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Dissertations / Theses on the topic 'Nanobody'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kent, Lisa. "Targeting the N-myc oncoprotein using nanobody technology." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278020.

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The myc family of oncogenic transcription factors, which includes c-myc, N-myc and L-myc, control major cellular processes such as proliferation and differentiation by integrating upstream signals and orchestrating global gene transcription. They do this largely through dimerising with Max, which together bind to enhancer (E)-box elements in DNA. Myc proteins function similarly but differ in potency and tissue distribution. For instance, N-myc is expressed predominantly during development in undifferentiated cells of the nervous system, whereas c-myc is ubiquitously expressed in all proliferat

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2

Hoff, Merle [Verfasser]. "Kombinatorische Analyse von Nanobody-markierten Epitopen zur Proteinbestimmung / Merle Hoff." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/122862383X/34.

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3

Taylor, Edward John Robert. "Synthesis and characterisation of peptide-based probes for quantitative multicolour STORM imaging." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284553.

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Current single molecule localisation microscopy methods allow for multicolour imaging of macromolecules in cells, and for a degree quantification on molecule numbers in one colour. However, that has not yet been an attempt to develop tools capable of quantitative imaging with multiple colours in cells. This work addressed this challenge by designing linker peptides with chemospecific groups to allow attachment of activator and emitter dyes for STORM imaging, and a targeting module. The design ensured a stoichiometric ratio of targeting module to activator and emitter dyes. Peptides with HaloTa

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4

CAPALDO, PIETRO. "Capacitance immunosensors for the early detection of circulating cancer biomarkers." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908095.

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I have been successful in improving and developing a homemade device based on a three-electrodes electrochemical redout setup thanks to it, we are able to perform measurements of DNA-hybridization, in real-time, from probe ssDNA-SAMs coupled to gold coated sensor surfaces. The measurements were carried out, in pure saline buffer solution, on a large range of concentrations of complementary-DNA strands (from 1 pM to 100 nM), monitoring the differential capacitance at the Working Electrode versus the incubation time. The studies on kinetics, modeled using the Langmuir adsorption model, not only

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5

Peyrassol, Xavier. "Développement et caractérisation d’anticorps de camélidés dirigés contre des récepteurs couplés aux protéines G et leur utilisation dans des approches structurales." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/270870.

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Les camélidés possèdent une caractéristique immunologique particulière parmi les mammifères. En plus des anticorps conventionnels tétramériques composés de 2 chaînes lourdes et de 2 chaînes légères, on retrouve dans des proportions variant de 25 à 50% des anticorps dépourvus de chaînes légères. Le paratope de ces anticorps est dès lors constitué de la partie variable monomérique des chaînes lourdes. Ce domaine d’environ 15 kDa représente le plus petit fragment capable de lier un antigène et est communément appelé nanobody de par sa petite taille. Les nanobodies possèdent des propriétés uniques

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6

Hajj, Sleiman Nawal. "Approche par nanobody pour capturer les interactomes de complexes protéiques dimériques en contexte cellulaire vivant." Electronic Thesis or Diss., Lyon, École normale supérieure, 2024. http://www.theses.fr/2024ENSL0041.

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L’identité et le devenir de chaque cellule dépend du contenu en protéines et, en particulier, des réseaux d'interactions protéine-protéine (IPP, également appelés interactomes). Les protéines ont la propriété générale de s'engager dans des assemblages macromoléculaires très variés, chacun ayant des fonctions bien distinctes. Par conséquent, identifier les IPP et les lier à des complexes particuliers est un enjeu crucial mais difficile en biologie. Cette problématique a été au cœur de mon travail de doctorat. Une première partie de mon travail est dédiée à l'amélioration d'une méthode existante

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7

Nordeen, Sarah Ann. "A nanobody suite for yeast scaffold nucleoporins provides details of the Y complex structure and nuclear pore complex assembly." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/127138.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, May, 2020<br>Cataloged from the official PDF of thesis.<br>Includes bibliographical references.<br>Nuclear pore complexes (NPCs) are the main conduits for molecular exchange across the nuclear envelope. The NPC is a modular assembly of ~500 individual proteins, called nucleoporins or nups, that can be classified into three categories: 1. Stably associated scaffolding nups, 2. Peripheral nups, and 3. Phenylalanine-glycine (FG) repeat containing nups that form the permeability barrier of the NPC. Most scaffolding nups

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8

Baum, Natalie [Verfasser]. "Targeting the EGF-receptor and the CD38/NADase in solid and hematological malignancies with nanobody-based heavy chain antibodies and AAV vectors / Natalie Baum." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1241743088/34.

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9

Fleetwood, Filippa. "Bacterial display systems for engineering of affinity proteins." Doctoral thesis, KTH, Proteinteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-156420.

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Directed evolution is a powerful method for engineering of specific affinity proteins such as antibodies and alternative scaffold proteins. For selections from combinatorial protein libraries, robust and high-throughput selection platforms are needed. An attractive technology for this purpose is cell surface display, offering many advantages, such as the quantitative isolation of high-affinity library members using flow-cytometric cell sorting. This thesis describes the development, evaluation and use of bacterial display technologies for the engineering of affinity proteins. Affinity proteins

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10

Duquénois, Isoline. "Modification du tropisme de la glycoprotéine du virus de la stomatite vésiculaire : ciblage de récepteurs d'intérêt." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL098.

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Le transfert d'un cargo, contenu dans une vésicule, vers des cellules d'intérêt reste un défi pour les thérapies ciblées. Les glycoprotéines virales, se liant à un récepteur cellulaire et induisant la fusion membranaire, constituent des outils prometteurs pour ce type d'approche. La glycoprotéine G du VSV est la glycoprotéine virale la plus utilisée pour pseudotyper des lentivirus en thérapie génique. Il y a néanmoins des limites à l'utilisation de G : les récepteurs de G (membres de la famille du LDLR) sont ubiquitaires et présents à la surface de cellules non cibles. Les travaux de l'équipe

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11

Hemmer, Caroline. "Développement et utilisation de nanobodies dirigés contre le Grapevine fanleaf virus (GFLV) en lutte antivirale et comme biocapteur in planta." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ085/document.

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Par leur stabilité, leur petite taille et leur nature monomérique, les domaines variables des immunoglobulines à chaînes lourdes, ou Nanobodies (Nb), sont incontournables en diagnostic et recherche médicale. Pourtant, leur utilisation en agro-biotechnologies demeure confidentielle.Dans l'idée de les utiliser pour étudier et combattre le Grapevine fanleaf virus (GFLV), responsable de la maladie du court-noué très préjudiciable à l'économie viticole mondiale, j'ai produit une collection de Nb spécifiques du GFLV.Fusionné à une protéine fluorescente et exprimé en plante de façon stable, un de ces

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12

HASSAN, AMAL. "FROM PROTEIN STRUCTURE TO DRUG DESIGN (DISCOVERY): TARGETING THE ION CHANNEL ASIC1 AND A PATHOGENIC VARIANT OF HUMAN GELSOLIN." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/629877.

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La conoscenza della struttura tridimensionale di un potenziale target farmacologico apre la via a nuove strategie terapeutiche (ad esempio tramite structure-based drug design (SBDD)) ed è requisito fondamentale per la bioinformatica strutturale. In questo contesto, durante la mia tesi di dottorato, sono state studiate due proteine di interesse biomedico. La prima è una proteina di membrana, l’isoforma 1 dell’Acid Sensing Ion Channel (ASIC), implicata in diverse malattie neurodegenerative. In studi precedenti il diminazene aceturato (DA) si era dimostrato un potente inibitore del canale. Dive

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13

Burbidge, Owen David. "Developing nanobodies to stabilise the tumour suppressor protein p16INK4a." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288375.

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The tumour suppressor protein p16INK4a (p16) is a cyclin-dependent kinase (CDK) inhibitor that plays a key role in the regulation of the cell cycle by controlling the progression of cells through the G1 to S phase transition. Dysregulation of the protein through deletion, silencing or mutation of the gene encoding p16 is implicated in a range of different cancers including melanoma, cervical and oesophageal to name a few. p16 is composed of four ankyrin repeats and it has a very low thermodynamic and kinetic stability and rapidly unfolds even in the absence of denaturants. This low stability m

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14

Broster, Christine. "Caractérisation et Ciblage de Protéines Essentielles via l'utilisation de nanobodies chez Trypanosoma brucei." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0158.

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Les parasites de la classe des Kinetoplastidae, comprenant notamment les trypanosomes et les leishmanies, sont responsables pour plusieurs maladies d’importance socio-économique et de santé publique. La maladie du sommeil, la maladie de Chagas et la leishmaniose, classées comme maladies tropicales négligées (NTD) par l’Organisation mondiale de la santé (OMS) et la Surra, reportée par l’Organisation pour l’alimentation et l’agriculture, des Nations Unies (FAO). La Trypanosomiase Animale Africain sub-saharienne entraîne la mort de 3 millions bovins par an accompagné d'une perte annuelle de l'éco

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15

Fedor, Yoann. "Nouveau biomarqueur en temps réel de cassures double-brin de l'ADN et génotoxicité de la cytolethal distensing toxin." Toulouse 3, 2012. http://thesesups.ups-tlse.fr/2029/.

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L'ADN est constamment la cible de dommages, provenant aussi bien de sources endogènes (propriétés intrinsèques de la macromolécule, métabolisme cellulaire. . . ) qu'exogènes (radiations, contaminants alimentaires. . . ). Parmi ces dommages, les cassures double-brin de l'ADN (CDB) représentent une des lésions les plus cytotoxiques. En réponse à ce danger, la cellule dispose de voies de détection et signalisation impliquant le recrutement de protéines. Au cours de cette réponse des modifications post-traductionnelles de protéines de signalisation et de réparation sont produites au niveau du site

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Gulati, Sahil Gulati. "Modulating G Protein-Coupled Receptor Signaling Pathways with Selective Chemical- and Protein-Based Effector Molecules." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1530642105672697.

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17

Pansieri, Jonathan. "Les amyloïdoses : détection à l'aide de nanoparticules et propriétés optiques originales Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAY105.

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Les amyloïdoses sont des maladies caractérisées par l’agrégation structurée de protéines, sous forme de fibres amyloïdes. Le diagnostic précoce de ces maladies représente un enjeu important, pour la prise en charge de nombreuses pathologies associées. Dans ce travail, nous avons montré le ciblage et la détection de plusieurs fibres amyloïdes, de l’in vitro à l’in vivo. Pour cela, nous avons utilisé des nanoparticules multimodales pour l’imagerie médicale (TEP, IRM), greffées avec diverses molécules ciblant les fibres. Trois types de fibres amyloïdes ont été testées, formées à partir du peptide

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18

Chen, Wei-Hsin Chen. "Localised dosing and nanodetection using a novel scanning ion conductance microscope and its application to Alzheimer's disease." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/279090.

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Scanning ion conductance microscopy (SICM) is a technique for non-contact topographic imaging. In this thesis, a biophysical investigation into Alzheimer's Disease (AD) was carried, with toxic oligomers dosed locally and quantitatively on to single astrocytes using SICM and simultaneously monitoring the response of the target cell. Examination of the effectiveness of antibodies that bind to Abeta or alpha-synuclein (Asyn)peptides depends on the measurement of oligomer-induced abnormal calcium homeostasis in single astrocytes. The method was shown to work at physiological concentrations of olig

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19

Patris, Stéphanie. "Développement d'immunoessais associés aux électrodes sérigraphiées: des particules superparamagnétiques aux nanobodies." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209208.

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Cette thèse a pour vocation de contribuer au développement de différents immunocapteurs ampérométriques associés aux électrodes sérigraphiées (SPE). Les immunocapteurs sont des dispositifs simples associant un anticorps ou un antigène qui assurent la sélectivité à un transducteur (ici une SPE) ;ce dernier transforme la liaison anticorps/antigène en un signal mesurable (ici ampérométrique).<p>Le travail est divisé en deux volets principaux.<p>Le premier est consacré à la mise en œuvre de différents modèles d’immunocapteurs ampérométriques pour le dosage d’anticorps anti-tetani. La vaccination c

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20

Nidhi, Vagisha. "Radiotactic colloids : towards the Decontamination Nanobots." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF052.

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Les méthodes traditionnelles de décontamination restent confrontées à des défis importants, tels que la difficulté d'accès aux espaces complexes ou confinés, la quantité élevée de déchets, etc. Il est encore nécessaire aujourd'hui d'explorer de nouvelles méthodes permettant d'atteindre des géométries complexes avec des processus de décontamination efficaces. Même si les macrorobots se révèlent utiles dans les tâches de décontamination à grande échelle, leur taille limite leur capacité à naviguer dans des environnements complexes et confinés. Les micro ou nano robots, quant à eux, pourraient tr

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21

Payan, Hugo. "Réseaux de protéines associés aux récepteurs de la sérotonine : rôle et options thérapeutiques pour la Maladie d'Alzheimer." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT012.

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La maladie d’Alzheimer, principale forme de démence dans le monde, est devenue un problème de santé publique majeur. Cette pathologie est caractérisée par la présence de deux lésions principales dans le cerveau : la dégénérescence neurofibrillaire composée de protéine Tau hyperphosphorylée et des plaques amyloïdes, agrégats denses de peptides β amyloïdes (Aβ). Le peptide Aβ provient du clivage de la protéine précurseur de l’amyloïde (APP) par des β- et ɣ-sécrétases. Un clivage dit non-amyloïdogène de l’APP existe également, au cours duquel la protéine est clivée par une α-sécrétase (principale

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AMATO, PAOLO. "Swarm-Intelligence Strategy for Diagnosis of Endogenous Diseases by Nanobots." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41950.

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An ambitious long-term goal of medicine is to make analyses and deliver drugs selectively at cell level. In particular such "ideal" drugs should be able to travel through the vasculature, reach the intended target at full concentration, and there act selectively on diseased cells and tissues only, without creating undesired side effects. The state of the art in pursuing this goal is represented by \emph{nanoparticles} \cite{Ferrari2010}, which can be roughly defined as the combination of a drug molecule with a suitable vector of nanoscale dimensions. One of the main limitations of nanopart

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De, pascali Francesco. "Allosteric modulation of follicle stimulating hormone receptor and GPR54 : new tools to study signalling." Thesis, Tours, 2019. http://www.theses.fr/2019TOUR4030.

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Le GPR54 et le RFSH régulent la reproduction en agissant sur l’axe hypothalamus-hypophyse-gonades (HPG). En agissant dans l’hypothalamus, GPR54 est un régulateur proximal de l’axe tandis que le RFSH contrôle la gamétogenèse dans les deux sexes. Ils représentent deux cibles thérapeutiques majeures pour le traitement des problèmes liés à la fertilité. GPR54 et RFSH appartiennent à la superfamille des récepteurs couplés aux protéines G (GPCR). GPR54 active préférentiellement la voie Gαq/PLC/Ca2+ alors que le RFSH induit principalement la voie Gαs/PKA/cAMP. Les deux récepteurs recrutent et activen

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24

Hughes, William L. "Synthesis and characterization of zinc oxide nanostructures for piezoelectric applications." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-08232006-155547/.

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Thesis (Ph. D.)--Materials Science and Engineering, Georgia Institute of Technology, 2007.<br>Wang, Zhong Lin, Committee Chair ; Wong, C.P., Committee Member ; Summers, Christopher J., Committee Member ; Degertekin, F. Levent, Committee Member ; Bottomley, Lawrence A., Committee Member.

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Vachon, Lauren Marie. "Glow: A Novel." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1374695902.

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26

Hoff, Merle. "Kombinatorische Analyse von Nanobody-markierten Epitopen zur Proteinbestimmung." Doctoral thesis, 2021. http://hdl.handle.net/21.11130/00-1735-0000-0005-1565-2.

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27

Romano, Sofia Pereira Constantino. "Novel anti-nucleolin antibodies for targeted cancer therapy." Doctoral thesis, 2018. http://hdl.handle.net/10316/79730.

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Tese de doutoramento em Biologia Experimental e Biomedicina, no ramo de Biotecnologia e Saúde, apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra<br>Cancer is nowadays the second leading cause of death and current therapeutic approaches still reveal ineffective in several cases. Therefore, there is a need to develop more efficacious therapeutic agents, especially for subtypes of cancer where targeted therapies are still missing, and, as such, unmet medical needs are evident. Limited drug penetration into tumors limits the efficacy of therapies target

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Mittelmeier, Lucas. "Multiplexe optische und Rasterkraftmikroskopie für biomedizinische Bildgebung." Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-13FB-B.

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Gomes, Ana Rita Coelho. "Design of a Novel Phage Display Vector to Improve Enrichment of Phages with Antigen-Specific Nanobodies and to Identify the Nanobody Clones of Highest Affinity." Master's thesis, 2019. http://hdl.handle.net/10362/89178.

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Although phage display-based enrichments became a standard procedure, they still suffer from some drawbacks. Nonspecific phage binding limits the enrichment that can be achieved per se-lection round and therefore, in most cases, at least three or four rounds are required to identify the antigen binding nanobodies (Nbs) from the library. Moreover, the release of the phages captured via their antigen-specific Nb on the immobilized antigen is accomplished most often, by a pH shock that will also release the a-specific absorbed phages, thereby generating an unwanted back-ground. However, the bigge

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Houserová, Jana. "Studium interakce receptoru NKp46 s adhesinem Epa1." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-434858.

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One of the key components of the innate immune system are natural killer (NK) cells. The task of these cells is to induce apoptosis in target cells (e.g., cancer or virally infected cells). The target cells are identified by their interaction with surface receptors of the NK cells. On the surface of the NK cells, there are activating and inhibiting receptors. One of the activating receptors is the natural cytotoxicity receptor NKp46. Several ligands of this receptor have been identified, one of them being the epithelial adhesin Epa1 of yeast Candida glabrata. The invasive candidiasis caused by

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Maidorn, Manuel. "Development of Nanobodies to Image Synaptic Proteins in Super-Resolution Microscopy." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-002E-E4D1-D.

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Jeon, Suekyoung. "Analyzing UNC-50/GMH1 dependent membrane trafficking in yeast and C. elegans." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0028-864B-5.

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Sograte, Idrissi Shama. "Optimization of tools for multiplexed super resolution imaging of the synapse." Thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-140A-A.

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Cmunt, Denis. "Příprava fúzních domén lidských imunoreceptorů pro jejich využití v imunoterapii." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-403988.

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The functions of the immune system include immunosurveillance of transformed cells, i.e., the ability to eliminate these cells before they become harmful to the organism. If the transformed cells succeed to escape the immune system surveillance, an oncological disease develops. The tumour immunotherapy aims to stimulate the immune system mechanisms to fight against the tumour. Lately, there's an interest in using NK cells in the immunotherapy of tumours. These cells appertain to the innate immune system and participate in immunosurveillance. When an NK cell encounters a target cell, its activa

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Krüwel, Thomas. "In vivo imaging of the voltage-gated potassium channel Kv10.1 utilizing SPECT in combination with radiolabeled antibodies." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-8635-6.

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Majumder, Puja. "Structural and Functional Investigation of a Multi-drug Efflux Transporter QacA." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/5103.

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The emergence of multi-drug resistance in bacteria is a global health care challenge. One of the effective means of gaining antimicrobial resistance, among superbugs, is through expression of efflux pumps. Quaternary ammonium compound transporters, QacA/B, that are observed in Staphylococcus aureus strains are capable of transporting 30 chemically dissimilar monovalent and divalent cationic antibacterial compounds and dyes. The 14-TM (transmembrane) helix containing transporter QacA, belongs to the drug/H+ antiporter 2 (DHA2) family which is a part of major facilitator superfamily (MFS). MFS t

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alsaiari, shahad. "NANOBOTS Smart Systems to Improve Therapeutics Delivery." Diss., 2018. http://hdl.handle.net/10754/630004.

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With the remarkable advancement in the nanoparticles (NPs)-based drug delivery systems (DDS) over the past several decades, the pharmacological properties associated with conventional free drugs delivery are improved. In this thesis, we report potential candidates for the next-generation NP-based DDS. While natural DDS are promising as they possess exceptional delivery mechanisms and selective targeting, synthetic DDS are more favorable for their low immunogenicity. Our developed natural DDS called magnetotactic bacterial cages (MBC), which is based on magnetotactic bacteria (MTB) as a

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Schrodi, Inken [Verfasser]. "In-vivo-Analyse von Biokompatibilität und Gewebeintegration des synthetischen Knochenersatzstoffes NanoBone / vorgelegt von Inken Schrodi." 2009. http://d-nb.info/1006874437/34.

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