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Journal articles on the topic 'Nail drug delivery'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Gaddime, Sonali B. Nagoba Shivappa N.* Suryawanshi S. R. Vijayendra Swamy S. M. "REVIEW ON TRANSUNGUAL: A NOVEL DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 918–25. https://doi.org/10.5281/zenodo.2538345.

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<em>The nail disorders are mainly due to fungal infection. When the drug is given through oral or systemic route, the potency of drugs gets decreased at the site of action. To avoid this loss of drug potency topical route of administration is used. This review is mainly about transungual drug delivery which means transfer of drug across the keratinized nails to treat nail fungal diseases and increasing bioavailability of various drugs used for nail diseases. Nail diseases are mainly caused by fungal infections; fungi are most responsible for nail diseases. So treatment of such infections is no

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Jeremiah, M. Christi* Chintan Aundhia Avinash Seth Nirmal Shah Dip Kondhia Snehal Patel. "REVIEW ON TRANSUNGUAL DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 686–706. https://doi.org/10.5281/zenodo.1036583.

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Topical therapy is highly desirable in treating nail disorders due to its localized effects, which results in minimal adverse systemic events and possibly improved adherence. The absorption of drugs into the nail unit, to the nail plate, is highly desirable to treat nail disorders; however, the effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Nail permeability is however quite low and limits topical therapy to early/mild disease states such as onychomycosis (fungal infections of the nail). Current research on nail permeation that focuses on alt

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Nair, Anroop B., Bandar E. Al-Dhubiab, Jigar Shah, et al. "Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design and In Vitro Evaluation." Pharmaceutics 13, no. 10 (2021): 1692. http://dx.doi.org/10.3390/pharmaceutics13101692.

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Topical therapy of antifungals is primarily restricted due to the low innate transport of drugs through the thick multi-layered keratinized nail plate. The objective of this investigation was to develop a gel formulation, and to optimize and evaluate the transungual delivery of terbinafine using the constant voltage iontophoresis technique. Statistical analysis was performed using Box–Behnken design to optimize the transungual delivery of terbinafine by examining crucial variables namely concentration of polyethylene glycol, voltage, and duration of application (2–6 h). Optimization data in ba

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Shikha, Rashmi, Dheeraj Bisht, Manoj Bhardwaj, and Manoj Bisht. "Formulation and Evaluation of Terbinafine HCL loaded Nanoparticles for Transungual delivery of drug in Fungal infection." Journal of Neonatal Surgery 14, no. 28S (2025): 383–402. https://doi.org/10.63682/jns.v14i28s.6615.

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In this review we mainly concern about the transungual delivery of drug to treat nail infection which is caused by the infection of a fungus. Transungual drug delivery is regarded as a very desirable treatment for various diseases in nail treatment due to its localized effects, which promote adherence while causing less unfavorable systemic effects. The nail is one of the toughest portions of the human body, and the nail plate presents a challenging barrier for drugs moiety to pass through . Topical medication delivery treatment is useful for treating numerous nail problems since it has locali

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Bharti, Lohani *and Ganesh Kumar. "MEDICATED NAIL LACQUERS – FOR EFFECTIVE TREATMENT OF NAIL DISORDERS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1392–403. https://doi.org/10.5281/zenodo.1197498.

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Transungual drug delivery system is related with the drug delivery over the nail, which is hard because of presence of keratin network into the nail. So in this review mainly concentrated on drug delivery over nail by using nail lacquer formulations, which containing drug on it .The drug delivery via nail plate is done due to association of several diseases into nail, for e.g. onychomycosis, psoriasis, paronychia, onycholysis .These nail diseases are occurred due to presence of several microorganisms like- several fungi, bacteria, parasites and to cure these diseases of nail, several medicatio

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Lalit Sharma, Navneet Mehan, Ritika Chouhan, et al. "Current review on nail drug delivery system and their future perspectives." World Journal of Biology Pharmacy and Health Sciences 19, no. 1 (2024): 337–49. http://dx.doi.org/10.30574/wjbphs.2024.19.1.0444.

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Human nails are not only beautiful and protective, but they may also be utilized as a vehicle for drug delivery, particularly in the treatment of nail disorders such as psoriasis and onychomycosis. Even though nails develop at a somewhat moderate rate, their highly keratinized structure presents unique opportunities and challenges for medication penetration. Achieving therapeutic doses might be difficult even with topical pharmaceutical delivery, which offers advantages like non-invasiveness and customized effect. Many physical and chemical methods, such as acid etching and permeation enhancer

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Lalit, Sharma, Mehan Navneet, Chouhan Ritika, et al. "Current review on nail drug delivery system and their future perspectives." World Journal of Biology Pharmacy and Health Sciences 19, no. 1 (2024): 337–49. https://doi.org/10.5281/zenodo.13789840.

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Human nails are not only beautiful and protective, but they may also be utilized as a vehicle for drug delivery, particularly in the treatment of nail disorders such as psoriasis and onychomycosis. Even though nails develop at a somewhat moderate rate, their highly keratinized structure presents unique opportunities and challenges for medication penetration. Achieving therapeutic doses might be difficult even with topical pharmaceutical delivery, which offers advantages like non-invasiveness and customized effect. Many physical and chemical methods, such as acid etching and permeation enhancer

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8

Kreutz, Tainá, Sheila Porto de Matos, and Letícia Scherer Koester. "Recent Patents on Permeation Enhancers for Drug Delivery Through Nails." Recent Patents on Drug Delivery & Formulation 13, no. 3 (2020): 203–18. http://dx.doi.org/10.2174/1872211313666191030155837.

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: The human nail is a unique barrier with a keratinized constitution that favors protection and fine touch. However, many disorders can affect the nail, among them, are the onychomycosis and psoriasis. Systemic oral therapy has been applied to treat these diseases, even presenting disadvantages, including side effects, drug interactions, contraindications, toxicity, high cost and low patient compliance. A great option to succeed in dealing with the problems associated with oral therapy is the topical administration of drugs. However, nail composition, low diffusion through ungual route and red

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9

Cordoba Díaz, Damian, Marta Losa Iglesias, Ricardo Becerro de Bengoa Vallejo, and Manuel Cordoba Diaz. "Transungual Delivery of Ciclopirox Is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an In Vitro Model." Pharmaceutics 11, no. 1 (2019): 29. http://dx.doi.org/10.3390/pharmaceutics11010029.

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Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. In this work, an in vitro model of the transungual delivery of antifungal agents is presented, which utilizes real nail tissue and an inline flow s

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Belikov A. V., Fyodorova Y. V., Kozlova A. D., and Smirnov S. N. "Laser delivery and spectral study of a modern chlorine-containing drug for the treatment of onychomycosis at laser radiation with a wavelength of 450 nm." Optics and Spectroscopy 130, no. 6 (2022): 688. http://dx.doi.org/10.21883/eos.2022.06.54705.37-22.

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The possibility of active laser delivery of a modern chlorine-containing photosensitizing drug Chloderm (Chloderm, Russia) under the nail plate by laser radiation with a wavelength of 450 nm for the purpose of photodynamic therapy of onychomycosis is studied. In an in vitro experiment, sequential laser microporation of the nail plate and active delivery of the drug under the nail plate by this laser radiation with an intensity of up to 200 W/cm2 were investigated. The results of studying the absorption spectra of an aqueous solution of Chloderm in the range of 400-900 nm before and after expos

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11

Abadi, Danielle, and Vesna Zderic. "Ultrasound-Mediated Nail Drug Delivery System." Journal of Ultrasound in Medicine 30, no. 12 (2011): 1723–30. http://dx.doi.org/10.7863/jum.2011.30.12.1723.

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12

R Popat, Ritesh, Apeksha R Rathi, Vaibhav S Adhao, and Vinayak N Shrikhande. "Nail drug delivery system a review." International Journal of Pharmaceutical Chemistry and Analysis 7, no. 1 (2020): 9–21. http://dx.doi.org/10.18231/j.ijpca.2020.002.

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13

Delgado-Charro, Maria Begoña. "Iontophoretic drug delivery across the nail." Expert Opinion on Drug Delivery 9, no. 1 (2011): 91–103. http://dx.doi.org/10.1517/17425247.2012.642364.

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14

Narasimha Murthy, S., Dora E. Wiskirchen, and Christopher Paul Bowers. "Iontophoretic Drug Delivery across Human Nail." Journal of Pharmaceutical Sciences 96, no. 2 (2007): 305–11. http://dx.doi.org/10.1002/jps.20757.

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15

Chouhan, Pradeep, та T. R. Saini. "Hydroxypropyl-β-cyclodextrin: A Novel Transungual Permeation Enhancer for Development of Topical Drug Delivery System for Onychomycosis". Journal of Drug Delivery 2014 (6 серпня 2014): 1–7. http://dx.doi.org/10.1155/2014/950358.

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The treatment of onychomycosis is a challenging task because of unique barrier properties of the nail plate which hampers the passage of antifungal drugs in a concentration required to eradicate the deeply seated causative fungi in the nail bed. In present investigation, application of hydroxypropyl-β-cyclodextrin (HP-β-CD) was established as an effective and nail friendly transungual drug permeation enhancer especially for poorly water soluble drugs using terbinafine hydrochloride as a poorly soluble drug. HP-β-CD significantly improves hydration of nail plates and increases solubility of ter

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16

Kishishita, Juliana, Camila de Almeida Perez Pimenta, Danielle Patricia Cerqueira Macedo, M. Begoña Delgado-Charro, and Leila Bastos Leal. "New Formulation–Microporation Combination Approaches to Delivering Ciclopirox across Human Nails." Pharmaceutics 16, no. 1 (2024): 72. http://dx.doi.org/10.3390/pharmaceutics16010072.

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Topical treatments for onychomycosis are of interest to those seeking to avoid systemic drug interactions and to improve systemic safety. This work aimed to develop aqueous-based, simple, and cost-effective vehicles that provide high solubility for ciclopirox and enable the delivery of an active through channels created by nail microporation. Following solubility tests, aqueous gels and thermogels based on hydroxypropylmethylcellulose and poloxamer 407, respectively, were loaded with 8% and 16% ciclopirox. Their performance was then compared to the marketed lacquer Micolamina® in in vitro rele

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17

Singh, Preeti. "Enhanced Medicated Lacquer Formulation for Managing Psoriatic Nail Disease." International Journal of Medical Science And Diagnosis Research 9, no. 1 (2025): 6–18. https://doi.org/10.32553/ijmsdr.v9i1.1050.

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Nail psoriasis often requires prolonged treatment, with frequent relapses being common. Effective management typically involves extended therapy, as oral anti-psoriatic medications can pose a risk of liver toxicity as a notable side effect. Alternative treatments include monthly corticosteroid injections into the nail folds. Topical therapies, such as medicated nail lacquers, offer the advantage of targeted drug delivery directly to the affected area, reducing systemic exposure and minimizing potential adverse effects. However, a significant challenge is achieving effective drug penetration th

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18

Nikhath, Misbah, and Sanjana S. "Formulation and Evaluation of Nail Drug Delivery System of Anti Fungal Drug." Asian Journal of Pharmaceutical Research and Development 10, no. 6 (2022): 44–52. http://dx.doi.org/10.22270/ajprd.v10i6.1189.

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The purpose of this study was to prepare nail lacquer for nail drug delivery system of anti fungal drug in order to improve the physicochemical parameters that influence the drug permeation through a nail plate to reach the systemic circulation and the neighbouring target sites. The success of local topical therapy for onychomycosis depends on the achievement of effective chemical concentrations into/through the human nail plate; therefore, a suitable antifungal drug must be coupled with an appropriate delivery method. The method should maximize the effect of the active principle by aiding its

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19

Беликов, А. В., Ю. В. Федорова, А. Д. Козлова та С. Н. Смирнов. "Лазерная доставка и спектральное исследование современного хлоринсодержащего препарата для лечения онихомикоза при лазерном воздействии с длиной волны 450 nm". Оптика и спектроскопия 130, № 6 (2022): 872. http://dx.doi.org/10.21883/os.2022.06.52629.37-22.

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The possibility of active laser delivery of a modern chlorine-containing photosensitizing drug “Chloderm” (Chloderm, Russia) under the nail plate by laser radiation with a wavelength of 450 nm for the purpose of photodynamic therapy of onychomycosis is studied. In an in vitro experiment, sequential laser microporation of the nail plate and active delivery of the drug under the nail plate by this laser radiation with an intensity of up to 200 W/cm2 were investigated. The results of studying the absorption spectra of an aqueous solution of Chloderm in the range of 400–900 nm before and after exp

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20

BHATTACHARJEE, BEDANTA, NIKITA DEY, DHUNUSMITA BARMAN, ARKA KARMAKAR, and NASIMA AHMED. "Understanding the drug delivery through nails: a comprehensive review." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 116–31. http://dx.doi.org/10.22270/jddt.v11i4.4941.

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The nail unit is the largest cutaneous musculo-skeletal appendage. The management of nail disorders is an onerous task owing to the disease manifestations and anatomical structure of the nail plate. The topical treatment of nail infections/disorders has been a centerpiece of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. However, transungual delivery had its challenges. This necessitated a lookout for novel approaches that enhanced treatment efficacy and reduced treatment time. Moreover, curing the nail condition using topi

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21

Chatur, V., S. Dhole, and N. Kulkarni. "Antifungal Niosomal Nail Lacquer for Enhanced Transungual Delivery of Efinaconazole in the Treatment of Onychomycosis." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 895–901. http://dx.doi.org/10.25258/ijddt.14.2.43.

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Niosomes, multilamellar vesicles, efficiently transfer active substances into the epidermis or systemic circulation. Topical medication delivery techniques increase skin permeability to active compounds. Onychomycosis, a common nail ailment caused by fungus, requires efficient topical therapies due to the risks of systemic antifungal therapy. This research aimed to make a nail polish with efinaconazole (EFN) to treat onychomycosis. The spherical Niosomes contained efinaconazole and had a 100 to 130 nm diameter. In the 24-hour in-vitro experiment, drug trapping ranged from 40 to 90% and release

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Valdes, Barbara, Ana Serro, Joana Marto, et al. "Polyurethanes as New Excipients in Nail Therapeutics." Pharmaceutics 10, no. 4 (2018): 276. http://dx.doi.org/10.3390/pharmaceutics10040276.

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Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity of oral drugs. Currently, the most common topical formulations (creams and lotions) present a low drug delivery to the nail infection. Nail lacquers appear to increase drug delivery and simultaneously improve the effectiveness of treatment with increased patient compliance. These formulations leave a polymer film on the na

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Cutrín-Gómez, Elena, Soledad Anguiano-Igea, M. Delgado-Charro, José Gómez-Amoza, and Francisco Otero-Espinar. "Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers." Pharmaceutics 10, no. 4 (2018): 273. http://dx.doi.org/10.3390/pharmaceutics10040273.

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Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of penetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail pathologies. In this work, different chemical substances have been evaluated as potential penetration enhancers. With this aim, the effect of different substances such as sodium lauryl sulfate (SLS), polyethylene glycol 300 (PEG 300), carbocysteine, N-acetylcysteine, lactic acid, potassium phosphate, Labrasol® an

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Vaishnavi, Wazulkar* Ankita Jadhav Swati Deshmukh. "Formulation And Evaluation of Herbal Nail Lacquer for Treatment of Onychomycosis." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2171–79. https://doi.org/10.5281/zenodo.15398260.

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Nails are the hard and durable epidermal. The nail plate is responsible for the penetration of the drug across it. There is the number of formulations with antifungal agents viz. gels, creams, and oral antifungal for the treatment of transungual infections. Among these entire nail lacquers is a new concept in treating nail infections. These nail lacquers are effective as monotherapy in the treatment of superficial, distal, and subungual diseases. The medicated lacquer preparations are generally used in fungal diseases. Use of this system avoids oral toxicity of antifungal drugs. It is associat

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Hui, Xiaoying, Zev Shainhouse, Hanafi Tanojo, et al. "Enhanced Human Nail Drug Delivery: Nail Inner Drug Content Assayed by New Unique Method." Journal of Pharmaceutical Sciences 91, no. 1 (2002): 189–95. http://dx.doi.org/10.1002/jps.10003.

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Vishal Verma. "Development and Evaluation of Antifungal Lacquer for Enhanced Transungual Drug Delivery." Knowledgeable Research A Multidisciplinary Journal 4, no. 05 (2025): 1–10. https://doi.org/10.57067/g2sjhn98.

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Onychomycosis, a mycotic nail infection caused primarily by dermatophytes, yeasts, and nondermatophyte molds, is an endemic condition in 5-10% of the world population. The tightly keratinous nature of the nail plate and its relatively slow growth rate constitute a significant barrier to effective drug delivery. Traditional treatment with oral antifungals and topical creams is often restricted by systemic toxicities, poor penetration of nails, and low patient compliance. Antifungal lacquers are a new choice with controlled drug delivery, sustained release, and improved patient compliance. The r

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Dhamoon, Rupinder K., Harvinder Popli, and Madhu Gupta. "Novel Drug Delivery Strategies for the Treatment of Onychomycosis." Pharmaceutical Nanotechnology 7, no. 1 (2019): 24–38. http://dx.doi.org/10.2174/2211738507666190228104031.

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Onychomycosis accounts for 50% of all nail disease cases and is commonly caused by dermatophytes. It was primarily considered a cosmetic problem but has been garnering attention lately due to its persistent nature and difficult treatment with relapses. With prolonged treatment duration and high cost involved in treating onychomycosis, several attempts have been made in overcoming the rigid nail barrier. The conventional treatment of onychomycosis involves oral and topical therapy. The oral antifungal agents though quite effective, are hepato-toxic and cause drug-drug interactions. Topical ther

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Puri, Vinam, Anna Froelich, Parinbhai Shah, Shernelle Pringle, Kevin Chen, and Bozena Michniak-Kohn. "Quality by Design Guided Development of Polymeric Nanospheres of Terbinafine Hydrochloride for Topical Treatment of Onychomycosis Using a Nano-Gel Formulation." Pharmaceutics 14, no. 10 (2022): 2170. http://dx.doi.org/10.3390/pharmaceutics14102170.

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Superficial fungal diseases of the skin and nails are an increasingly common occurrence globally, requiring effective topical treatment to avoid systemic adverse effects. Polymeric nanoparticles have demonstrated sustained and effective drug delivery in a variety of topical formulations. The aim of this project was to develop polymeric antifungal nanospheres containing terbinafine hydrochloride (TBH) to be loaded into a hydrogel formulation for topical nail drug delivery. A quality by design (QbD) approach was used to achieve optimized particles with the desired quality target product profile

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Šveikauskaitė, Indrė, Alius Pockevičius, and Vitalis Briedis. "Potential of Chemical and Physical Enhancers for Transungual Delivery of Amorolfine Hydrochloride." Materials 12, no. 7 (2019): 1028. http://dx.doi.org/10.3390/ma12071028.

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Topical monotherapy of nail infection is limited by poor drug permeability into the human nail plate. Numerous substances and methods are applied to improve the antifungal agent delivery across the nail plate. This work aimed to evaluate the effect of chemical and physical enhancers on the accumulation and permeation of amorolfine hydrochloride through human nail clippings. Polymeric nail lacquers with Eudragit E100 were developed as a potentially suitable delivery system for amorolfine hydrochloride. Incorporating thioglycolic acid and urea into formulations provided increased accumulation of

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Kumar, Shivam, Hiralal Prajapati, and Tarun Parashar. "Prospective of Nail Lacquer in Nanoparticles for Transungal Delivery of Antifungal." International Journal of Research and Scientific Innovation XII, no. V (2025): 280–86. https://doi.org/10.51244/ijrsi.2025.120500022.

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Onychomyosis is a difficult-to-treat fungal infection of the nails that frequently results in thickness and discolouration of the afflicted nail plate. Dermatophytes are the main cause of this illness. While oral medicines frequently result in systemic side effects and drug interactions, inadequate nail penetration has hindered the development of effective topical remedies. An important development in dermatology is the use of nail lacquer based on nano formulations to administer antifungals, including amorolfine, both transungally and subungally. It has been shown that amorofline can pierce h

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Bhairy, Srinivas, Alfiha Momin, Mugdha Pednekar, et al. "A Note on the Current Status of the Trans-ungual Delivery of Poorly Soluble Drugs at a Glance: Formulation Perspective." Asian Journal of Research in Infectious Diseases 12, no. 3 (2023): 1–21. http://dx.doi.org/10.9734/ajrid/2023/v12i3244.

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The Trans ungual drug delivery (TUDD) system involves the delivery of drugs through the hard keratinized nail plate. Topical treatment is ideal for treating nail diseases because it has localized effects, resulting in fewer systemic side effects and perhaps better adherence. Conventional formulations have failed to promote nail adhesion and medication absorption due to the nail's highly keratinized hydrophilic nature, which obstructs drug absorption. Systemic therapy has several side effects and a high rate of recurrence, whereas surgery is painful and invasive. As a result, there is a definit

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Dobler, Dorota, Mona Gerber, Thomas M. Schmidts, Frank Runkel, and Peggy Schlupp. "Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate." Pharmaceutics 14, no. 12 (2022): 2552. http://dx.doi.org/10.3390/pharmaceutics14122552.

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Human nail diseases, mostly caused by fungal infections, are common and difficult to treat. The development and testing of new drugs and drug delivery systems for the treatment of nail diseases is often limited by the lack of human nail material for permeation studies. Animal material is frequently used, but there are only few comparative data on the human nail plate, and there is neither a standardized test design nor a nail bed analogue to study drug uptake into the nail. In this study, a new permeation device was developed for permeation studies, and the permeation behavior of three model s

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Puri, Vinam, Riya Savla, Kevin Chen, Keyaara Robinson, Amitkumar Virani, and Bozena Michniak-Kohn. "Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate." Pharmaceutics 14, no. 10 (2022): 2204. http://dx.doi.org/10.3390/pharmaceutics14102204.

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The fungal disease of the nail, onychomycosis, which is also the most prevalent nail disturbance, demands effective topical treatment options considering the possible adverse effects of systemic antifungal therapy. The current work is focused on development of an adhesive and resistant, drug-delivering and permeation-enhancing polymeric film containing econazole nitrate (ECN) for topical antifungal treatment. The development of the lacquer formulation was guided by the Quality by Design approach to achieve the critical quality attributes needed to obtain the product of desired quality. Eudragi

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Diptee, Marchande. "Formulation and Evaluation of Medicated Nail Lacquer for the Treatment of Onychomycosis." International Journal of Pharmacy and Biological Sciences (IJPBS) 14, no. 3 (2024): 26–34. https://doi.org/10.5281/zenodo.13294084.

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AbstractAims: The objective of the research work was to study about medicated antifungal nail lacquer for the treatment of Onychomycosis. Medicated nail lacquers generally act on a principle that it will form a film on the application surface from which the drug is released at a controlled rate for an extended period. Methods: The purpose of the investigation was to formulate and evaluate the Luliconazole nail lacquer as an ungual drug delivery system for the treatment of onychomycosis. Luliconazole an antifungal class of a drug was chosen along with Eudragit RS-100, Ethyl cellulose, Butyl ace

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Murdan, Sudaxshina. "Drug delivery to the nail following topical application." International Journal of Pharmaceutics 236, no. 1-2 (2002): 1–26. http://dx.doi.org/10.1016/s0378-5173(01)00989-9.

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Yew, Yik Weng, Crystal Zhen Yu Phuan, Xiahong Zhao, Eugene Sern Ting Tan, Wei-Sheng Chong, and Hong Liang Tey. "Novel transdermal device for delivery of triamcinolone for nail psoriasis treatment." Annals of the Academy of Medicine, Singapore 51, no. 1 (2022): 16–23. http://dx.doi.org/10.47102/annals-acadmedsg.2021380.

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ABSTRACT Introduction: Nail psoriasis treatment is challenging due to difficult drug delivery and systemic therapy toxicities. Self-dissolvable microneedle patches embedded with corticosteroids offers a potentially rapid, minimally invasive drug delivery platform with good efficacy and minimal adverse side effects. Methods: We conducted a 4-month prospective randomised controlled trial. Subjects with psoriatic nails were randomised to receive microneedle device delivered topical steroids on one hand and control treatment (topical Daivobet gel) on the other. Two independent dermatologists blind

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Šveikauskaitė, Indrė, and Vitalis Briedis. "Potential of Naftifine Application for Transungual Delivery." Molecules 25, no. 13 (2020): 3043. http://dx.doi.org/10.3390/molecules25133043.

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Naftifine is used to treat fungal skin infections as it inhibits dermatophytes, which are the cause of onychomycosis. However, naftifine’s ability to permeate the human nail barrier has not been investigated, thus, the antimycotic potential is not clearly established. This work aims to evaluate the effect of penetration enhancing factors on the accumulation of naftifine hydrochloride through human nail clippings. Naftifine polymeric nail lacquers with Eudragit RL100 were developed as a suitable delivery system. Low penetration of naftifine into nail has been determined as less than 10% of appl

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Pollard, Thomas D., Margherita Bonetti, Adam Day, et al. "Printing Drugs onto Nails for Effective Treatment of Onychomycosis." Pharmaceutics 14, no. 2 (2022): 448. http://dx.doi.org/10.3390/pharmaceutics14020448.

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Inkjet printing (IJP) is an emerging technology for the precision dosing of medicines. We report, for the first time, the printing of the antifungal drug terbinafine hydrochloride directly onto nails for the treatment of onychomycosis. A commercial cosmetic nail printer was modified by removing the ink from the cartridge and replacing it with an in-house prepared drug-loaded ink. The drug-loaded ink was designed so that it was comparable to the commercial ink for key printability properties. Linear drug dosing was shown by changing the lightness of the colour selected for printing (R2 = 0.977)

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Tampucci, Silvia, Eleonora Terreni, Erica Zucchetti, Susi Burgalassi, Patrizia Chetoni, and Daniela Monti. "Formulations Based on Natural Ingredients for the Treatment of Nail Diseases." Current Pharmaceutical Design 26, no. 5 (2020): 556–65. http://dx.doi.org/10.2174/1381612826666200122150248.

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Nail is a strong and resistant structure, characterized by a low permeability to foreign molecules. Nails can be subjected to many diseases, among which fungal infections (e.g. onchomycosis) are the most common and responsible for nail structure alteration. Many formulations have been produced for the delivery of active ingredients to treat nail disorders, based on newly synthesized active molecules or containing chemical enhancers or chemically-modified polymers able to improve the drug transungual penetration. To avoid permanent alterations of the nail structure due to the use of chemical co

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Saner, Manish V., Abhijeet D. Kulkarni, and Chandrakantsing V. Pardeshi. "Insights into drug delivery across the nail plate barrier." Journal of Drug Targeting 22, no. 9 (2014): 769–89. http://dx.doi.org/10.3109/1061186x.2014.929138.

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Bhise, Kiran, Sabreen Jan, and Divyakumar Bora. "Preungual drug delivery systems of Terbinafine Hydrochloride Nail Lacquer." Asian Journal of Pharmaceutics 2, no. 1 (2008): 53. http://dx.doi.org/10.4103/0973-8398.41567.

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Murdan, Sudaxshina. "1st Meeting on Topical Drug Delivery to the Nail." Expert Opinion on Drug Delivery 4, no. 4 (2007): 453–55. http://dx.doi.org/10.1517/17425247.4.4.453.

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Dhamoon, Rupinder K., Ramesh K. Goyal, Harvinder Popli, and Madhu Gupta. "Luliconazole-Loaded Thermosensitive Hydrogel as Aqueous based Nail Lacquer for the Treatment of Onychomycosis." Drug Delivery Letters 9, no. 4 (2019): 321–29. http://dx.doi.org/10.2174/2210303109666190520081552.

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Background: Onychomycosis is a nail fungal infection which accounts for 50% of the nail diseases and is characterized by disfigurement and discoloration of nails. The current therapy includes oral and topical formulations both of which come with their own drawbacks. This has left a room for developing patient- compliant novel strategies which can facilitate drug delivery deeper into the nails effectively. Objective: The main objective of the present work was to develop and evaluate in situ gelling thermosensitive hydrogel as an aqueous nail lacquer for the treatment of onychomycosis. The idea

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Nair, Anroop B., Bandar Aldhubiab, Jigar Shah, et al. "Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole." Pharmaceutics 15, no. 5 (2023): 1422. http://dx.doi.org/10.3390/pharmaceutics15051422.

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The efficacy of topical antifungal therapy in onychomycosis has been hindered by the failure of the antimycotic to permeate the nail plate. This research aims to design and develop a transungual system for the effective delivery of efinaconazole utilizing constant voltage iontophoresis. Seven prototype drug-loaded hydrogel formulations (E1–E7) were prepared to assess the influence of solvent (ethanol) and cosolvent (Labrasol®) on transungual delivery. Optimization was performed to evaluate the effect of three independent variables; voltage, solvent-to-cosolvent ratio, and penetration enhancer

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Ullah, Kamran Hidayat, Faisal Raza, Syed Mohsin Munawar, et al. "Poloxamer 407 Based Gel Formulations for Transungual Delivery of Hydrophobic Drugs: Selection and Optimization of Potential Additives." Polymers 13, no. 19 (2021): 3376. http://dx.doi.org/10.3390/polym13193376.

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The current study aimed to develop poloxamer 407 (P407) gel for transungual delivery of antifungal hydrophobic drugs with sufficient gel strength and drug loading. Gel strength and drug loading of P407 gel was improved by use of functional additives. Hydration enhancement effect was used to select optimum nail penetration enhancer. Face-centered central composite design (FCCCD) was used to observe the effect of the selected penetration enhancer (thioglycolic acid (TGA)) and cosolvent (ethanol) on gelation behavior to develop formulation with enough loading of hydrophobic drug, i.e., terbinafin

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Abadi, Danielle, and Vesna Zderic. "Ultrasound‐mediated nail drug delivery system to treat fungal disorders." Journal of the Acoustical Society of America 127, no. 3 (2010): 1941. http://dx.doi.org/10.1121/1.3384895.

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Cutrín-Gómez, Elena, Soledad Anguiano-Igea, M. Delgado-Charro, José Gómez-Amoza, and Francisco Otero-Espinar. "Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer." Pharmaceutics 10, no. 3 (2018): 156. http://dx.doi.org/10.3390/pharmaceutics10030156.

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Aqueous-based nail lacquers have shown potential in promoting the diffusion of drugs into the nail. In our laboratory, we have recently developed a transungual delivery system based on an aqueous dispersion of cyclodextrin-poloxamer soluble polypseudorotaxanes, supramolecular host−guest assemblies that improves the drug permeation into the nail. However, the high-water content and the rheological and adhesive properties of this lacquer negatively affect properties that play a fundamental role in the patients’ acceptance such as stickiness, nail film formation or drying rate, properties. In thi

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Belikov, Andrey V., Anastasia D. Tavalinskaya, Sergey N. Smirnov, and Andrey N. Sergeev. "Active Er-laser drug delivery using drug-impregnated gel for treatment of nail diseases." Biomedical Optics Express 10, no. 7 (2019): 3232. http://dx.doi.org/10.1364/boe.10.003232.

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Šveikauskaitė, Indrė, and Vitalis Briedis. "Effect of Film-Forming Polymers on Release of Naftifine Hydrochloride from Nail Lacquers." International Journal of Polymer Science 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/1476270.

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The successful topical therapy of onychomycosis depends on effective drug release and penetration into nail, which can be achieved by using an adequately developed delivery system. This study evaluated and compared effect of film-forming polymers Eudragit RL100, Eudragit RS100, and ethyl cellulose on naftifine hydrochloride release from experimental nail lacquer formulations. Quality of formulations was evaluated by determining drying time and water resistance. Interactions between active pharmaceutical ingredient and excipients were investigated using microcalorimetry and FT-IR. Optimization

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Barot, Bhavesh S., Punit B. Parejiya, Hetal K. Patel, Dharmik M. Mehta, and Pragna K. Shelat. "Drug Delivery to the Nail: Therapeutic Options and Challenges for Onychomycosis." Critical Reviews in Therapeutic Drug Carrier Systems 31, no. 6 (2014): 459–94. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.2014008464.

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