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Journal articles on the topic 'N-alkyl derivatives'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Liepa, AJ, AJ Liepa, JS Wilkie, JS Wilkie, KN Winzenberg, and KN Winzenberg. "Preparation of Some 1-Alkyl-4-[1-(ethoxyimino)butyl]-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylic Acid Ester and Amide Herbicides by Reductive Alkylation of 3,5-Dimethoxybenzoic Acid." Australian Journal of Chemistry 42, no. 8 (1989): 1217. http://dx.doi.org/10.1071/ch9891217.

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Reductive alkylation of 3,5-dimethoxybenzoic acid with haloalkanes afforded the 1-alkyl- 3,5-dimethoxycyclohexa-2,5-diene-1-carboxylic acid derivatives (3a-e) which, upon esterification and hydrolysis, furnished methyl 1-alkyl-3-hydroxy-5-oxocyclohex-3-ene-l-carboxylate derivatives (4f-j). Reaction of (4f-j) with butyric anhydride gave methyl 1-alkyl-4-butyryl- 3-hydroxy-5-oxocyclohex-3-ene-1-carboxylate derivatives (6a-e) which were converted into methyl 1-alkyl-4-[1-( ethoxyimino )butyl]-3-hydroxy-5-oxocyclohex-3-ene-1-carbo xyate derivatives (2a-e). Similarly, the oxime O-ether derivative (

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2

Khvostov, Mikhail V., Elizaveta D. Gladkova, Sergey A. Borisov, et al. "9-N-n-alkyl Berberine Derivatives: Hypoglycemic Activity Evaluation." Pharmaceutics 15, no. 1 (2022): 44. http://dx.doi.org/10.3390/pharmaceutics15010044.

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Several novel 9-N-n-alkyl derivatives of berberine (C5, C7, C10, C12) were synthesized. They were analyzed in vitro and in vivo for their hypoglycemic activity. In vitro studies showed that the derivatives with shorter alkyl substitutes at concentrations ranging from 2.5 to 10 μM were able to stimulate glucose consumption by HepG2 cells more prominently than the derivatives with longer substitutes (C10 and C12). All compounds demonstrated a better effect compared to berberine. Their impact on cells’ viability also depended on the alkyl substitutes length, but in this case, C10 and C12 derivati

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3

Binzet, Gun, Bülent Zeybek, Esma Kılıç, Nevzat Külcü, and Hakan Arslan. "Determination of the Ionization Constants of Some Benzoyl Thiourea Derivatives in Dioxane-Water Mixture." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/201238.

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The stoichiometric ionization constants ofN,N-dialkyl-N′-(4-substituted benzoyl) thiourea (Substitutes: H, Cl, and Br; alkyl groups: ethyl,n-propyl,n-butyl, and phenyl) derivatives have been determined potentiometrically in dioxane-water (v:v, 50:50) mixture at ionic strength of 0.1 M and25.0±0.1°C. The ionization constants were calculated with the BEST computer program and the formation curves using the data obtained from the potentiometric titrations. The effects of substituents and alkyl groups on the ionization constants of the benzoyl thiourea derivatives have been investigated. A compari

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4

Jensen, R. T., Z. C. Zhou, R. B. Murphy, et al. "Structural features of various proglumide-related cholecystokinin receptor antagonists." American Journal of Physiology-Gastrointestinal and Liver Physiology 251, no. 6 (1986): G839—G846. http://dx.doi.org/10.1152/ajpgi.1986.251.6.g839.

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Thirteen proglumide derivatives that varied in the length of the di-n-alkyl group and in the substitutions on the benzoyl moiety were tested for their ability to interact with guinea pig pancreatic cholecystokinin (CCK) receptors. Each derivative was more potent than proglumide. There was a close correlation between their abilities to inhibit CCK-stimulated amylase release and to inhibit binding of 125I-CCK. For the di-n-alkyl derivatives the relative potency was n-pentyl greater than n-hexyl greater than n-butyl greater than n-propyl. For the benzoyl moiety, adding two electron-withdrawing gr

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5

Kalichkina, Liudmila E., Alexander V. Fateev, Polina K. Krivolapenko, et al. "The Study of Structural Features of N- and O-Derivatives of 4,5-Dihydroxyimidazolidine-2-Thione by NMR Spectroscopy and Quantum Chemical Calculations." Magnetochemistry 9, no. 1 (2022): 15. http://dx.doi.org/10.3390/magnetochemistry9010015.

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In the present work, the new N-methylol and O-alkyl derivatives of 4,5-dihydroxyimidazolidine-2-thione (DHIT) are synthesized. The effects of N-alkyl, N-phenyl, N-methylol, and O-alkyl substituents of DHIT on the 13C and 1H signals in NMR spectra of the imidazolidine-2-thione ring are systematized using quantum chemical calculations. The shift values of carbon and hydrogen atoms are specific for the geometric isomers of the indicated DHIT derivatives. The chemical shifts of the carbon atoms of the methine groups allows for identifying the cis and trans isomers of the N-alkyl derivatives of DHI

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6

Luk'yanov, O. A., G. A. Smirnov, and V. V. Sevost'yanova. "?,?-Dinitro derivatives ofN-alkyl-N?-alkoxydiazene-N-oxides." Russian Chemical Bulletin 44, no. 8 (1995): 1474–78. http://dx.doi.org/10.1007/bf00714433.

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7

Arsianti, Ade, Norma Nur Azizah, and Linda Erlina. "Molecular docking, ADMET profiling of gallic acid and its derivatives (N-alkyl gallamide) as an anti-breast cancer agent." F1000Research 11 (December 8, 2022): 1453. http://dx.doi.org/10.12688/f1000research.127347.1.

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Background In 2020, breast cancer has become the most common cancer in the world and in Indonesia. Searching for anticancer drugs using computational methods is considered more effective and selective than other methods. Gallic acid and its derivatives (esters and amides) are compounds that have biological activities such as anticancer effects. The purpose of this study was to analyse the molecular modelling and ADMET (Adsorption, Distribution, Metabolism, Excretion and Toxicity) profile of gallic acid derivative compounds (N-alkyl gallamides) as anticancer agents. Methods Target proteins were

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8

Moribe, Kunikazu, Waree Limwikrant, Kenjirou Higashi, and Keiji Yamamoto. "Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives." Journal of Drug Delivery 2011 (April 26, 2011): 1–9. http://dx.doi.org/10.1155/2011/138929.

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Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients. In addition to drug solubilization, drug nanoparticle formation was observed using ascorbyl glycoside. Hydrophobic ascorbic acid derivatives such as ascorbyl mono- and di-n-alkyl fatty acid derivatives are used either as drugs or carrier components. Ascorbyl n-alkyl fatty acid derivatives have been formulated as antioxidants or

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9

Burgess, VA, та CJ Easton. "Reaction of N-Benzoyl-2-bromoglycine Methyl Ester With Deprotonated Nitroalkanes: Synthesis of β-Nitro and α,β-Dehydro Amino Acid Derivatives". Australian Journal of Chemistry 41, № 7 (1988): 1063. http://dx.doi.org/10.1071/ch9881063.

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N-Benzoyl-2-bromoglycine methyl ester (1) reacted with the alkyl nitronates (2a-e) to give the corresponding β-nitro amino acid derivatives (4a-e). Elimination reactions of (4a-d) afforded the α,β-dehydro amino acid derivatives (5a-d). Treatment of the β- nitrovaline derivative (4b) with tributyltin hydride gave the valine derivative (8). Reduction of the β- nitroalanine derivative (4a) gave the β- aminoalanine derivative (9), characterized by hydrolysis to 2,3- diaminopropionic acid hydrochloride.

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10

Ghandi, Mehdi, Parham Asgari, Abuzar Taheri, and Alireza Abbasi. "One-pot, three-component condensation of 2-hydroxybenzaldehyde derivatives, primary amines with alkyl isocyanides to N-alkyl-2-(2-hydroxyphenyl)-2-imino-acetamides." Open Chemistry 8, no. 4 (2010): 899–905. http://dx.doi.org/10.2478/s11532-010-0054-7.

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AbstractOne-pot, three-component condensation of 2-hydroxybenzaldehyde derivatives, primary amines with alkyl isocyanides is reported. N-alkyl-2-(2-hydroxyphenyl)-2-iminoacetamide derivatives are generated presumably via the preliminary formation of N, N′-disubstituted benzo[b]furan-2,3-diamines and subsequent oxidation with molecular oxygen.

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11

Pradip, P. Deohate, and N. Berad B. "Synthesis, characterization and antimicrobial study of substituted bis-[1 ,3,4]-oxadiazole, bis-[1 ,3,4]-thiadiazole and bis-[1,2,4]-triazole derivatives." Journal of Indian Chemical Society Vol. 85, Nov 2008 (2008): 1153–58. https://doi.org/10.5281/zenodo.5820567.

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Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001, Maharashtra, India <em>E-mail</em> : pradip22209l@yahoo.co.in Postgraduate Department of Chemistry, Shri Shivaji Science College, Amravati-444 603, Maharashtra, India <em>Manuscript received 29 April 2008, accepted 16 July 2008</em> Series of compounds 1,4-bis-(2-aryl/alky1-amino-[1,3,4]-oxadiazol-5-yI)-benzenes, 1,4-bis-(2-aryl/alkyl-amino[ 1,3,4]-thiadiazol-5-yl)-benzenes and 1,4-bis-(3-mercapto-4-aryl/alkyl-[1,2,4]-triazol-5-yl)-benzenes have been synthesized by the oxidative cyclization of di

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12

Šafář, Peter, František Považanec, Pavel Čepec, and Naďa Prónayová. "Preparation of Derivatives of 2-Cyano-3-(5-N-arylamino- or 5-N-Alkyl-N-phenylamino-2-furyl)propenoic Acids." Collection of Czechoslovak Chemical Communications 62, no. 7 (1997): 1105–13. http://dx.doi.org/10.1135/cccc19971105.

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(5-Bromo-2-furyl)methylidenemalonodinitrile (1) reacted with substituted aromatic amines under formation of (5-N-arylamino-2-furyl)methylidenemalonodinitriles 2a-2h whereas no reaction was observed with N-alkyl-N-phenylamines. Derivatives of 2-cyano-3-(5-N-alkyl-N-phenylamino-2-furyl)- propenoic acid 5a-5o were prepared by reaction of the corresponding N-alkylanilines with 5-bromo-2-furancarbaldehyde, followed by hydrolysis of the obtained Eiji salts and reaction with malonic acid derivatives.

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13

Arsianti, Ade, Norma Nur Azizah, and Linda Erlina. "Molecular docking, ADMET profiling of gallic acid and its derivatives (N-alkyl gallamide) as apoptosis agent of breast cancer MCF-7 Cells." F1000Research 11 (February 8, 2024): 1453. http://dx.doi.org/10.12688/f1000research.127347.3.

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Background In 2020, breast cancer has become the most common cancer in the world and in Indonesia. Searching for anticancer drugs using computational methods is considered more effective and selective than other methods. Gallic acid and its derivatives (esters and amides) are compounds that have biological activities such as anticancer effects. The purpose of this study was to analyse the molecular modelling and ADMET (Adsorption, Distribution, Metabolism, Excretion and Toxicity) profile of gallic acid derivative compounds (N-alkyl gallamides) as anticancer agents. Methods Target proteins were

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14

Buján, Elba I., and María Laura Salum. "A simple synthesis of benzimidazole N-oxides from 2-nitroaniline derivatives Scope and limitations." Canadian Journal of Chemistry 82, no. 8 (2004): 1322–27. http://dx.doi.org/10.1139/v04-083.

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Several benzimidazole N-oxide derivatives were synthesized in very good yield by heating at reflux the corresponding N-alkyl-2-nitroaniline derivative with NaOH in 60% 1,4-dioxanewater. The effect of substituents on the aromatic ring and amino group on the reaction is discussed.Key words: synthesis, benzimidazole N-oxides.

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15

Pradip, P. Deohate. "Substituted [1,3,4]-oxadiazole, [1,3,4]-thiadiazole and [1,2,4]-triazole; synthesis, characterization and antimicrobial study." Journal of Indian Chemical Society Vol. 89, Feb 2012 (2012): 253–59. https://doi.org/10.5281/zenodo.5759585.

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Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001, Maharashtra, India <em>E-mail</em> : pradip222091@yahoo.co.in <em>Manuscript received 06 August 2009, revised 29 December 2010, accepted 20 June 2011</em> Series of compounds 5-(benzotriazol-1-yl-methyl)-2-aryl/alkyl-amino-[1 ,3,4]-oxadiazoles, 5-(benzotriazol-1-yl-methyl)-2-ary 1/ alky 1-amino-[1 ,3, 4]-thiadiazoles and 5-(benzotriazol-1-yl-methyl)-3-merca pto-4-aryl/ alkyl-4<em>H</em>-[1 ,2 ,4]-triazoles have been synthesized by the oxidative cyclization of 2-benzotriazol-1-yl-<em>N</em>-aryl/a

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16

Holý, Antonín, Joachim König, Jiří Veselý, Dieter Cech, Ivan Votruba, and Erik De Clercq. "5'-O-Alkyl-5-fluorouridines: Synthesis and biological activity." Collection of Czechoslovak Chemical Communications 52, no. 6 (1987): 1589–608. http://dx.doi.org/10.1135/cccc19871589.

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Methyl 2,3-O-isopropylidene-D-ribofuranoside (IV) was alkylated with alkyl halides in the presence of sodium hydride and the products were transformed by acid hydrolysis and glycosylation into methyl 5-O-alkyl-D-ribofuranosides VII. Benzoylation of VII followed by acetolysis afforded 1-O-acetyl-2,3-di-O-benzoyl-5-O-alkyl-D-ribofuranoses IX which on reaction with 2,4-bis(trimethylsilyloxy)pyrimidine in the presence of tin tetrachloride in acetonitrile and subsequent hydrolysis gave 5'-O-alkyl-2',3'-di-O-benzoyluridines XIa-XIe. Methanolysis of compounds XI furnished 5'-O-alkyluridines III. The

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17

Bretner, Maria, Andrea Baier, Katarzyna Kopańska, et al. "Synthesis and Biological Activity of 1H-benzotriazole and 1H-benzimidazole Analogues — Inhibitors of the NTPase/Helicase of HCV and of Some Related Flaviviridae." Antiviral Chemistry and Chemotherapy 16, no. 5 (2005): 315–26. http://dx.doi.org/10.1177/095632020501600504.

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To improve anti-helical activity of analogues of 1 H-benzotriazole and 1 H-benzimidazole their N-alkyl derivatives were synthesized and tested for anti-helicase activity against enzymes of selected Flaviviridae including hepatitis C virus (HCV), West Nile virus (WNV), Dengue virus (DENV) and Japanese encephalitis virus (JEV). 1- and 2-alkyl derivatives of 4,5,6,7-tetrabromo-1 H-benzotriazole were obtained by direct alkylation of 4,5,6,7-tetrabromo-1 H-benzotriazole with the use of respective alkyl halides in the presence of KOH in methanol, to give a mixture of 1- and 2- isomers, which was sep

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18

Pinheiro, Daniela, Marta Pineiro, Adelino M. Galvão, and J. Sérgio Seixas de Melo. "Deep in blue with green chemistry: influence of solvent and chain length on the behaviour of N- and N,N′- alkyl indigo derivatives." Chemical Science 12, no. 1 (2021): 303–13. http://dx.doi.org/10.1039/d0sc04958a.

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Using green chemistry procedures the synthesis of N- and N,N′-alkyl indigo derivatives was undertaken and the effect of the alkyl chain length on the spectral (including color) and photophysical properties of the compounds explored.

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19

Mikhina, Ekaterina A., Daria V. Stepanycheva, Varvara P. Maksimova, et al. "Synthesis of Alkyl/Aryloxymethyl Derivatives of 1,2,4-Triazole-3-Carboxamides and Their Biological Activities." Molecules 29, no. 20 (2024): 4808. http://dx.doi.org/10.3390/molecules29204808.

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Ribavirin and its analogues exhibit an in vitro antiproliferative effect in cancer cells. In this work, we studied the biological activities of a number of alkyl/aryloxymethyl derivatives of ribavirin’s aglycon—1,2,4-triazole-3-carboxamide. Alkyl/arylxymethyl derivatives of 1,2,4-triazole-3-carboxamide with substitutions at the fifth or first position of the triazole ring, were synthesized and their antiproliferative and antimicrobial effects were assessed. For both series, the presence of an antiproliferative effect was investigated, and 1-alkyl/aryloxymethyl derivatives were shown an antimic

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20

NUMAZAWA, Mitsuteru, Akiko YOSHIMURA, and Mariko OSHIBE. "Enzymic aromatization of 6-alkyl-substituted androgens, potent competitive and mechanism-based inhibitors of aromatase." Biochemical Journal 329, no. 1 (1998): 151–56. http://dx.doi.org/10.1042/bj3290151.

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To gain insight into the relationships between the aromatase inhibitory activity of 6-alkyl-substituted androgens, potent competitive inhibitors, and their ability to serve as a substrate of aromatase, we studied the aromatization of a series of 6α- and 6β-alkyl (methyl, ethyl, n-propyl, n-pentyl and n-heptyl)-substituted androst-4-ene-3,17-diones (ADs) and their androsta-1,4-diene-3,17-dione (ADD) derivatives with human placental aromatase, by gas chromatography-mass spectrometry. Among the inhibitors examined, ADD and its 6α-alkyl derivatives with alkyl functions less than three carbons long

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21

Banert, Klaus, Katharina Fink, Manfred Hagedorn, and Frank Richter. "Synthesis of triacetonamine N-alkyl derivatives reinvestigated." Arkivoc 2012, no. 3 (2012): 379–90. http://dx.doi.org/10.3998/ark.5550190.0013.327.

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22

Dao, Phi Thi. "SYNTHESIS OF N-ALKYL AMINO LACTAM DERIVATIVES." Vietnam Journal of Science and Technology 54, no. 2C (2018): 291. http://dx.doi.org/10.15625/2525-2518/54/2c/11849.

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Bengamides are sponge-derived natural products of mixed biosynthesis (polyketides andamino acids), the first two members, isolated from Jaspidae sponges in coral surrounding Fijiislands, were reported in 1986. The main structural variation is located on the 3-aminocaprolactam moiety, and displays a wide range of biological activities, includingantitumor, antibiotic, and anthelmintic properties. These interesting biological activities havemade bengamides popular targets for synthesis and biological studies. There have been somereports on diverse modifications of the caprolactame unit, and indic

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23

Krokidis, Marios G., Zara Molphy, Eleni K. Efthimiadou, et al. "Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes." Biomolecules 9, no. 5 (2019): 177. http://dx.doi.org/10.3390/biom9050177.

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The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have been developed and evaluated for their anti-cancer properties. A series of N-alkyl-acridones 1–6 and N,N′-dialkyl-9,9′-biacridylidenes 7–12 with variable alkyl chains were examined for their topoisomerase I activity at neutral and acidic conditions as well as for their binding capacity to calf thymus and possible radical trapping antioxidant activity. It was found that at a neutral pH, topoisomerase I activity of both classes of compounds

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24

Nishiwaki, Hisashi, Megumi Ikari, Satomi Fujiwara, et al. "Cytotoxicity against HL60 Cells of Ficifolidione Derivatives with Methyl, n-Pentyl, and n-Heptyl Groups." Molecules 24, no. 22 (2019): 4081. http://dx.doi.org/10.3390/molecules24224081.

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Ficifolidione, a natural insecticidal compound isolated from the essential oils of Myetaceae species, is a spiro phloroglucinol with an isobutyl group at the C-4 position. We found that ficifolidione showed cytotoxicity against cancer cells via apoptosis. Replacement of the isobutyl group by n-propyl group did not influence the potency, but the effect of the replacement of this group by a shorter or longer alkyl group on the biological activity remains unknown. In this study, ficifolidione derivatives with alkyl groups such as methyl, n-pentyl, and n-heptyl group—instead of the isobutyl group

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25

Zenkevich, Igor G., Nino G. Todua, and Anzor I. Mikaia. "Unusual Regularity in GC Retention of Simple Amino Acid Derivatives." Current Chromatography 6, no. 1 (2019): 3–14. http://dx.doi.org/10.2174/2213240606666190709100858.

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Background: Application of simple regularities and general principles along with direct use of reference gas chromatography retention index data for reliable structure determination of compounds can be enhanced by determination of new regularities that are specific to certain structural elements. Objective: Revelation and interpretation of an anomaly in the elution order of alkyl esters of alkoxycarbonyl derivatives of glycine and alanine on standard and semi-standard non-polar phases. Method: Preliminary derivatization of amino acids to alkyl esters of N-alkoxycarbonyl analogs and interpretat

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26

Liu, Qili, Jianxin Zhang, Dong Li, et al. "Inhibition of Amphiphilic N-Alkyl-O-carboxymethyl Chitosan Derivatives on Alternaria macrospora." BioMed Research International 2018 (June 11, 2018): 1–9. http://dx.doi.org/10.1155/2018/5236324.

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Cotton leaf spot (Alternaria macrospora) is a widespread disease that occurs in the main cotton-producing area of China. In managing this disease, a novel chitosan-based biopesticide, an amphiphilic N-alkyl-O-carboxymethyl chitosan derivative, was prepared. The product was selected from variations of chitosan with different molecular structures, which were obtained via a two-step reaction. First, carboxymethyl chitosans with varying molecular sizes were obtained by etherification with chloroacetic acid; then the carboxymethyl chitosan was alkylated with C4–C12 fatty aldehyde through a Schiff-b

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27

Stanciu, Magdalena-Cristina, Marieta Nichifor, Gabriela-Liliana Ailiesei, et al. "New Quaternary Ammonium Derivatives Based on Citrus Pectin." Polymers 15, no. 23 (2023): 4492. http://dx.doi.org/10.3390/polym15234492.

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New citrus pectin derivatives carrying pendant N,N-dimethyl-N-alkyl-N-(2-hydroxy propyl) ammonium chloride groups were achieved via polysaccharide derivatization with a mixture of N,N-dimethyl-N-alkyl amine (alkyl = ethyl, butyl, benzyl, octyl, dodecyl) and epichlorohydrin in aqueous solution. The structural characteristics of the polymers were examined via elemental analysis, conductometric titration, Fourier Transform Infrared spectroscopy (FTIR) and 1D (1H and 13C) nuclear magnetic resonance (NMR). Capillary viscosity measurements allowed for the study of viscometric behavior as well as the

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Zug, Ines, and Horst Hartmann. "Preparation and Characterisation of N,N-Disubstituted 2-Amino-5H-selenophenes." Zeitschrift für Naturforschung B 59, no. 4 (2004): 439–42. http://dx.doi.org/10.1515/znb-2004-0412.

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AbstractThe reaction of N,N’-persubstituted selenoacrylamides with alkyl bromoacetates gives rise to the formation of alkyl derivatives of N,N-disubstituted 2-aminoselenophene-5-carboxylates which can be transformed by saponification into corresponding 5-carboxylic acids. These compounds decompose by heating under formation of hitherto unknown N,N-disubstituted 2-amino-5H-selenophenes their spectral and chemical properties were outlined.

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Rubekina, Anna A., Polina N. Kamzeeva, Vera A. Alferova, et al. "Hydrophobic Rose Bengal Derivatives Exhibit Submicromolar-to-Subnanomolar Activity against Enveloped Viruses." Biomolecules 12, no. 11 (2022): 1609. http://dx.doi.org/10.3390/biom12111609.

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Rose Bengal (RB) is an anionic xanthene dye with multiple useful biological features, including photosensitization properties. RB was studied extensively as a photosensitizer, mostly for antibacterial and antitumor photodynamic therapy (PDT). The application of RB to virus inactivation is rather understudied, and no RB derivatives have been developed as antivirals. In this work, we used a synthetic approach based on a successful design of photosensitizing antivirals to produce RB derivatives for virus photoinactivation. A series of n-alkyl-substituted RB derivatives was synthesized and evaluat

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Rybár, Alfonz, Dušan Hesek, Fridrich Szemes, Juraj Alföldi, and Marian Tegza. "3,7-Dialkyl-8-alkyl- or -aryl-3,7-dihydropurine-2,6-diones." Collection of Czechoslovak Chemical Communications 55, no. 9 (1990): 2257–69. http://dx.doi.org/10.1135/cccc19902257.

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3,7-Dialkyl-8-alkyl- or -aryl-3,7-dihydropurine-2,6-diones XII-XIV were synthesized from 5-alkylamino-6-amino-1-alkyl-2,4(1H,3H)-pyrimidinediones VII-IX by three methods: the first is based upon an acid catalyzed cyclization of the starting derivatives VII-IX with orthoesters of carboxylic acids in dimethylformamide. In the second and third methods the 5-((N-acyl)(N-alkyl)amino) derivatives X, XI, obtained by acylation of VII-IX were cyclized either in aqueous solution of alkali metal hydroxides, or in dimethylformamide in the presence of alkali metal hydroxides, or in dimethylformamide in the

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31

Wijayanti, Mahardika Agus, Eti Nurwening Sholikhah, Ruslin Hadanu, Jumina Jumina, Supargiyono Supargiyono, and Mustofa Mustofa. "Additive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64." Malaria Research and Treatment 2010 (June 22, 2010): 1–8. http://dx.doi.org/10.4061/2010/540786.

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Potential new targets for antimalarial chemotherapy include parasite proteases, which are required for several cellular functions during the Plasmodium falciparum life cycle. Four new derivatives of N-alkyl and N-benzyl-1,10-phenanthroline have been synthesized. Those are (1)-N-methyl-1,10-phenanthrolinium sulfate, (1)-N-ethyl-1,10-phenanthrolinium sulfate, (1)-N-benzyl-1,10-phenanthrolinium chloride, and (1)-N-benzyl-1,10-phenanthrolinium iodide. Those compounds had potential antiplasmodial activity with IC50 values from 260.42 to 465.38 nM. Cysteine proteinase inhibitor E64 was used to inves

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Rucins, Martins, Pavels Dimitrijevs, Klavs Pajuste, et al. "Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines." Pharmaceutics 11, no. 3 (2019): 115. http://dx.doi.org/10.3390/pharmaceutics11030115.

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The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising n

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Cablewski, Teresa, Craig L. Francis, and Andris J. Liepa. "N, N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. V The Preparation of some Benzimidazo-Fused [1,2,4,6]Thiatriazine Dioxides." Australian Journal of Chemistry 61, no. 1 (2008): 59. http://dx.doi.org/10.1071/ch07336.

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N,N-dialkyl-N′-chlorosulfonyl chloroformamidines 1 were treated with 2-aminobenzimidazoles 2 to give [1,2,4,6]thiatriazino[2,3-a]benzimidazole 1,1-dioxides 3 and [1,2,4,6]thiatriazino[4,3-a]benzimidazole 2,2-dioxides 4. Some N-alkyl-, N-acyl-, and N-sulfonyl-derivatives of 3 were prepared. These products are derivatives of rare heterocycles.

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34

Borovlev, Ivan, Oleg Demidov, Gulminat Amangasieva, and Elena Avakyan. "Nucleophilic Addition of Amides to 10-Alkylacridinium Cations: A Case of Double N-Nucleophilicity of Some Monoamides." Synthesis 49, no. 16 (2017): 3710–19. http://dx.doi.org/10.1055/s-0036-1588786.

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An effective synthesis of N-(10-alkyl-9,10-dihydroacridin-9-yl) derivatives of amides, ureas, and urethanes has been developed. Additionally, the spatially overloaded molecules of N,N-bis(10-alkyl-9,10-dihydroacridin-9-yl)acrylamide were obtained in the case of formamide and acrylamide.

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35

Walczewska, Agata, Daria Grzywacz, Dorota Bednarczyk та ін. "N-Alkyl derivatives of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside; synthesis and antimicrobial activity". Beilstein Journal of Organic Chemistry 11 (22 травня 2015): 869–74. http://dx.doi.org/10.3762/bjoc.11.97.

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Diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside is a synthetic saponin exhibiting attractive pharmacological properties. Different pathways tested by us to obtain this glycoside are summarized here. Moreover, the synthesis of N-alkyl and N,N-dialkyl derivatives of the glucopyranoside is presented. Evaluation of antibacterial and antifungal activities of these derivatives indicates that they have no inhibitory activity against Gram-negative bacteria, whereas many of the tested N-alkyl saponins were found to inhibit the growth of Gram-positive bacteria and human pathogenic fungi.

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36

Journal, Baghdad Science. "Synthesis and Characterization of 1,3,4-Oxadiazoles Derived From 9-Fluorenone." Baghdad Science Journal 10, no. 2 (2013): 449–61. http://dx.doi.org/10.21123/bsj.10.2.449-461.

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In the present work, 9-fluorenone-2-carboxylic acid methyl ester (1) was prepared from 9-fluorenone-2-carboxylic acid and then converted into the acid hydrazide (2). Compound (2), is the key intermediate for the synthesis of several series of new compounds such as substituted 1,3,4-oxadiazole derivatives (3-6) were synthesized from the condensation of different substituted benzoic acids with compound (2) using POCl3 as condensing agent. Treatment of compound (2) with formic acid gave the N-formyl hydrazide (7), which upon refluxing with phosphorous pentoxide in benzene yielded the correspondin

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37

Dawood, Rafid Saad. "Synthesis and Characterization of 1,3,4-Oxadiazoles Derived From 9-Fluorenone." Baghdad Science Journal 10, no. 2 (2013): 449–61. http://dx.doi.org/10.21123/bsj.2013.10.2.449-461.

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In the present work, 9-fluorenone-2-carboxylic acid methyl ester (1) was prepared from 9-fluorenone-2-carboxylic acid and then converted into the acid hydrazide (2). Compound (2), is the key intermediate for the synthesis of several series of new compounds such as substituted 1,3,4-oxadiazole derivatives (3-6) were synthesized from the condensation of different substituted benzoic acids with compound (2) using POCl3 as condensing agent. Treatment of compound (2) with formic acid gave the N-formyl hydrazide (7), which upon refluxing with phosphorous pentoxide in benzene yielded the correspondin

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38

Shiohara, Kei, Shigeki Habaue, and Yoshio Okamoto. "Asymmetric Anionic Polymerization of Alkyl-Substituted N,N-Diphenylacrylamide Derivatives." Polymer Journal 30, no. 3 (1998): 249–55. http://dx.doi.org/10.1295/polymj.30.249.

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Brătulescu, George. "ALKYL-1H-BENZO[D]IMIDAZOLE SYNTHESIS FROM ALKYL BROMIDES AND 1,2-BENZENEDIAMINES BY A MILD DOMINO REACTION." Annals of the University of Craiova, Series Chemistry 27, no. 2 (2021): 5–11. http://dx.doi.org/10.52846/auc.chem.2021.2.01.

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A method was implemented for synthesis of 2-alkyl-1H-benzo[d]imidazole derivatives in dry medium. Starting reagents, 1,2-diaminobenzene derivatives and primary alkyl halides using pyridine N-oxide is converted into benzimidazoles. The protocol does not use catalyst and solvent. Simplicity and easy work-up are the important advantages of the method.

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40

Brătulescu, George. "ALKYL-1H-BENZO[D]IMIDAZOLE SYNTHESIS FROM ALKYL BROMIDES AND 1,2-BENZENEDIAMINES BY A MILD DOMINO REACTION." Annals of the University of Craiova, Series Chemistry 27, no. 2 (2021): 5–11. http://dx.doi.org/10.52846/aucchem.2021.2.01.

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A method was implemented for synthesis of 2-alkyl-1H-benzo[d]imidazole derivatives in dry medium. Starting reagents, 1,2-diaminobenzene derivatives and primary alkyl halides using pyridine N-oxide is converted into benzimidazoles. The protocol does not use catalyst and solvent. Simplicity and easy work-up are the important advantages of the method.

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41

Kusukawa, Takahiro, Seiji Shibata, Fumihiro Kannen, and Kenji Yoza. "Mechnofluorochromic properties of N-alkyl amide anthracene derivatives." Tetrahedron 111 (April 2022): 132735. http://dx.doi.org/10.1016/j.tet.2022.132735.

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Monteiro, Luís S., Silvia M. M. A. Pereira-Lima, Sofia Pereira та João N. Machado. "Synthesis of N-alkyl-Cα,α-dimethylglycine derivatives". Arkivoc 2014, № 5 (2014): 170–80. http://dx.doi.org/10.3998/ark.5550190.p008.622.

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43

Sharma, Rajnish K., Malti Sharma, and Yashpal Singh. "Monoorganosilicon(IV) Complexes of 2-Aminocyclopentene-1-carbodithioic Acid and its N-/S-Alkyl Derivatives: Synthesis and Characterization." Asian Journal of Chemistry 33, no. 12 (2021): 3134–38. http://dx.doi.org/10.14233/ajchem.2021.23538.

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2-Aminocyclopentene-1-carbodithioic acid (ACDA) and its N-/S-alkyl derivatives of methylsilicon(IV) chloride have been synthesized by the reactions of MeSiCl3 with sodium salt of ACDA and its N-/S-alkyl derivatives in 1:1 and 1:2 molar ratios. All these complexes have been characterized by elemental analysis, molecular weight measurements and spectroscopic (IR, 1H and 13C NMR) studies. The central silicon atom is coordinated to two sulphur atoms or one sulphur atom and one nitrogen atom of the ligand moiety in all of these derivatives, resulting in five and six coordination.

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Durantel, David, Norica Branza-Nichita, Sandra Carrouée-Durantel, Terry D. Butters, Raymond A. Dwek, and Nicole Zitzmann. "Study of the Mechanism of Antiviral Action of Iminosugar Derivatives against Bovine Viral Diarrhea Virus." Journal of Virology 75, no. 19 (2001): 8987–98. http://dx.doi.org/10.1128/jvi.75.19.8987-8998.2001.

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ABSTRACT The glucose-derived iminosugar derivatives N-butyl- andN-nonyl-deoxynojirimycin (DNJ) have an antiviral effect against a broad spectrum of viruses including Bovine viral diarrhea virus (BVDV). For BVDV, this effect has been attributed to the reduction of viral secretion due to an impairment of viral morphogenesis caused by the ability of DNJ-based iminosugar derivatives to inhibit ER α-glucosidases (N. Zitzmann, A. S. Mehta, S. Carrouée, T. D. Butters, F. M. Platt, J. McCauley, B. S. Blumberg, R. A. Dwek, and T. M. Block, Proc. Natl. Acad. Sci. USA 96:11878–11882, 1999). Here we pres

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Zhao, Wannian, Ping Xie, Min Zhang, et al. "Synthesis of isoquinoline-1,3(2H,4H)-dione derivatives via cascade reactions of N-alkyl-N-methacryloyl benzamide with aryl aldehydes." Org. Biomol. Chem. 12, no. 39 (2014): 7690–93. http://dx.doi.org/10.1039/c4ob01442a.

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46

Žunec, Suzana, Donna Vadlja, Alma Ramić, et al. "Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability." International Journal of Molecular Sciences 25, no. 1 (2023): 155. http://dx.doi.org/10.3390/ijms25010155.

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The cholinergic system, relying on the neurotransmitter acetylcholine (ACh), plays a significant role in muscle contraction, cognition, and autonomic nervous system regulation. The enzymes acetylcholinesterase, AChE, and butyrylcholinesterase, BChE, responsible for hydrolyzing ACh, can fine-tune the cholinergic system’s activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. We designed, synthesized, and profiled 14 N-alkyl quaternary quinuclidines as inhibitors of human AChE and BChE and analyzed their impact on cell viability to assess their s

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Yang, Xiaobing, Yang Wang, Fangzhong Hu та ін. "Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles". RSC Advances 6, № 72 (2016): 68454–59. http://dx.doi.org/10.1039/c6ra14897b.

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Boyer, Gérard, Florence Chatel, Sandrine Morel, and Jean Pierre Galy. "Synthesis of New N-Alkyl- and N-Acyldioxinophenothiazine and Acridinone Derivatives." HETEROCYCLES 53, no. 11 (2000): 2535. http://dx.doi.org/10.3987/com-00-9013.

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Prusinowska, Natalia, Agnieszka Czapik, Martika Wojciechowska, and Marcin Kwit. "Dynamic optical activity induction in the N-alkyl-N′-trityl ureas and thioureas." Organic & Biomolecular Chemistry 17, no. 33 (2019): 7782–93. http://dx.doi.org/10.1039/c9ob01319a.

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50

Alam, Ryan M., and John J. Keating. "Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution." Beilstein Journal of Organic Chemistry 17 (August 2, 2021): 1939–51. http://dx.doi.org/10.3762/bjoc.17.127.

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The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient synthesis and isolation of the desired N-1 or N-2 alkylindazole regioisomer can often be challenging and adversely affect product yield. Thus, as part of a broader study focusing on the synthesis of bioactive indazole derivatives, we aimed to develop a regioselective protocol for the synthesis of N-1 alkylindazoles. Initial screening of various con

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