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1

ALBUQUERQUE, Diego Araújo Pessoa de. "Perfil Proteômico e Imunômico da Lectina Ligadora de Manose (Mbl) em Indivíduos Portadores do Vírus da Hepatite." Universidade Federal de Pernambuco, 2010. https://repositorio.ufpe.br/handle/123456789/1811.

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Made available in DSpace on 2014-06-12T15:52:33Z (GMT). No. of bitstreams: 2 arquivo415_1.pdf: 1541390 bytes, checksum: 2ab8d4738aeb89e4edfdfacd804ccf72 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2010<br>Faculdade de Amparo à Ciência e Tecnologia do Estado de Pernambuco<br>A lectina ligadora de manose (mannan binding lectin - MBL) é membro das glicoproteínas plasmáticas, um grupo de proteínas que se caracteriza pela interação com um ou mais resíduos de açúcares específicos expressos em vários sistemas biológicos. Concentrações re
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Wood, Christopher Andrew 1973. "Microstructural development and control of ceramics in the Ca-Si-Al-O-N system." Monash University, School of Physics and Materials Engineering, 2001. http://arrow.monash.edu.au/hdl/1959.1/8263.

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Ciccotosto, Silvana. "The preparation and evaluation of N-acetylneuraminic acid derivatives as probes of sialic acid-recognizing proteins." Monash University, Dept. of Medicinal Chemistry, 2004. http://arrow.monash.edu.au/hdl/1959.1/9649.

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4

Song, Weifeng. "Cobalt- and Nickel-Catalyzed Functionalization of Unactivated C–Hal, C–O and C–H Bonds." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://hdl.handle.net/11858/00-1735-0000-0001-BC70-0.

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Chintapakorn, Yupynn 1960. "An antisense approach to study the roles of arginine decarboxylase and putrescine N-methyltransferase in alkaloid metabolism in Nicotiana tabacum L." Monash University, Dept. of Biological Sciences, 2002. http://arrow.monash.edu.au/hdl/1959.1/7622.

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MIZUOCHI, TSUGUO, MUNEHIRO NAKATA, IRVING BOIME та ін. "Alteration of N-linked oligosaccharide structures of human chorionic gonadotropin β -subunit by disruption of disulfide bonds". Thesis, Springer, 1997. http://hdl.handle.net/2237/16683.

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Gaiotti, Sebastiano <1993&gt. "Modeling and analysis of the (H2C2)n(HCN)m gas-phase clusters by ab initio and DFT computational methods for astrochemical applications." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/20099.

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Among the different purposes of astrochemistry, there is the study of chemical processes in the Interstellar Medium (ISM), and the corresponding reaction pathways that may lead to the formation of biological molecules. Within this framework, in recent years some gas-phase clusters have been investigated since they may constitute the first steps involved in these reaction networks. The study presented in this thesis aims to illustrate different types of clusters involving hydrogen cyanide and acetylene, such molecules present a lot of interesting interactions including Van der Waals and dispers
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Urban, Joachim. "Messungen der stratosphärischen Spurengase CIO, HCI, O 3, N 2 O, H 2 O und OH mittels flugzeuggetragener Submillimeterwellen-Radiometrie bei 650 und 2500 GHz = Measurements of the stratospheric trace gases CIO, HCI, O 3, N 2 O, H 2 O and OH using airborne submm-wave radiometry at 650 and 2500 GHz /." Bremerhaven : Alfred-Wegener-Institut (AWI) für Polar- und Meeresforschung, 1998. http://www.gbv.de/dms/bs/toc/242415342.pdf.

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Madumadu, Glynn George. "Inheritance of resistance to Corynebacterium michiganense (E.F. Sm.) H.L. Jens in tomato (Lycopersicon esculentum) and effect of host nutrition (N and CA) on resistance /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259580261617.

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Silva, AiÃrta Cristina Carrà da. "Study of Lippia alba (Mill.) N. E. Brown species and endophytic fungi associated with emphasis on the study of VOCs and biotransformations." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17018.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>This work aimed to isolate and identify endophytic fungi associated to three chemotypes of Lippia alba (Mill.) NE Brown found in Brazilian Northeast and investigate the potential of these fungi in the production of volatile organic compounds (VOCs) and in front biotransformation to organic substrates. In addition, there was a comparative study of the chemical composition of the leaves three chemotypes of L. alba detected both in essential oils obtained by hydrodistillation as the volatile constituents obtained by solid phase microex
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Silva, Rodrigo Duarte. "Síntese de nanocompósitos poliméricos de poli(acrilato de n-butila-co-metacrilato de metila) P(BA-co-MMA) e Hidróxidos Duplos Lamelares (HDL) por meio da técnica de polimerização em miniemulsão." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/266790.

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Orientador: Liliane Maria Ferrareso Lona<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Química<br>Made available in DSpace on 2018-08-19T09:07:05Z (GMT). No. of bitstreams: 1 Silva_RodrigoDuarte_M.pdf: 10171342 bytes, checksum: d8c5c116297d9e1edee32a935dfb816c (MD5) Previous issue date: 2011<br>Resumo: O objetivo deste trabalho foi sintetizar nanocompósitos poliméricos (NCPs) contendo Hidróxidos Duplos Lamelares (HDLs) por meio da técnica de polimerização em miniemulsão. O copolímero poli(acrilato de n-butila-co-metacrilato de metila) P(BA-co- MMA) fo
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REGHELLIN, VERONICA. "Studies on the mechanism of action of antiviral agents targeting the replication complex of hepatitis c virus." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/52708.

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At the moment, several companies are studying the clinical potential of different all-oral combinations of direct-acting antivirals in ongoing studies. The most promising interferon-free combination therapies that are on the horizon include linear or cyclic NS3/4A protease inhibitors, nucleoside as well as non-nucleoside NS5B polymerase inhibitors , and NS5A inhibitors. DAAs that target NS3/4A (protease) and NS5B (RNA-dependent RNA polymerase) inhibit the enzymatic activity of these proteins. NS5A replication complex inhibitors will likely form a component of future interferon-free dru
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13

Price, Erin Peta. "Development of novel combinatorial methods for genotyping the common foodborne pathogen Campylobacter jejuni." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16601/1/Erin_Peta_Price_Thesis.pdf.

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Campylobacter jejuni is the commonest cause of bacterial foodborne gastroenteritis in industrialised countries. Despite its significance, it remains unclear how C. jejuni is disseminated in the environment, whether particular strains are more pathogenic than others, and by what routes this bacterium is transmitted to humans. One major factor hampering this knowledge is the lack of a standardised method for fingerprinting C. jejuni. Therefore, the overall aim of this project was to develop systematic and novel genotyping methods for C. jejuni. Chapter Three describes the use of single nucleo
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Price, Erin Peta. "Development of novel combinatorial methods for genotyping the common foodborne pathogen Campylobacter jejuni." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16601/.

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Campylobacter jejuni is the commonest cause of bacterial foodborne gastroenteritis in industrialised countries. Despite its significance, it remains unclear how C. jejuni is disseminated in the environment, whether particular strains are more pathogenic than others, and by what routes this bacterium is transmitted to humans. One major factor hampering this knowledge is the lack of a standardised method for fingerprinting C. jejuni. Therefore, the overall aim of this project was to develop systematic and novel genotyping methods for C. jejuni. Chapter Three describes the use of single nucleo
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Labeau, Athena. "Identification and characterization of cellular factors required for zika virus and dengue virus infection." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7060.

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Les virus de la Dengue (DENV) et Zika (ZIKV) sont deux virus émergents transmis par des moustiques et sont responsables de pathologies sévères chez l’homme. Il n’y a actuellement aucun vaccin efficace, ni traitements antiviraux disponibles contre ces arbovirus. DENV et ZIKV sont des parasites intracellulaires obligatoires qui dépendent entièrement de leur cellule hôte pour se multiplier. Cette dépendance constitue un potentiel talon d’Achille qui pourrait être exploité dans le développement de nouvelles stratégies thérapeutiques. L’objectif général de mon travail de thèse a été de comprendre a
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Wilkinson, Brendan Luke. "Synthesis of Novel Carbohydrate Based Enzyme Inhibitor Libraries Utilising Click Chemistry." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/366473.

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Within a short timeframe, the CuI-catalysed 1,3-dipolar cycloaddition (1,3-DCR) of an organic azide to a terminal acetylene to form a 1,4-disubstituted-1,2,3-triazole, has emerged as a powerful synthetic transformation in combinatorial chemistry, organic synthesis and bioconjugation research. This synthetic methodology, now known as click chemistry, has had an appreciable impact in the drug discovery and biotechnology sectors and has shown broad scope and compatibility with small molecule and polymeric substrates. The application of this powerful synthetic transformation, specifically in carbo
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Hwang, Shu-Yu, and 黃舒瑜. "Study of the Correlation between 0.1 N HCl Extraction and Total Concentration of Heavy Metals in the Soils." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/63407844976130747048.

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碩士<br>逢甲大學<br>環境工程與科學所<br>91<br>In the natural metals circulatory system, soil is an important medium and supplies the nutrients which are indispensable to creature. Moreover, it is the last place where pollutants accumulate. Due to the development of economy and society, more and more chemical matters enter into soil in abnormal ways. Facing increasingly acute problem of soil pollution, many countries give an impetus to the investigation and prevention of soil pollution. In order to protect precious soil resources, the Environmental Protection Administration of R.O.C. promulgated “Soil and Gr
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HUANG, SHEN-KAI, and 黃聖凱. "Inhibition of HCV Replication by N-terminal NS5A Protein." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/92dayz.

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碩士<br>慈濟大學<br>醫學生物技術碩士班<br>104<br>Hepatitis C virus (HCV) NS5A protein could be cleaved at residue 154 under certain circumstances, e.g., apoptosis. NS5A without its N-terminal 154 amino acid possesses transcriptional activity. The function of the N-terminal 154 a.a. of NS5A (NS5A 1-154) is unknown. Over-expressed NS5A could enhance HCV replication while NS5A 1-154 would repress viral replication in the replicon system. Exosomes, nano-particles (30 -100 nm diameter) derived from cells, are formed by the inward budding of the multivesicular body (MVB) membrane. It is reported that exosomes cou
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Lin, Shu-Hsuan, and 林書玄. "Overexpression, Purification and Characterization of the HCV Core Protein N-terminus." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/68016700069262168510.

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碩士<br>國立陽明大學<br>生物化學研究所<br>93<br>The hepatitis c virus core protein is the major component of hepatitis c virus nucleocapsid and also exhibits multiple functions involving in cellular growth, proliferation and other functions. In this study, we successfully established the core protein overexpression system in E. coli. using pQE and pET vector. Our result indicated that the core protein 1-116 without the hydrophobic C-terminal domain is the best expression construct. We succeeded in purifying the large-scale core protein for full length and several C-terminal truncated core proteins including
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Nahler, Nils Hendrik. "Photodissoziation von Halogenwasserstoff- und orientierten Wasserstoff-Edelgas-Halogen-Molekülen in Clusterumgebungen." Doctoral thesis, 2002. http://hdl.handle.net/11858/00-1735-0000-0006-B431-7.

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Čeganová, Markéta. "Ovlivnění plazmatické hladiny cholesterolu modelového organizmu polynenasycenými mastnými kyselinami n-3." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-179311.

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The aim of this thesis is to assess the influence of the polyunsaturated fatty acids, especially DHA and EPA in the diet on the animal organism in accordance to the levels of total HDL and LDL cholesterol and triglycerides in plasma. As experimental animals were used rats and they were divided into 3 groups of 10 pieces: control group with the addition of 6 % Carthamus tinctorius (n-6 flares), the group with the addition of 6 % fish oil (n-3: EPA, DHA fish) and the group with 6 % addition of oil from Schizochytrium (n-3: DHA, DHA). After 40 days the animals were putted to death according to re
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Huang, Po-Hua, and 黃柏樺. "The Phase Transition and Corrosion Resistance of N-doped ZrO2 Thin Films Deposited by HCD-IP." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/10140402962895130015.

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碩士<br>國立清華大學<br>工程與系統科學系<br>99<br>N-doped ZrO2 thin films were deposited respectively on Si (Si-series) and 304 stainless steel (SS-series) substrates using hallow cathode discharge ion-planting (HCD-IP). The objectives of the present study were to understand the effect of substrate materials on phase transition and to provide a feasible approach to manufacture N-doped ZrO2 coatings with excellent corrosion resistance and good adhesion. By maintaining oxygen flow rate at 10 sccm and adjusting nitrogen flow rate, ranging from 0 to 12 sccm, the compositions and phase ratios of the N-doped ZrO2
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Chen, Po-Chang, and 陳柏樟. "Role of N-Linked Glycans in the interactions of the HCV envelope glycoproteins with cellular receptors." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/07656504992266461685.

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博士<br>國立臺灣大學<br>生化科學研究所<br>101<br>Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis and hepatocellular carcinoma worldwide. It infects human liver cells through interacting with several cellular protein receptors including CD81, SR-BI, Claudin-1 and occludin. There are accumulating reports indicating that lectin receptors can mediate HCV recognition and entry in the body. The envelope proteins of HCV (E1 and E2) are heavily glycosylated, further address the role of lectin receptor-viral particle interaction in HCV infection. However, there is limited report investigating
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Tsai, Chieh Feng, and 蔡傑峰. "Synthesis, Structural Characterization of Dinuclear metal complex,[Ni2L2](H2L = N-(6-(1,8-naphthyridin-7-ylamino)pyridin-2-yl)acetamide)." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/224cd5.

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碩士<br>國立臺灣大學<br>化學研究所<br>105<br>The aim of this research is to study the synthesis, structure and properties of the dinuclear nickel complexes which the ligand is N-(6-(1,8-naphthyridin-7-ylamino)pyridin-2-yl) acetamide. The novel asymmetrical ligand was synthesized by palladium-catalyzed reaction which was proposed by S. L. Buchwald , and the product was characterized by NMR and FAB-MS. First of all, we reacted this ligand with Ni(OAc)2∙ 4H2O at high temperature of melt naphthalene, we successfully obtaines one dinuclear compound, [Ni2L2]. The X-ray structure studies of [Ni2L2] reveals the
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Aryadeep, Chirag, and Chirag Aryadeep. "A Study of P and N-Doping in the Thick Gate of a 100V UMOS Device for HCI Improvement." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/69426546531632427055.

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碩士<br>亞洲大學<br>資訊工程學系<br>105<br>The UMOS field effect transistor or UMOSFET is a form of vertical or “trench” style structure used for MOS transistors. This form of semiconductor “trench” or vertical semiconductor technology offers significant advantages in term of speed and lowering the ON resistance. As a result, many manufacturers of semiconductor electronics components offer a vertical form of structure for their transistor. The UMOSFETs are able to provide a useful function in many relatively high-power applications, both in power supplies and RF power transistors. Trench MOS devices offe
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Vieira, Hugo David Jesus. "Touch ‘n’ sketch: pen and fingers on a multi-touch sketch application for tablet PC’s." Master's thesis, 2011. http://hdl.handle.net/10400.13/322.

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In many creative and technical areas, professionals make use of paper sketches for developing and expressing concepts and models. Paper offers an almost constraint free environment where they have as much freedom to express themselves as they need. However, paper does have some disadvantages, such as size and not being able to manipulate the content (other than remove it or scratch it), which can be overcome by creating systems that can offer the same freedom people have from paper but none of the disadvantages and limitations. Only in recent years has the technology become massively availabl
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陳維家. "Theoretical Studies of the Following Reaction Mechanisms:I.The C-N Coupling Reaction on Pt(111) and Ni(111) Surface II.the HCN Formation from CHxNO on Pt(111) surface." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/52966892223090960757.

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碩士<br>國立臺灣師範大學<br>化學系<br>99<br>I: The C-N Coupling Reaction on Pt(111) and Ni(111) Surface. We used the density functional theory (DFT) with the projector-augmented-wave method (PAW) to systematically investigate the C-N coupling reaction, an important catalytic process in industrial synthesis to form hydrogen cyanide (HCN), on Pt(111) and Ni(111)surface. This reaction includes several steps, such as the adsorption of reactants and products (CHx, NHy and CHxNHy x=0-3 y=0-2), dehydrogenation of methane and ammonia, movement of molecular fragments on the surface, and C-N coupling processes. Fr
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Manoharan, Simna. "Engineering the N-Glycosylation Pathway in Pichia Pastoris for the Expression of Glycoprotein Hormones." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3017.

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Proteins, participating in a myriad of biological function, are at the core of all cellular activities occurring within living organisms. Therapeutic proteins, hence constitute a major part of the pharmaceutical industry. The glycoprotein hormones follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH) and human chorionic gonadotropin (CG) regulate various reproductive and metabolic functions in humans and hence have high therapeutic potentials. The increasing demand of recombinant proteins for therapeutic uses drives the development of better expressio
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Manoharan, Simna. "Engineering the N-Glycosylation Pathway in Pichia Pastoris for the Expression of Glycoprotein Hormones." Thesis, 2016. http://hdl.handle.net/2005/3017.

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Proteins, participating in a myriad of biological function, are at the core of all cellular activities occurring within living organisms. Therapeutic proteins, hence constitute a major part of the pharmaceutical industry. The glycoprotein hormones follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH) and human chorionic gonadotropin (CG) regulate various reproductive and metabolic functions in humans and hence have high therapeutic potentials. The increasing demand of recombinant proteins for therapeutic uses drives the development of better expressio
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Kashyap, Srishti. "Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4135.

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Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that cancer will become the leading cause of death in the coming years. The medical treatment of cancer still has many unmet needs. The main curative therapies for cancer, surgery and radiation, are generally only successful if the cancer is found at an early localized stage. Once cancer has progressed to metastatic stage, these therapies are less successful. Hence, chemotherapeuti
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