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Relevant bibliographies by topics / Naja-naja sumatrana

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Academic literature on the topic 'Naja-naja sumatrana'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Naja-naja sumatrana"

1

Cham, Gregory, Francis Lim, Arul Earnest, and Ponnampalam Gopalakrishnakone. "Cross-Reactivity against Naja sumatrana (Black Spitting Cobra) Envenoming from the Haffkine Antivenom in a Mouse Model." ISRN Toxicology 2013 (August 12, 2013): 1–5. http://dx.doi.org/10.1155/2013/247645.

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Naja sumatrana is the dominant cobra species in Malaysia, Singapore, Borneo, and Sumatra, and it does not have specific antivenom. The Haffkine antivenom has been advocated instead. This study aims to determine the efficacy of this antivenom against Naja sumatrana envenoming using a mouse model. Methods. Male Swiss albino mice were used. Intravenous LD50 was first determined separately for Naja naja and Naja sumatrana venom. ED50 was determined by preincubating antivenom with each venom at 2.5 LD50 before administering the mixture into the tail vein. Validation was carried out using a challeng

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2

Chong, Ho Phin, Kae Yi Tan, Bing-Sin Liu, Wang-Chou Sung, and Choo Hock Tan. "Cytotoxicity of Venoms and Cytotoxins from Asiatic Cobras (Naja kaouthia, Naja sumatrana, Naja atra) and Neutralization by Antivenoms from Thailand, Vietnam, and Taiwan." Toxins 14, no. 5 (2022): 334. http://dx.doi.org/10.3390/toxins14050334.

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Envenoming by cobras (Naja spp.) often results in extensive local tissue necrosis when optimal treatment with antivenom is not available. This study investigated the cytotoxicity of venoms and purified cytotoxins from the Monocled Cobra (Naja kaouthia), Taiwan Cobra (Naja atra), and Equatorial Spitting Cobra (Naja sumatrana) in a mouse fibroblast cell line, followed by neutralization of the cytotoxicity by three regional antivenoms: the Thai Naja kaouthia monovalent antivenom (NkMAV), Vietnamese snake antivenom (SAV) and Taiwanese Neuro bivalent antivenom (NBAV). The cytotoxins of N. atra (NA-

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3

Tan, Choo, Kin Wong, Nget Tan, Tzu Ng, and Kae Tan. "Distinctive Distribution of Secretory Phospholipases A2 in the Venoms of Afro-Asian Cobras (Subgenus: Naja, Afronaja, Boulengerina and Uraeus)." Toxins 11, no. 2 (2019): 116. http://dx.doi.org/10.3390/toxins11020116.

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The protein abundances of phospholipases A2 in cobra venom proteomes appear to vary among cobra species. To determine the unique distribution of snake venom phospholipases A2 (svPLA2) in the cobras, the svPLA2 activities for 15 cobra species were examined with an acidimetric and a colorimetric assay, using egg yolk suspension and 4-nitro-3-octanoyloxy benzoic acid (NOBA) as the substrate. The colorimetric assay showed significant correlation between svPLA2 enzymatic activities with the svPLA2 protein abundances in venoms. High svPLA2 activities were observed in the venoms of Asiatic spitting c

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4

Ismail, Ahmad Khaldun, Zhi Xuan Ng, Syahirah Rezwan Eskandar, Hamelda Tanisha Ganaprakasam, and Zainalabidin Mohamed. "The frequency, clinical characteristics and outcomes of Naja species related injuries in Malaysia consulted to Remote Envenomation Consultancy Services from 2020–2023." PLOS Neglected Tropical Diseases 19, no. 7 (2025): e0013271. https://doi.org/10.1371/journal.pntd.0013271.

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Naja species bites and envenomation are common in Malaysia. This retrospective cohort study of diagnosed Naja species cases consulted to Remote Envenomation Consultancy Services (RECS) from 2020 to 2023. This study aimed to identify the frequency, geographical distribution, clinical features, treatments, and outcomes of Naja species-related injuries. Data was extracted following the approval of the institutional research ethics committee and all patient’s information were kept anonymous. From 4474 RECS consultations, 512 incidents were diagnosed as caused by Naja species. Naja kaouthia case co

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5

Tan, Choo Hock, Kae Yi Tan, Kin Ying Wong, Nget Hong Tan, and Ho Phin Chong. "Equatorial Spitting Cobra (Naja sumatrana) from Malaysia (Negeri Sembilan and Penang), Southern Thailand, and Sumatra: Comparative Venom Proteomics, Immunoreactivity and Cross-Neutralization by Antivenom." Toxins 14, no. 8 (2022): 522. http://dx.doi.org/10.3390/toxins14080522.

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The Equatorial Spitting Cobra (Naja sumatrana) is a medically important venomous snake species in Southeast Asia. Its wide geographical distribution implies potential intra-specific venom variation, while there is no species-specific antivenom available to treat its envenoming. Applying a protein-decomplexing proteomic approach, the study showed that three-finger toxins (3FTX), followed by phospholipases A2 (PLA2), were the major proteins well-conserved across N. sumatrana venoms of different locales. Variations were noted in the subtypes and relative abundances of venom proteins. Of note, alp

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6

Chong, Ho Phin, Kae Yi Tan, Nget Hong Tan, and Choo Hock Tan. "Exploring the Diversity and Novelty of Toxin Genes in Naja sumatrana, the Equatorial Spitting Cobra from Malaysia through De Novo Venom-Gland Transcriptomics." Toxins 11, no. 2 (2019): 104. http://dx.doi.org/10.3390/toxins11020104.

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The equatorial spitting cobra, Naja sumatrana, is a distinct species of medically important venomous snakes, listed as WHO Category 1 in Southeast Asia. The diversity of its venom genes has not been comprehensively examined, although a few toxin sequences annotated to Naja sputatrix were reported previously through cloning studies. To investigate this species venom genes’ diversity, de novo venom-gland transcriptomics of N. sumatrana from West Malaysia was conducted using next-generation sequencing technology. Genes encoding toxins represented only 60 of the 55,396 transcripts, but were highly

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7

Zukifli, Nor Asyikin, Zalikha Ibrahim, Iekhsan Othman, et al. "In Vitro neurotoxicity and myotoxicity of Malaysian Naja sumatrana and Naja kaouthia venoms: Neutralization by monovalent and Neuro Polyvalent Antivenoms from Thailand." PLOS ONE 17, no. 9 (2022): e0274488. http://dx.doi.org/10.1371/journal.pone.0274488.

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Naja sumatrana and Naja kaouthia are medically important elapids species found in Southeast Asia. Snake bite envenoming caused by these species may lead to morbidity or mortality if not treated with the appropriate antivenom. In this study, the in vitro neurotoxic and myotoxic effects N. sumatrana and N. kaouthia venoms from Malaysian specimens were assessed and compared. In addition, the neutralizing capability of Cobra Antivenom (CAV), King Cobra Antivenom (KCAV) and Neuro Polyvalent Antivenom (NPAV) from Thailand were compared. Both venoms produced concentration-dependent neurotoxic and myo

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8

Zainal Abidin, Syafiq, Yee Lee, Iekhsan Othman, and Rakesh Naidu. "Malaysian Cobra Venom: A Potential Source of Anti-Cancer Therapeutic Agents." Toxins 11, no. 2 (2019): 75. http://dx.doi.org/10.3390/toxins11020075.

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Cancer is a deadly disease and there is an urgent need for the development of effective and safe therapeutic agents to treat it. Snake venom is a complex mixture of bioactive proteins that represents an attractive source of novel and naturally-derived anticancer agents. Malaysia is one of the world’s most biodiverse countries and is home to various venomous snake species, including cobras. Naja kaouthia, Naja sumatrana, and Ophiophagus hannah are three of the most common cobra species in Malaysia and are of medical importance. Over the past decades, snake venom has been identified as a potenti

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9

Abdullah, Nur Atiqah Haizum, Muhamad Rusdi Ahmad Rusmili, Syafiq Asnawi Zainal Abidin, Mohd Farooq Shaikh, Wayne C. Hodgson, and Iekhsan Othman. "Isolation and Characterization of A2-EPTX-Nsm1a, a Secretory Phospholipase A2 from Malaysian Spitting Cobra (Naja sumatrana) Venom." Toxins 13, no. 12 (2021): 859. http://dx.doi.org/10.3390/toxins13120859.

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Phospholipase A2 (PLA2) toxins are one of the main toxin families found in snake venom. PLA2 toxins are associated with various detrimental effects, including neurotoxicity, myotoxicity, hemostatic disturbances, nephrotoxicity, edema, and inflammation. Although Naja sumatrana venom contains substantial quantities of PLA2 components, there is limited information on the function and activities of PLA2 toxins from the venom. In this study, a secretory PLA2 from the venom of Malaysian N. sumatrana, subsequently named A2-EPTX-Nsm1a, was isolated, purified, and characterized. A2-EPTX-Nsm1a was purif

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10

Tansuwannarat, Phantakan, Achara Tongpoo, Suraphong Phongsawad, Charuwan Sriapha, Winai Wananukul, and Satariya Trakulsrichai. "A Retrospective Cohort Study of Cobra Envenomation: Clinical Characteristics, Treatments, and Outcomes." Toxins 15, no. 7 (2023): 468. http://dx.doi.org/10.3390/toxins15070468.

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This study investigated the clinical characteristics, treatments, and outcomes of envenomation involving cobra species in Thailand (Naja kaouthia, Naja siamensis, and Naja sumatrana). Data of patients who had been bitten by a cobra or inoculated via the eyes/skin in 2018–2021 were obtained from the Ramathibodi Poison Center. There were 1045 patients admitted during the 4-year study period (bite, n = 539; ocular/dermal inoculation, n = 506). Almost all patients with ocular/dermal inoculation had eye involvement and ocular injuries, but none had neurological effects. Most of the patients bitten

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