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Dissertations / Theses on the topic 'N-acyl'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Al-Faiyz, Yasair S. S. "The chemistry of O-acyl derivatives of N-acyl hydroxamic acid." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252534.

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2

Penman, June. "GPR55 and N-acyl amino acids." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/2e07c280-3a61-4f49-a9da-1fa4ffc79fa5.

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G-protein coupled receptor 55 (GPR55) is a novel lipid sensing receptor activated by the endogenous lipid, lysophosphatidylinositol (LPI) and is reported as a putative cannabinoid receptor. However GPR55 shares limited homology with the two cloned cannabinoid receptors (CB<sub>1</sub> and CB<sub>2</sub>) but does exhibit some cannabinoid sensitivity. Recently a family of bioactive lipids, the N-acyl amino acids, are gaining interest due to their structural similarity to endocannabinoids (naturally occurring CB<sub>1</sub> and CB<sub>2</sub> agonists). N-acyl amino acids have little or no affin

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3

Wang, Xueqing. "Oxidative cyclization of phenolic N-acyl sulfonamides." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61303.

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The oxidative activation of appropriately substituted phenols with a hypervalent iodine reagent, in the presence of suitable nitrogen nucleophiles, results in formation of 2- or 4-amidodienones. The process is described as the oxidative amidation of phenols. The dienones thus produced are useful building blocks for the synthesis of alkaloids. The nitrogen nucleophile may be an oxazoline, a sulfonamide or phosphoramide (intramolecular reactions), or a nitrile (bimolecular reaction), but not a carboxamide. This is because carboxamides express Onucleophilicity toward oxidatively activated phenols

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4

Wilkinson, Adam. "N-acyl-homoserine lactone signalling in Rhizobium leguminosarum." Thesis, University of East Anglia, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267721.

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5

Simpson, Mark Geoffrey. "Steroid and heterocycle-based macrocyclic N-Acyl hydrazones." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621549.

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6

Jones, Faye-Ellen. "Inhibition of N-acyl-homoserine lactone quorum sensing." Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602017.

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Quorum-sensing amongst Gram-negative bacteria is an important method of intercellular communication required for conveying information about population density. The extracellular accumulation of the signal molecule involved, N-acyl homoserine lactone (AHL), leading to increases in internal physiological concentration, allows phenotypic switching to occur that is beneficial to the bacterial population. In our laboratory, analysis of the effect of AHL on phenotype currently involves creating null mutants unable to produce AHL, then reintroducing the signal molecule exogenously. With the increasi

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7

Azzaro, Stéphane. "Réactivités radicalaire et organométallique des N-acyl-sulfonimidamides." Paris 6, 2009. http://www.theses.fr/2009PA066331.

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8

Waluk, Dominik Paweł. "Biosynthesis and physiological functions of N-acyl amino acids." Doctoral thesis, Stockholms universitet, Institutionen för genetik, mikrobiologi och toxikologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-75766.

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N-acyl amino acids are lipid signalling molecules that have recently been identified in biological systems. These lipids are structurally related to the endocannabinoids, although they do not activate cannabinoid receptors. In 2001, N-arachidonoyl glycine was the first signalling lipid in this group to be identified in bovine and rat brain and since then, about 50 novel N-acyl amino acids have been identified in mammalian systems. These N-acyl amino acids are involved in regulating pain processes, are anti-inflammatory and regulate body temperature, but the metabolic pathways for production an

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9

Wells, Greggory M. "Synthesis and Biological Activity of N-Acyl Aziridines." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1450458169.

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10

Markey, Michael D. "Synthesis of cribrostatin 6, santiagonamine, and a N-acyl pyridinium salt." Thesis, Boston College, 2008. http://hdl.handle.net/2345/1358.

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11

Tobin, Matthew B. "Genetic engineering of the acyl-coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239249.

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12

Hart, Darren. "Molecular characterisation of the acyl-coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320272.

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13

Patel, Divya. "The synthesis and rearrangement of N-alkyl-O-acyl hydroxamic acid derivatives." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400109.

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14

Gaballa, Mahmoud F. "Chromobacterium Violaceum Strains Growth Conditions Impacting N- Acyl Homoserine Lactones AHL Production." Thesis, Tennessee State University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10268834.

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<p> <i>Chromobacterium violaceum</i> is a Gram-negative bacillus that is a facultative anaerobic, oxidase positive, glucose fermenting, and non-lactose fermenting. <i>C. violaceum</i> is free living which can be found in the soil and water. <i>C. violaceum</i> produces a possible antioxidant called violacein a purple pigment that is considered to be one of the significant characteristics of <i>C.violaceum. Chromobacterium violaceum</i> one of the Gram negative bacteria which use Quorum Sensing (QS) occurs within a single bacterial species, and regulates a lot of different processes ,essentiall

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15

Miller, Jörn Derrick Schuster. "Synthesis of N-alkyl-and N,N-dialkyl-N'-acyl- and N'-aroythioureas, and aspects of their co-ordination chemistry with Pt(II)and Pd(II)." Doctoral thesis, University of Cape Town, 2000. http://hdl.handle.net/11427/6336.

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Includes bibliographical references.<br>The synthesis of simple, and also bipodal N-substituted N'-acyl- and N'-aroylthiourea ligands has been investigated, along with aspects of their co-ordination chemistry to Pt(II) and Pd(II). The ligands are commonly produced by reacting a secondary or primary amine with an acyl or aroyl isothiocyanate. This synthesis requires nucleophilic addition of the amine to the thiocarbonyl carbon of the acyl or aroyl isothocyanate. However, a competitive side-reaction frequently occurs because the amine nucleophile can attack the carbonyl carbon of the isothiocyan

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16

Bhattacharya, Biplob. "Synthesis and Anti-MRSA Activity of Hydrophilic C3-Acylated N-Thiolated β-Lactams and N-Acyl Ciprofloxacin-N-Thiolated β-Lactam Hybrids". Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4289.

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The Turos laboratory has been working with N-thiolated β-lactams for years trying to understand the mode of action and structural features it needs to have biological activity. Over the years new data has shown promising inhibitory activity against various microbes. In this dissertation, a review of the vast amount of work carried out on N-thiolated β-lactams in Turos laboratory has been done and their novelty, in terms of structure and mechanism has been discussed. A complete outline of our work in the discovery and ongoing development of these compounds, starting from our initial, unexpected

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17

Klopper, Reynhardt. "An investigation into the complex formation and potential solvent extraction of Os(IV/III) with N, N - dialkyl - N′- acyl(aroyl)thioureas." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/2762.

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Thesis (MSc (Chemistry and Polymer Science))--University of Stellenbosch, 2006.<br>This study involved the preliminary investigation into the potential liquid-liquid extraction of Os(IV/III) from hydrochloric acid solutions with ligands of type N,N-dialkyl-N′-acyl(aroyl)thioureas (HL), and ultimate selective pre-concentration and separation of Os(IV/III) from the other platinum group metals. Investigations have also been focused towards understanding the speciation of Os(IV) in hydrochloric acid medium. A series of osmium complexes with ligands of type HL have been synthesised and characteris

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18

Geisenberger, Otto. "Nachweis, Verbreitung und Bedeutung von N-Acyl-L-homoserinlactonen bei Gram-negativen Bakterien." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962024791.

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19

Gantner, Stephan Are. "Mikrobielle Ökologie N-Acyl-L-Homoserinlacton-produzierender Bakterien in der Rhizosphäre von Tomatenpflanzen." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-12550.

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20

Gibson, Samantha M. "N → S acyl transfer in peptides and regioselective dihalohydration reactions of propargylic alcohols." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10025951/.

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This thesis describes results obtained during the investigation of peptide thioester formation and regioselective dihalohydration reactions of propargylic alcohols. Chapter 1 explores the formation of peptide thioesters via N  S acyl transfer. Firstly, native chemical ligation (NCL) will be introduced as a powerful tool to join a peptide thioester and a peptide fragment containing an N terminal cysteine. The challenges of making a peptide thioester will be discussed. Following this, the synthesis of model peptides will be reported, including the first synthesis of boronocysteine. The model pe

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21

Ateş, Ebru [Verfasser], and Peter [Akademischer Betreuer] Schreier. "Analytische und Effektor-Studien von N-Acyl-Ethanolaminphosphaten / Ebru Ates. Betreuer: Peter Schreier." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1045153214/34.

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Ateş, Ebru Verfasser], and Peter [Akademischer Betreuer] [Schreier. "Analytische und Effektor-Studien von N-Acyl-Ethanolaminphosphaten / Ebru Ates. Betreuer: Peter Schreier." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-54369.

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23

Doherty, Claire. "The use of directed evolution towards altering the substrate specificity of acyl-coenzyme A : isopenicillin N acyl transferase and transforming it from generalist to specialist." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-use-of-directed-evolution-towards-altering-the-substrate-specificity-of-acylcoenzyme-a-isopenicillin-n-acyl-transferase-and-transforming-it-from-generalist-to-specialist(48bdd12d-f8dd-4bb1-b31b-dae1139cea97).html.

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Acyl Coenzyme A: Isopenicillin N Acyl Transferase (AT) is a key enzyme in the biosynthesis of β-lactam antibiotics in penicillin producing organisms such as P. chrysogenum and A. nidulans. Its natural activity is to exchange the side chain of the low activity antibiotic IPN [18] for the phenylacetyl side chain resulting in the more active antibiotic Penicillin G [5]. The biosynthesis of β-lactams has been exploited towards producing these compounds for therapeutic use. However, increasing bacterial resistance means new analogues in this compound class are constantly sought.As well as improving

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24

Gotschlich, Astrid Susanne. "Nachweis, Verbreitung und Bedeutung von N-Acyl-L-homoserinlactonen bei Vertretern des Burkholderia-cepacia-Komplexes." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963026259.

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25

Schuhegger, Regina Margareta. "Induktion systemischer Resistenz durch N-Acyl-L-homoserinlacton-produzierende Bakterien in der Rhizosphäre von Tomatenpflanzen." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967545919.

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26

Saleeb, Michael A. "Design and Synthesis of N-Acyl Modified Trivalent Sialic Acid Inhibitors of Adenovirus type 37." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96997.

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27

Kang, J. "Native chemical thioesterification : synthesis of peptide and protein thioesters through an N→S acyl shift." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1150770/.

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The total chemical synthesis of a protein provides atomic-level control over its covalent structure, however polypeptides prepared by solid phase peptide synthesis are limited to approximately fifty amino acid residues. This limitation has been overcome by 'Native Chemical Ligation‘, which involves amide bond formation between two unprotected polypeptides: a peptide with a C-terminal thioester and an N-terminal cysteinyl peptide. Synthesis of the required peptide thioester is difficult, particularly by Fmoc-chemistry. During our studies towards the semisynthesis of erythropoietin, we discovere

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28

Heidler, Philipp. "N-Acyl-N-alkylsulfonamide und aktivierte Carbonsäuren als polymergestützte Reagenzien in der konvergenten Parallelsynthese Anwendung und Weiterentwicklung zur Darstellung leitstrukturbasierter Amidbibliotheken /." [S.l.] : [s.n.], 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0722/.

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29

Zhang, Hua. "Histopathology study of cannabinoid receptors and n-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D expression in multiple sclerosis." Thesis, Exeter and Plymouth Peninsula Medical School, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544010.

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30

Cormier, Ryan. "N-Acyl Ciprofloxacins: Synthesis, Antibacterial Activity and Effects on Molecular Loading of Poly(vinyl benzoate) Nanoparticles." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4018.

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Bacterial infections are becoming progressively more difficult to treat due to antibiotic resistance and the decreasing rate at which new antibiotics are brought to market. The Turos laboratory has attempted to tackle this problem for the last 15 years with the discovery of N-thiolated β-lactams leading to the design of polyacrylate nanoparticles to deliver these and other drugs. Chapter 1 discusses many reported instances of utilizing different types of polymeric nanoparticles to deliver antibiotics. Poly(lactic-co-glycolic acid) (PLGA), poly(alkyl cyanoacrylate) (PACA), poly(styrene-co-butyl

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31

Landman, Cécilia. "Implications des N-acyl homosérine lactones, molécules du quorum sensing dans les maladies inflammatoires chroniques intestinales." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066489/document.

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Les N-acyl homosérine lactones sont des molécules du quorum sensing impliquées dans la communication interbactérienne mais elles sont également capables d'intéragir avec les cellules eucaryotes. Rechercher ces molécules dans le contexte des maladies inflammatoires chroniques intestinlaes (MICI) et plus particulièrement dans le cadre de l'étude des conséquences de la dysbiose sur les voies de l'inflammation intestinale est séduisant. En utilisant la spectrométrie de mase, nous avons mis en évidence pour la première fois des AHLs dans l'écosystème intestinal humain, et plus particulièrement une

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Mtongana, Sibusiso. "A multinuclear (1H, 13C, 31P and 195Pt) magnetic resonance spectroscopy study of mixed ligand platinum(II) complexes with new N,N-dialkyl-N'-acyl(aroyl)thioureas as ligands." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52649.

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33

Thomanek, Heike [Verfasser], and Wolfgang [Akademischer Betreuer] Maison. "Modified N-Acyl Homoserine Lactones for the Evaluation of Plant-Bacteria Interactions / Heike Thomanek. Betreuer: Wolfgang Maison." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1066898677/34.

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Thomanek, Heike Verfasser], and Wolfgang [Akademischer Betreuer] [Maison. "Modified N-Acyl Homoserine Lactones for the Evaluation of Plant-Bacteria Interactions / Heike Thomanek. Betreuer: Wolfgang Maison." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://nbn-resolving.de/urn:nbn:de:gbv:18-71670.

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35

Maru, Isafumi. "STUDIES ON STRUCTURE, FUNCTIONS, AND INDUSTRIAL UTILIZATION OF N-ACYL-D-GLUCOSAMINE 2-EPIMERASE FROM PORCINE KIDNEY." Kyoto University, 2001. http://hdl.handle.net/2433/150795.

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36

Kalistratova, Aleksandra. "Tuning bioactive peptides properties : new developments in the O-N acyl transfer reaction and dimerization of unprotected peptides." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT229/document.

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L’intérêt des peptides comme des médicaments potentiels est en constante augmentation. Des stratégies ont été développées pour améliorer la sélectivité, l’activité, et la stabilité des peptides vis-à-vis de la protéolyse. Dans ce mémoire de thèse, deux nouvelles modifications de peptides sont proposées.Dans le premier chapitre, nous présentons une nouvelle application de la réaction de transfert O-N acylique pour la synthèse de peptides agrafés (ou ‘stapled peptides’). L’introduction d’une ‘agrafe’ dans un peptide est un moyen de stabiliser une structure secondaire hélicoïdale en établissant u

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37

Romo, Fernández Juan Manuel. "Stereoselective reactions of N-acyl thiazolidinethiones with trimethyl orthoformate, acetals and diarylmethyl ethers catalyzed by nickel(II) complexes." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/301278.

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In this Doctoral Thesis a new stereoselective Ni(II)–mediated catalytic system for the SN1–like addition of chiral Nacyl thiazolidinethiones to electrophiles able to deliver cationic species under acidic conditions has been developed. Importantly, the nickel(II) complexes used along our studies are structurally simple, commercially available and easy to handle. These complexes coordinate to thioimides to generate an intermediate that, after deprotonation, afford a putative nickel(II) enolate, which is the real nucleophile. In Chapter 1, a totally stereoselective addition of Nacyl thiazol

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38

Peyrottes, Agathe. "Modulation of Inflammation in Intestinal Epithelial and Immune Cells by N-Acyl Homoserine Lactones and their Synthetic Analogues." Thesis, Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS315.pdf.

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Les MICI sont caractérisées par l’inflammation chronique de l’épithélium intestinal et mettent en jeu des facteurs multiples : environnement, prédisposition génétique, perturbations immunitaires et déséquilibre du microbiote appelé dysbiose. Leur prévalence a fortement augmenté au cours des dernières décennies. L’importance de la relation hôte-microbiote implique le mode de communication bactérienne appelé Quorum Sensing. Basé sur les N-Acyl Homoserine Lactones (AHL) chez les bactéries Gram négatif, celui-ci n’avait jamais été étudié dans le microbiote intestinal humain. Notre équipe a identif

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Uroz, Stéphane. "Dégradation des N-acyl homosérine lactones, médiateurs de la régulation quorum sensing : les organismes, les mécanismes, les applications potentielles." Paris 11, 2004. http://www.theses.fr/2004PA112123.

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Les souches bactériennes d'une rhizosphere de tabac appartenant aux genres Comamonas, Pseudomonas, Rhodococcus et Variovorax présentent des cinétiques et des spectres de dégradation de N-AHSL variables. Parmi celles-ci, les souches de Comamonas sp. (D1) et de Rhodococcus (W2) sont capables d'inactiver toutes les N-AHSL quelques soient leurs substitutions sur le carbone 3. Ces deux souches sont capables d'interférer efficacement avec des fonctions régulées par QS chez d'autres bactéries. La dégradation des N-AHSL par la souche W2 est due à au moins deux activités enzymatiques : une activité oxy

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Li, Huanyu. "Structural studies of the BAM complex, OmpU outer membrane protein and lipoprotein N-acyl transferase in Gram-negative bacteria." Thesis, University of East Anglia, 2017. https://ueaeprints.uea.ac.uk/68718/.

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Structural studies of membrane proteins represent a significant challenge in the field owing to their hydrophobic nature, unstable property and resistance to be crystallized. In Gramnegative bacteria, membrane proteins contribute to the characteristic membranous architecture composed of an asymmetric layer of outer membrane (OM) and a symmetric inner cytoplasmic membrane (IM). Outer membrane proteins (OMPs) play essential roles in nutrient uptake, protein transport, outer membrane assembly, and pathogenesis of Gram-negative bacteria. In Escherichia coli, nearly all the outer membrane proteins

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41

Wardenga, Rainer [Verfasser], and Uwe [Akademischer Betreuer] Bornscheuer. "Rekombinante Expression und Design der Aminoacylase 1 für die Synthese von N-Acyl-Aminosäuren / Rainer Wardenga ; Betreuer: Uwe Bornscheuer." Greifswald : Universität Greifswald, 2009. http://d-nb.info/1236692454/34.

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Khalilzadeh, Pouneh. "Formation de Biofilm à Pseudomonas aeruginosa : évaluation d'inhibiteurs potentiels du quorum sensing." Toulouse 3, 2009. http://thesesups.ups-tlse.fr/636/.

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La découverte du Quorum-Sensing (QS), système de communication inter-bactéries, régulant l'expression de nombreux gènes de virulence a offert l'opportunité de contrôler l'infection bactérienne. Pseudomonas aeruginosa est une bactérie opportuniste fréquemment impliquée dans la formation de biofilms résistants aux antibactériens. Des dérivés de la furanone ont été décrits comme de puissants inhibiteurs de formation de biofilm du fait de leur similitude avec les auto-inducteurs naturels du QS, les N-Acyl HomoSérineLactones. Notre objectif a été de concevoir des analogues de la C4-HSL et d'étudier

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43

Hernández, Reyes Casandra [Verfasser]. "Study of N-acyl-homoserine lactones for plant protection against plant and human pathogens and their counteraction / Casandra Hernández Reyes." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1108053343/34.

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44

Jakubczyk, Dorota [Verfasser], and S. [Akademischer Betreuer] Bräse. "Synthesis of isotope labelled and photoactivatable N-acyl-L-homoserine lactones - inter kingdom signalling molecules / Dorota Jakubczyk. Betreuer: S. Bräse." Karlsruhe : KIT-Bibliothek, 2013. http://d-nb.info/1041665539/34.

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Caneschi, Wiliam. "Síntese e avaliação biológica de 1,3,4-oxadiazóis derivados da isoniazida." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/4646.

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Submitted by isabela.moljf@hotmail.com (isabela.moljf@hotmail.com) on 2017-05-25T12:04:02Z No. of bitstreams: 1 williamcaneschi.pdf: 11580354 bytes, checksum: d5186d98d0e023e595e7509f1a08efff (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-05-25T13:32:21Z (GMT) No. of bitstreams: 1 williamcaneschi.pdf: 11580354 bytes, checksum: d5186d98d0e023e595e7509f1a08efff (MD5)<br>Made available in DSpace on 2017-05-25T13:32:21Z (GMT). No. of bitstreams: 1 williamcaneschi.pdf: 11580354 bytes, checksum: d5186d98d0e023e595e7509f1a08efff (MD5) Previo

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Springett, Bradley R. "Design, Synthesis and Biological Evaluation of Inhibitors of Polysialyltransferases PST and STX. Design, synthesis and biological evaluation of a range of N-modified mannosamines, sialic acids and analogues from in silico screening as inhibitors of PolySia-NCAM biosynthesis with anti-migration activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/13528.

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47

Fish, Leigh. "A study of the role of N-acyl homoserine lactones in regulating secondary metabolism and virulence gene expression in Aeromonas species." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266930.

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48

Wathen, Steven Patrick. "The effect of metal ions on the hydrolysis of acyl hydroxylamines and the effect of Cu(II) on the hydrolysis of N-benzoyl iminodiacetic acid and N-benzoyl sarcosine /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487777170406684.

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Gozoua, Emmanuel. "Etude du quorum sensing des bactéries organisées en biofilm en vue de la mise en place des biocides non toxiques." Electronic Thesis or Diss., Toulon, 2019. http://www.theses.fr/2019TOUL0008.

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Abstract:

Le biofouling est un phénomène invasif qui engendre des problèmes économiques et écologiques importants. Dans ce mode de vie privilégié, les micro-organismes communiquent grâce à un système de communication intra- et inter-espèces, voire inter-genre, appelé quorum sensing (QS). Le QS est basé sur les petites molécules diffusibles telles que les N-acyl homosérine lactones (AHL), et est donc impliqué dans de nombreux processus physiologiques, notamment la production de facteurs de virulence, l'émission de bioluminescence et la production de pigments. Dans une étude antérieure, le QS a été mis en

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Springett, Bradley Ross. "Design, synthesis and biological evaluation of inhibitors of polysialyltransferases PST and STX : design, synthesis and biological evaluation of a range of N-modified mannosamines, sialic acids and analogues from in silico screening as inhibitors of PolySia-NCAM biosynthesis with anti-migration activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/13528.

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Abstract:

Polysialylated NCAM (polySia-NCAM) is re-expressed in a number of tumours, including small cell lung carcinoma and neuroblastoma and is strongly associated with aggressive, invasive and metastatic tumours in the clinic. SiRNA knockdown of the polysialyltransferases (polySTs), the enzymes responsible for polysialylation of neural cell adhesion molecule (NCAM), has been shown to abolish cell migration. PolySia-NCAM is thus a highly attractive novel therapeutic target. A library of potential polyST inhibitors has been synthesised, using substrate-based design and computational chemistry. Compound

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