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Journal articles on the topic 'Nanocarrier systems'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kang, Yunxiang, Sunxin Zhang, Guoqi Wang, et al. "Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy." Pharmaceutics 16, no. 11 (2024): 1384. http://dx.doi.org/10.3390/pharmaceutics16111384.

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Dermatoses are among the most prevalent non-fatal conditions worldwide. Given this context, it is imperative to introduce safe and effective dermatological treatments to address the diverse needs and concerns of individuals. Transdermal delivery technology offers a promising alternative compared to traditional administration methods such as oral or injection routes. Therefore, this review focuses on the recent achievements of nanocarrier-based transdermal delivery technology for dermatological therapy, which summarizes diverse delivery strategies to enhance skin penetration using various nanoc

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Mukherjee, Soumajit, Zuzana Bytesnikova, Amir M. Ashrafi, Vojtech Adam, and Lukas Richtera. "Graphene Oxide as a Nanocarrier for Biochemical Molecules: Current Understanding and Trends." Processes 8, no. 12 (2020): 1636. http://dx.doi.org/10.3390/pr8121636.

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The development of an advanced and efficient drug delivery system with significant improvement in its efficacy and enhanced therapeutic value is one of the critical challenges in modern medicinal biology. The integration of nanomaterial science with molecular and cellular biology has helped in the advancement and development of novel drug delivery nanocarrier systems with precision and decreased side effects. The design and synthesis of nanocarriers using graphene oxide (GO) have been rapidly growing over the past few years. Due to its remarkable physicochemical properties, GO has been extensi

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Mehanna, Mohammed M., and Kawthar K. Abla. "siRNA nanohybrid systems: false hope or feasible answer in cancer management." Therapeutic Delivery 13, no. 2 (2022): 109–33. http://dx.doi.org/10.4155/tde-2021-0068.

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Finding out predisposition and makeup alterations in cancer cells has prompted the exploration of exogenous small interference RNA (siRNA) as a therapeutic agent to deal with cancer. siRNA is subjected to many limitations that hinder its cellular uptake. Various nanocarriers have been loaded with siRNA to improve their cellular transportation and have moved to clinical trials. However, many restrictions as low encapsulation efficiency, nanocarrier cytotoxicity and premature release of siRNA have impeded the single nanocarrier use. The realm of nanohybrid systems has emerged to overcome these l

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Suman, Sah Kanu, Patel Abhimanyu, Ojha Abhijeet, Jaswal Saloni, and Chaudhary Praveen. "Lipid-Based Nanocarrier as Bioactive Transporter for Peptide Delivery: A Recent Update." International Journal of Pharmacy and Biological Sciences-IJPBS 13, no. 2 (2023): 108–20. https://doi.org/10.5281/zenodo.8310384.

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Lipid-based Nanocarriers are becoming popular nowadays because of their potential application in oral drug delivery systems having advantages like strong compatibility, and low toxicity. The bioactive molecules for nanocarrier drug delivery systems play a role in the promising treatment of diseases like urinary tract infection, dental problems, cancer, etc. To overcome the problem i.e., physical, and chemical unstability, various types of nanocarrier delivery systems that stabilize by using approaches of encapsulation technology are introduced. Lipid nanoparticles are stabilized by adding emul

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Jain, Dhara, Md Abdur Rashid, and Farhan J. Ahmad. "Recent Advances in Targeted Drug Delivery Approaches Using Lipidic and Polymeric Nanocarriers for the Management of Alzheimer’s Disease." Current Pharmaceutical Design 27, no. 43 (2021): 4388–403. http://dx.doi.org/10.2174/1381612827666210927163258.

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: Drug delivery to the brain has been a significant challenge in treating neurodegenerative disorders such as Alzheimer's disease due to the presence of the blood-brain barrier, which primarily obstructs the access of drugs and biomolecules into the brain. Several methods to overcome the blood-brain barrier have been employed, such as chemical disruption, surgical intervention, focused ultrasound, intranasal delivery, and the use of nanocarriers. Nanocarrier systems remain the method of choice and have shown promising results over the past decade to achieve better drug targeting. Polymeric nan

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Werengowska-Ciećwierz, Karolina, Marek Wiśniewski, Artur P. Terzyk, and Sylwester Furmaniak. "The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System." Advances in Condensed Matter Physics 2015 (2015): 1–27. http://dx.doi.org/10.1155/2015/198175.

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Nanomedicine is, generally, the application of nanotechnology to medicine. The term nanomedicine includes monitoring, construction of novel drug delivery systems, and any possible future applications of nanotechnology and nanovaccinology. In this review, the most important ligand-nanocarrier and drug-nanocarrier bioconjugations are described. The detailed characterizations of covalently formed bonds between targeted ligand and nanocarrier, including amide, thioether, disulfide, acetyl-hydrazone and polycyclic groups, are described. Also, the coupling of small elements and heteroatoms in the fo

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Kamal, Singh Rathore Jain Monal*. "Nanocarriers Revolutionizing Transdermal Drug Delivery: A Comprehensive Review of Recent Advances." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1753–65. https://doi.org/10.5281/zenodo.12806579.

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Nanocarrier-based transdermal drug delivery systems (TDDS) represent cutting-edge innovations in delivery methods, offering enhanced drug penetration through the skin, which serves as a significant barrier in traditional TDDS. This review aims to offer a comprehensive analysis of nanocarrier-based transdermal drug delivery systems (TDDS), focusing on their mechanisms, types, advantages, challenges, and future prospects. The primary objective is to highlight the key benefits of these systems, including improved drug permeability, controlled and sustained release, targeted delivery, reduced syst

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Nelemans, Levi Collin, and Leonid Gurevich. "Drug Delivery with Polymeric Nanocarriers—Cellular Uptake Mechanisms." Materials 13, no. 2 (2020): 366. http://dx.doi.org/10.3390/ma13020366.

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Nanocarrier-based systems hold a promise to become “Dr. Ehrlich’s Magic Bullet” capable of delivering drugs, proteins and genetic materials intact to a specific location in an organism down to subcellular level. The key question, however, how a nanocarrier is internalized by cells and how its intracellular trafficking and the fate in the cell can be controlled remains yet to be answered. In this review we survey drug delivery systems based on various polymeric nanocarriers, their uptake mechanisms, as well as the experimental techniques and common pathway inhibitors applied for internalization

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Gupta, Purnima, Evelyn Garcia, Amrita Sarkar, et al. "Nanoparticle Based Treatment for Cardiovascular Diseases." Cardiovascular & Hematological Disorders-Drug Targets 19, no. 1 (2019): 33–44. http://dx.doi.org/10.2174/1871529x18666180508113253.

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Nanotechnology has gained increased attention for delivering therapeutic agents effectively to the cardiovascular system. Heart targeted nanocarrier based drug delivery is a new, effective and efficacious approach for treating various cardiac related disorders such as atherosclerosis, hypertension, and myocardial infarction. Nanocarrier based drug delivery system circumvents the problems associated with conventional drug delivery systems, including their nonspecificity, severe side effects and damage to the normal cells. Modification of physicochemical properties of nanocarriers such as size,

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Su, Shi, and Peter M. Kang. "Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems." Pharmaceutics 12, no. 9 (2020): 837. http://dx.doi.org/10.3390/pharmaceutics12090837.

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Nanotechnologies have attracted increasing attention in their application in medicine, especially in the development of new drug delivery systems. With the help of nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization have also significantly improved the targeting capacity and therapeutic efficacy of the nanocarrier assisted drug delivery system. In this review, we evaluate recent advances in the

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Malliappan, Sivakumar P., Palanivel Kandasamy, Siva Chidambaram, Devanand Venkatasubbu, Sathish K. Perumal, and Abimanyu Sugumaran. "Breast Cancer Targeted Treatment Strategies: Promising Nanocarrier Approaches." Anti-Cancer Agents in Medicinal Chemistry 20, no. 11 (2020): 1300–1310. http://dx.doi.org/10.2174/1871520619666191022175003.

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Breast cancer is the second most common cancer that causes death among women worldwide. Incidence of breast cancer is increasing worldwide, and the age at which breast cancer develops has shifted from 50- 70 years to 30-40 years. Chemotherapy is the most commonly used effective treatment strategy to combat breast cancer. However, one of the major drawbacks is low selective site-specificity and the consequent toxic insult to normal healthy cells. The nanocarrier system is consistently utilised to minimise the various limitations involved in the conventional treatment of breast cancer. The nanoc

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Visuddho, Visuddho, Princella Halim, Helen Helen, et al. "Modulation of Apoptotic, Cell Cycle, DNA Repair, and Senescence Pathways by Marine Algae Peptides in Cancer Therapy." Marine Drugs 22, no. 8 (2024): 338. http://dx.doi.org/10.3390/md22080338.

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Marine algae, encompassing both macroalgae and microalgae, have emerged as a promising and prolific source of bioactive compounds with potent anticancer properties. Despite their significant therapeutic potential, the clinical application of these peptides is hindered by challenges such as poor bioavailability and susceptibility to enzymatic degradation. To overcome these limitations, innovative delivery systems, particularly nanocarriers, have been explored. Nanocarriers, including liposomes, nanoparticles, and micelles, have demonstrated remarkable efficacy in enhancing the stability, solubi

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Rakotondrabe, Tojofaniry Fabien, Min-Xia Fan, Felix Wambua Muema, and Ming-Quan Guo. "Modulating Inflammation-Mediated Diseases via Natural Phenolic Compounds Loaded in Nanocarrier Systems." Pharmaceutics 15, no. 2 (2023): 699. http://dx.doi.org/10.3390/pharmaceutics15020699.

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The global increase and prevalence of inflammatory-mediated diseases have been a great menace to human welfare. Several works have demonstrated the anti-inflammatory potentials of natural polyphenolic compounds, including flavonoid derivatives (EGCG, rutin, apigenin, naringenin) and phenolic acids (GA, CA, etc.), among others (resveratrol, curcumin, etc.). In order to improve the stability and bioavailability of these natural polyphenolic compounds, their recent loading applications in both organic (liposomes, micelles, dendrimers, etc.) and inorganic (mesoporous silica, heavy metals, etc.) na

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Misra, Shivendra, Vivekanand Prajapati, and Dr N. T. Pramathesh Mishra. "Potentials of Polymeric Nanocarriers Loaded with Clarithromycin for Antibacterial Activity." International Journal of Advanced Pharmaceutical Sciences and Research 3, no. 1 (2022): 1–4. http://dx.doi.org/10.54105/ijapsr.b4014.123122.

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Clarithromycin (CTM) is a semisynthetic derivative of erythromycin that have been reported to exhibit potential antibiotic activities mostly against the gram-negative and gram-positive bacteria, lower/upper respiratory tract and skin infection causing pathogens. It is widely used for the prevention and management of infections due to Mycobacterium avium complexes and peptic ulcers due to Helicobacter pylori. Various marketed formulation of CTM in the form of tablets, capsules and other conventional dosage forms is available as anti-infective, however the drug itself has several limitations. Th

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Shivendra, Misra, Prajapati Vivekanand, and N. T. Pramathesh Mishra Dr. "Potentials of Polymeric Nanocarriers Loaded with Clarithromycin for Antibacterial Activity." International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) 3, no. 1 (2022): 1–4. https://doi.org/10.54105/ijapsr.B4014.123122.

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<strong>Abstract:</strong> Clarithromycin (CTM) is a semisynthetic derivative of erythromycin that have been reported to exhibit potential antibiotic activities mostly against the gram-negative and gram-positive bacteria, lower/upper respiratory tract and skin infection causing pathogens. It is widely used for the prevention and management of infections due to Mycobacterium avium complexes and peptic ulcers due to Helicobacter pylori. Various marketed formulation of CTM in the form of tablets, capsules and other conventional dosage forms is available as anti-infective, however the drug itself

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16

Kim, Jinku. "Smart Nanocarriers in Cosmeceuticals Through Advanced Delivery Systems." Biomimetics 10, no. 4 (2025): 217. https://doi.org/10.3390/biomimetics10040217.

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Nanomaterials have revolutionized various biological applications, including cosmeceuticals, enabling the development of smart nanocarriers for enhanced skin delivery. This review focuses on the role of nanotechnologies in skincare and treatments, providing a concise overview of smart nanocarriers, including thermo-, pH-, and multi-stimuli-sensitive systems, focusing on their design, fabrication, and applications in cosmeceuticals. These nanocarriers offer controlled release of active ingredients, addressing challenges like poor skin penetration and ingredient instability. This work discusses

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Siddiqui, Ruqaiyyah, Anania Boghossian, Muhammad Kawish, et al. "Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties." Diseases 11, no. 2 (2023): 58. http://dx.doi.org/10.3390/diseases11020058.

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Given the opportunity and access, pathogenic protists (Balamuthia mandrillaris and Naegleria fowleri) can produce fatal infections involving the central nervous system. In the absence of effective treatments, there is a need to either develop new antimicrobials or enhance the efficacy of existing compounds. Nanocarriers as drug delivery systems are gaining increasing attention in the treatment of parasitic infections. In this study, novel nanocarriers conjugated with amphotericin B and curcumin were evaluated for anti-amoebic efficacy against B. mandrillaris and N. fowleri. The results showed

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Wang, Tianshuai, Chen Wu, Yanggen Hu, Yan Zhang, and Junkai Ma. "Stimuli-responsive nanocarrier delivery systems for Pt-based antitumor complexes: a review." RSC Advances 13, no. 24 (2023): 16488–511. http://dx.doi.org/10.1039/d3ra00866e.

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Endogenous stimuli responsive nanocarrier, extracorporeal stimuli responsive nanocarrier and multistimuli responsive nanocarrier drug delivery systems of platinum-based antitumor drugs were summarized.

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Nasr, Nasr Eldin Hussein, Aliaa Nabil ElMeshad, and Ahmed Roshdy Fares. "Nanocarrier Systems in Taste Masking." Scientia Pharmaceutica 90, no. 1 (2022): 20. http://dx.doi.org/10.3390/scipharm90010020.

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Taste is the most crucial organoleptic parameter affecting patient compliance in the case of drugs with poor palatability. Taste masking is a major challenge for the development of orally ingested active pharmaceutical constituents in the pharmaceutical industry. Numerous conventional taste-masking techniques have been extensively studied. In parallel, affecting the drug solubility or release is a major concern of conventional taste-masking techniques. Recently, many nanocarrier systems have been introduced, claiming the advantage of effective taste masking without affecting either the drug so

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Vega-Villa, Karina R., Jody K. Takemoto, Jaime A. Yáñez, Connie M. Remsberg, M. Laird Forrest, and Neal M. Davies. "Clinical toxicities of nanocarrier systems." Advanced Drug Delivery Reviews 60, no. 8 (2008): 929–38. http://dx.doi.org/10.1016/j.addr.2007.11.007.

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CHRISTIE, J., and U. KOMPELLA. "Ophthalmic light sensitive nanocarrier systems." Drug Discovery Today 13, no. 3-4 (2008): 124–34. http://dx.doi.org/10.1016/j.drudis.2007.12.005.

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Ashok Simhadri, Mounika Devi Dommeti, and Jupiter Sana. "A Comprehensive Review on the Nanotechnology-based Intranasal Drug Delivery Systems for Brain Targeting." Journal of Pharma Insights and Research 2, no. 4 (2024): 015–23. http://dx.doi.org/10.69613/fjsep132.

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Intranasal drug delivery has emerged as a promising non-invasive route for targeting the central nervous system, bypassing the blood-brain barrier and minimizing systemic side effects. Recent advancements in nanotechnology-based intranasal delivery systems have shown potential to enhance drug bioavailability, improve brain targeting, and overcome limitations associated with conventional delivery methods. Various nanocarrier systems, including liposomes, solid lipid nanoparticles, polymeric nanoparticles, and dendrimers, possess unique properties applicable to nose-to-brain drug delivery. The a

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Sarma, Kangkan, Md Habban Akther, Irfan Ahmad, et al. "Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer." Molecules 29, no. 5 (2024): 1076. http://dx.doi.org/10.3390/molecules29051076.

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Lung cancer has the lowest survival rate due to its late-stage diagnosis, poor prognosis, and intra-tumoral heterogeneity. These factors decrease the effectiveness of treatment. They release chemokines and cytokines from the tumor microenvironment (TME). To improve the effectiveness of treatment, researchers emphasize personalized adjuvant therapies along with conventional ones. Targeted chemotherapeutic drug delivery systems and specific pathway-blocking agents using nanocarriers are a few of them. This study explored the nanocarrier roles and strategies to improve the treatment profile’s eff

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Male, David, and Radka Gromnicova. "Nanocarriers for Delivery of Oligonucleotides to the CNS." International Journal of Molecular Sciences 23, no. 2 (2022): 760. http://dx.doi.org/10.3390/ijms23020760.

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Nanoparticles with oligonucleotides bound to the outside or incorporated into the matrix can be used for gene editing or to modulate gene expression in the CNS. These nanocarriers are usually optimised for transfection of neurons or glia. They can also facilitate transcytosis across the brain endothelium to circumvent the blood-brain barrier. This review examines the different formulations of nanocarriers and their oligonucleotide cargoes, in relation to their ability to enter the brain and modulate gene expression or disease. The size of the nanocarrier is critical in determining the rate of

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Piyush, Taskar Shreya Relkar* Rajashree Shinde. "Targeted Nanocarrier Systems in Cancer Therapy: Innovations, Challenges, And Future Directions." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 5040–48. https://doi.org/10.5281/zenodo.15557892.

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Multidrug resistance, systemic toxicity, and non-specific drug distribution are ongoing issues in cancer treatment that reduce the effectiveness of traditional medications. By precisely delivering therapeutic drugs to tumor locations, targeted nanocarrier systems have become a promising approach that can increase treatment efficacy while reducing side effects. Recent developments in targeted nanocarriers, such as liposomes, polymeric nanoparticles, dendrimers, micelles, and inorganic platforms, are thoroughly examined in this book. We go over tumor-specific targeting techniques like active tar

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Kulikov, Pavel P., Anna L. Luss, Levi C. Nelemans, et al. "Synthesis, Self-Assembly and In Vitro Cellular Uptake Kinetics of Nanosized Drug Carriers Based on Aggregates of Amphiphilic Oligomers of N-Vinyl-2-pyrrolidone." Materials 14, no. 20 (2021): 5977. http://dx.doi.org/10.3390/ma14205977.

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Development of nanocarrier-based drug delivery systems is a major breakthrough in pharmacology, promising targeted delivery and reduction in drug toxicity. On the cellular level, encapsulation of a drug substantially affects the endocytic processes due to nanocarrier–membrane interaction. In this study we synthesized and characterized nanocarriers assembled from amphiphilic oligomers of N-vinyl-2-pyrrolidone with a terminal thiooctadecyl group (PVP-OD). It was found that the dissolution free energy of PVP-OD depends linearly on the molecular mass of its hydrophilic part up to M¯n = 2 × 104, le

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Karnwal, Arun, Vikas Sharma, Gaurav Kumar, Amar Yasser Jassim, Aradhana Dohroo, and Iyyakkannu Sivanesan. "Transforming Medicine with Nanobiotechnology: Nanocarriers and Their Biomedical Applications." Pharmaceutics 16, no. 9 (2024): 1114. http://dx.doi.org/10.3390/pharmaceutics16091114.

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Nanobiotechnology, at the intersection of nanotechnology and biology, represents a burgeoning field poised to revolutionize medicine through the use of advanced nanocarriers. These nanocarriers, endowed with distinctive physiobiological attributes, are instrumental in diverse therapeutic domains including drug delivery for microbial infections, cancer treatment, tissue engineering, immunotherapy, and gene therapy. Despite the transformative potential, several challenges hinder their efficacy, such as limited drug capacity, suboptimal targeting, and poor solubility. This review delves into the

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Kumar, Lalit, and Puneet Utreja. "Transcending the Cutaneous Barrier Through Nanocarrier Exploration for Passive Delivery of Anti-hypertensive Drugs: A Critical Review." Recent Patents on Nanotechnology 14, no. 3 (2020): 193–209. http://dx.doi.org/10.2174/1872210514666200519071734.

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Background: Hypertension comes under the category of chronic disease, which requires long term treatment. Hypertension is usually treated by oral administration of various therapeutic agents. There are several limitations of the oral route, making pharmaceutical scientists to discover an alternative route for drug delivery. Methods: The transdermal route may be a better alternative as it shows various advantages like lack of first-pass effect and high patient compliance. The skin may act as a primary barrier for the transdermal delivery of anti-hypertensive drugs; therefore, new approaches are

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Chen, Shuyan. "Advancement in Nanocarrier-Based Whitening Cosmetics: Mechanisms, Applications, and Future Prospects." Advances in Engineering Technology Research 13, no. 1 (2025): 1296. https://doi.org/10.56028/aetr.13.1.1296.2025.

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Demand for skin-whitening products driven by jittery is leading transmutation in cosmetics formulation, even more so with nanotechnology. The one responsible for the complexion is a splash of melanin, the overproduction of which leads to the major cause behind hyperpigmentation issues. This review illustrates the main mechanisms of skin lightening, different categories of nanocarrier-based whitening cosmetics, and alternative strategies to enhance the efficacy, stability as well as skin permeation of nanocarrier-based active compounds. In specific, this review discussed the advantages of vario

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Lombardo, Domenico, Mikhail A. Kiselev, and Maria Teresa Caccamo. "Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine." Journal of Nanomaterials 2019 (February 27, 2019): 1–26. http://dx.doi.org/10.1155/2019/3702518.

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The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic (including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic (including quantum dots, gold and mesoporous silica nanoparticles) materials. De

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Bernal-Chávez, S., M. G. Nava-Arzaluz, R. I. Y. Quiroz-Segoviano, and A. Ganem-Rondero. "Nanocarrier-based systems for wound healing." Drug Development and Industrial Pharmacy 45, no. 9 (2019): 1389–402. http://dx.doi.org/10.1080/03639045.2019.1620270.

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Nowag, Sabrina, and Rainer Haag. "pH-Responsive Micro- and Nanocarrier Systems." Angewandte Chemie International Edition 53, no. 1 (2013): 49–51. http://dx.doi.org/10.1002/anie.201308619.

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Zhao, Yamei, Wei Tian, Guang Yang, and Xiaodong Fan. "Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier." Beilstein Journal of Organic Chemistry 10 (November 18, 2014): 2696–703. http://dx.doi.org/10.3762/bjoc.10.284.

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In this paper, a novel, multifunctional polymer nanocarrier was designed to provide adequate volume for high drug loading, to afford a multiregion encapsulation ability, and to achieve controlled drug release. An amphiphilic, triblock polymer (ABC) with hyperbranched polycarbonsilane (HBPCSi) and β-cyclodextrin (β-CD) moieties were first synthesized by the combination of a two-step reversible addition-fragmentation transfer polymerization into a pseudo-one-step hydrosilylation and quaternization reaction. The ABC then self-assembled into stable micelles with a core–shell structure in aqueous s

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kumari, Dwarasala Lakshmi, Divya kandavalli, and Kantamaneni Padmalatha. "Advancing Nanocarrier-Based Drug Delivery: Precision." Trends in Pharmaceuticals and Nanotechnology 7, no. 2 (2025): 1–7. https://doi.org/10.46610/tpnt.2025.v07i02.001.

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Nanocarrier‐based drug delivery systems have emerged as a transformative approach in modern therapeutics by enabling precise, site‐specific drug release, enhanced bioavailability, and improved stability of therapeutic agents. These nanoscale platforms overcome many limitations of conventional formulations, including poor aqueous solubility, rapid clearance, and off‐target toxicity. In this review, we provide a comprehensive examination of various nanocarrier platforms including lipid‐based carriers, polymeric vehicles, dendrimers, inorganic nanoparticles, and hybrid assemblies. We discuss each

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Kenchegowda, Madhuchandra, Mohamed Rahamathulla, Umme Hani, et al. "Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review." Molecules 27, no. 1 (2021): 146. http://dx.doi.org/10.3390/molecules27010146.

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Cancer is a group of disorders characterized by uncontrolled cell growth that affects around 11 million people each year globally. Nanocarrier-based systems are extensively used in cancer imaging, diagnostics as well as therapeutics; owing to their promising features and potential to augment therapeutic efficacy. The focal point of research remains to develop new-fangled smart nanocarriers that can selectively respond to cancer-specific conditions and deliver medications to target cells efficiently. Nanocarriers deliver loaded therapeutic cargos to the tumour site either in a passive or active

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Fliedel, Louise, Khair Alhareth, Nathalie Mignet, Thierry Fournier, and Karine Andrieux. "Placental Models for Evaluation of Nanocarriers as Drug Delivery Systems for Pregnancy Associated Disorders." Biomedicines 10, no. 5 (2022): 936. http://dx.doi.org/10.3390/biomedicines10050936.

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Pregnancy-associated disorders affect around 20% of pregnancies each year around the world. The risk associated with pregnancy therapeutic management categorizes pregnant women as “drug orphan” patients. In the last few decades, nanocarriers have demonstrated relevant properties for controlled drug delivery, which have been studied for pregnancy-associated disorders. To develop new drug dosage forms it is mandatory to have access to the right evaluation models to ensure their usage safety and efficacy. This review exposes the various placental-based models suitable for nanocarrier evaluation f

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Bukhari, Sarah I., Syed Sarim Imam, Mohammad Zaki Ahmad, et al. "Recent Progress in Lipid Nanoparticles for Cancer Theranostics: Opportunity and Challenges." Pharmaceutics 13, no. 6 (2021): 840. http://dx.doi.org/10.3390/pharmaceutics13060840.

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Cancer is one of the major leading causes of mortality in the world. The implication of nanotherapeutics in cancer has garnered splendid attention owing to their capability to efficiently address various difficulties associated with conventional drug delivery systems such as non-specific biodistribution, poor efficacy, and the possibility of occurrence of multi-drug resistance. Amongst a plethora of nanocarriers for drugs, this review emphasized lipidic nanocarrier systems for delivering anticancer therapeutics because of their biocompatibility, safety, high drug loading and capability to simu

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Essa, Divesha, Yahya E. Choonara, Pierre P. D. Kondiah, and Viness Pillay. "Comparative Nanofabrication of PLGA-Chitosan-PEG Systems Employing Microfluidics and Emulsification Solvent Evaporation Techniques." Polymers 12, no. 9 (2020): 1882. http://dx.doi.org/10.3390/polym12091882.

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Poor circulation stability and inadequate cell membrane penetration are significant impediments in the implementation of nanocarriers as delivery systems for therapeutic agents with low bioavailability. This research discusses the fabrication of a biocompatible poly(lactide-co-glycolide) (PLGA) based nanocarrier with cationic and hydrophilic surface properties provided by natural polymer chitosan and coating polymer polyethylene glycol (PEG) for the entrapment of the hydrophobic drug disulfiram. The traditional emulsification solvent evaporation method was compared to a microfluidics-based met

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Chauhan, Dr Shikha Baghel, Astha Singh, and Indu Singh. "Cutting-Edge Developments in utilizing Lipid Nano-carrier for Enhanced Drug Delivery." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 5 (2024): 7614–27. https://doi.org/10.37285/ijpsn.2024.17.5.8.

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Nanocarriers have emerged as promising drug delivery systems due to their unique properties and capabilities. This abstract provides an overview of the concept of nanocarriers as drug delivery systems, highlighting their significance and potential applications. The report begins by introducing the background and significance of drug delivery systems. It emphasizes the limitations of conventional drug delivery methods and the need for more efficient and targeted approaches. Nanocarriers offer a solution to these challenges by providing controlled and targeted drug delivery, leading to improved

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Murugan, Baranya, Suresh Sagadevan, Is Fatimah, Won-Chun Oh, Mohd Abd Motalib Hossain, and Mohd Rafie Johan. "Smart stimuli-responsive nanocarriers for the cancer therapy – nanomedicine." Nanotechnology Reviews 10, no. 1 (2021): 933–53. http://dx.doi.org/10.1515/ntrev-2021-0067.

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Abstract Nanomedicine is ongoing current research in the applications of nanotechnology for cancer therapy. Simply from a technology perspective, this field of research has an enormous broadening and success to date. Recently, nanomedicine has also made inroads in the treatment of cancer. Stimuli-responsive nanoparticles are an emerging field of research because its targeting capacity is of great interest in the treatment of cancer. The responsive nanoparticles are efficient in encountering different internal biological stimuli (acidic, pH, redox, and enzyme) and external stimuli (temperature,

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Wang, Guan-Hai, Guo-Liang Huang, Yi Zhao, et al. "ATP triggered drug release and DNA co-delivery systems based on ATP responsive aptamers and polyethylenimine complexes." Journal of Materials Chemistry B 4, no. 21 (2016): 3832–41. http://dx.doi.org/10.1039/c5tb02764k.

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Moon, Yujeong, Hanhee Cho, and Kwangmeyung Kim. "Nano-Delivery of Immunogenic Cell Death Inducers and Immune Checkpoint Blockade Agents: Single-Nanostructure Strategies for Enhancing Immunotherapy." Pharmaceutics 16, no. 6 (2024): 795. http://dx.doi.org/10.3390/pharmaceutics16060795.

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Cancer immunotherapy has revolutionized oncology by harnessing the patient’s immune system to target and eliminate cancer cells. However, immune checkpoint blockades (ICBs) face limitations such as low response rates, particularly in immunologically ‘cold’ tumors. Enhancing tumor immunogenicity through immunogenic cell death (ICD) inducers and advanced drug delivery systems represents a promising solution. This review discusses the development and application of various nanocarriers, including polymeric nanoparticles, liposomes, peptide-based nanoparticles, and inorganic nanoparticles, designe

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Das, Dibash Kumar. "Nanocarrier Drug Delivery Systems for Colorectal Cancer." Oncology Times 43, no. 5 (2021): 22,27–27. http://dx.doi.org/10.1097/01.cot.0000737716.79578.f5.

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Mozafari, M. R., A. Pardakhty, S. Azarmi, J. A. Jazayeri, A. Nokhodchi, and A. Omri. "Role of nanocarrier systems in cancer nanotherapy." Journal of Liposome Research 19, no. 4 (2009): 310–21. http://dx.doi.org/10.3109/08982100902913204.

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Rana, Anita, Monika Matiyani, Pushpa Bhakuni Negi, et al. "Polyvinylpyrrolidone‐functionalized graphene oxide as a nanocarrier for dual‐drug delivery of quercetin and curcumin against HeLa cancer cells." Journal of Vinyl and Additive Technology, May 13, 2024. http://dx.doi.org/10.1002/vnl.22115.

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AbstractThis study is to develop a nanocarrier based on polyvinylpyrrolidone (PVP)‐functionalized graphene oxide (GO–PVP), loaded with both curcumin (CUR) and quercetin (QSR), and then its performance compared with nanocarriers carrying the drugs separately. The study also aimed to investigate the cytotoxic effects of these nanocarriers on HeLa cancer cells. To achieve this, GO was synthesized using a modified version of Hummer's method and subsequently functionalized with PVP. Drug loading onto the GO and GO–PVP nanocarriers was achieved through hydrophobic interactions. Furthermore, the abil

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Verma, Shivani, and Puneet Utreja. "Exploring Therapeutic Potential Of Invasomes, Transfersomes, Transethosomes, Oleic Acid Vesicles, And Cubosomes Adopting Topical/Transdermal Route." Micro and Nanosystems 13 (April 6, 2021). http://dx.doi.org/10.2174/1876402913666210406163452.

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Background: Transdermal drug delivery is considered as a better alternative to oral administration of drugs like proteins or peptides that are susceptible to extensive degradation via first pass metabolism. This delivery route also shows high patient compliance due to no use of painful injections. Conventional delivery systems like creams and gel show poor skin permeation and high dosing frequency. Objective: The objective of this work was to investigate the role of highly advanced micro and nanocarrier systems like invasomes, transfersomes, transethosomes, oleic acid vesicles, and cubosomes f

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Gao, Xuejiao J., Krzesimir Ciura, Yuanjie Ma, et al. "Toward the Integration of Machine Learning and Molecular Modeling for Designing Drug Delivery Nanocarriers." Advanced Materials, September 10, 2024. http://dx.doi.org/10.1002/adma.202407793.

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AbstractThe pioneering work on liposomes in the 1960s and subsequent research in controlled drug release systems significantly advances the development of nanocarriers (NCs) for drug delivery. This field is evolved to include a diverse array of nanocarriers such as liposomes, polymeric nanoparticles, dendrimers, and more, each tailored to specific therapeutic applications. Despite significant achievements, the clinical translation of nanocarriers is limited, primarily due to the low efficiency of drug delivery and an incomplete understanding of nanocarrier interactions with biological systems.

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Bhatia, Rohit, Amit Sharma, Raj Kumar Narang, and Ravindra K. Rawal. "Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy." Current Molecular Pharmacology 13 (July 30, 2020). http://dx.doi.org/10.2174/1874467213666200730114943.

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: Cancer is one of the most serious health concerns in 21st century whose prevalence is beyond boundaries and can affect any organ of human beings. The conventional chemotherapeutic treatment strategies lack specificity to tumours and are associated with toxic effects on immune system and other organ systems. In the past decades, there has been a continuous progress in the development of smart nanocarrier systems for target specific delivery of drugs against variety of tumours including intracellular gene-specific targeting. These nanocarriers are able to recognize the tumour cells and deliver

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Kulkarni, Samruddhi, Bala Prabhakar, and Pravin Shende. "Aquasomes: Advanced vesicular-based nanocarrier systems." Current Pharmaceutical Design 28 (July 28, 2022). http://dx.doi.org/10.2174/1381612828666220728112741.

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Background: Aquasomes are novel trilayered non-lipoidal vesicular nanocarriers that demonstrate structural similarity to ceramic nanoparticles with theranostic activity for diseases like ovarian cancer and antigen delivery. Objective: The objective of the present article is to highlight the multifaceted potential of aquasomes over other nanocarriers for the treatment of various treatments like hemophilia A, cancer, and hepatitis. Methods: Aquasomes enter the target cell by modifying the surface chemistry, extending drug release. The solid core of aquasomes provides structural stability whereas

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Shamim and Tarmeen Ali. "Chromatography and Spectroscopic Technique-Based Rapid Characterization of Nano-Carrier Pharmaceuticals." Pharmaceutical Nanotechnology 13 (October 21, 2024). http://dx.doi.org/10.2174/0122117385319695240911115239.

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A nanocarrier is a novel colloidal system whose particle size ranges between 1-100 nm. It is extensively utilized in drug delivery and various other sectors, such as the pharmaceutical, food, and dairy industries. The nanocarrier systems, including solid lipid nanoparticles, micelles, liposomes, and other encapsulated compounds, have improved stability, solubility, bioavailability, and quality. Nanocarriers offer therapeutic effectiveness with low toxicity because of their biocompatibility and ability to cross body barriers. Various analytical techniques, such as chromatography and spectroscop

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