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Relevant bibliographies by topics / N-alkyl derivatives

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Academic literature on the topic 'N-alkyl derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "N-alkyl derivatives"

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Liepa, AJ, AJ Liepa, JS Wilkie, JS Wilkie, KN Winzenberg, and KN Winzenberg. "Preparation of Some 1-Alkyl-4-[1-(ethoxyimino)butyl]-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylic Acid Ester and Amide Herbicides by Reductive Alkylation of 3,5-Dimethoxybenzoic Acid." Australian Journal of Chemistry 42, no. 8 (1989): 1217. http://dx.doi.org/10.1071/ch9891217.

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Reductive alkylation of 3,5-dimethoxybenzoic acid with haloalkanes afforded the 1-alkyl- 3,5-dimethoxycyclohexa-2,5-diene-1-carboxylic acid derivatives (3a-e) which, upon esterification and hydrolysis, furnished methyl 1-alkyl-3-hydroxy-5-oxocyclohex-3-ene-l-carboxylate derivatives (4f-j). Reaction of (4f-j) with butyric anhydride gave methyl 1-alkyl-4-butyryl- 3-hydroxy-5-oxocyclohex-3-ene-1-carboxylate derivatives (6a-e) which were converted into methyl 1-alkyl-4-[1-( ethoxyimino )butyl]-3-hydroxy-5-oxocyclohex-3-ene-1-carbo xyate derivatives (2a-e). Similarly, the oxime O-ether derivative (

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Khvostov, Mikhail V., Elizaveta D. Gladkova, Sergey A. Borisov, et al. "9-N-n-alkyl Berberine Derivatives: Hypoglycemic Activity Evaluation." Pharmaceutics 15, no. 1 (2022): 44. http://dx.doi.org/10.3390/pharmaceutics15010044.

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Several novel 9-N-n-alkyl derivatives of berberine (C5, C7, C10, C12) were synthesized. They were analyzed in vitro and in vivo for their hypoglycemic activity. In vitro studies showed that the derivatives with shorter alkyl substitutes at concentrations ranging from 2.5 to 10 μM were able to stimulate glucose consumption by HepG2 cells more prominently than the derivatives with longer substitutes (C10 and C12). All compounds demonstrated a better effect compared to berberine. Their impact on cells’ viability also depended on the alkyl substitutes length, but in this case, C10 and C12 derivati

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Binzet, Gun, Bülent Zeybek, Esma Kılıç, Nevzat Külcü, and Hakan Arslan. "Determination of the Ionization Constants of Some Benzoyl Thiourea Derivatives in Dioxane-Water Mixture." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/201238.

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The stoichiometric ionization constants ofN,N-dialkyl-N′-(4-substituted benzoyl) thiourea (Substitutes: H, Cl, and Br; alkyl groups: ethyl,n-propyl,n-butyl, and phenyl) derivatives have been determined potentiometrically in dioxane-water (v:v, 50:50) mixture at ionic strength of 0.1 M and25.0±0.1°C. The ionization constants were calculated with the BEST computer program and the formation curves using the data obtained from the potentiometric titrations. The effects of substituents and alkyl groups on the ionization constants of the benzoyl thiourea derivatives have been investigated. A compari

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Jensen, R. T., Z. C. Zhou, R. B. Murphy, et al. "Structural features of various proglumide-related cholecystokinin receptor antagonists." American Journal of Physiology-Gastrointestinal and Liver Physiology 251, no. 6 (1986): G839—G846. http://dx.doi.org/10.1152/ajpgi.1986.251.6.g839.

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Thirteen proglumide derivatives that varied in the length of the di-n-alkyl group and in the substitutions on the benzoyl moiety were tested for their ability to interact with guinea pig pancreatic cholecystokinin (CCK) receptors. Each derivative was more potent than proglumide. There was a close correlation between their abilities to inhibit CCK-stimulated amylase release and to inhibit binding of 125I-CCK. For the di-n-alkyl derivatives the relative potency was n-pentyl greater than n-hexyl greater than n-butyl greater than n-propyl. For the benzoyl moiety, adding two electron-withdrawing gr

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Kalichkina, Liudmila E., Alexander V. Fateev, Polina K. Krivolapenko, et al. "The Study of Structural Features of N- and O-Derivatives of 4,5-Dihydroxyimidazolidine-2-Thione by NMR Spectroscopy and Quantum Chemical Calculations." Magnetochemistry 9, no. 1 (2022): 15. http://dx.doi.org/10.3390/magnetochemistry9010015.

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In the present work, the new N-methylol and O-alkyl derivatives of 4,5-dihydroxyimidazolidine-2-thione (DHIT) are synthesized. The effects of N-alkyl, N-phenyl, N-methylol, and O-alkyl substituents of DHIT on the 13C and 1H signals in NMR spectra of the imidazolidine-2-thione ring are systematized using quantum chemical calculations. The shift values of carbon and hydrogen atoms are specific for the geometric isomers of the indicated DHIT derivatives. The chemical shifts of the carbon atoms of the methine groups allows for identifying the cis and trans isomers of the N-alkyl derivatives of DHI

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Luk'yanov, O. A., G. A. Smirnov, and V. V. Sevost'yanova. "?,?-Dinitro derivatives ofN-alkyl-N?-alkoxydiazene-N-oxides." Russian Chemical Bulletin 44, no. 8 (1995): 1474–78. http://dx.doi.org/10.1007/bf00714433.

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Arsianti, Ade, Norma Nur Azizah, and Linda Erlina. "Molecular docking, ADMET profiling of gallic acid and its derivatives (N-alkyl gallamide) as an anti-breast cancer agent." F1000Research 11 (December 8, 2022): 1453. http://dx.doi.org/10.12688/f1000research.127347.1.

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Background In 2020, breast cancer has become the most common cancer in the world and in Indonesia. Searching for anticancer drugs using computational methods is considered more effective and selective than other methods. Gallic acid and its derivatives (esters and amides) are compounds that have biological activities such as anticancer effects. The purpose of this study was to analyse the molecular modelling and ADMET (Adsorption, Distribution, Metabolism, Excretion and Toxicity) profile of gallic acid derivative compounds (N-alkyl gallamides) as anticancer agents. Methods Target proteins were

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Moribe, Kunikazu, Waree Limwikrant, Kenjirou Higashi, and Keiji Yamamoto. "Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives." Journal of Drug Delivery 2011 (April 26, 2011): 1–9. http://dx.doi.org/10.1155/2011/138929.

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Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients. In addition to drug solubilization, drug nanoparticle formation was observed using ascorbyl glycoside. Hydrophobic ascorbic acid derivatives such as ascorbyl mono- and di-n-alkyl fatty acid derivatives are used either as drugs or carrier components. Ascorbyl n-alkyl fatty acid derivatives have been formulated as antioxidants or

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Burgess, VA, та CJ Easton. "Reaction of N-Benzoyl-2-bromoglycine Methyl Ester With Deprotonated Nitroalkanes: Synthesis of β-Nitro and α,β-Dehydro Amino Acid Derivatives". Australian Journal of Chemistry 41, № 7 (1988): 1063. http://dx.doi.org/10.1071/ch9881063.

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N-Benzoyl-2-bromoglycine methyl ester (1) reacted with the alkyl nitronates (2a-e) to give the corresponding β-nitro amino acid derivatives (4a-e). Elimination reactions of (4a-d) afforded the α,β-dehydro amino acid derivatives (5a-d). Treatment of the β- nitrovaline derivative (4b) with tributyltin hydride gave the valine derivative (8). Reduction of the β- nitroalanine derivative (4a) gave the β- aminoalanine derivative (9), characterized by hydrolysis to 2,3- diaminopropionic acid hydrochloride.

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Ghandi, Mehdi, Parham Asgari, Abuzar Taheri, and Alireza Abbasi. "One-pot, three-component condensation of 2-hydroxybenzaldehyde derivatives, primary amines with alkyl isocyanides to N-alkyl-2-(2-hydroxyphenyl)-2-imino-acetamides." Open Chemistry 8, no. 4 (2010): 899–905. http://dx.doi.org/10.2478/s11532-010-0054-7.

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AbstractOne-pot, three-component condensation of 2-hydroxybenzaldehyde derivatives, primary amines with alkyl isocyanides is reported. N-alkyl-2-(2-hydroxyphenyl)-2-iminoacetamide derivatives are generated presumably via the preliminary formation of N, N′-disubstituted benzo[b]furan-2,3-diamines and subsequent oxidation with molecular oxygen.

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More sources

Dissertations / Theses on the topic "N-alkyl derivatives"

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Patel, Divya. "The synthesis and rearrangement of N-alkyl-O-acyl hydroxamic acid derivatives." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400109.

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Baeza, Mario Ivan. "Synthesis and characterization of acetylenic derivatives of the actinide extractant (aryl)-N,N-di-(alkyl)carbamoylmethylphosphine oxide (CMPO)." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2008. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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Marcadal-Abbadi, Céline. "Radicaux organiques et catalyse : nouveaux systèmes d'oxydation d'alcanes activés ; synthèse et mise en oeuvre de N-hydroxyimides chiraux." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10257.

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Le n-hydroxyphtalimide (nhpi) est capable de catalyser l'oxydation aerobie d'une grande variete de substrats organiques en particulier les alkylbenzenes via le radical phtalimide-n-oxyle (pino). Deux nouveaux systemes catalytiques utilisant le nhpi ont ete mis au point. Ils fonctionnent a pression et temperature ambiantes. Le premier, base sur une double catalyse, met en jeu le chlorure cuivreux et l'oxygene moleculaire. Le second met en oeuvre l'autoxydation de l'acetaldehyde. Ces deux systemes fournissent majoritairement les aryls cetones a partir des hydrocarbures benzyliques avec de bons r

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Zhou, Honggang. "Mesure et modélisation de la masse volumique et de la viscosité d'hydrocarbures et de leurs mélanges en fonction de la pression." Pau, 1988. http://www.theses.fr/1988PAUU3005.

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La viscosité dynamique de six n-alcanes, de trois alkylbenzènes et de mélanges binaires et quaternaires d'alcanes est mesurée a l'aide d'un viscosimètre a corps chutant, à différentes températures et des pressions allant jusqu'a 1000 bars. Plusieurs modèles, reliant la viscosité a la température, a la pression et a d'autres grandeurs caractéristiques des produits sont proposes et compares. Une nouvelle méthode de calcul de la masse volumique basee sur l'équation d'état de simha est developpée. Elle est appliquée au calcul de la masse volumique de cinq alkylbenzènes. Les résultats sont en très

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Nagaraja, P. "N-Alkyl derivatives of Phemothiazine as Spectrophotometric Reagents." Thesis, 1985. http://hdl.handle.net/2009/2352.

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Chiu, Ying-Chang, and 邱盈彰. "Metallomesogens based on N-(2-hydroxy)alkyl substituted imidazole derivatives." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/24548624483347290155.

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博士<br>國立東華大學<br>化學系<br>97<br>Metallomesogens of the types (i) N-(2-hydroxyl)alkyl imidazole coordinated with Silver(I), Gold(I), and Palladium(II) ions (in Chapter II), (ii) Silver(I) and Gold(I) complexes of N-hexadecanyl-N´-(2-hydroxyhexadecanyl) imidazol-2-ylidenes (in Chapter III), and (iii) nanocomposites of Gold nanoparticles embedded in N,N´-di-substituted imidazolium salt (in Chapter IV) are presented. The characterizations, results, and discussions are described in each section.

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張元軍. "Synthesis of N-alkyl Iminoalditol and pyrrolidine derivatives as Glycosidase Inhibitors." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/83759606820380930634.

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碩士<br>國立彰化師範大學<br>化學系<br>97<br>The goals of our research are to synthesize glycosidase inhibitors. The first project is using D-ribose as starting material to synthesize the derivatives of ribopyranoside. We are successful to obtain the target compound methyl 2-C-(5-deoxy-2,3-di-O-isopropylidene-5 morpholinopropylamino-β-D-ribopyranosyl) acetate 7, methyl 2-C-(5-deoxy-2,3-di-O-isopropylidene-5-decylamino-β-Dribopyranosyl) acetate 9, 2-C-(5-deoxy-2,3-di-O-isopropylidene-5-morpholinopropyl amino-β-D-ribopyranosyl)ethanol 8, and 2-C-(5-deoxy-2,3-di-O-isopropylidene-5- decylamino -β-D-ribopyranosy

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Huei, Shiu Ya, and 許雅惠. "Synthesis and Antiproliferative Evaluation of N-Alkyl-4-anilinofuro[2,3-b]quinoline Derivatives." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/82408015828683668853.

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碩士<br>高雄醫學大學<br>藥學研究所<br>99<br>The skeleton of natural dictamnine alkaloid belongs to a tricyclic furoquinoline derivative. Previous reports indicated that the introduction of a suitable substituent at the 4-position of furoquinoline ring afforded certain potential antiproliferative agents. For examples, 1-[4-(furo[2,3-b]quinoline-4-ylamino)phenyl]ethanone (1, GI50 = 0.025 μM) and 3-chloro-4-[(4-methoxyphenyl)amino]furo[2,3-b]quinoline (2, GI50 = 0.025 μM) exhibited more potent antiproliferative activities than the clinically used anticancer drug, daunomycin. However, poor water solubility and

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Book chapters on the topic "N-alkyl derivatives"

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Legler, Günter, and Harald Liedtke. "β-Glucocerebrosidase: Affinity Purification and Characterization of its Active Site with N-Alkyl Derivatives of 1-Deoxynojirimycin." In Enzymes of Lipid Metabolism II. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5212-9_40.

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Park, J. M., and J. D. Andrade. "Dynamic Contact Angle Studies of N-Alkyl Derivatized Boro-Silicate Glass Surfaces." In Polymer Surface Dynamics. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-1291-8_5.

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"8.6 N-Alkyl Derivatives." In Protecting Groups, edited by Philip J. Kocieński. Georg Thieme Verlag, 2005. http://dx.doi.org/10.1055/b-0035-108300.

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Kollenz, G. "N-Unsubstituted and -Alkyl-Substituted Imidoylketenes." In Three Carbon-Heteroatom Bonds: Thio-, Seleno-, and Tellurocarboxylic Acids and Derivatives; Imidic Acids and Derivatives; Ortho Acid Derivatives. Georg Thieme Verlag KG, 2006. http://dx.doi.org/10.1055/sos-sd-023-00343.

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Barrett, Graham c. "Mono- and di-alkylation of the amino group." In Amino Acid Derivatives. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780198558538.003.0004.

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Abstract The prolonged reaction of an amino acid in solution with an alkyl halide leads to mixtures of secondary and tertiary amines. Continued alkylation ultimately generates the corresponding quaternary ammonium salt of the amino acid ester. This is an inefficient process in terms of organic synthesis, and reliable routes to N-alkylamino acids call for a more painstaking, less direct, approach. Reaction of an amino acid with an aldehyde, followed by reduction of the resulting alkylol or Schiff base, has been found to be reliable, although it is not often used. Weinreb and co-workers showed t

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Blakemore, P. R. "N-Acylation of -Alkyl or -Silyl Hydroxylamine Derivatives." In Three Carbon-Heteroatom Bonds: Esters and Lactones; Peroxy Acids and R(CO)OX Compounds; R(CO)X, X=S, Se, Te. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-021-00883.

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"Purine and C -Alkyl, C -Aryl, and N -Alkyl Derivatives (H 117)." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470187944.ch4.

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Okusecyama, Tadashi, and Howard Maskill. "Nucleophilic Substitution Reactions of Carboxylic Acid Derivatives." In Organic Chemistry. Oxford University Press, 2013. http://dx.doi.org/10.1093/hesc/9780199693276.003.0009.

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This chapter concentrates on the interconversions of carboxylic acid derivatives, which generally take place by nucleophilic substitution via addition-elimination mechanisms. It first describes carboxylic acids which contain a carboxy functional group (a carbonyl with a hydroxy group attached) bonded to an alkyl residue. Carboxylic acid derivatives, on the other hand, are obtained by replacing the hydroxy with another group bonded through O, N, S, or halogen. This class of compounds includes esters (Y = OR'), anhydrides (Y = OCOR'), amides (Y = NR' 2), and acyl halides (Y = halogen). The chapt

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Töjrnqvist, M. "The N-alkyl Edman method for haemoglobin adduct measurement: updating and applications to humans." In Human Carcinogen Exposure. Oxford University PressOxford, 1991. http://dx.doi.org/10.1093/oso/9780199631858.003.0037.

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Abstract The N-alkyl Edman method, a modification of the Edman degradation method, was developed for specific determination of adducts to the Nterminal valine in haemoglobin (Hb). Later improvements of the method with respect of sensitivity, reproducibility, etc., have been summarized.4-5 The derivatives of the alkylvalines, the pentafluorophenylthiohydantoins (PFPTHs) are determined by gas chromatography/mass spectrometry (GC-MS) with chemical ionization in the negative ion mode, monitoring characteristic fragments.

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Cordero, F. M., and S. Cicchi. "Reaction of N-Substituted Hydroxylamines with Alkyl Cyanoformates." In Three Carbon-Heteroatom Bonds: Amides and Derivatives; Peptides; Lactams. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-022-00400.

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Conference papers on the topic "N-alkyl derivatives"

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Soriaga, Manuel P., G. M. Berry, C. Bhardwaj, et al. "Chemisorption of Organic Molecules on Metal Electrode Surfaces." In CORROSION 1990. NACE International, 1990. https://doi.org/10.5006/c1990-90300.

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Abstract The chemisorption of various organic functional groups from aqueous solutions onto smooth single-crystal and polycrystalline electrodes, and the resistance of the resulting monolayer intermediates towards electrochemical oxidation have been studied; these investigations were motivated by the need to understand, at the atomic level, metal passivation by monolayer organic coatings. The electrodes employed were Rh, Pd, Ir, Pt, and Au whose anodic dissolution is preceded by surface-oxide formation even in highly acidic media. Resistance towards anodic oxidation can thus be associated with

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Gowdahalli, Krishnegowda, A. S. Prakasha Gowda, Hephzibah Rani S. Tagaram, Arun K. Sharma, and Shantu Amin. "Abstract 2131: Synthesis and biological evaluation of novel N-alkyl derivatives of 5, 7-dibromoisatin as potent anticancer agents." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2131.

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BinGhanim, Ahmed, Jawad Al-Darweesh, Murtada S. Aljawad, et al. "Rheological Optimization of CO2 Foamed Chelating Stimulation Fluids at High-Pressure, High-Temperature, and Salinity." In International Petroleum Technology Conference. IPTC, 2022. http://dx.doi.org/10.2523/iptc-22485-ms.

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Abstract Foamed acidic fluids have been utilized in the industry for enhanced oil recovery and fracturing applications due to their various advantages. Flowback enhancement, recovery of treatment fluids, and reduction of overall water consumption per operation are examples of these advantages. This study examines the utilization of a chelating agent, L-glutamic acid-N, N-diacetic acid (GLDA) in N2 and CO2 foamed fluids, which enhances the stability of foamed acidic fluids, lowers corrosion tendency, and is environmentally friendly. A modified high pressure and high temperature (HPHT) foam rheo

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