-2: N-(4-Hydroxy-phenyl)-2-phenyl-N-phenylacetyl-acetamide of Nerium indicum as it is concerned with the antiviral property. The target proteins such as Glycoprotein (2GHV), Spike S3 (6LVN) and Protease

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38

Astakhova, V. V., and M. Yu Moskalik. "NBS-induced triflamidation of 2-methyl-1-pentene." Журнал органической химии 59, no. 8 (2023): 1100–1104. http://dx.doi.org/10.31857/s051474922308013x.

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Reaction of trifluoromethanesulfonamide with 2-methyl-1-pentene in the presence of N -bromosuccinimide in acetonitrile leads to N -{2-methyl-1-[(trifluoromethyl)sulfonamido]pentan-2-yl}acetamide. Cyclization of N -[1-phenyl-2-(triflamido)ethyl]acetamide with excess K2CO3 gives the corresponding 4,5-dihydro-1 H imidazole.

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39

Olszewska, E., S. Pikus, and B. Tarasiuk. "New powder diffraction data of some derivatives of N-alkyl (aryl)-2,4-dichlorophenoxyacetamide—New potential pesticides." Powder Diffraction 23, no. 4 (2008): 338–49. http://dx.doi.org/10.1154/1.3009636.

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Four new derivatives of N-aryl-2,4-dichlorophenoxyacetamide, 2-(2,4-dichlorophenoxy)-N-(4-fluorophenyl)acetamide, N-(4-bromophenyl)-2-(2,4-dichlorophenoxy)acetamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-(2,4-dichlorophenoxy)acetamide, and N-(3-chloro-4-fluorophenyl)-2-(2,4-dichlorophenoxy)acetamide, and two of N-alkyl-2,4-dichlorophenoxyacetamide, N-dodecyl-2,4-dichlorophenoxy-acetamide and 2-(2,4-dichlorophenoxy)-N-hexadecylacetamide, have been characterized by X-ray powder diffraction. These organic compounds are potential pesticides. Experimental 2θ peaks positions, relative peak intens

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40

Parmar, M. B., J. H. Pandya, and M. K. Vara. "Synthesis, Characterization of Various Substituted (E)-2-(2-butyl-5-chloro-4-((phenylimino)methyl)-1H-imidazol-1-yl)-N-(4-(3-oxomorpholino) phenyl)acetamide." Journal of Scientific Research 15, no. 2 (2023): 509–18. http://dx.doi.org/10.3329/jsr.v15i2.61736.

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A highly efficient, convergent approach to the synthesis of various substituted (E)-2-(2-butyl-5-chloro-4-((phenylimino)methyl)-1H-imidazol-1-yl)-N-(4-(3-oxomorpholino)phenyl) acetamide analogues is described. Directed vilsmeyer formylation of methyl pentanimidate with glycine provides the key intermediate 2-butyl-5-chloro-1H-imidazole-4- carbaldehyde (INT-01). BCFI (INT-01) is a major active metabolite and the most significant intermediate of Losartan. Therefore, BCFI moiety has scope for good application in medicine. Morpholin-3-one derivative reacts with chloroacetyl chloride in presence of

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41

K. Jassim, Ibtisam, Sawsan S. Harth, Rua M. Dhedan, and Ali Obais Abd. "Synthesis and study the biological activity of some six, five and fused ring heteroatome systems derived from 2-mercapto benzothiazole." Tikrit Journal of Pharmaceutical Sciences 8, no. 1 (2023): 96–105. http://dx.doi.org/10.25130/tjphs.2012.8.1.12.96.105.

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In this paper ,new series of 2-hydrazino benzothiazole [1], 2-N-benzothiazole-N`-phenyl hydrazine carboxamide [2], 2-N-[(3)-N`-phenyl-5-(p-bromophenyl)-2`-hydroxy-1,3-oxazolin-2`-yl] benzothiazol hydrazine [3] , 2-N-benzothiazole-N`-1-naphthyl hydrazine carboxamide [4], 2-N-[(3`)-N`-(1-naphthyl)-5`-(p-bromo phenyl)-2`-hydroxy-1,3-oxazolin-2`-yl)] benzothiazol hydrazine [5], of 2-thiaacetic acid benzothiazole [6] ,2-thiaacetyl chloride benzothiazole [7], 5-amino-2-mercapto-1,3,4-thiadiazole [8], of 2-mercapto-[5-acetamid thiamethyl benzothiazol]-1,3,4-thiadiazole [9], 2-phenyl-5-chloromethyl-1,

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42

Li, Xue-Mei, Yong-Hong Wen, Mao-Jie Li, and Shu-Sheng Zhang. "N-Phenyl-2-(quinolin-8-yloxy)acetamide hemihydrate." Acta Crystallographica Section E Structure Reports Online 61, no. 8 (2005): o2389—o2390. http://dx.doi.org/10.1107/s1600536805020751.

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43

Yusof, Mohd Sukeri Mohd, Nur Rafikah Razali, Suhana Arshad, Azhar Abdul Rahman, and Ibrahim Abdul Razak. "2,2-Diphenyl-N-{[2-(trifluoromethyl)phenyl]carbamothioyl}acetamide." Acta Crystallographica Section E Structure Reports Online 69, no. 8 (2013): o1255—o1256. http://dx.doi.org/10.1107/s1600536813018680.

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44

Belay, Yonas H., Henok H. Kinfe, and Alfred Muller. "N-[4-(2-Propyn-1-yloxy)phenyl]acetamide." Acta Crystallographica Section E Structure Reports Online 68, no. 11 (2012): o3072. http://dx.doi.org/10.1107/s1600536812041207.

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45

Mosslemin, Mohammad Hossein, Samira Arab-Salmanabadi, and Mozhgan Masoudi. "N-[(2-Hydroxynaphthalen-1-yl)(phenyl)methyl]acetamide." Acta Crystallographica Section E Structure Reports Online 63, no. 2 (2007): o444—o445. http://dx.doi.org/10.1107/s1600536806053840.

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46

MUNEEZA, LODHI, MAJEED SABA, IMAD REHAN, and USMAN SIMJEE SHABANA. "ANTI-NEUROINFLAMMATORY AND NEUROPROTECTIVE EFFICACY OF N-(2-HYDROXY PHENYL) ACETAMIDE IN RESPONSE TO LPS-STIMULATED PRIMARY CELL CULTURE." Tianjin Daxue Xuebao (Ziran Kexue yu Gongcheng Jishu Ban)/ 56, no. 08 (2023): 198–208. https://doi.org/10.5281/zenodo.8288538.

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<strong>Abstract</strong> The irreversible and continuing loss of neurons is the fundamental cause of neurodegenerative diseases (ND). The most common age-associated neurodegenerative condition is Alzheimer's disease (AD), and its etiology appears to have a chronic inflammatory component. The stimulation, proliferation, phenotypic and functional modifications in glia can be brought on by a variety of stresses in the central nervous system (CNS), and these modifications are modulated by anti-neuroinflammatory substances. This study evaluated the anti-neuroinflammatory and pro-neurogenic eff

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47

Wannalerse, Boontana, Paradee Kwanmuang, Piangkwan Jansukra, et al. "The Synthesis, Crystal Structure, DFT Calculations and Optical Properties of Orcinolic Derivatives as OH− Indicators." Crystals 12, no. 9 (2022): 1252. http://dx.doi.org/10.3390/cryst12091252.

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The structures of 2-(3-hydroxy-5-methylphenoxy)-N-(4-nitrophenyl)acetamide), B1, and 2-(3-hydroxy-5-methylphenoxy)-N-(4-(trifluoromethyl)phenyl)acetamide, B2, are crystallized in the crystal symmetry of the monoclinic structure and in the space group of P21/c. For the different structures of B1 and B2, B1 displays an absolute planarity conformation with torsion angles of 172.2–179.1. The two molecules of B1 are linked by a hydrogen bond of N–H…O–N–O, where a hydrogen atom of amide is bound to an oxygen atom of the nitro-substituted group. In the case of B2, the molecules are connected to each

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48

Dutkiewicz, Grzegorz, B. P. Siddaraju, H. S. Yathirajan, B. Narayana, and Maciej Kubicki. "2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide." Acta Crystallographica Section E Structure Reports Online 66, no. 2 (2010): o499. http://dx.doi.org/10.1107/s1600536810003375.

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49

Olszewska, E., B. Tarasiuk, and S. Pikus. "New powder diffraction data of some N-derivatives of 4-chloro-3,5-dimethylphenoxyacetamide-potential pesticides." Powder Diffraction 26, no. 4 (2011): 337–45. http://dx.doi.org/10.1154/1.3652921.

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N-derivatives of 4-chloro-3,5-dimethylphenoxyacetamide—2-(4-chloro-3,5-dimethylphenoxy)-N-(4-fluorophenyl)acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-(3-chloro-4-fluorophenyl) acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-[4-chloro-3-(trifluoromethyl)phenyl] acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-[3-chloro-4-methylphenyl]acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-(2,4,6-tribromophenyl) acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-pyridin-2-ylacetamide, 1-[(4-chloro-3,5-dimethylphenoxy)acetyl]-4-methylpiperazine, and 1-benzyl-4-[(4-chloro-3,5-dimethylphenoxy)acetyl]piperazine—have

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50

Nguyen, Cong Tien, Ha Manh Bui, and Duyen Hoang My Nguyen. "Synthesis of 2-(2-(4-Phenyl-2,3-Dihydrobenzo[B][1,4]Thiazepin-2-YL) Phenoxy)-N-(P-Tolyl)Acetamide." Acta Chemica Iasi 26, no. 1 (2018): 13–20. http://dx.doi.org/10.2478/achi-2018-0002.

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Abstract The A new benzothiazepine’s derivative names N-(p-tolyl)-2-(2-(4-phenyl-2,3-dihydrobenzo[b][1,4]thiazepin-2-yl)phenoxy)acetamide was synthesized by reaction of o-aminothiophenol and N-(p-tolyl)-2-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenoxy)acetamide, which was prepared from salicylaldehyde and acetophenone through (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one. The structures of the compounds were determined by IR, 1H-NMR, 13C-NMR and HR-MS spectral data.

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