Academic literature on the topic 'Nanoconfinement of drugs'

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Journal articles on the topic "Nanoconfinement of drugs"

1

Smruti, P. Chaudhari, and Gupte Anshul. "Mesoporous Silica as a Carrier for Amorphous Solid Dispersion." British Journal of Pharmaceutical Research 16, no. 6 (2017): 1–19. https://doi.org/10.9734/BJPR/2017/33553.

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In the past decade, the discovery of active pharmaceutical substances with high therapeutic value but poor aqueous solubility has increased, thus making it challenging to formulate these compounds as oral dosage forms. The bioavailability of these drugs can be increased by formulating these drugs as an amorphous drug delivery system. Use of porous media like mesoporous silica has been investigated as a potential means to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. These materials have nanosized capillaries and the large surface area whic
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Budiman, Arif, and Diah Lia Aulifa. "Characterization of Drugs with Good Glass Formers in Loaded-Mesoporous Silica and Its Theoretical Value Relevance with Mesopores Surface and Pore-Filling Capacity." Pharmaceuticals 15, no. 1 (2022): 93. http://dx.doi.org/10.3390/ph15010093.

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The incorporation of a drug into mesoporous silica (MPS) is a promising strategy to stabilize its amorphous form. However, the drug within MPS has shown incomplete release, despite a supersaturated solution being generated. This indicates the determination of maximum drug loading in MPS below what is experimentally necessary to maximize the drug doses in the system. Therefore, this study aimed to characterize the drugs with good glass former loaded-mesoporous silica, determine the maximum drug loading, and compare its theoretical value relevance to monolayer covering the mesoporous (MCM) surfa
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Kang, Changsun, and Dongin Kim. "Nanoconfinement-mediated cancer theranostics." Archives of Pharmacal Research 43, no. 1 (2020): 110–17. http://dx.doi.org/10.1007/s12272-020-01217-2.

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4

Salas-Zúñiga, Reynaldo, Karina Mondragón-Vásquez, Sergio Alcalá-Alcalá, et al. "Nanoconfinement of a Pharmaceutical Cocrystal with Praziquantel in Mesoporous Silica: The Influence of the Solid Form on Dissolution Enhancement." Molecular Pharmaceutics 19, no. 2 (2021): 414–31. http://dx.doi.org/10.1021/acs.molpharmaceut.1c00606.

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Xiong, Tao, Yang Zhang, Nader Amin, and Jin-Chong Tan. "A Luminescent Guest@MOF Nanoconfined Composite System for Solid-State Lighting." Molecules 26, no. 24 (2021): 7583. http://dx.doi.org/10.3390/molecules26247583.

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A series of rhodamine B (RhB) encapsulated zeolitic imidazolate framework-8 (RhB@ZIF-8) composite nanomaterials with different concentrations of guest loadings have been synthesized and characterized in order to investigate their applicability to solid-state white-light-emitting diodes (WLEDs). The nanoconfinement of the rhodamine B dye (guest) in the sodalite cages of ZIF-8 (host) is supported by fluorescence spectroscopic and photodynamic lifetime data. The quantum yield (QY) of the luminescent RhB@ZIF-8 material approaches unity when the guest loading is controlled at a low level: 1 RhB gue
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Martínez, Alejandra A., Aurelien Gasnier, and Fabiana C. Gennari. "From Iron to Copper: The Effect of Transition Metal Catalysts on the Hydrogen Storage Properties of Nanoconfined LiBH4 in a Graphene-Rich N-Doped Matrix." Molecules 27, no. 9 (2022): 2921. http://dx.doi.org/10.3390/molecules27092921.

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Incipient wetness impregnation was employed to decorate two N-doped graphene-rich matrixes with iron, nickel, cobalt, and copper nanoparticles. The N-doped matrix was wetted with methanol solutions of the corresponding nitrates. After agitation and solvent evaporation, reduction at 800 °C over the carbon matrix promoted the formation of nanoparticles. The mass of the metal fraction was limited to 5 wt. % to determine if limited quantities of metallic nanoparticles catalyze the hydrogen capture/release of nanoconfined LiBH4. Isotherms of nitrogen adsorption afforded the textural characterizatio
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Gotzias, Anastasios. "Umbrella Sampling Simulations of Carbon Nanoparticles Crossing Immiscible Solvents." Molecules 27, no. 3 (2022): 956. http://dx.doi.org/10.3390/molecules27030956.

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We use molecular dynamics to compute the free energy of carbon nanoparticles crossing a hydrophobic–hydrophilic interface. The simulations are performed on a biphasic system consisting of immiscible solvents (i.e., cyclohexane and water). We solvate a carbon nanoparticle into the cyclohexane layer and use a pull force to drive the nanoparticle into water, passing over the interface. Next, we accumulate a series of umbrella sampling simulations along the path of the nanoparticle and compute the solvation free energy with respect to the two solvents. We apply the method on three carbon nanoparti
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Klonos, Panagiotis A., Alexandra Evangelopoulou, Zoi Terzopoulou, et al. "Revisiting Non-Conventional Crystallinity-Induced Effects on Molecular Mobility in Sustainable Diblock Copolymers of Poly(propylene adipate) and Polylactide." Molecules 27, no. 21 (2022): 7449. http://dx.doi.org/10.3390/molecules27217449.

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This work deals with molecular mobility in renewable block copolymers based on polylactide (PLA) and poly(propylene adipate) (PPAd). In particular, we assess non-trivial effects on the mobility arising from the implementation of crystallization. Differential scanning calorimetry, polarized light microscopy and broadband dielectric spectroscopy were employed in combination for this study. The materials were subjected to various thermal treatments aiming at the manipulation of crystallization, namely, fast and slow cooling, isothermal melt- and cold-crystallization. Subsequently, we evaluated th
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Jin, Huixian, Yun Zeng, Zhikun Shang, et al. "Synthesis of cyclometaphenylene under nanoconfinement and further derivatization." Tetrahedron Letters, August 2023, 154679. http://dx.doi.org/10.1016/j.tetlet.2023.154679.

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