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Journal articles on the topic 'Nachisu'

Author: Grafiati

Published: 26 February 2023

Last updated: 31 July 2025

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1

Pfahl, Dietmar. "An Interview with Nachiappan Nagappan - ACM Fellow 2020." ACM SIGSOFT Software Engineering Notes 46, no. 4 (2021): 14–15. http://dx.doi.org/10.1145/3485952.3485955.

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Nachiappan (Nachi) Nagappan is one of the five ACM Fellows of the 2020 cohort who are also active SIGSOFT members. To celebrate his award, we invited him to a question/answer session. Nachi earned his PhD from North Carolina State University (NCSU), USA, in 2005. Afterwards he was with Microsoft Research for more than 15 years, rising through the ranks from Software Engineer to Partner Researcher. In January 2021, he started in a new position with Facebook. Nachi's research interests are in the field of Software Engineering focusing on Software Reliability, Developer Productivity, Software Dat

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2

J, Nirmala Devi. "A Study of Verbal Phrase Theory in Mannan Chinnandi's Narratives." International Research Journal of Tamil 4, S-16 (2022): 92–103. http://dx.doi.org/10.34256/irjt224s1613.

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Mannan Chinnandi's father Mudharsonai was the ruler of a small area called Vellalur (Vellalur is a town in Maellur taluka of Madurai district). Eghuvaka Nachia was born in the region of Sirukudi. Mudharsonai and Eghuvakka Nachiya get married. Both of them have a daughter named Karala Purantha Karuthavanam and twins named Peperumal and Chinnandi. Eghuvakka Nachiya's brothers give her some land as dowry during her marriage. Mudharsonai goes to cultivate the land given to him by his brothers-in-law. But the wives of his brothers-in-law prevents him to enter the land. Mudharsonai is killed by his

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Zhu, Luke (Lei), Victoria L. Brescoll, George E. Newman, and Eric Luis Uhlmann. "Macho Nachos." Social Psychology 46, no. 4 (2015): 182–96. http://dx.doi.org/10.1027/1864-9335/a000226.

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Abstract. The present studies examine how culturally held stereotypes about gender (that women eat more healthfully than men) implicitly influence food preferences. In Study 1, priming masculinity led both male and female participants to prefer unhealthy foods, while priming femininity led both male and female participants to prefer healthy foods. Study 2 extended these effects to gendered food packaging. When the packaging and healthiness of the food were gender schema congruent (i.e., feminine packaging for a healthy food, masculine packaging for an unhealthy food) both male and female parti

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4

Reis, Shmuel, and Michael C. Klein. "Such naches." Patient Education and Counseling 83, no. 1 (2011): 45–46. http://dx.doi.org/10.1016/j.pec.2010.03.012.

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5

Bienstein, Christel. "Nachts im Krankenhaus." Heilberufe 67, no. 1 (2015): 66. http://dx.doi.org/10.1007/s00058-015-1259-0.

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6

Scrase, David, and Michael Krüger. "Nachts, unter Bäumen." World Literature Today 71, no. 1 (1997): 144. http://dx.doi.org/10.2307/40152647.

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7

Vilhena, Ian Brito, Larissa Baía de Nazaré, Carolina Silene Machado Monteiro, et al. "ELABORAÇÃO DE NACHOS SEMIPRONTOS COM PATO DESIDRATADO E FARINHA DE PUPUNHA LIOFILIZADA / ELABORATION OF SEMI-DRAWN NACHES WITH DEHYDRATED DUCK AND LYOPHILIZED PUPUNHA FLOUR." Brazilian Journal of Development 6, no. 9 (2020): 68212–22. http://dx.doi.org/10.34117/bjdv6n9-308.

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8

Henderson, Brandon J., Rahul Srinivasan, Weston A. Nichols, et al. "Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors." Journal of General Physiology 143, no. 1 (2013): 51–66. http://dx.doi.org/10.1085/jgp.201311102.

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Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson’s disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is known about the effect of chronic nicotine on these nAChRs. We report here that nicotine up-regulates α6* nAChRs in several mouse brain regions (substantia nigra pars compacta, ventral tegmental area, medial habenula, and superior colliculus)

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9

Zhao, Yue. "The Oncogenic Functions of Nicotinic Acetylcholine Receptors." Journal of Oncology 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/9650481.

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Nicotinic acetylcholine receptors (nAChRs) are ion channels that are expressed in the cell membrane of all mammalian cells, including cancer cells. Recent findings suggest that nAChRs not only mediate nicotine addiction in the brain but also contribute to the development and progression of cancers directly induced by nicotine and its derived carcinogenic nitrosamines whereas deregulation of the nAChRs is observed in many cancers, and genome-wide association studies (GWAS) indicate that SNPs nAChRs associate with risks of lung cancers and nicotine addiction. Emerging evidences suggest nAChRs ar

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Lingutla, Deerajnath, Mohammad Titi, Ankit Rohatgi, and Tarun Kothari. "NACHOS Induced Panesophageal Ulcers." American Journal of Gastroenterology 104 (October 2009): S387. http://dx.doi.org/10.14309/00000434-200910003-01054.

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11

Mohr, Friedrich-Wilhelm. "Neulich Nachts in Houston†." European Journal of Cardio-Thoracic Surgery 52, no. 3 (2017): 401–7. http://dx.doi.org/10.1093/ejcts/ezx251.

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12

Hain, Fabian. "Herz nachts unter Druck." Deutsche Heilpraktiker-Zeitschrift 14, no. 01 (2019): 44–49. http://dx.doi.org/10.1055/a-0829-0355.

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SummaryHerzrasen, Schweißausbrüche und Hypertonie. Diese Symptome lassen Patienten mit Schlafhypertonie mitten in der Nacht aus dem Schlaf hochschrecken. Die Ursache der Schlafhypertonie ist in der Regel eine diastolische Herzinsuffizienz verschiedener Genese, die einen erhöhten Innendruck zur Folge hat. Eine sinnvolle naturheilkundliche Therapieoption ist die Aderlasstherapie basierend auf der sogenannten Doppel-Hämatokrit-Analyse.

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13

Salzmann, Wiebke, and Roland Wengenmayr. "Eines Nachts am Nordpol." Physik in unserer Zeit 33, no. 1 (2002): 38. http://dx.doi.org/10.1002/1521-3943(200201)33:1<38::aid-piuz38>3.0.co;2-e.

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14

Friederich, Patrick, André Dybek, and Bernd W. Urban. "Stereospecific Interaction of Ketamine with Nicotinic Acetylcholine Receptors in Human Sympathetic Ganglion-like SH-SY5Y Cells." Anesthesiology 93, no. 3 (2000): 818–24. http://dx.doi.org/10.1097/00000542-200009000-00032.

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Background Surprising clinical evidence suggests a block of sympathetic transmission by ketamine. The action of ketamine on nicotinic acetylcholine receptors (nAChRs) in human ganglions is unknown. Because ganglionic transmission depends on nAChRs, such information may help to clarify whether ketamine impairs ganglionic transmission in men. Because racemic ketamine as well as S(+)-ketamine are used clinically, the authors investigated stereospecific effects on human ganglionic nAChRs. Stereospecific psychomimetic effects have been attributed to voltage-dependent Kv channel inhibition; therefor

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Eom, Sanung, Chaelin Kim, Hye Duck Yeom та ін. "Molecular Regulation of α3β4 Nicotinic Acetylcholine Receptors by Lupeol in Cardiovascular System". International Journal of Molecular Sciences 21, № 12 (2020): 4329. http://dx.doi.org/10.3390/ijms21124329.

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Cardiovascular disease (CVD) occurs globally and has a high mortality rate. The highest risk factor for developing CVD is high blood pressure. Currently, natural products are emerging for the treatment of hypertension to avoid the side effects of drugs. Among existing natural products, lupeol is known to be effective against hypertension in animal experiments. However, there exists no study regarding the molecular physiological evidence against the effects of lupeol. Consequently, we investigated the interaction of lupeol with α3β4 nicotinic acetylcholine receptors (nAChRs). In this study, we

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Tornøe, C., L. Holden-Dye, C. Garland, S. N. Abramson, J. T. Fleming, and D. B. Sattelle. "Lophotoxin-insensitive nematode nicotinic acetylcholine receptors." Journal of Experimental Biology 199, no. 10 (1996): 2161–68. http://dx.doi.org/10.1242/jeb.199.10.2161.

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Nematode nicotinic acetylcholine receptors (nAChRs) are molecular targets of several anthelmintic drugs. Studies to date on Caenorhabditis elegans and Ascaris suum have demonstrated atypical pharmacology with respect to nAChR antagonists, including the finding that kappa-bungarotoxin is a more effective antagonist than alpha-bungarotoxin on Ascaris muscle nAChRs. Lophotoxin and its naturally occurring analogue bipinnatin B block all vertebrate and invertebrate nAChRs so far examined. In the present study, the effects on nematode nAChRs of bipinnatin B have been examined. The Ascaris suum muscl

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17

Kozlov, Sergey. "The reasons and starting positions of the agrarian reforms by the beginning of the 1950s." OOO "Zhurnal "Voprosy Istorii" 2023, no. 12-3 (2023): 44–69. http://dx.doi.org/10.31166/voprosyistorii202312statyi58.

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The article deals with the issues of legal regulation of the agrarian policy of the Soviet state in the early 1950s. The author highlights the main administrative and legal methods of implementing the agrarian reforms.

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18

Peigneur, Steve, Prabha Devi, Andrea Seldeslachts, Samuthirapandian Ravichandran, Loïc Quinton та Jan Tytgat. "Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi". Marine Drugs 17, № 9 (2019): 535. http://dx.doi.org/10.3390/md17090535.

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The a-Conotoxins are peptide toxins that are found in the venom of marine cone snails and they are potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs). Because nAChRs have an important role in regulating transmitter release, cell excitability, and neuronal integration, nAChR dysfunctions have been implicated in a variety of severe pathologies. We describe the isolation and characterization of α-conotoxin MilIA, the first conopeptide from the venom of Conus milneedwardsi. The peptide was characterized by electrophysiological screening against several types of cl

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Pratik, Anant Thakar, and Nisha Wagh Prof. "Development of Nachos using Cucurbita (Pumpkin) Seed Powder, Sorghum (Jowar) Flour, Zea Mays (Maize) Flour, and Cicer Arietunum (Besan)." International Journal of Trend in Scientific Research and Development Journal 7, no. 1 (2023): 501–5. https://doi.org/10.5281/zenodo.7714950.

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The study of Nachos was carried out at the Department of Food Technology, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat. This research shows the health benefits of pumpkin seeds and the major goal was to develop Nachos that could be enjoyed by all age groups by using the same as Pumpkin seed have an Antimicrobial and Antioxidant property and are rich in protein content as well. Three formulations with control sample were formulated for the preparation of Nachos. Nachos was developed by using pumpkin seeds, which was first roasted and ground into powder and combined w

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REED, B. T., F. R. AMTHOR та K. T. KEYSER. "Rabbit retinal ganglion cell responses mediated by α-bungarotoxin-sensitive nicotinic acetylcholine receptors". Visual Neuroscience 19, № 4 (2002): 427–38. http://dx.doi.org/10.1017/s0952523802194053.

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The responses of many ganglion cells in the rabbit retina are mediated, at least in part, by acetylcholine (ACh) acting on neuronal nicotinic acetylcholine receptors (nAChRs). nAChRs are comprised of α and β subunits; three β subunits and nine α subunits of nAChRs have been identified and these subunits can combine to form a large number of functionally distinct nAChR subtypes. We examined the effects of cholinergic agents on the light-evoked responses of ganglion cells to determine which nAChR subtypes mediate the effects of ACh. Extracellular recordings of retinal ganglion cells were made in

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21

Peters, Lea. "Eigener Nachbau erfordert ein hohes Augenmerk." agrarzeitung 78, no. 32 (2023): 9. http://dx.doi.org/10.51202/1869-9707-2023-32-009-1.

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22

Hajiasgharzadeh, Khalil, Behzad Baradaran, Leili Aghebati Maleki, and Alireza Khabbazi. "Nicotinic Acetylcholine Receptors as Potential Tumor Biomarkers in Genitourinary Cancers: a Review Study." ImmunoAnalysis 1, no. 1 (2021): 4. http://dx.doi.org/10.34172/ia.2021.04.

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The genitourinary tissues express the different subtypes of nicotinic acetylcholine receptors (nAChRs), which are involved in many physiologic and pathologic processes. New studies have indicated the significant role of nAChRs in multiple tumor-related properties in different types of malignancies. Genitourinary cancers (GUCs) represent a heterogeneous population of cancers, in both histology and approach to treatment. nAChRs are functionally expressed by a variety of immune cells, tumor cells, and tumor-associated cells in the microenvironment of GUCs. In the current review study, publication

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Richards, David P., Rohit N. Patel, Ian R. Duce, et al. "(−)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors." Molecules 27, no. 20 (2022): 7074. http://dx.doi.org/10.3390/molecules27207074.

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Ladybird beetles (Coleoptera: Coccinellidae) possess strong chemical defences that are secreted in response to stress and are also found on the coating of eggs, which are rich in alkaloids that are responsible for their toxicity to other species. Recent studies have shown that alkaloids from several species of ladybird beetle can target nicotinic acetylcholine receptors (nAChRs) acting as receptor antagonists. Here, we have explored the actions of (−)-adaline, found in the 2-spot (Adalia bipunctata) and 10-spot (Adalia decempunctata) ladybirds, on both mammalian (α1β1γδ, α7, α4β2, α3β4) and in

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24

Yamaguchi, Hiroyuki, Herman Friedman, and Yoshimasa Yamamoto. "Involvement of Nicotinic Acetylcholine Receptors in Controlling Chlamydiapneumoniae Growth in Epithelial HEp-2 Cells." Infection and Immunity 71, no. 6 (2003): 3645–47. http://dx.doi.org/10.1128/iai.71.6.3645-3647.2003.

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ABSTRACT Nicotinic acetylcholine receptors (nAChRs) play an essential role in neurotransmission. Recent studies have indicated that nAChRs may be involved in the regulation of some bacterial infections through immunological mechanisms in macrophages. However, the regulation of infection with Chlamydia pneumoniae, which is a ubiquitous pneumonia-causing bacterium, by an nAChR-mediated mechanism is still unclear. In the present study, it was found that stimulation of nAChRs with ligands such as nicotine and acetylcholine altered the growth of C. pneumoniae in epithelial HEp-2 cells. Thus, the re

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Wu, Jin, Masatomo Ishikawa, Jichun Zhang, and Kenji Hashimoto. "Brain Imaging of Nicotinic Receptors in Alzheimer's Disease." International Journal of Alzheimer's Disease 2010 (2010): 1–11. http://dx.doi.org/10.4061/2010/548913.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels which are widely distributed in the human brain. Several lines of evidence suggest that two major subtypes (α4β2 and α7) of nAChRs play an important role in the pathophysiology of Alzheimer's disease (AD). Postmortem studies demonstrated alterations in the density of these subtypes of nAChRs in the brain of patients with AD. Currently, nAChRs are one of the most attractive therapeutic targets for AD. Therefore, several researchers have made an effort to develop novel radioligands that can be used to s

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Verma, Saurabh, Sudhanva Srinivas Kashyap, Alan Patrick Robertson, and Richard John Martin. "Functional genomics in Brugia malayi reveal diverse muscle nAChRs and differences between cholinergic anthelmintics." Proceedings of the National Academy of Sciences 114, no. 21 (2017): 5539–44. http://dx.doi.org/10.1073/pnas.1619820114.

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Many techniques for studying functional genomics of important target sites of anthelmintics have been restricted to Caenorhabditis elegans because they have failed when applied to animal parasites. To overcome these limitations, we have focused our research on the human nematode parasite Brugia malayi, which causes elephantiasis. Here, we combine single-cell PCR, whole muscle cell patch clamp, motility phenotyping (Worminator), and dsRNA for RNAi for functional genomic studies that have revealed, in vivo, four different muscle nAChRs (M-, L-, P-, and N-). The cholinergic anthelmintics had diff

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Hanganu, Ileana L., and Heiko J. Luhmann. "Functional Nicotinic Acetylcholine Receptors on Subplate Neurons in Neonatal Rat Somatosensory Cortex." Journal of Neurophysiology 92, no. 1 (2004): 189–98. http://dx.doi.org/10.1152/jn.00010.2004.

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The establishment of cortical synaptic circuits during early development requires the presence of subplate neurons (SPn's), a heterogeneous population of neurons capable to integrate and process synaptic information from the thalamus, cortical plate, and neighboring SPn's. An accumulation of cholinergic afferents and nicotinic acetylcholine receptors (nAChRs) has been documentated in the subplate around birth. To assess the developmental role of the cholinergic innervation onto SPn's, we used whole cell patch-clamp recordings of visually identified and biocytin-labeled SPn's in neonatal rat so

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Shelukhina, Irina, Andrei Siniavin, Igor Kasheverov, Lucy Ojomoko, Victor Tsetlin та Yuri Utkin. "α7- and α9-Containing Nicotinic Acetylcholine Receptors in the Functioning of Immune System and in Pain". International Journal of Molecular Sciences 24, № 7 (2023): 6524. http://dx.doi.org/10.3390/ijms24076524.

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Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the nervous and immune systems, muscles and on the cells of other organs. In the immune system, inflammation is regulated via the vagus nerve through the activation of the non-neuronal α7 nAChR subtype, affecting the production of cytokines. The analgesic properties of α7 nAChR-selective compounds are mostly based on the activation of the cholinergic anti-inflammatory pathway. The molecular mechanism of neuropathic pain relief mediated by the inhibition of α9-containing nAChRs is not fully understood yet, but the

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Harkins, Amy B., and Aaron P. Fox. "Activation of Nicotinic Acetylcholine Receptors Augments Calcium Channel-mediated Exocytosis in Rat Pheochromocytoma (PC12) Cells." Journal of General Physiology 111, no. 2 (1998): 257–69. http://dx.doi.org/10.1085/jgp.111.2.257.

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The functional effect of activating Ca2+-permeable neuronal nicotinic acetylcholine receptors (nAChRs) on vesicle secretion was studied in PC12 cells. Single cells were patch-clamped in the whole-cell configuration and stimulated with either brief pulses of nicotine to activate the Ca2+-permeable nAChRs or with voltage steps to activate voltage-dependent Ca2+ channels. Membrane capacitance was used as a measure of vesicle secretion. Activation of nAChRs by nicotine application to cells voltage clamped at −80 mV evoked secretion. This secretion was completely abolished by nicotinic antagonists.

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Koranda, Jessica L., Jackson J. Cone, Daniel S. McGehee, Mitchell F. Roitman, Jeff A. Beeler, and Xiaoxi Zhuang. "Nicotinic receptors regulate the dynamic range of dopamine release in vivo." Journal of Neurophysiology 111, no. 1 (2014): 103–11. http://dx.doi.org/10.1152/jn.00269.2013.

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Nicotinic acetylcholine receptors (nAChRs) are expressed presynaptically on dopamine axon terminals, and their activation by endogenous acetylcholine from striatal cholinergic interneurons enhances dopamine release both independently of and in concert with dopamine neuron activity. Acute nAChR inactivation is believed to enhance the contrast between low- and high-frequency dopamine cell activity. Although these studies reveal a key role for acute activation and inactivation of nAChRs in striatal microcircuitry, it remains unknown if chronic inactivation/desensitization of nAChRs can alter dopa

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Shan, Hongyu, Nan Wang, Xinyu Gao та ін. "Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain". Marine Drugs 22, № 5 (2024): 200. http://dx.doi.org/10.3390/md22050200.

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α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized, and is closely related to Alzheimer’s disease (AD), epilepsy, schizophrenia, lung cancer, Parkinson’s disease (PD), inflammation, and other diseases. α-conotoxins from marine cone snail venom are typically short, disulfide-rich neuropeptides targeting nAChRs and can distinguish various subtypes, providing vital pharmacological tools for the fu

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MANEU, VICTORIA, GUILLERMO GERONA, LAURA FERNÁNDEZ, NICOLÁS CUENCA, and PEDRO LAX. "Evidence of alpha 7 nicotinic acetylcholine receptor expression in retinal pigment epithelial cells." Visual Neuroscience 27, no. 5-6 (2010): 139–47. http://dx.doi.org/10.1017/s0952523810000246.

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AbstractSome evidence suggests that retinal pigment epithelium (RPE) can express nicotinic acetylcholine receptors (nAChRs) as described for other epithelial cells, where nAChRs have been involved in processes such as cell development, cell death, cell migration, and angiogenesis. This study is designed to determine the expression and activity of α7 nAChRs in RPE cells. Reverse transcriptase (RT)-PCR was performed to test the expression of nicotinic α7 subunit in bovine RPE cells. Protein expression was determined by Western blot and by immunocytochemistry. Expression of nicotinic α7 subunits

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Batool, Shadab, Basma Akhter, Jawwad Zaidi та ін. "Neuronal Menin Overexpression Rescues Learning and Memory Phenotype in CA1-Specific α7 nAChRs KD Mice". Cells 10, № 12 (2021): 3286. http://dx.doi.org/10.3390/cells10123286.

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The perturbation of nicotinic cholinergic receptors is thought to underlie many neurodegenerative and neuropsychiatric disorders, such as Alzheimer’s and schizophrenia. We previously identified that the tumor suppressor gene, MEN1, regulates both the expression and synaptic targeting of α7 nAChRs in the mouse hippocampal neurons in vitro. Here we sought to determine whether the α7 nAChRs gene expression reciprocally regulates the expression of menin, the protein encoded by the MEN1 gene, and if this interplay impacts learning and memory. We demonstrate here that α7 nAChRs knockdown (KD) both i

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Yang, Danqing, Robert Günter, Guanxiao Qi, Gabriele Radnikow, and Dirk Feldmeyer. "Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific." Cerebral Cortex 30, no. 6 (2019): 3528–42. http://dx.doi.org/10.1093/cercor/bhz324.

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Abstract Acetylcholine (ACh) is known to regulate cortical activity during different behavioral states, for example, wakefulness and attention. Here we show a differential expression of muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs) in different layer 6A (L6A) pyramidal cell (PC) types of somatosensory cortex. At low concentrations, ACh induced a persistent hyperpolarization in corticocortical (CC) but a depolarization in corticothalamic (CT) L6A PCs via M 4 and M1 mAChRs, respectively. At ~ 1 mM, ACh depolarized exclusively CT PCs via α4β2 subunit-containing nAChRs wit

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Lungidningtyas, Angganararas, and Arli Aditya Parikesit. "In Silico Analysis of Ethanol Binding Activity in Neuronal Nicotinic Acetylcholine Receptors." Malaysian Journal of Applied Sciences 5, no. 1 (2020): 54–61. http://dx.doi.org/10.37231/myjas.2020.5.1.243.

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Ethanol and nicotine are two common substances that are often linked to complications in alcoholic smokers. The high number of the co-consumptions in alcoholic smokers suggested a possible interaction between ethanol and nicotine in the central nervous system and a potential similar mechanism of action. Both ethanol and nicotine are shown to bind with neuronal nicotinic acetylcholine receptors (nAChRs), a ligand gated cation channel specifically targeted by the endogenous acetylcholine. Ethanol has a much less specific binding capability to modulate the receptors, however, emerging reports ind

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Panchal, Jayharsh L. "Dual Signaling Modes of Alpha7 Nicotinic Acetylcholine Receptors (α7 nAChRs)". Annals of Experimental and Molecular Biology 1, № 1 (2018): 1–2. http://dx.doi.org/10.23880/aemb-16000102.

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This themed section of the Annals of Experimental and Molecular Biology is the product of an article that is focusing on metabotropic signaling of an ionotropic channel alpha7 nicotinic ACh receptors (α7 nAChRs). The article talks about how α7 nAChR, being an ion channel, can function in a metabotropic-signaling mode via Gprotein coupling followed by Gαq-PLC-IP3-Ca2+ release

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Erhard, Daniela, and Peter Galle. "Todesfall nachts um halb zwei." Lege artis - Das Magazin zur ärztlichen Weiterbildung 3, no. 05 (2013): 330–33. http://dx.doi.org/10.1055/s-0033-1360837.

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Mo, Ye-Xiong, Ya-Fu Yin, and Ya-Ming Li. "Neural nAChRs PET imaging probes." Nuclear Medicine Communications 35, no. 2 (2014): 135–43. http://dx.doi.org/10.1097/mnm.0000000000000032.

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Heinemann, Markus. "Neulich Nachts in Houston—Again!" Thoracic and Cardiovascular Surgeon 65, S 03 (2017): S149. http://dx.doi.org/10.1055/s-0037-1600922.

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Tauber-Bachmann, Cornelia. "Und nachts kein Auge zugetan …" Deutsche Zeitschrift für Akupunktur 63, no. 4 (2020): 247–48. http://dx.doi.org/10.1007/s42212-020-00314-z.

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Weil, Joachim. "Wenn der Blutdruck nachts steigt…" CardioVasc 20, no. 6 (2020): 29–30. http://dx.doi.org/10.1007/s15027-020-3422-z.

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djb. "Was macht die COPD nachts?" Der Hausarzt 50, no. 9 (2013): 58. http://dx.doi.org/10.1007/s15200-013-0498-x.

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Gillissen, Adrian, and Brigitte Moreano. "Wenn nachts die Luftnot kommt …" Allergo Journal 20, no. 3 (2011): 140. http://dx.doi.org/10.1007/bf03362463.

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Harsch, Igor Alexander. "Womit sich Zuckerkranke nachts herumquälen." MMW - Fortschritte der Medizin 155, no. 5 (2013): 63–66. http://dx.doi.org/10.1007/s15006-013-0294-5.

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Fleischmann, Mathias. "Nachts sind alle Stifte rot." Pädagogik, no. 11 (November 11, 2019): 10–13. http://dx.doi.org/10.3262/paed1911010.

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Manche Dinge kann man nur mit Humor nehmen. Dahinter steckt aber oft ein reales Problem, in diesem Fall das Korrekturfach oder – schlimmer noch – die Korrekturfächer. Wie machen sich korrekturintensive Fächer im Alltag bemerkbar? Wie sieht die Welt beim und nach dem Korrigieren aus? Ein literarischer Erfahrungsbericht, der Ernstes in die Sprache des Humors verkleidet und dabei durchaus zum Nachdenken anregen will.

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Pilarski, Jason Q., Hilary E. Wakefield, Andrew J. Fuglevand, Richard B. Levine, and Ralph F. Fregosi. "Increased nicotinic receptor desensitization in hypoglossal motor neurons following chronic developmental nicotine exposure." Journal of Neurophysiology 107, no. 1 (2012): 257–64. http://dx.doi.org/10.1152/jn.00623.2011.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are expressed on hypoglossal motor neurons (XII MNs) that innervate muscles of the tongue. Activation of XII MN nAChRs evokes depolarizing currents, which are important for regulating the size and stiffness of the upper airway. Although data show that chronic developmental nicotine exposure (DNE) blunts cholinergic neurotransmission in the XII motor nucleus, it is unclear how nAChRs are involved. Therefore, XII MN nAChR desensitization and recovery were examined in tissues from DNE or control pups using a medullary slice preparation and tight

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Manasa, R., Mariyam Farooqui, M. Deepika, Sofia, R. Shekhara Naik, and Mahesh Shivananjappa. "Formulation of nutrient-rich nachos using little millet (Panicum sumatrense) Flour." Annals of Geriatric Education and Medical Sciences 10, no. 2 (2024): 51–54. http://dx.doi.org/10.18231/j.agems.2023.012.

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: Nachos, originating from northern Mexico, are traditionally made using maize flour and commonly served as appetizers or snacks. Little millet, a nutritious alternative to maize, boosts high levels of iron, phosphorous, and protein, making it gluten-free and suitable for those with celiac disease.: This research was conducted to develop a value-based product with a lower gluten and carbohydrate content than standard nachos. : The study involved preparation of Nachos by replacing a portion of wheat flour with Little Millet flour in various ratios. The sensory quality of the developed Nachos wa

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Tapper, Andrew R., Sheri L. McKinney, Michael J. Marks та Henry A. Lester. "Nicotine responses in hypersensitive and knockout α4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice". Physiological Genomics 31, № 3 (2007): 422–28. http://dx.doi.org/10.1152/physiolgenomics.00063.2007.

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Nicotinic receptors containing the α4 subunit (α4* nAChRs) have high sensitivity and are widely expressed in the central nervous system, yet their contributions to behavioral tolerance, a hallmark of nicotine dependence, are unclear. To evaluate the contribution of α4* and non-α4 nAChRs in the development of tolerance to hypothermia and locomotor suppression, α4 knockout (KO), hypersensitive Leu9′Ala α4 knock-in, and wild-type (WT) mice received daily nicotine injections, and their behaviors were compared. Repeated selective activation of α4* nAChRs in Leu9′Ala mice produced profound tolerance

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Romero, Haylie K., Sean B. Christensen, Lorenzo Di Cesare Mannelli та ін. "Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain". Proceedings of the National Academy of Sciences 114, № 10 (2017): E1825—E1832. http://dx.doi.org/10.1073/pnas.1621433114.

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Opioids are first-line drugs for moderate to severe acute pain and cancer pain. However, these medications are associated with severe side effects, and whether they are efficacious in treatment of chronic nonmalignant pain remains controversial. Medications that act through alternative molecular mechanisms are critically needed. Antagonists of α9α10 nicotinic acetylcholine receptors (nAChRs) have been proposed as an important nonopioid mechanism based on studies demonstrating prevention of neuropathology after trauma-induced nerve injury. However, the key α9α10 ligands characterized to date ar

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Violet, J. M., D. L. Downie, R. C. Nakisa, W. R. Lieb, and N. P. Franks. "Differential Sensitivities of Mammalian Neuronal and Muscle Nicotinic Acetylcholine Receptors to General Anesthetics." Anesthesiology 86, no. 4 (1997): 866–74. http://dx.doi.org/10.1097/00000542-199704000-00017.

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Background Nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of fast neurotransmitter-gated receptor channels that includes the gamma-aminobutyric acidA (GABAA), glycine and serotonin type 3 (5-HT3) receptors. Most previous work on the interactions of general anesthetics with nAChRs has involved the muscle-type receptor. The authors investigate the effects of general anesthetics on defined mammalian neuronal and muscle nAChRs expressed in Xenopus oocytes. Methods Complementary deoxyribonucleic acid (cDNA) or messenger ribonucleic acid (mRNA) encoding for various neuronal

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