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1

Xiu, Kemao, Jianchuan Wen, Nuala Porteous, and Yuyu Sun. "Controlling bacterial fouling with polyurethane/N-halamine semi-interpenetrating polymer networks." Journal of Bioactive and Compatible Polymers 32, no. 5 (2017): 542–54. http://dx.doi.org/10.1177/0883911516689334.

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N-halamine-based interpenetrating polymer networks were developed as a simple and effective strategy in the preparation of antimicrobial polymers. An N-halamine monomer, N-chloro-2, 2, 6, 6-tetramethyl-4-piperidyl methacrylate, was incorporated into polyurethane in the presence of a cross-linker and an initiator. Post-polymerization of the monomers led to the formation of polyurethane/ N-halamine semi-interpenetrating polymer networks. The presence of N-halamines in the semi-interpenetrating polymer networks was confirmed by attenuated total reflectance infrared, water contact angle, and energ
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2

Chylińska, Marta, and Halina Kaczmarek. "Thermal degradation of biocidal organic N-halamines and N-halamine polymers." Thermochimica Acta 583 (May 2014): 32–42. http://dx.doi.org/10.1016/j.tca.2014.03.009.

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3

Cheng, Chi-Hui, Han-Cheng Liu, and Jui-Che Lin. "Surface Modification of Polyurethane Membrane with Various Hydrophilic Monomers and N-Halamine: Surface Characterization and Antimicrobial Properties Evaluation." Polymers 13, no. 14 (2021): 2321. http://dx.doi.org/10.3390/polym13142321.

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Reducing microbial infections associated with biomedical devices or articles/furniture noted in a hospital or outpatient clinic remains a great challenge to researchers. Due to its stability and low toxicity, the N-halamine compound has been proposed as a potential antimicrobial agent. It can be incorporated into or blended with the FDA-approved biomaterials. Surface grafting or coating of N-halamine was also reported. Nevertheless, the hydrophobic nature associated with its chemical configuration may affect the microbial interactions with the chlorinated N-halamine-containing substrate. In th
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4

Duan, Linlin, Wei Huang, and Yatao Zhang. "High-flux, antibacterial ultrafiltration membranes by facile blending with N-halamine grafted halloysite nanotubes." RSC Advances 5, no. 9 (2015): 6666–74. http://dx.doi.org/10.1039/c4ra14530e.

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5

Kou, Lei, Jie Liang, Xuehong Ren, et al. "Novel N-halamine silanes." Colloids and Surfaces A: Physicochemical and Engineering Aspects 345, no. 1-3 (2009): 88–94. http://dx.doi.org/10.1016/j.colsurfa.2009.04.047.

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6

Liang, J., R. Wu, J. W. Wang, et al. "N-halamine biocidal coatings." Journal of Industrial Microbiology & Biotechnology 34, no. 2 (2006): 157–63. http://dx.doi.org/10.1007/s10295-006-0181-5.

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7

Eknoian, M. W., and S. D. Worley. "New N-Halamine Biocidal Polymers." Journal of Bioactive and Compatible Polymers 13, no. 4 (1998): 303–14. http://dx.doi.org/10.1177/088391159801300405.

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8

Kocer, Hasan B., Idris Cerkez, S. D. Worley, R. M. Broughton, and T. S. Huang. "Polymeric Antimicrobial N-Halamine Epoxides." ACS Applied Materials & Interfaces 3, no. 8 (2011): 2845–50. http://dx.doi.org/10.1021/am200351w.

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9

Tsao, Te Chen, Delbert E. Williams, Christopher G. Worley, and S. Davis Worley. "Novel N-halamine disinfectant compounds." Biotechnology Progress 7, no. 1 (1991): 60–66. http://dx.doi.org/10.1021/bp00007a010.

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10

Wang, Fei, Liqian Huang, Peng Zhang, Yang Si, Jianyong Yu, and Bin Ding. "Antibacterial N-halamine fibrous materials." Composites Communications 22 (December 2020): 100487. http://dx.doi.org/10.1016/j.coco.2020.100487.

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11

Li, Lin, Kaikai Ma, Yin Liu, et al. "Regenerablity and Stability of Antibacterial Cellulose Containing Triazine N-halamine." Journal of Engineered Fibers and Fabrics 11, no. 1 (2016): 155892501601100. http://dx.doi.org/10.1177/155892501601100105.

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A reactive triazine derivative, 2,4-dichloro-6-hydroxy-1,3,5-triazine (DCHT), was prepared through the controlled hydrolysis of cyanuric chloride in water solution. The reaction was characterized with 13C NMR study. The reaction solutions could be directly used to treat cellulose fibers. A pad-dry-cure method was employed to immobilize the triazine derivative onto cotton. The covalently bound triazine moieties on cotton could be transformed into N-halamine structures after a chlorine bleaching treatment. The biocidal efficacies of the treated samples with different chlorine loadings were furth
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12

GODDARD, J. M., and J. H. HOTCHKISS. "Rechargeable Antimicrobial Surface Modification of Polyethylene." Journal of Food Protection 71, no. 10 (2008): 2042–47. http://dx.doi.org/10.4315/0362-028x-71.10.2042.

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Polyethylene films were surface modified, to incorporate amine and amide functionalities, and subsequently were evaluated for their ability to recharge the antimicrobial N-halamine structures after contact with sodium hypochlorite, a common food-approved sanitizer. Surfaces were tested for chlorine retention and release, as well as antimicrobial activity against microorganisms relevant to food quality and food safety, including Escherichia coli K-12, Pseudomonas fluorescens, Bacillus cereus, and Listeria monocytogenes. N-Halamine functionalized polyethylene exhibited chlorine rechargeability,
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13

Huang, Chengbo, Ying Liu, Zhiguang Li, Rong Li, Xuehong Ren, and Tung-Shi Huang. "N-halamine antibacterial nanofibrous mats based on polyacrylonitrile and N-halamine for protective face masks." Journal of Engineered Fibers and Fabrics 14 (January 2019): 155892501984322. http://dx.doi.org/10.1177/1558925019843222.

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The main objective of this study was to develop antibacterial materials based on polyacrylonitrile for potential application in protective face masks to combat airborne pathogens. To achieve biocidal properties, 1-chloro-2, 2, 5, 5-tetramethyl-4-imidazolidinone as a kind of N-halamine was introduced into the polyacrylonitrile nanofibers by an electrospinning technique to form nanofibers by an electrospinning technique to form polyacrylonitrile/1-chloro-2, 2, 5, 5-tetramethyl-4-imidazolidinone-5% nanofibers. Scanning electron microscopy and Fourier transformed infrared spectroscopy were employe
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14

Ma, Zhipeng, Xinghuan Lin, and Xuehong Ren. "Cellulose Acetate Nanofibrous Membranes for Antibacterial Applications." Recent Patents on Nanotechnology 13, no. 3 (2020): 181–88. http://dx.doi.org/10.2174/1872210513666190603084519.

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Background: N-halamine antibacterial materials have been extensively explored over the past few decades due to their fast inactivation of a broad spectrum of bacterial and rechargeability. Electrospun nanofibers loaded with N-halamines have gained great attention because of their enhanced antibacterial capability induced by the larger specific surface area. The patents on electrospun nanofibers (US20080679694), (CN2015207182871) helped in the method for the preparation of nanofibers. Methods: In this study, a novel N-halamine precursor, 3-(3'-Chloro-propyl)-5,5-dimethylimidazolidine- 2,4-dione
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15

Baek, Ji-Yoon, Sam-Soo Kim, and Jae-Woong Lee. "Properties of Antimicrobial Membrane Using an N-Halamine Material." Textile Coloration and Finishing 21, no. 4 (2009): 57–62. http://dx.doi.org/10.5764/tcf.2009.21.4.057.

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16

Xuehong Ren, Changyun Zhu, Lei Kou, et al. "Acyclic N-Halamine Polymeric Biocidal Films." Journal of Bioactive and Compatible Polymers 25, no. 4 (2010): 392–405. http://dx.doi.org/10.1177/0883911510370387.

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17

Cerkez, Idris. "Rapid disinfection by N-halamine polyelectrolytes." Journal of Bioactive and Compatible Polymers 28, no. 1 (2013): 86–96. http://dx.doi.org/10.1177/0883911512470863.

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18

Eknoian, M. W., S. D. Worley, and J. M. Harris. "New Biocidal N-Halamine-PEG Polymers." Journal of Bioactive and Compatible Polymers 13, no. 2 (1998): 136–45. http://dx.doi.org/10.1177/088391159801300205.

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19

Cerkez, Idris, Hasan B. Kocer, S. D. Worley, R. M. Broughton, and T. S. Huang. "N-halamine copolymers for biocidal coatings." Reactive and Functional Polymers 72, no. 10 (2012): 673–79. http://dx.doi.org/10.1016/j.reactfunctpolym.2012.06.018.

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20

Li, Rong, Pei Hu, Xuehong Ren, S. D. Worley, and T. S. Huang. "Antimicrobial N-halamine modified chitosan films." Carbohydrate Polymers 92, no. 1 (2013): 534–39. http://dx.doi.org/10.1016/j.carbpol.2012.08.115.

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21

Dong, Qigeqi, Qian Cai, Yangyang Gao, et al. "Synthesis and bactericidal evaluation of imide N-halamine-loaded PMMA nanoparticles." New Journal of Chemistry 39, no. 3 (2015): 1783–91. http://dx.doi.org/10.1039/c4nj01806k.

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22

Wu, Kun, Jianqiao Li, Xin Chen, Jinrong Yao, and Zhengzhong Shao. "Synthesis of novel multi-hydroxyl N-halamine precursors based on barbituric acid and their applications in antibacterial poly(ethylene terephthalate) (PET) materials." Journal of Materials Chemistry B 8, no. 37 (2020): 8695–701. http://dx.doi.org/10.1039/d0tb01497d.

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23

Qiao, Mingyu, Tian Ren, Tung-Shi Huang, et al. "N-Halamine modified thermoplastic polyurethane with rechargeable antimicrobial function for food contact surface." RSC Advances 7, no. 3 (2017): 1233–40. http://dx.doi.org/10.1039/c6ra25502g.

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24

Sun, G., T. Y. Chen, W. Sun, W. B. Wheatley, and S. D. Worley. "Preparation of Novel Biocidal N-Halamine Polymers." Journal of Bioactive and Compatible Polymers 10, no. 2 (1995): 135–44. http://dx.doi.org/10.1177/088391159501000204.

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25

Elrod, D. B., and S. D. Worley. "Synthesis of Novel N-Halamine Biocidal Polymers." Journal of Bioactive and Compatible Polymers 14, no. 3 (1999): 258–69. http://dx.doi.org/10.1177/088391159901400305.

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26

Sun, Gang, Walter B. Wheatley, and S. Davis Worley. "A new cyclic N-halamine biocidal polymer." Industrial & Engineering Chemistry Research 33, no. 1 (1994): 168–70. http://dx.doi.org/10.1021/ie00025a022.

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27

Cerkez, Idris, Hasan B. Kocer, S. D. Worley, R. M. Broughton, and T. S. Huang. "Epoxide tethering of polymeric N-halamine moieties." Cellulose 19, no. 3 (2012): 959–66. http://dx.doi.org/10.1007/s10570-012-9699-z.

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28

Fei, Xin, Pengfei Gao, Takayuki Shibamoto, and Gang Sun. "Pesticide Detoxifying Functions of N-Halamine Fabrics." Archives of Environmental Contamination and Toxicology 51, no. 4 (2006): 509–14. http://dx.doi.org/10.1007/s00244-005-0175-8.

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29

Wang, Ru, Yuyao Li, Yang Si, et al. "Rechargeable polyamide-based N-halamine nanofibrous membranes for renewable, high-efficiency, and antibacterial respirators." Nanoscale Advances 1, no. 5 (2019): 1948–56. http://dx.doi.org/10.1039/c9na00103d.

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30

Li, Chenghao, Linyan Xue, Qian Cai, et al. "Design, synthesis and biocidal effect of novel amine N-halamine microspheres based on 2,2,6,6-tetramethyl-4-piperidinol as promising antibacterial agents." RSC Adv. 4, no. 88 (2014): 47853–64. http://dx.doi.org/10.1039/c4ra08443h.

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31

Kinali-Demirci, Selin. "Cross-Linked Polymer Brushes Containing N-Halamine Groups for Antibacterial Surface Applications." Polymers 13, no. 8 (2021): 1269. http://dx.doi.org/10.3390/polym13081269.

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Microbial contamination is a significant issue in various areas, especially in the food industry. In this study, to overcome microbial contamination, cross-linked polymer brushes containing N-halamine were synthesized, characterized, and investigated for antibacterial properties. The cross-linked polymer brushes with different N-halamine ratios were synthesized by in-situ cross-linking methods with reversible addition−fragmentation chain transfer (RAFT) polymerization using a bifunctional cross-linker. The RAFT agent was immobilized on an amine-terminated silicon wafer surface and utilized in
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32

MEDINA, GERARDO, HARSHITA CHAUDHARY, YANG QIU, et al. "Effectiveness of a Novel Rechargeable Polycationic N-Halamine Antibacterial Coating on Listeria monocytogenes Survival in Food Processing Environments." Journal of Food Protection 83, no. 11 (2020): 1974–82. http://dx.doi.org/10.4315/jfp-20-084.

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ABSTRACT The goal of this research was to evaluate the efficacy of a novel rechargeable nonleaching polycationic N-halamine coating applied to stainless steel food contact surfaces to reduce Listeria monocytogenes contamination on ready-to-eat (RTE) foods. Four L. monocytogenes strains were inoculated onto the charged (C; chlorine activated) or noncharged (NC) N-halamine–coated steel coupon surfaces that were either intact or scratched. After inoculation, test surfaces were incubated at 2, 10, and 25°C for 0, 48, and 72 h. L. monocytogenes transfer from coated adulterated surfaces to RTE meat
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33

Bu, Danlin, Na Li, Yu Zhou, et al. "Enhanced UV stability of N-halamine-immobilized Fe3O4@SiO2@TiO2 nanoparticles: synthesis, characteristics and antibacterial property." New Journal of Chemistry 44, no. 25 (2020): 10352–58. http://dx.doi.org/10.1039/d0nj01439g.

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34

Peng, Panpan, Jianjun Yang, Qingyun Wu, Mingyuan Wu, Jiuyi Liu, and Jianan Zhang. "Fabrication of N-halamine polyurethane films with excellent antibacterial properties." e-Polymers 21, no. 1 (2021): 047–56. http://dx.doi.org/10.1515/epoly-2021-0007.

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Abstract An N-halamine precursor, namely, 2-amino-5-(2-hydroxyethyl)-6-methylpyrimidin-4-one (AHM), was used as a chain extender in the preparation of a series of N-halamine polyurethane (PU) films, in order to also instill antibacterial properties. The mechanical properties, thermodynamic performance, and antimicrobial performance of the functionalized PU films were systematically studied. The results showed that the addition of AHM could improve the thermodynamic and mechanical properties of the developed PU films. Conducting tests in the presence of Escherichia coli and Staphylococcus aureu
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35

Bastarrachea, Luis J., and Julie M. Goddard. "Development of antimicrobial stainless steel via surface modification with N-halamines: Characterization of surface chemistry and N-halamine chlorination." Journal of Applied Polymer Science 127, no. 1 (2012): 821–31. http://dx.doi.org/10.1002/app.37806.

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36

Li, Leixuan, Yan Xin, Fengze Wu, et al. "A Polysiloxane Delivery Vehicle of Cyclic N-Halamine for Biocidal Coating of Cellulose in Supercritical CO2." Polymers 14, no. 23 (2022): 5080. http://dx.doi.org/10.3390/polym14235080.

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Cyclic N-halamines are highly antimicrobial, very stable, and not susceptible to bacterial resistance. A polysiloxane delivery vehicle was synthesized to deliver cyclic imide N-halamine onto cellulose via a benign and universal procedure that does not require a harmful solvent or chemical bonding. In brief, Knoevenagel condensation between barbituric acid and 4-hydroxybenzaldehyde furnished 5-(4-hydroxybenzylidene)pyrimidine-2,4,6-trione, whose phenolic O−H was subsequently reacted with the Si−H of poly(methylhydrosiloxane) (PMHS) via silane alcoholysis. The product of silane alcoholysis was i
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37

Chien, Hsiu-Wen, Ying-Yuan Chen, Yen-Lun Chen, Chi-Hui Cheng, and Jui-Che Lin. "Studies of PET nonwovens modified by novel antimicrobials configured with both N-halamine and dual quaternary ammonium with different alkyl chain length." RSC Advances 9, no. 13 (2019): 7257–65. http://dx.doi.org/10.1039/c9ra00094a.

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This work describes the synthesis of novel antimicrobial agents consisting of N-halamine and dual quaternary ammonium with different alkyl chain lengths and their antimicrobial applications for PET nonwovens.
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38

Akdag, Akin, Jie Liang, and S. D. Worley. "Oxidation of Organic Sulfides by N-Halamine Compounds." Phosphorus, Sulfur, and Silicon and the Related Elements 182, no. 7 (2007): 1525–33. http://dx.doi.org/10.1080/10426500701247102.

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39

Kocer, Hasan B., Idris Cerkez, S. D. Worley, R. M. Broughton, and T. S. Huang. "N-Halamine Copolymers for Use in Antimicrobial Paints." ACS Applied Materials & Interfaces 3, no. 8 (2011): 3189–94. http://dx.doi.org/10.1021/am200684u.

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40

Sun, Gang, Leslie C. Allen, E. Paige Luckie, Walter B. Wheatley, and S. Davis Worley. "Disinfection of Water by N-Halamine Biocidal Polymers." Industrial & Engineering Chemistry Research 34, no. 11 (1995): 4106–9. http://dx.doi.org/10.1021/ie00038a054.

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41

Worley, S. D., D. E. Williams, and S. B. Barnela. "The stabilities of new n-halamine water disinfectants." Water Research 21, no. 8 (1987): 983–88. http://dx.doi.org/10.1016/s0043-1354(87)80017-9.

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42

Williams, JF, J. Suess, J. Santiago, et al. "Antimicrobial properties of novel n-halamine siloxane coatings." Surface Coatings International Part B: Coatings Transactions 88, no. 1 (2005): 35–39. http://dx.doi.org/10.1007/bf02699705.

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43

Jie, Zhiqiang, Bing Zhang, Lianhong Zhao, Xiufang Yan, and Jie Liang. "Regenerable antimicrobial silica gel with quaternarized N-halamine." Journal of Materials Science 49, no. 9 (2014): 3391–99. http://dx.doi.org/10.1007/s10853-014-8048-z.

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44

Kocer, Hasan B. "Residual disinfection with N-halamine based antimicrobial paints." Progress in Organic Coatings 74, no. 1 (2012): 100–105. http://dx.doi.org/10.1016/j.porgcoat.2011.11.022.

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45

Li, Xiaolin, Ying Liu, Yin Liu, et al. "Biocidal Activity of N-Halamine Methylenebisacrylamide Grafted Cotton." Journal of Engineered Fibers and Fabrics 10, no. 2 (2015): 155892501501000. http://dx.doi.org/10.1177/155892501501000217.

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Methylenebisacrylamide (MBA) was coated on cotton fabric via free radical polymerization with the aid of initiator. The surface of grafted fabric was characterized by FTIR and SEM, which confirmed that MBA was grafted onto cotton cellulose via covalent bonding. Exposure to dilute sodium hypochlorite solution was found to render the grafted fabric biocidal. The chlorinated cotton was found to inactivate 99.97% of Staphylococcus aureus and 99.99% of Escherichia coli O157:H7 within 30 min of contact time, respectively. The washing stability and UV irradiation recharge ability of coated fabric wer
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46

Ma, Wei, Lin Li, Jing Li, Xuehong Ren, Zhi-Guo Gu, and Tung-Shi Huang. "Antibacterial PVA membranes containing TiO2 /N-halamine nanoparticles." Advances in Polymer Technology 37, no. 5 (2017): 1390–400. http://dx.doi.org/10.1002/adv.21798.

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47

Ahmed, Abd El-Shafey I., Hamdi M. H. Gad, and John N. Hay. "Sand/charcoal N -halamine blends for water treatment." Polymer Composites 35, no. 11 (2014): 2137–43. http://dx.doi.org/10.1002/pc.22876.

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48

Fan, Xiaoyan, Xuehong Ren, Tung-Shi Huang, and Yuyu Sun. "Cytocompatible antibacterial fibrous membranes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and quaternarized N-halamine polymer." RSC Advances 6, no. 48 (2016): 42600–42610. http://dx.doi.org/10.1039/c6ra08465f.

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A novel polymeric N-halamine-containing quaternary ammonium salt (PHQS) was synthesized and used to make antibacterial electrospun fibrous membranes by blending with biodegradable poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-4HB)).
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49

Liu, Ying, Jing Li, Xiaoli Cheng, Xuehong Ren, and T. S. Huang. "Self-assembled antibacterial coating by N-halamine polyelectrolytes on a cellulose substrate." Journal of Materials Chemistry B 3, no. 7 (2015): 1446–54. http://dx.doi.org/10.1039/c4tb01699h.

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In this research, two N-halamine polymer precursors, a cationic homopolymer poly((3-acrylamidopropyl)trimethylammonium chloride) (CHP) and an anionic homopolymer poly(2-acrylamido-2-methylpropane sulfonic acid sodium salt) (AHP), have been successfully synthesized and coated onto cotton fabrics via a layer-by-layer (LbL) deposition technique.
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50

Wang, Yingfeng, Lin Li, Ying Liu, Xuehong Ren, and Jie Liang. "Antibacterial mesoporous molecular sieves modified with polymeric N-halamine." Materials Science and Engineering: C 69 (December 2016): 1075–80. http://dx.doi.org/10.1016/j.msec.2016.08.017.

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