Relevant bibliographies by topics / N-glycosylation / Dissertations / Theses
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Dissertations / Theses on the topic 'N-glycosylation'

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Published: 4 June 2021
Last updated: 26 July 2025

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1

Karg, Saskia Ruth. "N-glycosylation engineering in tobacco /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17989.

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2

Harthill, Jean Elizabeth. "N-glycosylation of horseradish peroxidase." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292612.

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3

Warren, C. E. "N-glycosylation in mice and rats." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315795.

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4

Hills, Anna E. "Control of monoclonal antibody N-glycosylation." Thesis, University of Kent, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344101.

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5

Huffman, Jennifer Elizabeth. "Genetic analysis of protein N-glycosylation." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10038.

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The majority of human proteins are post-translationally modified by covalent addition of one or more complex oligosaccharides (glycans). Alterations in glycosylation processing are associated with numerous diseases and glycans are attracting increasing attention both as disease biomarkers and as targets for novel therapeutic approaches. Using a recently developed high performance liquid chromatography (HPLC) method for high-throughput glycan analysis, genome-wide association studies (GWAS) of 33 directly measured and 13 derived N-glycan features were performed in 3533 individuals from four Eur
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6

Luz, Johanna Da. "Aspects of N-glycosylation in human IgE /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-130-6.

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7

Wood, Alison. "N-linked protein glycosylation in Helicobacter species." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nlinked-protein-glycosylation-in-helicobacter-species(ef97ffdd-aca4-40ff-b52b-7b8ca030bc82).html.

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N-linked protein glycosylation involves the transfer of a glycan onto an Asparagine residue (N) of a polypeptide chain. It is common in Eukaryotes and has recently been observed in Prokaryotes, most notably in Campylobacter jejuni. The C. jejuni N-linked glycosylation system is encoded on a single pgl gene locus that also functions when expressed in Escherichia coli. The key enzyme involved in N-linked protein glycosylation is encoded by the pglB gene and transfers lipid-linked glycan onto N residues of glycoproteins in the periplasm. It is clear from accumulating genome sequence data that pgl
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8

Murray, Anne Riché. "The functional significance of rhodopsin's N-linked glycosylation." Oklahoma City : [s.n.], 2009.

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9

Karlsson, Gunilla Birgitta. "Effects of the imino sugar N-butyldeoxynojirimycin on protein N-linked glycosylation." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333246.

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10

Amatayakul, Supavadee. "Changes in N-glycosylation associated with development and pathology." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253150.

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11

Frost, Helen. "N-linked protein glycosylation in Campylobacter and Helicobacter species." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/nlinked-protein-glycosylation-in-campylobacter-and-helicobacter-species(ca49728c-1406-463f-bead-99d7cf336cb9).html.

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N-linked protein glycosylation is the enzymatic transfer of a carbohydrate glycan to an asparagine residue of a polypeptide, catalysed by an N-oligosaccharyl transferase(OTase). Bacterial N-glycosylation is best understood in the foodborne pathogen Campylobacter jejuni, in which a heptasaccharide glycan is built at cytoplasmic face of the inner membrane, flipped to the periplasm and transferred to a polypeptide enbloc. C. jejuni encodes each of the proteins required for the N-glycosylation pathway in a single genetic region, termed the pgl locus. Homologues of the gene encoding the C. jejuni O
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12

Klarić, Lucija. "Genetic analysis of IgG N-glycosylation in health and disease." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31097.

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Glycosylation is among the most common post-translational protein modifications. Glycans are complex carbohydrates attached to the surface of many proteins, but are rarely extensively studied in a high-throughput manner. However, there is an increasing evidence of their involvement in various physiological processes and diseases. Glycosylation of Immunglobulin G was shown to be important in adaptive immunity, where it can act as a "safety switch" for different types of the immune response. Although the main enzymes of the glycosylation pathway are known, little is understood about how this tem
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13

Scoponi, Giulia. "Lewis acid catalysed direct glycosylation of N-acetyl-D-glucosamine." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14450/.

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Incorporation of the relevant monosaccharide N-Acetyl-D-glucosamine (GlcNAc) into synthetic oligosaccharides by chemical glycosylation is still a very challenging object of studies, since direct reactions are low yielding. This issue is generally ascribed to its low solubility in common solvents and to the formation of a poorly reactive oxazoline intermediate, which is typically bypassed by introducing extra synthetic steps to avoid the presence of the NHAc moiety during glycosylation. Recently, a new direct Lewis acids-catalysed GlcNAc-ylation protocol has been disclosed, with acylated donors
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14

Yudkin, Ben. "A genetical investigation of N-linked glycosylation in Drosophila melanogaster." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318453.

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15

Mehta, Anand. "The role of N-linked glycosylation in Hepatitis B virus." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284539.

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16

Lukose, Vinita. "Priming and processing glycosyltransferases in bacterial N-linked glycosylation pathways." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101550.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Bacterial cell surfaces prominently feature a variety of complex glycoconjugates. Although these structures are very diverse, the biosynthesis of these glycoconjugates shares common themes. In particular, a priming glycosyltransferase or phosphoglycosyltransferase (PGT) initiates the biosynthesis of glycans by transferring a Cl'-phosphosugar onto a polyprenol phosphate substrate. The membrane-bound polyprenol diphosphosugar pr
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17

Wang, Hao. "Functional Studies of N-glycosylation in Human Corin." Cleveland State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=csu1500479066332159.

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18

Cabanes-Macheteau, Marion. "N-glycosylation d'un anticorps recombinant produit dans du tabac transgénique." Rouen, 1998. http://www.theses.fr/1998ROUES071.

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La production de protéines recombinantes d'intérêt thérapeutique dans des plantes transgéniques connaît actuellement un essor considérable. En outre, des anticorps monoclonaux fonctionnels ont pu être exprimés dans du tabac transgénique. La plupart des protéines d'intérêt sont N-glycosylées et cette N-glycosylation est fondamentale à l'acquisition par la protéine de la conformation active. Afin d'évaluer la capacité des cellules de tabac à glycosyler des protéines recombinantes complexes, nous avons analysé dans un premier temps, la N-glycosylation de glycoprotéines endogènes de tabac, ainsi q
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19

Sabry, Zaki Tlep Sahar. "Identification of the molecular origins of disease in a cohort of patients with suspected congenital disorders of glycosylation (CDG)." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066715/document.

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Contexte : Les désordres congénitaux de la glycosylation (CDGs) sont des maladies rares dues à des mutations dans des gènes codant pour des protéines de la biosynthèse des glycoconjugués. Les CDGs présentent avec des glycoprotéines sériques hypoglycosylées avec un spectre clinique large. Le diagnostic moléculaire des CDG est important dans le cadre du diagnostic prénatal et du développement de stratégies thérapeutiques. Objectif : Déterminer les mutations causales dans une cohorte de cas suspects de CDG. Deux cas ont fait l’objet d’explorations biochimiques afin de comprendre les conséquences
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20

Anthony, Colin Scott. "The importance of N-linked glycosylation on the N-domain of angiotensin-I converting enzyme." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10051.

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Angiotensin-I converting enzyme (ACE) is an important drug target in the treatment of heart disease due to its role in the regulation of blood pressure. ACE contains two domains, the N- and C-domains, both of which are catalytically active and heavily glycosylated. Glycosylation is one of the most important forms of post-translational modification, having a wide range of functions including protein folding, modulation of the immune response, and providing targeting signals. Glycosylation is required for the expression of active ACE and structural studies of ACE have been fraught with severe di
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21

Imjeti, Naga Sailaja. "Role of cholesterol and N-glycosylation in apical sorting of GPI- APs in polarized epithelial FRT cells." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00682284.

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Epithelial cells represent the ability to polarize with an apical and basolateral domains which differ markedly in proteins, lipid composition and therefore in function. This asymmetry reflects the ability of epithelial cells to sort newly synthesized proteins and lipid to either cell surface. While the signals responsible for basolateral targeting of the proteins have been clearly understood, the situation regarding the apical sorting of proteins is more obscure. We have previously shown that differently from basolateral GPI-APs oligomerization in the Golgi apparatus is necessary for apical s
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22

Stagljar, Igor. "N-linked glycosylation in the yeast Saccharomyces cerevisiase : the ALG8 locus /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10916.

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23

Popov, Milka. "Sugars in space, N-glycosylation mutants of the erythrocyte anion exchanger." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0027/NQ49822.pdf.

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24

Jia, Ying. "Analysis of the neuroprotective function and the N-glycosylation progranulin (PGRN)." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/7726.

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Recent studies have identified null mutations in the progranulin (PGRIV) gene as the cause of pathogenesis of Frontotemporal lobe dementia (FTLD). It was found that PGRN protein levels are reduced in patients due to haploinsufficiency. However, the functions of progranulin in the central nervous system remain poorly characterized. We hypothesized that PGRN plays a role in protecting mouse cortical neurons from aggregated amyloid-beta, NMDA and H₂0₂ toxicity. Neuronal cultures were incubated in conditioned medium containing PGRN protein, or infected with lentivirus carrying PGRN fusion gene, th
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25

Rajakarier, Jesuthasan Anton. "Preparation and uses of synthetic analogues of cellular N-glycosylation pathway." Thesis, University of Stirling, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311639.

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26

Chang, Michelle M. (Michelle Miran). "Biochemical and biophysical investigations of N-linked glycosylation pathways in archaea." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/97981.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, February 2015.<br>Cataloged from PDF version of thesis. "December 2014."<br>Includes bibliographical references.<br>Asparagine-linked glycosylation is an abundant and complex protein modification conserved among all three domains of life. Much is known about N-glycan assembly in eukaryotes and selected bacteria, in which the oligosaccharyltransferase (OTase) carries out the en bloc transfer of glycans from polyprenyl-PP-linked donors onto asparagine side chains of acceptor proteins. The first aim of this thesis is
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27

Bonomelli, Camille. "Antigenic and immunomodulatory properties of HIV-1 gp120 N-linked glycosylation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:6c003958-e16d-4a70-9e58-8f1c98122376.

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The HIV-1 surface glycoprotein, gp120, is made of a rapidly mutating protein core and an extensive carbohydrate shield which are, respectively, encoded by the viral genome and synthesised by the host cell. In contrast to host cell glycoproteins however, gp120 contains a population of unprocessed oligomannose-type glycans that interact with host lectins, promote HIV infection, and alter cell signalling. They also form the basis of the epitopes of several broadly neutralising antibodies isolated against HIV, making them a key feature for immunogen design. The mechanistic basis of how HIV glycans
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28

Moharir, Akshay. "Role of N-glycosylation in trafficking and stability of human CLN5." Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/14143.

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Master of Science<br>Division of Biology<br>Stella Y Lee<br>Neuronal Ceroid Lipofuscinoses (NCLs) are a group of lysosomal storage diseases that are characterized by accumulating autofluorescent lipopigments in cells. NCLs are a form of progressive neurodegenerative diseases with symptoms ranging from blindness, loss of speech and motor activities to ataxia and seizures. Patients do not live to adulthood in most cases, making it prevalent in children. Among the many genes that cause NCL, CLN5 leads to different forms of NCL (infantile, late infantile, juvenile, and adult). CLN5 protein resides
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29

Singh, Richa. "N-Glycosylation, Localization and Trafficking of endogenous NKCC1 in COS7 cells." Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1389704405.

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30

Saleh, Ali. "Impact de la matrice extracellulaire sur la migration des cellules souches de glioblastome : un modèle tridimensionnel de culture et une nouvelle stratégie thérapeutique." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT006/document.

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Les glioblastomes multiformes (GBM) comptent parmi les tumeurs au pronostic le plus sombre. L’extraordinaire capacité invasive des cellules tumorales rend toutes les interventions thérapeutiques actuelles totalement impuissantes. Une sous-population de Cellules Souches de Glioblastome (CSG) hautement invasive est responsable de la récurrence tumorale. Dans le cerveau, les GBM migrent principalement le long des vaisseaux sanguins au sein de l’espace périvasculaire riche en laminine, fibronectine et collagène ainsi qu’en suivant l’alignement des fibres myélinisées du corps calleux. La Matrice Ex
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31

Schulz, Benjamin Luke. "Analysis and mechanisms of site-specific N-linked protein glycosylation by oligosaccharyltransferase /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17559.

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32

MARRA, ALBERTO. "Reactions d'o-glycosylation impliquant la glucosamine, la galactosamine et l'acide n-acetylneuraminique." Paris 6, 1989. http://www.theses.fr/1989PA066335.

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Plusieurs derives de la d-glucosamine, comportant un groupement p-methoxybenzylidene en position 2 (bases de schiff), ont ete prepares. Leur efficacite vis-a-vis de reactions de glycosylation a ete etudiee. L'application de la reaction de lithiation reductrice a une serie de thiophenylglycosides et glycosyl phenyl sulphones permet d'obtenir les glycals correspondants en rendement eleve. Un de ces glycals a ete soumis a la reaction d'azidonitration. La synthese de deux disaccharides, constituant des fragments du dermatane sulfate, a ete effectuee par glycosylation avec le bromure et le trichlor
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33

Rayon, Catherine. "La N-glycosylation chez les plantes. Etude d'une glycoprotéine modèle : la phytohémagglutinine." Rouen, 1998. http://www.theses.fr/1998ROUES007.

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La production de protéines d'intérêt thérapeutique dans des plantes transgéniques suppose que la cellule végétale soit capable d'effectuer les modifications post-traductionnelles, en particulier la N-glycosylation, indispensables à la biosynthèse d'une protéine biologiquement active et stable. Les données actuelles relatives à la N-glycosylation des protéines végétales étant encore parcellaires, nous avons cherché à réaliser une analyse comparée de la biosynthèse et la maturation des N-glycannes dans différents systèmes constitutifs du règne végétal et au sein de différents organes d'une même
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34

Bardor, Muriel. "Humanisation de la N-glycosylation d'anticorps recombinants produits dans des plantes transgéniques." Rouen, 2001. http://www.theses.fr/2001ROUES021.

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La production de protéines recombinantes à intérêt thérapeutique dans les plantes transgéniques est un domaine en pleine expansion. Afin d'évaluer la capacité des plantes à N-glycosyler ces protéines, nous avons réalisé une analyse comparée de la N-glycosylation d'un anticorps produit chez la souris et dans des plantes transgéniques (planticorps). Cette étude a montré que l'anticorps produit chez la souris est N-glycosylé par des N-glycannes de mammifères, alors que le planticorps porte des N-glycannes végétaux substitués par des résidus β1,2-xylose et α1,3-fucose. L'absence de ces épitopes ch
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35

Cain, Joel Aaron. "Evaluating the Relationship Between N-Glycosylation and Protein Stability in Campylobacter jejuni." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25679.

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The major enteric pathogen Campylobacter jejuni was the first prokaryote demonstrated to perform N-linked protein glycosylation. Although protein post-translational modifications involving glycan attachment to proteins are strongly associated with virulence, the mechanisms and functions of N-glycosylation remains to be determined. This thesis aimed to address some of the outstanding questions regarding the role of N-glycosylation in C. jejuni. Through application of quantitative proteomics we assessed the global effect of N-glycosylation to establish a causal relationship between the proteo
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36

Li, Xingang. "Heritability enrichment of immunoglobulin G N-glycosylation relevant genes in specific tissues." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2020. https://ro.ecu.edu.au/theses/2386.

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Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with IgG N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain. In this study, firstly, I leveraged data from GWAS summary statistics for 8,090 Europeans, and large-scale expression quantitative trait loci (eQTL) data from the genotype-tissue expression of 53 types of tissues (GTEx v7), to derive a linkage disequilibrium score for the specific expression of genes (LDSC-SEG) and conduct a transcriptome-wide association study (TWAS). I identified 55 genes whose pred
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37

Gücüm, Sevinc [Verfasser], and Ingrid [Akademischer Betreuer] Lohmann. "Modeling hypo-N-glycosylation in medaka, Oryzias latipes, to decipher mechanisms of Congenital Disorders of Glycosylation / Sevinc Gücüm ; Betreuer: Ingrid Lohmann." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/123567469X/34.

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38

Villers, Corinne. "Origine et rôle du matériel oligosaccharidique soluble libéré lors du processus de N-glycosylation." Lille 1, 1994. http://www.theses.fr/1994LIL10079.

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La biosynthese d'une n-glycosylproteine necessite la coordination de deux voies metaboliques: celle du glycanne via le cycle des dolichols d'une part et celle de l'accepteur proteique d'autre part. Nous proposons qu'une regulation de ce processus s'effectue grace a la liberation de materiel oligosaccharidique soluble. Ce materiel est heterogene, constitue d'oligosaccharides phosphates et d'oligosaccharides neutres possedant une ou deux n-acetylglucosamine(s) a leur extremite reductrice et pourrait etre le temoin de trois points de regulation: les oligosaccharides phosphates, resultat d'un by p
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39

Pacccalet, Thomas. "Sialylation in planta : Potentiel endogène et reconstitution par transgénèse." Rouen, 2006. http://www.theses.fr/2006ROUES006.

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Les plantes sont des systèmes d'expression de glycoprotéines thérapeutiques recombinantes performants, ne présentant pas d'agents pathogènes transmissibles à l'homme. Au contraire des mammifères, les N-glycannes végétaux ne possèdent pas d'acides sialiques terminaux, comme le Neu5Ac. Ces résidus contrôlent la demi-vie de nombreuses glycoprotéines circulantes. L'absence de Neu5Ac peut entraîner la perte d'activités de ces protéines. Après avoir vérifié l'absence d'acides sialiques dans la cellule végétale, nous avons tenté de détourner l'activité de la Kdo-8-P synthase végétale pour synthétiser
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40

Carbonari, Gioia <1983&gt. "Identification of the N-Linked Glycosylation Sites of the Transcription Factor Rest and Effect of Glycosylation on DNA Binding and Transcriptional Activity." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4288/1/Carbonari_Gioia_tesi.pdf.

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REST is a zinc-finger transcription factor implicated in several processes such as maintenance of embryonic stem cell pluripotency and regulation of mitotic fidelity in non-neuronal cells [Chong et al., 1995]. The gene encodes for a 116-kDa protein that acts as a molecular platform for co-repressors recruitment and promotes modifications of DNA and histones [Ballas, 2005]. REST showed different apparent molecular weights, consistent with the possible presence of post-translational modifications [Lee et al., 2000]. Among these the most common is glycosylation, the covalent attachment of carboh
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Carbonari, Gioia <1983&gt. "Identification of the N-Linked Glycosylation Sites of the Transcription Factor Rest and Effect of Glycosylation on DNA Binding and Transcriptional Activity." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4288/.

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REST is a zinc-finger transcription factor implicated in several processes such as maintenance of embryonic stem cell pluripotency and regulation of mitotic fidelity in non-neuronal cells [Chong et al., 1995]. The gene encodes for a 116-kDa protein that acts as a molecular platform for co-repressors recruitment and promotes modifications of DNA and histones [Ballas, 2005]. REST showed different apparent molecular weights, consistent with the possible presence of post-translational modifications [Lee et al., 2000]. Among these the most common is glycosylation, the covalent attachment of carboh
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42

Leprovost, Savignien. "SweetBiοΡharm : Sweet engineering οf the green micrοalgae Chlamydοmοnas reinhardtii fοr biοpharmaceuticals prοductiοn". Electronic Thesis or Diss., Normandie, 2024. https://theses.hal.science/tel-04903810.

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Le marché des biomédicaments atteindra 389 milliards de dollars en 2024. Sur ce marché, les glycoprotéines recombinantes représentent à ce jour environ 70% des biomédicaments commercialisés. La production de ces molécules avec les modèles mammifères actuels tels que les cellules CHO (Chinese Hamster Ovary) s’avère onéreuse. En effet, le risque important de contamination des cultures de cellules mammifères par des agents pathogènes et leurs conditions de croissance exigeantes justifient la recherche et le développement de modèles de production alternatifs. Cependant, il est bien connu que les m
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43

Pang, Ting-kai Ronald. "Role of N-linked glycosylation on the function and expression of the human secretin receptor /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20381530.

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44

Dulary, Eudoxie. "N-glycosylation et pathologies associées : étude de deux acteurs majeurs Man2C1 et Gdt1." Thesis, Lille 1, 2017. http://www.theses.fr/2017LIL10048/document.

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Une altération du processus de N-glycosylation des protéines peut conduire à l’apparition de pathologies comme le cancer ou les "Congenital Disorders of Glycosylation" (CDG). La première partie de mon travail de thèse a porté sur l’étude de l’implication de la Man2C1 dans la cancérogenèse de la prostate. La Man2C1 est une glycosidase impliquée dans le processus ERAD « Endoplasmic reticulum associated degradation ». Nous avons montré le transfert de précurseurs oligosaccharidiques incomplets de type Man9Gn2 et Man5Gn2 sur les protéines, ainsi qu’une diminution de l’antennarisation des N-glycann
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Norring, Sarah A. "N-Glycosylation Modulates Gating and Antibiotic Block of the Human Potassium Channel, hERG1A." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3616.

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Arrhythmias are often caused by aberrant ion channel activity, resulting in remodeling of the cardiac action potential. Two K + currents, IKs and IKr, contribute to phase III repolarization of the human cardiac action potential. Human ether-a-go-go-related gene 1 (hERG1), a voltage-gated potassium channel, underlies IKr. Alterations in the repolarization phase of the action potential, and in particular IKr, can lead to arrhythmias, long or short QT syndrome, heart disease, and sudden cardiac death. HERG1A has two putative N-glycosylation sites located in the S5-S6 linker region, one of which
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46

Planinc, Ana. "Detection of changes in n-glycosylation profiles of therapeutic glycoproteins using LC-MS." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/241427/4/Table.pdf.

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Biopharmaceuticals are becoming one of the most promising drugs on the market mainly due to their successful treatment of a vast array of serious diseases, such as cancers, immune disorders, and infections. Structurally, biopharmaceuticals are proteins and it is important to mention that more than 60 % of biopharmaceuticals are glycosylated. Glycosylation is one of the most common posttranslational modifications. It is also the most demanding and the most complex posttranslational modification. The research showed that glycosylation can significantly impact on the safety, efficiency, and quali
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47

Parrish, Austin R. "Effect of hybrid/complex N-glycosylation on cardiac voltage-gated ion channel expression." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1558106533403433.

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48

Ogier-Denis, Eric. "La n-glycosylation : marqueur precoce de la differenciation enterocytaire des cellules ht-29." Paris 5, 1989. http://www.theses.fr/1989PA05S002.

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Nous avons etudie les modifications des structures oligosaccharidiques n-liees presentes sur les glycoproteines au cours de la differenciation enterocytaire des cellules ht-29, derivees d'un adenocarcinome humain d'origine colique. Les cellules ht-29, cultivees en presence de 25 mm de glucose, demeurent totalement indifferenciees, alors que les memes cellules, cultivees en absence de glucose, developpent apres confluence cellulaire, une differenciation enterocytaire typique, caracterisee par la polarisation de la monocouche cellulaire, l'apparition de bordures en brosse au pole apical des cell
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49

Russell, Alyce Christine. "The N-Glycosylation of immunoglobulin G as a novel biomarker of Parkinson’s disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2015. https://ro.ecu.edu.au/theses/1617.

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For neurodegenerative diseases, interventions during the early stages of the disease, before significant neurodegeneration has occurred, are associated with an increased probability of slowing or halting the disease process. In order to intervene early, it is essential that an accurate diagnosis is obtained and that disease progression can be monitored. This is particularly relevant for Parkinson’s disease (PD; International Classification of Diseases version 10) because significant neurodegeneration has already occurred by the time the clinical motor symptoms are present. Therefore, the devel
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50

SIRINI, CAMILLA. "N-glycosylation inhibition hinders immunosuppressive tumor microenvironment cells improving CAR T cell efficacy." Doctoral thesis, Università Vita-Salute San Raffaele, 2023. https://hdl.handle.net/20.500.11768/137017.

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Adoptive transfer of CAR T cells demonstrated impressive results against B-cell malignancies, but still limited efficacy against solid tumors. In this context, multiple challenges need to be overcome, including poor tumor recognition and strong immunosuppression within the tumor microenvironment (TME). Our Unit has recently reported that pharmacological inhibition of N-glycan synthesis in cancer cells increases CAR T cell efficacy by improving tumor recognition and preventing T cell exhaustion. In this project, we investigated the role of N-glycosylation blockade on TME cells in the context of
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