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Journal articles on the topic 'Na't'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

UZUN, Şerife. "Na't Geleneğinde Şeyh Gâlib Örneği." Journal of Turkish Studies 9, Volume 9 Issue 6 (2014): 1093. http://dx.doi.org/10.7827/turkishstudies.6639.

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2

GÜLER, Zülfi. "Ruz U Şeb Redifli Üç Na'T." Journal of Turkish Research Institute, no. 39 (January 1, 2009): 553. http://dx.doi.org/10.14222/turkiyat895.

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3

Mubarok, M. Zaki, Muchlisin Nawawi, and Nailur Rahmawati. "ASMAUL HUSNA DALAM AL QUR’AN." Lisanul Arab: Journal of Arabic Learning and Teaching 10, no. 1 (2021): 27–36. http://dx.doi.org/10.15294/la.v10i1.48208.

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The aims of this study are: (1) to describe the morphological formation of Asmaul Husna; (2) describe the Asmaul Husna slot; (3) describe the Asmaul Husna pattern model; (4) describe the case and the syntactic function of Asmaul Husna; (5) describe the grammatical markers on Asmaul Husna in the Qur'an. This research is an analysis of Asmaul Husna's morphosyntactic in the Qur'an. This research is a qualitative research with library research design. The data of this research are presented with the consideration sample technique. In this study, from 156 data of Asmaul Husna found 3 data ism jamid

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4

Sharofova, Maxliyo Shokirjon qizi. ""XAMSA" DOSTONLARI NA'T BOBLARINING ISLOM TARIXI BILAN MUTANOSIBLIGI." Educational Research in Universal Sciences 2, no. 4 (2023): 889–95. https://doi.org/10.5281/zenodo.7904958.

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Ushbu maqola sharqning buyuk mutafakkiri Alisher Navoiyning “Xamsa” asari va uning tarkibidagi na’t boblarining islom tarixi bilan mutanosibligi yoritib berilgan. Tadqiqotning maqsadi doston tarkibidagi hamd va na’tlarni tahlil qilish orqali ularning dostondagi o‘rnini belgilash hamda sharq klassik adabiyoti na’munalarini hamd va na’tlarsiz to‘laqonli tushunib bo‘lmasligini isbotlashdan iborat.

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5

Sarıkaya, Meliha Yıldıran. "Yahyâ Kemâl'in Söz Meydanı Şiiri Bir Na't-ı Şerîf Olarak Okunabilir mi?" Divan Edebiyatı Araştırmaları Dergisi 1, no. 24 (2020): 555–87. http://dx.doi.org/10.15247/dev.2807.

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6

Shahlola, Safarova. "SOURCES AND ART OF THE STORIES IN THE SADDI ISKANDARI EPIC." European Journal of Higher Education and Academic Advancement 1, no. 8 (2024): 63–66. https://doi.org/10.61796/ejheaa.v1i8.851.

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In the article, the chapter of praise in "Saddi Iskandari" from the "Khamsa" epics, which occupies a special place in the works of Alisher Navoi, is analyzed ideologically and artistically. During the analysis, attention is paid to the sources of the thoughts presented in the verses, that is, the Holy Qur'an, Hadith Sharif, aspects related to the teachings of Sufism. The poetic lines of the epic are described in prose and analyzed. While analyzing the chapter of Hamd, the formation of special traditions (traditional introductory chapters: basmala, hamd, munojot, na't) in the history of Uzbek l

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7

Aminovna, Safarova Shahlola. "SOURCES AND ART OF THE PRAYER CHAPTERS IN "SABBA'I SAYYOR" AND "SADDI ISKANDARI" EPICS." European International Journal of Philological Sciences 4, no. 5 (2024): 16–20. http://dx.doi.org/10.55640/eijps-04-05-04.

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In the article, the chapter of praise in “Sabba’i Sayyor” and “Saddi Iskandari” from the “Khamsa” epics, which occupies a special place in the works of Alisher Navoi, is analyzed ideologically and artistically. During the analysis, attention is paid to the sources of the thoughts presented in the verses, that is, the Holy Qur'an, Hadith Sharif, aspects related to the teachings of Sufism. The poetic lines of the epic are described in prose and analyzed. While analyzing the chapter of munojat, the formation of special traditions (traditional introductory chapters: basmala, munojat, na't) in the

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8

Bekova, Nazzora Jo'rayevna, and Dildora Istamovna Muxtorova. ""AYN UL -HAYOT" QASIDASI, NASHRLARDAGI TAFOVUTLAR." Educational Research in Universal Sciences 2, no. 5 (2023): 737–45. https://doi.org/10.5281/zenodo.8063910.

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Maqolada Mumtoz she’riy janrlarning eng qadimiylaridan biri                 bo‘lgan  qasida janri xususiyatlari va Alisher Navoiyning na’t qasidasi bo‘lmish “Ayn ul   hayot “ qasidasi  haqida so‘z boradi.

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9

ESİN, Osman. "FUZULÎ'NİN KASİDE DER-NA'T-I HAZRETİ NEBEVİ'SİNİN ÜSLUP ÖZELLİKLERİ VE ŞAİRİN SU REDİFİNİ KULLANMA NEDENLERİ." Journal of International Social Research 13, (13/72) Language-Literature (2020): 85–101. http://dx.doi.org/10.17719/jisr.10879.

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10

Naveed Hussain Iqbal. "طاہر سُلطانی کی نعتیہ شاعری میں تذکرۂ دُرود و سلام". Al-Qamar 4, № 1 (2021): 201–16. https://doi.org/10.53762/kfwcb103.

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Urdu Poetry has a distinct among its so many other forms. Among them Na'at has gained a unique, sacred and dominating place all over the other forms. The Poets consider it an honour for them to write Na'at-e-Nabi (S.A.W). While writing the Na'at they consciously try to write about the life and characteristics of the Holy Prophet Hazrat Muhammad (S.A.W). They also write about Darood-o-Salam which the Allah Almighty has made an obligation for the Muslims. Darood is the most important subject of the poet and most of his poetry is relevant to it. Tahir Sultani belongs to the district Karachi, is a

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11

Mukhitdinova, Nazmiya. "TRADITIONS OF ALISHER NAVOI IN THE DEVAN OF SADOI AND GAZI(ON THE EXAMPLE OF GAZELLES ON THE THEMES OF HAMD, NAAT, MUNOJAT AND MANKABAT)." INTERNATIONAL JOURNAL OF ALISHER NAVOI 1, no. 2 (2021): 138–48. http://dx.doi.org/10.26739/2181-1490-2021-2-16.

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Literary continuity is a unique cultural, high-level literary phenomenon in which the concepts of creative inspiration, imitation and the continuation of great talent are one of the most important features of Eastern classical literature. Regardless of which branch of art is formed in this cultural and literary process, it becomes clear that the main goal is to "renew", learning "from the past" and developing their ideas and artistic abilities. The article examines the issues of tradition and originality of poems by Mirhasan Sadoi and Muhammad Gazi, who grew up in the workshop of Alisher Navoi

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12

Karsono, Ramadhan, Denni Joko Purwanto, Samuel J. Haryono, et al. "Preoperative Neoadjuvant Hormonal Therapy and Neoadjuvant Chemotherapy for Stage 3B and 4 Breast Cancer Patients in Dharmais Hospital-National Cancer Center, Indonesia: A Cohort Study." Indonesian Journal of Cancer 12, no. 4 (2019): 109. http://dx.doi.org/10.33371/ijoc.v12i4.604.

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Background: There are no data of efficacy comparison between primary systemic therapy in stage 3B and 4 breast cancer patients in Indonesia. This study compared long term outcomes of breast cancer patients treated with neoadjuvant hormonal therapy (NAHT) and those treated with neoadjuvant chemotherapy (NACT)Methods: This was a cohort study conducted from 2011 to 2017. A total of 122 patients with stage 3B and 4 breast cancer received NAHT (n = 62) or NACT (n = 60) within a 6 cycles for NACT and 6 months for NAHT were included. Patients were excluded if they had a mastectomy before treatment, w

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13

Haussmann, Jan, Wilfried Budach, Carolin Nestle-Krämling, et al. "Predictive Factors of Long-Term Survival after Neoadjuvant Radiotherapy and Chemotherapy in High-Risk Breast Cancer." Cancers 14, no. 16 (2022): 4031. http://dx.doi.org/10.3390/cancers14164031.

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Background: Neoadjuvant radiotherapy (naRT) in addition to neoadjuvant chemotherapy (naCT) has been used for locally advanced, inoperable breast cancer or to allow breast conserving surgery (BCS). Retrospective analyses suggest that naRT + naCT might result in an improvement in pathological complete response (pCR rate and disease-free survival). pCR is a surrogate parameter for improved event-free and overall survival (OS) and allows for the adaption of the post-neoadjuvant therapy regimens. However, it is not clear whether pCR achieved with the addition of naRT has the same prognostic value.

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14

Tomassi-Morawiec, Hanna, Jacek Wachowiak, and Grzegorz Czapowski. "GEOCHEMIA I WYKSZTAŁCENIE SKAŁ ZUBROWYCH GÓRNEGO PERMU (CECHSZTYN) Z OBSZARU POLSKI." Biuletyn Państwowego Instytutu Geologicznego 477 (2019): 69–122. http://dx.doi.org/10.7306/bpig.49.

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Praca prezentuje wyniki szczegółowych badań składu chemicznego skał zubrowych dwu głównych wydzieleń litostratygraficznych w cyklotemowej sukcesji osadów polskiego cechsztynu: zubra brunatnego (Na3t; cyklotem PZ3) i zubra czerwonego (Na4t; cyklotem PZ4) oraz innych cechsztyńskich ogniw i formacji zubrowych wyróżnionych na obszarze Polski. Skały te opróbowano w 2 wysadach solnych (Kłodawa i Mogilno) oraz w profilach 7 otworów wiertniczych. Utwory Na3t w wysadzie Kłodawa cechuje wyższy udział halitu w porównaniu ze skałami Na4t, które zawierają więcej materiału terygenicznego (materiał detrytycz

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15

Mahbubah, Sihhatul, and Muflihah. "Bentuk-Bentuk Interferensi Sintaksis Bahasa Indonesia Terhadap Bahasa Arab Pada Naskah Soal MFQ MTQ Nasional XXVI." Studi Arab 12, no. 1 (2021): 65–76. http://dx.doi.org/10.35891/sa.v12i1.2541.

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Arabic is a foreign language that still survives its existence to this day. as a foreign language Arabic has the opportunity to be influenced by Indonesian as the first language. This interference is an inevitability but also should not be ignored. therefore, this research was conducted to describe forms of interference, especially in the realm of syntax. research object is a text about MFQ MTQ National XXVI. This research is descriptive qualitative and quantitative research. The main data of this research is the MFQ MTQ National XXVI. Data were collected by using the observation method and th

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16

İnan, Ömer Suat. "KONYALI ACZÎ’YE AİT BİR NAʻT-I MEVLÂNÂ". Osmanli Mirasi Arastirmalari Dergisi 11, № 29 (2024): 23–40. http://dx.doi.org/10.17822/omad.1458214.

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Edebiyatımızda şairler tarafından Hz. Muhammed’i (sav) övmek maksadıyla yazılan şiirlere naat ismi verilmiştir. Zamanla naat başlığı altında diğer din ve tasavvuf büyükleri için de övgüler yazılmıştır. Bu başlık altında hakkında methiye yazılan şahsiyetlerden biri de büyük mutasavvıf şair Mevlâna Celâleddin-i Rûmî’dir (ö. 672 / 1273). 1882-1965 yılları arasında Konya’da yaşamış olan yazar, ressam ve şair gibi nitelikleri haiz İbrahim Aczî Kendi, edebiyat ve tasavvuf tarihinde çok önemli bir yere sahip olan, ünü sınırları ve zamanı aşan Mevlâna için “Der-Na’t-ı Mevlâna-yı bî-hem-tâ Kuddise Sırr

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17

Oktaviana, Anisa Rosi. "Al-Uslūb al-Taqābulī fī Sūrah al-Baqarah wa Dilālatuhu." Journal of Arabic Literature (Jali) 1, no. 2 (2020): 60–67. http://dx.doi.org/10.18860/jali.v1i2.8445.

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The purpose of this study is to explain and identify the conflicting meanings in Arabic. It refers to the Muqabalah Theory in Balaghah, and At-Tadzat in Semantics using Ali Al-Khouli’s opinion, there are also different patterns of sentence contradiction, which justifies the importance of this study. The data were obtained from AL-Qur'an Surah Al-Baqarah. This research employs a descriptive qualitative method. In Balaghah At-Taqabuly or Al-Muqabalah is a sequence of contradictory meanings; while in the Semantics, it is called At-Tadzat which literally means Antonym. In line with the At-Taqabuly

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18

Seu, Windynia. "Pembinaan Ekonomi GMIT Jemaat Bet’el Maulafa dan Jemaat Bethani Naet." Danum Pambelum: Jurnal Teologi Dan Musik Gereja 4, no. 1 (2024): 95–102. https://doi.org/10.54170/dp.v4i1.389.

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The coaching of congregation is one of the church's tasks. The task of the church is to empower the congregation so that the congregation is more empowered to be able to meet their needs, both physical and spiritual. For this reason, this research was conducted to examine congregational empowerment at GMIT Berthany Naet Congregation and GMIT Bethel Maulafa Congregation. The research method used was descriptive qualitative and research information was obtained through Focus Group Discussion (FGD). From the results of the study, the economic empowerment of congregations at GMIT Bethany Na'et Con

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19

Kahl, O. "ANNA CONTADINI, A World of Beasts: A Thirteenth-Century Illustrated Arabic Book on Animals (the Kitab Na't al-Hayawan) in the Ibn Bakhtishu' Tradition." Journal of Semitic Studies 58, no. 2 (2013): 426–29. http://dx.doi.org/10.1093/jss/fgt021.

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20

Di Donna, Mariano Catello, Giuseppe Cucinella, Vincenzo Giallombardo, et al. "Urinary, Gastrointestinal, and Sexual Dysfunctions after Chemotherapy, Radiotherapy, Radical Surgery or Multimodal Treatment in Women with Locally Advanced Cervical Cancer: A Multicenter Retrospective Study." Cancers 15, no. 24 (2023): 5734. http://dx.doi.org/10.3390/cancers15245734.

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Background: Different strategies have been proposed for the treatment of locally advanced cervical cancer (LACC), with different impacts on patient’s quality of life (QoL). This study aimed to analyze urinary, bowel, and sexual dysfunctions in a series of LACC patients who underwent chemotherapy, radiotherapy, radical surgery, or a combination of these treatments. Methods: Patients with LACC who underwent neoadjuvant radio–chemotherapy (NART/CT; n = 35), neoadjuvant chemotherapy (NACT; n = 17), exclusive radio–chemotherapy (ERT/CT; n = 28), or upfront surgery (UPS; n = 10) from November 2010 t

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21

Corti, Chiara, Xiangying Chu, Pedro Exman, et al. "Abstract PO3-01-09: Results of a prospective observational study evaluating the impact of the Prosigna assay on neoadjuvant treatment decision-making in patients with early-stage HR+/HER2- breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO3–01–09—PO3–01–09. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-01-09.

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Abstract Background. Prosigna (PAM50) is an FDA-approved prognostic test that measures the expression of 50 classifier genes in breast cancer tissue samples. It provides intrinsic subtyping, which classifies the biology of an individual patient's tumor, as well as a risk of recurrence (ROR) score that predicts the probability of distant recurrence over 10 years. Currently, the Prosigna assay is only approved for use in postoperative specimens. Given studies demonstrating that Prosigna can identify tumors that are more likely to benefit from chemotherapy, this decision-impact study sought to ev

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22

Volchenko, Nadezhda, A. Bosieva, A. Zikiryakhodzhayev, and M. Ermoshchenkova. "THE MODERN ASPECTS OF THE BREAST CONSERVING SURGERY AFTER NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH BREAST CANCER CT1-3N0-3M0." Problems in oncology 66, no. 4 (2020): 376–80. http://dx.doi.org/10.37469/0507-3758-2020-66-4-376-380.

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Introduction. While the “no tumor on ink” approach is generally accepted for breast-conserving surgery (BCS) in patient with breast cancer, it remains unclear whether it is oncologically safe for BCS after neoadjuvant chemotherapy therapy (NACT). The aim of the study is to investigate the optimal width of the resection edges in BCS after NALT and the influence on disease-free and overall survival in patients with breast cancer. Materials and methods. Retrospectively, the medical documentation of 76 patients with breast cancer, who were performed BCS after NACT, was studied. The distribution by

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23

Prigarina, N. I. "Linking the poetical text and the doctrines of Sufi brotherhoods: Sufi poetry of A. Lahuti." Orientalistica 2, no. 4 (2020): 1021–37. http://dx.doi.org/10.31696/2618-7043-2019-2-4-1021-1037.

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The article deals with the poetical heritage of Abulqasim Lahuti, more precisely his poetical works of an early period, which constitute a special section in his collection of poems, the Divan. It was published in Teheran as early as in 1979 by 'Ali Bashiri under the title As'ar-e mazhabi va 'erfani («Religious and Sufi verses»). The revolutionary, patriotic and lyrical poetical works by A. Lahuti published since 1909 are well-known. However, his early poetry, which reflects the time when he was in contact with various Sufi brotherhoods remains almost a terra incognita for most scholars who ha

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Haussmann, Jan, Wilfried Budach, Carolin Nestle Kraemling, et al. "Determinants of pathological complete response and tumor regression in high-risk breast cancer treated with neoadjuvant radiotherapy and chemotherapy." Journal of Clinical Oncology 42, no. 16_suppl (2024): e12652-e12652. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e12652.

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e12652 Background: Pathological complete response (pCR) is a recognized prognostic indicator in breast cancer patients undergoing neoadjuvant systemic therapy (naST). Known determinants of pCR include intrinsic subtype, proliferation index, grading, clinical tumor and nodal stage, as well as the type of systemic therapy. Incorporating neoadjuvant radiotherapy (naRT) may enhance response rates, disease-free survival, toxicity profiles, and cosmetic outcomes compared to adjuvant radiotherapy. However, the factors influencing pCR and primary tumor regression with the addition of neoadjuvant radio

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25

Jha, Rohit Kumar, Shalini Kumari, Sumedha Gargy, Rajen A Tankshali, and Kiran C Kothari. "Surgical outcomes of neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy in patients of locally advanced carcinoma of esophagus: A prospective cross-sectional comparative study." Asian Journal of Medical Sciences 15, no. 2 (2024): 202–7. http://dx.doi.org/10.3126/ajms.v15i2.58705.

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Background: Neoadjuvant chemoradiotherapy + radiotherapy (NACT+RT) or neoadjuvant chemotherapy (NACT) has been shown to improve survival in locally advanced esophageal carcinoma (EC). Comparative evaluation of NACT+RT versus NACT is ambiguous. Aims and Objectives: The current study was designed to evaluate the outcomes of NACT+RT versus NACT in locally advanced EC. Materials and Methods: In this prospective cross-sectional study, patients with operable, non-metastatic squamous cell carcinoma, and adenocarcinoma of the mid and lower esophagus (T3–T4a) were treated with NACT (paclitaxel 175 mg/m

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26

Liang, Bin, Lisa Hyland, and Sam Hou. "Nasal-Associated Lymphoid Tissue Is a Site of Long-Term Virus-Specific Antibody Production following Respiratory Virus Infection of Mice." Journal of Virology 75, no. 11 (2001): 5416–20. http://dx.doi.org/10.1128/jvi.75.11.5416-5420.2001.

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ABSTRACT Nasal immunoglobulin A provides an initial defense against inhaled respiratory pathogens. However, it is not known whether the nasal-associated lymphoid tissues (NALT) are able to mount an effective long-lasting pathogen-specific immune response, nor is it known whether functional differences exist between the organized NALT (O-NALT) and the diffuse NALT lining the nasal passages (D-NALT). Here we show that although both the O-NALT and the D-NALT are capable of producing virus-specific antibody in response to influenza virus infection, the frequency of specific antibody-forming cells

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27

Yamada, Yota, Motoyasu Miyazaki, Hisako Kushima, et al. "Impact of Nucleic Acid Amplification Test on Clinical Outcomes in Patients with Clostridioides difficile Infection." Antibiotics 12, no. 3 (2023): 428. http://dx.doi.org/10.3390/antibiotics12030428.

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A nucleic acid amplification test (NAAT) is recommended to determine whether or not patients have a Clostridioides difficile infection (CDI) when the glutamate dehydrogenase activity assay is positive and the rapid membrane enzyme immunoassays for toxins is negative. In our hospital, a NAAT was introduced to diagnose CDI precisely in April 2020. This study aimed to investigate the impact of a NAAT on the clinical outcomes in patients with CDI at our hospital. Seventy-one patients diagnosed with CDI between April 2017 and March 2022 were included in our study. Patients with CDI were divided int

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28

BRIGHT, PETER, ELI JALDOW, and MICHAEL D. KOPELMAN. "The National Adult Reading Test as a measure of premorbid intelligence: A comparison with estimates derived from demographic variables." Journal of the International Neuropsychological Society 8, no. 6 (2002): 847–54. http://dx.doi.org/10.1017/s1355617702860131.

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Since its publication in 1982, the National Adult Reading Test (NART; Revised Version, NART–R) has become a widely accepted method for estimating premorbid levels of intelligence in neuropsychological research. However, the assumption that NART/NART–R performance is relatively independent of brain damage has been increasingly challenged in recent years. In a number of conditions, including Alzheimer dementia and Korsakoff's syndrome, studies have indicated a deterioration in reading ability, leading to an underestimated premorbid IQ. In a reaction to these studies, some researchers have advoca

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Liu, Liang Chih, Tzong-Der Way, Chin-Hua Lin, et al. "A proof-of-concept study of LXP5268 as an add-on neoadjuvant chemotherapy in patients with early-stage triple-negative breast cancer." Journal of Clinical Oncology 42, no. 16_suppl (2024): e12607-e12607. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e12607.

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e12607 Background: Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive subtype characterized by a high risk of mortality and a poor prognosis. The 2019 ASCO and St. Gallen International Consensus Guidelines strongly recommend neoadjuvant chemotherapy (NACT) for early-stage TNBC. Previous studies indicated that NACT improved overall and disease-free survival in early-stage TNBC. LXP5268, a drug in the 505(b)(2) category, has demonstrated efficacy in reducing tumor size in animal models. Our study aims to assess whether combining LXP5268 with NACT enhances anti-tumor efficacy

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30

Skarping, Ida, Daniel Förnvik, Sophia Zackrisson, Signe Borgquist, and Lisa Rydén. "Predicting pathological axillary lymph node status with ultrasound following neoadjuvant therapy for breast cancer." Breast Cancer Research and Treatment 189, no. 1 (2021): 131–44. http://dx.doi.org/10.1007/s10549-021-06283-8.

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Abstract Purpose High-performing imaging and predictive markers are warranted to minimize surgical overtreatment of the axilla in breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Here we have investigated whether axillary ultrasound (AUS) could identify axillary lymph node (ALN) metastasis (ALNM) pre-NACT and post-NACT for BC. The association of tumor, AUS features and mammographic density (MD) with axillary-pathological complete response (axillary-pCR) post-NACT was also assessed. Methods The NeoDense-study cohort (N = 202, NACT during 2014–2019), constituted a pre-NACT

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O'Carroll, R. E., A. Moffoot, K. P. Ebmeier, and G. M. Goodwin. "Estimating pre-morbid intellectual ability in the Alcoholic Korsakoff Syndrome." Psychological Medicine 22, no. 4 (1992): 903–9. http://dx.doi.org/10.1017/s0033291700038472.

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SynopsisThe National Adult Reading Test (NART) is widely used in clinical and research settings to estimate pre-morbid intellectual levels. The validity of the NART in estimating pre-morbid ability in Alcoholic Korsakoff Syndrome (AKS) is examined in the present study. Twenty AKS subjects were compared with 40 healthy controls. The validity of the NART as a pre-morbid measure in AKS was examined using four methods. AKS subjects made more NART errors than controls, had lower NART predicted IQ than demographically predicted IQ, made more NART errors than predicted by demographic variables and de

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Menshenina, Anna P., Elena P. Ulianova, Evgeniya M. Nepomnyashchaya, et al. "Characteristics of expression of cancer stem cell markers in various approaches to cervical cancer treatment." Journal of Clinical Oncology 40, no. 16_suppl (2022): e17516-e17516. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17516.

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e17516 Background: Cancer stem cells (CSCs) are being actively studied as a possible origin of malignant neoplasms. Research of the properties of CSCs and mechanisms of their regulation holds the promise of the development of new approaches to antitumor therapy. The most frequently detected CSC markers in different tumors are CD44 and CD133. In this regard, the aim of our study was to identify characteristics of expression of CSC markers in cervical cancer treatment and their possible predictive value. Methods: The study included 237 patients with locally advanced cervical cancer T2a-2bNx-1M0.

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Abdel-Fatah, Tarek Mohamed Ahmed, Rebekah Webb, Ruizhe Li, et al. "Evidence that neoadjuvant anthracycline based combination chemotherapy (NACT) in breast cancer (BC) induces phenotypical changes which guides the optimal adjuvant therapy." Journal of Clinical Oncology 37, no. 15_suppl (2019): 590. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.590.

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590 Background: We hereby evaluated the histopathological and radiological alterations of tumor characteristics after receiving NACT and the clinical significance of the changes of adjuvant therapy based on these findings. Methods: A pathological assessment of tumor features including ER, PR, HER2 and proliferation markers (Ki67 and SPAG5) status in pre and post NACT tumors tissue have been centrally evaluated in two cohorts [Nottingham University Hospital (NUH; n=850) and Australian cohort (n=250 patients)]. Since 2013 any change in the ER and HER2 status from negative (-) [in the pre NACT bi

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Koulis, T. A., K. Beecham, C. Speers, et al. "Neoadjuvant systemic therapy in breast cancer: use and trends in radiotherapy practice." Current Oncology 24, no. 5 (2017): 310. http://dx.doi.org/10.3747/co.24.3558.

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BackgroundThe use of neoadjuvant systemic therapy (nast) in the treatment of breast cancer is increasing, and the role of adjuvant radiation therapy (rt) in that setting is uncertain. We sought to review and report the use of nast, its trends over time, and its relationship with the prescribing patterns of locoregional rt in a provincial cancer system.Methods Patients with stages i–iii breast cancer diagnosed during 2007–2012 were identified using a provincial database. Patient, tumour, and treatment characteristics were extracted. Multivariable logistic regression analyses were used to assess

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Sandlund, Johanna, Joel Estis, Phoebe Katzenbach, et al. "2356. Increased Clinical Specificity with Ultrasensitive Detection of Clostridioides difficile Toxins: Reduction of Overdiagnosis Compared with Nucleic Acid Amplification Tests." Open Forum Infectious Diseases 6, Supplement_2 (2019): S811—S812. http://dx.doi.org/10.1093/ofid/ofz360.2034.

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Abstract Background Clostridioides difficile infection (CDI) is one of the most common healthcare-associated infections, resulting in significant morbidity, mortality, and economic burden. Diagnosis of CDI relies on the assessment of clinical presentation and laboratory tests. We have evaluated the clinical performance of ultrasensitive Single Molecule Counting technology for detection of C. difficile toxins A and B. Methods Stool specimens from 298 patients with suspected CDI were tested with nucleic acid amplification test (NAAT; BD MAX™ Cdiff assay or Xpert® C. difficile assay) and Singulex

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Welford, Elliott, Thomas C. S. Martin, Natasha K. Martin, Winston Tilghman, and Susan J. Little. "Relative Cost and Infectious Days Averted Associated With Rapid Gonorrhea and Chlamydia Testing Among Men Who Have Sex With Men." Sexually Transmitted Diseases 51, no. 6 (2024): 388–92. http://dx.doi.org/10.1097/olq.0000000000001956.

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Background Standard-of-care nucleic acid amplification tests (routine NAATs) for Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) can take several days to result and therefore delay treatment. Rapid point-of-care GC/CT NAAT (rapid NAAT) could reduce the time to treatment and therefore onward transmission. This study evaluated the incremental cost per infectious day averted and overall cost of implementation associated with rapid compared with routine NAAT. Methods Prospective sexually transmitted infection (STI) treatment data from men who have sex with men and transgender women in Sa

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Liu, Chia-Hao, Yu-Chieh Lee, Jeff Chien-Fu Lin, et al. "Radical Hysterectomy After Neoadjuvant Chemotherapy for Locally Bulky-Size Cervical Cancer: A Retrospective Comparative Analysis between the Robotic and Abdominal Approaches." International Journal of Environmental Research and Public Health 16, no. 20 (2019): 3833. http://dx.doi.org/10.3390/ijerph16203833.

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Radical hysterectomy (RH) is the standard treatment for early stage cervical cancer, but the surgical approach for locally bulky-size cervical cancer (LBS-CC) is still unclear. We retrospectively compared the outcomes of women with LBS-CC treated with neoadjuvant chemotherapy (NACT) and subsequent RH between the robotic (R-RH) and abdominal approaches (A-RH). Between 2012 and 2014, 39 women with LBS-CC FIGO (International Federation of Gynecology and Obstetrics) stage IB2–IIB were treated with NACT-R-RH (n = 18) or NACT-A-RH (n = 21). Surgical parameters and prognosis were compared. Patient ch

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Tang, Xiao-Huan, Xiao-Long Wu, Xue-Jun Gan, et al. "Using Normalized Carcinoembryonic Antigen and Carbohydrate Antigen 19 to Predict and Monitor the Efficacy of Neoadjuvant Chemotherapy in Locally Advanced Gastric Cancer." International Journal of Molecular Sciences 24, no. 15 (2023): 12192. http://dx.doi.org/10.3390/ijms241512192.

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Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are established prognostic biomarkers for patients with gastric cancer. However, their potential as predictive markers for neoadjuvant chemotherapy (NACT) efficacy has not been fully elucidated. Methods: We conducted a retrospective analysis to determine values of CEA and CA19-9 prior to NACT (pre-NACT) and after NACT (post-NACT) in 399 patients with locally advanced gastric cancer (LAGC) who received intended NACT and surgery. Results: Among the 399 patients who underwent NACT plus surgery, 132 patients (33.1%) had elevated

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Shea, Stephanie M., Gopi Patel, Sarah Schaefer, et al. "421. If at first you do not succeed…. Repeat SARS-COV2 PCR testing." Open Forum Infectious Diseases 7, Supplement_1 (2020): S277—S278. http://dx.doi.org/10.1093/ofid/ofaa439.615.

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Abstract Background Nucleic Acid Amplification Tests (NAATs) of nasopharyngeal specimens (NPS) have become standard for diagnosis of SARS-COV2. IDSA guidelines suggest repeat testing after 24–48 h when initially negative and clinical suspicion persists. We characterized patients from whom initial NPS were NAAT-negative, but repeats were NAAT-positive, in order to identify which patients might benefit from repeat NAAT for SARS-CoV-2, and the appropriate interval. Methods We conducted an IRB-approved retrospective review of laboratory and electronic medical record data for all patients evaluated

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Csencsits, Keri L., Mark A. Jutila, and David W. Pascual. "Nasal-Associated Lymphoid Tissue: Phenotypic and Functional Evidence for the Primary Role of Peripheral Node Addressin in Naive Lymphocyte Adhesion to High Endothelial Venules in a Mucosal Site." Journal of Immunology 163, no. 3 (1999): 1382–89. http://dx.doi.org/10.4049/jimmunol.163.3.1382.

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Abstract Nasal-associated lymphoid tissue (NALT), a mucosal inductive site for the upper respiratory tract, is important for the development of mucosal immunity locally and distally to intranasally introduced Ag. To more fully understand the induction of nasal mucosal immunity, we investigated the addressins that allow for lymphocyte trafficking to this tissue. To investigate the addressins responsible for naive lymphocyte binding, immunofluorescent and immunoperoxidase staining of frozen NALT sections were performed using anti-mucosal addressin cell adhesion molecule-1 (MAdCAM-1), anti-periph

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Cardoso, Marcella R., Alex Ap Rosini Silva, Maria Cecília R. Talarico, et al. "Metabolomics by NMR Combined with Machine Learning to Predict Neoadjuvant Chemotherapy Response for Breast Cancer." Cancers 14, no. 20 (2022): 5055. http://dx.doi.org/10.3390/cancers14205055.

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Neoadjuvant chemotherapy (NACT) is offered to patients with operable or inoperable breast cancer (BC) to downstage the disease. Clinical responses to NACT may vary depending on a few known clinical and biological features, but the diversity of responses to NACT is not fully understood. In this study, 80 women had their metabolite profiles of pre-treatment sera analyzed for potential NACT response biomarker candidates in combination with immunohistochemical parameters using Nuclear Magnetic Resonance (NMR). Sixty-four percent of the patients were resistant to chemotherapy. NMR, hormonal recepto

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Cummings, Mackenzie, Olivia Nicolais, and Mark Shahin. "Surgery in Advanced Ovary Cancer: Primary versus Interval Cytoreduction." Diagnostics 12, no. 4 (2022): 988. http://dx.doi.org/10.3390/diagnostics12040988.

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Primary debulking surgery (PDS) has remained the only treatment of ovarian cancer with survival advantage since its development in the 1970s. However, survival advantage is only observed in patients who are optimally resected. Neoadjuvant chemotherapy (NACT) has emerged as an alternative for patients in whom optimal resection is unlikely and/or patients with comorbidities at high risk for perioperative complications. The purpose of this review is to summarize the evidence to date for PDS and NACT in the treatment of stage III/IV ovarian carcinoma. We systematically searched the PubMed database

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Patil, Vijay M., Amit Joshi, Vanita Noronha, et al. "Neoadjuvant Chemotherapy in Locally Advanced and Borderline Resectable Nonsquamous Sinonasal Tumors (Esthesioneuroblastoma and Sinonasal Tumor with Neuroendocrine Differentiation)." International Journal of Surgical Oncology 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/6923730.

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Introduction.Sinonasal tumors are chemotherapy responsive which frequently present in advanced stages making NACT a promising option for improving resection and local control in borderline resectable and locally advanced tumours. Here we reviewed the results of 25 such cases treated with NACT.Materials and Methods. Sinonasal tumor patients treated with NACT were selected for this analysis. These patients received NACT with platinum and etoposide for 2 cycles. Patients who responded and were amenable for gross total resection underwent surgical resection and adjuvant CTRT. Those who responded b

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Ohmichi, Yukari, Jotaro Hirakawa, Yasuyuki Imai, Minoru Fukuda, and Hiroto Kawashima. "Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses." Journal of Experimental Medicine 208, no. 5 (2011): 1015–25. http://dx.doi.org/10.1084/jem.20101786.

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Nasal-associated lymphoid tissue (NALT) is a mucosal immune tissue that provides immune responses against inhaled antigens. Lymphocyte homing to NALT is mediated by specific interactions between lymphocytes and high endothelial venules (HEVs) in NALT. In contrast to HEVs in other mucosal lymphoid tissues, NALT HEVs strongly express peripheral node addressins (PNAds) that bear sulfated glycans recognized by the monoclonal antibody MECA-79. We investigated the role of PNAd in lymphocyte homing to NALT using sulfotransferase N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST) 1 and GlcNAc6ST-2 d

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Higuchi, Kei, Jonathan J. Kopel, Sathish Sivaprakasam, et al. "Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY)." Biochemical Journal 477, no. 21 (2020): 4149–65. http://dx.doi.org/10.1042/bcj20200592.

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The Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY) in the liver delivers citrate from the blood into hepatocytes. As citrate is a key metabolite and regulator of multiple biochemical pathways, deletion of Slc13a5 in mice protects against diet-induced obesity, diabetes, and metabolic syndrome. Silencing the transporter suppresses hepatocellular carcinoma. Therefore, selective blockers of NaCT hold the potential to treat various diseases. Here we report on the characteristics of one such inhibitor, BI01383298. It is known that BI01383298 is a high-affinity inhibitor selective for human NaC

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Wind, Carolien M., Henry J. C. de Vries, Maarten F. Schim van der Loeff, Magnus Unemo, and Alje P. van Dam. "Successful Combination of Nucleic Acid Amplification Test Diagnostics and Targeted Deferred Neisseria gonorrhoeae Culture." Journal of Clinical Microbiology 53, no. 6 (2015): 1884–90. http://dx.doi.org/10.1128/jcm.00369-15.

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Nucleic acid amplification tests (NAATs) are recommended for the diagnosis ofN. gonorrhoeaeinfections because of their superior sensitivity. Increasing NAAT use causes a decline in crucial antimicrobial resistance (AMR) surveillance data, which rely on culture. We analyzed the suitability of the ESwab system for NAAT diagnostics and deferred targetedN. gonorrhoeaeculture to allow selective and efficient culture based on NAAT results. We included patients visiting the STI Clinic Amsterdam, The Netherlands, in 2013. Patient characteristics and urogenital and rectal samples for directN. gonorrhoe

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Choi, Jae-Min, Jong-Koo Lee, Jai-Kyong Pyon, Goo-Hyun Mun, Byung-Joon Jeon, and Kyeong-Tae Lee. "Association of Neoadjuvant Chemotherapy With Postoperative Outcomes in Immediate Prepectoral Prosthetic Breast Reconstruction." Annals of Plastic Surgery 92, no. 5 (2024): 514–21. http://dx.doi.org/10.1097/sap.0000000000003887.

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Purpose Neoadjuvant chemotherapy (NACT) followed by total mastectomy and immediate reconstruction has become an important strategy in the treatment of breast cancer. Although the safety of subpectoral implant-based breast reconstruction with NACT has been extensively evaluated, the safety in prepectoral reconstruction has not been clearly elucidated. We aimed to evaluate the association of NACT with immediate prepectoral breast reconstruction outcomes. Methods A retrospective review of patients who underwent total mastectomy and immediate implant-based prepectoral breast reconstruction between

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McComas, William F. "NABT." American Biology Teacher 84, no. 8 (2022): 455. http://dx.doi.org/10.1525/abt.2022.84.8.455.

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Brown, Alaina J., Marilyn Huang, Charlotte C. Sun, et al. "Benefits of neoadjuvant chemotherapy in ovarian, primary peritoneal, or fallopian tube carcinoma." Journal of Clinical Oncology 31, no. 15_suppl (2013): 5580. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5580.

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5580 Background: NCCN guidelines recommend consideration of neoadjuvant chemotherapy (NACT) for poor surgical candidates with bulky stage III or IV ovarian, fallopian tube, or primary peritoneal cancer. However, new convincing evidence favoring NACT instead of primary tumor reductive surgery (PTRS) has resulted in shifting practices among gynecologic oncologists. This study compares operative and post-operative outcomes between patients receiving NACT and those undergoing PTRS. Methods: After IRB approval, patients who received NACT or PTRS were identified through the tumor registry and surgic

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Salinas, Irene, Benjamin Garcia, Fen Dong, and Elisa Casadei. "Discovery of an organized nasopharynx-associated lymphoid tissue in the nasal cavity of rainbow trout and its role in secondary adaptive immune responses to nasal vaccines." Journal of Immunology 208, no. 1_Supplement (2022): 124.19. http://dx.doi.org/10.4049/jimmunol.208.supp.124.19.

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Abstract The olfactory organ of all vertebrates is constantly exposed to pathogens. The nasal mucosa is therefore equipped with a local immune system that protects the host from infection. In teleost fish, we previously described the presence of a diffuse nasopharynx-associated lymphoid tissue (NALT) found in the olfactory lamellae. This diffuse NALT (d-NALT) consists of myeloid and lymphoid cells but lacks an organized structure. Rainbow trout d-NALT mounts quick innate immune responses as well as adaptive immune responses to nasal vaccines. Here we report the discovery of a novel lymphoid st

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