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Dissertations / Theses on the topic 'Nanocarrier systems'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Agarwal, Abhiruchi. "Nanocarrier mediated therapies for the gliomas of the brain." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39468.

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Existing methods of treating glioma are not effective for eradicating the disease. Therefore, new and innovative methods of treatment alone or in combination with existing therapies are necessary. Delivery of therapeutic agents through delivery carriers such as liposomes diminishes the harmful effects of the agent in healthy tissues and allows increased accumulation in the tumor. In addition, targeted chemotherapy using liposomes provides the opportunity for further increase in drug accumulation in tumor. However, the current targeting strategies suffer accelerated plasma clearance and are not

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2

Munson, Jennifer Megan. "Novel nanocarriers for invasive glioma." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41226.

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The invasive nature of glioblastoma (GBM) represents a significant challenge to the standard of care and contributes to poor clinical outcomes. Invasion of tumors into healthy brain restricts chemotherapeutic access and complicates surgical resection. The central hypothesis of the thesis is that an effective anti-invasive agent can enhance the standard chemotherapeutic response in invasive brain tumors. Through a screen of novel compounds, a new anti-invasive small molecule, Imipramine Blue (IB), was identified. This triphenylmethane compound inhibits invasion of highly invasive glioma in vit

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3

Tang, Jingjie. "Innovative imaging systems and novel drug candidates for cancer therapy." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4021.

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Le cancer est l'une des principales causes de décès dans le monde et reste une maladie difficile à traiter du fait des difficultés de pronostic, du développement rapide de métastases et de la résistance aux médicaments. Il en résulte une forte demande en méthodologies d'imagerie innovantes pour le diagnostic précoce et précis ainsi qu’en nouveaux agents anticancéreux possédant de nouveaux mécanismes pour surmonter la résistance aux médicaments. Le but de mon projet de recherche de doctorat était donc de contribuer à cet objectif.La première partie de ma thèse de doctorat a porté sur la créatio

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4

Tang, Jingjie. "Innovative imaging systems and novel drug candidates for cancer therapy." Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4021.

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Le cancer est l'une des principales causes de décès dans le monde et reste une maladie difficile à traiter du fait des difficultés de pronostic, du développement rapide de métastases et de la résistance aux médicaments. Il en résulte une forte demande en méthodologies d'imagerie innovantes pour le diagnostic précoce et précis ainsi qu’en nouveaux agents anticancéreux possédant de nouveaux mécanismes pour surmonter la résistance aux médicaments. Le but de mon projet de recherche de doctorat était donc de contribuer à cet objectif.La première partie de ma thèse de doctorat a porté sur la créatio

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5

Fehse, Susanne [Verfasser]. "Charakterisierung von Cu/Nanocarrier-Komplexen im zellulären System / Susanne Fehse." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1077211937/34.

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6

Mishra, Kaushik. "Folate Receptor-Targeted Polymeric Micellar Nanocarriers as Drug Delivery Systems." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1629218263972419.

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7

Singh, Manu Smriti [Verfasser]. "Nanocarrier system for overcoming multidrug resistance in cancer / Manu Smriti Singh." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1077289200/34.

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8

Kurniasih, Indah Nurita [Verfasser]. "Nanocarrier System for Drug Delivery Based on Hyperbranched Polyglycerol / Indah Nurita Kurniasih." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1043957863/34.

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9

Santos, João Miguel Almeida. "Gene therapy: development of a new nanocarrier system for mitochondrial gene therapy." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1627.

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Mitochondria are unique organelles that have their own genome, the mitochondrial DNA (mtDNA). Although quite small compared to nuclear DNA (nDNA), mutations in mtDNA are quite frequent due to the lack of protection and repair mechanisms. Per consequence, cytopathies and diseases are quite common and mostly associated with high energy demanding tissues such as muscles and the brain. Therefore, the development of a new and efficient mitochondrial gene therapy protocol is seen as a promising approach. During this MSc thesis we try to bring together a new nanocarrier system with the ability

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10

Saeidpour, Siavash [Verfasser]. "Investigation of nanocarriers as drug delivery systems by electron paramagnetic resonance spectroscopy / Siavash Saeidpour." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1214241174/34.

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11

Corace, Giuseppe <1983&gt. "Multifunctional nanocarriers encapsulating anti-Alzheimer drug for nasal delivery to central nervous system." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4545/1/Corace_Giuseppe_Tesi.pdf.

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Alzheimer's disease (AD) is a fatal neurodegenerative condition characterized clinically by progressive memory loss and irreversible cognitive deterioration. It has been shown that there is a progressive degeneration of the brain cholinergic neurons which leads to the appearance of cognitive symptoms of the disease. The aim of this work was the formulation of multifunctional nanocarriers for nasal administration of tacrine-HCl (THA). This route has many advantages; in particular is possible to convey the drug directly to the Central Nervous System, through the olfactory bulb. In particular, we

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Corace, Giuseppe <1983&gt. "Multifunctional nanocarriers encapsulating anti-Alzheimer drug for nasal delivery to central nervous system." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4545/.

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Alzheimer's disease (AD) is a fatal neurodegenerative condition characterized clinically by progressive memory loss and irreversible cognitive deterioration. It has been shown that there is a progressive degeneration of the brain cholinergic neurons which leads to the appearance of cognitive symptoms of the disease. The aim of this work was the formulation of multifunctional nanocarriers for nasal administration of tacrine-HCl (THA). This route has many advantages; in particular is possible to convey the drug directly to the Central Nervous System, through the olfactory bulb. In particular, we

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13

Wa, Kasongo Kasongo. "An investigation into the feasibility of incorporating didanosine into innovative solid lipid nanocarriers." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003278.

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The research undertaken in these studies aimed to investigate the feasibility of developing and manufacturing innovative solid lipid carriers, such as solid lipid nanoparticles (SLN) and/or nanostructured lipid carriers (NLC) using a hot high pressure homogenization method, for didanosine(DDI). In addition, studies using in vitro differential protein adsorption were undertaken to establish whether the SLN and/or NLC have the potential to deliver DDI to the central nervous system (CNS). Prior to initiating pre-formulation, formulation development and optimization studies of DDI-Ioaded SLN and/o

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14

Bühler, Jasmin [Verfasser]. "Synthese und Charakterisierung zylindrischer Poly(2-oxazolin)bürsten als Nanocarrier für Drug Delivery Systeme / Jasmin Bühler." Mainz : Universitätsbibliothek Mainz, 2013. http://d-nb.info/1036706710/34.

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15

Stefani, Stefano [Verfasser]. "Core-shell and core-amphiphilic branched shell nanocarriers based on biodegradable hyperbranched polymers, as potential drug delivery systems / Stefano Stefani." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1104733854/34.

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16

Saletti, Mario. "A multidisciplinary approach to the development of innovative tools for pharmaceutical and technological applications." Doctoral thesis, Università di Siena, 2023. https://hdl.handle.net/11365/1227081.

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The research activity carried out during the Ph.D. in Chemical and Pharmaceutical Sciences has regarded the design, synthesis, and characterization of innovative tools relevant to both pharmaceutical and technological fields. Great interest has been dedicated to the investigation of the “affinity polymerization” mechanism of novel polymeric materials founded on repetitive monomeric units based on the 3-phenylbenzofulvene scaffold that spontaneously polymerize by simple removal of the solvent. In this context, the attention has been focused on the synthesis of novel benzofulvene-based derivativ

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17

Costa, Gouveia Joana. "Utilisation de nanoparticules pour le développement de nouvelles thérapies antituberculeuses." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S035/document.

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La tuberculose (TB) est un problème de santé mondiale majeur à l’origine de 10.4 millions de nouveaux cas et 1.8 millions de morts en 2015 selon l’Organisation Mondiale de la Santé (OMS). Cette maladie est causée par la bactérie Mycobacterium tuberculosis (Mtb) qui infecte principalement les poumons et se transmet par l'inhalation d’aérosols contaminés.Le traitement de TB nécessite la prise quotidienne d’antibiotiques pendant 6 mois, dont une mauvaise utilisation peut être à l’origine de l’apparition de souches Mtb multi-résistantes.La nouvelle stratégie de l’OMS, “End TB”, vise à réduire de 9

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18

Liu, Juan. "Nouveaux systèmes nanométriques et ph dépendant pour le transport de médicaments contre les phénomènes de résistances." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4072.

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La résistance aux médicaments constitue un obstacle majeur pour le traitement du cancer. Les systèmes nanoparticulaires de délivrance de médicaments (nanoparticule drug delivery system, NDDS) sont pressentis pour apporter un nouvel espoir dans le traitement du cancer afin de surmonter la résistance aux médicaments en délivrant spécifiquement l’agent anticancéreux dans la lésion tumorale par effet EPR. Cela aura pour effet d’augmenter la concentration locale en médicaments et par conséquent d’améliorer l'efficacité thérapeutique tout en épargnant les tissus sains afin d'éviter les effets second

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Liu, Juan. "Nouveaux systèmes nanométriques et ph dépendant pour le transport de médicaments contre les phénomènes de résistances." Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4072.

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La résistance aux médicaments constitue un obstacle majeur pour le traitement du cancer. Les systèmes nanoparticulaires de délivrance de médicaments (nanoparticule drug delivery system, NDDS) sont pressentis pour apporter un nouvel espoir dans le traitement du cancer afin de surmonter la résistance aux médicaments en délivrant spécifiquement l’agent anticancéreux dans la lésion tumorale par effet EPR. Cela aura pour effet d’augmenter la concentration locale en médicaments et par conséquent d’améliorer l'efficacité thérapeutique tout en épargnant les tissus sains afin d'éviter les effets second

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20

Oliveira, Sara Alexandra Craveiro. "Novos sistemas terapêuticos para o tratamento de doenças negligenciadas provocadas por protozoários: especial ênfase para Leishmaniose e doença de Chagas." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5185.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>As Doenças Negligenciadas ou doenças tropicais, advêm de um conjunto de factores biológicos, ecológicos e evolutivos, com uma elevada incidência nos países de clima tropical. A situação económica desfavorável e o baixo desenvolvimento, estão também directamente relacionados com a sua ocorrência. Estas doenças representam um encargo significativo para a saúde em certas partes do mundo. Os medicamentos disponíveis no tratamento das

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21

"Study of chitosan-based nanocarrier for drug delivery." 2011. http://library.cuhk.edu.hk/record=b5894837.

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Ng, Yiu Ming.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 99-114).<br>Abstracts in English and Chinese.<br>Acknowledgements --- p.2<br>Abstract --- p.3<br>摘要 --- p.5<br>Content --- p.6<br>List of abbreviations and symbols --- p.10<br>Chapter Chapter 1 - --- Introduction --- p.13<br>Chapter 1.1 --- Introduction to nanoparticles (NPs) --- p.13<br>Chapter 1.2 --- How to treat solid cancers using nanoparticle drugs --- p.17<br>Chapter 1.3 --- What is Chitosan (CS)? --- p.22<br>Chapter 1.4 --- Possible peptide candidates to be

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22

Steege, Karen Elizabeth. "Fluorescence probing of complex solvent environments polymeric nanocarrier aggregates and rilpivirine." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17396.

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23

Ribeiro, Ricardo. "Development and Characterization of Nanocarrier Systems for the Delivery of Antitubercular Drugs." Dissertação, 2013. http://hdl.handle.net/10216/75044.

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24

Ribeiro, Ricardo Leandro Delindro. "Development and Characterization of Nanocarrier Systems for the Delivery of Antitubercular Drugs." Master's thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/69357.

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25

Ribeiro, Ricardo Leandro Delindro. "Development and Characterization of Nanocarrier Systems for the Delivery of Antitubercular Drugs." Dissertação, 2013. https://repositorio-aberto.up.pt/handle/10216/69357.

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26

Henriques, Simaura Grilo. "Development of a novel polymeric nanocarrier to mediate gene therapy for Hepatocellular Carcinoma." Master's thesis, 2021. http://hdl.handle.net/10316/97940.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>Over the past decades, cancer became one of the major health problems worldwide. Among the most common types of cancers is liver cancer, which includes hepatocellular carcinoma. Hepatocellular carcinoma is the fourth leading cause of cancer-related death, and its incidence has been growing. The currently available treatment options are poorly effective and severely restricted when the disease is advanced. In these cases, systemic chemotherapy is usually applied. However, it is always accompanied by undesi

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27

Eires, Inês Fernandes. "Relatórios de Estágio e Monografia intitulada “Oral delivery of siRNA-containing lipid-based nanocarriers: challenges and recent advances”." Master's thesis, 2021. http://hdl.handle.net/10316/98985.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O presente documento é o fruto do trabalho teórico e prático desenvolvido no âmbito da unidade curricular “Estágio”, integrada, no 2º semestre do 5º ano, no plano de estudos do Mestrado Integrado em Ciências Farmacêuticas (MICF) da Faculdade de Farmácia da Universidade de Coimbra (FFUC). A apresentação, discussão pública e aprovação deste trabalho são condições necessárias para a conclusão do curso e consequente obtenção do grau de Mestre em Ciências Farmacêuticas. O documento encontra-s

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Saad, Maha. "Receptor-targeted nanocarriers for tumor specific treatment and imaging." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17560.

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Vakil, Ronak. "Polymeric micelle nanocarriers for the treatment of disseminated candidiasis /." 2006. http://www.library.wisc.edu/databases/connect/dissertations.html.

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30

Horvat-Csóti, [geb Horvat] Sonja. "Development of Nanocarriers for Treatment and Diagnostics of Aspergillosis." Doctoral thesis, 2021. https://doi.org/10.25972/OPUS-23821.

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This thesis aimed to evaluate the possibility to use nanoparticles as antifungal drug carriers as well as their potential application in screening and diagnostics of invasive aspergillosis. The interaction of nanogels, superparamagnetic iron oxide nanoparticles (SPIOs) and gold nanoparticles (GNP) with fungal-specific polysaccharides, cells and biofilms was investigated. Firstly, it was evaluated how the charge of nanogels influence their interaction with fungal cells. Linear poly(glycidol)s (pG) and poly(2-methyl-2-oxazoline) (pMOx) polymers were synthesized and further functionalized with th

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Huang, Chen-yen, and 黃鉦晏. "Preparation and evaluation of nanocarrier formulation of rosiglitazone for IV delivery system." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/60231608375112189296.

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碩士<br>高雄醫學大學<br>藥學系碩士班<br>105<br>Rosiglitazone (RSG) is a potent peroxisome-proliferator activated receptor-γ (PPARγ) agonist and an effective antidiabetic drug which has effect on insulin-sensitizing. The PPARγ is a nuclear receptor activated by fatty acids and fat metabolites. RSG is able to increase glucose influx into adipose tissue and muscle. Recent studies showed that the activation of PPARγ has neuroprotection effect against brain ischemic injury as stroke. The purpose of the study is to develop suitable lipid nanocarrier, including liposomes and solid lipid nanoparticles of RSG. L

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32

Rosa, Daniela Maria Barata. "Gold nanoparticulate systems for new anticancer compounds delivery." Master's thesis, 2014. http://hdl.handle.net/10362/13879.

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My master studies have resulted in the following publication: Martins P, Rosa D, Fernandes AR, Baptista PV. 2014. Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine. Recent Patents in Nanomedicine. 3(2):105-118.

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Almeida, Mafalda Guimarães Coimbra. "Nanocarriers for skin delivery of cosmetic antioxidants." Master's thesis, 2018. http://hdl.handle.net/10437/8886.

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Orientação: Joana Portugal Mota<br>Os etossomas são compostos por fosfolípidos, etanol e água. O etanol e um eficiente potenciador da permeação, perturbação da bicamada lipídica da pele, que afeta a região intercelular do estrato córneo. A sua aplicação em produtos cosméticos tem em vista aumentar a estabilidade dos produtos químicos cosmeticos, diminuir a irritação da pele de outros compostos cosméticos e melhorar a permeação da pele. Neste estudo, comparamos diferentes antioxidantes bem conhecidos na indústria de cosméticos, como o Ácido Ferúlico e a Rutina. As concentrações estudadas for

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34

Callari, Manuela. "Polymer nanocarriers to enhance the efficiency of platinum-based chemotherapeutics." Thesis, 2016. http://hdl.handle.net/1959.7/uws:41253.

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The aim of this Thesis was to design and prepare polymer nanocarriers capable of encapsulating, carrying and delivering platinum-based chemotherapeutics. Polymer nanocarrier have been widely studied and employed as platinum drug delivery systems with the primary scope to overcome limitations presented by platinum-based chemotherapeutics. The conjugation of platinum onto polymers, however, presents some challenges, and, although there has been great progress in the field of drug delivery in the past years, to date only three polymer nanocarriers for platinum drugs have found their way to the cl

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Flavia, Carton. "Biocompatible nanocarriers for delivering drugs to skeletal muscle cells: a therapeutic option for myotonic dystrophy?" Doctoral thesis, 2019. http://hdl.handle.net/11562/994651.

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Myotonic dystrophy (DM) represents a genetic disorder characterized by progressive dysfunction of multiple organs and tissues (e.g. skeletal, cardiac, and smooth muscle; the central nervous systems) among which the most severely affected is the skeletal muscle; this condition leads patients to a progressive muscle weakness, wasting and myotonia. The molecular pathogenetic mechanism of DM type 1 (or Steinert’s) disease is the expansion of a (CTG)n triplet in 3’ UTR region of the Dystrophia Myotonica Protein Kinase (DMPK) gene, while the (CCTG)n quadruplet expansion in the first intron of the c

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RIGHESCHI, CHIARA. "Development and optimization of nanocarriers for delivery of natural and semi-synthetic compounds in cancer therapy." Doctoral thesis, 2013. http://hdl.handle.net/2158/804100.

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The aim of the work has been the development and characterization of three different nanocarriers: solid lipid nanoparticles, polymeric nanocapsules and liposomes for the delivery of natural and semi-synthetic anticancer compounds.

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Frias, Iúri André Teixeira. "Design, development and characterization of innovative lipid nanocarrier-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/85936.

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Frias, Iúri André Teixeira. "Design, development and characterization of innovative lipid nanocarrier-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/85936.

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Melo, André Ferreira de. "Nanoestratégias para Cedência de Fármacos no Sistema Nervoso Central." Master's thesis, 2018. http://hdl.handle.net/10316/84636.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Um dos principais fatores limitantes da ação de fármacos no Sistema Nervoso Central é a existência da Barreira Hematoencefálica. A existência desta estrutura impossibilita o alcance do Sistema Nervoso Central por parte de fármacos de interesse resultand

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Yang, Shih Yun, and 楊詩韻. "The development and evaluation of the skin delivery systems of the drugs for dermal use: Dual-drug nanocarriers and selenium compounds." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/73454382682762104546.

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碩士<br>長庚大學<br>中醫學系天然藥物<br>99<br>Skin is directly exposed to a number of oxidative stress include ultraviolet (UV) and micro-organisms which induced acne, skin cancer, photoaging and other skin diseases. Acne is a common dermatological disorder caused by multiple pathological factors of the skin. Traditionally, topically delivered tretinoin has been the main treatment strategy which has a comedolytic effect; moreover, in order to achieve better therapeutic efficacy, the aim of this study was to deliver tretinoin combined with tetracycline by lipid nanoparticles to produce antibacterial, anti-ho

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Carvalho, João Pedro Fernandes. "Multi-layered nanosystems for the controlled release of anticancer drugs." Master's thesis, 2018. http://hdl.handle.net/10773/25644.

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Cancer is one of the leading causes of death worldwide, and current therapeutic options present numerous drawbacks. Chemotherapy, specifically, is associated with widely known side effects. However, and due to the scientific and technologic advances of the past years, a new approach to this dilemma appears in nanomedicine: the use of nanosystems capable of releasing the anticancer drugs in a controlled way and only at the designated cells. These nanosystems may be obtained from numerous materials, including biopolymers, and by various techniques. Specifically, the work described here consists

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Satyanarayana, T. B. N. "Design And Synthesis Of Bile Acid Derived Oligomers And Study Of Their Aggregation And Potential Applications." Thesis, 2011. https://etd.iisc.ac.in/handle/2005/2429.

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Chapter 1: Amphiphilic self-assembled systems as nanocarriers Nanocarriers are the nanometric size molecular assemblies that are used for the transport of small molecules into their non-solvating environments. These systems find major applications as drug delivery systems (DDS) in pharmacological research. These drug delivery systems improves solubility and stability of the drug molecules through encapsulation and also offer additional advantages like target specificity and stimuli responsive release of the drug molecules. Several types of DDS are reported in the literature, which can be pre

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Satyanarayana, T. B. N. "Design And Synthesis Of Bile Acid Derived Oligomers And Study Of Their Aggregation And Potential Applications." Thesis, 2011. http://etd.iisc.ernet.in/handle/2005/2429.

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Chapter 1: Amphiphilic self-assembled systems as nanocarriers Nanocarriers are the nanometric size molecular assemblies that are used for the transport of small molecules into their non-solvating environments. These systems find major applications as drug delivery systems (DDS) in pharmacological research. These drug delivery systems improves solubility and stability of the drug molecules through encapsulation and also offer additional advantages like target specificity and stimuli responsive release of the drug molecules. Several types of DDS are reported in the literature, which can be prep

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44

Piazzini, Vieri. "Nano-drug delivery systems: a useful approach to improve the biopharmaceutical properties and the pharmacological potential of plant-derived molecules - Nanosistemi per il drug delivery: un valido approccio per migliorare le proprietà biofarmaceutiche e farmacologiche di sostanze di origine vegetale." Doctoral thesis, 2019. http://hdl.handle.net/2158/1150124.

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Recently, the use of herbal drugs has been increased all over the world due to their therapeutic effects and fewer adverse effects as compared to conventional medicines. However, many herbal drugs and herbal extracts demonstrate low in vivo activity due to their poor solubility, improper molecular size or high metabolism, scarce absorption and bioavailability. Novel drug delivery systems open the door towards the development of enhancing bioavailability of plant-derived molecules. The innovative formulations are reported to have remarkable advantages over conventional formulations of plant ac

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