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Journal articles on the topic 'N-chlorotaurine'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Nagl, Markus, Andreas Gruber, Anita Fuchs, et al. "Impact of N-Chlorotaurine on Viability and Production of Secreted Aspartyl Proteinases of Candida spp." Antimicrobial Agents and Chemotherapy 46, no. 6 (2002): 1996–99. http://dx.doi.org/10.1128/aac.46.6.1996-1999.2002.

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ABSTRACT N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.

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2

Kuzminykh, S. S., and O. V. Makarenko. "Pharmacoeconomic Analysis of N-Chlorotaurine Infusion Therapy in the Treatment of Patients with Peritonitis." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 5 (2022): 114–18. http://dx.doi.org/10.26693/jmbs07.05.114.

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Peritonitis is the main cause of death in patients with acute surgical diseases of the abdominal cavity. The average mortality rate from disseminated forms is currently 30%. In complications of multiple organ failure and infectious-toxic shock, as well as in postoperative peritonitis in elderly patients, the lethality rate can reach 40%–70%. Thus, this disease is one of the most pressing medical, biological and economic problems of our time. The purpose of the study was to perform pharmacoeconomic analysis of peritonitis treatment by medical technology using N-chlorotaurine in comparison with

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3

Nagl, Markus, Michael W. Hess, Kristian Pfaller, Paul Hengster, and Waldemar Gottardi. "Bactericidal Activity of MicromolarN-Chlorotaurine: Evidence for Its Antimicrobial Function in the Human Defense System." Antimicrobial Agents and Chemotherapy 44, no. 9 (2000): 2507–13. http://dx.doi.org/10.1128/aac.44.9.2507-2513.2000.

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ABSTRACT N-Chlorotaurine, the main representative of long-lived oxidants found in the supernatant of stimulated granulocytes, has been investigated systematically with regard to its antibacterial activity at different physiological concentrations for the first time.N-Chlorotaurine (12.5 to 50 μM) demonstrated a bactericidal effect i.e., a 2 to 4 log10 reduction in viable counts, after incubation at 37°C for 6 to 9 h at pH 7.0, which effect was significantly enhanced in an acidic milieu (at pH 5.0), with a 3 to 4 log10 reduction after 2 to 3 h. Moreover, bacteria were attenuated after being inc

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4

Kowalczyk, Kacper, Débora C. Coraça-Huber, Walter Wille-Kollmar, Michael Berktold, and Markus Nagl. "Activity of N-Chlorotaurine against Periodontal Pathogens." International Journal of Molecular Sciences 25, no. 15 (2024): 8357. http://dx.doi.org/10.3390/ijms25158357.

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Dental plaque bacteria play an important role in the pathogenicity of periodontitis and peri-implantitis. Therefore, antimicrobial agents are one means of treatment. N-chlorotaurine (NCT) as an endogenous well-tolerated topical antiseptic could be of advantage for this purpose. Accordingly, its microbicidal activity against some dental plaque bacteria was investigated at therapeutic concentrations in vitro. In quantitative killing assays, the activity of NCT against planktonic bacteria and against biofilms grown for 48 h on implantation screws was tested. Electron microscopy was used to demons

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5

Neher, Andreas, Markus Nagl, Anneliese Schrott-Fischer, et al. "N-Chlorotaurine, a Novel Endogenous Antimicrobial Agent." Archives of Otolaryngology–Head & Neck Surgery 127, no. 5 (2001): 530. http://dx.doi.org/10.1001/archotol.127.5.530.

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6

Fürnkranz, Ursula, Markus Nagl, Waldemar Gottardi, Martina Köhsler, Horst Aspöck, and Julia Walochnik. "Cytotoxic Activity of N-Chlorotaurine on Acanthamoeba spp." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 470–76. http://dx.doi.org/10.1128/aac.00715-07.

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ABSTRACT Acanthamoeba spp. are the causative agents of Acanthamoeba keratitis (AK), which mainly occurs in contact lens wearers, and of skin lesions, granulomatous amoebic encephalitis (GAE), and disseminating diseases in the immunocompromised host. AK therapy is complex and irritating for the eye, skin lesions are difficult to treat, and there is no effective treatment for GAE. Therefore, new anti-Acanthamoeba drugs are needed. We investigated the anti-Acanthamoeba activity of N-chlorotaurine (NCT), an endogenous mild antiseptic. It was shown that NCT has amoebicidal qualities, both in phosph

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7

Gottardi, W., and M. Nagl. "N-chlorotaurine, a natural antiseptic with outstanding tolerability." Journal of Antimicrobial Chemotherapy 65, no. 3 (2010): 399–409. http://dx.doi.org/10.1093/jac/dkp466.

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8

Liu, Zheng-Xian, and Irwin Fridovich. "Negative chemotaxis in Cytophaga johnsonae." Canadian Journal of Microbiology 42, no. 5 (1996): 515–18. http://dx.doi.org/10.1139/m96-069.

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Chemotaxis, both positive and negative, has been extensively studied in flagellated bacteria, such as Escherichia coli and Salmonella typhimurium, but not in gliding bacteria. The rapidly motile gliding bacterium Cytophaga johnsonae has been seen to be repelled by H2O2, OCl−, and N-chlorotaurine, as well as by low pH. Its response to H2O2 was eliminated by catalase. Nalidixic acid at 200 μM, which inhibits the growth but not the motility of C. johnsonae, did not interfere with its negative chemotactic response to H2O2, whereas sodium phosphate at 10 mM, which inhibits motility, did so. Cytopha

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9

Kusminyh, S. S., O. V. Ishchenko, I. Yu Stetsenko, G. I. Titov, and O. V. Makarenko. "MICROBIOLOGICAL REASONING OF N-CHLOROTAURINE USE IN SECONDARY PERITONITIS." Bulletin of Problems Biology and Medicine 2, no. 1 (2021): 184. http://dx.doi.org/10.29254/2077-4214-2021-2-160-184-188.

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10

Huber, Johann, Petra Winter, Waldemar Gottardi, Sabine Scholl-Bürgi, Wolfgang Prokop, and Markus Nagl. "Tolerability of N-chlorotaurine in the bovine mammary gland." Journal of Dairy Research 75, no. 2 (2008): 248–56. http://dx.doi.org/10.1017/s0022029908003233.

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N-Chlorotaurine (NCT) is a promising endogenous agent for topical treatment of infections. We tested the tolerability and pharmakokinetics of NCT in the bovine mammary glands in a phase 1 study. Three concentrations of NCT in water (0·1%, 1·0%, 2·0%) were administered intramammarily in each of two cows. Into two quarters of the udder 100 ml NCT was injected into each twice daily for 5 d, while 0·9% NaCl was injected into the other two quarters in a randomized and blinded manner. Samples of milk were taken to determine the number of leucocytes and the activity of NCT, and samples of urine and b

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11

Nagl, Markus, Clara Larcher, and Waldemar Gottardi. "Activity of N-chlorotaurine against herpes simplex- and adenoviruses." Antiviral Research 38, no. 1 (1998): 25–30. http://dx.doi.org/10.1016/s0166-3542(98)00005-9.

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12

Nagl, M. "Enhanced fungicidal activity of N-chlorotaurine in nasal secretion." Journal of Antimicrobial Chemotherapy 47, no. 6 (2001): 871–74. http://dx.doi.org/10.1093/jac/47.6.871.

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13

Neher, Andreas, Michaela Gstöttner, Markus Nagl, Arne Scholtz, and Andreas R. Gunkel. "N-chlorotaurine—A new safe substance for postoperative ear care." Auris Nasus Larynx 34, no. 1 (2007): 19–22. http://dx.doi.org/10.1016/j.anl.2006.09.001.

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14

Neher, Andreas, Roland Arnitz, Michaela Gstöttner, Dirk Schäfer, Eva-Maria Kröss, and Markus Nagl. "Antimicrobial Activity of Dexamethasone and Its Combination With N-Chlorotaurine." Archives of Otolaryngology–Head & Neck Surgery 134, no. 6 (2008): 615. http://dx.doi.org/10.1001/archotol.134.6.615.

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15

Murashevych, Bohdan, Gennadii Bilenkyi, Dmitry Girenko, and Emil Bilenkyi. "N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies." International Journal of Molecular Sciences 25, no. 15 (2024): 8345. http://dx.doi.org/10.3390/ijms25158345.

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N-chlorotaurine (NCT) is a broad-spectrum antimicrobial agent with outstanding tolerability, effective for topical and inhalation use. This paper presents the results of studies of single and repeated intravenous infusions of NCT to laboratory animals. The studies were conducted on female Wistar Han rats. The effect of NCT infusions on the general condition, behavioral reactions, main biochemical and hematological parameters, hemocoagulation system, cardiovascular system, and on the condition of the internal organs was studied. It was found that NCT infusions do not reveal deviations in the st

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16

Neher, Andreas, Hannes Fischer, Elisabeth Appenroth, et al. "Tolerability of N-chlorotaurine in chronic rhinosinusitis applied via yamik catheter." Auris Nasus Larynx 32, no. 4 (2005): 359–64. http://dx.doi.org/10.1016/j.anl.2005.05.006.

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17

Sheehan, Gerard, Markus Nagl, and Kevin Kavanagh. "Exposure to N-chlorotaurine induces oxidative stress responses in Aspergillus fumigatus." Journal of Medical Microbiology 68, no. 2 (2019): 279–88. http://dx.doi.org/10.1099/jmm.0.000900.

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18

Grimus, Victoria, Débora C. Coraça-Huber, Stephan J. M. Steixner, and Markus Nagl. "Activity of N-Chlorotaurine against Long-Term Biofilms of Bacteria and Yeasts." Antibiotics 10, no. 8 (2021): 891. http://dx.doi.org/10.3390/antibiotics10080891.

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Background: N-chlorotaurine (NCT), an antiseptic that originates from the human defense system, has broad-spectrum microbicidal activity and is well tolerated by human tissue and applicable to sensitive body regions. Bacteria in short-term biofilms, too, have been shown to be killed by NCT. It was the aim of the present study to demonstrate the activity of NCT against bacteria and yeasts in longer-lasting biofilms, including their co-culture. Materials and methods: Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella variicola biofilms were grown for 14 weeks in MBECTM inoculator with

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19

Antelo, Juan M., Florencio Arce, Paula Calvo, Juan Crugeiras, and Ana Ríos. "General acid–base catalysis in the reversible disproportionation reaction of N-chlorotaurine." Journal of the Chemical Society, Perkin Transactions 2, no. 10 (2000): 2109–14. http://dx.doi.org/10.1039/b003929m.

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20

Lorenz, K., D. Mayer, G. Bruhn, et al. "Effect of N-chlorotaurine mouth rinses on plaque regrowth and plaque vitality." Clinical Oral Investigations 13, no. 1 (2008): 9–14. http://dx.doi.org/10.1007/s00784-008-0207-7.

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21

Gottardi, Waldemar, Roland Arnitz, and Markus Nagl. "N-Chlorotaurine and ammonium chloride: An antiseptic preparation with strong bactericidal activity." International Journal of Pharmaceutics 335, no. 1-2 (2007): 32–40. http://dx.doi.org/10.1016/j.ijpharm.2006.11.003.

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22

Bellmann-Weiler, Rosa, Viola Maass, Roland Arnitz, Günter Weiss, Matthias Maass, and Markus Nagl. "The endogenous antiseptic N-chlorotaurine irreversibly inactivates Chlamydia pneumoniae and Chlamydia trachomatis." Journal of Medical Microbiology 67, no. 9 (2018): 1410–15. http://dx.doi.org/10.1099/jmm.0.000815.

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23

Roshchupkin, D. I., K. V. Kondrashova, and M. A. Murina. "Molecular characteristics and prediction of the reactive properties of N-chlorotaurine analogs." Biophysics 59, no. 6 (2014): 849–53. http://dx.doi.org/10.1134/s0006350914060207.

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24

Nagl, Markus, Roland Arnitz, and Michaela Lackner. "N-Chlorotaurine, a Promising Future Candidate for Topical Therapy of Fungal Infections." Mycopathologia 183, no. 1 (2017): 161–70. http://dx.doi.org/10.1007/s11046-017-0175-z.

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25

Wang, Lu, Barbara Belisle, Mansour Bassiri, et al. "Chemical Characterization and Biological Properties of NVC-422, a Novel, StableN-Chlorotaurine Analog." Antimicrobial Agents and Chemotherapy 55, no. 6 (2011): 2688–92. http://dx.doi.org/10.1128/aac.00158-11.

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ABSTRACTDuring oxidative burst, neutrophils selectively generate HOCl to destroy invading microbial pathogens. Excess HOCl reacts with taurine, a semi-essential amino acid, resulting in the formation of the longer-lived biogenerated broad-spectrum antimicrobial agent,N-chlorotaurine (NCT). In the presence of an excess of HOCl or under moderately acidic conditions, NCT can be further chlorinated, or it can disproportionate to produceN,N-dichlorotaurine (NNDCT). In the present study, 2,2-dimethyltaurine was used to prepare a more stableN-chlorotaurine, namely,N,N-dichloro-2,2-dimethyltaurine (NV

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26

Lackner, Michaela, Ulrike Binder, Martin Reindl, et al. "N-Chlorotaurine Exhibits Fungicidal Activity against Therapy-Refractory Scedosporium Species and Lomentospora prolificans." Antimicrobial Agents and Chemotherapy 59, no. 10 (2015): 6454–62. http://dx.doi.org/10.1128/aac.00957-15.

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ABSTRACTN-Chlorotaurine (NCT), a well-tolerated endogenous long-lived oxidant that can be applied topically as an antiseptic, was tested on its fungicidal activity againstScedosporiumandLomentospora, opportunistic fungi that cause severe infections with limited treatment options, mainly in immunocompromised patients. In quantitative killing assays, both hyphae and conidia ofScedosporium apiospermum,Scedosporium boydii, andLomentospora prolificans(formerlyScedosporium prolificans) were killed by 55 mM (1.0%) NCT at pH 7.1 and 37°C, with a 1- to 4-log10reduction in CFU after 4 h and a 4- to >

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27

Gstöttner, Michaela, Markus Nagl, Claus Pototschnig, and Andreas Neher. "Refractory Rhinosinusitis Complicating Immunosuppression: Application of N-Chlorotaurine, a Novel Endogenous Antiseptic Agent." ORL 65, no. 5 (2003): 303–5. http://dx.doi.org/10.1159/000075231.

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28

Coraça-Huber, Débora, Christoph G. Ammann, Manfred Fille, Johann Hausdorfer, Michael Nogler, and Markus Nagl. "Bactericidal Activity of N-Chlorotaurine against Biofilm-Forming Bacteria Grown on Metal Disks." Antimicrobial Agents and Chemotherapy 58, no. 4 (2014): 2235. https://doi.org/10.1128/AAC.02700-13.

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Many orthopedic surgeons consider surgical irrigation and debridement with prosthesis retention as a treatment option for postoperative infections. Usually, saline solution with no added antimicrobial agent is used for irrigation. We investigated the activity of N-chlorotaurine (NCT) against various biofilm-forming bacteria in vitro and thereby gained significant information on its usability as a soluble and well-tolerated active chlorine compound in orthopedic surgery. Biofilms of Staphylococcus aureus were grown on metal alloy disks and in polystyrene dishes for 48 h. Subsequently, they were

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29

CUNNINGHAM, Colm, F. Keith TIPTON, and B. F. Henry DIXON. "Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress." Biochemical Journal 330, no. 2 (1998): 939–45. http://dx.doi.org/10.1042/bj3300939.

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N-Chlorotaurine (taurine chloramine), formed by treating taurine with hypochlorous acid, was shown to decompose to sulphoacetaldehyde with a first-order rate constant of 9.9±0.5×10-4·h-1 at 37 °C in 0.1 M phosphate buffer, pH 7.4. Rat liver homogenates accelerated this decay in a process that was proportional to tissue-protein concentration and saturable, with maximum velocity (Vmax) and Km values of 0.28±0.01 nmol/min per mg of protein and 37±9 μM respectively. This activity was found to be lost on heat denaturation, but retained after dialysis. There was no detectable formation of sulphoacet

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30

Ammann, CExperimental Orthopaedics Innsbruck Medical University Innsbruck Austriahristoph G., Manfred Fille, Johann Hausdorfer, Michael Nogler, Markus Nagl, and Débora Coraça-Huber. "Influence of poly-N-acetylglucosamine in the extracellular matrix on N-chlorotaurine mediated killing of Staphylococcus epidermidis." New Microbiologica 37 (December 12, 2017): 361–64. https://doi.org/10.5281/zenodo.1110704.

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N–chlorotaurine (NCT) has recently been shown to have bactericidal activity against bacterial biofilm on metal discs (Coraca-Huber et al., 2014). In a biofilm, Staphylococcus epidermidis polymerizes poly-N-acetylglucosamine (PNAG) to form an extracellular matrix (ECM). Pseudomonas aeruginosa does not express this PNAG and has been shown to be highly susceptible to NCT. We compared the action of NCT on S. epidermidis 1457, a PNAG positive strain (SE1457) and S. epidermidis 1457- M10 an isogenic PNAG negative mutant (SE1457 M10). NCT-mediated killing was more effective and quicker on the P

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31

Nagl, M., A. Gruber, A. Fuchs, et al. "IMPACT OF N-CHLOROTAURINE ON VIABILITY AND PRODUCTION OF SECRETED ASPARTYL PROTEINASES OF CANDIDA." Mycoses 45, S2 (2002): 42–43. http://dx.doi.org/10.1111/j.1439-0507.2002.tb04674.x.

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32

Reeves, Emer P., Markus Nagl, Joseph O'Keeffe, Judy Kelly, and Kevin Kavanagh. "Effect of N-chlorotaurine on Aspergillus, with particular reference to destruction of secreted gliotoxin." Journal of Medical Microbiology 55, no. 7 (2006): 913–18. http://dx.doi.org/10.1099/jmm.0.46405-0.

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The fungistatic and fungicidal activity of N-chlorotaurine (NCT), a long-lived oxidant produced by stimulated neutrophils, was investigated. Physiological concentrations (75–100 μM) of NCT showed clear fungicidal activity against a range of Aspergillus isolates. Moreover, killing by NCT was significantly increased in the presence of ammonium chloride, explained by the formation of monochloramine by halogenation of ammonium. One clinical isolate of Aspergillus fumigatus was characterized for the production of the immunosuppressive agent gliotoxin, and NCT was shown to cause destruction of gliot

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33

Neher, Andreas, Markus Nagl, Elisabeth Appenroth, et al. "Acute Otitis Externa: Efficacy and Tolerability of N-Chlorotaurine, a Novel Endogenous Antiseptic Agent." Laryngoscope 114, no. 5 (2004): 850–54. http://dx.doi.org/10.1097/00005537-200405000-00011.

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34

Fürnkranz, Ursula, Markus Nagl, Waldemar Gottardi, Ulrich Matt, Horst Aspöck, and Julia Walochnik. "N-Chlorotaurine shows high in vitro activity against promastigotes and amastigotes of Leishmania species." Journal of Medical Microbiology 58, no. 10 (2009): 1298–302. http://dx.doi.org/10.1099/jmm.0.011155-0.

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Protozoan parasites of the genus Leishmania are the causative agents of life-threatening visceral as well as cutaneous and mucocutaneous leishmaniasis. First-line drugs are antimonials, but toxicity and resistance in some endemic areas cause serious problems. In the current study, the antileishmanial activity of the weak oxidant N-chlorotaurine (NCT) was investigated. NCT is a derivative of the amino acid taurine produced by granulocytes and monocytes during oxidative burst, but can also be synthesized chemically and used topically as an antiseptic at a concentration of 1 % (55 mM) in vivo. NC

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35

Gottardi, Waldemar, and Markus Nagl. "Chemical Properties of N-Chlorotaurine Sodium, a Key Compound in the Human Defence System." Archiv der Pharmazie 335, no. 9 (2002): 411–21. http://dx.doi.org/10.1002/1521-4184(200212)335:9<411::aid-ardp411>3.0.co;2-d.

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36

Efimenko, A. O., O. D. Stepanskyi, L. O. Bogomolny, and O. V. Ishchenko. "EFFECT OF N-CHLOROTAURINE ON BIOFILMS OF PATHOGENS ASSOCIATED WITH COMPLICATIONS OF DENTAL IMPLANTATION." Bulletin of Problems Biology and Medicine 1, no. 2 (2023): 432. http://dx.doi.org/10.29254/2077-4214-2023-2-169-432-437.

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37

Fürnkranz, Ursula, Markus Nagl, Waldemar Gottardi, Michael Duchêne, Horst Aspöck, and Julia Walochnik. "In vitro activity of N-chlorotaurine (NCT) in combination with NH4Cl against Trichomonas vaginalis." International Journal of Antimicrobial Agents 37, no. 2 (2011): 171–73. http://dx.doi.org/10.1016/j.ijantimicag.2010.09.006.

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38

Martini, C., A. Hammerer-Lercher, M. Zuck, et al. "Antimicrobial and Anticoagulant Activities ofN-Chlorotaurine,N,N-Dichloro-2,2-Dimethyltaurine, andN-Monochloro-2,2-Dimethyltaurine in Human Blood." Antimicrobial Agents and Chemotherapy 56, no. 4 (2012): 1979–84. http://dx.doi.org/10.1128/aac.05685-11.

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ABSTRACTThe aim of this study was to determine the potential application ofN-chlorotaurine (NCT),N,N-dichloro-2,2-dimethyltaurine (NVC-422), andN-monochloro-2,2-dimethyltaurine (NVC-612) as catheter lock solutions for the prevention of catheter blockage and catheter-related bloodstream infections by testing their anticoagulant and broad-spectrum antimicrobial activities in human blood. NCT, NVC-422, NVC-612, and control compounds were serially diluted in fresh human blood to evaluate the effects on prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, and direct t

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39

Ying, Q. L., M. Kemme, D. Saunders, and S. R. Simon. "Glycosaminoglycans regulate elastase inhibition by oxidized secretory leukoprotease inhibitor." American Journal of Physiology-Lung Cellular and Molecular Physiology 272, no. 3 (1997): L533—L541. http://dx.doi.org/10.1152/ajplung.1997.272.3.l533.

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Secretory leukoprotease inhibitor (SLPI) is one of the major physiological inhibitors protecting respiratory epithelium from attack by excess human leukocyte elastase (HLE), a serine protease released by neutrophils upon activation in response to inflammatory stimuli. Reaction with N-chlorotaurine, a major long-lived oxidant generated by activated neutrophils, oxidized all four methionine residues, but no other amino acids, in SLPI, resulting in substantial diminution of its elastase inhibitory activity. Oxidation of the P1' residue, Met73, accounted for most of the diminution in activity sinc

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40

Teuchner, Barbara, Idris D. Wibmer, Philipp Schaumann, Christof Seifarth, Julia Walochnik, and Markus Nagl. "N-chlorotaurine Inactivates Acanthamoeba and Candida albicans in the Porcine Ex Vivo Corneal Infection Model." Cornea 38, no. 8 (2019): 1011–16. http://dx.doi.org/10.1097/ico.0000000000001927.

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41

Nagl, Markus, Paul Hengster, Erich Semenitz, and Waldemar Gottardi. "The postantibiotic effect of N-chlorotaurine on Staphylococcus aureus. Application in the mouse peritonitis model." Journal of Antimicrobial Chemotherapy 43, no. 6 (1999): 805–9. http://dx.doi.org/10.1093/jac/43.6.805.

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42

Arnitz, Roland, Markus Stein, Petra Bauer, et al. "Tolerability of inhaled N-chlorotaurine in humans: a double-blind randomized phase I clinical study." Therapeutic Advances in Respiratory Disease 12 (January 1, 2018): 175346661877895. http://dx.doi.org/10.1177/1753466618778955.

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Background: N-chlorotaurine (NCT), a long-lived oxidant produced by human leukocytes, can be synthesized chemically and used topically as a well-tolerated antiseptic to different body regions including sensitive ones. The aim of this study was to test the tolerability of inhaled 1% NCT in aqueous solution upon repeated application. Methods: The study was performed double-blind and randomized with a parallel test group (1% NCT) and control group (0.9% NaCl as placebo). There were two Austrian centres involved, the hospitals, Natters and Vöcklabruck. Healthy, full age volunteers were included, 1

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43

Wirleitner, Barbara, Gabriele Neurauter, Markus Nagl, and Dietmar Fuchs. "Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC." Immunology Letters 93, no. 2-3 (2004): 143–49. http://dx.doi.org/10.1016/j.imlet.2004.03.006.

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44

Leiter, Hannes, Stephanie Toepfer, Petra Messner, et al. "Microbicidal activity of N-chlorotaurine can be enhanced in the presence of lung epithelial cells." Journal of Cystic Fibrosis 19, no. 6 (2020): 1011–17. http://dx.doi.org/10.1016/j.jcf.2020.03.005.

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45

Hacioglu, Mayram, Ozlem Oyardi, Fatima Nur Yilmaz, and Markus Nagl. "Comparative Fungicidal Activities of N-Chlorotaurine and Conventional Antiseptics against Candida spp. Isolated from Vulvovaginal Candidiasis." Journal of Fungi 8, no. 7 (2022): 682. http://dx.doi.org/10.3390/jof8070682.

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N-chlorotaurine (NCT), the N-chloro derivative of the amino acid taurine, is a long-lived oxidant produced by stimulated human leucocytes. NCT has antimicrobial activities which are generally enhanced in the presence of organic material. The aim of this study was to investigate fungicidal effects of NCT and conventional antiseptics against Candida isolated from vulvovaginal candidiasis (VVC). Chlorhexidine (CHX, 1.6%), octenidine dihydrochloride (OCT, 0.08%), povidone iodine (PVP-I, 8%), boric acid (8%), and NCT (0.1% (5.5 mM)) were evaluated against forty-four Candida isolates, according to E

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Speth, Cornelia, Günter Rambach, Andrea Windisch, Magdalena Neurauter, Hans Maier, and Markus Nagl. "Efficacy of Inhaled N-Chlorotaurine in a Mouse Model of Lichtheimia corymbifera and Aspergillus fumigatus Pneumonia." Journal of Fungi 8, no. 5 (2022): 535. http://dx.doi.org/10.3390/jof8050535.

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N-chlorotaurine (NCT) can be used topically as a well-tolerated anti-infective at different body sites. The aim of this study was to investigate the efficacy of inhaled NCT in a mouse model of fungal pneumonia. Specific pathogen-free female C57BL/6JRj seven-week-old mice were immune-suppressed with cyclophosphamide. After 4 days, the mice were inoculated intranasally with 1.5 × 10E7 spores of Lichtheimia corymbifera or 1.0 × 10E7 spores of Aspergillus fumigatus. They were randomized and treated three times daily for 10 min with aerosolized 1% NCT or 0.9% sodium chloride starting 1 h after the

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Uchio, Eiichi, Hirotoshi Inoue, and Kazuaki Kadonosono. "Antiadenoviral effects of N-chlorotaurine in vitro confirmed by quantitative polymerase chain reaction methods." Clinical Ophthalmology Volume 4 (November 2010): 1325–29. http://dx.doi.org/10.2147/opth.s14282.

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Huemer, Hartwig P., Markus Nagl, and Eveline U. Irschick. "In vitro Prevention of Vaccinia and Herpesvirus Infection Spread in Explanted Human Corneas by N-Chlorotaurine." Ophthalmic Research 43, no. 3 (2010): 145–52. http://dx.doi.org/10.1159/000253846.

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Nagl, Markus, Barbara Teuchner, Ernst Pöttinger, Hanno Ulmer, and Waldemar Gottardi. "Tolerance of N-Chlorotaurine, a New Antimicrobial Agent, in Infectious Conjunctivitis – A Phase II Pilot Study." Ophthalmologica 214, no. 2 (2000): 111–14. http://dx.doi.org/10.1159/000027477.

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Efimenko, Anastasiia O., Oksana V. Ishchenko, Iryna P. Koshova, Bohdan V. Murashevych, and Dmytro O. Stepanskyi. "THE PERSPECTIVE OF N-CHLOROTAURINE INFLUENCE ON MULTI-DRUF RESISTANT MICROORGANISMS ASSOCIATED WITH DENTAL IMPLANTATION FAILURE." Clinical and Preventive Medicine, no. 8 (December 31, 2023): 68–74. http://dx.doi.org/10.31612/2616-4868.8.2023.08.

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Introduction: Microorganisms colonizing the surface of dental implants can form biofilms that protect their microcolonies from mechanical impact, antimicrobial compounds, and immune factors. Prophylactic use of antibiotics during dental implantation can exert selective pressure on the development of antimicrobial resistance. In this context, N-chlorotaurine (NCT) is a promising compound to combat resistant agents. The aim is to investigate the efficacy of NCT against pathogens associated with dental implant complications. Materials and methods. A buffered 1% NCT solution adjusted t

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