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Journal articles on the topic 'N-stearoylethanolamine'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Chumak, A., A. Berdyshev, G. Kosyakova, V. Talko, and N. Gula. "Potential use of N-stearoylethanolamine in radiation medicine." Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 20 (2015): 137–46. http://dx.doi.org/10.33145/2304-8336-2015-20-137-146.

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2

Chumak, A., V. Talko, N. Atamanyuk, et al. "Transgeneration effects of N-stearoylethanolamine in irradiated rats." Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 22 (2017): 270–81. http://dx.doi.org/10.33145/2304-8336-2017-22-270-281.

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3

Onopchenko, O. V., G. V. Kosiakova, T. M. Goridko, V. M. Klimashevsky, and N. M. Hula. "The effect of N-stearoylethanolamine on liver phospholipid composition." Ukrainian Biochemical Journal 86, no. 1 (2014): 101–10. http://dx.doi.org/10.15407/ubj86.01.101.

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4

Manko, N., M. Lootsik, V. Antonyuk, et al. "Multifunctional chitosan-based hydrogels: characterization and evaluation of biocompatibility and biodegradability in vitro." Ukrainian Biochemical Journal 96, no. 1 (2024): 80–95. http://dx.doi.org/10.15407/ubj96.01.080.

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Creation of novel remedies efficient in supporting wound healing remains an actual task in pharmacology. Hydrogels showed high efficiency in wound healing and tissue regeneration due to viscosity, elasticity and fluidity that provide them with functional characteristics similar to that in extracellular matrix. The aim of the study was to create chitosan-based hydrogels functionalized with different components (chondroitin-6-sulfate, hyaluronic acid, N-stearoylethanolamine) and to estimate their biocompatibility and biodegradability in vitro. For the first time, a lipid substance N-stearoyleth

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5

Horid’ko, T. M., H. V. Kosiakova, and A. G. Berdyshev. "Antistress effects of N-stearoylethanolamine in rats with chronic social stress." Ukrainian Biochemical Journal 89, no. 4 (2017): 68–76. http://dx.doi.org/10.15407/ubj89.04.068.

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6

Hula, N. M., A. A. Chumak, A. G. Berdyshev, et al. "N-stearoylethanolamine - a new inhibitor of the hepatitis C virus reproduction." Biopolymers and Cell 37, no. 3 (2021): 167–76. http://dx.doi.org/10.7124/bc.000a54.

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7

Bondarenko, Oleksandr V., N. M. Hula, Mykola Yu Makarchuk, T. M. Horid'ko, and O. A. Kovalenko. "Effects of N-Stearoylethanolamine on the Emotionality and Learning Ability of Rats." International Journal of Physiology and Pathophysiology 6, no. 4 (2015): 277–86. http://dx.doi.org/10.1615/intjphyspathophys.v6.i4.20.

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8

Zhukov, A. D. "N-stearoylethanolamine effect on the level of 11-hydroxycorticosteroids, cytokines IL-1?,." Ukrainian Biochemical Journal 86, no. 3 (2014): 88–97. http://dx.doi.org/10.15407/ubj86.03.088.

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9

Bondarenko, OV, NM Hula, MIu Makarchuk, TM Horid'ko, and OA Kovalenko. "Effects of N-stearoylethanolamine on the emotionality and learning ability of rats." Fiziolohichnyĭ zhurnal 60, no. 5 (2014): 52–61. http://dx.doi.org/10.15407/fz60.05.052.

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10

Onopchenko, Oleksandra V., Galina V. Kosiakova, Murat Oz, Vitaliy M. Klimashevsky, and Nadiya M. Gula. "N-Stearoylethanolamine Restores Pancreas Lipid Composition in Obesity-Induced Insulin Resistant Rats." Lipids 50, no. 1 (2014): 13–21. http://dx.doi.org/10.1007/s11745-014-3960-1.

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11

Wouters, J., S. Vandevoorde, C. Culot, F. Docquir, and D. M. Lambert. "Polymorphism of N-stearoylethanolamine: differential scanning calorimetric, vibrational spectroscopic (FTIR), and crystallographic studies." Chemistry and Physics of Lipids 119, no. 1-2 (2002): 13–21. http://dx.doi.org/10.1016/s0009-3084(02)00031-2.

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12

Onopchenko, O. V., G. V. Kosiakova, and N. M. Gula. "N-stearoylethanolamine improves indicators of insulin resistance development under high-fat diet overload." Atherosclerosis 241, no. 1 (2015): e226. http://dx.doi.org/10.1016/j.atherosclerosis.2015.04.1055.

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13

Pavlut, T. О., Т. B. Melik-Kasumov, I. P. Zhavoronok, et al. "The Effect of N-palmitoylethanolamine and N-stearoylethanolamine in Liposomes on the Healing of Experimental Skin Wounds." Novosti Khirurgii 24, no. 5 (2016): 425–35. http://dx.doi.org/10.18484/2305-0047.2016.5.425.

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14

Berdyshev, Andrey G., Halyna V. Kosiakova, Oleksandra V. Onopchenko, Rostislav R. Panchuk, Rostislav S. Stoika та Nadiya M. Hula. "N-Stearoylethanolamine suppresses the pro-inflammatory cytokines production by inhibition of NF-κB translocation". Prostaglandins & Other Lipid Mediators 121 (вересень 2015): 91–96. http://dx.doi.org/10.1016/j.prostaglandins.2015.05.001.

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15

Onopchenko, O., H. Kosiakova, A. Berdyshev, and N. Hula. "Anti-inflammatory action of N-stearoylethanolamine in rat peritoneal macrophages during high fat feeding." Atherosclerosis 275 (August 2018): e194. http://dx.doi.org/10.1016/j.atherosclerosis.2018.06.598.

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16

Onopchenko, O. V. "The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance." Ukrainian Biochemical Journal 87, no. 1 (2015): 46–54. http://dx.doi.org/10.15407/ubj87.01.046.

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17

Berdyshev, A. G., H. V. Kosiakova, and N. M. Hula. "Modulation of LPS-induced ROS production and NF-?B nuclear translocation by N-stearoylethanolamine in macrophages." Ukrainian Biochemical Journal 89, no. 5 (2017): 62–69. http://dx.doi.org/10.15407/ubj89.05.062.

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18

Tkachenko, O. S., and H. V. Kosiakova. "Diet-induced and age-related changes in rats: the impact of N-stearoylethanolamine intake on plasma lipoproteins, adiponectin, and adipocyte cholesterol-phospholipid composition." Ukrainian Biochemical Journal 96, no. 2 (2024): 84–99. http://dx.doi.org/10.15407/ubj96.02.084.

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Adiponectin is secreted by adipose tissue, associated with lipoprotein (LP) metabolism, down-regulated in insulin resistance states, and reduced in individuals suffering from obesity and cardiovascular diseases. Phospholipids and cholesterol are the main components of cell membranes and play a critical role in storage and secretory adipocyte functions. N-stearoylethanolamine (NSE) is a minor lipid affecting cell membrane lipids’ composition. Our study aimed to investigate plasma levels of adiponectin and cholesterol of low- and high-density LP (LDL and HDL) and adipocyte cholesterol-phospholi

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19

Ibrahimov, K. V. "THE EFFECT OF N-STEAROYLETHANOLAMINE ON THE STRESS HORMONES LEVELS IN OLD RATS WITH INDUCED CHRONIC INFLAMMATION." Biotechnologia Acta 17, no. 2 (2024): 49–51. http://dx.doi.org/10.15407/biotech17.02.048.

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Numerous studies aimed at elucidating the evolutionary acquisition of the endocannabinoid system gradually expand our understanding of the development and functioning of living organisms. It is now well-known the indispensable role of endocannabinoids in higher nervous activity and other signaling high-activity compounds. Among the representatives of this system are saturated long-chain N-acyl ethanolamines, including N-stearoylethanolamine. Previous studies have illuminated a range of important functional features of NSE on various biochemical processes, including anti-inflammatory, neuroprot

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20

Berdyshev, A. G., N. M. Gulaya, A. A. Chumak, and N. L. Kindruk. "Effect of N-stearoylethanolamine on free amino acid levels in rat plasma and liver with burn." Biomeditsinskaya Khimiya 57, no. 4 (2011): 446–54. http://dx.doi.org/10.18097/pbmc20115704446.

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The effect of the endocannabinoid congener N-stearoylethanolamine (NSE) on the content of plasma and liver free amino acids in burned rats was studied. The animals after the thermal burn of the skin received per os during 7 days the water suspension of NSE in the doze 10 mg/kg of body weight. In the other group of rats the suspension was applied on the wound (the concentration of NSE was 10 mg/ml). In experimental animals the total amount of free amino acids in plasma decreased after burn while the total amount of free amino acids in liver significantly increased. In burn animals the ratio of

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21

ARTAMONOV, M. "P3235 Influence of N-stearoylethanolamine on lipid composition of isolated rat heart under post-ischaemic reperfusion." European Heart Journal 24, no. 5 (2003): 609. http://dx.doi.org/10.1016/s0195-668x(03)95861-1.

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22

Oksana, Tkachenko, Kosiakova Halyna, Klimashevsky Vitalii, Berdyshev Andrii, and Hula Nadiia. "THE EFFECT OF N-STEAROYLETHANOLAMINE ON THE ADIPOCYTE FATTY ACID COMPOSITION OF DIFFERENT AGE RATS WITH OBESITY-INDUCED INSULIN RESISTANCE." EUREKA: Life Sciences 2 (March 31, 2020): 10–23. https://doi.org/10.21303/2504-5695.2020.001194.

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Chronic hypernutrition and high fat diet (HFD), rich in saturated fatty acids leads to molecular changes in insulin sensitive tissues and is followed by dyslipidemia. That is why the aim of our study was to investigate the fatty acid (FA) composition of phospholipids (PL), free fatty acids (FFA), triacylglycerol (TAG) and cholesterol esters (CE) of adipocytes in different age rats with HFD-induced insulin resistance (IR) and its changes under N-stearoylethanolamine (NSE) administration. The experimental model was induced on rats in age 10-month-old and 24-month-old by 6-month HFD and confirmed

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23

PUSHKAREV, Vladimir, Nikolai TRONKO, Nadja KOSTYUCHENKO, Andrei KOVALENKO, and Alexei MIKOSHA. "Modulation by N-stearoylethanolamine of K+ and Mitotane Effects on Steroid Hormones Labeling in Human Adrenocortical Tissue." Biomedical Research 22, no. 4 (2001): 191–95. http://dx.doi.org/10.2220/biomedres.22.191.

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24

Tkachenko, O. S., Ie A. Hudz, H. V. Kosiakova, and P. P. Klymenko. "Protective action of N-stearoylethanolamine on blood coagulation and arterial changes in spontaneously hypertensive rats fed cholesterol-rich diet." Ukrainian Biochemical Journal 92, no. 2 (2020): 60–70. http://dx.doi.org/10.15407/ubj92.02.060.

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25

Manko, N., I. Ivasechko, R. Antonyuk, et al. "Chitosan-Based Hydrogels with N-Stearoylethanolamine for Acceleration of Healing of Acute Cutaneous Wounds: Cytological and Histological Examination." Cytology and Genetics 59, no. 1 (2025): 24–35. https://doi.org/10.3103/s0095452725010086.

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26

Keereetaweep, Jantana, and Kent D. Chapman. "Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification." Neural Plasticity 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/2426398.

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The endocannabinoidsN-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups ofN-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively. They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors found in various organisms. After AEA and 2-AG were discovered in the 1990s, they have been extensively documented to have a broad range of physiological functions. Along with AEA, several NAEs, for example,N-palmitoylethanolamine (PEA),N-stearoylethanolamine (SEA), andN-oleoylethanola

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27

Dziuba, O. S., Ie A. Hudz, and H. V. Kosiakova. "The effect of N-stearoylethanolamine on adipocytes free cholesterol content and phospholipid composition in rats with obesity-induced insulin resistance." Ukrainian Biochemical Journal 90, no. 5 (2018): 81–90. http://dx.doi.org/10.15407/ubj90.05.081.

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28

Romanenko, K. S. "EFFECT OF N-STEAROYLETHANOLAMINE ON THE LIPID COMPOSITION OF THE FRONTAL CORTEX AND HIPPOCAMPUS OF THE RAT'S BRAIN AT THE AGING." Biotechnologia Acta 15, no. 2 (2022): 66–67. http://dx.doi.org/10.15407/biotech15.02.066.

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Aim. To study the possible protective effect of cannabimimetic lipid - N-stearoylethanolamine (NSE) on the lipid composition of the frontal cortex, hippocampus and on the state of episodic memory of old rats. Methods. Extraction of lipids from the tissues of the hippocampus and frontal cortex of rats was performed by the method of Bligh and Dyer. Phospholipids were separated by two-dimensional thin layer chromatography. Methyl esters of fatty acids from lipid extract were obtained by a modified method of Carreau and Dubaco. Quantitative analysis of fatty acid methyl esters was performed by gas

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29

Horid’ko, T. M., H. V. Kosiakova, and A. G. Berdyshev. "Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment." Ukrainian Biochemical Journal 90, no. 6 (2018): 97–109. http://dx.doi.org/10.15407/ubj90.06.097.

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30

Berdyshev, A. G., N. M. Gulaya, A. A. Chumak, and N. L. Kindruk. "The effect of N-stearoylethanolamine on free amino acid levels in plasma and liver of rats with an experimental burn." Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 5, no. 1 (2011): 44–50. http://dx.doi.org/10.1134/s1990750811010033.

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31

Tkachenko, Oksana, Halyna Kosiakova, Vitalii Klimashevsky, Andrii Berdyshev, and Nadiia Hula. "THE EFFECT OF N-STEAROYLETHANOLAMINE ON THE ADIPOCYTE FATTY ACID COMPOSITION OF DIFFERENT AGE RATS WITH OBESITY-INDUCED INSULIN RESISTANCE." EUREKA: Life Sciences 2 (March 31, 2020): 10–23. http://dx.doi.org/10.21303/2504-5695.2020.001194.

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Chronic hypernutrition and high fat diet (HFD), rich in saturated fatty acids leads to molecular changes in insulin sensitive tissues and is followed by dyslipidemia. That is why the aim of our study was to investigate the fatty acid (FA) composition of phospholipids (PL), free fatty acids (FFA), triacylglycerol (TAG) and cholesterol esters (CE) of adipocytes in different age rats with HFD-induced insulin resistance (IR) and its changes under N-stearoylethanolamine (NSE) administration. The experimental model was induced on rats in age 10-month-old and 24-month-old by 6-month HFD and confirmed

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32

Kvitnitskaya-Ryzhova, Tatiana Yu, Halyna V. Kosiakova, Sergiy P. Lugovskoy, et al. "AGE-RELATED MORPHO-FUNCTIONAL CHANGES IN RATS’ PANCREAS UNDER HIGH-FAT DIET-INDUCED INSULIN RESISTANCE AND ITS PHARMACOLOGICAL TREATMENT." Wiadomości Lekarskie 74, no. 2 (2021): 241–46. http://dx.doi.org/10.36740/wlek202102112.

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The aim: To determine the set of structural and functional changes in pancreatic islets (PI) of obesity-induced insulin resistant (IR) rats of different age (young and old) fed with prolonged (6 month) high-fat diet (HFD) (58% of fat) and further treatment with N-Stearoylethanolamine (NSE), a bioactive N-Acylethanolamine. Materials and methods: Alimentary obesity-induced IR model in rats of two age groups was used to investigate the influence of age and NSE treatment on pancreas morphology (using histological, histochemical and immunohistochemical techniques) and on several biochemical paramet

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33

Lykhmus, Olena, Olena Kalashnyk, Kateryna Uspenska та ін. "Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice". Biomolecules 10, № 2 (2020): 226. http://dx.doi.org/10.3390/biom10020226.

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Nicotinic acetylcholine receptors of α7 subtype (α7 nAChRs) are involved in regulating neuroinflammation and cognitive functions. Correspondingly, α7-/- mice demonstrate pro-inflammatory phenotype and impaired episodic memory. In addition, nAChRs expressed in mitochondria regulate the release of pro-apoptotic factors like cytochrome c. Here we studied whether the cognitive deficiency of α7-/- mice can be cured by oral consumption of either nicotine or N-stearoylethanolamine (NSE), a lipid possessing anti-inflammatory, cannabimimetic and membrane-stabilizing activity. Mice were examined in Nove

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34

Onopchenko, O. V. "The effect of N-stearoylethanolamine on cholesterol content, fatty acid composition and protein carbonylation level in rats with alimentary obesity-induced insulin resistance." Ukrainian Biochemical Journal 86, no. 6 (2014): 119–28. http://dx.doi.org/10.15407/ubj86.06.119.

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35

Onopchenko, O. V., T. M. Horid’ko та H. V. Kosiakova. "The effect of N-stearoylethanolamine on the lipid composition of the rat testes and testosterone level during the early stages of streptozotocin-іnduced diabetes". Ukrainian Biochemical Journal 92, № 2 (2020): 45–58. http://dx.doi.org/10.15407/ubj92.02.045.

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36

Panchuk, Rostyslav, Nadiya Skorokhyd, Vira Chumak, et al. "Cannabimimetic N-Stearoylethanolamine as “Double-Edged Sword” in Anticancer Chemotherapy: Proapoptotic Effect on Tumor Cells and Suppression of Tumor Growth versus Its Bio-Protective Actions in Complex with Polymeric Carrier on General Toxicity of Doxorubicin In Vivo." Pharmaceutics 15, no. 3 (2023): 835. http://dx.doi.org/10.3390/pharmaceutics15030835.

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This study reports a dose-dependent pro-apoptotic action of synthetic cannabimimetic N-stearoylethanolamine (NSE) on diverse cancer cell lines, including multidrug-resistant models. No antioxidant or cytoprotective effects of NSE were found when it was applied together with doxorubicin. A complex of NSE with the polymeric carrier poly(5-(tert-butylperoxy)-5-methyl-1-hexen-3-yn-co-glycidyl methacrylate)-graft-PEG was synthesized. Co-immobilization of NSE and doxorubicin on this carrier led to a 2-10-fold enhancement of the anticancer activity, particularly, against drug-resistant cells overexpr

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37

Kvitnitskaya-Ryzhova, T. Yu, S. P. Lugovskyi, P. P. Klymenko, et al. "THE INFLUENCE OF AGE FACTOR ON CHANGES IN MORPHOMETRIC INDICES OF RAT PANCREAS IN MODELING OF INSULIN RESISTANCE AND ITS CORRECTION WITH N-STEAROYLETHANOLAMINE." World of Medicine and Biology 18, no. 80 (2022): 204. http://dx.doi.org/10.26724/2079-8334-2022-2-80-204-209.

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38

Lykhmus, Olena, Kateryna Uspenska, Lyudmyla Koval та ін. "N-Stearoylethanolamine protects the brain and improves memory of mice treated with lipopolysaccharide or immunized with the extracellular domain of α7 nicotinic acetylcholine receptor". International Immunopharmacology 52 (листопад 2017): 290–96. http://dx.doi.org/10.1016/j.intimp.2017.09.023.

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39

Onopchenko, O. V. "The effect of N-stearoylethanolamine on the activity of antioxidant enzymes, content of lipid peroxidation products and nitric oxide in the blood plasma and liver of rats with induced insulin-resistance." Ukrainian Biochemical Journal 85, no. 6 (2013): 88–96. http://dx.doi.org/10.15407/ubj85.05.088.

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40

Gudz, E. A. "Antitoxic and antioxidant effects of N-stearoylethanolamin in the content of nanocomposite complex with doxorubicin in organs of mice with Lewis carcinoma." Ukrainian Biochemical Journal 85, no. 6 (2013): 97–104. http://dx.doi.org/10.15407/ubj85.05.097.

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41

Halyna, Kosiakova, Berdyshev Andrii, Horid’ko Tetyana, et al. "N-Stearoylethanolamine Exerts Cardioprotective Effects in Old Rats." Current Aging Science 17 (January 25, 2024). http://dx.doi.org/10.2174/0118746098275323231226073348.

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Background:: Aging is associated with the slowing down of metabolic processes, diminished physiological processes, changes in hormonal activity and increasing exposure to oxidative stress factors and chronic inflammation. The endocannabinoid system (ECS) is a major signaling network that plays a pro-homeostatic role in the central and peripheral organs of the human body. A class of minor lipids, N-acylethanolamines (NAEs), which do not activate cannabinoid receptors, except for anandamide, but can potentiate the action of endocannabinoids and have a wide spectrum of biological activity and sig

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42

Bondarenko, Oleksandr V., N. M. Hula, M. Yu Makarchuk, and T. M. Horid’ko. "Effects of N-stearoylethanolamine on anxiety-like behavioral reactions of rats after chronic alcoholization." Biologija 60, no. 1 (2014). http://dx.doi.org/10.6001/biologija.v60i1.2862.

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43

Kosiakova, H., A. Berdyshev, V. Dosenko, T. Drevytska, O. Herasymenko та N. Hula. "The involvement of peroxisome proliferator-activated receptor gamma (PPARγ) in anti-inflammatory activity of N-stearoylethanolamine". Heliyon, жовтень 2022, e11336. http://dx.doi.org/10.1016/j.heliyon.2022.e11336.

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44

Hudz, Iehor A., Volodymyr Chernyshenko, Ludmila O. Kasatkina, et al. "N-stearoylethanolamine inhibits integrin-mediated activation, aggregation and adhesion of human platelets ." Journal of Pharmacology and Experimental Therapeutics, August 13, 2022, JPET—AR—2022–001084. http://dx.doi.org/10.1124/jpet.122.001084.

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45

Pantell, Matthew S., Patricia P. Silveira, Euclides José de Mendonça Filho, et al. "Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children." Pediatric Research, January 17, 2024. http://dx.doi.org/10.1038/s41390-023-02992-6.

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Abstract Background Prior work has found relationships between childhood social adversity and biomarkers of stress, but knowledge gaps remain. To help address these gaps, we explored associations between social adversity and biomarkers of inflammation (interleukin-1β [IL-1β], IL-6, IL-8, tumor necrosis factor-alpha [TNF-α], and salivary cytokine hierarchical “clusters” based on the three interleukins), neuroendocrine function (cortisol, cortisone, dehydroepiandrosterone, testosterone, and progesterone), neuromodulation (N-arachidonoylethanolamine, stearoylethanolamine, oleoylethanolamide, and

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