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1

Wang, Jie, Adam S. Asch, Nada Hamad, Andrew Weickhardt, Monika Tomaszewska-Kiecana, Monika Dlugosz-Danecka, Halyna Pylypenko, et al. "A Phase 1, Open-Label Study of MGD013, a Bispecific DART® Molecule Binding PD-1 and LAG-3 in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma." Blood 136, Supplement 1 (November 5, 2020): 21–22. http://dx.doi.org/10.1182/blood-2020-139868.

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Background: MGD013 is an investigational, first-in-class, Fc-bearing bispecific tetravalent DART molecule designed to bind PD-1 and LAG-3 and sustain/restore the function of exhausted T cells (1). MGD013 demonstrates in vitro ligand blocking properties and improved T-cell responses beyond that observed with anti-PD-1 and anti-LAG-3 benchmark antibodies alone or in combination. PD-1 targeted therapy with nivolumab in patients (pts) with relapsed or refractory (R/R) diffuse large B cell lymphoma (DLBCL) has yielded modest efficacy (2). LAG-3, highly expressed in DLBCL (3), has emerged as another therapeutic target of interest in this population with continued unmet need. Methods: This study characterizes the safety, tolerability, dose-limiting toxicities, maximum tolerated dose, PK/PD, and antitumor activity of MGD013 in pts with advanced solid and hematologic malignancies. R/R DLBCL pts are being treated at the recommended Phase 2 dose of 600 mg every two weeks in Cohort Expansion. Results: At data-cutoff, 17 DLBCL pts received MGD013 (2.5 median prior lines of therapy, 41.2% with prior CAR-T therapy). Treatment-related adverse events (TRAEs) occurred in 11/17 (64.7%) pts, with no same TRAE occurring in > 1 patient except pyrexia (n=3). One grade ≥ 3 TRAE occurred (pneumonia), and no events of tumor lysis syndrome were observed. Among 11 response-evaluable pts (i.e. received at least one on-treatment scan), 1 complete response (CR) and 3 partial responses (PRs) per the Lugano Classification were observed. Analyses of available pre-treatment tumor biopsy samples corresponding to responding pts demonstrated relatively high levels of LAG-3, PD-1, and PD-L1 by IHC. More comprehensive translational analyses were undertaken for the pt with CR, observed after a single MGD013 infusion in a 28-year-old male in relapse 6 months after CD19-directed CAR T-cell therapy. In contrast to a pre-CAR T biopsy specimen demonstrating no LAG-3 or PD-1 expression, IHC analysis of a lymph node specimen biopsied post-CAR T and prior to MGD013 treatment revealed high levels of both LAG-3 and PD-1 on both infiltrating T-cells and malignant B-cells. Consistent with CD19 CAR T resistance, no CD19 expression was evident. MHC class II and PD-L1 expression were observed, which when bound to LAG-3 and PD-1, respectively, form immune checkpoints that can decrease T cell function. Following MGD013 treatment, serum IFN-γ markedly increased to >140-fold above baseline. No significant changes were observed for IL-6 or IL-2. Expansion of circulating CD3+CD8+ and CD3+CD4-CD8- T-cell subsets and associated cytolytic markers (i.e., perforin, granzyme B) were observed following MGD013 treatment. The patient underwent allogeneic stem cell transplant (allo-SCT) and remains in remission 14 months post-MGD013 and 12 months post-allo-SCT. Further correlative biomarker analyses are underway in the ongoing clinical trial. Conclusion: MGD013, a novel molecule designed to coordinately block PD-1 and LAG-3, has preliminarily demonstrated an acceptable safety profile and encouraging early evidence of anti-tumor activity in R/R DLBCL pts with and without prior treatment with CAR T. Biomarker analyses confirmed expression of both PD-1 and LAG-3 axes in responding pts with evidence of pharmacodynamic responses consistent with the ability of MGD013 to enhance T-cell function. References: 1. Luke JJ, Patel MR, Hamilton E, et al. A phase I, first-in-human, open-label, dose-escalation study of MGD013, a bispecific DART molecule binding PD-1 and LAG-3, in patients with unresectable or metastatic neoplasms. J Clin Oncol 38: 2020 (suppl; abstr 3004). 2. Keane C, Law SC, Gould C, et al. LAG3: a novel immune checkpoint expressed by multiple lymphocyte subsets in diffuse large B-cell lymphoma. Blood Adv. 2020;4(7):1367-1377. doi:10.1182/bloodadvances.2019001390 3. Ansell SM, Minnema MC, Johnson P, et al., Nivolumab for Relapsed/Refractory Diffuse Large B-Cell Lymphoma in Patients Ineligible for or Having Failed Autologous Transplantation: A Single-Arm, Phase II Study. J Clin Oncol, 2019. 37(6): p. 481-489. Disclosures Wang: Verastem Oncology: Membership on an entity's Board of Directors or advisory committees; Curio Science: Honoraria; Putnam LLC: Honoraria. Asch:Astellas Pharma: Research Funding; Cartesian: Research Funding; Forty Seven: Research Funding; Juno: Research Funding; MacroGenics: Research Funding; MEI Pharma: Patents & Royalties: Provisional patent submitted (I), Research Funding. Hamad:Novartis: Honoraria; Abbvie: Honoraria. Weickhardt:Merck: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS: Membership on an entity's Board of Directors or advisory committees, Research Funding; Ipsen: Membership on an entity's Board of Directors or advisory committees; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Ulahannan:Merck Co. Inc: Research Funding; Bayer: Membership on an entity's Board of Directors or advisory committees; G1 Therapeutics, Inc.: Research Funding; ArQule, Inc.: Research Funding; Evelo Biosciences, Inc.: Research Funding; Incyte: Membership on an entity's Board of Directors or advisory committees, Research Funding; Klus Pharma, Inc.: Research Funding; Isofol: Research Funding; GlaxoSmithKline GSK: Research Funding; Mersana Therapeutics: Research Funding; Macrogenics: Research Funding; Celgene Corporation: Research Funding; Boehringer Ingelheim: Research Funding; Array: Membership on an entity's Board of Directors or advisory committees; Ciclomed LLC: Research Funding; AbbVie, Inc.: Research Funding; AstraZeneca: Research Funding; Bristol-Myers Squibb: Research Funding; Syros: Membership on an entity's Board of Directors or advisory committees; Exelxis: Membership on an entity's Board of Directors or advisory committees. Koucheki:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Sun:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Li:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Chen:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Zhang:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Muth:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Kaminker:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Moore:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company. Sumrow:MacroGenics, Inc.: Current Employment, Current equity holder in publicly-traded company.
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2

Baltas, M., J. D. Bastide, L. Cazaux, L. Gorrichon-Guigon, P. Maroni, and P. Tisnes. "Zinc(II) complexes of sulfinamides—II. t-Butyl N-(hydroxyphenyl) and t-butyl N-(o-aminophenyl) sulfinamoyl acetates." Spectrochimica Acta Part A: Molecular Spectroscopy 41, no. 6 (January 1985): 793–96. http://dx.doi.org/10.1016/0584-8539(85)80023-4.

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3

Ha, Kwang. "Crystal structure of (1,4,8,11-tetraazacyclotetradecane-κ4N,N′,N′′,N′′′)palladium(II) tetracyanonickelate(II), C14H24N8NiPd." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 1 (December 18, 2019): 77–78. http://dx.doi.org/10.1515/ncrs-2019-0497.

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4

Doğan, F., M. Ulusoy, Ö. F. Öztürk, İ. Kaya, and B. Salih. "Thermal studies of Co(II), Ni(II) and Cu(II) complexes of N,N′-bis(3,5-Di-t-butylsalicylidene)ethylenediamine." Journal of Thermal Analysis and Calorimetry 96, no. 1 (March 12, 2009): 267–76. http://dx.doi.org/10.1007/s10973-008-8980-8.

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5

Ha, Kwang. "Crystal structure of cyclo[tetra(μ2-cyanido)-tetracyanido-bis(1,4,7,10-tetraazacyclododecane-κ4N,N′,N′′,N′′′)dinickel(II)dipalladium(II)] hexahydrate, C24H52N16Ni2O6Pd2." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 1 (December 18, 2019): 201–2. http://dx.doi.org/10.1515/ncrs-2019-0574.

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AbstractC24H52N16Ni2O6Pd2, monoclinic, P21/c (no. 14), a = 8.6416(3) Å, b = 14.2237(5) Å, c = 15.5573(5) Å, β = 93.8054(12)°, V = 1908.02(11) Å3, Z = 2, Rgt(F) = 0.0312, wRref(F2) = 0.0915, T = 223(2) K.
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6

Maher, P. J. "Commutator and self-commutator approximants II." Filomat 24, no. 4 (2010): 1–7. http://dx.doi.org/10.2298/fil1004001m.

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We minimize the quantities (i) ||T -(AX-X A) ||, (ii) ||T -(X*X-XX*)|| and (iii) ||T -(AX - X B)|| where T is isometric and where in (i) A is paranormal and commutes with T , in (ii) X*(or X ) is paranormal and commutes with T , and in (iii) A and B are paranormal and AT = T B and T A = BT. The upshot is that these quantities are minimized when 0 = AX - XA = X*X - XX*= AX - XB. To prove these results we obtain the power norm equality for paranormal operators: if A is paranormal then ||An|| = ||A||n if n?N.
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7

Killinger, William A., Thomas W. Rice, David J. Adelstein, Sharon V. Medendorp, Gregory Zuccaro, Thomas J. Kirby, and John R. Goldblum. "Stage II esophageal carcinoma: The significance of T and N." Journal of Thoracic and Cardiovascular Surgery 111, no. 5 (May 1996): 935–40. http://dx.doi.org/10.1016/s0022-5223(96)70367-7.

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8

Kim, Kang-Woo, and Jinhee Kim. "Crystal structure of bis(N,N,N-triethylammonium) bis(tetraselenido-κ2Se1,Se4)palladate(II), C12H32N2PdSe8." Zeitschrift für Kristallographie - New Crystal Structures 230, no. 3 (September 1, 2015): 269–70. http://dx.doi.org/10.1515/ncrs-2014-9015.

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9

Baltas, M., J. D. Bastide, A. de Blic, L. Cazaux, L. Gorrichon-Guigon, P. Maroni, M. Perry, and P. Tisnes. "Zinc(II) complexes of sulfinamides—I. N-Phenyl 2-propane sulfinamide, t-butyl N-phenyl and t-butyl N-cyclohexyl sulfinamoyl acetates." Spectrochimica Acta Part A: Molecular Spectroscopy 41, no. 6 (January 1985): 789–92. http://dx.doi.org/10.1016/0584-8539(85)80022-2.

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Mao, Pan-Dong, Xiao-Lei Zhao, Qing-Wen Yang, Miao Yang, and Yuan Wang. "Crystal structure of [N,N-bis((pyrrol-2-yl)ethylidene)butane-1,4-diamine-κ4N,N′,N′′,N′′′]-nickel(II), C16H20N4Ni." Zeitschrift für Kristallographie - New Crystal Structures 233, no. 1 (January 26, 2018): 101–2. http://dx.doi.org/10.1515/ncrs-2017-0190.

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Ma, J. Y., T. X. Wu, X. G. She, and X. F. Pan. "Crystal structure of dichloro((N-(N′,N′-dimethylammonio)ethyl)- 2,4-dichlorosalicylaldiminato-N,O)copper(II), Cu(C11H14Cl2N2O)Cl2." Zeitschrift für Kristallographie - New Crystal Structures 221, no. 1 (March 2006): 53–54. http://dx.doi.org/10.1524/ncrs.2006.221.1.53.

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12

Kim, Kang-Woo, and Di Wang. "Crystal structure of bis(N,N,N-ethyldimethylethanaminium) bis(heptaselenido-κ2Se1,Se7)palladate(II), C12H32N2PdSe14." Zeitschrift für Kristallographie - New Crystal Structures 232, no. 6 (November 27, 2017): 965–67. http://dx.doi.org/10.1515/ncrs-2017-0101.

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Blom, Burgert, Günter Klatt, Daniel Gallego, Gengwen Tan, and Matthias Driess. "Unprecedented silicon(ii)→calcium complexes with N-heterocyclic silylenes." Dalton Transactions 44, no. 2 (2015): 639–44. http://dx.doi.org/10.1039/c4dt03148b.

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The first N-heterocyclic silylene (NHSi) complexes of any s-block element to date are reported for calcium: [(η5-C5Me5)2Ca←:Si(O-C6H4-2-tBu){(NtBu)2CPh}] and [(η5-C5Me5)2Ca←:Si(NtBuCH)2]. The synthesis, structure, bonding analysis by DFT methods and the reactivity towards oxygen containing substrates is discussed.
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14

Ha, Kwang. "Crystal structure of catena-poly[(1,4,8,11-tetraazacyclotetradecane-κ 4 N,N′,N″,N′′′)-bis(μ 2-thiocyanato-κ2 N:S)-bis(thiocyanato-κS)-nickel(II)palladium(II)], C14H24N8NiPdS4." Zeitschrift für Kristallographie - New Crystal Structures 236, no. 3 (February 15, 2021): 631–33. http://dx.doi.org/10.1515/ncrs-2021-0025.

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Abstract C14H24N8NiPdS4, triclinic, P 1 ‾ $P‾{1}$ (no. 2), a = 12.0330(8) Å, b = 12.0959(8) Å, c = 15.9551(12) Å, α = 85.768(3)°, β = 71.917(3)°, γ = 87.899(3)°, V = 2201.3(3) Å3, Z = 4, R gt (F) = 0.0379, wR ref (F 2) = 0.0973, T = 223 K.
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15

Cheng, M. Q., L. F. Ma, and L. Y. Wang. "Crystal structure of (phenanthroline-N,N′)-N-carbamoylmethyl-iminodiacetato- copper(II) dihydrate, [Cu(C6H8N2)(C12H8N2)] · 2H2O." Zeitschrift für Kristallographie - New Crystal Structures 221, no. 3 (September 2006): 369–71. http://dx.doi.org/10.1524/ncrs.2006.0114.

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Arslan, H., D. Vanderveer, F. Emen, and N. Külcü. "Crystal structure of cis-bis(N,N-dimethyl-N′-4-chlorobenzoylthioureato) palladium(II), Pd(C10H10ClN2OS)2." Zeitschrift für Kristallographie - New Crystal Structures 218, no. 4 (December 2003): 479–80. http://dx.doi.org/10.1524/ncrs.2003.218.4.479.

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17

Tan, Yee Seng, and Edward R. T. Tiekink. "Crystal structure of bis(μ-N-i-propyl-N-n-propyldithiocarbamato-κ2S:S′) bis(N-i-propyl-N-n-propyldithiocarbamato-κ2S,S′)dizinc(II), C28H56N4S8Zn2." Zeitschrift für Kristallographie - New Crystal Structures 233, no. 3 (May 24, 2018): 477–79. http://dx.doi.org/10.1515/ncrs-2017-0366.

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18

Wang, Xinfang. "Crystal structure of tris(1,10-phenanthroline-N,N')manganese(II)dichloro octahydrate, C36H40Cl2MnN6O8." Zeitschrift für Kristallographie - New Crystal Structures 228, no. 1 (March 1, 2013): 5–6. http://dx.doi.org/10.1524/ncrs.2013.0003.

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Xu, Zhi-Hong, Ye Shen, and Wei-Na Wu. "Crystal structure of dinitrato-(N′-((quinolin-8-yl)methylene)isonicotinohydrazide κ3-N,N′,O)copper(II), C16H12N6O7Cu." Zeitschrift für Kristallographie - New Crystal Structures 233, no. 2 (March 28, 2018): 309–10. http://dx.doi.org/10.1515/ncrs-2017-0307.

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20

Wang, Di, Hoseop Yun, and Kang-Woo Kim. "Crystal structure of bis(N,N,N-trimethylethanaminium) poly[bis(μ2-heptaselenido-κ2Se1,Se7)palladate(II)], C10H28N2PdSe14." Zeitschrift für Kristallographie - New Crystal Structures 232, no. 6 (November 27, 2017): 995–97. http://dx.doi.org/10.1515/ncrs-2017-0126.

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21

Kiwada, Tatsuto, Hiromu Katakasu, and Akira Odani. "Crystal structure of (N-benzylpropane-1,3-diamine-κ2N, N′)(2,2′-bipyridine-κ2N,N′)platinum(II) chloride, C20H24Cl2N4Pt." Zeitschrift für Kristallographie - New Crystal Structures 234, no. 3 (March 26, 2019): 539–41. http://dx.doi.org/10.1515/ncrs-2018-0543.

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22

Ha, Kwang. "Crystal structure of poly[tetra(μ 2-cyanido-κ2 N:O)-bis(N,N-dimethylformamide-κO)-manganese(II)-platinum(II)], C10H14MnN6O2Pt." Zeitschrift für Kristallographie - New Crystal Structures 236, no. 3 (February 11, 2021): 613–14. http://dx.doi.org/10.1515/ncrs-2021-0028.

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Abstract C10H14MnN6O2Pt, monoclinic, C2/m (no. 12), a = 15.8030(7) Å, b = 7.6794(3) Å, c = 7.0970(3) Å, β = 110.8462(17)°, V = 804.89(6) Å3, Z = 2, R gt (F) = 0.0108, wR ref (F 2) = 0.0266, T = 223 K.
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23

Tan, Yee Seng, and Edward R. T. Tiekink. "Crystal structure of bis(μ-N-i-propyl-N-n-propyldithiocarbamato-κ3S,S′:S)bis(N-i-propyl-N-n-propyldithiocarbamato-κ2S,S′)dicadmium(II), C28H56Cd2N4S8." Zeitschrift für Kristallographie - New Crystal Structures 233, no. 3 (May 24, 2018): 481–83. http://dx.doi.org/10.1515/ncrs-2017-0367.

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24

Patterson, Richard, and Ekrem Savaș. "On double sequences of continuous functions having continuous P-limits II." Filomat 27, no. 5 (2013): 931–35. http://dx.doi.org/10.2298/fil1305931p.

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The goal of this paper is to relax the conditions of the following theorem: Let A be a compact closed set; let the double sequence of function s1,1 (x), s1,2 (x) s1,3 (x) . . . s2,1 (x), s2,2 (x) s2,3 (x) . . . s3,1 (x), s3,2 (x) s3,3 (x) . . . have the following properties: 1. for each (m, n) sm,n (x) is continuous in A; 2. for each x in A we have P - limm,n sm,n (x) = s(x); 3. s(x) is continuous in A; 4. there exists M such that for all (m, n) and all x in A |sm,n (x)| ? M. Then there exists a T -transformation such that P lim ?m,n (x) = s(x) uniformly in A m,n and to that end we obtain the following. In order that the transformation be such that P - lim s?s0 (S);t?t0 (T) ?(s; t; x) = 0 uniformly with respect x for every double sequence of continuous functions (sm,n (x)) define over A such that sm,n (x) is bounded over A and for all (m, n) and P - limm,n sm,n (x) = 0 over A it is necessary and sufficient that P - lim ?,? ? |ak,l (s, t)| = 0. s?s0 (S);t?t0 (T) k,l=1,1 .
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25

Lee, Sungchul. "The central limit theorem for Euclidean minimal spanning trees II." Advances in Applied Probability 31, no. 04 (December 1999): 969–84. http://dx.doi.org/10.1017/s0001867800009551.

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Let X i : i ≥ 1 be i.i.d. points in ℝ d , d ≥ 2, and let T n be a minimal spanning tree on X 1,…,X n . Let L(X 1,…,X n ) be the length of T n and for each strictly positive integer α let N(X 1,…,X n ;α) be the number of vertices of degree α in T n . If the common distribution satisfies certain regularity conditions, then we prove central limit theorems for L(X 1,…,X n ) and N(X 1,…,X n ;α). We also study the rate of convergence for EL(X 1,…,X n ).
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Yamaguchi, Jun-ichi, Yuji Shusa, and Takayuki Suyama. "A convenient transformation of N-substituted ureas into N-(t-butoxycarbonyl)amines using a copper(II) salt-lithium t-butoxide system." Tetrahedron Letters 40, no. 47 (November 1999): 8251–54. http://dx.doi.org/10.1016/s0040-4039(99)01751-7.

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BOYLAN, MATTHEW, and KEN ONO. "PARITY OF THE PARTITION FUNCTION IN ARITHMETIC PROGRESSIONS, II." Bulletin of the London Mathematical Society 33, no. 5 (September 2001): 558–64. http://dx.doi.org/10.1112/s0024609301008438.

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Let p(n) denote the ordinary partition function. Subbarao conjectured that in every arithmetic progression r (mod t) there are infinitely many integers N ≡ r (mod t) for which p(N) is even, and infinitely many integers M ≡ r (mod t) for which p(M) is odd. We prove the conjecture for every arithmetic progression whose modulus is a power of 2.
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Mphure, Lebohang Theodora, Hendrik G. Visser, Andreas Roodt, and Alice Brink. "Crystal structure of dichloro-N,N-bis(pyridine-2-ylmethyl)cyclohexamino copper(II), C18H23Cl2CuN3." Zeitschrift für Kristallographie - New Crystal Structures 230, no. 2 (June 1, 2015): 156–58. http://dx.doi.org/10.1515/ncrs-2014-9042.

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Zheng, Y. Q., and Z. P. Kong. "Crystal structure of monoaqua(1,10-phenanthroline-N,N′)- succinatocobalt(II), Co(H2O)(C12H8N2)(C4H4O4)." Zeitschrift für Kristallographie - New Crystal Structures 218, no. 2 (June 2003): 223–24. http://dx.doi.org/10.1524/ncrs.2003.218.2.223.

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Abstract C16H14CoN2O5, triclinic, P1 (No. 2), a = 7.499(1) Å, b = 10.270(1) Å, c = 10.490(1) Å, α = 97.65(1)°, β = 106.80(1)°, γ = 100.57(1)°, V = 745.3 Å3, Z = 2, Rgt(F) = 0.058, wRref(F2) = 0.151, T = 293 K.
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30

Wang, Li. "Automorphism Groups of the Imprimitive Complex Reflection Groups II." Algebra Colloquium 18, no. 02 (June 2011): 315–26. http://dx.doi.org/10.1142/s1005386711000216.

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We prove that the automorphism group Aut (m,p,n) of an imprimitive complex reflection group G(m,p,n) is the product of a normal subgroup T(m,p,n) by a subgroup R(m,p,n), where R(m,p,n) is the group of automorphisms that preserve reflections and T(m,p,n) consists of automorphisms that map every element of G(m,p,n) to a scalar multiple of itself.
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Jing, Chen, Zhang Lingcong, Chen Jingwen, and Zhang Haodong. "Crystal structure of [tris(2-benzimidazolylmethyl)amine-κ4N,N′,N′′,N′′′]-[(pyridine-2,6-dicarboxylato-κ2O,N)]cadmium(II)–methanol (1:3) C34H36CdN8O7." Zeitschrift für Kristallographie - New Crystal Structures 233, no. 6 (November 27, 2018): 1047–49. http://dx.doi.org/10.1515/ncrs-2018-0162.

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Li, Li. "Crystal structure of bis[3-methoxy-N-(1-(pyrazin-2-yl)ethylidene)benzohydrazonato-κ3O,N,N′]nickel(II), C28H26N8O4Ni." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 5 (August 26, 2020): 1063–64. http://dx.doi.org/10.1515/ncrs-2020-0170.

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Deng, Xiao-Wei, and Wei-Na Wu. "Crystal structure of bis(3-methoxy-N-(1-(pyridin-2-yl)ethylidene)benzohydrazonato κ3O,N,N′)zinc(II), C30H28N6O4Zn." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 2 (February 25, 2020): 421–22. http://dx.doi.org/10.1515/ncrs-2019-0726.

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34

Yang, Xue-Mei, Tao Zhu, and Long Lin. "Crystal structure of bis(3-methyl-N-(1-(pyrazin-2-yl)ethylidene)benzohydrazonato-κ3O,N,N′)nickel(II), C28H26N8O2Ni." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 3 (April 28, 2020): 585–86. http://dx.doi.org/10.1515/ncrs-2019-0833.

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35

Ok, Seung Ryong, and Dieter W. Gruenwedel. "Differential Effect of Hg(II) on [d(A)n · d(T)n] and [d(A-T)n · d(A-T)n] Sequences: Circular Dichroism (CD) Measurements and Endonuclease Digestion Studies Using Poly[d(A) · d(T)] and Poly[d(A-T) · d(A-T)] as Substrates." Zeitschrift für Naturforschung C 48, no. 5-6 (June 1, 1993): 488–94. http://dx.doi.org/10.1515/znc-1993-5-614.

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Abstract The long-wavelength positive CD bands of poly[d(A) · d(T)] and poly[d(A-T) · d(A-T)] become inverted upon the addition of Hg(ClO4)2. Poly[d(A) · d(T)] requires higher levels of mercury to undergo inversion than poly[d(A-T) · d(A-T)]. Mercurated poly[d(A) d(T)] is digested more rapidly than the control by DNase I or staphylococcal nuclease at low levels of Hg(ClO4)2. Let r = [Hg(ClO4)2]added/[DNA-P]. A 4- to 5-fold rate increase occurs with DNase I at r = 0.25; a 2-fold increase with staphylococcal nuclease at r = 0.2. By contrast, digestion of poly[d(A-T )· d(A-T)] decreases immediately with increasing r. The noted rate increases appear to be due to a modification of poly[d(A)-d(T)] helix structure prior to the chiroptical conversion. The modification is interpreted as a widening of the minor groove, permitting, thus, a better binding of DNase I to its substrate. The overall changes in CD as well as enzymatic digestion rates are taken to signal mercury-induced alterations in helix screwness from rightto- left. They are totally reversible subsequent to the removal of mercury.
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36

Rivada-Wheelaghan, Orestes, Bruno Donnadieu, Celia Maya, and Salvador Conejero. "T-Shaped Platinum(II) Complexes Stabilised by Bulky N-Heterocyclic Carbene Ligands." Chemistry - A European Journal 16, no. 34 (July 23, 2010): 10323–26. http://dx.doi.org/10.1002/chem.201000955.

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37

Balibrea, F., and A. Linero. "Periodic structure of $ \sigma $-permutation maps II. The case $ \mathbb{T}^{n} $." aequationes mathematicae 64, no. 1-2 (August 2002): 34–52. http://dx.doi.org/10.1007/s00010-002-8029-1.

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38

Ishikawa, Yuki, Keiko Miyamoto, and Ernst Horn. "Crystal structure of trans-diacetonitrile diaqua(N,N,N',N'-tetramethylethylenediamine) nickel(II) diiodide, [Ni(tmen)(CH3CN)2(H2O)2]2+·2I–, C10H26I2N4NiO2." Zeitschrift für Kristallographie - New Crystal Structures 228, no. 2 (June 1, 2013): 167–68. http://dx.doi.org/10.1524/ncrs.2013.0049.

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39

He, H. Y., Y. L. Zhou, and L. G. Zhu. "Crystal structure of triaqua(1,10-phenanthroline-N,N′)sulfatonickel(II), Ni(H2O)3(C12H8N2)SO4." Zeitschrift für Kristallographie - New Crystal Structures 218, no. 4 (December 2003): 563–64. http://dx.doi.org/10.1524/ncrs.2003.218.4.563.

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40

Gao, Xiao-Li, Rong-Li Geng, and Pai Chen. "Crystal structure of bis-[N-(1-pyrazin-2-yl-ethylidene)-cyanoacetic acid-hydrazonato-κ3O,N,N′)]-zinc(II), C18H16N10O2Zn." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 2 (February 25, 2020): 503–4. http://dx.doi.org/10.1515/ncrs-2019-0813.

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AbstractC18H16N10O2Zn, triclinic, P1̄ (no. 2), a = 10.218(7) Å, b = 10.490(7) Å, c = 11.101(8) Å, α = 79.590(11)°, β = 65.913(12)°, γ = 66.785(10)°, V = 998.0(12) Å3, Z = 2, Rgt(F) = 0.0516, wRref(F2) = 0.1323, T = 293(2) K.
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41

Dani, S. G. "On orbits of unipotent flows on homogeneous spaces, II." Ergodic Theory and Dynamical Systems 6, no. 2 (June 1986): 167–82. http://dx.doi.org/10.1017/s0143385700003382.

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AbstractWe show that if (ut) is a one-parameter subgroup of SL (n, ℝ) consisting of unipotent matrices, then for any ε > 0 there exists a compact subset K of SL(n, ℝ)/SL(n, ℤ) such that the following holds: for any g ∈ SL(n, ℝ) either m({t ∈ [0, T] | utg SL (n, ℤ) ∈ K}) > (1 – ε)T for all large T (m being the Lebesgue measure) or there exists a non-trivial (g−1utg)-invariant subspace defined by rational equations.Similar results are deduced for orbits of unipotent flows on other homogeneous spaces. We also conclude that if G is a connected semisimple Lie group and Γ is a lattice in G then there exists a compact subset D of G such that for any closed connected unipotent subgroup U, which is not contained in any proper closed subgroup of G, we have G = DΓ U. The decomposition is applied to get results on Diophantine approximation.
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42

Ha, Kwang. "Crystal structure of (1,4,8,11-tetraazacyclotetradecane)palladium(II) tetracyanopalladate(II), C14H24N8Pd2." Zeitschrift für Kristallographie - New Crystal Structures 232, no. 1 (January 1, 2017): 139–40. http://dx.doi.org/10.1515/ncrs-2016-0193.

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43

Ou, Guang-Chuan, Qiang Zhou, and Qiong Wang. "Crystal structure of (4-aminobenzoato-κ2O,O′)-[5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-κ4N,N′,N′′,N′′′]nickel(II) perchlorate monohydrate, C23H44ClN5NiO7." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 5 (August 26, 2020): 1095–97. http://dx.doi.org/10.1515/ncrs-2020-0184.

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44

Ma, Ning, and Ye Wang. "Crystal structure of tetraaqua dinitrato-κ2O,O'-4,4',6,6'-tetramethyl-2,2'- bipyrimidine-κ4N,N':N'',N''' dinickel(II) dinitrate, C6H11N4NiO8." Zeitschrift für Kristallographie - New Crystal Structures 229, no. 2 (June 1, 2014): 109–10. http://dx.doi.org/10.1515/ncrs-2014-0057.

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45

Jin, Q. H., L. Yang, X. L. Xin, H. W. Gao, J. C. Dong, and P. Z. Li. "Crystal structure of aqua(phenanthroline-N,N′)(glycinato-N,O)copper(II) bromide hydrate, [Cu(NH2CH2COO)(C12H8N2)(H2O)]Br · H2O." Zeitschrift für Kristallographie - New Crystal Structures 221, no. 3 (September 2006): 383–84. http://dx.doi.org/10.1524/ncrs.2006.0120.

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46

Antolini, Floria, Peter B. Hitchcock, Alexei V. Khvostov, and Michael F. Lappert. "Synthesis and characterization of N-silylated, C1-symmetric benzamidinates of lithium, sodium, and tin(II)." Canadian Journal of Chemistry 84, no. 2 (February 1, 2006): 269–76. http://dx.doi.org/10.1139/v05-250.

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The synthesis and characterization of complexes obtained from the reactions between Li[N-t-Bu(SiMe3)] (A) or the sodium analogue Na[N-t-Bu(SiMe3)] (B) and the cyanoarene RCN (R = Ph or 4-MeOC6H4) are discussed. These are the THF adduct [Li{µ-cis-N(t-Bu)C(Ph)N(SiMe3)}(THF)]2 (1), the TMEDA adduct Li[N(t-Bu)C(Ph)N(SiMe3)](TMEDA) (2), the neutral ligand-free lithium benzamidinate Li[N(t-Bu)C(C6H4OMe-4)N(SiMe3)] (3), and the THF adduct Li[N(t-Bu)C(C6H4OMe-4)N(SiMe3)](THF) (3a). The preparation and structure of the crystalline compound [Na{µ-cis-N(t-Bu)C(Ph)N(SiMe3)}(OEt2)]2 (4) is described. From the lithium benzamidinate 1 and Sn(II) chloride the tin(II) complex [Sn{N(t-Bu)C(Ph)N(SiMe3)}2] (5) was obtained. The molecular structures of the crystalline compounds 1, 4, and 5 were established by X-ray diffraction. In 1 and 4 the benzamidinato ligand is both chelating and bridging, with the Me3Si-substituted nitrogen atom as the bridging site. The central planar (MN)2 four-membered ring is a rhombus in 1, with almost equal Li—N bond lengths, whereas in 4 the bonds to Na(1) are significantly longer than those to Na(2). In 5, the ligand is N,N′-chelating. Key words: alkali metals, tin(II), benzamidinates, NMR spectra, X-ray structures.
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47

Yun, Zhao, Xu Lu, and Zhang Li-Fang. "Crystal structure of (tris(2-pyridylmethyl)amine-κ4N,N′,N′′,N′′′′)-chloranilato-κO,O′-zinc(II) – methanol (1/1), C25H22Cl2N4O5Zn." Zeitschrift für Kristallographie - New Crystal Structures 232, no. 2 (March 1, 2017): 275–77. http://dx.doi.org/10.1515/ncrs-2016-0237.

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48

Guse, A. H., E. Roth, and F. Emmrich. "Intracellular Ca2+ pools in Jurkat T-lymphocytes." Biochemical Journal 291, no. 2 (April 15, 1993): 447–51. http://dx.doi.org/10.1042/bj2910447.

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Jurkat T-lymphocytes comprise at least four intracellular Ca2+ pools. Pool I was agonist-sensitive and contained 23 +/- 8% (n = 18) of the total Ca(2+)-storage capacity, as shown in intact cells in the presence of EGTA. The time courses of the agonist-induced formation of Ins(1,4,5)P3 and of the Ca2+ release from pool I were nearly superimposable, indicating that the agonist-sensitive pool I is emptied by Ins(1,4,5)P3. Likewise, in permeabilized cells, the size of the Ins(1,4,5)P3-sensitive Ca2+ pool I was 27 +/- 11% (n = 14). Pool II contained 26 +/- 5% (n = 9) of intracellularly stored Ca2+ and was liberated by thapsigargin, an inhibitor of the endoplasmic-reticulum (ER) Ca(2+)-ATPase. Addition of thapsigargin before addition of agonist abolished the agonist-induced Ca2+ release in both intact and permeabilized cells, indicating that pool I is a subcompartment of the ER Ca2+ pool. The content of this ER Ca2+ pool (pools I and II) amounted to 51 +/- 15% (n = 9) in intact cells and 49 +/- 16% (n = 16) in permeabilized cells. Caffeine released Ca2+ even when the ER pool (pools I and II) was emptied by previous addition of thapsigargin, indicating the presence of a third pool independent of pools I and II. Pool III contained 23 +/- 6% (n = 8) in intact cells, but 41 +/- 8% (n = 5) in permeabilized cells. The remaining intracellularly stored Ca2+ was released by addition of the Ca2+ ionophore ionomycin. This fourth pool contained 27 +/- 8% (n = 9) in intact cells, but less than 10% in permeabilized cells. The size of pool III was increased when pools I and II were emptied before addition of caffeine, whereas the size of pool IV was decreased under such conditions. In conclusion, this first comprehensive description of intracellular Ca2+ pools in Jurkat T-lymphocytes demonstrates the presence of four different Ca2+ pools, provides estimates of their sizes and describes relationships between each other. Release of Ca2+ from pool I [Ins(1,4,5)P3-sensitive] has previously been shown to play a major role in T-cell activation, whereas the physiological role of pools II-IV remains to be established.
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49

Li, Ji, and Ming-Zhi Miao. "The crystal structure of aqua{N,N,N′,N′-tetrakis[(1H-benzimidazol-κN3) methyl]cyclohexane-1,2-diamine}lead(II) diacetate–methanol (1/2), C44H54N10O7Pb." Zeitschrift für Kristallographie - New Crystal Structures 235, no. 6 (October 27, 2020): 1417–20. http://dx.doi.org/10.1515/ncrs-2020-0343.

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AbstractPbC44H54N10O7, triclinic, P1̄ (no. 2), a = 12.096(2) Å, b = 12.916(2) Å, c = 16.5904(7) Å, α = 101.163(2)°, β = 110.634(2)°, γ = 100.698(2)°, V = 2287.0(4) Å3, Z = 2, Rgt(F) = 0.0604, wRref(F2) = 0.1409, T = 298(2) K.
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50

Shirvan, Sadif A., Moayad Hossaini Sadr, and Karim Zare. "Crystal structure of 2,2'-biqinoline-κ2N,N')dichloromercury(II), C18H12Cl2HgN2." Zeitschrift für Kristallographie - New Crystal Structures 230, no. 3 (September 1, 2015): 247–48. http://dx.doi.org/10.1515/ncrs-2015-0013.

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