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Dissertations / Theses on the topic 'N-methyltransferase'

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Published: 4 June 2021

Last updated: 3 February 2022

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1

Zamiri, Maryam. "Synthesis of protein arginine N-methyltransferase 6 inhibitors." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43808.

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Protein arginine N-methyltransferases (PRMTs) are pertinent targets for drug discovery as their dysfunction is associated with a number of diseases such as cancers, cardiovascular diseases and viral pathogenesis. The precise role of PRMTs in the initiation, development, or progression of diseases is not known yet. Due to association of PRMT1 and 4 with transcriptional activation, the main focus of inhibitor discovery has been on these two enzymes. On the other hand, the goal of this study is to find a PRMT6 specific inhibitor. PRMT6 methylates DNA polymerase β, histones H3 and H4 and HIV pr

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2

Pak, Laam. "Insights into a heteromeric protein arginine N-methyltransferase complex." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42123.

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Protein arginine N-methyltransferases (PRMTs) act in signaling pathways and gene expression by methylating arginine residues within target proteins. PRMT1 is responsible for most cellular arginine methylation activity and can work independently or in collaboration with other PRMTs. In this Ph.D. thesis I demonstrated an interaction between PRMT1 and -2 using co-immunoprecipitation and bimolecular fluorescence complementation (BiFC). As a result of this interaction, PRMT2 stimulated PRMT1 methyltransferase activity, affecting its apparent Vmax and Km values in vitro, and increasing the producti

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3

Thomas, Martin Geoffrey. "The role of nicotinamide N-methyltransferase in Parkinson's disease." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-nicotinamide-nmethyltransferase-in-parkinsons-disease(b4711b58-9f3d-458f-a7a1-c7f15d658a86).html.

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Parkinson’s disease (PD) is a progressive neurological movement disorder characterised by degenerating dopaminergic neurons in the midbrain’s substantia nigra pars compacta (SNpc). In the majority of cases, PD is thought to be caused by a plethora of overlapping factors that combine to cause toxicity in SNpc neurons. The enzyme nicotinamide N-methyltransferase (NNMT) is expressed at higher levels in the brain of PD patients. However, whether this association is indicative of a causative role in PD is unclear. The biochemical effects of NNMT expression were determined by comparing the NNMT-V5 e

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4

Ridgway, Neale David. "Rat hepatic phosphatidylethanolamine N-methyltransferase : enzyme purification and characterization." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29377.

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Phosphatidylethanolamine (PE) N-methyltransferase catalyzes the stepwise transfer of methyl groups from S-adenosyl-L-methionine (AdoMet) to the amino headgroup of PE. Successive methylation results in the formation of the two intermediates, phosphatidyl-N-monomethylethanolamine (PMME) and phosphatidyl-N, N-dimethylethanolamine (PDME), and the final product phosphatidylcholine (PC). PE N-methyltransferase is an integral membrane protein localized primarily in the endoplasmic reticulum (microsomal fraction) of liver. PE-, PMME- and PDME-dependent PE N-methyltransferase activities were purified f

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5

Copin, Nane. "Catecholamine synthesising enzymes in the programming of hypertension by mild protein restriction during gestation." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268370.

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6

Rao, Anoop 1977. "Transcriptional response of O⁶-methylguanine methyltransferase deficient yeast to methyl-N-nitro-N-nitrosoguanidine (MNNG)." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28304.

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Thesis (S.M.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.<br>Includes bibliographical references (leaves 66-75).<br>(cont.) of transcription factors and subsequently, induction of RNA processing (35% of genes incrementally induced) and kinases involved in protein phosphorylation. In the WT, the response was restricted to a transient repression of fundamental biochemical processes. Interestingly, a gene whose repression is known to mimic apoptosis was found to be repressed in the WT. The overwhelming induction of ribosomal protein synthesis genes in both WT an

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7

Kim, Hyejeong. "Characterization of the N-terminal region of tRNA m1G9 methyltransferase (Trm10)." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1372619914.

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8

Mao, Yunfei. "Substrate Recognition and Mechanistic Studies of Protein N-Terminal Methyltransferase 1." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4414.

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The methylation at the α-N-terminal amines of proteins that start with a canonical motif X-P-K (X=A/P/S) has been a known modification for nearly four decades. In 2010, protein α-N-terminal methyltransferase 1 (NTMT1/NRMT1) was identified as the first enzyme responsible for this modification. NTMT2 was discovered as a second member belonging to this family, but it was reported as a mono-methylase. The identification of RCC1, retinoblastoma (Rb) protein, centromere protein-A/B (CENP-A/B), and DNA damaged-binding protein 2 (DDB2) as new NTMT1 substrates revealed NTMT1’s biological significance i

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9

Oldenburg, Susan [Verfasser]. "Untersuchungen zur Expression der Nicotinamid N-Methyltransferase im klarzelligen Nierenzellkarzinom / Susan Oldenburg." Greifswald : Universitätsbibliothek Greifswald, 2011. http://d-nb.info/1016668562/34.

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10

Choi, Kum-boo. "Biochemical and molecular analyses of coclaurine N-methyltransferase from cultured Coptis japonica cells." Kyoto University, 2001. http://hdl.handle.net/2433/150351.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第9213号<br>農博第1218号<br>新制||農||834(附属図書館)<br>学位論文||H13||N3597(農学部図書室)<br>UT51-2001-R762<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授佐藤文彦, 教授關谷次郎, 教授大山莞爾<br>学位規則第4条第1項該当

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11

Ottaviani, Silvia. "The role of glycine N-methyltransferase in the androgen-mediated development of prostate cancer." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39404.

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Prostate cancer is the most frequently diagnosed malignancy among men in the Western world. The development and growth of prostate cancer is dependent upon androgens, whose effects are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily of ligand-activated transcription factors. The identification of androgen-regulated genes in prostate cancer cells, particularly those involved in cell growth, cell survival and cell migration are, therefore, of great importance for defining the mechanisms of prostate cancer development and progression, and thus developing new m

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12

Williams, Monique J. "Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of Î±-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis." Doctoral thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/14800.

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Includes bibliographical references (leaves 120-133).<br>Ergothioneine and mycothiol are the two major low molecular weight thiols present in mycobacteria. The generation of mycothiol-deficient mutants has demonstrated its role in protecting M tuberculosis against oxidative and nitrosative stress. To date, no ergothioneine-deficient mutants have been identified and the role of ergothioneine in mycobacteria remains unknown. The work in this thesis was performed with the aim of better understanding the function of ergothioneine in mycobacteria, by studying its biosynthesis and the conditions aff

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13

Katti, Christiana. "Characterization of the S-adenosyl-L-methionine binding subunit of the mRNA (N⁶-adenosine) methyltransferase /." View abstract, 2005. http://wwwlib.umi.com/dissertations/fullcit/3205449.

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14

Kraus, Nils Arne [Verfasser], Christoph [Gutachter] Wanner, and Daniel [Gutachter] Zeller. "Modulation der Fettzellfunktion durch die Nicotinamid-N-Methyltransferase / Nils Arne Kraus ; Gutachter: Christoph Wanner, Daniel Zeller." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1211959783/34.

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15

Sachan, Nita. "IDENTIFICATION OF SIGNALING FACTORS INVOLVED IN THE REGULATION OF ALKALOID METABOLISM IN N. TABACUM." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_diss/442.

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To identify the signaling mechanisms and components that are involved in regulation of a promoter for a gene involved in a secondary pathway I studied the nicotinic alkaloid biosynthetic pathway using various N. tabacum tissues. Nicotine and tropane alkaloids are widely known to be synthesized predominantly in the roots of species that produce pyrrolinium ring containing alkaloids. Putrescine Nmethyltransferase (PMT) catalyzes the first committed step in the biosynthesis of these alkaloid secondary products and earlier studies have indicated that PMT gene expression is restricted to root tissu

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16

Grönberg, Naima. "Induction of pathogenesis-related genes, PR-17a and N-methyltransferase, in barley infested by the aphid Rhopalosiphum padi." Thesis, Södertörn University College, School of Life Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-656.

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<p>Plants produce a large diverse array of organic compounds that may function in protection against pathogens. Diverse antifungal compounds were reported to exist in barley (Hordeum vulgare L.); the indole alkaloid, gramine, and the pathogenesis-related proteins are some of them. Both the N-methyltransferase that is involved in gramine biosynthesis and PR-17a were studied in barley upon infestation by the bird cherry-oat aphid (Rhopalosiphum padi).</p><p>The effect of infestation by R. padi on induction of PR-17a and N-methyltransferase was investigated in different barley lines, susceptible

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17

Holstein, Sina [Verfasser], Reinhard [Akademischer Betreuer] Walther, Reinhard [Gutachter] Walther, and Susanne [Gutachter] Füssel. "Charakterisierung der Nikotinamid-N-Methyltransferase im klarzelligen Nierenzellkarzinom / Sina Holstein ; Gutachter: Reinhard Walther, Susanne Füssel ; Betreuer: Reinhard Walther." Greifswald : Universität Greifswald, 2020. http://d-nb.info/1216996709/34.

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18

Holstein, Sina [Verfasser], Reinhard Akademischer Betreuer] Walther, Reinhard [Gutachter] Walther, and Susanne [Gutachter] [Füssel. "Charakterisierung der Nikotinamid-N-Methyltransferase im klarzelligen Nierenzellkarzinom / Sina Holstein ; Gutachter: Reinhard Walther, Susanne Füssel ; Betreuer: Reinhard Walther." Greifswald : Universität Greifswald, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-39217.

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19

Ehebauer, Franziska [Verfasser], Daniel [Gutachter] Kraus, Heike [Gutachter] Hermanns, Christoph [Gutachter] Wanner, and Matthias [Gutachter] Kroiß. "Regulation of Nicotinamide N-methyltransferase Expression in Adipocytes / Franziska Ehebauer ; Gutachter: Daniel Kraus, Heike Hermanns, Christoph Wanner, Matthias Kroiß." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1223373312/34.

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20

Kshetri, Man B. "N-TERMINAL DOMAIN OF rRNA METHYLTRANSFERASE ENZYME RsmC IS IMPORTANT FOR ITS BINDING TO RNA AND RNA CHAPERON ACTIVITY." Kent State University Honors College / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1621007414429417.

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21

Chintapakorn, Yupynn 1960. "An antisense approach to study the roles of arginine decarboxylase and putrescine N-methyltransferase in alkaloid metabolism in Nicotiana tabacum L." Monash University, Dept. of Biological Sciences, 2002. http://arrow.monash.edu.au/hdl/1959.1/7622.

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22

Huang, Chih-Hua. "Peroxisome proliferator-activated receptor gamma inhibits cell growth and negatively regulates DNA methyltransferase promoter activity in SK-N-AS neuroblastoma cells." Thesis, University of Southampton, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560565.

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Neuroblastoma is the most common extra-cranial childhood solid tumour which arises from embryonic neural crest cells that fail to undergo a differentiation programme to form mature sympathetic neurones. Most children with advanced stage neuroblastoma have a 5-year event free survival rate of only 20%. However, the spontaneous differentiation of some early stage neuroblastoma into non-malignant gangliomas has prompted the search for agents that can induce neuroblastoma differentiation. Peroxisome proliferator-activated receptor gamma (PPARƴ) is a member of the nuclear receptor superfamily of li

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23

Rodriguez, Flores Juan Lorenzo. "In silico, in vitro, in vivo and in populo regulatory genetics of single nucleotide polymorphisms in the phenylethanolamine N-methyltransferase promoter /." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3356146.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 15, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 72-75).

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24

Dacwag, Caroline S. "Analysis of Protein Arginine Methyltransferase Function during Myogenic Gene Transcription: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/402.

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Skeletal muscle differentiation requires synergy between tissue-specific transcription factors, chromatin remodeling enzymes and the general transcription machinery. Here we demonstrate that two distinct protein arginine methyltransferases are required to complete the differentiation program. Prmt5 is a type II methyltransferase, symmetrically dimethylates histones H3 and H4 and has been shown to play a role in transcriptional repression. An additional member of the Prmt family, Carm1 is a type I methyltransferase, and asymmetrically methylates histone H3 and its substrate proteins. MyoD regul

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25

Biastoff, Stefan [Verfasser], Birgit [Akademischer Betreuer] Dräger, Maike [Akademischer Betreuer] Petersen, and Ludger [Akademischer Betreuer] Wessjohann. "Untersuchung zur strukturellen Verwandtschaft von Putrescin N-methyltransferase und Spermidinsynthase 1 aus Datura stramonium L. / Stefan Biastoff. Betreuer: Birgit Dräger ; Maike Petersen ; Ludger Wessjohann." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2010. http://d-nb.info/1024937941/34.

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26

Friese, Ryan Scott. "Evidence for a genetic mechanism of the chromogranin A and phenylethanolamine-N-methyltransferase genes in the pathogenesis of hypertension in the spontaneously hypertensive rat." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3258713.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed June 8, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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27

Grombacher, Thomas [Verfasser]. "Reparatur von Methylierungsschäden der DNA: Konstitutive Expression und Induzierbarkeit der O⁶-Methylguanin-DNA-Methyltransferase und der N-Methylpurin-DNA-Glykosylase in Säugerzellen / Thomas Grombacher." Karlsruhe : KIT-Bibliothek, 1995. http://d-nb.info/1124902686/34.

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28

Hu, Yu-Jie. "Roles of Protein Arginine Methyltransferase 7 and Jumonji Domain-Containing Protein 6 in Adipocyte Differentiation: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/797.

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Regulation of gene expression comprises a wide range of mechanisms that control the abundance of gene products in response to environmental and developmental changes. These biological processes can be modulated by posttranslational modifications including arginine methylation. Among the enzymes that catalyze the methylation, protein arginine methyltransferase 7 (PRMT7) is known to modify histones to repress gene expression. Jumonji domain-containing protein 6 (JMJD6) is a putative arginine demethylase that potentially antagonize PRMT7. However, the biological significance of these enzymes is n

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Hu, Yu-Jie. "Roles of Protein Arginine Methyltransferase 7 and Jumonji Domain-Containing Protein 6 in Adipocyte Differentiation: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/797.

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Regulation of gene expression comprises a wide range of mechanisms that control the abundance of gene products in response to environmental and developmental changes. These biological processes can be modulated by posttranslational modifications including arginine methylation. Among the enzymes that catalyze the methylation, protein arginine methyltransferase 7 (PRMT7) is known to modify histones to repress gene expression. Jumonji domain-containing protein 6 (JMJD6) is a putative arginine demethylase that potentially antagonize PRMT7. However, the biological significance of these enzymes is n

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30

Martinez, Marina G. "Genetic Variation of the Beta-2 Adrenergic Receptor and the Phenylethanolamine N-Methyltransferase Enzyme: Influence on Catecholamines, Cardiovascular Regulation, and the Cardiopulmonary Response to Albuterol." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/317802.

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Hypertension, or chronic blood pressure elevation, affects approximately a third of American adults and is responsible for $70 billion dollars annually in medical costs. Recent studies have attempted to identify genetic variants that influence cardiopulmonary function, including blood pressure regulation. This study seeks to determine whether a polymorphism in position -182 of the gene encoding the phenylethanolamine N-methyltransferase (PNMT) enzyme, which converts norepinephrine to epinephrine, influences catecholamine levels and cardiovascular function. Secondly, this study seeks to exp

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31

Chen, Hsiuyi V. "Systematic Dissection of Roles for Chromatin Regulators in Dynamics of Transcriptional Response to Stress in Yeast: A Dissertation." eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/808.

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The following work demonstrates that chromatin regulators play far more pronounced roles in dynamic gene expression than they do in steady-state. Histone modifications have been associated with transcription activity. However, previous analyses of gene expression in mutants affecting histone modifications show limited alteration. I systematically dissected the effects of 83 histone mutants and 119 gene deletion mutants on gene induction/repression in response to diamide stress in yeast. Importantly, I observed far more changes in gene induction/repression than changes in steady-state gene expr

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32

Hildreth, Sherry B. "Investigation of Protein-Protein Interactions among Nicotine Biosynthetic Enzymes and Characterization of a Nicotine Transporter." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/29698.

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Alkaloids are a class of plant secondary metabolites produced in about 20% of plant families. Domesticated tobacco, Nicotiana tabacum produces nicotine as the predominant alkaloid. The biosynthesis of nicotine occurs exclusively in the roots of tobacco, yet accumulates in the leaves of tobacco where it is acts as a defense compound to deter insect herbivory. The research detailed in this dissertation addresses two aspects of nicotine physiology in tobacco: 1) an investigation of hypothesized protein-protein interactions among nicotine biosynthetic enzymes and 2) the characterization of a novel

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Hildreth, Sherry Boston. "Investigation of Protein-Protein Interactions among Nicotine Biosynthetic Enzymes and Characterization of a Nicotine Transporter." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/29698.

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Alkaloids are a class of plant secondary metabolites produced in about 20% of plant families. Domesticated tobacco, Nicotiana tabacum produces nicotine as the predominant alkaloid. The biosynthesis of nicotine occurs exclusively in the roots of tobacco, yet accumulates in the leaves of tobacco where it is acts as a defense compound to deter insect herbivory. The research detailed in this dissertation addresses two aspects of nicotine physiology in tobacco: 1) an investigation of hypothesized protein-protein interactions among nicotine biosynthetic enzymes and 2) the characterization of a novel

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34

Weisberg, Alexandra Jamie. "Investigations into the molecular evolution of plant terpene, alkaloid, and urushiol biosynthetic enzymes." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64408.

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Plants produce a vast number of low-molecular-weight chemicals (so called secondary or specialized metabolites) that confer a selective advantage to the plant, such as defense against herbivory or protection from changing environmental conditions. Many of these specialized metabolites are used for their medicinal properties, as lead compounds in drug discovery, or to impart our food with different tastes and scents. These chemicals are produced by various pathways of enzyme-mediated reactions in plant cells. It is suspected that enzymes in plant specialized metabolism evolved from those in pri

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35

Walbott, Hélène. "Etude biochimique et structurale de deux pyrimidine-c5 méthyltransférases des arn de transfert." Paris 11, 2007. http://www.theses.fr/2007PA112159.

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Dans la cellule, l’ARNt est une molécule-clé de la traduction génétique. Pour être fonctionnel, il doit subir différentes étapes de maturation post-transcriptionnelle, au cours desquelles certains de ses nucléotides sont modifiés chimiquement grâce à des enzymes dites de modification. Mon sujet de thèse a porté sur l’étude biochimique et structurale de deux pyrimidine-C5 méthyltransférases (MTases) des ARNt. Une première partie de mon travail a consisté en la caractérisation biochimique de la cytosine-C5 MTase de S. Cerevisiae, Trm4. L’analyse de son mécanisme catalytique et de son organisatio

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36

Güttler, Bert Hans-Otto [Verfasser], Hans-Ulrich [Akademischer Betreuer] Demuth, Ralph [Akademischer Betreuer] Golbik, and Steffen [Akademischer Betreuer] Roßner. "Untersuchungen zur Bildung von Isoaspartat am Peptid-N-Terminus sowie zur Reparatur durch die Protein-L-isoaspartyl-O-methyltransferase / Bert Hans-Otto Güttler ; Hans-Ulrich Demuth, Ralph Golbik, Steffen Roßner." Halle, 2016. http://d-nb.info/1116951029/34.

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Guéhenneux, Fabienne. "Gènes à motif BTG et contrôle négatif cellulaire." Lyon 1, 1999. http://www.theses.fr/1999LYO1T238.

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38

Hobeika, Maria. "Propriétés stucturales et fonctionnelles du domaine UBA de Mex67 : le récepteur d'export nucléaire des ARNm." Paris 7, 2008. http://www.theses.fr/2008PA077225.

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De manière concomitante à leur synthèse, les ARNm néotranscrits sont sujets à différentes étapes de maturation conduisant à la formation de complexes ribonucléoprotéiques (RNPm) compétents pour l'export. Ces RNPm matures sont reconnus par le récepteur d'export, Mex67 chez la levure, TAP chez les métazoaires, qui assure leur translocation à travers le pore nucléaire. De récentes études ont montré que l'ubiquitination joue un rôle régulateur majeur dans l'export des ARNm. De manière intéressante, Mex67/TAP présente dans sa région C-terminale un domaine UBA (Ubiquitin associated) jusqu'à présent

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Ahrens, Frank. "Wirkung, Permeation und Katabolismus von Histamin an isolierten Dickdarmepithelien des Schweins." Doctoral thesis, Universitätsbibliothek Leipzig, 2004. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-37580.

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Bei Schweinen lassen sich im Anfangsteil des Dickdarms hohe Konzentrationen an Histamin nachweisen. Zum einen wird viel exogenes Histamin in der Ingesta durch Bakterien gebildet. Zum anderen befindet sich im proximalen Kolon viel endogenes Histamin, welches in verschiedenen Populationen von Mastzellen gespeichert ist. Beide Histaminquellen stellen eine potenzielle Gefahr für die Gesundheit des Tieres dar. Sollte Histamin in den vorhandenen Mengen in die Blutzirkulation übertreten, müsste mit dem Tod des Tieres gerechnet werden. Da unter normalen Bedingungen bei Schweinen keine pathophysiologis

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Suh-Lailam, Brenda Bienka. "Development of Novel Methods and their Utilization in the Analysis of the Effect of the N-terminus of Human Protein Arginine Methyltransferase 1 Variant 1 on Enzymatic Activity, Protein-protein Interactions, and Substrate Specificity." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/863.

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Protein arginine methyltransferases (PRMTs) are enzymes that catalyze the methylation of protein arginine residues, resulting in the formation of monomethylarginine, and/or asymmetric or symmetric dimethylarginines. Although understanding of the PRMTs has grown rapidly over the last few years, several challenges still remain in the PRMT field. Here, we describe the development of two techniques that will be very useful in investigating PRMT regulation, small molecule inhibition, oligomerization, protein-protein interaction, and substrate specificity, which will ultimately lead to the advance

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41

Reuben, Melanie. "Characterization of mutant N², N²-dimethylguanosine-specific tRNA methyltransferases from Saccharomyces cerevisiae." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq25984.pdf.

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Ahrens, Frank. "Wirkung, Permeation und Katabolismus von Histamin an isolierten Dickdarmepithelien des Schweins." Doctoral thesis, [S.l.] : [s.n.], 2003. http://dol.uni-leipzig.de/pub/2003-37.

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43

Anthony, Shelagh. "Analysis of mammalian protein arginine N-methyltransferases in the vasculature." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424909.

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44

Chénard, Carol Anne. "Ribonucleoprotein complexes and protein arginine methylation : a role in diseases of the central nervous sytem." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115894.

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For the past 45 years, QKI has been studied for its role in the processes of development and central nervous system myelination using the qkv mouse. The presence of a single KH domain and the recent identification of a high-affinity binding site in mRNAs, suggests that it can bind to and regulate mRNAs through processes such as stability, splicing and transport. As a member of the STAR RNA binding family of proteins the QKI isoforms may also be involved in cell signaling pathways.<br>QKI's involvement in all of these processes, lead us to examine both the protein partners and the mRNA targets

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45

Thomas, Dylan. "Oligomerization dependent enzyme kinetics and mechanistic characterization of type I protein arginine N-methyltransferases." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44623.

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Danne, Linna Maria [Verfasser], Franz [Gutachter] Narberhaus, and Ralf [Gutachter] Erdmann. "Membrane-binding mechanisms of bacterial phospholipid N-methyltransferases / Linna Maria Danne ; Gutachter: Franz Narberhaus, Ralf Erdmann." Bochum : Ruhr-Universität Bochum, 2017. http://d-nb.info/1125106379/34.

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Gleichenhagen, Jan [Verfasser], Franz [Gutachter] Narberhaus, and Eckhard [Gutachter] Hofmann. "Bakterielle Phospholipid N-Methyltransferasen : Charakterisierung enzymatischer Eigenschaften und Substratspezifitäten / Jan Gleichenhagen ; Gutachter: Franz Narberhaus, Eckhard Hofmann ; Fakultät für Biologie und Biotechnologie." Bochum : Ruhr-Universität Bochum, 2013. http://d-nb.info/1212661362/34.

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Zheng, Sushuang. "Structure-function analyses of Encephalitozoon cuniculi : and vaccinia virus mRNA cap (guanine N-7) methyltransferases and sinefungin resistance of Saccharomyces cerevisiae /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1528353811&sid=5&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Jiang, Yan. "Chromatin Remodeling in Transgenic Mouse Brain: Implications for the Neurobiology of Depression: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/423.

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Histone lysine methylation is an important epigenetic mark for regulation of gene expression and chromatin organization. Setdb1 (Set domain, bifurcate 1), one of the histone lysine methyltransferases, specifically methylates histone H3 at lysine 9 (H3K9) and participates in transcriptional repression and heterochromatin formation. The major task of my thesis work was to investigate the epigenetic roles of Setdb1 in regulating brain functions. I started my thesis work by examining Setdb1 expression pattern during mouse brain development. The most robust signal of Setdb1 was detected in the feta

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Marechal, Nils. "Étude structurale des protéine arginine méthyltransférases : reconnaissance des substrats et conception rationnelle de modulateurs." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ048.

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Les protéine arginine méthyltransférases (PRMT) sont impliquées dans de nombreux processus cellulaires, incluant la régulation de l’expression des gènes, le contrôle de l’épissage, le maintien de l’intégrité du génome et la transduction du signal. De nombreuses études montrent que la dérégulation de l’activité des PRMT est associée au développement de pathologies, et en particulier de cancers. Les PRMT constituent ainsi une des nouvelles cibles potentielles en chimiothérapie. Les travaux présentés dans ce manuscrit portent sur trois cibles : PRMT2, PRMT3 et PRMT4/CARM1. Combinant des approches

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