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Dissertations / Theses on the topic 'N-terminal domains'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Chavda, Alap Pravin. "Analysis of N-terminal domains of inositol 1,4,5-trisphosphate receptors." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648299.

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2

Zhu, Shujia. "Allosteric signaling in NMDA receptors via the N-terminal domains." Paris 6, 2013. http://www.theses.fr/2013PA066432.

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Les récepteurs au N-méthyl-D-aspartate (RNMDAs) constituent dans le cerveau une classe majeure de récepteurs activés par le neurotransmetteur excitateur glutamate. Ils forment des canaux ioniques perméables au calcium, au rôle essentiel dans la plasticité synaptique. Les RNMDAs s’assemblent en hétérotétramères, usuellement composés des sous-unités GluN1 et GluN2 (A-D). Des travaux ont révélé le rôle essentiel joué par le domaine N-terminal (NTD) des sous-unités GluN2, dans les fonctions spécifiques des sous-unités des RNMDAs. En revanche, on en sait peu concernant la contribution de GluN1, pou

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3

Nowak, Scott J. "Covalent modifications of histone N-terminal domains during transcription in Drosophila melanogaster." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/308073.

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4

Winzen, Uwe. "Functional analysis of the N-terminal domains of agrin by recombinant eucaryotic expression." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968092020.

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5

Sanchez, Perez Maria Concepcion. "Study of the N-terminal domains of MDM2 and MDM4, and their potential for targeting by small-molecule drugs." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/8763.

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The MDM2 and MDM4 oncoproteins are both involved in regulating the tumour suppressor, p53. While the MDM2–p53 interface is structurally and biophysically well characterised, the MDM4-p53 interaction has only recently attracted researchers’ attentions. The goal of this project was to establish structural and chemical ground rules for the disruption of the interactions between the N-terminal domains of MDM2/4 and p53, which is an attractive anticancer strategy. In the current work, successful recombinant production and purification protocols for both the N-terminal domains of MDM2 (i.e. MDM2-N,

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6

King, Katie. "The Roles and Interactions of the N-terminal Domains of Cardiac Myosin Binding Protein-C." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490093.

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Myosin Binding Protein-C (MyBP-C) is a multi-domain protein located on the thick filaments of striated muscle. Mutations in the gene encoding the cardiac isoform of the protein, cMyBP-C, are known to cause hypertrophic cardiomyopathy (HCM). cMyBP-C is composed of 11 globular domains, eight of which have homology to Igl, the other three to fibronectin III. The N-terminal region of the protein has been assigned a role in the regulation of muscle contraction through its interaction with the Subfragment-2 (S2) portion of myosin.

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7

Liu, Sheng. "NMR studies of RNA binding domains of human lysyl aminoacyl tRNA synthetase." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353343207.

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8

Learmont, Jessica. "Prion-like properties of the N-terminal domains of the rat and human FoxG1 transcription factors." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/4285.

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Word processed copy.<br>Includes bibliographical references (leaves 82-90).<br>The purpose of this study was to investigate the possible prion-like properties of the N-terminal domains of the winged-helix transcription factor FoxG1.

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9

Khan, Samir Ali. "Structure-function relationships between N-terminal domains of inositol 1, 4, 5-trisphosphate receptors and ryanodine receptors." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609991.

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10

Moriarty, Tara J. "Regulation of telomerase-specific catalytic functions by nucleic acid interactions and human telomerase reverse transcriptase N-terminal domains." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85628.

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Telomerase is an unusual reverse transcriptase (RT) that catalyzes the de novo addition of telomeric DNA repeats to telomeres. Telomerase activity counteracts the progressive loss of telomeric DNA over successive rounds of DNA replication, and is important for the immortality of most eukaryotic cells. Telomerase is distinct from other RTs in that its catalytic subunit (TERT: telomerase reverse transcriptase) stably associates with a telomerase RNA (TR) component that contains a short template used to direct synthesis of telomeric repeats. Telomerase also exhibits a unique, repeat additi

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11

Miller, Philip Saxon. "The role of the N-terminal domains of the CGRP receptor in binding peptide agonists and non-peptide antagonists." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534435.

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12

Mitsche, Matthew Alvin. "Interfacial properties of the n-terminal lipid-binding domains of apolipoprotein B and their role in triacylglyceride-rich lipoprotein assembly." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12527.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>ApolipoproteinB (ApoB) is the principal protein component of triacylglyceride (TAG)-rich lipoproteins that are responsible for distribution of hydrophobic lipids to peripheral tissues and are the precursors to

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13

Nagar, Bhushan. "X-ray crystallographic analysis of 1) the two N-terminal domains of epithelial cadherin and 2) C3d, a fragment of the complement protein C3." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63590.pdf.

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14

Glitsos, Gabriel [Verfasser], Ralf [Akademischer Betreuer] Kaldenhoff, and Heribert [Akademischer Betreuer] Warzecha. "N- and C-terminal domains in tobacco aquaporins - Analysis of protein-mediated water permeability in vitro and in silico / Gabriel Glitsos ; Ralf Kaldenhoff, Heribert Warzecha." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2017. http://d-nb.info/1129874680/34.

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15

Dai, Huaien. "Structural and functional studies of interactions between [beta]-1,3-glucan and the N-terminal domains of [beta]-1,3-glucan recognition proteins involved in insect innate immunity." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/15286.

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Doctor of Philosophy<br>Department of Biochemistry<br>Ramaswamy Krishnamoorthi<br>Insect [beta]-1,3-glucan recognition protein ([beta]GRP), a soluble receptor in the hemolymph, binds to the surfaces of bacteria and fungi and activates serine protease cascades that promote destruction of pathogens by means of melanization or expression of antimicrobial peptides. Delineation of mechanistic details of these processes may help develop strategies to control insect-borne diseases and economic losses. Multi-dimensional nuclear magnetic resonance (NMR) techniques were employed to solve the solution s

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16

Gardiner, Laurence. "Characterisation of the N-terminal domain topoisomerase IIα". Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/29623.

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17

Geissinger, Jared Scott. "Structure-Function Analysis of the EsaR N-terminal Domain." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/46190.

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The LuxR protein family is a class of quorum-sensing regulated bacterial transcription factors that alter gene expression as a function of ligand detection. This coincides with a high population density and/or a low rate of signal ligand diffusion. The majority of LuxR proteins are activated only in the presence of the signal ligand, an acyl-homoserine lactone (AHL). EsaR, from the corn pathogen Pantoea stewartii, represents a subset of LuxR homologues that are active in the absence of AHL and deactivated by its presence. The mechanism by which EsaR responds to AHL in a manner opposite to tha

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18

Luczynski, Maciej Tomasz. "Structure-guided functional analysis of the pRb N-terminal domain." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531336.

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19

Evans, S. P. "Characterisation of the N-terminal domain of eukaryotic ribonuclease HI." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598870.

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In addition to the conserved and well-defined RNase H domain, eukaryotic RNases HI possess either one or two copies of a small N-terminal domain. The solution structure of one of the N-terminal domains from <I>S. cerevisiae</I> RNase HI, determined using NMR spectroscopy, is presented. The 46 residue motif comprises a three-stranded antiparallel β-sheet and two short α-helices which pack onto opposite faces of the β-sheet. Conserved residues involved in packing the α-helices onto the β-sheet form the hydrophobic core of the domain. The structure shows that the RNase HI N-terminal domain is not

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20

Salek, Reza M. "NMR studies of the heat shock protein 90 N-terminal domain." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446807/.

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The Hsp90 based chaperone is a ubiquitous protein-folding system in the cytoplasm of eukaryotes. Several signal transduction systems and cell cycling pathways utilise an interaction with Hsp90 as an essential component. The Hsp90 chaperone is an ATP dependent chaperone, which is active as a dimer. The N- terminal domain of Hsp90 itself has very weak ATPase activity and plays an essential role in the mechanism of dimerisation. This study attempts to elucidate the nucleotide binding effects on the Hsp90 N-terminal domain by NMR. Accomplishing backbone assignments of the apo- and AMP-PNP bound fo

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21

Agah, Sayeh. "Parvalbumin stability and calcium affinity : the impact of the n-terminal domain /." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?3164486.

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22

Knoblich, Konstantin. "Functional characterisation of the N-terminal domain of polyomavirus large T antigen." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/600/.

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Although scientists have extensively researched the relationship between viral oncoproteins and cellular tumour suppressor proteins in recent years, the molecular interactions between these proteins is still poorly understood. It is the goal of this thesis to establish the key elements of specific interactions, in particular to characterise the interaction between the N-terminal part of the viral murine polyoma oncoprotein large T antigen (PyLTNT), and the cellular human regulator protein retinoblastoma (pRb). The homologous SV40 large T antigen protein has been studied thoroughly in recent de

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23

Baloglu, Cetin. "N terminal and DNA binding domain interactions of tumour suppressor protein p53." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608567.

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24

Swan, Katherine. "The role of N-terminal domain in regulation of mineralocorticoid receptor function." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26538.

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The N-terminal domain of the mineralocorticoid receptor (MR) exhibits no significant sequence homology to the highly related glucocorticoid receptor. I report here that amino acids 450--602 of the N-terminus play a role in three aspects of MR degradation: (1) degradation in the absence of aldosterone mediated by the 26S proteasome, (2) degradation in the presence of aldosterone mediated by the 26S proteasome, and (3) degradation in the presence of aldosterone not mediated by the 26S proteasome. Concurrently I determined that aldosterone treatment following transient expression of MR in Cos-7 c

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25

Aponte, Emilie. "Régulation de la signalisation de Src par son domaine N-terminal intrinsèquement désordonné." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT095.

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La tyrosine kinase cytoplasmique Src est un régulateur essentiel de la croissance et de l’adhésion cellulaires induites par de nombreux stimuli extracellulaires, dont les facteurs de croissance et certains composants de la matrice extracellulaire. La dérégulation de son activité catalytique lui confère des propriétés oncogéniques importantes conduisant à la formation de tumeurs agressives chez l’Homme. La plupart des connaissances actuelles sur sa régulation catalytique repose sur des données structurales de cristallographie qui ont révélé l’importance des interactions intramoléculaires SH2 et

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26

Siontas, Dora. "The identification of proteins that interact with the N-terminal domain of Pitx2c." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106609.

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During embryogenesis, a number of key events regulate the correct patterning of an organism, one of them being the correct positioning of internal organs. One of the factors important for this process is the homeodomain transcription factor Pitx2c,which is asymmetrically expressed in the left lateral plate mesoderm. Previous work has shown that the N-terminal domain of Pitx2c is important for left-right patterning, in that overexpression of the N-terminus randomizes the direction of heart tube looping. It is believed that the overexpressed N-terminus is antagonizing the activity of endogenous

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27

De, Mol Eva. "Structure, dynamics and interactions of the N-terminal domain of the androgen receptor." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/147275.

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Prostate cancer (PCa) is the second most common cancer in men after lung cancer. Around 1.1 million men worldwide were diagnosed with PCa in 2012. PCa depends essentially on androgen stimulation for growth and cell survival. The androgen receptor (AR) is a nuclear hormone receptor that is activated by androgenic hormones and the protein through which the physiological effects of androgens are mediated. The AR is necessary for normal prostate development, growth and physiology but also has an important role in the progression of PCa. It is an essential regulator of tumor growth, spread and surv

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28

Hosszu, Laszlo L. P. "NMR studies on the folding of the N-terminal domain of phosphoglycerate kinase." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242283.

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29

Fukuda, Hirofumi. "Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association." Kyoto University, 2020. http://hdl.handle.net/2433/253208.

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30

Mann, Rosalind Jane. "Selective peptide binding determinants on the N-terminal domain of parathyroid hormone receptors." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485164.

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The focus of this PhD work was to elucidate the mechanisms by which PTH2R mediates its ligand binding selectivity. The approach taken was to create a chimeric PTH creceptor with the aim of removing the selectivity filter from the PTH2R so that it would bind PTHrP(1-36). As residue 23 from PTHrP (shown to be responsible for its binding selectivity) has been cross linked to the extreme N-terminal region of the PTH1R, residues 1-41 from this receptor were introduced into the PTH2R. As both receptors bind PTH(1-34), it was expected that this chimeric receptor would also bind the ligand normally bu

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31

South, Timothy E. "Cross-talk between the TonB and TolA Energy Transduction Systems in Escherichia coli." Bowling Green State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1249593545.

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32

Guo, Liang. "Crystallographic and biochemical characterization of human histone deacetylase 4 N-terminal glutamine-rich domain." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3256451.

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33

Rogers, Aaron Bethea. "Translational Fidelity of a Eukaryotic Glutaminyl-tRNA Synthetase with an N-terminal Domain Appendage." Thesis, Portland State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1568586.

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<p> Several <i>Saccharomyces cerevisiae</i> mutant tRNA-<sup> Q2</sup> species (glutamine isoacceptor, CUG anticodon) were synthesized and assayed for aminoacylation activity with <i>Saccharomyces cerevisiae </i> glutaminyl-tRNA synthetase. The derived steady state parameters were compared to similar datasets from the literature. The mutants behaved analogously to similar mutant species based on tRNA from <i>Escherichia coli</i>, but with slightly relaxed specificity as revealed by comparison of <i>k</i><sub>cat</sub>/<i>K</i><sub>M</sub> values relative to wild type <i>in vitro</i> transcri

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34

Watkins, Harriet A. "Characterisation of the soluble N terminal domain of the corticotropin releasing hormone receptor 1." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247650.

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35

Easthon, Lindsey. "Conformational analysis of E. coli DnaT and the complex with PriA N-terminal domain." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271434912.

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36

Erlich, Paul. "Rôle du domaine N-terminal de la PrP dans la pathogenèse des maladies à prions." Phd thesis, Université Joseph Fourier (Grenoble), 2009. http://tel.archives-ouvertes.fr/tel-00433136.

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Le rôle du domaine N-terminal (N-ter) de la protéine PrP dans le processus de conversion de la PrPc en un isoforme infectieux PrPSc est mal connu. L'objectif de ma de thèse a été de créer un prion synthétique composé de la partie N-ter de PrP et de la protéine Doppel (Dpl) pour mieux appréhender le rôle de cette région dans les mécanismes d'agrégation et de pathogenèse des maladies à prions. Trois protéines chimériques PrP/Dpl recombinantes ont été exprimées, purifiées et agrégées in vitro à en oligomères. Ces oligomères solubles présentent des caractéristiques biochimiques et structurales sim

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37

Nylander, Åsa, Gunnel Svensäter, Dilani B. Senadheera, Dennis G. Cvitkovitch, Julia R. Davies, and Karina Persson. "Structural and functional analysis of the N-terminal domain of the Streptococcus gordonii adhesin Sgo0707." Umeå universitet, Oral mikrobiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-71563.

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The commensal Streptococcus gordonii expresses numerous surface adhesins with which it interacts with other microorganisms, host cells and salivary proteins to initiate dental plaque formation. However, this Gram-positive bacterium can also spread to non-oral sites such as the heart valves and cause infective endocarditis. One of its surface adhesins, Sgo0707, is a large protein composed of a non-repetitive N-terminal region followed by several C-terminal repeat domains and a cell wall sorting motif. Here we present the crystal structure of the Sgo0707 N-terminal domains, refined to 2.1 Å reso

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38

Fisher, Carl Albert. "Determination of the lipid-bound conformation of the N-terminal domain of human apolipoprotein E." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0014/NQ59958.pdf.

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39

Norwood, Fiona Lucinda Margaret. "Biochemical and structural studies on the actin binding N-terminal domain of the dystrophin protein." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314010.

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40

Berjanskii, Mark. "Structure and dynamics of the N-terminal J-domain of T antigens of murine polyomavirus." MU online access free, to others for fee Free online access, 2002. http://wwwlib.umi.com/cr/mo/preview?3052146.

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41

Courtois-Cox, Stéphanie. "DeltaNp53, une isoforme du suppresseur de tumeur p53 : découverte, caractérisation et fonctions biologiques." Paris 7, 2003. http://www.theses.fr/2003PA077207.

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42

Quraishi, Omar. "Expression, purification, and NRM characterization of the N-terminal SH2 domain of protein tyrosine phosphatase 1C." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55525.

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The N-terminal SH2 domain of protein tyrosine phosphatase 1C (SHN1C) was expressed in E. coli as a fusion to maltose-binding protein (MBP) using two different polylinkers, one comprising of the traditional recognition motif for FXa (IEGR) and the other for thrombin (FNPR), as part of an effort to resolve its three-dimensional solution structure by NMR spectroscopy. The construct encoding the thrombin cleavage site provided a fusion protein that exhibited superior proteolytic cleavage efficiency. This allowed the production of sufficient SHN1C to allow us to examine its behavior in aqueous solu

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43

Lolle, Susan Janne. "Expression of killer preprotoxin cDNA in Saccharomyces cerevisiae : functional analysis of the N-terminal leader domain." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75435.

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Expression of cDNA clones of the M1 double-stranded RNA killer preprotoxin coding region in Saccharomyces cerevisiae successfully directed the synthesis of secreted active toxin. Transformants harbouring these expression plasmids also displayed a K1 specific immunity phenotype. Immunoprecipitation of intracellular proteins with antitoxin antiserum showed that these transformants synthesize a 42kd glycosylated preprotoxin precursor. Two smaller unglycosylated immunoreactive species could also be resolved. These toxin precursor species were characterized by using secretory-defective hosts, by co

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44

Pudney, Alexander F. "Role of the Usher N-terminal Domain in Assembly of Fl Polymeric Antigen of Yersinia pestis." Thesis, University of Reading, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487475.

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The fraction 1 antigenic capsule of Yersinia pestis is a homopolymer assembled by the two-component chaperone-usher system; a terminal branch of the general secretory pathway. A periplasmic chaperone (CaflM) is responsible for folding and capping of monomeric Cafl, whilst preserving it in an energy competent conformation for fiber formation. Translocation of Cafl polymer to the cell surface occurs via the outer membrane usher CaflA, and circumstantial evidence suggests that polymerisation is catalysed by the usher. Recovery of OlT-sensitive CaflT10CT139C polymer at the surface of recombinant E

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45

Jelinska, Clare. "Equilibrium and kinetic studies of folding and unfolding of the N-terminal domain of phosphoglycerate kinase." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251557.

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46

Künzli, Sandra. "Klonierung und Expression der N-terminalen Domäne des Serotonin-5HT₃-Rezeptors." Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Departement Angewandte Biowissenschaften, Institut für Pharmazeutische Wissenschaften, 2002. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=76.

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47

Bour, Gaétan Egly Cécile. "Le domaine N-terminal des recepteurs nucléaires des rétinoïdes Phosphorylation et mise en évidence de nouveaux corégulateurs /." Strasbourg : Université Louis Pasteur, 2007. http://eprints-scd-ulp.u-strasbg.fr:8080/secure/00000619/01/Bour2006.pdf.

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48

Bour, Gaétan. "Le domaine N-terminal des recepteurs nucléaires des rétinoïdes : Phosphorylation et mise en évidence de nouveaux corégulateurs." Université Louis Pasteur (Strasbourg) (1971-2008), 2006. https://publication-theses.unistra.fr/restreint/theses_doctorat/2006/BOUR_Gaetan_2006.pdf.

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Les rétinoïdes (dérivés de la vitamine A) agissent via deux familles de récepteurs nucléaires: les RAR (α, β, γ) et les RXR (α, β, γ). Ces récepteurs sont des activateurs de la transcription inductibles par leur ligand dont l'activité est régulée par le recrutement dynamique de complexes protéiques au niveau de leur domaine AF-2. Il a été démontré récemment dans l'équipe que les RAR sont aussi des cibles pour des processus de phosphorylation. J'ai montré que l'efficacité de la phosphorylation du domaine AF-1 par la kinase cdk7 dépend de la fixation, au niveau du domaine AF-2, de la cycline H a

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49

Busch, Julia Maria Christiane. "The making and breaking of SAS-6 : structural insights and inhibitor search for n-terminal domain dimerisation." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:2d5e4713-e645-40e9-87a1-88a7425d93eb.

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SAS-6 is the structural core of the forming centriole - a cylindrical protein complex, which is an essential component of the centrosome. Oligomerisation of SAS-6 is crucial for successful centriole duplication and is achieved through two dimerisation domains in the SAS-6 protein; a long C-terminal coiled-coil domain and a globular N-terminal dimerisation domain. As core components of the centrosome, centrioles help facilitate various cellular functions. They are involved in the anchoring of flagella and cilia to the membrane and in coordinating the spindle apparatus during chromosome segregat

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50

Guihot, Jeanne. "Contribution du domaine N-terminal de Mad1 à ses fonctions en mitose et en interphase chez Drosophila melanogaster." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC188/document.

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Mad1 est une protéine clé du point de contrôle du fuseau en mitose. Associée à Mad2,elle est recrutée aux kinétochores non-attachés où elle y catalyse la production du complexe inhibiteur d’anaphase. La protéine Mad1 a longtemps été décrite comme étant un simple récepteur de Mad2 aux kinétochores. Certaines études laissaient toutefois entrevoir des rôles additionnels de cette protéine en mitose comme en interphase.Afin d’explorer ces fonctions additionnelles de Mad1, j’ai étudié le phénotype mitotique associé à une déplétion de la protéine par ARN interférence dans des lignées cellulaires S2 d

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