Relevant bibliographies by topics / Nano medicine

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Nano medicine'

Author: Grafiati
Published: 4 June 2021
Last updated: 27 April 2022

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Journal articles on the topic "Nano medicine"

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Genin, Guy M., and Ram V. Devireddy. "MEs in Nano-Medicine." Mechanical Engineering 134, no. 06 (June 1, 2012): 36–41. http://dx.doi.org/10.1115/1.2012-jun-3.

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This article reviews the use of mechanical engineering techniques in the field of nano-engineered medicines. Nano-engineered solutions now exist for a range of medical diagnostics, therapeutics, and imaging, and are at the core of many of the current generation of regenerative medicine and tissue engineering strategies. Nanoparticles can be developed to absorb energy with high efficiency from photons of certain frequency ranges. The ability to understand specific diseases such as osteogenesis imperfecta based upon such fundamental analyses has been demonstrated by ASME member Sandra Shefelbine of Imperial College London in collaboration with the Buehler group. The tools of nanotechnology have enabled mechanical engineers to engineer the beginnings of an entirely new generation of cures and therapies, and this article has discussed just a sample. In order to serve as a forum for discussion of these advances ASME is recommissioning the Journal of Nanotechnology in Engineering and Medicine.
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Zhao, Xiaoqi, Jie Wang, Lei Wang, Shiming Ren, Zheng Hu, and Yamei Wang. "Preparation and properties of nano-TiO2-Chinese herbal medicine composite wood." BioResources 16, no. 2 (May 2, 2021): 4252–74. http://dx.doi.org/10.15376/biores.16.2.4252-4274.

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The sol-gel method was used to make nano-TiO2 and five Chinese herbal medicines of Sophora flavescens Alt., Hypericum perforatum L., Cnidium monnieri (L.) Cuss., Kochia scoparia (L.), and Zanthoxylum bungeanum Maxim. to prepare five kinds of nano-TiO2-Chinese herbal medicine composite anti-degradative wood. Populus tomentosa Carr was chosen as the wood sample. Indoor decay resistance test results showed that the resistance to weight gain and decay of nano-TiO2-Chinese herbal medicine composite anti-degradative wood noticeably increased compared with either Chinese herbal medicine modified wood or nano-TiO2 modified wood, reaching a strong decay resistance level. The results of the anti-loss test showed that the magnitude of loss of wood samples treated with nano-TiO2 and Chinese herbal medicine was noticeably reduced compared with that with just Chinese herbal medicine. It was found by scanning electron microscopy that the nano-TiO2 particles and the Chinese herbal medicine enter the wood cell cavity, and the wood vessels and pits were the main permeation channels. Fourier transform infrared analysis results showed that nano-TiO2 could not only enter the wood interior, and associate with wood components through physical adsorption to form hydrogen bonds, but also through the carboxyl groups in cellulose and hemicellulose, or the phenolic hydroxyl group in lignin, forming a coordinated chemical bond to fix it in the wood component.
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Prasad, Pramod. "A Beacon for Gynaecological Cancers Patients: pH-Sensitive Nano medicine." Obstetrics Gynecology and Reproductive Sciences 4, no. 1 (January 23, 2020): 01–10. http://dx.doi.org/10.31579/2578-8965/035.

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Emergence of various Nano scale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine. Nonetheless, the side-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remain to be a prime pitfall in curing cancers. Therefore, to achieve a better therapeutic efficacy, the use of a target-specific delivery, combined with a stimuli-responsive Nano carrier system, particularly pH-sensitive Nano systems offer an attractive strategy. Targeted drug delivery through pH-sensitive Nano systems offer the potential to enhance the therapeutic index of anticancer agents, either by increasing the drug concentration in tumour cells and/or by decreasing the exposure in normal host tissues. Therefore, Nano scale-based drug delivery through pH-sensitive Nano systems seem to be a boon for treating gynaecological cancers (as well as other cancers) without side-effects or with least harm to normal healthy tissues.
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Sharma, Manish Kumar, and Rashmi Gupta. "Nanorobotics: The Future of Medicines." Research in Pharmacy and Health Sciences 2, no. 1 (February 15, 2016): 51–56. http://dx.doi.org/10.32463/rphs.2016.v02i01.10.

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Nano-robots are the technology of creating machines or robots close to the microscopic scale to nanometer. Nano-robots is a truly multidisciplinary field which comprises of the simultaneous advantage of medicinal and robots knowledge disciplines will merge including robots, and mechanical, chemical and biomedical engineering, chemistry, biology, physical science and mathematics or arithmetic. Nano-robots medicine is therapeutically more effective, individualized, dose reduced and more affordable medicine. Nano-robots medicines are being developed to improve drug bioavailability. Target drug delivery is currently the most advanced application of Nano-robots in medicine. Nanotechnology is being used to produce new generations of biomaterial scaffolds that can encourage or support cell growth and differentiation into often complex tissue types. Nano-robots medicine include targeting semi-metallic or metallic nanoparticles, e.g. silica, iron or gold, to tumor sites and then activating them by external means, e.g. light, magnetic field, ultrasound, to produce heat or soft radiation locally that can destroy the cancer cells in situ gene therapy cell therapy. Nano medicines are better imaging-techniques and other diagnostic tools Nano-robots opens up new ways for vast and abundant research work in which many. Nanorobots have strong potential to revolutionize healthcare to treat disease in future.
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Kulkarni, Santosh S. "BHASMA AND NANO MEDICINE." International Research Journal of Pharmacy 4, no. 4 (November 21, 2016): 10–16. http://dx.doi.org/10.7897/2230-8407.04402.

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Marchesan, Silvia, and Maurizio Prato. "Nanomaterials for (Nano)medicine." ACS Medicinal Chemistry Letters 4, no. 2 (December 11, 2012): 147–49. http://dx.doi.org/10.1021/ml3003742.

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Hasanzadeh-Kiabi, Farshad. "Nano-drug for Pain Medicine." Drug Research 68, no. 05 (November 3, 2017): 245–49. http://dx.doi.org/10.1055/s-0043-120661.

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AbstractPain is commonly categorized into two diverse groups: acute pain, characterized by early onset and last for a very short time; while chronic pain, characterized by a prolonged pain for least 3 months’ duration. Timely and immediate management of critical pain is critical in reducing its aggravation to chronic pain. There has been successful application of nano-technology, nano-medicine to the treatment and management of pain both in clinical and experimental studies like the fabrication of nano-formulated liposomes to deliver drugs for pain therapy, formulation of non- steroidal anti-inflammatory drugs (NSAIDs). However safety issues related with NSAIDs have impelled the fabrication and the design of new drug formulations that reduces side effects and sustain efficacy. This review will give a concise summary on the available studies on the application of nano-formulated drugs designed for pain treatment and management.
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Bell, Iris R. "The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease." Homeopathy 109, no. 02 (November 30, 2019): 051–64. http://dx.doi.org/10.1055/s-0039-1694999.

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Abstract Background Evidence indicates that homeopathic medicines are complex self-organizing nano-scale systems that generate unique low-intensity electromagnetic signals and/or quantum coherence domains. In Part 1, we reviewed relevant concepts from complex adaptive systems science on living systems for the nature of homeopathic healing. Aim In Part 2, we discuss the complex-system nature of homeopathic medicines. The aim is to relate the evidence on the nature and properties of homeopathic medicines to the complex systems model for homeopathic healing. Methods and Results The work is a narrative review, with complexity model development for the nature of homeopathic medicines. Studies suggest that homeopathic manufacturing generates nano-structures of source material, silica and silicon quantum dots if succussed in glassware or including botanical source materials; or carbon quantum dots if succussed in plastic or including any organic source materials, as well as solute-induced water nano-structures carrying medicine-specific information. On contact with physiological fluids (e.g., blood plasma), there is evidence that nano-structures additionally adsorb individualized patterns of the recipient's own proteins on to their surfaces to create a unique protein corona coat (shell). Thus, the simillimum may generate a personalized biological identity upon administration. Consequently, a medicine can serve as an individually salient, self-similar information carrier, whose protein corona constituent pattern reflects the individual's current internal state of health/disease. Homeopathic medicine complexity emerges from interactions of the component parts from source, silica from glassware or carbon from plastic containers, solvents (lactose, water, ethanol), adsorbed biomolecule layers from plant or animal sources, and adsorbed biomolecules of the recipient. Low doses of these complex medicines can act as biological signaling agents to initiate hormesis via a network-wide pattern of adaptive responses by the recipient complex adaptive system, rather than as conventional pharmaceutical drugs. Biological mediators of adaptive responses include inter-connected network elements of the cell danger/damage defense system: for example, gene expression, reactive oxygen species, heat shock proteins, cytokines, macrophages, T-cells, and associated brain–immune system mediator pathways. Conclusions Every homeopathic medicine is a complex nano-scale system involving multiple inter-connected, interacting components, and emergent properties. Simillimum individualization derives from formation of a unique personalized protein corona shell adsorbed to the reactive surface of the homeopathic nano-structures on contact with the recipient's body fluids. Low doses of such complex nano-structures initiate the adaptive processes of hormesis to mobilize endogenous healing of a disease state. The capacity for self-organization and self-similarity in complex systems is the key to future research on the nature of homeopathic medicines and systemic healing during individualized homeopathic treatment.
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Xie, Maobin, Di Wu, Guangmeng Li, Jingbo Yang, and Yu Shrike Zhang. "Exosomes targeted towards applications in regenerative medicine." Nano Select 2, no. 5 (January 23, 2021): 880–908. http://dx.doi.org/10.1002/nano.202000251.

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Choi, Bogyu, and Soo-Hong Lee. "Nano/Micro-Assisted Regenerative Medicine." International Journal of Molecular Sciences 19, no. 8 (July 26, 2018): 2187. http://dx.doi.org/10.3390/ijms19082187.

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Dissertations / Theses on the topic "Nano medicine"

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Feil, Florian. "Single molecule diffusion studies in nanoporous systems: From fundamental concepts to material science and nano-medicine." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-144120.

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André, Emilie. "Combination of nano and microcarriers for stem cell therapy of Huntington's disease : new regenerative medicine strategy." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0047/document.

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La combinaison de biomatériaux et cellules souches, a pour but de protéger des cellules endommagées et de ralentir la progression des maladies neurodégénératives, comme la maladie de Huntington (MH). Les cellules souches mésenchymateuses et particulièrement une sous-population, les cellules MIAMI, ont déjà démontré leur efficacité dans la maladie de Parkinson. Il est cependant essentiel d’améliorer leur différenciation neuronale, leur survie et évaluer leur sécrétome. L’objectif principal de ce travail fut de proposer une stratégie innovante de médecine régénératrice pour la MH associant cellules souches, nano et micro médecines. Pour l’évaluer, un nouveau modèle animale ex vivo de la MH a été mis en place. Nous avons ensuite développé et optimisé deux nano-vecteurs, des nanocapsules lipidiques et des nanoparticules solides de SPAN, et les avons associés à un inhibiteur de REST qui est un facteur de transcription qui empêche la différenciation neuronale. La transfection de ce siREST a montré une amélioration du phénotype neuronal. Ces cellules ainsi modifiées furent ensuite induites vers un phénotype GABAergic grâce à des facteurs de croissance. Puis elles ont été associées à un support 3D, les microcarriers pharmacologiquement actif (MPA) permettant une meilleure intégration des cellules après greffe. Les MPA sont des microsphères ayant une surface biomimétique de laminine et libérant de façon contrôlée un facteur trophique le « brain derived neurotrophic factor » (inducteur d’un phénotype neuronal et neuro-protecteur). Des résultats prometteurs ont été obtenus, encourageant à continuer l’évaluation de cette stratégie in vivo dans des modèles génétiques de la MH
The combination of biomaterials and stem cells aims to protect damaged cells and slow the progression of neurodegenerative diseases such as Huntington's disease(HD). Mesenchymal stem cells, particularly a subpopulation known as MIAMI cells, have already demonstrated their effectiveness in Parkinson's disease. However, it is essential to improve their neuronal differentiation, survival, and to assess their secretome. The main objective of this work was to propose an innovative regenerative medicine strategy for HD by combining stemcells, micro and nano medicines. To perform this assessment, a new ex vivo animal model of HD has been set up. We then developed and optimized two nanovectors,lipid nanocapsules and solid SPAN nanoparticles,carrying an inhibitor of REST a transcription factor, which prevents neuronal differentiation. The transfection of this siREST showed an improvement in the neuronal phenotype. These modified cells were then induced into a GABAergic phenotype through growth factors. They were then associated with a 3D support, the pharmacologically active microcarriers (PAM) allowing a high rate of engraftment. The PAM are microspheres which have a biomimetic surface of laminin and release a trophic factor BDNF, brain derived neurotrophic factor (inducer of a neural phenotype and neuroprotective) in a controlled manner. Promising results were obtained, further encouraging continuing the evaluation of this strategy in vivo in genetic models of HD
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Memarzadeh, Kaveh. "Investigations into the use of nano-based antimicrobial and osteoconductive coatings for bone implants." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9001.

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Objectives: Orthopaedic and dental implants are prone to frequent infections. This can lead to detrimental and often irreversible outcomes for many patients. The objective of this study was to develop a novel system using zinc oxide nanoparticles (nZnO) as a coating material that inhibits both bacterial adhesion / growth and promotes osteoblast growth. Methods and Results: Initially bacteria (S. aureus, E. coli, S. epidermidis and P. aeruginosa) were exposed to different concentrations of zinc oxide nanoparticulate suspensions (250 μg/mL, 500 μg/mL, 1000 μg/mL and 2500 μg/mL); with the higher concentrations of the suspensions demonstrating significant bactericidal effects. A novel electrohydrodynamic atomization coating technique (EHDA) was used to deposit mixtures of nZnO and nano-hydroxyapatite (nHA) onto the surface of glass samples (1 cm2). Exposure of the coated samples to phosphate buffered saline (PBS) and adult bovine serum (ABS) and measurement of bactericidal activity demonstrated superior antimicrobial activity for 100% and 75% nZnO composite coated samples. Lactate dehydrogenase (LDH) release from osteoblast-like cells (UMR-106 and MG-63) exposed to both nano-TiO2 and nano-ZnO nanoparticulate suspension supernatants indicated minimal toxicity. Nano-ZnO coated samples did not elicit LDH release with an increase in proliferation and viability of cells was observed. Scanning electron microscopy (SEM) and optical microscopy indicated that all cell types used (mesenchymal stem cells and osteoblast-like cells) were able to maintain their normal morphological state when adhered to the surface of the nano-coated material. Further studies as regards to patterned coated samples showed an exclusive adhesion selection by osteoblast-like cells to nZnO patterned regions that needs to be further investigated. Conclusion: ZnO NPs provide an antimicrobial and biocompatible coating material for medical and dental bone implants.
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Xu, Zizhao. "Development of Lipid-based Nano Formulations of Miriplatin Against Lung Cancer." Scholarly Commons, 2020. https://scholarlycommons.pacific.edu/uop_etds/3699.

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Cancer is the second leading cause of death and is responsible for approximately 9.6 million deaths worldwide in 2018. Among all oncological diseases, lung cancer claims the highest mortality (male: 23.5%; female: 22%) and the second most new cases (male: 13%; female: 12%) in the US. Approximately 40% of newly diagnosed lung cancer patients are in the advanced stage IV, for which platinum-based chemotherapy is the first-line treatment, either by itself or in combination with surgery or radiotherapy. Cisplatin, the first-generation platinum-based anticancer chemotherapeutic agent, has the highest potency against lung cancer but carries many severe adverse effects. Cisplatin also induces drug resistance during long-term chemotherapy. Many more platinum complexes have been investigated as better alternatives, which led to the approval of carboplatin and oxaliplatin by Food and Drug Administration (FDA). In addition, miriplatin suspended in iodolipds (lipiodolization) was approved in Japan for the treatment of hepatocellular carcinoma (HCC) in 2009. Miriplatin has the same non-leaving group as oxaliplatin but different leaving groups of two myristate chains, which make it highly lipophilic. Several characteristics of solid tumors in lung cancer constitute a physiochemical barrier to the homogenous distribution and deep penetration of chemotherapy agents. Nanocarriers provide a promising platform to overcome the physiochemical barrier and to reduce the systemic toxicity of anticancer chemotherapy. In this study, miriplatin is formulated with various lipid-based nanocarriers including micelles and solid lipid nanoparticles (SLNs) thanks to its highly lipophilic structure. The goal of this thesis is to develop and evaluate miriplatin-loaded nano formulations against lung cancer. Miriplatin-loaded formulations were prepared by different methods, including thin film hydration and several scale-up methods including chloroform dripping, chloroform injection, chloroform evaporation, co-solvent evaporation, chloroform slow evaporation and co-solvent slow evaporation. Between the two types of nano formulations under this study, micelles were much smaller (~10 nm in diameter) and more homogeneous (PDI < 0.3), while SLNs were bigger (~ 100 nm in diameter) and more heterogeneous (PDI ~0.8). A quantification method of miriplatin was established using inductively coupled plasma-optical emission spectrometry (ICP-OES). The quantification of platinum recovery from different miriplatin-loaded nano formulations was facilitated by digestion with 70% nitric acid and heating. The co-solvent slow evaporation method to prepare miriplatin-loaded nano formulations improved the platinum recovery prominently from 10% to 70%. Thus, co-solvent slow evaporation has been established as a pharmaceutically viable scale-up method to prepare nano formulations of miriplatin. Miriplatin-loaded nano formulations of different compositions were negatively stained with uranyl acetate and then imaged by transmission electron microscopy (TEM), which showed the formulations’ size and morphology that were consistent with the size and PDI data from dynamic light scattering studies by the Malvern Zetasizer. In the TEM studies, micelles showed a morphology of spherical dots at around 10 nm in diameter while SLNs showed both spherical and rod structures with a size distribution from 50 to 150 nm. A three-dimensional multicellular spheroid (3D MCS) model of A549-iRFP cells was used for in vitro evaluation of the nano formulations’ activity against lung cancer. A549-iRFP cells were engineered from the common lung cancer cell line A549 to stably express the near-infrared fluorescent protein (iRFP). The viability of A549-iRFP 3D MCS after exposure to cisplatin or nano formulations was similar to A549 3D MCS. The anticancer activity of miriplatin-loaded nano formulations against 3D MCS was positively associated with the platinum recovery as quantified by ICP-OES. The miriplatin-loaded nano formulations that had been prepared by the co-solvent slow evaporation method showed substantial anticancer activities against A549 3D MCS and A549-iRFP 3D MCS, which were comparable to cisplatin. Taken together, miriplatin-loaded nano formulations were successfully prepared by co-solvent slow evaporation. The formulations were developed to carry favorable physiochemical properties to enhance the activities of platinum drugs against lung cancer.
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Feil, Florian [Verfasser], and Christoph [Akademischer Betreuer] Bräuchle. "Single molecule diffusion studies in nanoporous systems: From fundamental concepts to material science and nano-medicine / Florian Feil. Betreuer: Christoph Bräuchle." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1023435489/34.

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Fornaguera, Puigvert Cristina. "Development of multifunctional polymeric nanoparticles by nano-emulsion templating as advanced nanocarriers targeting the blood-brain barrier." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/285368.

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Multifunctional polymeric nanoparticles (NP) represent a promising alternative for the treatment of neurodegenerative diseases using the intravenous route (i.v.). In current treatments, the effects of the intravenously injected drugs are systemic, requiring high drug doses to achieve therapeutic effects, thus causing severe side effects. NP can act specifically in a tissue provided that they are properly designed. An interesting approach is the preparation of NPs by nano-emulsion templating. Nano-emulsions (NE) are fine emulsions, with droplet sizes typically between 20 – 200nm. They can be prepared by the phase inversion composition (PIC) method, a low-energy emulsification method appropriate for pharmaceutical applications, since it can be performed at mild process conditions. Nanoparticles are obtained from nano-emulsions by solvent evaporation. To target the central nervous system (CNS), a specific targeting moiety on the nanoparticle surface is required to cross the blood-brain barrier (BBB), which is a current key goal under intense investigations. The aim of this work was to obtain multifunctional polymeric NP as advanced delivery systems able to cross the BBB. O/W polymeric NE were prepared by the PIC method and polymeric NPs were obtained by solvent evaporation. Polymeric NP with appropriate sizes for the i.v. administration (<1milimicron) were obtained. With the aim to design imaging systems, a model fluorescent dye and magnetic nanoparticles were encapsulated in polymeric NPs. An analgesic and an antiapoptotic drugs were also encapsulated into PLGA NP for therapeutic purposes. High encapsulation efficiencies were found for all tested compounds, attributed to the method of nanoparticle preparation as well as to low solubility of the components in the aqueous dispersion media. In addition, a sustained and controlled release of fluorescent dyes / drugs was achieved. NP surface was functionalized using various elements. On the one hand, it was functionalized with a monoclonal antibody against the transferring receptor, overexpressed in the BBB, to achieve an active targeting to the BBB. On the other hand, NPs were functionalized with oligonucleotides, to be used as non-viral gene delivery systems. Firstly, carbosilane cationic dendrons were covalently attached to nanoparticle surface to achieve a cationic surface. In a further step, antisense oligonucleotides, siRNA and plasmids were electrostatically bound to cationized nanoparticles. In vitro tests showed that the formulated NP did produce neither cytoxicity nor hemolysis. In addition, they were weak activators of the immune system and produced only a slight adsorption of blood proteins. Therefore, they are appropriate to be used by the i.v. route. NPs functionalized with oligonucleotides enhanced gene transfection in cell cultures, up to values comparable to those of commercial values (up to 90%). These NPs are advantageous in terms of toxicity issues over the commercial formulations. Therefore, they represent promising non-viral gene delivery systems. In vivo tests, which measured the central analgesia produced by an encapsulated drug into nanoparticles (loperamide) that is not able to cross the BBB, confirmed a central analgesic effect, reaching a potency of analgesia comparable to positive controls when nanoparticles were functionalized with the antibody. Therefore, the antibody functionalized nanoparticles efficiently crossed the BBB. In conclusion, the designed polymeric nanoparticles, functionalized with the antitransferrin receptor antibody, are able to cross the BBB with high efficiency. These nanoparticles represent promising nanosystems to deliver actives to the central nervous system.
Les nanopartícules polimèriques multifuncionals (NPs) representen una alternativa prometedora pel tractament de malalties neurodegeneratives, a través de l’administració intravenosa (i.v.), ja que els tractaments actuals provoquen molts efectes secundaris. Les NPs, en canvi, si estan correctament dissenyades, poden actuar específicament en el teixit diana. Ja que l’òrgan diana és el cervell, és necessari un element de vectorització per poder creuar la barrera hemato-encefàlica (BBB). En aquest context, l’objectiu de la present tesi és l’obtenció de NPs com a sistemes avançats d’alliberament de principis actius que travessin la BBB. Es van obtenir NPs a partir de nano-emulsions (NE) plantilla, emprant l’àcid poli-(làctic-co-glicòlic) com a polímer i el mètode d’inversió de fases a temperatura constant per emulsionar, seguit d’evaporació de solvent per obtenir NPs. Les NPs obtingudes tenen mides apropiades per l’administració i.v.. Es va aconseguir encapsular un fluorescent i NPs magnètiques dins les NPs polimèriques, per fer-les servir com a sistemes d’imatge. També es van encapsular fàrmacs per usar-les com a sistemes terapèutics. En tots els casos, es van aconseguir eficiències d’encapsulació molt elevades i un alliberament del fàrmac controlat i prolongat en el temps. A més, es va aconseguir funcionalitzar la superfície de les NPs amb diferents elements. Es van unir covalentment dendrons catiònics per posteriorment unir oligonucleòtids electrostàticament. També es va afegir una coberta exterior de polietilenglicol per protegir el material genètic. Per altra banda, es va funcionalitzar la superfície de les NPs amb un anticòs específic contra el receptor de la transferrina, sobreexpressat a la BBB. A continuació, es van fer assajos in vitro, que van posar de manifest que les NPs no són citotòxiques ni hemolítiques. També es va estudiar l’eficiència de transfecció cel•lular del material genètic, arribant a eficiències de transfecció equivalents a les dels vectors comercials. Assajos in vivo van permetre confirmar el pas a través de la BBB, sobretot de les NPs funcionalitzades amb l’anticòs. Els resultats obtinguts permeten concloure que s’ha aconseguit dissenyar noves NPs polimèriques a partir de NE, apropiades per l’administració i.v. i amb capacitat de travessar la BBB.
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Jayasinghe, Chaminda. "Synthesis and Characterization of Carbon Nanotube, Threads, Yarns, and Sheets." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1312292744.

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Pearson, Frances E. "Transcutaneous delivery of T cell-inducing viral vector malaria vaccines by microneedle patches." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:2155c639-bcc8-49e0-b415-a5d353aacba3.

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There is an urgent need for improvements to existing vaccine delivery technologies to run parallel with the development of new-generation vaccines. The burdens of needle-based immunisation strategies are exacerbated by poor resource provision in such areas as sub-Saharan Africa, where annual malaria mortality stands at 860,000. Needle-free delivery of vaccine to the skin holds promise for improved immunogenicity with lower doses of vaccine, in addition to significant logistical advantages. Various methods have been described for the transcutaneous delivery of vaccines, including the use of microneedles to overcome the outer stratum corneum of the skin for efficient delivery of liquid or solid, microneedle-coated vaccines into underlying strata rich in antigen-presenting cells. This thesis aims to evaluate two transcutaneous silicon microneedle and microprojection patch technologies for the delivery of live recombinant Adenovirus and Modified Vaccinia Ankara-vectored vaccines encoding pre-erythrocytic malaria antigens in mice. Cellular immunogenicity directed against a well-documented epitope of the Plasmodium berghei circumsporozoite protein is evaluated, as is protection against lethal P. berghei sporozoite challenge. Immunological and logistical benefits of each technology are assessed, as well as mechanisms underlying differences in the generation of a patch-induced immune response to vaccination. These data inform the future development of transcutaneous microneedle patches for the delivery of live vaccine.
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Bachtarzi, Houria. "Targeting polymer coated adenovirus to tumour-associated vasculature." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:602123e8-814c-4b63-a482-ab8adcfa6594.

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Tumour-associated vasculature provides an accessible target for systemic gene therapy using targeted adenoviruses. The aim of this thesis is to develop strategies for targeting adenovirus infection to tumour-associated endothelium. Adenovirus expressing luciferase (Adluc) was coated with an amino-reactive polymer based on poly [N-(2-hydroxypropyl) methacrylamide] [pHPMA] to ablate normal infection pathways¬. This was a pre-requisite to redirecting virus tropism to infect endothelial cells via specific receptors. Direct attachment to the pHPMA-adenovirus (pcAdluc) of ligands including vascular endothelial growth factor (VEGF165) and a monoclonal antibody (RAFL) recognising VEGF receptor 2 (VEGFR-2) retargeted infectivity to VEGFR-2-positive endothelial cells and not to receptor-negative cells. Specificity of transduction in vitro was shown by competition with excess antibody. In vivo however, the VEGF165-retargeted virus failed to transduce tumour-associated endothelia following systemic administration. Similarly, direct linkage of a monoclonal antibody against E-Selectin (MHES) demonstrated E-Selectin-specific transduction of tumour necrosis factor-α (TNF-α)-activated endothelial cells, although overall levels of infection were not increased compared to unmodified Adluc. A two-component targeting system using protein A or protein G as ‘bridging’ agents was developed to ensure the required orientation of targeting antibodies. Using this system MHES mediated greater transduction of TNF-α-activated endothelial cells than Adluc. Conjugation using protein A also gave non-specific effects which were not seen with protein G. Whereas the unmodified Adluc virus failed to transduce TNF-α-activated endothelium in an umbilical vein model ex vivo, the MHES-protein G-pHPMA-adenovirus (MHES-StrepGpcAdluc) mediated good transduction. Similarly, StrepGpcAdluc retargeted with a chimeric P-Selectin Glycoprotein Ligand-1 (PSGL-1)-Fc fusion protein, showed good circulation kinetics and significant uptake into HepG2 xenografts following intravenous administration. Histological studies suggested selective targeting to tumour-associated endothelial cells. Overall these findings support the assertion that tumour-associated vasculature is an accessible target for systemic gene delivery, and the use of protein G as bridging agent facilitates rapid screening of Fc-bearing ligands for retargeting pcAd infection to tumour-associated endothelium.
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Brisola, Gabriel Motta Pinheiro. "Efeitos da suplementação de β-alanina sobre a potência anaeróbia, habilidade de esforços repetidos e desempenho no polo aquático /." Rio Claro, 2016. http://hdl.handle.net/11449/144686.

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Orientador: Alessandro Moura Zagatto
Banca: Marcelo Papoti
Banca: Guilherme Giannini Artioli
Resumo: O objetivo geral do presente trabalho foi verificar o potencial ergogênico da suplementação por 4 semanas de β-alanina sobre a potência anaeróbia, habilidade de esforços repetidos e desempenho no polo aquático. 22 jogadores de elite do sexo masculino (média±dp: idade = 18±4 anos, peso = 78,5±9,5 kg e altura = 1,79±0,06 m) participaram do estudo, que foi conduzido de modo randomizado, duplo cego e placebo controlado. Os participantes foram divididos em dois grupos (β-alanina e placebo) de 11 atletas cada e foram submetidos a testes específicos (teste de habilidade de esforços repetidos (RSA) e teste máximo de 30s de salto sob o gol (30CJ)) e semi-específicos (teste de 30s máximo em nado atado (30ATADO), teste máximo de 3 minutos (All Out 3min), teste incremental máximo (GXTATADO) e performance de 200m em nado crawl (P200m)) para a modalidade e um jogo simulado para possibilitar o rastreamento das atividades realizadas por meio de filmagem. As avaliações ocorreram pré e após o período de suplementação (4 semanas). Não foram encontrados efeitos significativos de interação entre os grupos para nenhuma variável do presente estudo. No entanto, alguns ligeiros indícios de melhora com a suplementação de β-alanina foram encontrados como: (1) melhora significativa entre os momentos (pré × pós) no número total de sprints durante o jogo simulado de polo aquático; (2) efeito provavelmente benéfico (análise de inferência baseada na magnitude) para o tempo médio, pior tempo e tempo total na... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The overall aim of this study was to investigate the ergogenic effect of 4 weeks β-alanine supplementation on the anaerobic power, ability to performed repeated efforts and performance of water polo. 22 male elite players (mean±SD age = 18±4 years, weight = 78.5±9.5 kg and height = 1.79±0.06 m) participated in the study, which was conducted in order randomized, double blind and placebo controlled. Participants were divided into two groups (β-alanine and placebo) of 11 athletes each and were subjected to specific tests (repeated sprint ability test (RSA) and maximum 30s jump under the goal test (30CJ)) and semi-specific (30s maximal test in tethered swimming (30TS), maximal 3 min effort (AllOut-3min), tethered swimming graded exercise test (GXTTS) and 200m in front crawl (P200m)) for the modality and a simulated game to enable tracking of the activities carried out by video record. Assessments occurred before and after the supplementation period (4 weeks). There were no significant interaction effects between the groups for any variable of this study. However, some slight improvement indications with β-alanine supplementation were found to: (1) significant improvement between moments (pre × post) the total number of sprints during the simulated game water polo; (2) probably beneficial effect (magnitude-based inference analysis) for the mean time, worst time and total time in the first series of the RSA test (RSA1); (3) significant improvement between moments for mean force and integral of force during the 30TS and P200m; (4) significant improvement between moments for peak power at GXTTS. Therefore, it is concluded that supplementation for 4 weeks of β-alanine can promote only slightly improve some parameters related to swimming ability in water polo as total number of sprints in simulated game, mean time,... Complete abstract electronic access below)
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Books on the topic "Nano medicine"

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Das, Malay K., and Yashwant V. Pathak, eds. Nano Medicine and Nano Safety. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6.

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Robin, Cook. Nano. New York: G.P. Putnam's Sons, 2012.

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Robin, Cook. Nano. New York: Berkley Books, 2013.

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Robin, Cook. Nano. New York: G. P. Putnam's Sons, 2012.

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Robin, Cook. Nano: Roman. Paris: Le Livre de poche, 2015.

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Endō, Isao. Nano/Micro Biotechnology. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2010.

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Fonash, Stephen, and Marcel Van de Voorde. Engineering, Medicine and Science at the Nano-Scale. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2018. http://dx.doi.org/10.1002/9783527692903.

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Tissue engineering and regenerative medicine: A nano approach. Boca Raton: CRC Press, 2013.

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Polymers in regenerative medicine: Biomedical applications from nano- to macro-structures. Hoboken, New Jersey: Wiley, 2015.

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Collins, Michael W. Micro and Nano Flow Systems for Bioanalysis. New York, NY: Springer New York, 2013.

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Book chapters on the topic "Nano medicine"

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Deka, Trinayan, Malay K. Das, Sanjoy Das, L. Ronibala Singha, and Punamjyoti Das. "Nanobiotechnology and Its Application in Nanomedicine: An Overview." In Nano Medicine and Nano Safety, 3–25. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_1.

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Ray, Subhabrata, Sayani Bhattacharyya, Parthasarathi Panda, Awantika Pandey, and Kajal Ghosal. "Advances in Pulmonary Nanomedicine for Therapeutic Management of Respiratory Diseases." In Nano Medicine and Nano Safety, 237–66. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_10.

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Hazarika, Hemanga, Harshita Krishnatreyya, Pronobesh Chattopadhyay, Achintya Saha, Yashwant V. Pathak, and Md Kamaruz Zaman. "Nanoemulsion Delivery of Herbal Products: Prospects and Challenges." In Nano Medicine and Nano Safety, 267–88. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_11.

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Tripathy, Surendra, Roohi Kesharwani, Dilip Kumar Patel, and Malay K. Das. "Stimuli-Responsive Polymers for Cancer Nanomedicines." In Nano Medicine and Nano Safety, 289–311. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_12.

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Can, Mehmet, and Nurettin Sahiner. "Carbohydrate-Derived Tailorable Interfaces: Recent Advances and Applications." In Nano Medicine and Nano Safety, 313–46. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_13.

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Sahu, Bhanu P., Nikhil Biswas, and Malay K. Das. "Multifunctional Nanoscale Particles for Theranostic Application in Healthcare." In Nano Medicine and Nano Safety, 347–75. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_14.

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Sarma, Anupam, Malay K. Das, and Tapash Chakraborty. "Ligand Nanoparticle Conjugation Approach for Targeted Cancer Chemotherapy." In Nano Medicine and Nano Safety, 377–403. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_15.

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Suner, Selin S., Betul Ari, Sahin Demirci, and Nurettin Sahiner. "Tunable Biopolymeric Drug Carrier Nanovehicles and Their Safety." In Nano Medicine and Nano Safety, 405–32. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_16.

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Mehta, Tejal, Heena V. Dave, Jigna Shah, Kartik Hariharan, Humera Memon, Molisha Soni, and Jennifer Johnson. "Nanomedicine for Challenging Solid Tumors: Recent Trends and Future Ahead." In Nano Medicine and Nano Safety, 433–65. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_17.

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Mukherjee, Biswajit, Debasmita Dutta, Prasanta Ghosh, Brahamacharry Paul, Ramkrishna Sen, and Samrat Chakraborty. "Recent Trends for Nanomedicine Safety." In Nano Medicine and Nano Safety, 469–509. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6255-6_18.

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Conference papers on the topic "Nano medicine"

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Jakobsson, Eric, May D. Wang, and Linda Molnar. "Bio-Nano-Info Integration for Personalized Medicine." In 2007 IEEE 7th International Symposium on BioInformatics and BioEngineering. IEEE, 2007. http://dx.doi.org/10.1109/bibe.2007.4375770.

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Park, Dong Kyun, Eun Young Jung, and Byung Chan Moon. "The evolution of telemedicine and nano-technology." In SPIE Nanosystems in Engineering + Medicine, edited by Sang H. Choi, Jin-Ho Choy, Uhn Lee, and Vijay K. Varadan. SPIE, 2012. http://dx.doi.org/10.1117/12.2000532.

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Arai, Fumihito. "Micro-/nano- robotic manipulation and biomedical applications." In SPIE Nanosystems in Engineering + Medicine, edited by Sang H. Choi, Jin-Ho Choy, Uhn Lee, and Vijay K. Varadan. SPIE, 2012. http://dx.doi.org/10.1117/12.1000010.

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Darr, J. A. "Nano- and biomaterials using supercritical fluids technologies." In IEE Seminar on MNT in Medicine. IEE, 2004. http://dx.doi.org/10.1049/ic:20040586.

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Varadan, Vijay K. "Wearable and mobile healthcare nanosystems and their applications in medicine." In Nano-, Bio-, Info-Tech Sensors and Wearable Systems, edited by Jaehwan Kim. SPIE, 2021. http://dx.doi.org/10.1117/12.2584159.

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Pierstorff, Erik, Max Krucoff, and Dean Ho. "Multitherapeutic hybrid material platforms for nanoengineered medicine." In 2008 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, 2008. http://dx.doi.org/10.1109/nems.2008.4484515.

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Bulnes, Francisco, Francisco H. Bulnes, Eduardo Herna´ndez, and Juan Maya. "Integral Medicine: Cure and Organic Regeneration to Nano-Metric Level by Quantum Medicine Methods Programming Path Integrals." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-64743.

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In the last years into the alternative medicine, have arise methods into the context of the quantum medicine and the generalization of the homeopathic methods that establish principles of holistic and causal cure in a deep level of cure, correcting and restoring the conscience of cure of the proper body. In this work that is the recompilation of some important results published, it considers and develops quantum methods of cure and organic re-generation, realizing actions of restoration and alignment of the vital field and their programming by means of intelligence codes of cure by path integrals.
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Ferrati, Silvia, Rita E. Serda, Andrew Bean, and Mauro Ferrari. "Intracellular Trafficking of Nano-Carriers." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13303.

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A multistage delivery system based on biodegradable mesoporous silicon particles loaded with one or multiple second stage nano-particles is likely to be useful for drug delivery. Upon intravenous injection the silicon nano-carriers will travel through the blood stream and migrate to the vessel wall. Vascular endothelial cells have been shown to be promising candidates for drug delivery as they represent both an anchor point and target.[1] It has been shown that human endothelial cells can act as nonprofessional phagocytes internalizing our silicon micron-sized nano-carriers.[2] The complete understanding of the molecular mechanisms required for the internalization of the particles into cells, as well as their fate once internalized, is crucial for the choice and formulation of appropriate second stage particles to be loaded in the silicon carrier. For example, different types of coatings or functionalization for both silicon nano-carriers and nano-particles could favor different trafficking pathways or promote endosomal escape following cellular uptake. In this study the uptake and trafficking of silicon nano-carriers in Human Microvascular Vein Endothelia Cells (HMVECs) was monitored using TEM, confocal microscopy and immunofluorescence.
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Kapadia, Vishal, Houjin Huang, Erik Pierstorff, Mark Chen, and Dean Ho. "Magneto-therapeutic functionalized carbon nanoparticles for interrogative medicine." In 2008 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, 2008. http://dx.doi.org/10.1109/nems.2008.4484514.

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Wang, Yipei, Yunbo Liu, Xintao Zhao, and Somin E. Lee. "High-speed nano-polarimetry for real-time plasmonic bio-imaging." In Plasmonics in Biology and Medicine XV, edited by Tuan Vo-Dinh and Joseph R. Lakowicz. SPIE, 2018. http://dx.doi.org/10.1117/12.2289144.

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