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Journal articles on the topic 'N-Benzyl benzylamines'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Neeraj, Rani, R. Sharma J., K. Kaul V., and R. Manrao M. "Secondary amines : Synthesis and effect of length of spacer linking two phenyl rings on biological activity." Journal of Indian Chemical Society Vol. 85, Oct 2008 (2008): 1041–44. https://doi.org/10.5281/zenodo.5820670.

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Department of Chemistry, Department of Plant Pathology, Punjab Agricultural University, Ludhiana-141 004, Punjab, India <em>Manuscript received 7 January 2008, revised 30 June 2008, accepted 16 July 2008</em> N-Benzyl benzylamines (1a-11a) and N-benzyl anilines (1b-11b) were synthesized by sodium borohydride reduction of aldimines of benzylamine and aniline respectively. The products were characterized on the basis of elemental analysis and spectral studies and screened for antifungal potential against four fungi and evaluated for nematicidal activity against two nematodes. The former compound

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2

Ramkumar, Nagarajan, and Rajagopal Nagarajan. "Formal total synthesis of calothrixin B and its N-benzyl analogues." RSC Advances 5, no. 107 (2015): 87838–40. http://dx.doi.org/10.1039/c5ra18120h.

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3

Galletti, P., G. Martelli, G. Prandini, C. Colucci, and D. Giacomini. "Sodium periodate/TEMPO as a selective and efficient system for amine oxidation." RSC Advances 8, no. 18 (2018): 9723–30. http://dx.doi.org/10.1039/c8ra01365a.

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4

Dama, Habila J., Kandappa H. Reddy, Patrick Govender, and Neil A. Koorbanally. "Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/281341.

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A series of eleven butanediamine analogues, of which nine were new, were synthesized by the nucleophilic substitution of aromatic amines and benzylamines with maleic anhydride and tested on four yeast strains ofCandidaspecies using the broth microdilution method. Compounds3aand3cwith an unsubstituted phenyl ring and a 3-methoxyphenyl ring, respectively, are the most active against the fungal species with MIC values ranging from 20.2 to 80.6 μM forC. albicansandC. parapsilosisand 178.5 and 161.2 μM forC. krusei, respectively.

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5

Rádl, Stanislav, Jan Stach, Josef Černý, and Ondřej Klecán. "An efficient synthesis of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine, a key intermediate in the licofelone synthesis." Collection of Czechoslovak Chemical Communications 74, no. 6 (2009): 1011–22. http://dx.doi.org/10.1135/cccc2009026.

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An efficient synthesis of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine, a key intermediate for the synthesis of licofelone, an anti-inflammatory drug currently undergoing evaluation of the phase-III clinical studies, is described. The method is based on a novel synthesis of unstable 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole, which is then treated with 2-bromo-1-(4-chlorophenyl)ethan-1-one. 2,2-Dimethyl-5-phenylpent-4-ynal with benzylamines provides the corresponding Schiff bases. Migration of the C=N double bond in these N-(2,2-dimethyl-5-phenylpent-4-yn-1-ylidene)ben

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6

Laha, Joydev K., Pankaj Gupta, and Amitava Hazra. "Sulfate radical anion-induced benzylic oxidation of N-(arylsulfonyl)benzylamines to N-arylsulfonylimines." Beilstein Journal of Organic Chemistry 19 (June 5, 2023): 771–77. http://dx.doi.org/10.3762/bjoc.19.57.

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A mild, operationally convenient, and practical method for the synthesis of synthetically useful N-arylsulfonylimines from N-(arylsulfonyl)benzylamines using K2S2O8 in the presence of pyridine as a base is reported herein. In addition, a “one-pot” tandem synthesis of pharmaceutically relevant N-heterocycles by the reaction of N-arylsulfonylimines, generated in situ with ortho-substituted anilines is also reported. The key features of the protocol include the use of a green oxidant, a short reaction time (30 min), chromatography-free isolation, scalability, and economical, delivering N-arylsulf

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7

Kim, Sung Soo, and Hwan Kyu Jung. "OxidativeN-debenzylation ofN-benzyl-N-substituted benzylamines catalyzed by horseradish peroxidase." Journal of Physical Organic Chemistry 16, no. 8 (2003): 555–58. http://dx.doi.org/10.1002/poc.648.

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8

Ulgen, Mert, and John W. Gorrod. "The Failure of Substrate pKa to Influence the Microsomal Formation of Amides from N-Benzylamines: the Microsomal Metabolism of N-Benzyl Pyrrolidine, N-Benzyl Carbazole and N-Acetyl-N-benzyl-4-methylaniline." Journal of Pharmacy and Pharmacology 48, no. 12 (1996): 1320–26. http://dx.doi.org/10.1111/j.2042-7158.1996.tb03943.x.

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9

Mlostoń, Grzegorz, Mateusz Kowalczyk, Małgorzata Celeda, Marcin Jasiński, Marta Denel-Bobrowska, and Agnieszka B. Olejniczak. "Fluorinated Analogues of Lepidilines A and C: Synthesis and Screening of Their Anticancer and Antiviral Activity." Molecules 27, no. 11 (2022): 3524. http://dx.doi.org/10.3390/molecules27113524.

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Starting with fluorinated benzylamines, a series of 2-unsubstituted imidazole N-oxides was prepared and subsequently deoxygenated in order to prepare the corresponding imidazoles. The latter were treated with benzyl halides yielding imidazolium salts, which are considered fluorinated analogues of naturally occurring imidazolium alkaloids known as lepidilines A and C. A second series of oxa-lepidiline analogues was obtained by O-benzylation of the initially synthetized imidazole N-oxides. Both series of imidazolium salts were tested as anticancer and antiviral agents. The obtained results demon

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10

Patel, Srilaxmi M., Harika Chada, Sonali Biswal, Sonika Sharma та Duddu S. Sharada. "Copper-Catalyzed Intramolecular α-C–H Amination via Ring-Opening Cyclization Strategy to Quinazolin-4-ones: Development and Application in Rutaecarpine Synthesis". Synthesis 51, № 16 (2019): 3160–70. http://dx.doi.org/10.1055/s-0037-1611575.

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A copper-catalyzed intramolecular α-C–H amination has been developed for the synthesis of quinazolin-4(3H)-one derivatives from commercially available isatoic anhydride and primary and secondary benzylamines via ring-opening cyclization (ROC). This method shows good functional group tolerance and allows access to a range of 2-aryl, 2-alkyl, and spiroquinazolinone derivatives. However, 2-methylquinazolin-4(3H)-one was synthesized from 2-amino-N-isopropylbenzamide by C–C bond cleavage, and N-benzyl-2-(methylamino)benzamide afforded 1-methyl-2-phenylquinazolin-4(1H)-one along with 2-phenylquinazo

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11

Kumar, Arvind, Pawan Kumar, Chetan Joshi, et al. "A [Fe(bpy)3]2+ grafted graphitic carbon nitride hybrid for visible light assisted oxidative coupling of benzylamines under mild reaction conditions." Green Chemistry 18, no. 8 (2016): 2514–21. http://dx.doi.org/10.1039/c5gc02090e.

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Iron(ii) bipyridine grafted on graphitic carbon nitride (Fe(bpy)<sub>3</sub>/npg-C<sub>3</sub>N<sub>4</sub>) was found to be an efficient photocatalyst for oxidative coupling of benzyl amines using molecular oxygen as an oxidant and a household white LED as a light emitting source.

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12

Vicker, Nigel, Helen V. Bailey, Joanna M. Day та ін. "Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3". Molecules 26, № 23 (2021): 7166. http://dx.doi.org/10.3390/molecules26237166.

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17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3) is expressed at high levels in testes and seminal vesicles; it is also present in prostate tissue and involved in gonadal and non-gonadal testosterone biosynthesis. The enzyme is membrane-bound, and a crystal structure is not yet available. Selective aryl benzylamine-based inhibitors were designed and synthesised as potential agents for prostate cancer therapeutics through structure-based design, using a previously built homology model with docking studies. Potent, selective, low nanomolar IC50 17β-HSD3 inhibitors were discovered using N-(2-([

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13

Zeng, Qingle, Fuhai Li, and Xianjie Yin. "Transition metal-catalyzed construction of C-X bonds via cleavage of C-N bond of quaternary ammonium salts." AIMS Molecular Science 10, no. 3 (2023): 153–70. http://dx.doi.org/10.3934/molsci.2023011.

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<abstract> <p>Amines are abundant in natural product chemistry and are readily available chemical raw materials. The C-N bonds of amines are difficult to break due to the large C-N bond energy. In recent years, chemists have developed a variety of activation methods for amino groups of amines. Among these reported methods, to convert amines into quaternary ammonium salts is preferred, for quaternary ammonium salts are readily available and stable. In recent years, great progress has been achieved in the study of transition metal-catalyzed construction of various C-X bonds involving

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14

Liu, Yongzhuang, Anastasiia Afanasenko, Saravanakumar Elangovan, Zhuohua Sun, and Katalin Barta. "Primary Benzylamines by Efficient N-Alkylation of Benzyl Alcohols Using Commercial Ni Catalysts and Easy-to-Handle Ammonia Sources." ACS Sustainable Chemistry & Engineering 7, no. 13 (2019): 11267–74. http://dx.doi.org/10.1021/acssuschemeng.9b00619.

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15

Liu, Yongzhuang, Anastasiia Afanasenko, Saravanakumar Elangovan, Zhuohua Sun, and Katalin Barta. "Primary Benzylamines by Efficient N-Alkylation of Benzyl Alcohols Using Commercial Ni Catalysts and Easy-to-Handle Ammonia Source." ACS Sustainable Chemistry & Engineering 7, no. 13 (2019): 11267–74. https://doi.org/10.5281/zenodo.10164388.

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16

Kroutil, Jiří, Jindřich Karban, Tomáš Trnka, Miloš Buděšínský та Miloslav Černý. "Preparation of O-, S- and N-Benzyl Derivatives of 1,6-Anhydro-β-D-hexopyranoses via Aziridine Ring Opening". Collection of Czechoslovak Chemical Communications 67, № 12 (2002): 1805–19. http://dx.doi.org/10.1135/cccc20021805.

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The aziridine ring opening of N-tosylepimino carbohydrates 1-6 having D-allo, D-manno, D-galacto and D-talo configurations with benzyl alcohol, benzylamine and phenylmethanethiol afforded 2-, 3- and 4-O-benzyl-, benzylsulfanyl and benzylamino derivatives of 1,6-anhydro-β-D-hexopyranoses of D-gluco, D-galacto and D-manno configurations 7-23 in 44-99% yields. Hexenopyranoses 24-26 were prepared from tosylepimino carbohydrates 1, 4 and 5 by intramolecular rearrangement of the aziridine ring.

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17

Gupta, Shyam Sunder R., Akhil V. Nakhate, Gunjan P. Deshmukh, et al. "Direct Synthesis of Amides from Oxidative Coupling of Benzyl Alcohols or Benzylamines with N -Substituted Formamides Using a Cu-Fe-Based Heterogeneous Catalyst." ChemistrySelect 3, no. 29 (2018): 8436–43. http://dx.doi.org/10.1002/slct.201801297.

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18

Belz, Tyson, Saleh Ihmaid, Jasim Al-Rawi, and Steve Petrovski. "Synthesis Characterization and Antibacterial, Antifungal Activity of N-(Benzyl Carbamoyl or Carbamothioyl)-2-hydroxy Substituted Benzamide and 2-Benzyl Amino-Substituted Benzoxazines." International Journal of Medicinal Chemistry 2013 (October 31, 2013): 1–20. http://dx.doi.org/10.1155/2013/436397.

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New N-(benzyl carbamothioyl)-2-hydroxy substituted benzamides 13, 20, and 21 were synthesized using sodium bicarbonate and benzyl amine with 2-thioxo-substituted-1,3-benzoxazines 6, 10a, b, 11c, and 12a–n. The 2-thioxo-substituted-1,3-oxazines 6, 10a-b, 11d 12a–n, and 26 were converted to the corresponding 2-methylthio-substituted-1,3-oxazines 14a–l and 24 which were then converted to 2-benzyl amino-substituted-benzoxazines 15a–i by refluxing with benzylamine. Products 15a, b, e, f, and g were also synthesized by boiling the corresponding N-(benzyl carbamothioyl)-2-hydroxy substituted benzamid

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19

SHUROV, S. N., T. N. YANBORISOV, YU S. ANDREICHIKOV, and Z. G. ALIEV. "ChemInform Abstract: Reactions of 5-Aryl-2-tosylmethylimino-2,3-dihydro-3-furanones with Substituted N-Benzylidene benzylamines. Crystal Structure of 1-Benzyl 5-(4-Methyloxyphenyl)-2-(4-chlorobenzoyl)acetyl Imidazole." ChemInform 27, no. 8 (2010): no. http://dx.doi.org/10.1002/chin.199608136.

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20

Shelp, Russell A., Anthony Ciro, Youge Pu, Rohan R. Merchant, Jonathan M. E. Hughes, and Patrick J. Walsh. "Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates." Chemical Science 12, no. 20 (2021): 7066–72. http://dx.doi.org/10.1039/d1sc01349a.

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21

Contreras-Espejel, Carlos Abraham, Marco A. García-Eleno, Ericka Santacruz-Juárez, Reyna Reyes-Martínez, and David Morales-Morales. "N-Benzyl-2-hydroxyethanaminium cyanurate." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (2013): o1741—o1742. http://dx.doi.org/10.1107/s1600536813029383.

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In the cation of the title compound C9H14ON+·C3H2O3N3−, the benzylamine C—N bond subtends a dihedral angle of 78.3 (2)° with the phenyl ring. The cyanurate anion is in the usual keto-form and shows an r.m.s. deviation from planarity of 0.010 Å. In the crystal, the cyanurate anions form N—H...O hydrogen-bonded zigzag ribbons along [001]. These ribbons are crosslinked by the organocationsviaO—H...N and N—H...O hydrogen bonds, forming bilayers parallel to (010) which are held together along [010] by slipped π–π interactions between pairs of cyanurate anions [shortest contact distances C...C = 3.4

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22

Blanco-Carapia, Roberto E., Enrique A. Aguilar-Rangel, Alejandro Islas-Jácome, and Eduardo González-Zamora. "Ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine)." Molbank 2022, no. 3 (2022): M1444. http://dx.doi.org/10.3390/m1444.

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The new bis-heterocyclic compound ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine) (1) was synthesized in 73% overall yield in 1.5 hours via a pseudo-repetitive Ugi-Zhu five-component reaction, starting from 1,1′-ferrocenedicarboxaldehyde, 4-(trifluoromethyl)benzylamine, and 2-isocyano-1-morpholino-3-phenylpropan-1-one, in 1:2.1:2.2 proportions, respectively, using scandium(III) triflate as a Lewis-acid catalyst, microwaves as a heat source, and toluene as a solvent. The synthesized compound was characterized by 1D (1H, 13C, and 19F) and 2D (COSY,

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23

Szabo, Jan, Julian Greiner, and Gerhard Maas. "Derivatives of the triaminoguanidinium ion, 5. Acylation of triaminoguanidines leading to symmetrical tris(acylamino)guanidines and mesoionic 1,2,4-triazolium-3-aminides." Beilstein Journal of Organic Chemistry 13 (March 22, 2017): 579–88. http://dx.doi.org/10.3762/bjoc.13.57.

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Depending on the reaction conditions, N,N’,N’’-tris(benzylamino)guanidinium salts can react with carboxylic acid chlorides to form either symmetrical N,N’,N’’-tris(N-acyl-N-benzylamido)guanidines 6 or mesoionic 4-amino-1,2,4-triazolium-3-hydrazinides 7. The latter were converted into 1,2,4-triazolium salts by protonation or methylation at the hydrazinide nitrogen atom. Neutral 1,2,4-triazoles 10 were obtained by catalytic hydrogenation of an N-benzyl derivative. Crystal structure analyses of a 4-benzylamino-1,2,4-triazolium-3-hydrazinide and of two derived 1,2,4-triazolium salts are presented.

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24

Ryan, John H., Nadia Spiccia, Leon S. M. Wong, and Andrew B. Holmes. "Synthesis of 5-Aryloxazolidines via 1,3-Dipolar Cycloaddition Reaction of a Non-Stabilized Azomethine Ylide with Aromatic Aldehydes." Australian Journal of Chemistry 60, no. 12 (2007): 898. http://dx.doi.org/10.1071/ch07282.

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The 1,3-dipolar cycloaddition reaction of a non-stabilized azomethine ylide 4a, formed in situ from N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine 5 and a catalytic amount of trifluoroacetic acid, with aromatic aldehydes 3 gives rise to N-benzyl-5-aryloxazolidines 1. Under these conditions, 4-hydroxybenzaldehyde 3p undergoes two-fold addition of azomethine ylide 4a to afford bis adduct 11.

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25

Ciber, Luka, Helena Brodnik, Franc Požgan, Jurij Svete, Bogdan Štefane, and Uroš Grošelj. "Synthesis of N1-(3,5-Bis(trifluoromethyl)benzyl)benzene-1,2-diamine and N,N-Bis(2-nitrophenyl)-3,5-bis(trifluoromethyl)aniline." Molbank 2023, no. 3 (2023): M1718. http://dx.doi.org/10.3390/m1718.

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A monosubstituted benzene-1,2-diamine building block, N1-(3,5-bis(trifluoromethyl)benzyl)benzene-1,2-diamine, was prepared in two steps from commercially available 3,5-bis(trifluoromethyl)benzylamine and 1-fluoro-2-nitrobenzene, while the use of 3,5-bis(trifluoromethyl)aniline as the starting amine gave a triarylamine, N,N-bis(2-nitrophenyl)-3,5-bis(trifluoromethyl)aniline. The structures of the newly synthesized compounds were fully characterized.

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26

Maslivetc, Vladimir, Colby Barrett, Nicolai A. Aksenov, Marina Rubina, and Michael Rubin. "Intramolecular nucleophilic addition of carbanions generated from N-benzylamides to cyclopropenes." Organic & Biomolecular Chemistry 16, no. 2 (2018): 285–94. http://dx.doi.org/10.1039/c7ob02068f.

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An unusual reaction is described, involving a formal intramolecular nucleophilic substitution of bromocyclopropanes with nitrogen ylides generated in situ from N-benzyl carboxamides. This reaction involves cyclopropene intermediates and allows for the facile preparation of 3-azabicyclo[3.1.0]hexan-2-ones.

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27

Vasuki, B., N. Mahadevan, V. Sekar, M. Vijayabaskaran, and V. Senthil. "Synthesis and cytotoxicity of Mannich Base of Benzimidazole Derivatives against Neuroblastoma Cell line." Research Journal of Chemistry and Environment 27, no. 4 (2023): 113–19. http://dx.doi.org/10.25303/2704rjce1130119.

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The present study is to synthesize a novel Mannich base of benzimidazole derivatives and to screen for cytotoxicity in a neuroblastoma cell line using the MTT assay. 2-phenyl benzimidazole, formaldehyde, adamantine 1-carboxylicacid and substituted benzylamine such as 4-methyl, 4-methoxy, 4-chloro, 2-chloro, 4-fluoro, 3-methoxy, 4-trifluoromethyl, 3,4-dichloro and 3,5 bistrifluoromethyl were used to synthesize Mannich bases of (3r, 5r, 7r)-N-Benzyl-N-((2-phenyl-1H-benzo[d]imidazol-1-yl) methyl) adamantane-1-carboxamide. The MTT cell viability assay was performed to determine the half maximal in

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28

Holzgrabe, U., B. Piening, K. F. Hesse, H. D. Höltje, and M. Worch. "Stereochemistry of 2,6-Dipyridine Substituted N-Benzyl-4-piperidone Mono- and Dicarboxylates and of the Corresponding Reduction Products." Zeitschrift für Naturforschung B 44, no. 5 (1989): 565–74. http://dx.doi.org/10.1515/znb-1989-0512.

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The alkyl N-benzyl-4-piperidone-3-carboxylate (1) is synthesized by a Mannich procedure from pyridine aldehyde, benzylamine and the monoester of acetonedicarboxylate; the corresponding diester 2 is formed by condensation of pyridine aldehyde, benzylamine and dimethyl 3-oxoglutarate. Isomerism is observed with respect to keto-enol tautomerism and cis or trans substitution of the pyridines. The structure of the enol lb (C24H23N3O3) is determined by X-ray analysis: it crystallizes in the triclinic space group P 1̄ with a = 9.965(2), b = 10.476(2), c = 10.838(2) Å, α = 69.48(1), β/3 = 81.56(1), γ

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29

Krchňák, Viktor, Jennifer Smith, and Josef Vágner. "Solid-Phase Traceless Synthesis of Selected Nitrogen-Containing Heterocyclic Compounds. The Encore Technique for Directed Sorting of Modular Solid Support." Collection of Czechoslovak Chemical Communications 66, no. 7 (2001): 1078–106. http://dx.doi.org/10.1135/cccc20011078.

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The acid lability of electron-rich N-benzylanilines has been exploited in a linker for the traceless solid-phase synthesis of benzimidazoles, 2-aminobenzimidazoles, quinoxalinones and tetrahydroquinoxalines. The target compound precursors were assembled on a solid-phase support derivatized with either a benzylamine or a benzhydrylamine linker. Exposure to an acidic reagent caused cleavage of the C(benzyl)-N(aniline) bond, releasing the product with only a hydrogen atom on the descending nitrogen. The Encore technique for directed sorting on SynPhase Lanterns has been developed and applied to c

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30

Sonawane, R. S., Mrunal Shirsat, S. R. Patil, J. C. Hundiwale, and A. V. P. atil. "Design and Synthesis of Novel Imidazopyridine Analogues and Evaluation as H+/K+-ATPase Antagonist." Asian Journal of Chemistry 32, no. 11 (2020): 2685–92. http://dx.doi.org/10.14233/ajchem.2020.22697.

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CID data base were explored considering AZD0865 as standard and docked in proton pump ATPase pocket (PDB ID: 4ux2) to find out novel imidazopyridine derivatives as proton pump inhibitors. A number of compounds showed good proton pump ATPase inhibitory activity as per the molecular docking study as compared to standard compound AZD0865. The compound AZD0865showed a docking score of -7.11 and revealed the interactions with amino acids Asn 138 and Asp 137. A series of novel imidazopyridine derivatives as proton pump inhibitors were docked, synthesized and characterized by IR, NMR, CHN and MS spec

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31

Salinas-Torres, Angélica, Hugo Rojas, José J. Martínez, Diana Becerra, and Juan-Carlos Castillo. "Synthesis, Characterization, and DFT Studies of N-(3,5-Bis(trifluoromethyl)benzyl)stearamide." Molbank 2021, no. 2 (2021): M1215. http://dx.doi.org/10.3390/m1215.

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The novel N-(3,5-bis(trifluoromethyl)benzyl)stearamide 3 was prepared in moderate yield by a solventless direct amidation reaction of stearic acid 1 with 3,5-bis(trifluoromethyl)benzylamine 2 at 140 °C for 24 h under metal- and catalyst-free conditions. This practical method was conducted in air without any special treatment or activation. The fatty acid amide 3 was fully characterized by IR, UV–Vis, 1D and 2D NMR spectroscopy, mass spectrometry, and elemental analysis. Moreover, molecular electrostatic potential studies, determination of quantum descriptors, fundamental vibrational frequencie

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32

Ohki, Shinpei, Hideomi Takahashi, Nobuhiro Kuboyama, et al. "Photosynthetic Electron Transport Inhibition by Pyrimidines and Pyridines Substituted with Benzylamino, Methyl and Trifluoromethyl Groups." Zeitschrift für Naturforschung C 56, no. 3-4 (2001): 203–10. http://dx.doi.org/10.1515/znc-2001-3-406.

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AbstractThe decrease of the number of ring nitrogen atoms of 2-benzylamino-4-methyl-6-trifluoro-methyl-1,3,5-triazines on herbicidal activity and inhibition of photosynthetic electron trans port (PET) was assayed using thylakoids from Spinacia oleracea or atrazine-resistant Chenopodium album. Three 2-benzylamino-4-methyl-6-trifluoromethyl-1,3,5-triazines, nine pyrimidines with a benzylamino-, methyl-and trifluoromethyl-group, 2-benzylamino-6-methyl-4-trifluoromethyl-pyridine and N-benzyl-3-methyl-5-trifluoromethylaniline were synthesized and assayed. 2-(4-Bromobenzylamino)-4-methyl-6-trifluor

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33

Peterson, Matt, Adam Bowman, and Sarah Morgan. "EFFICIENT PREPARATION OF N-BENZYL SECONDARY AMINES VIA BENZYLAMINE?BORANE MEDIATED REDUCTIVE AMINATION." Synthetic Communications 32, no. 3 (2002): 443–48. http://dx.doi.org/10.1081/scc-120002129.

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34

Ganguly, Nemai C., and Mrityunjoy Datta. "Mild and Eco-friendly oXidative Cleavage of 1,3-dithianes and 1,3-dithiolanes with a Catalytic Amount of Hydrobromic Acid and Hydrogen Peroxide: Synergetic Effect of Bromonium Ion Equivalent and Hydrogen Peroxide." Journal of Chemical Research 2005, no. 4 (2005): 218–21. http://dx.doi.org/10.3184/0308234054213555.

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A combination of a catalytic amount hydrobromic acid (10 mol%) and an excess of hydrogen peroxide is found to be an effective reagent for expeditious regeneration of carbonyl compounds from their 1,3-dithiane as well as 1,3–dithiolane derivatives. Absence of nuclear bromination of aromatic substrates and overoxidation of regenerated oxidation–prone aromatic aldehydes, compatibility with a number of functional groups, such as amino, hydroxy, acetoxy, methylenedioxy and useful phenol-protecting allyl, benzyl and TBDMS ethers, benzoate esters and amino-protecting Cbz carbamate and N-benzylamine (

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Liu, Yu-Fen, Hai-Tao Xia, Da-Qi Wang та Shu-Ping Yang. "μ-Chlorido-bis({N-benzyl-N′-[2-(benzylamino)ethyl]ethane-1,2-diamine}chloridocopper(II)) chloride". Acta Crystallographica Section E Structure Reports Online 63, № 11 (2007): m2805—m2806. http://dx.doi.org/10.1107/s1600536807051434.

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In the title compound, [Cu2Cl3(C18H25N3)2]Cl, the asymmetric unit consists of one half of a μ-chlorido-bis[{N-benzyl-N′-[2-(benzylamino)ethyl]ethane-1,2-diamine}chloridocopper(II)] complex cation and one chloride anion lying on a twofold rotation axis. The two CuII centres are symmetry-related by a twofold rotation axis passing through the bridging Cl atom. The Cu atoms exhibit a distorted square-pyramidal coordination environment. The basal and apical Cu—Cl bond lengths are 2.254 (2) and 2.658 (2) Å, respectively. The Cu...Cu distance and Cu—Cl—Cu angle are 4.349 (6) Å and 109.8 (2)°, respect

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Moshkin, Vladimir S., Evgeniya V. Gorbunova, Evgeny M. Buev, and Vyacheslav Y. Sosnovskikh. "Three Ways Aliphatic Aldehydes React with Nonstabilized Azomethine Ylides." Synlett 31, no. 04 (2020): 343–48. http://dx.doi.org/10.1055/s-0039-1691562.

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Aliphatic aldehydes readily react with nonstabilized azomethine ylides in one of the three ways to give oxazolidines, pyrrolidines, or Mannich bases, depending on the structure of the starting compound and the reaction conditions. The use of N-(methoxymethyl)-N-[(trimethylsilyl)methyl]benzylamine in DMF provided 5-alkyloxazolidines in 40–97% yields. On the other hand, three-component reactions of aliphatic aldehydes bearing one α-hydrogen with N-methyl(benzyl)glycine and formaldehyde gives Mannich bases in yields of 47–98%. A similar reaction of aldehydes bearing branched alkyl groups and two

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MITSUI, Seiko, Kiyotaka MARUMO, Sumie ANDO-INOUE, Hideo KATO, and Yosiro SATO. "Heteroatom-Facilitated Lithiations of N-Methyl-N-(trimethylsilyl)methyl- benzylamine and Benzyl (Trimethylsilyl)methyl Ether with Butyllithium." CHEMICAL & PHARMACEUTICAL BULLETIN 41, no. 12 (1993): 2195–96. http://dx.doi.org/10.1248/cpb.41.2195.

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Jiao, Mengya, Qun Dong, Yiting Zhang, et al. "Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury." Molecules 26, no. 11 (2021): 3108. http://dx.doi.org/10.3390/molecules26113108.

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Maca (Lepidium meyenii) has emerged as a popular functional plant food because of its medicinal properties and nutritional value. Macamides, as the exclusively active ingredients found in maca, are a unique series of non-polar, long-chain fatty acid N-benzylamides with multiple bioactivities such as antifatigue characteristics and improving reproductive health. In this study, a new kind of macamide, N-benzyl eicosapentaenamide (NB-EPA), was identified from maca. We further explore its potential neuroprotective role in hypoxic–ischemic brain injury. Our findings indicated that treatment with bi

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Pretorius, Marié, D. Bradley G. Williams, Andreas Roodt та Alfred Muller. "Dichloro({N-[2-(diphenylphosphino-κP)benzyl]benzylamino}diphenylphosphine-κP)palladium(II) toluene solvate". Acta Crystallographica Section E Structure Reports Online 60, № 10 (2004): m1439—m1441. http://dx.doi.org/10.1107/s1600536804022214.

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SAKO, MAGOICHI, YUTAKA KOJIMA, KOSAKU HIROTA, and YOSHIFUMI MAKI. "Reactions of 6-(N-methylanilino)-5-(N-phenylimino)pyrimidine-2,4(3H,5H)-dione with benzyl hydrosulfide and benzylamine." CHEMICAL & PHARMACEUTICAL BULLETIN 33, no. 6 (1985): 2525–28. http://dx.doi.org/10.1248/cpb.33.2525.

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Peterson, Matt A., Adam Bowman, and Sarah Morgan. "ChemInform Abstract: Efficient Preparation of N-Benzyl Secondary Amines via Benzylamine-Borane Mediated Reductive Amination." ChemInform 33, no. 26 (2010): no. http://dx.doi.org/10.1002/chin.200226098.

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Moustafa, Reem, Attila Márió Remete, Zsolt Szakonyi, Nikoletta Szemerédi, Gabriella Spengler, and Tam Minh Le. "Synthesis and Antimicrobial Evaluation of (+)-Neoisopulegol-Based Amino and Thiol Adducts." International Journal of Molecular Sciences 26, no. 10 (2025): 4791. https://doi.org/10.3390/ijms26104791.

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A library of neoisopulegol-based amino and thiol adducts was developed from (+)-neoisopulegol, derived from commercially available (−)-isopulegol. Michael addition of different nucleophiles towards its highly active α,β-unsaturated γ-lactone motif was accomplished, resulting in diverse amino and thiol analogs in stereoselective reactions. Then, the lactone ring was opened, with NH3 and benzylamine furnishing primary amide and N-benzyl-substituted amide derivatives, respectively. The in vitro antimicrobial effect of prepared compounds was also explored. The results revealed that naphthylmethyl-

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Tyukhteneva, Z. I., and L. A. Badovskaya. "Lactonization of N-Benzyl-3-benzylamino-4-hydroxybutyramide under the Hofmann-Loffler Reaction Conditions." Russian Journal of Organic Chemistry 41, no. 6 (2005): 937. http://dx.doi.org/10.1007/s11178-005-0270-3.

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Nagalakshmi, R. A., J. Suresh, S. Maharani, R. Ranjith Kumar, and P. L. Nilantha Lakshman. "Crystal structure of 2-benzylamino-4-(4-bromophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile." Acta Crystallographica Section E Crystallographic Communications 71, no. 3 (2015): 296–98. http://dx.doi.org/10.1107/s2056989015002820.

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In the title compound C22H18BrN3, the cyclopentane ring adopts an envelope conformation with the central methylene C atom as the flap. The dihedral angles between the central pyridine ring and the pendant benzyl and and bromobenzene rings are 82.65 (1) and 47.23 (1)°, respectively. In the crystal, inversion dimers linked by pairs of N—H...Nn(n = nitrile) hydrogen bonds generateR22(12) loops. These dimers are linked by weak π–π interactions [centroid–centroid distance = 3.7713 (14) Å] into a layered structure.

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Hess, David, and Peter Mayer. "The crystal structures of benzylammonium phenylacetate and its hydrate." Acta Crystallographica Section E Crystallographic Communications 75, no. 2 (2019): 194–201. http://dx.doi.org/10.1107/s2056989019000288.

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The title compounds benzylammonium phenylacetate, C7H10N+·C8H7O2 − (1), and its monohydrate, C7H10N+·C8H7O2 −·H2O (2), can be obtained by evaporating methanolic solutions containing equimolar amounts of benzylamine and phenylacetic acid in the absence and presence of water, respectively. N—H...O hydrogen bonds in the crystal structure of 1 lead to the formation of hydrophilic channels running along the b-axis direction. The hydrogen-bonding system is best described by fused R 3 4(10) ring patterns, often observed in ammonium carboxylate salts. In 2, the presence of the crystal water leads to t

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Podda, Enrico, Massimiliano Arca, Giulia Atzeni, et al. "Antibacterial Activity of Amidodithiophosphonato Nickel(II) Complexes: An Experimental and Theoretical Approach." Molecules 25, no. 9 (2020): 2052. http://dx.doi.org/10.3390/molecules25092052.

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The reactions of 2,4-bis(4-methoxyphenyl)-1,3-dithio-2,4-diphosphetane-2,4-disulfide (Lawesson’s Reagent, LR) with benzylamine (BzNH2) and 4-phenylbutylamine (PhBuNH2) yield benzylammonium P-(4-methoxyphenyl)-N-benzyl-amidodithiophosphonate (BzNH3)(BzNH-adtp) and 4-phenylbutylammonium P-(4-methoxyphenyl)-N-(4-phenylbutyl)-amidodithiophosphonate (PhBuNH3)(PhBuNH-adtp). The relevant nickel complexes [Ni(BzNH-adtp)2] and [Ni(PhBuNH-adtp)2] and the corresponding hydrolysed derivatives (BzNH3)2[Ni(dtp)2] and (PhBuNH3)2[Ni(dtp)2] were prepared and fully characterized. The antimicrobial activity of t

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Asressu, Kesatebrhan Haile, Jeffery L. Smith, Rebekah J. Dickmander, et al. "Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity." Pharmaceuticals 17, no. 3 (2024): 306. http://dx.doi.org/10.3390/ph17030306.

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A series of 5-benzylamine-substituted pyrimido[4,5-c]quinoline derivatives of the CSNK2A chemical probe SGC-CK2-2 were synthesized with the goal of improving kinase inhibitor cellular potency and antiviral phenotypic activity while maintaining aqueous solubility. Among the range of analogs, those bearing electron-withdrawing (4c and 4g) or donating (4f) substituents on the benzyl ring as well as introduction of non-aromatic groups such as the cyclohexylmethyl (4t) were shown to maintain CSNK2A activity. The CSNK2A activity was also retained with N-methylation of SGC-CK2-2, but α-methyl substit

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Langlois, Nicole, and Olivier Calvez. "A Short and Efficient Synthesis of (3S,4S)-1-Benzyl-4-N-Benzylamino-3-Hydroxypiperidine." Synthetic Communications 28, no. 23 (1998): 4471–77. http://dx.doi.org/10.1080/00397919808004482.

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Tlekhusezh, M. A., Yu S. Andreichikov, Z. I. Tyukhteneva, and L. A. Badovskaya. "Reaction of N-benzyl-3-benzylamino-4-hydroxybutanamide with 5-phenyl-2,3-dihydrofuran-2,3-dione." Chemistry of Heterocyclic Compounds 34, no. 10 (1998): 1210–11. http://dx.doi.org/10.1007/bf02319505.

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Al-Azmi, Amal. "Novel 6-substituted Pyrimidines and Pyrimido[5,4-d]pyrimidines from (2-acetamido-1,2-dicyanovinyl)Ammonium Chloride." Journal of Chemical Research 2005, no. 8 (2005): 530–34. http://dx.doi.org/10.3184/030823405774663200.

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The reaction of triethyl orthoformate with 5-amino-6-ethoxy-2-methyl-4-pyrimidinecarbonitrile (5), available from DAMN via the ammonium salt 4, afforded iminoformate 6. The latter cyclised with aqueous ammonia or equimolar amounts of aryl/benzyl amines to give the corresponding pyrimido[5,4-d]pyrimidines 8, 9a–c. Reaction with excess of aqueous ethylamine, methylamine or benzylamine caused cyclisation with substitution of an ethoxy group to give 9d–f. Hydrolysis of compounds 8, 9a–b under acidic conditions gave the corresponding pyrimido[5,4-d]pyrimidones 10, 11a–b. Heating 4 to reflux in THF

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