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Dissertations / Theses on the topic 'NA methylation profiling'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Mirbahai, Leda. "DNA methylation profiling of fish tumours." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3633/.

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Assessment of disease status in fish is used as an indicator of the biological effects of contaminants in the marine environment. At some UK offshore sites the prevalence of liver tumours in Limanda limanda (dab) exceeds 20%. However, the molecular mechanisms of tumour formation and the causative agents are not known. The contribution of epigenetic mechanisms, although well-established in human tumourigenesis, is under-studied in tumours of aquatic species. In this thesis, alteration in the DNA methylation patterns in tumours of two fish species, the model species zebrafish (Danio rerio) and t

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2

Taplin, Christopher David. "Epigenetic profiling of bronchial epithelial cells : DNA methylation." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23483.

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Epigenetic regulation of gene expression is critical for normal human development and cellular differentiation. Although each somatic cell in the human body is genetically identical, epigenetic marks including the DNA methylation pattern are tissue-specific and critical for determining the vast array of cellular phenotypes. For studying respiratory disease, the airway epithelium is the ideal target tissue since it is the first point of contact for inhaled particles, viruses and airborne allergens. Cultured airway epithelial cells of asthmatic children show striking phenotypic differences compa

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Dai, Wei. "Biostatistical analysis of DNA methylation profiling in ovarian cancer." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/7065.

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Ovarian cancer is the most lethal gynaecological cancer. Although having good response to chemotherapy, the majority of the patients with advanced disease will eventually relapse. Aberrant DNA methylation in tumours has been proposed as biomarkers to predict patients’ clinical outcome and response to chemotherapy. An algorithm, Methylation Linear Discriminant Analysis (MLDA), was developed for large-scale methylation analysis using differential methylation hybridsation (DMH). MLDA identified loci differentially methylated between cisplatin sensitive and resistant derivatives of an ovarian tumo

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Bhoi, Sujata. "Prognostic markers and DNA methylation profiling in lymphoid malignancies." Doctoral thesis, Uppsala universitet, Experimentell och klinisk onkologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328616.

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In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. Besides confirming its prognostic impact in multivariate analysis, we could identify 30% of IGHV-mutated CLL (M-CLL)

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Walker, Caroline Gwendolyn. "Genome-wide transcriptional and DNA methylation profiling of the bovine endometrium." Thesis, University of Auckland, 2012. http://hdl.handle.net/2292/19432.

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The aim of this research was to identify key molecular mechanisms regulating early pregnancy events in dairy cattle. Genome-wide gene expression and DNA methylation profiles were characterised in the endometrium of fertile and sub-fertile dairy cows at day 17 of pregnancy and the oestrous cycle. Gene expression data in combination with QTL data was then used to identify candidate genes for genetic analysis. The results of this study identified several biological processes likely to be important contributors to pregnancy success. In particular, genes classified as having roles in immune r

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6

Rahmatpanah, Farahnaz B. Caldwell Charles W. "Large scale CpG island methylation profiling of small B cell lymphoma." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6863.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on April 1, 2010). Vita. Thesis advisor: Charles W. Caldwell. "May 2008" Includes bibliographical references

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Najgebauer, H. "Genome-wide DNA methylation and gene expression profiling of cancer-associated myofibroblasts." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001706/.

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In recent years it has become increasingly apparent that tumour development and metastasis are not simply driven by mutations within cancer cells. Factors produced by stromal myofibroblasts play a key role in the development and metastasis of many forms of cancer. However, our knowledge of the range of molecular mechanisms that drive paracrine communication between cancer and stromal cells remains incomplete. Evidence from previous studies show that myofibroblasts derived from gastric tumours (CAMs) not only retain their ability to enhance the proliferation and migration of cancer cells in vit

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8

Day, Samantha E., Richard L. Coletta, Joon Young Kim, et al. "Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes." BioMed Central, 2016. http://hdl.handle.net/10150/618693.

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Background: Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to investigate the role of skeletal muscle DNA methylation in combination with transcriptomic changes in obesity. Results: Muscle biopsies were obtained basally from lean (n = 12; BMI = 23.4 +/- 0.7 kg/m(2)) and obese (n = 10; BMI = 32.9 +/- 0.7 kg/m(2)) participants in combination with euglycemic-hyperinsulinemic clamps to assess insulin sensitivity. We performed reduced representation bisulfite sequencing (

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9

Gerring, Zachary F. "Integrating genome-wide association and blood genomic profiling data to characterise migraine risk loci." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/112796/1/Zachary_Gerring_Thesis.pdf.

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This thesis involved a multi-staged integrated study of gene expression, DNA methylation, and DNA sequence variation data in a large sample of migraine cases and non-migraine controls. The analysis and integration of these data identified molecular perturbations associated with migraine, and prioritised migraine susceptibility genes for further functional characterisation. The use of multiple molecular data to study existing migraine loci has the potential to provide a substantial contribution to understanding the underlying genetic architecture and biological mechanisms of migraine, and may h

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Cahill, Nicola. "Molecular Genetic and DNA Methylation Profiling of Chronic Lymphocytic Leukaemia : A Focus on Divergent Prognostic Subgroups and Subsets." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-168945.

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Advancements in prognostication have improved the subdivision of chronic lymphocytic leukaemia (CLL) into diverse prognostic subgroups. In CLL, IGHV unmutated and IGHV3-21 genes are associated with a poor-prognosis, conversely, IGHV mutated genes with a favourable outcome. The finding of multiple CLL subsets expressing ‘stereotyped’ B-cell receptors (BCRs) has suggested a role for antigen(s) in leukemogenesis. Patients belonging to certain stereotyped subsets share clinical and biological characteristics, yet limited knowledge exists regarding the genetic and epigenetic events that may influen

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Halldórsdóttir, Anna Margrét. "Genetic and Epigenetic Profiling of Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia." Doctoral thesis, Uppsala universitet, Hematologi och immunologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156786.

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Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) both belong to the group of mature B-cell malignancies. However, MCL is typically clinically aggressive while the clinical course of CLL varies. CLL can be divided into prognostic subgroups based on IGHV mutational status and into multiple subsets based on closely homologous (stereotyped) B-cell receptors. In paper I we investigated 31 MCL cases using high-density 250K single-nucleotide polymorphism arrays and gene expression arrays. Although most copy-number aberrations (CNAs) were previously reported in MCL, a novel deletion w

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Wu, Mengchu. "The Epigenetic Silencing of PMP24 During the Progression of Prostate Cancer from an Androgen-Dependent to Androgen-Independent State in the LNCAP Cell Model: a Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/209.

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One important objective of prostate cancer (PCa) research is to understand the molecular basis underlying the progression of these cancers from an androgen dependent to an androgen independent state. Hypermethylation of the promoter CpG islands is associated with the transcriptional silencing of specific gene sets in each tumor type and subtype. Transcriptional silencing of antitumor genes via CpG island hypermethylation could be a mechanism mediating PCa progression from an androgen-dependent to an androgen-independent state. Hypermethylation associated gene silencing has been reported for a

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13

Su, Sheng-Yao, and 蘇聖堯. "An Integrated Framework for Genome-wide DNA Methylation Profiling." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/5h7frq.

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博士<br>國立陽明大學<br>生物醫學資訊研究所<br>107<br>DNA methylation is one of the best-characterized epigenetic modifications and has been implicated in numerous biological processes, including transposable element silencing, genomic imprinting and X chromosome inactivation. Using whole genome bisulfite sequencing (WGBS) technology, the methylated cytosine sites can be revealed at single nucleotide level. However, the WGBS data analysis process is usually complicated and challenging. To alleviate the associated difficulties, we integrated the data processing steps and downstream analysis into a two-phase app

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Huang, Kuo Hao, and 黃國豪. "Promoter methylation profiling in oral squamous cell carcinomas in Taiwan." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/08422435463447834404.

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博士<br>長庚大學<br>生物醫學研究所<br>97<br>Promoter methylation is one of the mechanisms for gene silencing leading to cancer. To investigate the relationship between promoter methylation and tumor clinicopathological paramaters, risk factors and patient’s clinical outcome, the promoter of 12 tumor suppressor / DNA repair genes was evaluated in 482 oral squamous cell carcinomas (OSCCs), using bisulfite PCR- denature high performance liquid chromatography (DHPLC). Overall, OSCCs had at least one gene methylation (74.1%, 357/482). The frequency of promoter methylation detected in the p14ARF (13.3%, 64/4

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"DNA Methylation and Gene Expression Profiling for Parkinson’s Biomarker Discovery." Doctoral diss., 2019. http://hdl.handle.net/2286/R.I.53707.

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abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder, diagnosed late in the disease by a series of motor deficits that manifest over years or decades. It is characterized by degeneration of mid-brain dopaminergic neurons with a high prevalence of dementia associated with the spread of pathology to cortical regions. Patients exhibiting symptoms have already undergone significant neuronal loss without chance for recovery. Analysis of disease specific changes in gene expression directly from human patients can uncover invaluable clues about a still unknown etiology, the

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Tor, Moron Dalla. "GENOME-WIDE DNA METHYLATION PROFILING OF OBESE INSULIN RESISTANT CHILDREN." Doctoral thesis, 2021. http://hdl.handle.net/11562/1045548.

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Introduzione: L’insulino resistenza si presenta quando la risposta delle cellule all’insulina è diminuita causando un drammatico innalzamento dei livelli di zucchero nel sangue. I diversi fattori di rischio per l’insulino resistenza includono uno stile di vita sedentario, obesità, storia familiare di diabete e invecchiamento. Negli ultimi anni, il diabete di tipo 2, l’insulino resistenza e l’obesità sono considerevolmente aumentate nella popolazione contribuendo all’incremento in morbidità e mortalità nel mondo. I molti meccanismi proposti per spiegare il funzionamento dell’insulino resistenza

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Lin, Yu-Chih, and 林昱至. "Establishment of novel identification systems for biofluids by DNA methylation profiling." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/84107865609545858352.

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博士<br>國立中興大學<br>生物科技學研究所<br>105<br>The identification of a specific biofluid encountered in a forensic investigation can give crucial information. This identification can be aided by methylation profiles based on selected markers specific to a range of biofluids. In this study, the open database of Infinium HumanMethylation450 BeadChip was searched for markers specific for semen, vaginal fluids, saliva, venous blood and menstrual blood. Two systems based on analyzing methylation profile were developed. The first system utilizes methylation-specific PCR combined with single-base-extension (MSP-

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Pitamber, Punita Navnital. "Methylation profiling of paternally imprinted loci in male gametes following alcohol exposure." Thesis, 2012. http://hdl.handle.net/10539/15891.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Master of Science in Medicine<br>Fetal Alcohol Syndrome (F AS), the most severe form of Fetal Alcohol Spectrum Disorder (F ASD), has traditionally been associated with maternal alcohol consumption during pregnancy. However, a number of animal studies have shown an association between paternal preconception alcohol consumption and developmental abnormalities in the offspring that resemble the features of F AS. Dysregulation of epi

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19

Chiu, Kai-Tse, and 邱鎧澤. "Gene Methylation Profiling of Lung Cancer Cells using CpG Islands Microarray Analysis." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/62179895084783212404.

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碩士<br>國立中興大學<br>生命科學系所<br>95<br>The process of DNA methylation is a commom existed mechanism in life to modulate epigenetic express. Different degrees of methylation in chromosomes were identified. The phenomenon is explained to modulate the different physiological express by diversity methylation degrees in different kind of species. And each of them has their own dependent physiological express. However, the genetic modultated mechanisms of the methylation are not clearly understood. This study is to analysis the GpG sites of 56 paired non-small lung cancer specimens provided by Taichung Vet

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Costa, Ana Laura da Silva. "DNA Methylation Profiling as a Tool for Testicular Germ Cell Tumors Subtyping." Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/109407.

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Costa, Ana Laura da Silva. "DNA Methylation Profiling as a Tool for Testicular Germ Cell Tumors Subtyping." Dissertação, 2017. https://repositorio-aberto.up.pt/handle/10216/109407.

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22

Chang, Jer-Wei, and 張哲維. "Genome-Wide Methylation Profiling and Candidate Gene Methylation Spectrum in Lung Cancer: In Relation to Gene Expression and Clinical Significance." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/44973150880579843617.

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博士<br>國立臺灣師範大學<br>生命科學研究所<br>97<br>Cancer is caused by the accumulation of both genetic and epigenetic changes. Promoter hypermethylation is one of the major epigenetic changes that cause gene inactivation. Aberrant promoter hypermethylation of CpG islands associated with tumor suppressor genes (TSGs) can lead to transcriptional silencing and result in tumorigenesis. The genomic regions with hypermethylation status may possess novel candidate TSGs. The present study used a microarray-based epigenome-wide methylation analysis called differential methylation hybridization (DMH) to identify the r

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Chang, Chia-Wei, and 張家瑋. "An Integrative Model with CGI and Pathway Information for Differential DNA Methylation Profiling." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/52765979286812810319.

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碩士<br>國立臺灣大學<br>流行病學與預防醫學研究所<br>102<br>DNA methylation (DNAm) occurs at cytosines in CpG dinucleotides and alters gene expression, and hence it may lead to development of diseases. DNAm is an intermediate factor between genome sequence, environmental factors and gene expression; therefore, it could serve as a good choice of biomarker. Both CpG islands (CGI) and biological pathway might have effects on DNA methylation. However, among the methods for studying differential DNAm, to the best of our knowledge, no one has considered incorporating these two factors into analysis simultaneously. We pr

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Mercado, Augustus T., and 麥卡多. "DNA Methylation and miRNA Profiling of Neural Stem Cell Differentiation on Modified Silica Nanofibers." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/88729269921610552590.

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碩士<br>中原大學<br>生物科技研究所<br>101<br>A detailed collaboration of proteomic, genomic, and epigenomic analyses of neural stem cells (NSCs) in synthetic microenvironments will help us resolve some of the numerous questions in regards to regenerative medicine and therapeutic treatment of human diseases. Hence, to fully understand its properties, NSC differentiation on electrospun nanofibrous substrates and the effect on both their functional genetic and epigenetic profiles were analyzed. The objective of this study is to identify the changes in the epigenetic mechanisms involved in the NSC differentia

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Kaminsky, Zachary. "Development Of High Throughput Epigenomic Profiling Technologies And Their Application To Twin Based DNA Methylation Studies." Thesis, 2009. http://hdl.handle.net/1807/17779.

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Epigenetic studies hold the promise of addressing some of the fundamental questions of human biology including development, cell differentiation, and the aetiological mechanisms of complex disease. Over the last years, several new large scale high throughput technologies have been developed to allow genome wide profiling of epigenetic signals such as DNA methylation and histone modifications. Two of such technologies were developed in our laboratory enabling a genome wide microarray based profiling of DNA methylation signatures and a high throughput method for the site specific interrogation o

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Hsiao, Yi-Hsiu, and 蕭伊秀. "DNA methylation profiling in promoter regions of the cancer-associated gene in oral squamous cell carcinoma." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/54038091469182313563.

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碩士<br>中國醫藥大學<br>生物統計研究所<br>98<br>Background: Oral squamous cell carcinoma (OSCC) is the fourth most common cancer in men in Taiwan. DNA methylation plays an important role in cancer progression and development. DNA hypermethylation in promoter regions has been described as a mechanism of gene silencing. The aim of this study is to perform a genowide methylation profile of 1,505 CpG sites of 807 cancer-associated genes and search for a diagnosis and screening biomarker for OSCC. Study design: We conducted a case-control study to obtain tissue samples from the tissue bank of China Medical Univer

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Lin, Yi-Jiun, and 林怡君. "Profiling methylation status of tumor suppressor genes on chromosome 16 in human hepatocellular carcinoma in Taiwan." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/95054143224977745689.

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碩士<br>國立中興大學<br>生物醫學研究所<br>92<br>In Taiwan, hepatocellular carcinoma is the leading cause of cancer death. Hepatitis B virus and hepatitis C virus infections are the major contributing factors of hepatocarcinogenesis. Recent studies have reported that aberrant hypermethylation in the CpG-rich promoter regions of many tumor suppressor genes is associated with the lack of gene transcription and the development of hepatocellular carcinoma. Loss of heterozygosity on chromosome 16 is a common genetic alternation in human hepatocarcinomas, indicating the existence of tumor suppressor genes on this c

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Shames, David S. "Aberrant DNA Methylation and Cancer: A Global Analysis of Promoter Hypermethylation in Human Lung Cancers." 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=228.

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Skowronski, Karolina. "Profiling and Targeting Microenvironment-Induced Changes in the Cancer Epigenome." Thesis, 2012. http://hdl.handle.net/10214/3751.

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The tumor microenvironment consists of multiple cells types, including endothelial cells that line the tumor vasculature. Tumor vasculature is often abnormal and results in development of tissue ischemia, another contributing factor to the tumor microenvironment. Previous studies have demonstrated that ischemia influences epigenetic programming, but the mechanisms remained unclear and required further investigation. First, we profiled DNA methyltransferase (DNMT) expression and activity in human colorectal cancer cells (HCT116) under hypoxia or hypoglycaemia (mimicking ischemia). We found

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Yang, Wen-Ho, and 楊文和. "The DOP-PCR Specific for Genome-wide Amplification of Bisulfite-modified DNA and Analysis of Methylation Profiling." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/41644269874972347804.

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碩士<br>國立陽明大學<br>醫學生物技術研究所<br>95<br>Mammalian DNA methylation is an epigenetic process involving in transcriptional gene silencing, suppression of transposable elements and chromatin structure modulation. Aberrant methylation of CpG-rich promoter regions has been found in many human cancers. Methylation profiling also poses an important topic for study of embryonic stem cell and somatic cell cloning. The current method for methylation status analysis relies on bisulfite treatment of genomic DNA, followed by methylation-specific PCR (MSP). The difficulty for acquiring a methylation profiling is

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Erturk, Ece. "Photochemical and Enzymatic Method for DNA Methylation Profiling and Walking Approach for Increasing Read Length of DNA Sequencing by Synthesis." Thesis, 2018. https://doi.org/10.7916/D88W4WQ5.

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The first half of this dissertation demonstrates development of a novel method for DNA methylation profiling based on site specific conversion of cytosine in CpG sites catalyzed by DNA methyltransferases. DNA methylation, a chemical process by which DNA bases are modified by methyl groups, is one of the key epigenetic mechanisms used by cells to regulate gene expression. It predominantly occurs at the 5-position of cytosines in CpG sites and is essential in normal development. Aberrant methylation is associated with many diseases including cancer. Bisulfite Genomic Sequencing (BGS), the gold s

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Hao, Pengying. "The role of microRNAs, DNA methylation and translational control in regulation of sex specific gene expression in mouse liver." Thesis, 2018. https://hdl.handle.net/2144/31678.

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Sex differences are widespread in both mouse and human liver, and are associated with sex differences in drug metabolism and liver pathophysiology. The secretory patterns of growth hormone (GH) is one of the major drivers of liver sex specificity, where intermittent and continuous secretion in male and female respectively lead to sex bias in the expression of more than 1000 genes in mouse liver, via a complex interplay of GH-responsive transcription factors and epigenetic mechanisms. This thesis explores three themes of molecular control in the regulation of liver sex differences: microRNAs, D

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Shilpi, Arunima. "Profiling of DNA Methylation and Single Nucleotide Polymorphism for Diagnosis, Prognosis and Targeting DNA Methyltransferases for Therapeutic Intervention of Breast Cancer." Thesis, 2016. http://ethesis.nitrkl.ac.in/8209/1/2016_Phd_511LS102_Profiling.pdf.

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Breast cancer being multifaceted disease constitutes a wide spectrum of histological and molecular variability in tumors. Now, in the wake-up of the Human Genome Project (HGP) several evidences recommend a marked plasticity adopted by tumor cells in modulating the tissue invasion and progression during multiple stages of metastasis. However, the task for the identification of these casualties in a cancer genome is complicated by the interplay of inherited genetic and epigenetic aberrations. These aberrations are like two sides of the

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"Development of bioinformatics platforms for methylome and transcriptome data analysis." 2014. http://library.cuhk.edu.hk/record=b6115790.

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高通量大規模並行測序技術，又称為二代測序（NGS），極大的加速了生物和醫學研究的進程。隨著測序通量和複雜度的不斷提高，在分析大量的資料以挖掘其中的資訊的過程中，生物訊息學變得越發重要。在我的博士研究生期間（及本論文中），我主要從事於以下兩個領域的生物訊息學演算法的開發：DNA甲基化資料分析和基因間區長鏈非編碼蛋白RNA（lincRNA）的鑒定。目前二代測序技術在這兩個領域的研究中有著廣泛的應用，同時急需有效的資料處理方法來分析對應的資料。<br>DNA甲基化是一種重要的表觀遺傳修飾，主要用來調控基因的表達。目前，全基因組重亞硫酸鹽測序（BS-seq）是最準確的研究DNA甲基化的實驗方法之一，該技術的一大特點就是可以精確到單個堿基的解析度。為了分析BS-seq產生的大量測序數據，我參與開發並深度優化了Methy-Pipe軟體。Methy-Pipe集成了測序序列比對和甲基化程度分析，是一個一體化的DNA甲基化資料分析工具。另外，在Methy-Pipe的基礎上，我又開發了一個新的用於檢測DNA甲基化差異區域（DMR）的演算法，可以用於大範圍的尋找DNA甲基化標記。Methy-Pipe在我們實驗室的DNA甲基化研究項目中得到廣泛的應用，其中包括基於血漿的無創產前診斷（NIPD）和癌症的檢測。<br>基因間區長鏈非編碼蛋白RNA（lincRNA）是一種重要的調節子，其在很多生物學過程中發揮作

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Shapiro, Jonathan. "A Novel Approach to Identify Candidate Imprinted Genes in Humans." Thesis, 2012. http://hdl.handle.net/1807/32278.

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Many imprinted genes are necessary for normal human development. Approximately 70 imprinted genes have been identified in humans. I developed a novel approach to identify candidate imprinted genes in humans using the premise that imprinted genes are often associated with nearby parent-of-origin-specific DNA differentially methylated regions (DMRs). I identified parent-of-origin-specific DMRs using sodium bisulfite-based DNA (CpG) methylation profiling of uniparental tissues, mature cystic ovarian teratoma (MCT) and androgenetic complete hydatidiform mole (AnCHM), and biparental tissues, blood

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