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Journal articles on the topic "NAHS"

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Coitinho, Juliana, Debora Costa, Samuel Guimaraes, Cintia Neves, Simara Araujo, Mariana Costa, and Ronaldo Nagem. "Structural characterization of Polycyclic Aromatic Hydrocarbon degrading enzymes." Acta Crystallographica Section A Foundations and Advances 70, a1 (August 5, 2014): C472. http://dx.doi.org/10.1107/s2053273314095278.

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Polycyclic aromatic hydrocarbons (PAHs) are a group of aromatic hydrocarbons composed of two or more fused rings and include naphthalene, phenanthrene, pyrene and benzo[a]pyrene amongst others. Exposure to naphthalene has been associated with several toxic manifestations in humans and laboratory animals, with the lens of the eye and the lungs being most sensitive [1]. Additionally, this compound has been reclassified as a possible human carcinogen by the US Environmental Protection Agency and the International Agency for Research on Cancer. It has recently been suggested that naphthalene undergoes metabolic activation to 1,2-naphthoquinone, which reacts with DNA, leading to the formation of apurinic sites on DNA and depurinating DNA adducts [2]. Moreover, a number of studies have attested to the carcinogenic and mutagenic properties of more complex PAHs, suggesting the need for further work on the elimination of these compounds from the environment. The Gram-negative bacterium P. putida G7 is among the best studied naphthalene-degrading species. The genes associated with naphthalene metabolism are localized on NAH7, an 83 kilobase plasmid. In P. putida G7 the naphthalene-oxidation genes are organized into two operons under salicylate control. The first operon (upper naphthalene-degradation pathway) includes the genes nahAaAbAcAdBCDEF, which code for the conversion of naphthalene to salicylate, while the second operon (lower pathway) includes the genes nahGTHINLOMKJ responsible for the oxidation of salicylate via the catechol meta-cleavage pathway [3]. In the last years, our group focused on the structure elucidation and the kinetic characterization of the P. putida G7 enzymes involved in the naphthalene degradation pathway. We intend to present these results which basically describe the 3D structures of NahB, NahF, NahG, NahI, NahK and NahK/NahL complex and some kinetic data of these enzymes and their mutants. This work was supported by FAPEMIG, CNPq and VALE S.A.
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Jupiter, Ryan C., Daniel Yoo, Edward A. Pankey, Vishwaradh V. G. Reddy, Justin A. Edward, David J. Polhemus, Taylor C. Peak, Prasad Katakam, and Philip J. Kadowitz. "Analysis of erectile responses to H2S donors in the anesthetized rat." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 5 (September 2015): H835—H843. http://dx.doi.org/10.1152/ajpheart.00293.2015.

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Hydrogen sulfide (H2S) is a biologically active endogenous gasotransmitter formed in penile tissue that has been shown to relax isolated cavernosal smooth muscle. In the present study, erectile responses to the H2S donors sodium sulfide (Na2S) and sodium hydrosulfide (NaHS) were investigated in the anesthetized rat. Intracavernosal injections of Na2S in doses of 0.03–1 mg/kg increased intracavernosal pressure and transiently decreased mean arterial pressure in a dose-dependent manner. Blood pressure responses to Na2S were rapid in onset and short in duration. Responses to Na2S and NaHS were similar at doses up to 0.3 mg/kg, after which a plateau in the erectile response to NaHS was reached. Increases in intracavernosal pressure in response to Na2S were attenuated by tetraethylammonium (K+ channel inhibitor) and iberiotoxin (large-conductance Ca2+-activated K+ channel inhibitor), whereas glybenclamide [ATP-sensitive K+ (KATP) channel inhibitor] and inhibitors of nitric oxide (NO) synthase, cyclooxygenase, and cytochrome P-450 epoxygenase had no effect. These data indicate that erectile responses to Na2S are mediated by a tetraethylammonium- and iberiotoxin-sensitive mechanism and that KATP channels, NO, or arachidonic acid metabolites are not involved. Na2S did not alter erectile responses to sodium nitroprusside (NO donor) or cavernosal nerve stimulation, indicating that neither NO nor cGMP metabolism are altered. Thus, Na2S has erectile activity mediated by large-conductance Ca2+-activated K+ channels. It is suggested that strategies that increase H2S formation in penile tissue may be useful in the treatment of erectile dysfunction when NO bioavailability, KATP channel function, or poor responses to PGE1 are present.
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NAKATA, Masataka, Masato OSAWA, Naotatsu SHIKAZONO, Hisahide HONMA, and Noriko TSUKAMOTO. "Corrosion of Au-Ag Alloys in NaHS and Na2S Solutions." Journal of the Surface Finishing Society of Japan 45, no. 1 (1994): 98–102. http://dx.doi.org/10.4139/sfj.45.98.

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Reátegui-Romero, Warren, Fredy Castillejo-Melgarejo, and María E. King-Santos. "Industrial Manufacturing of Aqueous Solutions of Sodium Sulfhydrate (NaHS 43%) in a Multi-Phase Reactor." Open Chemical Engineering Journal 13, no. 1 (May 31, 2019): 46–67. http://dx.doi.org/10.2174/1874123101913010046.

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Background: This research deals with the manufacture of sodium sulphides and sodium sulfhydrate in an isothermal multiphase chemical reactor to produce concentrated aqueous solutions of sodium sulfhydrate (greater than 43%) through Gas-Liquid-Solid reactions from hydrogen sulfide and hydroxide of sodium at 50%. Methods: A method is proposed that integrates the recovery of hydrogen sulfide from an industrial chemical process where the H2S gas is generated as a sub product, the strategy of the developed process was integrated into a manufacturing plant of dithiophosphoric acids (ADTF) where it was possible to recover the hydrogen sulfide in the form of an aqueous solution of NaHS with a concentration higher than 43%. Results: The experimental tests showed that the biphasic reaction mixture formed by Na2S, NaHS and H2O with global compositions of 13.3%; 26.9% and 59.7% respectively, is appropriate to obtain 43% sodium sulfhydrate in a stirred tank reactor, operated at temperatures ranging from 50°C to 55°C, where gaseous hydrogen sulfide is continually bubbled. Conclusion: Sodium sulfide (specifically Na2S.5H2O crystals) of the biphasic mixture is produced from a solution of sodium sulfhydrate (43% NaHS) and aqueous sodium hydroxide (50% NaOH). The environmental problem generated by the H2S was solved with a 90% recovery in the multiphase reactor and 5% in the safety absorber.
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Matsuoka, Hidekazu, Kohei Mitsuhashi, Masanobu Kawata, and Chiharu Tokoro. "Derivation of Flotation Kinetic Model for Activated and Depressed Copper Sulfide Minerals." Minerals 10, no. 11 (November 18, 2020): 1027. http://dx.doi.org/10.3390/min10111027.

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The wettability and floatability of oxidized chalcocite, bornite, and chalcopyrite with the conditions of sodium hydrosulfide (NaHS) dosages and pHs were studied by contact angle measurements, and single and mixture mineral flotation tests. To evaluate the results of the flotation, the flotation kinetic model for copper sulfide minerals treated by NaHS was derived. In this study, we focused on the activation and depression by NaHS, a well-known activator and depressant of copper minerals. The flotation results showed that there can be a threshold NaHS dosage to activate the mineral surfaces, as evidenced by the depression of the minerals and reduction of recoveries at higher dosages of NaHS. Chalcocite recoveries increased with an increase of NaHS dosage. Bornite recoveries tended to be depressed with a smaller amount of NaHS as pH increased. The recoveries of chalcopyrite increased as pH increased at an optimum NaHS dosage. Moreover, the flotation kinetic model that includes the surface properties and the reaction rate constant between the copper sulfide minerals and NaHS was derived. The trends of the flotation rate constants and mass fractions with NaHS dosages and pHs could quantitatively well-explain the flotation results.
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Zhao, Lanfu, Yuan Wang, Quan Yan, Wenhai Lv, Yufu Zhang, and Shiming He. "Exogenous hydrogen sulfide exhibits anti-cancer effects though p38 MAPK signaling pathway in C6 glioma cells." Biological Chemistry 396, no. 11 (November 1, 2015): 1247–53. http://dx.doi.org/10.1515/hsz-2015-0148.

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Abstract It has been documented that H2S, in some types of cancer, promotes tumor proliferation, whereas, in the other types, it inhibits the tumor cell growth. In the present study, we investigated the anti-cancer effects and relevant mechanisms of NaHS in C6 glioma cells. C6 cells were subjected to different concentrations of NaHS, then cell viability and morphological changes were examined by MTT assay and Hoechst staining. The protein expression of Caspase-3, Bcl-2, Bax, p38 MAPK (mitogen-activated protein kinase), and p53 was measured by Western blotting. This work demonstrated that NaHS could reduce cell number and induce apoptosis of C6 gliomas cells. The protein expression of Caspase-3 and Bax was up-regulated, while the protein expression of Bcl-2 was down-regulated. Additionally, p38 MAPK and p53 were activated in response to NaHS. Moreover, p38 MAPK inhibitor, SB203580, counteracted the inhibitory effect of NaHS on C6 glioma cells. These data suggest that NaHS can effectively reduce cell number of C6 cells by triggering the apoptosis via Caspase-dependent pathway. p38 MAPK and p53 play an important role in NaHS-induced apoptosis in C6 cells. These findings imply that administration of NaHS may represent a new strategy for the treatment of glioma.
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Yu, Qian, Zhihong Lu, Lei Tao, Lu Yang, Yu Guo, Yonghui Yang, Xude Sun, and Qian Ding. "ROS-Dependent Neuroprotective Effects of NaHS in Ischemia Brain Injury Involves the PARP/AIF Pathway." Cellular Physiology and Biochemistry 36, no. 4 (2015): 1539–51. http://dx.doi.org/10.1159/000430317.

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Background/Aims: Stroke is among the top causes of death worldwide. Neuroprotective agents are thus considered as potentially powerful treatment of stroke. Methods: Using both HT22 cells and male Sprague-Dawley rats as in vitro and in vivo models, we investigated the effect of NaHS, an exogenous donor of H2S, on the focal cerebral ischemia-reperfusion (I/R) induced brain injury. Results: Administration of NaHS significantly decreased the brain infarcted area as compared to the I/R group in a dose-dependent manner. Mechanistic studies demonstrated that NaHS-treated rats displayed significant reduction of malondialdehyde content, and strikingly increased activity of superoxide dismutases and glutathione peroxidase in the brain tissues compared with I/R group. The enhanced antioxidant capacity as well as restored mitochondrial function are NaHS-treatment correlated with decreased cellular reactive oxygen species level and compromised apoptosis in vitro or in vivo in the presence of NaHS compared with control. Further analysis revealed that the inhibition of PARP-1 cleavage and AIF translocation are involved in the neuroprotective effects of NaHS. Conclusion: Collectively, our results suggest that NaHS has potent protective effects against the brain injury induced by I/R. NaHS is possibly effective through inhibition of oxidative stress and apoptosis.
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Ke, Xiao, Jun Zou, Qingsong Hu, Xiaoqing Wang, Chengheng Hu, Rongfeng Yang, Jiawen Liang, Xiaorong Shu, Ruqiong Nie, and Changnong Peng. "Hydrogen Sulfide-Preconditioning of Human Endothelial Progenitor Cells Transplantation Improves Re-Endothelialization in Nude Mice with Carotid Artery Injury." Cellular Physiology and Biochemistry 43, no. 1 (2017): 308–19. http://dx.doi.org/10.1159/000480411.

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Background/Aims: The aim of present study was to test the hypothesis that preconditioning with sodium hydrosulfide (NaHS) could enhance the capacity of migration, adhesion and proliferation of endothelial progenitor cells (EPCs) in vitro, and also could improve the efficacy of EPCs transplantation for re-endothelialization in nude mice with carotid artery injury. The paper further addressed the underlying mechanisms. Methods: EPCs were isolated from peripheral blood mononuclear cells of healthy male volunteers and the markers of EPCs were analyzed by flow cytometry. Thereafter, different concentrations of NaHS (25, 50, 100, 200 and 500 uM) were used for preconditioning EPCs. In vitro and in vivo migration, adhesion and proliferation as well as nitric oxide (NO) production of EPCs were evaluated. Carotid artery injury model was produced in nude mice and thereafter, NaHS-preconditioned EPCs were transplanted in order to evaluate their capacity of re-endothelialization. Results: Cellular immuno-staining showed that isolated cells expressed the key markers of EPCs. In vitro, EPCs proliferation rates and NO production were gradually increased in a NaHS-concentration dependent manner, while these benefits were blocked at a concentration of 500 uM NaHS. Similarly, the migration and adhesion rates of EPCs were also increased the most prominently at a concentration of 200 µM NaHS. In vivo, compared to the control group, treatment with NaHS-preconditioned EPCs significantly enhanced the capacity of re-endothelialization of EPCs. Fluorescent microscope revealed that there were more EPCs homing to the injury vessels in the NaHS-preconditioned EPCs group than the non-preconditioned group. With the administration of AMPK or eNOS inhibitors respectively, the above benefits of NaHS-preconditioning were abrogated. Conclusion: These results suggested that NaHS-preconditioning enhanced the biological function and re-endothelialization of EPCs through the AMPK/eNOS signaling pathway.
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Zuidema, Mozow Y., Kelly J. Peyton, William P. Fay, William Durante, and Ronald J. Korthuis. "Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of heme oxygenase-1." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 3 (September 2011): H888—H894. http://dx.doi.org/10.1152/ajpheart.00432.2010.

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We recently demonstrated that preconditioning with an exogenous hydrogen sulfide donor (NaHS-PC) 24 h before ischemia and reperfusion (I/R) causes postcapillary venules to shift to an anti-inflammatory phenotype in C57BL/6J wild-type (WT) mice such that these vessels fail to support increases in postischemic leukocyte rolling (LR) and leukocyte adhesion (LA). The objective of the present study was to determine whether heme oxygenase-1 (HO-1) is a mediator of these anti-inflammatory effects noted during I/R in mice preconditioned with NaHS. Intravital fluorescence microscopy was used to visualize LR and LA in single postcapillary venules of the murine small intestine. I/R induced marked increases in LR and LA, effects that were prevented by NaHS-PC. Treatment with the HO inhibitor tin protoporphyrin IX, but not the inactive protoporphyrin CuPPIX, just before reperfusion prevented the anti-inflammatory effects of antecedent NaHS. The anti-inflammatory effects of NaHS-PC were mimicked by preconditioning with hemin, an agent that induces HO-1 expression. We then evaluated the effect of NaHS as a preconditioning stimulus in mice that were genetically deficient in HO-1 (HO-1−/−on an H129 background with appropriate WT strain controls). NaHS-PC was ineffective in HO-1−/−mice. Our work indicates that HO-1 serves as an effector of the anti-inflammatory effects of NaHS-PC during I/R 24 h later.
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Possomato-Vieira, José Sérgio, Victor Hugo Gonçalves-Rizzi, Regina Aparecida do Nascimento, Rodrigo Roldão Wandekin, Mayara Caldeira-Dias, Jessica Sabbatine Chimini, Maria Luiza Santos da Silva, and Carlos A. Dias-Junior. "Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension." BioMed Research International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/4627391.

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Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H2S) have been reported previously. However, no studies examined involvement of H2S in Pb-induced hypertension. We found increases in diastolic blood pressure and mean blood pressure in Pb-intoxicated humans followed by diminished H2S plasmatic levels. In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, and Pb + NaHS. Pb-intoxicated animals received intraperitoneally (i.p.) 1st dose of 8 μg/100 g of Pb acetate and subsequent doses of 0.1 μg/100 g for seven days and sodium hydrosulfide- (NaHS-) treated animals received i.p. NaHS injections (50 μmol/kg/twice daily) for seven days. NaHS treatment blunted increases in systolic blood pressure, increased H2S plasmatic levels, and diminished whole-blood lead levels. Treatment with NaHS in Pb-induced hypertension seems to induce a protective role in rat aorta which is dependent on endothelium and seems to promote non-NO-mediated relaxation. Pb-intoxication increased oxidative stress in rats, while treatment with NaHS blunted increases in plasmatic MDA levels and increased antioxidant status of plasma. Therefore, H2S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension.
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Dissertations / Theses on the topic "NAHS"

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Helmy, Nada. "Etude des mécanismes du développement de la stéatohépatite non alcoolique (NAHS) chez des patients obèses." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC261.

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'L'obésité est actuellement un des enjeux majeurs de santé publique au niveau mondial et national. La NAFLD (non-alcoholic fatty liver disease) représente une des complications majeures associées à l'obesité et est considérée comme la manifestation hépatique du syndrome métabolique. Le terme NAFLD regroupe l'ensemble des lésions hépatiques évoluant de la stéatose isolée (réversible) vers l'hépatite stéatosique (NASH) ayant un potentiel de progression vers la fibrose, la cirrhose et éventuellement le carcinome hépatocellulaire. A l'heure actuelle, les mécanismes responsables de l'instauration chez le patient obèse d'une NAFLD, et surtout d'une NASH, ne sont pas élucidés. L'objectif de ma thèse était de déterminer chez des patients obèses si des altérations hépatiques du métabolisme lipidique et/ou de la fonction mitochondriale, dans un contexte de surcharge lipidique du foie, peuvent participer à l'évolution de la NAFLD. Des biopsies hépatiques chirurgicales peropératoires ont été obtenues de patients obèses morbides opérés d'une chirurgie bariatrique, ainsi que de témoins non obèses. Les flux métaboliques d'acide gras à chaîne longue (AGCL) réalisés à l'aide de l'oléate [1-¹⁴C] et l'exploration de la respiration mitochondriale ont été réalisés sur du tissu frais. Les résultats montrent une altération de la β-oxydation mitochondriale complète des AGCL chez les patients obèses ayant une NASH (réduction de ¹⁴c—CO₂, augmentation des ¹⁴ccorps acido-solubles, et baisse de la cétogenèse hépatique). La production de CO₂ (oxydation complète des AGCL) est corrélée négativement avec les contenus hépatiques en triglycérides et diacylglycérols, qui sont augmentés chez les patients obèses NASH par rapport aux autres groupes. La respiration mitochondriale a été mesurée par oxygraphie en présence de différents substrats et inhibiteurs mitochondriaux sur l'homogénat de foie ainsi que sur des mitochondries isolées. Une réduction générale de la respiration a été observée entre les sujets témoins et tous les groupes de patients obèses. Cependant, la NASH est associée à une diminution significative de la respiration mitochondriale par rapport aux autres patients obèses. Ces altérations ne sont pas associées à une modification de la masse mitochondriale, ni à une altération de l'expression protéique des complexes OXPHOS de la chaîne respiratoire
Obesity is currently one of the major public health issues worldwide and nationally. NAFLD (non-alcoholic fatty liver disease) represents one of the major complications associated with obesity, and is considered as the hepatic manifestation of metabolic syndrome. The term NAFLD extends from simple steatosis (reversible) to steatohepatitis (NASH) having potential progression to fibrosis, cirrhosis and possibly hepatocellular carcinoma. At present, the mechanisms responsible for the establishment of NAFLD in obese patients, and its evolution towards NASH, are not well understood. The aim of my thesis was to determine if alterations in liver lipid metabolism and/or mitochondrial function, in a context of fat overload of the liver, could participate in the development of NASH. Intraoperative surgical liver biopsies were obtained from morbidly obese patients undergoing bariatric surgery, as well as non-obese controls. The long-chain fatty acid (LCFA) metabolic fluxes using [1-¹⁴C]oleate and exploration of mitochondrial respiration were performed on fresh liver tissue. The results show impaired complete LCFA oxidation in obese NASH patients (decreased ¹⁴cCO₂increased ¹⁴c acido-soluble products, decreased ketogenesis). Hepatic ¹⁴cCO₂ production negatively correlates with liver triglyceride and diacylglycerol contents, which are increased in obese NASH patients compared to other groups. Mitochondrial respiration was measured by oxygraphy using different substrates and inhibitors in liver homogenate as well as isolated mitochondria. A general reduction in mitochondrial respiration was observed between control group and all obese patients groups. However, NASH is associated with a significant decreased mitochondrial respiratiorewhen compared to other obese patients. These alterations are not associated with a change in mitochondrial mass, nor in protein expression of respiratory OXPHOS complexes
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Castillo, Letícia Nunes Carreras Del. "Tradução, adaptação cultural e validação do Nonarthritic Hip Score para o Brasil." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4771.

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Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro
A avaliação da qualidade de vida tem sido cada vez mais utilizada pelos profissionais da área de saúde para mensurar o impacto de doenças na vida dos pacientes, bem como para avaliar os resultados dos tratamentos realizados. O crescente interesse por protocolos de pesquisa clínica em doenças não degenerativas do quadril tem encontrado muitos obstáculos na avaliação objetiva de seus resultados, principalmente nos estudos de observação de novas intervenções terapêuticas, como a artroscopia. O Nonarthritic Hip Score (NAHS) é um instrumento de avaliação clínica, desenvolvido originalmente em inglês, cujo objetivo é avaliar a função da articulação do quadril em pacientes jovens e fisicamente ativos. O objetivo desse estudo foi traduzir esse instrumento para a língua portuguesa, adaptá-lo para a cultura brasileira e validá-lo para que possa ser utilizado na avaliação de qualidade de vida de pacientes brasileiros com dor no quadril, sem doença degenerativa. A metodologia utilizada é a sugerida por Guillemin et al. (1993) e revisado por Beaton et al. (2000), que propuseram um conjunto de instruções padronizadas para adaptação cultural de instrumentos de qualidade de vida, incluindo cinco etapas: tradução, tradução de volta, revisão pelo comitê, pré-teste e teste, com reavaliação dos pesos dos escores, se relevante. A versão de consenso foi aplicada em 30 indivíduos. As questões sobre atividades esportivas e tarefas domésticas foram modificadas, para melhor adaptação à cultura brasileira. A versão brasileira do Nonarthritic Hip Score (NAHS-Brasil) foi respondida por 64 pacientes com dor no quadril, a fim de avaliar as propriedades de medida do instrumento: reprodutibilidade, consistência interna e validade. A reprodutibilidade foi 0,9, mostrando uma forte correlação; a consistência interna mostrou correlação entre 0,8 e 0,9, considerada boa e excelente; a validade foi considerada respectivamente boa e excelente; a correlação entre NAHS-Brasil e WOMAC foi 0,9; e a correlação entre o NAHS-Brasil e Questionário Algofuncional de Lequesne foi 0,79. O Nonarthritic Hip Score foi traduzido para a língua portuguesa e adaptado à cultura brasileira, de acordo com o conjunto de instruções padronizadas para adaptação cultural de instrumentos de qualidade de vida. Sua reprodutibilidade, consistência interna e validade foram também demonstradas.
The assessment of quality of life has been increasingly used by health professionals to measure the consequences of disease on patients' lives and evaluate the results of treatments. The growing interest in clinical research protocols of non-arthritic hip diseases has found many difficulties in dealing with the objective assessment of its results, especially in observational studies of new therapeutic interventions such as arthroscopy. The Nonarthritic Hip Score (NAHS) is a clinical assessment tool, originally developed in English to evaluate the function of the hip joint in young and physically active patients. The aim of this study was to translate this instrument into Portuguese, adapt it to the Brazilian culture and validate it, in order to evaluate quality of life of Brazilian patients with hip pain without osteoarthritis. The methodology used is suggested by Guillemin et al., (1993) and reviewed by Beaton et al., (2000), who proposed a set of standardized instructions for cultural adaptation of instruments for quality of life, including five steps: translation, back translation, review by committee, pre-test and test with a reassessment of the weights of scores, if relevant. The consensus version was administered to 30 individuals. Questions about sports and household chores were modified to better adapt to the Brazilian culture. The Brazilian version of Nonarthritic Hip Score (NAHS-Brasil) was answered by 64 patients with hip pain to evaluate the measurement properties of the instrument: reproducibility, internal consistency and validity. Reproducibility was 0.9, showing a strong correlation; the internal consistency showed a correlation between 0,8 and 0,9, considered good and excellent; the validity was considered good and excellent respectively; the correlation between NAHS-Brasil and WOMAC was 0,9, and the correlation between NAHS-Brasil and Lequesne Algofunctional Index was 0.79. The Nonarthritic Hip Score was translated into Portuguese and adapted to Brazilian culture, according to the instruction set of standardized instruments for cultural adaptation of quality of life. Its reliability, internal consistency and validity have also been demonstrated.
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Nash, Steven Donald. "What makes a transformational education leader?: an investigation into the antecedent experiences of K-12 transformational leadership." Diss., Montana State University, 2012. http://etd.lib.montana.edu/etd/2012/nash/NashS0512.pdf.

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Scant research exists investigating the relationship between antecedent life experiences and the development of transformational leadership behaviors. The purpose of this research was to investigate the relationship between education leaders' life experiences and their effectiveness as transformational leaders. To guide this study, two research questions were formulated: (1) Does a relationship exist between perceived transformational leadership skills and the lifespan factors of K-12 principals? (2) Which lifespan factors investigated for this study have the most influence on perceived transformational leadership skills?
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Nash, Ronald James. "Sleeping with the Enemy: Integrating Big-Box Retail with Existing Communities." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/nash/NashR0507.pdf.

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The intent of my thesis is to find a way to integrate a large big-box retailer into a community in such a way that it benefits the community as a whole. This must be accomplished within the parameters that mark the store as a viable option for the parent company as well. This ideal must be approached from the philosophy that box stores are a large part of the current American way of life and to let them grow unchecked will signal the inevitable death of downtown retail districts as more and more business gets sucked to the super-stores and the areas immediately surrounding them. To do this we will need to find what benefits a box-store can add to a community and further research and rethink the typically negative aspects of these retail giants to find a way to incorporate them into our downtown shopping districts, without destroying their original feel. With this thesis, it is my intent to create a viable model that allows box stores to act as anchors and catalysts for a downtown area (either existing or built) rather than its death knell. To do this I will be rethinking a number of design strategies with the seamless integration of community and big-box retail in mind. To this end, I will not be acting to simply find a way to add a box-store and its typical trappings to the end of historic downtown street, but rather to find away to integrate a set of large box stores into a downtown community in such a way that benefits the citizens of that community on every designable level. I will be challenging not only the typical design strategies of a box store, but those of a typical downtown community as well. Seven major design strategies will be looked at during this project, they are: 1. Design for a diversity of use and users 2. Design a safe and secure streetscape that will encourage use. 3. Design a streetscape that accommodates pedestrians as equals with vehicle traffic. 4. Design a destination, not just a path. 5. Design it well. 6. Balance supply with demand. 7. Use aesthetics as an integration tool. With these design strategies, a box store can become an integral part of a downtown community ... or at least a much better alternative to the rampant sprawl that occurs with their current implementation strategy.
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Magazowski, Christoph [Verfasser], and Irene [Akademischer Betreuer] Peters. "Neuartige Tarifsysteme (NATS) für neuartige Sanitärsysteme (NASS) / Christoph Magazowski ; Betreuer: Irene Peters." Hamburg : HafenCity Universität Hamburg, 2017. http://d-nb.info/1140487256/34.

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Zanelato, Augusto Izuka [UNESP]. "Variedade riemannianas e imersão do tipo Nash: um ensaio e aplicações." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/94203.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
O presente trabalho tem por objetivo abordar aspectos fundamentais da teoria de imersão proposta por John Nash em 1954, na qual foi mostrado que uma variedade continua com derivada continuação nua C1, pode ser imersa em espaços euclidianos de 2n dimensões. Faz-se importante citar que ao longo do trabalho serão destacados aspectos inovadores do Teorema de Nash, tais como a não necessidade da hipótese de analitici-dade conforme havia sido usada anteriormente por Janet-Cartan, além do aspecto da perturbação que permite construir qualquer outra variedade imersa por uma sequência de deformações infinitesimais. São discutidos também extensões do Teorema de Nash, sobretudo os trabalhos de Greene e de Gunther, e aplicações do método perturbativo de Nash nas Teorias unificadoras da física.
The present work has for objective to approach basic aspects of the immersion theory proposal for John Nash in 1954, in which it was shown that a continuous variety with continuous derivative C1, can be immersed in Euclidean spaces of 2n dimensions. One becomes important to cite that throughout the work innovative aspects of the The- orem of Nash will be detached, such as the necessity of the hypothesis of in agreement analiticidade had not been used previously for Janet-Cartan, beyond the aspect of the disturbance that allows to construct any another immersed variety for a sequência of infinitesimal deformations. Extensions of the Theorem of Nash are also argued, over all the works of Greene and Gunther, and applications of the perturbativo method of Nash in the unifying Theories of the physics.
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Guimarães, Samuel Leite. "Clonagem, expressão e purificação das enzimas NahE e NahK de Pseudomonas putida para determinação de suas estruturas cristalográficas." Universidade Federal de Minas Gerais, 2011. http://hdl.handle.net/1843/BUOS-962K2C.

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Many pollutants are released to the environment due the use of petroleum and its derivatives. Some of them are classified as Polycyclic Aromatic Hydrocarbons (PAHs). Most of PAHs, or their metabolites, can interact with nitrogenous bases or cause lesions in DNA, potentiating mutations and consequently inducing the development of cancer. As a result of this, in the last decades, the concerns about contamination of soil and groundwater by PAHs have substantially increased. Various microorganisms have the capacity to use these hazardous molecules as carbon and energy source. The use of these microorganisms and/or their enzymes for the elimination of PAHs to the environment is a potential strategy for bioremediation. One of the most common and hazardous PAH is naphthalene, and because of the bacteria Pseudomonas putida ability to completely degrade it, it has been the focus of numerous studies. This work was focused in the study of two enzymes from P. putida involved in naphthalene degradation: NahE (a hydratase-aldolase) and NahK (a decarboxylase). The main objectives of this work were the amplification and cloning of nahE and nahK genes, expression and purification of NahE and NahK enzymes for biochemical and structural assays. The genes were initially cloned into the expression vector pET28a-TEV and expressed in Escherichia coli. The recombinant protein NahE was mainly detected in insoluble fraction and different trials were performed to obtain the protein in the soluble fraction, without success. Soluble NahE was obtained only when using denaturizing conditions of purification followed by a refolding protocol. On the other hand, NahK was detected in the soluble fraction and was purified by affinity and size-exclusion chromatographies. The purified proteins were submitted to Dynamic Light Scattering and Circular Dichroism experiments. Crystallization assays were also performed with NahK aiming crystal growth for elucidation of its three-dimensional structure by X-Ray Crystallography.
Devido ao uso do petróleo e seus derivados, diversos tipos de poluentes são liberados no meio ambiente. Alguns deles são classificados como Hidrocarbonetos Aromáticos Policíclicos (HAPs). A maioria dos HAPs, ou seus metabólitos, são capazes de interagir com bases nitrogenadas causando lesões no DNA, potencializando mutações e, consequentemente, o desenvolvimento de câncer. Como resultado disso, houve nas últimas décadas um aumento substancial na atenção dada às contaminações de solos e lençóis freáticos por HAPs. Inúmeros microrganismos possuem a capacidade de utilizar essas moléculas tóxicas como fontes de carbono e energia. O uso de determinadas bactérias (ou de suas enzimas) através de técnicas de biorremediação é uma estratégia em potencial para eliminação dos HAPs do ambiente. O HAP mais comum e tóxico é o naftaleno, e graças à capacidade da bactéria Pseudomonas putida em degradá-lo completamente, ela tem sido o foco de inúmeras pesquisas. Neste trabalho foram estudadas duas enzimas de P. putida envolvidas na degradação de naftaleno: NahE (uma hidratase-aldolase) e NahK (uma decarboxilase). O objetivo principal do trabalho foi a amplificação e clonagem dos genes nahE e nahK, expressão e purificação das respectivas enzimas para ensaios bioquímicos e estruturais. Os genes foram clonados inicialmente no vetor de expressão pET28a-TEV e expressos em Escherichia coli. A proteína recombinante NahE foi detectada em fração insolúvel e diversas estratégias foram utilizadas, sem sucesso, para obtenção da proteína expressa em fração solúvel. NahE solúvel foi obtida utilizando purificação em condições desnaturantes seguida por reenovelamento. Por outro lado, a proteína recombinante NahK foi detectada em fração solúvel e purificada por cromatografias de afinidade e de exclusão molecular. As proteínas purificadas foram submetidas a ensaios de Espalhamento Dinâmico de Luz e Dicroísmo Circular. Também foram realizados ensaios de cristalização com NahK visando o crescimento de cristais para a elucidação de sua estrutura tridimensional por cristalografia de Raios-X.
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Posluszny, Patricia. "Thomas Nashe's "Summer's last will and testament" : a critical modern-spelling edition /." New York ; Berne ; Frankfurt am Main : P. Lang, 1989. http://catalogue.bnf.fr/ark:/12148/cb35487402w.

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Nilsson, Erik, and Victor Pregén. "Performance evaluation of message-oriented middleware." Thesis, KTH, Hälsoinformatik och logistik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-283539.

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Message-oriented middleware (MOM) is a middleware used for communication between applications. There are many different MOM technologies available today, each offering different performance (throughput and latency). The performance of MOMs depends on both message size and message guarantee settings used. The problem is that it can be difficult for users to know which MOM they should choose given their requirements. The goal was to create a performance (latency and throughput) comparison of three popular MOMs; Apache Kafka, RabbitMQ and Nats Streaming. The result shows that Kafka is the best performing MOM for smaller message sizes (under 512 bytes). RabbitMQ has the best performance for larger message sizes (over 32768 bytes). Nats Streaming only outperformed the other message system for a few combinations of message guarantee settings with the message size 4096 bytes.
Meddelandeorienterad mellanprogramvara (MOM) är mellanprogramvara som används för kommunikation mellan applikationer. Det finns många MOM system som erbjuder olika prestanda (genomströmning och latens). Prestandan är beroende av vilka meddelandegarantier som används samt meddelande storlek. Detta gör det svårt för användare att välja MOM utifrån sina krav. Målet är därför att jämföra tre populära MOMs; Apache Kafka, RabbitMQ och Nats Streaming. Resultaten visar att Kafka presterar bäst med små meddelandestorlekar (Under 512 bytes). RabbitMQ presterar bäst för större meddelanden (Över 32768 bytes) medans Nats Streaming enbart presterar bäst med ett begränsat antal meddelandegarantier och med en meddelandestorlek på 4096 bytes.
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Lausberg, Sunia. "Neue Kenntnisse zur saarpfälzischen Rotliegendflora unter besonderer Berücksichtigung der Coniferentaxonomie und des Hinterlandes /." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967419905.

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Books on the topic "NAHS"

1

Marquez, Gabriel Garcia. Fi saat nahs. Beirut: Al Kitab Al Arabi, 2003.

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Marquez, Gabriel Garcia. Fi sa'at nahs. Amman: al-Muassassa al-Arabiya, 2003.

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Nayak, Harish. Dar nahi rad nahi. Ahmedabad: Vasundhara, 1988.

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Kaṃsārā, Maneśacandra. Kyāṃya nahi, kadī nahi--. Amadāvāda: Gujarātī Sāhitya Parishad, 1999.

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Crownover, Jay. Nash. London: Harper, 2014.

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Clarke, Brenda. Nars. London: Franklin Watts, 1985.

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Sayyid, Abū Zayd Ibrāhīm. Nahj Nahj al-Burdah: Shʻir. [Dubai: s.n., 1990.

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ʻAbbās, Nawfal Balsam Fāḍil, ed. Nahr Ṣaddām--: Al-nahr al-muʻjizah. Baghdād: Dār al-Shuʼūn al-Thaqāfīyah al-ʻĀmmah "Āfāq ʻArabīyah", 2001.

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Nash manifolds. Berlin: Springer-Verlag, 1987.

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Aṣdāʼ nafs. al-Qāhirah: Waʻd lil-Nashr wa-al-Tawzīʻ, 2011.

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Book chapters on the topic "NAHS"

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Holze, Rudolf. "Ionic conductance of NaHS." In Electrochemistry, 1531. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_1368.

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Ruiz, Maria C., Felipe Daroch, and Rafael Padilla. "Arsenic and Antimony Removal from Copper Concentrates by Digestion with Nahs-Naoh." In EPD Congress 2015, 1–12. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119093503.ch1.

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Ruiz, Maria C., Felipe Daroch, and Rafael Padilla. "Arsenic and Antimony Removal from Copper Concentrates by Digestion with NaHS-NaOH." In EPD Congress 2015, 5–12. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-48214-9_1.

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Froehlich, Stephan J., Carlo A. Lackerbauer, Guenter Rudolph, Jan Rémi, Soheyl Noachtar, Werner J. Heppt, Annette Cryer, et al. "NASH." In Encyclopedia of Molecular Mechanisms of Disease, 1434–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_6453.

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Dastagir, Golam. "Nafs." In Islam, Judaism, and Zoroastrianism, 519–22. Dordrecht: Springer Netherlands, 2018. http://dx.doi.org/10.1007/978-94-024-1267-3_2012.

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Froehlich, Stephan J., Carlo A. Lackerbauer, Guenter Rudolph, Jan Rémi, Soheyl Noachtar, Werner J. Heppt, Annette Cryer, et al. "NAGS." In Encyclopedia of Molecular Mechanisms of Disease, 1429. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8808.

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Collet, Christine. "Naos." In Active Rules in Database Systems, 279–96. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4419-8656-6_15.

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Bartocci, Claudio, Ugo Bruzzo, and Daniel Hernández Ruipérez. "Nahm transforms." In Fourier¿Mukai and Nahm Transforms in Geometry and Mathematical Physics, 147–82. Boston: Birkhäuser Boston, 2009. http://dx.doi.org/10.1007/b11801_5.

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Shikhman, Vladimir. "Nash-Gleichgewicht." In Mathematik für Wirtschaftswissenschaftler, 315–20. Wiesbaden: Springer Fachmedien Wiesbaden, 2019. http://dx.doi.org/10.1007/978-3-658-24543-6_47.

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Taylor, Joseph. "Nash Equilibrium." In Encyclopedia of Animal Cognition and Behavior, 1–4. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-47829-6_1341-1.

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Conference papers on the topic "NAHS"

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Werner, R., and H. Schöpe. "P1.5 Kostengünstige Nass/Nass-Differenzdruckmessung." In 20. GMA/ITG-Fachtagung Sensoren und Messsysteme 2019. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, 2019. http://dx.doi.org/10.5162/sensoren2019/p1.5.

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Lamqaddam, Houda, Jan Aerts, Koenraad Brosens, and Katrien Verbert. "NAHR." In NordiCHI'18: Nordic Conference on Human-Computer Interaction. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3240167.3240199.

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Godfrey, P. Brighten, and David Ratajczak. "Naps." In the third international symposium. New York, New York, USA: ACM Press, 2004. http://dx.doi.org/10.1145/984622.984686.

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"NAS enterprise architecture/NAS segment implementation plan (NAS EA/NSIP)." In 2015 Integrated Communication, Navigation and Surveillance Conference (ICNS). IEEE, 2015. http://dx.doi.org/10.1109/icnsurv.2015.7121358.

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Halpern, Joseph Y. "Beyond nash equilibrium." In the twenty-seventh ACM symposium. New York, New York, USA: ACM Press, 2008. http://dx.doi.org/10.1145/1400751.1400752.

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Gottlob, Georg, Gianluigi Greco, and Francesco Scarcello. "Pure Nash equilibria." In the 9th conference. New York, New York, USA: ACM Press, 2003. http://dx.doi.org/10.1145/846241.846269.

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Halpern, Joseph Y. "Beyond Nash equilibrium." In the Behavioral and Quantitative Game Theory. New York, New York, USA: ACM Press, 2010. http://dx.doi.org/10.1145/1807406.1807475.

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Wakim, Amy, Patrick Zabawa, Amanda Neukirch, and Nicholas P. Bigelow. "Luminorefrigeration of NaCs." In Laser Science. Washington, D.C.: OSA, 2010. http://dx.doi.org/10.1364/ls.2010.ltuh3.

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Nemcova, Jana, and Mihaly Petreczky. "Local Nash Realizations." In 2013 18th International Conference on Methods & Models in Automation & Robotics (MMAR). IEEE, 2013. http://dx.doi.org/10.1109/mmar.2013.6669919.

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Collet, C., and T. Coupaye. "The NAOS system." In the 1995 ACM SIGMOD international conference. New York, New York, USA: ACM Press, 1995. http://dx.doi.org/10.1145/223784.223887.

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Reports on the topic "NAHS"

1

Bagwell, Kyle, Robert Staiger, and Ali Yurukoglu. "Nash-in-Nash" Tariff Bargaining with and without MFN. Cambridge, MA: National Bureau of Economic Research, October 2017. http://dx.doi.org/10.3386/w23894.

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Collard-Wexler, Allan, Gautam Gowrisankaran, and Robin Lee. “Nash-in-Nash” Bargaining: A Microfoundation for Applied Work. Cambridge, MA: National Bureau of Economic Research, October 2014. http://dx.doi.org/10.3386/w20641.

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Alioğulları, Zeynel Harun, and Mehmet Barlo. Entropic selection of Nash equilibrium. Sabancı University, February 2012. http://dx.doi.org/10.5900/su_fass_wp.2012.18910.

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Evenchick, C. A., P. S. Mustard, C. J. Greig, M. E. McMechan, D H Ritcey, G. T. Smith, and F. Ferri. Geology, Nass River, British Columbia. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2008. http://dx.doi.org/10.4095/225792.

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Allman, M., S. Ostermann, and C. Metz. FTP Extensions for IPv6 and NATs. RFC Editor, September 1998. http://dx.doi.org/10.17487/rfc2428.

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Chatterjee, Krishnendu, Marcin Jurdzinski, and Rupak Majumdar. On Nash Equilibria in Stochastic Games. Fort Belvoir, VA: Defense Technical Information Center, October 2003. http://dx.doi.org/10.21236/ada603326.

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Bailey, David H. The NAS Parallel Benchmarks. Office of Scientific and Technical Information (OSTI), November 2009. http://dx.doi.org/10.2172/983318.

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Grau, P., V. Heinau, H. Schlichting, and R. Schuettler. Netnews Administration System (NAS). RFC Editor, October 2006. http://dx.doi.org/10.17487/rfc4707.

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Pan, Yaodong, Tankut Acarman, and Umit Ozguner. Nash Solution by Extremum Seeking Control Approach. Fort Belvoir, VA: Defense Technical Information Center, December 2002. http://dx.doi.org/10.21236/ada409514.

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Goldring, P. Geographical nams of Auyuittuq National Park Reserve. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1985. http://dx.doi.org/10.4095/298173.

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