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Dissertations / Theses on the topic 'Naloxon'

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Published: 4 June 2021

Last updated: 27 April 2022

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1

Warnecke, Marc. "Die Wirkung des Opioidantagonisten Naloxon auf experimentell induziertes Craving bei Nikotinabhängigkeit." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-16085.

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2

Strotmann, Heike. "Der Einfluss von Naloxon auf die Splanchnikusperfusion im chronisch instrumentierten, wachen Hund." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974874973.

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3

Kolbow, Julia [Verfasser]. "Zur Wirkung von Methylnaltrexon und Naloxon auf eine experimentelle Loperamid-induzierte Obstipation bei gesunden Probanden / Julia Kolbow." Greifswald : Universitätsbibliothek Greifswald, 2017. http://d-nb.info/1124102590/34.

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4

Becklas, Michael [Verfasser], and Fritz [Akademischer Betreuer] Mertzlufft. "Der intravenöse Morphintest inklusive Gegentestung mit Naloxon bei Patienten mit chronischen Schmerzen : eine retrospektive Analyse von 2005 bis Mai 2007 / Michael Becklas. Betreuer: Fritz Mertzlufft." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051095913/34.

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5

Pires, Oscar César. "Efeitos da naloxona, da metissergida e da fentolamina, por via subaracnóidea, sobre a modulação da dor, através do teste de formalina modificado, em ratos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-08032010-094321/.

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Aferentes nociceptivos primários se projetam da periferia para o corno posterior da medula espinhal onde ativam grande número de neurônios de segunda ordem e de projeção. Há evidências de que a passagem de informações nociceptivas pelo CPME seguindo para níveis rostrais do sistema nervoso central, sofre profundas influências excitatórias e inibitórias. A presente pesquisa teve como objetivo comparar os efeitos dos antagonistas de opióides (naloxona), de serotonina (metissergida) e de noradrenalina (fentolamina), administrados por via subaracnóidea, sobre as fases I, intermediária e II do teste

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6

Gangal, Neha S. M. S. "Association between a Law Change Allowing Pharmacists to Provide Naloxone under a Physician-Approved Protocol and Naloxone Dispensing Rates." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin159216924639219.

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7

Shah, Ruby. "Naloxone Utilization in a Tertiary Care Medical Center." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/281779.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>The purpose of this research project was to review the use of naloxone for oversedation events from 2008-2011 at the Mayo Clinic Hospital in Phoenix, Arizona. Opiates are generally an accepted form of acute and chronic pain management. Opiate analgesic use has increased in past decades due to several factors including cultural and healthcare ideas on the importance of pain management, as well as the availability, cost, and marketing

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8

Dowling, Karilynn, Marc Fleming, Sarah Melton, and Nicholas E. Hagemeier. "Quaternary Prevention: Four States’ Approaches to Naloxone Dissemination." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/1411.

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Naloxone has received increased public health attention in recent years given its effectiveness in the reversal of opioid overdoses. Despite continued increases in overdose death rates attributable to opioids, approaches to naloxone dissemination, prescribing and dispensing are quite variable across states. On the public health prevention continuum, naloxone dissemination and use could be considered quaternary prevention —actions taken to identify individuals at risk of over-medication, protect them from new medical invasion and suggest interventions which are ethically acceptable. This presen

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9

Hollinden, Gary Edward. "Role of calcium in neural insult /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487263399023472.

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10

Vaccarino, Anthony Leonard. "Naloxone analgesia in BALBc mice : a dose-dependent relationship." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66239.

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11

Hagemeier, Nicholas E. "Naloxone: The State of Co-Prescribing and Co-Dispensing." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5425.

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12

Junior, José Oswaldo de Oliveira. "Efeito analgésico periférico do tramadol em modelo de dor pós-operatória em ratos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-02052016-091403/.

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INTRODUÇÃO: Tramadol é conhecido como um fármaco analgésico de ação central utilizado no tratamento de dores de intensidades moderada a forte. Efeito analgésico local já foi demonstrado. É, em parte, semelhante ao efeito anestésico local, mas outros mecanismos permanecem desconhecidos. O papel de receptores opioides periféricos na analgesia do tramadol na dor pós-operatória não é conhecido. Neste estudo, foi estudado o papel dos receptores opioides no efeito analgésico local do tramadol em modelo de dor por incisão plantar. MÉTODOS: Ratos machos jovens foram submetidos à incisão plantar e no p

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13

Yamamoto, Rinah T. "Glucose alters pain-response and other opiate-related behaviors /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2005.

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Thesis (Ph.D.)--Tufts University, 2005.<br>Adviser: Robin B. Kanarek. Submitted to the Dept. of Psychology. Includes bibliographical references (leaves 79-91). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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14

IMPERATORI, JOEL. "Narcan dans les intoxications ethyliques graves." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20141.

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15

McDonald, Rebecca Silvia. "Non-injectable naloxone for the prevention of opioid overdose deaths." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/noninjectable-naloxone-for-the-prevention-of-opioid-overdose-deaths(854e176a-6483-4f70-9340-b3806e03fb21).html.

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Background and Aims: Naloxone is the standard treatment for reversal of opioid overdoses. Due to risk of needle-stick injury, licensed injectable naloxone products are not well suited for layperson administration or take-home naloxone distribution. The aims of this thesis are threefold: Aim 1) assess the effectiveness and limitations of take-home naloxone provision (any naloxone formulation); Aim 2) compare the pharmacokinetic profiles of non-injectable naloxone formulations; Aim 3) identify non-injectable formulations that provide early naloxone exposure similar to a 0.4mg intramuscular dose.

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16

Picon, Paulo Dornelles. "Efeito de altas doses de naloxone nas respostas hemodinamicas ao exercicio." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 1990. http://hdl.handle.net/10183/179780.

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Existem vArias evidências exPerimentais e clinicas de que os Opióides Endógenos exercem um papel importante no controle cardiovascular. Com o objetivo de avaliaa influência destes peptideos, liberados durante o exercicio, sobre as respostas cardiovasculares, metabólicas e da percepção do esforco ao exercicio sub-màximo, foi administrado um antagonista opióide: Naloxone (14 mg), de maneira duplo-cega e, á 10 jovens normais, não treinados. Os individuas pedalaram durante 60 minutos, divididos em três estàgios de 20 minutos sob cargas que atingiram . (médias ± DP) 48 ± 7, 62 ± 4 e 83 ± 5% da freq

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17

Stoll, Scott Thomas. "Naloxone Potentiation of Epinephrine Induced Vasoconstriction in Canine Skeletal Muscle Arteries." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc277685/.

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Naloxone (NX) potentiated epinephrine (EPI) induced submaximal vasoconstriction in canine renal and skeletal muscle arterial segments, yet had no vasoconstrictor action alone. Developed tension generated in-vitro by 4 x 1mm. O.D. rings from 1st degree branches of canine femoral arteries was expressed as % of KCI induced maximum response. NX (10^-5 M) potentiated EPI induced submaximal contractions (34.2%) significantly more than contractions induced by norepinephrine, phenylephrine, lofexidine, ADH, KCI and serotonin (13.8,13.4,4.7,13.5,14.4 and 11.4% respectively). The NX response was unaffec

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18

Frempong, Dorcas, Dhruv Mishra, and Ashana Puri. "Microneedle-mediated transdermal delivery of naloxone hydrochloride for treatment of opioid addiction." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/41.

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Opioid addiction is a serious national crisis impacting public health. Naloxone is a potent opioid antagonist administered to reverse the effects of opioid overdose. It is currently administered as an intravenous, intramuscular, subcutaneous injection and intranasal spray. The short duration of action of naloxone results in requirement of frequent re-dosing, especially in cases of larger overdoses, which may impact successful outcomes, especially when drug administration is provided by non-medical personnel as in case of intranasal sprays. These weaknesses necessitate the development of a non-

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19

Woollett, Jaclyn. "Rural Jail Administrators Perceptions of Take-Home Naloxone to Control Opioid Overdoses." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/4344.

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Opioid overdoses and overdose deaths have increased significantly throughout the United States. Naloxone distribution has become a harm reduction strategy that has proven effective in reducing opioid overdoses in urban areas through drug treatment centers and needle exchange programs. However, limited research is available on the efficacy and feasibility of these programs in rural locations and other nontraditional settings. Guided by harm reduction theory, the purpose of this qualitative phenomenological study was to address this gap by exploring the feasibility of implementing a take home na

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20

SERIVE-MATTEI, JEAN-MICHEL. "Etude des effets cliniques de la naloxone sur la reprise du transit digestif apres chirurgie abdominale." Montpellier 1, 1988. http://www.theses.fr/1988MON11086.

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21

SABOYE, MILLARD DE MONTRION NATHALIE. "Role des antagonistes du systeme opioide (naloxone et naltrexone) dans les obesites avec dysovulation." Toulouse 3, 1990. http://www.theses.fr/1990TOU31551.

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22

del, Campo Martin. "Diurnal variations in the psychological and endocrine responses to naloxone administration in man." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597269.

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5 studies investigated the circadian variation (i.e. during each 24 hours period) in endogenous opioid system (EOS) regulation of mood and neuroendocrine function in 40 male normal controls, 8 female psychiatric patients with depressive syndromes and 8 matched controls (i.e. matched with the depressed patients for age and sex). Psychological, endocrine and cardiovascular responses to the opioid antagonist naloxone were measured at different times of the day. Each subject was used as his/her own control by having successive administrations of naloxone and saline solution, or vice-versa. Naloxon

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23

Strobel, Spencer. "A pilot study of an emergency department's overdose education and naloxone distribution program." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21257.

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Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Opioid overdoses are increasing and several efforts are being made to reduce this problem. One potential solution is overdose education and naloxone distribution. Project ASSERT began distributing naloxone in conjunction with its o

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24

Lindow, Stephen William. "The investigation of control mechanisms of oxytocin secretion in human pregnancy, labour and breast feeding." Thesis, University of Hull, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342958.

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25

Salwan, A., Nicholas E. Hagemeier, Karilynn Dowling, et al. "Community Pharmacist Engagement in Co-Dispensing Naloxone to Patients at Risk for Opioid Overdose." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/5427.

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26

John, Verity Jayne. "The time course of naloxone-induced recurrence of mustard oil-evoked jaw muscle electromyographic activity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0026/MQ40867.pdf.

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27

Poist, Jennifer, Regina Wu, Lourdes Peralta, and Marion Slack. "Prescriber Knowledge and Perception of Naloxone Use for Opioid Overdose Reversal among Intravenous Drug Users." The University of Arizona, 2015. http://hdl.handle.net/10150/614097.

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Class of 2015 Abstract<br>Objectives: Evaluate prescriber knowledge on naloxone use for opioid overdose reversals in intravenous drug users. Interview prescribers on their perceptions about intravenous drug users, syringe access programs, and other related topics. Subjects: Prescribers and medical professionals in the State of Arizona. Methods: Medical facilities were contacted by email, fax, or telephone requesting for prescribers to complete the survey and return by email or fax, or call to schedule a face-to-face appointment. The respondents of the survey were kept anonymous and were p

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28

Odunayo, Adesola DeClue Amy. "Immunomodulatory effects of opioids." Diss., Columbia, Mo. : University of Missouri-Columbia, 2010. http://hdl.handle.net/10355/.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on July 13, 2010). Thesis advisor: Amy DeClue. "May 2010" Includes bibliographical references.

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29

Ardid, Denis. "Effet antinociceptif des antidepresseurs : determination du niveau d'action et des mecanismes neurobiochimiques impliques." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13905.

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30

Aguilar, Carlos A. M. D. ""Predictors of inpatient narcotic overdose in a non-surgical population"." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342728730.

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31

Martins, Herlon Saraiva. "Efeitos hemodinâmicos e metabólicos da terlipressina ou naloxona na ressuscitação cardiopulmonar: estudo experimental, randomizado e controlado." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-19122011-111701/.

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Introdução: O prognóstico da parada cardiorrespiratória (PCR) em ritmo não chocável (assistolia/atividade elétrica sem pulso) é ruim e não melhorou significativamente nas últimas décadas. Embora a epinefrina seja o vasopressor recomendado, há evidências de que ela eleva o consumo de oxigênio, reduz a pressão de perfusão subendocárdica, causa grave disfunção miocárdica e piora a microcirculação cerebral durante a ressuscitação cardiopulmonar. Vasopressina foi muito estudada nos últimos anos e não se mostrou superior à epinefrina. Naloxona e terlipressina têm sido cogitadas como potenciais vasop

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32

Stagg, Nicola Jane. "Reversal of Neuropathic Pain with Exercise is Mediated by Endogenous Opioids." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194833.

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Exercise is often prescribed for patients with chronic pain, but there is little objective evidence supporting this recommendation. Therefore, we tested the effect of moderate aerobic exercise on the sensory hypersensitivity produced in an animal model of neuropathic pain. Male rats that underwent unilateral ligation of the L5 and L6 spinal nerves (SNL) were divided into exercise-trained or sedentary groups. Exercise training was performed using a treadmill, beginning 7 days after surgery, and continued 5 days a week for 5 weeks. Animals were exercised 30 min/day, at a speed of 14-16 m/mi

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33

Ortencio, Kethye Priscila. "Efeitos da instilação de morfina na inflamação ocular induzida experimentalmente em coelhos /." Jaboticabal, 2013. http://hdl.handle.net/11449/88975.

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Orientador: José Luiz Laus<br>Banca: Paola Castro Moraes<br>Banca: Alexandre Pinto Ribeiro<br>Resumo: Avaliou-se o efeito da instilação local de morfina 1% sobre a expressão do fator de necrose tumoral alfa (TNF-alfa), da interleucina-1 beta (IL-1beta), da prostaglandina E2 (PGE2) e da mieloperoxidase (MPO) e a turbidez do humor aquoso (flaremetria a laser) em olhos de coelhos com uveíte induzida por injeção intravítrea de endotoxina. Empregou-se 30 leporinos da raça Nova Zelândia Branco, separados em 5 grupos (n=6), a saber : basal, grupo controle (GC), grupo morfina (GM), grupo naloxona (GN)

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34

Ortencio, Kethye Priscila [UNESP]. "Efeitos da instilação de morfina na inflamação ocular induzida experimentalmente em coelhos." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/88975.

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Made available in DSpace on 2014-06-11T19:23:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-07-04Bitstream added on 2014-06-13T20:50:55Z : No. of bitstreams: 1 000735507.pdf: 1411225 bytes, checksum: 8fbfb73fa3d61839b1f7a315321a5d4b (MD5)<br>Avaliou-se o efeito da instilação local de morfina 1% sobre a expressão do fator de necrose tumoral alfa (TNF-alfa), da interleucina-1 beta (IL-1beta), da prostaglandina E2 (PGE2) e da mieloperoxidase (MPO) e a turbidez do humor aquoso (flaremetria a laser) em olhos de coelhos com uveíte induzida por injeção intravítrea de endotoxina. Empregou

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35

Toumi, Mondher. "Modulation pharmacologique de la dyspnee chez l'asthmatique." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20114.

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36

Hickey, Matthew Sean. "Effects of opioid antagonism on thermoregulation during prolonged exercise in the heat." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-06112009-063109/.

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37

Clark, Angela K. "A Feasibility Study of a Group-based Opioid Overdose Prevention Educational Intervention." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427980151.

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38

Floriano, Maureen Elizabeth. "Models of Addiction and Health Seeking Behaviors: Understanding Participant Utilization of an Overdose Education and Naloxone Distribution Clinic." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1619772720856071.

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39

Coplin, Jordan. "Development and Implementation of an Evidence-Based Buprenorphine-Naloxone Medication Assisted Treatment Program in a Primary Care Setting." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/29591.

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Opioid abuse is one of the most significant drug-related public health threats in the United States (U.S. Drug Enforcement Agency, 2016). Approximately 115 Americans die every day from an opioid overdose in the United States (Center for Disease Control and Prevention, 2017). Coupled with counseling, medication assisted treatment (MAT) can successfully treat opioid use disorder and sustain recovery by providing a more individualized approach to therapy (Substance Abuse and Mental Health Services Administration, 2016). The purpose of this project was to assist a primary care clinic (PCC) in Fa

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40

Ahmadzadeh, Amin. "Effect of naloxone on serum luteinizing hormone concentrations during the early postpartum period and the estrous cycle in primiparous and multiparous holstein cows." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-05092009-040533/.

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McDonald, Elizabeth. "Hedonic Mechanisms of Weight Changes in Medication Assisted Treatment for Opioid Addiction." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/669.

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Opioid abuse and addiction affects more than 2.4 million people in the United States. Medication assisted treatment (MAT), in combination with counseling, is recognized as the most effective treatment for patients with opioid dependence and abuse. Although MAT is considered the most effective treatment, previous research has found clinically significant weight gain with methadone. The purpose of this study was to determine if hedonic eating behaviors, sugar cravings, and addictive like eating was related to weight gain in opioid addicted patients receiving methadone and buprenorphine/naloxone

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42

Martin, del Campo Laurents Alfonso F. "Diurnal variations in the psychological and endocrine responses to naloxene administration in man." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259634.

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Kobelt, Paula Anne. "Nasal Spray Can Save Lives: Engaging Emergency Department Nurses in the Provision of Naloxone Nasal Spray to High Risk Patients." Otterbein University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=otbn1493059037547445.

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44

Bennevi, Veronica, and Theres Lindqvist. "Systematisk granskning av metoder och strategier för att förhindra drogrelaterade dödsfall." Thesis, Malmö universitet, Malmö högskola, Institutionen för socialt arbete (SA), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-41516.

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The mortality in drug related deaths has increased in many countries, calling it an epidemic. Overdose caused by opioids have contributed to the increasing drug related deaths. This study aims to examine and compile which methods and strategies have shown to reduce the mortality in drug related deaths. Using a systematic review and no limitation to countries a mix of methods and strategies was found. Some Ministries of Health department list them as important in reducing damages and risk behavior related to addiction. The repressive approach that was historically dominated has shown less succe

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Apelt, Sabine M. [Verfasser], and Michael [Akademischer Betreuer] Soyka. "Safety and effectiveness of Buprenorphine-Naloxone sublingual tablet in the treatment of opioid use disorder / Sabine M. Apelt ; Betreuer: Michael Soyka." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1183572239/34.

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46

Moro, Juliana Vitti [UNESP]. "Efeitos cardiovasculares e respiratórios da infusão contínua ne naloxona ou tramadol, em coelhos anestesiados com isofluorano e submetidos à hipovolemia aguda." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/89083.

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Made available in DSpace on 2014-06-11T19:23:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-12-02Bitstream added on 2014-06-13T19:50:49Z : No. of bitstreams: 1 moro_jv_me_jabo.pdf: 306522 bytes, checksum: 44cb74f16669bfd812909add5b4a1dc0 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Para avaliar os efeitos da infusão contínua de naloxona ou tramadol sobre a resposta à hipovolemia aguda foram utilizados 40 coelhos adultos distribuídos em cinco grupos: grupo naloxona (GN), grupo tramadol 1 (GT1), grupo tramadol 3 (GT3), grupo tramadol 5 (GT5) e grupo cont

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Moro, Juliana Vitti. "Efeitos cardiovasculares e respiratórios da infusão contínua ne naloxona ou tramadol, em coelhos anestesiados com isofluorano e submetidos à hipovolemia aguda /." Jaboticabal : [s.n.], 2009. http://hdl.handle.net/11449/89083.

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Orientador: Newton Nunes<br>Banca: Paulo Sérgio Patto dos Santos<br>Banca: Celina Tie Nishimori Duque<br>Resumo: Para avaliar os efeitos da infusão contínua de naloxona ou tramadol sobre a resposta à hipovolemia aguda foram utilizados 40 coelhos adultos distribuídos em cinco grupos: grupo naloxona (GN), grupo tramadol 1 (GT1), grupo tramadol 3 (GT3), grupo tramadol 5 (GT5) e grupo controle (GC). Os animais foram induzidos (2,5 CAM) e mantidos (1,5 CAM) à anestesia com isofluorano e após 60 minutos receberam bolus de solução de NaCl a 0,9% (GC), de naloxona (GN) ou de diferentes doses de tramad

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48

Tseng, Raymond J. "Stress-induced suppression of natural killer cell activity during influenza viral infection the role of glucocorticoids and opioids /." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1148586277.

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Lee, Mao-Cheng 1973. "International and trafficking of Mu and Delta opioid receptors in rat primary cortical culture and their response to chronic naloxone and morphine treatment." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31256.

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The Mu and Delta opioid receptors (MOR & DOR) have been shown to undergo complex regulatory changes in response to ligand exposure in transfected cells. However, little is known regarding receptor regulation in neurons. In this study, we have investigated the internalization and trafficking of the MOR and DOR agonists, fluodemorphin (fluo-DRM) and fluo-demorphin-I (fluo-DLT-I), respectively, and the fate of these receptors following ligand binding. Experiments were performed on primary rat cortical neuronal cultures using a ligand binding internalization assay and immunocytochemistry. Incubati

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Diego, del Río Laura 1977. "Independent drug information for medicines management." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/129850.

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On the 50th anniversary of the creation of the first medicines information center, the core of this PhD Thesis offers an insider perspective and provides several examples of independent drug information, with a focus on new drugs. On the one hand, it provides an overview of the origins and challenges current medicines information centers within public healthcare organizations are experiencing. Several strategic lines aiming for information centers continue to meet drug information needs in the actual healthcare and economic context are presented. Additionally, various examples of independent d

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