Academic literature on the topic 'N.T. Luke II'
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Journal articles on the topic "N.T. Luke II"
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Wang, Jie, Adam S. Asch, Nada Hamad, Andrew Weickhardt, Monika Tomaszewska-Kiecana, Monika Dlugosz-Danecka, Halyna Pylypenko, et al. "A Phase 1, Open-Label Study of MGD013, a Bispecific DART® Molecule Binding PD-1 and LAG-3 in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma." Blood 136, Supplement 1 (November 5, 2020): 21–22. http://dx.doi.org/10.1182/blood-2020-139868.
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Background: MGD013 is an investigational, first-in-class, Fc-bearing bispecific tetravalent DART molecule designed to bind PD-1 and LAG-3 and sustain/restore the function of exhausted T cells (1). MGD013 demonstrates in vitro ligand blocking properties and improved T-cell responses beyond that observed with anti-PD-1 and anti-LAG-3 benchmark antibodies alone or in combination. PD-1 targeted therapy with nivolumab in patients (pts) with relapsed or refractory (R/R) diffuse large B cell lymphoma (DLBCL) has yielded modest efficacy (2). LAG-3, highly expressed in DLBCL (3), has emerged as another therapeutic target of interest in this population with continued unmet need. Methods: This study characterizes the safety, tolerability, dose-limiting toxicities, maximum tolerated dose, PK/PD, and antitumor activity of MGD013 in pts with advanced solid and hematologic malignancies. R/R DLBCL pts are being treated at the recommended Phase 2 dose of 600 mg every two weeks in Cohort Expansion. Results: At data-cutoff, 17 DLBCL pts received MGD013 (2.5 median prior lines of therapy, 41.2% with prior CAR-T therapy). Treatment-related adverse events (TRAEs) occurred in 11/17 (64.7%) pts, with no same TRAE occurring in > 1 patient except pyrexia (n=3). One grade ≥ 3 TRAE occurred (pneumonia), and no events of tumor lysis syndrome were observed. Among 11 response-evaluable pts (i.e. received at least one on-treatment scan), 1 complete response (CR) and 3 partial responses (PRs) per the Lugano Classification were observed. Analyses of available pre-treatment tumor biopsy samples corresponding to responding pts demonstrated relatively high levels of LAG-3, PD-1, and PD-L1 by IHC. More comprehensive translational analyses were undertaken for the pt with CR, observed after a single MGD013 infusion in a 28-year-old male in relapse 6 months after CD19-directed CAR T-cell therapy. In contrast to a pre-CAR T biopsy specimen demonstrating no LAG-3 or PD-1 expression, IHC analysis of a lymph node specimen biopsied post-CAR T and prior to MGD013 treatment revealed high levels of both LAG-3 and PD-1 on both infiltrating T-cells and malignant B-cells. Consistent with CD19 CAR T resistance, no CD19 expression was evident. MHC class II and PD-L1 expression were observed, which when bound to LAG-3 and PD-1, respectively, form immune checkpoints that can decrease T cell function. Following MGD013 treatment, serum IFN-γ markedly increased to >140-fold above baseline. No significant changes were observed for IL-6 or IL-2. Expansion of circulating CD3+CD8+ and CD3+CD4-CD8- T-cell subsets and associated cytolytic markers (i.e., perforin, granzyme B) were observed following MGD013 treatment. The patient underwent allogeneic stem cell transplant (allo-SCT) and remains in remission 14 months post-MGD013 and 12 months post-allo-SCT. Further correlative biomarker analyses are underway in the ongoing clinical trial. Conclusion: MGD013, a novel molecule designed to coordinately block PD-1 and LAG-3, has preliminarily demonstrated an acceptable safety profile and encouraging early evidence of anti-tumor activity in R/R DLBCL pts with and without prior treatment with CAR T. Biomarker analyses confirmed expression of both PD-1 and LAG-3 axes in responding pts with evidence of pharmacodynamic responses consistent with the ability of MGD013 to enhance T-cell function. References: 1. Luke JJ, Patel MR, Hamilton E, et al. A phase I, first-in-human, open-label, dose-escalation study of MGD013, a bispecific DART molecule binding PD-1 and LAG-3, in patients with unresectable or metastatic neoplasms. J Clin Oncol 38: 2020 (suppl; abstr 3004). 2. Keane C, Law SC, Gould C, et al. LAG3: a novel immune checkpoint expressed by multiple lymphocyte subsets in diffuse large B-cell lymphoma. Blood Adv. 2020;4(7):1367-1377. doi:10.1182/bloodadvances.2019001390 3. Ansell SM, Minnema MC, Johnson P, et al., Nivolumab for Relapsed/Refractory Diffuse Large B-Cell Lymphoma in Patients Ineligible for or Having Failed Autologous Transplantation: A Single-Arm, Phase II Study. J Clin Oncol, 2019. 37(6): p. 481-489. Disclosures Wang: Verastem Oncology: Membership on an entity's Board of Directors or advisory committees; Curio Science: Honoraria; Putnam LLC: Honoraria. Asch:Astellas Pharma: Research Funding; Cartesian: Research Funding; Forty Seven: Research Funding; Juno: Research Funding; MacroGenics: Research Funding; MEI Pharma: Patents & Royalties: Provisional patent submitted (I), Research Funding. Hamad:Novartis: Honoraria; Abbvie: Honoraria. Weickhardt:Merck: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS: Membership on an entity's Board of Directors or advisory committees, Research Funding; Ipsen: Membership on an entity's Board of Directors or advisory committees; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Ulahannan:Merck Co. Inc: Research Funding; Bayer: Membership on an entity's Board of Directors or advisory committees; G1 Therapeutics, Inc.: Research Funding; ArQule, Inc.: Research Funding; Evelo Biosciences, Inc.: Research Funding; Incyte: Membership on an entity's Board of Directors or advisory committees, Research Funding; Klus Pharma, Inc.: Research Funding; Isofol: Research Funding; GlaxoSmithKline GSK: Research Funding; Mersana Therapeutics: Research Funding; Macrogenics: Research Funding; Celgene Corporation: Research Funding; Boehringer Ingelheim: Research Funding; Array: Membership on an entity's Board of Directors or advisory committees; Ciclomed LLC: Research Funding; AbbVie, Inc.: Research Funding; AstraZeneca: Research Funding; Bristol-Myers Squibb: Research Funding; Syros: Membership on an entity's Board of Directors or advisory committees; Exelxis: Membership on an entity's Board of Directors or advisory committees. Koucheki:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Sun:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Li:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Chen:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Zhang:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Muth:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Kaminker:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Moore:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Sumrow:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company.
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Baltas, M., J. D. Bastide, L. Cazaux, L. Gorrichon-Guigon, P. Maroni, and P. Tisnes. "Zinc(II) complexes of sulfinamides—II. t-Butyl N-(hydroxyphenyl) and t-butyl N-(o-aminophenyl) sulfinamoyl acetates." Spectrochimica Acta Part A: Molecular Spectroscopy 41, no. 6 (January 1985): 793–96. http://dx.doi.org/10.1016/0584-8539(85)80023-4.
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Ha, Kwang. "Crystal structure of (1,4,8,11-tetraazacyclotetradecane-κ4N,N′,N′′,N′′′)palladium(II) tetracyanonickelate(II), C14H24N8NiPd." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 1 (December 18, 2019): 77–78. http://dx.doi.org/10.1515/ncrs-2019-0497.
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Doğan, F., M. Ulusoy, Ö. F. Öztürk, İ. Kaya, and B. Salih. "Thermal studies of Co(II), Ni(II) and Cu(II) complexes of N,N′-bis(3,5-Di-t-butylsalicylidene)ethylenediamine." Journal of Thermal Analysis and Calorimetry 96, no. 1 (March 12, 2009): 267–76. http://dx.doi.org/10.1007/s10973-008-8980-8.
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Ha, Kwang. "Crystal structure of cyclo[tetra(μ2-cyanido)-tetracyanido-bis(1,4,7,10-tetraazacyclododecane-κ4N,N′,N′′,N′′′)dinickel(II)dipalladium(II)] hexahydrate, C24H52N16Ni2O6Pd2." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 1 (December 18, 2019): 201–2. http://dx.doi.org/10.1515/ncrs-2019-0574.
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AbstractC24H52N16Ni2O6Pd2, monoclinic, P21/c (no. 14), a = 8.6416(3) Å, b = 14.2237(5) Å, c = 15.5573(5) Å, β = 93.8054(12)°, V = 1908.02(11) Å3, Z = 2, Rgt(F) = 0.0312, wRref(F2) = 0.0915, T = 223(2) K.
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Maher, P. J. "Commutator and self-commutator approximants II." Filomat 24, no. 4 (2010): 1–7. http://dx.doi.org/10.2298/fil1004001m.
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We minimize the quantities (i) ||T -(AX-X A) ||, (ii) ||T -(X*X-XX*)|| and (iii) ||T -(AX - X B)|| where T is isometric and where in (i) A is paranormal and commutes with T , in (ii) X*(or X ) is paranormal and commutes with T , and in (iii) A and B are paranormal and AT = T B and T A = BT. The upshot is that these quantities are minimized when 0 = AX - XA = X*X - XX*= AX - XB. To prove these results we obtain the power norm equality for paranormal operators: if A is paranormal then ||An|| = ||A||n if n?N.
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Killinger, William A., Thomas W. Rice, David J. Adelstein, Sharon V. Medendorp, Gregory Zuccaro, Thomas J. Kirby, and John R. Goldblum. "Stage II esophageal carcinoma: The significance of T and N." Journal of Thoracic and Cardiovascular Surgery 111, no. 5 (May 1996): 935–40. http://dx.doi.org/10.1016/s0022-5223(96)70367-7.
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Kim, Kang-Woo, and Jinhee Kim. "Crystal structure of bis(N,N,N-triethylammonium) bis(tetraselenido-κ2Se1,Se4)palladate(II), C12H32N2PdSe8." Zeitschrift für Kristallographie - New Crystal Structures 230, no. 3 (September 1, 2015): 269–70. http://dx.doi.org/10.1515/ncrs-2014-9015.
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Baltas, M., J. D. Bastide, A. de Blic, L. Cazaux, L. Gorrichon-Guigon, P. Maroni, M. Perry, and P. Tisnes. "Zinc(II) complexes of sulfinamides—I. N-Phenyl 2-propane sulfinamide, t-butyl N-phenyl and t-butyl N-cyclohexyl sulfinamoyl acetates." Spectrochimica Acta Part A: Molecular Spectroscopy 41, no. 6 (January 1985): 789–92. http://dx.doi.org/10.1016/0584-8539(85)80022-2.
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Mao, Pan-Dong, Xiao-Lei Zhao, Qing-Wen Yang, Miao Yang, and Yuan Wang. "Crystal structure of [N,N-bis((pyrrol-2-yl)ethylidene)butane-1,4-diamine-κ4N,N′,N′′,N′′′]-nickel(II), C16H20N4Ni." Zeitschrift für Kristallographie - New Crystal Structures 233, no. 1 (January 26, 2018): 101–2. http://dx.doi.org/10.1515/ncrs-2017-0190.
Full textDissertations / Theses on the topic "N.T. Luke II"
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Dutra, Rafael Antonio Faraone. "A presença do Prólogo do Quarto Evangelho no gnosticismo alexandrino do século II." Pontifícia Universidade Católica de São Paulo, 2018. https://tede2.pucsp.br/handle/handle/20928.
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Submitted by Filipe dos Santos (fsantos@pucsp.br) on 2018-03-26T12:27:38Z
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Pontifícia Universidade Católica de São Paulo - PUCSP
The similarity of John writings and the gnostics is still a lasting subject nowadays. All discoveries that attempt to clear things up get people’s attention. The discoveries of Nag Hammadi writings, whose some texts are gnostics, points at an Alexandrian II century AD Gnosticism that suffered from various influences, mostly Johannine. The exploration of such environment allow us not only to notice John richness, but also his diffusion in religious environments. Some of the writings of Nag Hammadi, as Trimorfaic Protenor, John Apocryphal and Gospel of Truth, have vocabularies and thematic affinities with the Fourth Gospel, especially with the Prologue. Through the similarity with the quoted texts, the question arises whether the texts of Alexandrian II century AD were used from John prologue to his composition. The hypothesis is that somehow the Gnostics had contact with the Johannine prologue and used their concepts to base their teachings. In order to answer this question, this work has bibliographic character, using the literature concerning the prologue of the Fourth Gospel and the analysis of the quoted texts and the prologue, from the tradition and the contemporary exegesis
A semelhança entre os escritos de João e os gnósticos é um assunto que continua em pauta atualmente. As descobertas que são feitas, em uma tentativa de lançar luz sobre o tema, chamam a atenção de todos. As descobertas dos escritos de Nag Hammadi, que possui alguns textos de autoria gnóstica, apontam para um gnosticismo alexandrino do século II d.C. que sofreu várias influências, mas principalmente a joanina. Explorar esse ambiente permite contemplar não apenas a riqueza de João como também sua difusão em ambientes religiosos. Alguns escritos de Nag Hammadi, como Protenoia Trimorfa, Apócrifo de João e Evangelho da Verdade, possuem afinidades vocabulares e temáticas com o Quarto Evangelho, sobretudo com o Prólogo. Através da semelhança com os textos citados, surge a pergunta se os textos do gnosticismo alexandrino do século II d.C. teriam se utilizado do Prólogo de João para sua composição. A hipótese é que de alguma forma os gnósticos tiveram contato com o Prólogo joanino e utilizaram seus conceitos para embasar seus ensinamentos. A fim de responder a tal questão este trabalho possui caráter bibliográfico, utilizando-se da literatura a respeito do Prólogo do Quarto Evangelho e da análise dos textos citados e do Prólogo, a partir da Tradição e da exegese contemporânea
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Nascimento, Junior Maurino Marques. "Exigências indispensáveis para ser discípulo de Jesus um estudo exegético-teológico de Lc 14,25-33." Pontifícia Universidade Católica de São Paulo, 2017. https://tede2.pucsp.br/handle/handle/20333.
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Submitted by Filipe dos Santos (fsantos@pucsp.br) on 2017-09-01T13:12:16Z
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
The gospel according to Luke, in the extended section of Jesus' ascent to Jerusalem (Lk 9:51–19:28), presents the conditions cited by Jesus for one to become his disciple. The purpose of this dissertation is to examine each of these conditions by focusing specifically on the text of Luke 14:25-33. To do so, an exegetical analysis of the text will be developed, which will serve as a basis for a subsequent theological analysis and consequent hermeneutic actualization. The theme is relevant, since discipleship has been and remains the essence of the Christian life in the sense of a godly life in community. The methodology applied in this work will be guided by a bibliographical research, which will be based on several authors, who have developed studies and research on the subject. The conditions put forward by Jesus, presented in the Lucan text, express the radicality and the necessity of a conscious decision on the position that will be adopted before them. From these factors will depend a genuine position as a disciple of Jesus Christ, who obeys and follows
O evangelho segundo Lucas, na extensa seção da subida de Jesus a Jerusalém (Lc 9,51–19,28), apresenta as condições citadas por Jesus para que alguém se torne seu discípulo. O objetivo da presente dissertação é examinar cada uma dessas condições, focalizando especificamente o texto de Lc 14,25-33. Para tanto será desenvolvida uma análise exegética do texto que servirá de base para uma posterior análise teológica e uma consequente atualização hermenêutica. O tema é relevante, uma vez que o discipulado foi e continua sendo a essência da vida cristã, no sentido de uma vida piedosa em comunidade. A metodologia aplicada neste trabalho se orientará por uma pesquisa bibliográfica, que tomará por base diversos autores que desenvolveram estudos e pesquisas sobre o tema. As condições apresentadas por Jesus e narradas no texto lucano expressam a radicalidade e a necessidade de uma decisão consciente quanto ao posicionamento que, diante delas, se adotará. Delas dependerá o seguimento genuíno do discípulo de Jesus Cristo
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Almeida, Filho Victor da Silva. "Σπλαγχνίζομαι: expressão do amor entranhado de Deus: uma leitura exegético-teológica de Lc 7,11-17." Pontifícia Universidade Católica de São Paulo, 2017. https://tede2.pucsp.br/handle/handle/20447.
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Submitted by Filipe dos Santos (fsantos@pucsp.br) on 2017-09-29T12:34:58Z
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Victor da Silva Almeida Filho.pdf: 1453247 bytes, checksum: 440494c02418fcfa50c70b51c2a54830 (MD5)Made available in DSpace on 2017-09-29T12:34:58Z (GMT). No. of bitstreams: 1 Victor da Silva Almeida Filho.pdf: 1453247 bytes, checksum: 440494c02418fcfa50c70b51c2a54830 (MD5) Previous issue date: 2017-09-19
Pontifícia Universidade Católica de São Paulo - PUCSP
This study is an analysis of the account of Luke 7, 11-17 better known as the resurrection of the son of the widow of Naim. In a first moment the work deals with general questions of the Gospel according to Luke, presenting the structural analyzes of the narrative. So, the pericope of Naim assumes a literary function, serving to complete the answer to the messengers sent by John the Baptist (Lk 7, 18-23) about the identity of Jesus. To prove this, Luke employs the Greek verb σπλαγχνίζομαι, to be moved with compassion, to a widowed woman who was in a situation of vulnerability. We studied the rule for the use of this verb in the pericope as well as its semantic root and its two other occurrences in the Lucan Gospel. For the analysis and interpretation of Lk 7,11-17, analytical elements of contemporary biblical exegetical methodology were used. The research valorized the diachronic studies by making the interface with the synchronic studies and intertextual analyzes, aided by texts of the Magisterium of Pope Francis. The results achieved were a better understanding of the Lucan account, because in using the verb σπλαγχνίζομαι the author does so in a conscious and coherent way towards those who are in a situation of vulnerability and uses their own literary criteria and their particular narrative style
Este estudo é uma análise do relato de Lc 7,11-17, mais conhecido como a ressurreição do filho da viúva de Naim. Em um primeiro momento, o trabalho trata de questões gerais do Evangelho segundo Lucas, apresentando as análises estruturais da narrativa. A perícope de Naim assume uma função literária, completando a resposta aos mensageiros enviados por João Batista (Lc 7,18-23) sobre a identidade de Jesus. Para demosntrar isso, Lucas emprega o verbo grego σπλαγχνίζομαι, “ser movido de compaixão”, para uma mulher viúva que se encontrava em situação de vulnerabilidade. Foram estudados os critérios para o emprego deste verbo na perícope, bem como sua raiz semântica e suas duas outras ocorrências no Evangelho lucano. Para a análise e interpretação de Lc 7,11-17 foram utilizados elementos analíticos da metodologia exegética bíblica contemporânea. A pesquisa valorizou os estudos diacrônicos, fazendo a interface com os estudos sincrônicos e análises intertextuais, auxiliados por textos do Magistério. Os resultados alcançados foram uma melhor compreensão do relato lucano, pois, ao empregar o verbo σπλαγχνίζομαι, o autor o faz de modo consciente e coerente para com os que se encontram em situação de vulnerabilidade e se vale de critérios literários próprios e de seu particular estilo narrativo
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Diagre, Denis. "Le jardin botanique de Bruxelles (1826-1912): miroir d'une jeune nation." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210873.
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Calderon, Molina Angie Dayan. "Application of Human Glycosyltransferases in N-glycan Synthesis and Their Substrate Specificity Studies." 2016. http://scholarworks.gsu.edu/chemistry_diss/128.
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Glycoscience is important in many areas such as human health, energy and material science. Glycans have been shown to be involved in the pathophysiology of almost every major disease. Additional glycan structure knowledge is required to help advance personal medicine, and pharmaceutical developments, among others. For glycoscience to advance there is a need for large quantities of well-defined glycans and have quick access to glycosyltransferases for manipulating glycan synthesis.
Herein, we will cover our efforts on studying the substrate specificities of human glycosyltransferases such as FUT8 and Gn-T V, and their application on N-glycan synthesis. Complex asymmetric N-glycan isomer structures have been related to many diseases such as breast cancer, among others. Synthesis of complex asymmetric N-glycan isomer structures including: alpha-1,6 core-fucosylated, and tri-antennary structures can be achieved by taking advantage of the high specificity of glycosyltransferases that can work as unique catalyst to generate well-defined glycan structures.
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Haslebacher, Christian. "Bedeutung und hermeneutischen Implikationen der Verweise auf die Schöpfungsordnung und den Fall Evas in 1. Timotheus 2." Diss., 2012. http://hdl.handle.net/10500/9942.
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German textNach grundsätzlichen Überlegungen zur Allgemeingültigkeit, Kultur- und Zeitbezo-genheit neutestamentlicher Aussagen untersucht die vorliegende Studie das Lehrver-bot der Frauen im gesamtbiblischen Kontext. Dadurch resultiert 1. Timotheus 2:12-14 als Schlüsseltext in der Frage, ob Frauen für den leitenden und lehrenden Dienst in der Gemeinde zugelassen sind. Hinweise für das richtige Verständnis von 1. Ti-motheus 2:12-14 sind Vergleiche mit anderen paulinischen Verweisen auf erzählte Ereignisse des Alten Testaments und ihre Funktion im jeweiligen Diskurs, die Wir-kungsgeschichte der Schöpfungsreihenfolge und von Evas Fall im Frühjudentum sowie die Funktion dieser Verweise in der Argumentation im 1. Timotheusbrief. Ab-schliessend wird 1. Timotheus 2:12-14 im Bezug auf den unmittelbaren Kontext un-tersucht. Die vorliegende Arbeit schließt, dass 1. Timotheus 2:12-14 trotz der Ver-weise auf die Schöpfungsreihenfolge und den Fall Evas nicht als allgemeingültig zu verstehen ist.
After general reflections on universal validity, and on the cultural and temporal set-ting of New Testament propositions, this study examines the prohibition on women teaching in Christian congregations in the context of the whole Biblical canon. From this perspective, 1 Timothy 2:12-14 offers a key role for the validity of women as leaders and teachers. Clues towards a correct understanding of 1 Timothy 2:12-14 are to be found in comparisons with references to Old Testament events and their par-ticular function in Pauline discourse, in reception of the order of creation and fall of Eve in early Judaism, and in the function of these references in the argument of 1 Timothy. Finally, 1 Timothy 2:12-14 is examined in view of its immediate context. The thesis concludes that, despite its reference to the order of creation and the fall of Eve, 1 Timothy 2:12-14 should not be understood as an absolute prohibition.
New Testament
M. Th. (New Testament)
Books on the topic "N.T. Luke II"
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Barton, Bruce B. Luke. Edited by Veerman David, Taylor Linda Chaffee 1958-, and Osborne Grant R. Wheaton, Ill: Tyndale House Publishers, 1997.
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Parsons, Mikeal C. Luke: Storyteller, interpreter, evangelist. Waco, Texas: Baylor University Press, 2014.
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Luke: The NIV application commentary from biblical text--to contemporary life. Grand Rapids, Mich: Zondervan Pub. House, 1996.
Find full textBook chapters on the topic "N.T. Luke II"
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Pardasani, R. T., and P. Pardasani. "Magnetic properties of N, N′-bis(3-t-butyl-2-hydroxy-5-methylbenzyliden)-1, 7-diamino-4-methyl-4-azaheptano-cobalt(II)." In Magnetic Properties of Paramagnetic Compounds, 606–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_311.
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Bréchon, Geneviève. "BERNARD BRUSSET, « Anorexie et toxicomanie » (1984),Adolescence, t. II, n˚ 2, 1984 ,285-314." In 45 commentaires de textes en psychopathologie psychanalytique, 363. Dunod, 2012. http://dx.doi.org/10.3917/dunod.chagn.2012.02.0363.
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"237 Quintillas del mismo que se cantaron lunes, p e n ú l t i m o día del Novenario." In Obras completas, Vol. I y II, 1226–27. Vervuert Verlagsgesellschaft, 2001. http://dx.doi.org/10.31819/9783865279217-086.
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Dickens, Charles. "I, 379.18. Replaces Extract (Aa) (Vol. II, P. 94) To T. N. Talfourd, [?Late February 1838]." In The British Academy/The Pilgrim Edition of the Letters of Charles Dickens, Vol. 12: 1868–1870, edited by Graham Storey. Oxford University Press, 2002. http://dx.doi.org/10.1093/oseo/instance.00121067.
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"ANHANG II. AUSZUG AUS : JOHANN ANDREAS FRH. V. EICHHOFF, V O N MIRAMAR NACH S T . GERMAIN." In Theodor Ritter von Zeynek, 317–28. Wien: Böhlau Verlag, 2009. http://dx.doi.org/10.7767/9783205118756-008.
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HEBERLÊ DE ALMEIDA, LIVIA, and JULIO CESAR BRESOLIN MARINHO. "LIVRETO DE RECURSOS DIDÁTICOS PARA O ENSINO DE CIÊNCIAS E BIOLOGIA." In Itinerários de resistência: pluralidade e laicidade no Ensino de Ciências e Biologia. Editora Realize, 2021. http://dx.doi.org/10.46943/viii.enebio.2021.01.340.
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"LIVRETO DE RECURSOS DID?TICOS PARA O ENSINO DE CI?NCIAS E BIOLOGIANOS DIAS ATUAIS, N?S PROFESSORES, ESTAMOS CONSTANTEMENTE PROCURANDO FORMAS DE OTIMIZAR NOSSAS AULAS E FAZER COM QUE OS CONTE?DOS ENSINADOS GANHEM MAIS SENTIDO E SIGNIFICADO PARA OS ALUNOS. GUIMAR?ES (2009, P. 13) EVIDENCIA A IMPORT?NCIA DE UMA ?METODOLOGIA DE ENSINO QUE TENHA EM VISTA A COMPLEXIDADE E A DIVERSIDADE DAS CI?NCIAS NATURAIS E QUE N?O ESTEJA RESTRITA ? SIMPLES MEMORIZA??O?. A PARTIR DESSA EVID?NCIA PODEMOS NOS QUESTIONAR: EXISTE UMA METODOLOGIA ?NICA PARA UTILIZARMOS EM NOSSAS AULAS? A RESPOSTA ? NEGATIVA, POIS O QUE EXISTE S?O METODOLOGIAS (NO PLURAL) ADEQUADAS PARA DETERMINADOS CONTEXTOS E SITUA??ES. ATRELADA A QUEST?O METODOL?GICA, TEMOS O DESAFIO DE COLOCAR O SABER CIENT?FICO (T?O VALORIZADO ATUALMENTE) AO ALCANCE DO P?BLICO ESCOLAR, O QUAL ? VASTO E HETEROG?NEO, VISTO QUE ATUALMENTE ? REPRESENTADO ?POR TODOS OS SEGUIMENTOS SOCIAIS E COM MAIORIA EXPRESSIVA ORIUNDA DE CLASSES E CULTURAS QUE AT? ENT?O N?O FREQUENTARAM A ESCOLA? (DELIZOICOV, ANGOTTI E PERNAMBUCO, 2011, P. 33). TENDO ESSE P?BLICO PLURAL EM NOSSAS SALAS DE AULA, EVIDENCIAMOS A DEMANDA DE PENSAR EM VARIADAS ESTRAT?GIAS DID?TICAS PARA CONTEMPLAR ESSES DIFERENTES PERFIS. DELIZOICOV, ANGOTTI E PERNAMBUCO (2011) NOS AUXILIAM A COMPREENDER QUE UMA DAS FUN??ES DA ESCOLA ? PREPARAR PARA O EXERC?CIO CONSCIENTE DA CIDADANIA, N?O SENDO POSS?VEL QUE SEU ENSINO N?O SEJA PERMEADO PELAS POSSIBILIDADES DO CONHECIMENTO CIENT?FICO. OS AUTORES COMPREENDEM TAMB?M QUE DIVERSAS QUEST?ES EXTRAPOLAM O ?MBITO EXCLUSIVO DAS CI?NCIAS NATURAIS E N?O PODEM SER ENFRENTADAS SEM OUTROS CONHECIMENTOS. DESSA FORMA, NA TENTATIVA DE FORNECER MAIS SIGNIFICADO AOS CONTE?DOS TRABALHADOS EM SALA DE AULA, ATENDER A UMA MAIOR DIVERSIDADE DE ALUNOS E AUXILI?-LOS NO EXERC?CIO DA CIDADANIA APOSTAMOS NA UTILIZA??O DE RECURSOS DID?TICOS DIVERSIFICADOS PARA POTENCIALIZAR O ENSINO. NESTE SENTIDO, A PROFESSORA DO COMPONENTE CURRICULAR DE PR?TICAS FORMATIVAS E EDUCATIVAS II (PFE II), DO CURSO DE LICENCIATURA EM CI?NCIAS BIOL?GICAS DA UNIVERSIDADE FEDERAL DO PAMPA (UNIPAMPA) ? CAMPUS S?O GABRIEL, RS, BRASIL, JUNTAMENTE COM O PROFESSOR COORDENADOR DO PROJETO DE ENSINO ?MODALIDADES DID?TICAS ALTERNATIVAS PARA O ENSINO DE CI?NCIAS E BIOLOGIA?, CADASTRADO NA UNIVERSIDADE, ORGANIZARAM ATIVIDADES PARA ATENDER AS DEMANDAS QUE SE COLOCAM NA FORMA??O INICIAL E CONTINUADA DE PROFESSORES. O PROJETO DE ENSINO, EST? VINCULADO AO COMPONENTE CURRICULAR PR?TICAS FORMATIVAS E EDUCATIVAS II. DESSA FORMA, AS ATIVIDADES INICIARAM NO ?MBITO DO COMPONENTE, CONTANDO COM AS SEGUINTES ATIVIDADES: ESTUDO, LEITURA E DISCUSS?O DE TEXTOS SOBRE M?TODOS E T?CNICAS DE ENSINO; APROFUNDAMENTO DAS FORMAS DE SE ORGANIZAR/PLANEJAR O ENSINO; PLANEJAMENTOS E DESENVOLVIMENTO DE ATIVIDADES ALTERNATIVAS COM CONTE?DOS/TEMAS DAS CI?NCIAS BIOL?GICAS; ELABORA??O DE MATERIAIS DID?TICOS, AVALIA??O DOS MATERIAIS PRODUZIDOS, ELABORA??O DO LIVRETO E REALIZA??O DE UM WORKSHOP PARA PROFESSORES DA EDUCA??O B?SICA DO MUNIC?PIO DE S?O GABRIEL, RS. NO QUADRO ABAIXO PODE-SE OBSERVAR AS ETAPAS DO PROJETO, RESPONS?VEIS PELAS A??ES E O PER?ODO DE REALIZA??O: ETAPA ATIVIDADES RESPONS?VEIS PER?ODO 1? LEITURA E DISCUSS?O DE TEXTOS SOBRE M?TODOS E T?CNICAS DE ENSINO PROFESSORA PFE II E ALUNOS AGOSTO 2019 2? APROFUNDAMENTO DAS FORMAS DE SE ORGANIZAR/PLANEJAR O ENSINO PROFESSORA PFE II E ALUNOS AGOSTO 2019 3? PLANEJAMENTOS DE ATIVIDADES ALTERNATIVAS COM CONTE?DOS/TEMAS DAS CI?NCIAS BIOL?GICAS PROFESSORA PFE II E ALUNOS SETEMBRO 2019 4? ELABORA??O DE RECURSOS DID?TICOS ALUNOS SETEMBRO 2019 5? AVALIA??O DOS RECURSOS PRODUZIDOS ALUNOS OUTUBRO 2019 6? ELABORA??O DE LIVRETO ALUNOS OUTUBRO 2019 7? ORGANIZA??O DO LIVRETO PROFESSORA PFE II E PROFESSOR COORDENADOR DO PROJETO NOVEMBRO 2019 8? ORGANIZA??O DO WORKSHOP PROFESSOR COORDENADOR DO PROJETO E PROFESSORA PFE II NOVEMBRO 2019 9? REALIZA??O DE WORKSHOP PARA PROFESSORES DA EDUCA??O B?SICA DO MUNIC?PIO PROFESSOR COORDENADOR DO PROJETO, PROFESSORA PFE II E ALUNOS DEZEMBRO 2019 10? AVALIA??O DO WORKSHOP PELOS ORGANIZADORES, SEGUNDA OS FORMUL?RIOS DE AVALIA??O DOS LICENCIANDOS EM CI?NCIAS BIOL?GICAS E PROFESSORES DA EDUCA??O B?SICA PARTICIPANTES DO EVENTO PROFESSOR COORDENADOR DO PROJETO E PROFESSORA PFE II DEZEMBRO 2019 JANEIRO 2020 NA ETAPA 1, OS ALUNOS PARTICIPARAM DE ATIVIDADES EM AULA QUE ENVOLVIAM O ESTUDO DIRIGIDO DE TEXTOS E DISCUSS?ES SOBRE RECURSOS DID?TICOS. KRASILCHIK (2004) DEFENDE A UTILIZA??O DA MODALIDADE DID?TICA DISCUSS?O, POIS ATRAV?S DELA H? TRANSI??O DE UMA AULA EM QUE SOMENTE O PROFESSOR FALA, PARA UMA A QUAL EXISTE O DI?LOGO ENTRE TODAS AS PARTES. A DISCUSS?O ESTRUTURADA E ORIENTADA, POSSIBILITOU UMA TROCA DE CONHECIMENTOS E REFLEX?O CR?TICA DOS ALUNOS SOBRE O PAPEL DA UTILIZA??O DE RECURSOS DID?TICOS NO ENSINO DE CI?NCIAS E BIOLOGIA. POSTERIORMENTE, NAS ETAPAS 2 E 3, OS ALUNOS ESTIVERAM ENVOLVIDOS EM ATIVIDADES DE APROFUNDAMENTO TE?RICO SOBRE AS ?MODALIDADES DID?TICAS? (KRASILCHIK, 2004). TAIS ETAPAS VISARAM COMPREENDER E AUXILIAR OS ALUNOS NA ELABORA??O DE PLANEJAMENTOS DE AULA CONTEMPLANDO A INSER??O DE RECURSOS DID?TICOS. LIB?NEO (1994, P. 22) DESTACA A IMPORT?NCIA DO PLANEJAMENTO POR TRATAR-SE DE ?UM PROCESSO DE RACIONALIZA??O, ORGANIZA??O E COORDENA??O DA A??O DOCENTE?. A ETAPA 4, FOI O MOMENTO DEDICADO A ELABORA??O DOS RECURSOS DID?TICOS PELOS ALUNOS. A DEFINI??O DAS TEM?TICAS E/OU CONCEITOS TRABALHADOS POR CADA GRUPO ERA DE ESCOLHA LIVRE, PARTINDO DE SEU TEMA DE INTERESSE. NESSE CONTEXTO, ALGUNS ALUNOS OPTARAM POR ELABORAR MODELOS DID?TICOS, OUTROS CRIARAM JOGOS. ESTE MOMENTO DE IMERS?O DOS ALUNOS POSSIBILITOU ENVOLVIMENTO E MOTIVA??O PARA ELABORA??O DOS RECURSOS DID?TICOS, VISTO QUE SENTIRAM A NECESSIDADE DE PROCURAR INFORMA??ES EM DIFERENTES FONTES, EXPLORANDO A SUA CRIATIVIDADE. BUSCARAM TAMB?M CONTEMPLAR ASPECTOS REGIONAIS (BIOMA PAMPA) E VIABILIZAR A PRODU??O DE TAIS RECURSOS PELOS PROFESSORES (FACILIDADE DE TRANSPORTE E MATERIAIS DE BAIXO CUSTO). A PARTICIPA??O ATIVA DOS ALUNOS TORNOU-OS PROTAGONISTAS NO PROCESSO DE APRENDIZAGEM. DE ACORDO COM COSTA (2000) O PROTAGONISMO, ENQUANTO PARTICIPA??O GENU?NA RESULTA NUM GANHO DE AUTONOMIA, AUTOCONFIAN?A, AUTODETERMINA??O NA CONSTRU??O DA IDENTIDADE PESSOAL, SOCIAL E NO PROJETO DE VIDA. NA ETAPA 5 BUSCOU-SE ANALISAR OS RECURSOS PRODUZIDOS PELOS ESTUDANTES DIALOGANDO COM OS TEXTOS E FUNDAMENTOS TE?RICOS ABORDADOS NA DISCIPLINA. NESTE MOMENTO FOI POSS?VEL REFLETIR SOBRE A ELABORA??O E, POR MEIO DE SUGEST?ES DO GRUPO, APERFEI?OAR AS PROPOSTAS. AO FINAL DESTAS ETAPAS PENSOU-SE EM ELABORAR UM LIVRETO CONTEMPLANDO OS RECURSOS PRODUZIDOS NA DISCIPLINA. O INTUITO DESSE MATERIAL RESIDIA EM SOCIALIZAR A CONSTRU??O DOS LICENCIANDOS E DISPONIBILIZAR, AOS PROFESSORES DA EDUCA??O B?SICA DE S?O GABRIEL, UM MATERIAL COM SUGEST?ES PARA O ENSINO DE CI?NCIAS E BIOLOGIA. ASSIM, NA ETAPA 6 OCORREU A ELABORA??O DO LIVRETO, ONDE CADA GRUPO FICOU RESPONS?VEL DE ESTRUTURAR O PLANEJAMENTO DO RECURSO ELABORADO, DE ACORDO COM OS CRIT?RIOS ESTABELECIDOS NO COMPONENTE CURRICULAR PFE II. POSTERIORMENTE A PROFESSORA DA DISCIPLINA, JUNTAMENTE COM O COORDENADOR DO PROJETO ORGANIZARAM O LIVRETO, UNINDO OS MATERIAIS DOS ALUNOS, ELABORANDO CAPA, PREF?CIO, APRESENTA??O E AS DEVIDAS FORMATA??ES. O LIVRETO (FIGURA 1) SOCIALIZA UM CONJUNTO DE RECURSOS DID?TICOS, ORGANIZADOS NA FORMA DE M?DULOS DE ATIVIDADES, VOLTADAS AO ENSINO DE CI?NCIAS E BIOLOGIA. OS M?DULOS EST?O ORGANIZADOS DA SEGUINTE FORMA: INTRODU??O, OBJETIVOS, MATERIAIS E EXPLORA??O DID?TICA. AL?M DO LIVRETO, COM O AUX?LIO DE UM DOS ALUNOS, FOI ELABORADO UM BLOG QUE APRESENTA ALGUNS RECURSOS DE FORMA MAIS DETALHADA, COM OP??ES DE IMPRESS?ES DE JOGOS E MATERIAIS. FIGURA 1: CAPA DO LIVRETO PRODUZIDO OS RECURSOS DISPONIBILIZADOS NO LIVRETO ABORDAVAM AS SEGUINTES TEM?TICAS: R?PTEIS, C?LULAS, BACT?RIAS, PIR?MIDE ALIMENTAR, SISTEMA GENITAL, SISTEMA DIGESTIVO, SISTEMA CIRCULAT?RIO, SISTEMA IMUNOL?GICO, SISTEMA ARTICULAR E SISTEMA SOLAR. NESTA PERSPECTIVA, FOI ORGANIZADO UM WORKSHOP PARA PROFESSORES DA EDUCA??O B?SICA DO MUNIC?PIO (ETAPA 8), A FIM DE SOCIALIZAR OS JOGOS E RECURSOS DID?TICOS PRODUZIDOS. DADOS OBTIDOS NA AVALIA??O (ETAPA 9) TANTO DOS PROFESSORES PARTICIPANTES, COMO DOS ALUNOS DA LICENCIATURA EM CI?NCIAS BIOL?GICAS DA UNIPAMPA APRESENTAVAM QUE O EVENTO TINHA ALCAN?ADO O SEU OBJETIVO. PALAVRAS CHAVE: ENSINO DE CI?NCIA, ENSINO DE BIOLOGIA, RECURSO DID?TICO, JOGO DID?TICO, FORMA??O DE PROFESSORES. AGRADECIMENTOS AOS ALUNOS DO CURSO DE LICENCIATURA EM CI?NCIAS BIOL?GICAS DA UNIPAMPA PELO EMPENHO NA ELABORA??O DOS RECURSOS. AOS ALUNOS E PROFESSORES DO CAMPUS S?O GABRIEL DA UNIPAMPA QUE COLABORARAM COM A REALIZA??O DO WORKSHOP. AOS PROFESSORES DA EDUCA??O B?SICA DE S?O GABRIEL PELA ACOLHIDA E PARTICIPA??O NO WORKSHOP. REFER?NCIAS COSTA, A. C. G. PROTAGONISMO JUVENIL: ADOLESC?NCIA, EDUCA??O E PARTICIPA??O DEMOCR?TICA. SALVADOR: FUNDA??O ODEBRECHT, 2000. DELIZOICOV, D.; ANGOTTI, J. A.; PERNAMBUCO, M. M. ENSINO DE CI?NCIAS: FUNDAMENTOS E M?TODOS. 4 ED. S?O PAULO: CORTEZ, 2011. GUIMAR?ES, LUCIANA RIBEIRO. ATIVIDADES PARA AULAS DE CI?NCIAS: ENSINO FUNDAMENTAL, 6? AO 9? ANO. S?O PAULO: NOVA ESPIRAL, 2009. KRASILCHIK, M. 2004. PR?TICA DO ENSINO DE BIOLOGIA. EDITORA EDUSP, 2004. LIB?NEO; J. C. DID?TICA. S?O PAULO: CORTEZ, 1994."
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Lambert, Tristan H. "Functional Group Protection." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0014.
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Alfonso Iadonisi at the University of Naples Federico II developed (Eur. J. Org. Chem. 2013, 3137) a procedure for the selective acetolysis of the perbenzylated sugar 1 to furnish 3 using isopropenyl acetate (2) instead of the more typical and high-boiling acetic anhydride. The (3,4-dimethoxylphenyl)benzyl (DMPBn) protecting group, which is removed (cf. 4 → 5) under acidic conditions in the presence of the cation scavenger 5, was developed (J. Org. Chem. 2013, 78, 5264) by David S. Larsen at the University of Otago as an alternative to the p-methoxybenzyl (PMB) group. Another new hydroxyl-protecting group, the AzDMB group, which can be installed by simple acylation of (7 + 8 → 9) and removed under reductive conditions, was developed by Gijsbert A. van der Marel and Jeroen D.C. Codée of Leiden University. Stefan Grimme at the University of Bonn and Armido Studer at Westfälische-Wilhelms-Universität Münster found (Chem. Sci. 2013, 4, 2177) that NHC precatalyst 11 in the presence of NaH, benzaldehyde, and the oxidant 12 allows for the selective O-acylation of aminoalcohol 10 to 13. The reductive deprotection of benzyl carbamate 14 using the strong organic reductant 15 under photolytic conditions was achieved (Angew. Chem. Int. Ed. 2013, 52, 2239) by John A. Murphy at the University of Strathclyde. Liang-Qiu Lu and Wen-Jing Xiao at Central China Normal University found (Chem. Asian J. 2013, 8, 1090) that mixed imide 17 could be detosylated under visible light photoredox catalysis in the presence of Hantzsch ester 18. Frank Glorius at Westfälische-Wilhelms-Universität Münster developed (Org. Lett. 2013, 15, 1776) a ruthenium-catalyzed procedure for the N-formylation of amine 20 using methanol as the source of the formyl group. Protection of the thymine derivative 22 with a 2-(methoxycarbonyl)ethenyl (MocVinyl) group to produce 23 was developed (J. Org. Chem. 2013, 78, 5832) by Jaume Vilarrasa at the University of Barcelona. Deprotection of the MocVinyl group is readily achieved by treatment with a nucleophilic reagent such as pyrrolidine. Robert H. Grubbs at Caltech demonstrated (Chem. Sci. 2013, 4, 1640) that ether 24 could be demethylated with triethylsilane and potassium t-butoxide at high temperatures.
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Tarnowski, Karol. "Wolność u Wojtyły i Tischnera." In Horyzonty wolności, 103–14. Uniwersytet Papieski Jana Pawła II w Krakowie. Wydawnictwo Naukowe, 2019. http://dx.doi.org/10.15633/9788374388320.10.
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Both for Karol Wojtyła, the future Pope John Paul II, and Józef Tischner, freedom is a key matter. However, freedom must be e x p e r i e n c e d ; it is not revealed in objective metaphysics or in science.For Wojtyła, it is an experience of the moral a c t : freedom is a condition and in-gredient of the moral act and responsibility for it. It enters into the composition of the essential structure of the person, which means “self-restraint,” or shaping oneself through free choices. Freedom has the power to create man through itself: referring to others in morality, I at the same time refer to myself, deciding who I will be. This existential weight of freedom – responsibility for oneself before others, God, and oneself – is the price of freedom which, let us add, is inevitable. Even the rejection of freedom or resignation from it is still an expression of freedom. For Wojtyła, freedom shapes man through an instinc-tive, completely not induced reference to the truth about values. However, in this reference and in acting the subject is dependent only on itself. The weight of the action, whose truth we decipher in our conscience, is what most impresses Wojtyła. The lack of a need for the concept of grace in this vision is striking. The subject is independent, autonomous, and thus responsible. With regards to this point, Wojtyła is close to Thomism and its respect for the innateness of creation.For Tischner, freedom is key and is also an innate value that is experienced. Its essence is above all freeing, liberating; thus Tischner does not hesitate to discern it in extra-moral phenomena such as dancing, which liberates beauty, and even extra-human ones, such as the beauty of an elk jumping across a brook. Beauty and good require freedom. However, the true liberation of freedom is opening oneself to the freedom of the other in encoun-ter, as thanks to this I can enter into a relationship of love and fidelity; I can s a c r i f i c e myself and through this fulfill the highest act of freedom, an act that is not induced by pre-established responsibility for the other, as in Levinas’ philosophy. Although it is not induced, this act assumes in an essential way the relationality of the subject and at the same time its finiteness.
Conference papers on the topic "N.T. Luke II"
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Horsley, Roger, Yoshifumi Nakamura, Dirk Pleiter, Paul E. L. Rakow, Gerrit Schierholz, Hinnerk Stüben, F. Winter, and James M. Zanotti. "Hyperon Structure from N[sub f] = 2+1 Lattice QCD." In T(R)OPICAL QCD II WORKSHOP. AIP, 2011. http://dx.doi.org/10.1063/1.3587593.
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Garzon, C. Karen E., and F. Jose L. Rubiano. "Diseño e implementación de un prototipo de ortesis para prevención y tratamiento del Síndrome del Túnel del Carpo (STC)." In 2013 II International Congress of Engineering Mechatronics and Automation (CIIMA). IEEE, 2013. http://dx.doi.org/10.1109/ciima.2013.6682794.
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Garcia Frade, L. J., L. Landin, A. Garcia Avello, J. L. Bavarro, L. J. Creighton, and P. J. Gaffney. "FIBRIIOLYTIC ACTIVITY II THE IITBISIVE CARE PATIEIT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644885.
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Critically ill patients have been described to have blood coagulation abnormalities that predispose to bleeding and thrombosis.We have studied plasminogen activators (fibrin plate, enzyme-linked Immunosorbent assay using polyclonalantibodies for t-PA), X-oligomers fibrin fragments (using monoclonal antibodies in an enzyme-linked immunosorbent assay), octant i pi asmin, antithrombtai III and fibronectin (Laurel1 innaunoeleetrophoretic technique), fibrinogen (thrombin timeassay), plateLets count, kaolln-cephalin clotting time and prothrombin time on admission to the intensive care unit and sequentially after 24 and 48 hours in 39 adult patients: Adult respiratory distress syndrome (ARDS) (n:6), Trauma (n:12), Sepsis (n:8), and Miscellanea (n:13).A decrease in tissue plasminogen activator (ng/ml)(p<0.001, p<0.05, p<0.01, p<0.05, respectively in the four groups), associated to an increase in the earliest form of cross-linked fibrin degradation products, X-Oligomers concentration (ng/ml) (p<0.01), indicatethat fibrindeposition and fibrinolytic exhaustion is a widespread situation in the ICU patients. Fibronectin was significantly reduced (p<0.001) in ARDS and Sepsis patients, low fibronectin levels were related to prognosis (p<0.01).These findings suggest.that critically ill patients, must be evaluated in respect to fibrinolysis and supported when necessary with prophylactic treatment.
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Pereira, Vanessa de Brito, Gessilda De Alcantara Nogueira De Melo, Débora De Mello Gonçales Sant’ana, and Jaqueline De Carvalho Rinaldi. "INFECÇÃO CRÔNICA POR TOXOPLASMA GONDII ALTERA O NÚMERO DE FOLÍCULOS OVARIANOS EM CAMUNDONGOS C57BL/6." In II Congresso Brasileiro de Saúde On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1423.
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Introdução: Toxoplasmose é uma parasitose de ampla distribuição causada pelo Toxoplasma gondii. Esta zoonose pode causar abortos em várias espécies, além de desencadear alterações neurológicas e oculares, porém sabe-se pouco sobre seus efeitos nos órgãos da reprodução. Objetivo: Investigar o impacto da infecção crônica pelo T. gondii sobre a quantificação dos folículos ovarianos em camundongos adultos. Material e métodos: Camundongos c C57BL/6 fêmeas foram separadas nos grupos controle (GC, n=8) e infectado (GI, n=8). Enquanto o GC recebeu salina, o GI recebeu 1000 oocistos por gavagem para indução da infecção experimental (protocolo aprovado pela CEUA/UEM sob nº 4092040517). Após 60 dias houve análise do ciclo estral dos animais pelo smear vaginal e foram eutanasiados aqueles que se encontravam em estro, fase caracterizada pela presença de células epiteliais queratinizadas. Após o aprofundamento anestésico com vapor de isoflurano os eutanasiados tiveram os ovários dissecados, pesados, processados e incluídos em parafina. Cortes de 5µm foram corados em Hematoxilina-eosina para análise da morfologia geral da gônada e quantificação dos folículos ovarianos. Os resultados foram submetidos ao teste estatístico t student e considerados significativos quando p<0,05. Resultados: A infecção crônica pelo T. gondii não afetou o peso corpóreo ou do ovário dos animais. A gônada de ambos os grupos apresentou uma organização similar, contendo região cortical constituída por epitélio germinativo, túnica albugínea, tecido conjuntivo e folículos ovarianos em diferentes estágios de desenvolvimento. A região medular apresentou-se organizada em tecido conjuntivo contendo feixe vásculo-nervoso glandular. A análise quantitativa evidenciou um aumento em 32% no número de folículos totais na cortical ovariana do GI em relação ao GC (p<0,001). Sabe-se que o T. gondii é capaz de reduzir significativamente o FSH e o LH tanto em homens quanto mulheres. Assim, uma hipótese que justifica o resultado encontrado é de que o parasito foi capaz de promover desregulação hormonal e assim afetar a maturação folicular ovariana e a ovulação. Conclusão: A infecção crônica pelo T. gondii afetou a quantidade de folículos presentes no córtex ovariano, demonstrando que a infecção pelo parasito pode afetar os estágios mais precoces da reprodução em camundongos C57BL/6 fêmeas.
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Jacobs, SA, A. Robidoux, JMP Garcia, J. Abraham, N. La Verde, JM Orcutt, ME Cazzaniga, et al. "Abstract PD5-04: NSABP FB-7: A phase II randomized trial evaluating neoadjuvant therapy with weekly paclitaxel (P) plus neratinib (N) or trastuzumab (T) or neratinib and trastuzumab (N+T) followed by doxorubicin and cyclophosphamide (AC) with postoperative T in women with locally advanced HER2-positive breast cancer." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-pd5-04.
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Church, F. C., R. E. Treanor, and H. C. Whinna. "ACTIVATION OF HEPARIN COFACTOR II BY PHOSVITIN, A PHOSPHOGLYCO-PROTEIN, AND OTHER PHOSPHATE-CONTAINING POLYANIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643867.
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We are characterizing the specificity of the polyanion-binding domain of the heparin/dermatan sulfate-dependent plasma protease inhibitor, heparin cofactor II (HCII). Various phosphate-containing polyanions accelerate the HCII-catalyzed inhibition of thrombin (T). Phosvitin, a phosphoprotein, enhances the HCII/T reaction at 25°C and pH 8.0 with the apparent second-order rate constant value (K2) increasing from 5 × 104 M−1 min−1 (in the absence of phosvitin) to 8 x 10' M”1 min as phosvitin increased from 0.05 to 30 ug/ml and then decreases as phosvitin is increased above 30 ug/ml. Apparent dissociation constant values for phosvitin-HCII and phosvitin-T are 450 nM and 10 nM, respectively. Polynucleotides accelerate the HCII/T reaction and have the following specificity (concentrations examined from 1-200 ug/ml): poly(guanylic acid) >> poly(adeny-lic acid, guanylic acid) > poly(inosinic acid) > poly(guanylic acid, uridylic acid) > poly(uridylic acid) = poly(adenylic acid) > poly(cytidylic acid). Polyphosphate anions (phosphate chain length, n, ranging from 5-100) enhance the HCII/T reaction. When compared at an equimolar phosphate concentration (1 mM), the rate was saturated at n = 50 with a maximum V.2 of about 5 × 107 M−1 min−1. Ca2+ (or Mg2+)-phosvitin/polyphosphate anion complexes and salmon protamine-polynucleotide complexes have lost the ability to enhance the HCII/T reaction. Phospho-pyridoxylated-HCII (lysine modified), with greatly reduced heparin cofactor activity, has lost its accelerating effect with phosvitin, polynucleotides and the polyphosphate anions. None of the above mentioned polyphosphate-containing compounds are effective at accelerating either the HCII-catalyzed inhibition of chymotrypsin or the antithrombin Ill-catalyzed T reaction. Our results suggest that (i) HCII is activated by the multiple negative charges of phosphate polyanions but they alone are not sufficient; (ii) the effective phosphate polyanions must also possess a specific conformation for maximum activity; and (iii) the phosphoserine-containing protein, phosvitin, can serve as a "template" for HCII/T.
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Borges, Shirley Aparecida Azevedo, Ieda Carla Candido, Jaqueline Carvalho Rinaldi, and Joice Toracci Alves. "O DIABETES MELLITUS TIPO-I ALTERA A MORFOLOGIA DE GLÂNDULAS SALIVARES." In II Congresso Brasileiro de Saúde On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1428.
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Introdução: A diabetes mellitus tipo 1 (DMT1) é uma doença metabólica, caracterizada pela destruição das células beta pancreáticas, levando a hiperglicemia crônica. Nas glândulas salivares pode provocar danos teciduais e prejuízo na produção de saliva. Objetivo: Este estudo tem como objetivo investigar se o DM1 altera a morfologia das glândulas salivares parótida e sublingual e submandibular. Materiais e métodos: Foram distribuídos 12 ratos Wistar adultos (250g) nos grupos: controle ou NG (normoglicêmico, n=6) e diabético ou DM1 (n=6). O DM1 foi induzido por injeção endovenosa de estreptozootocina (55 mg/kg de peso corporal) sendo considerados diabéticos os animais com glicemia de jejum e pós-prandial ≥ 300 mg/dL. Os animais foram eutanasiados 30 dias após a indução. As glândulas salivares foram dissecadas, pesadas, desidratadas em etanol, diafanizadas em xilol e emblocadas em parafina. Cortes de 5um foram corados em hematoxilina e eosina para análise histopatológica. O método de Weibel foi utilizado para analisar a proporção entre os compartimentos glandulares. Os dados foram submetidos a análise estatística pelo teste t e foi considerado significativo valores de p<0,05. Resultado: Dentre os principais resultados encontrados, pode-se listar a perda de polaridade das células epiteliais, vacuolização celular e diferença de distribuição entre os compartimentos glandulares. Conclusão: Conclui-se que o DM-1 alterou a morfológicas dos acinos e ductos das glândulas salivares.
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Gavin, PG, PS Kim, C. Lipchick, E. Langley, H. Feng, GR Meyer, S. Rim Kim, et al. "Abstract P1-07-12: An exploratory correlative biomarker analysis of NSABP FB-7, a phase II randomized trial evaluating neoadjuvant therapy with weekly paclitaxel (P) plus neratinib (N) or trastuzumab (T) or neratinib and trastuzumab (N+T) followed by doxorubicin and cyclophosphamide (AC) with postoperative T in women with locally advanced HER2-positive breast cancer." In Abstracts: 2016 San Antonio Breast Cancer Symposium; December 6-10, 2016; San Antonio, Texas. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.sabcs16-p1-07-12.
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Grant, M. B., T. Daniels, D. Claire, and R. Lottenberg. "DIABETICS DEMONSTRATE A BLUNTED VON WILLEBRAND FACTOR RESPONSE TO DESMOPRESSIN INFUSION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644130.
Full textAbstract:
The increase in von Willebrand factor (vWF) following desmopressin (DDAVP) (1-desamino-8-D-arginine vasopressin) infusion was markedly blunted in severe hemophiliacs who had high vWF levels after treatment with vWF rich plasma concentrates. Diabetics with microangiopathy appear to have disease-induced elevation of vWF. In the current study, the vWF response to DDAVP infusion was measured in 30 diabetics (12 type I, 18 type II) and 16 controls, matched for age, sex and weight. Extent of nephropathy, macroangiopathy, and neuropathy was evaluated. Diabetic retinopathy was assessed by indirect ophthalmoscopy and fluorescein angiography (n=8 proliferative retinopathy, n=6 background retinopathy, n=16 no retinopathy). Plasma samples were collected in the supine, overnight-fasted state. DDAVP (0.3 μg/kg) was infused over 30 min and samples obtained at 0-60 min. vWF antigen was assayed by Laurell rocket electrophoresis. Tissue plasminogen activator (t-PA) activity was measured by a coupled chromogenic substrate assay. Results; Basal vWF levels for type I diabetics (124±16%, MeantSEM) and type II (178±14%) were increased as compared to controls (94±6%), p<.05 and p<.005, respectively. vWF levels for diabetics with proliferative retinopathy (194±29%) were significantly higher than for diabetics with background retinopathy (106±13%) p<.01. Diabetics with elevated basal levels of vWF (>150%) showed less of an increase in vWF following DDAVP infusion than diabetics with normal basal levels (p<.01). The percent increase in vWF following DDAVP administration inversely correlated with basal vWF levels (type I, r=.51; p<.01 and type II, r=.46; p<.01). The basal vWF level was the significant determinant of DDAVP response, not the presence or absence of diabetic complications. Peak t-PA levels showed no difference in controls or diabetics. In contrast to the vWF response, a normal t-PA response to DDAVP infusion was observed in diabetics. Conclusion: Diabetics with microvascular complications and high circulating levels of vWF demonstrate a blunted vWF response to DDAVP. This supports the existence of a negative feedback mechanism as previously reported for the transfused hemophiliacs.
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Dong, Pingsha, and Jeong K. Hong. "Fatigue of Tubular Joints: Hot Spot Stress Method Revisited." In ASME 2008 27th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/omae2008-57914.
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A series of well-known tubular joints tested in UKSORP II have been re-evaluated using the mesh-insensitive structural stress method as a part of the on-going Battelle Structural Stress JIP efforts. In this report, the structural stress based analysis procedure is first presented for applications in tubular joints varying from simple T joints, double T Joints, YT joints with overlap and K joints with various internal stiffening configurations. The structural stress based SCFs are then compared with those obtained using traditional surface extrapolation based hot spot stress methods. Their abilities in effectively correlating the fatigue data collected from these tubular joints are demonstrated. These tests are also compared with the T curve typically used for fatigue design of tubular joints as well as the structural stress based master S-N curve adopted by ASME Section VIII Div 2. Finally, some of the implications on fracture mechanics based remaining life assessment for tubular joints are discussed in light of the results obtained in this investigation.