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Journal articles on the topic 'Nanoemulsions preparation'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Singh, Pragati, Somya Khanna, and Ekta Singh Chauhan. "Nanoemulsion: Composition, Preparation and its Application in the Food Industry." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 3 (2024): 7398–405. http://dx.doi.org/10.37285/ijpsn.2024.17.3.9.

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Nanotechnology deals with the application of atoms, molecules, or macromolecules with sizes ranging from 1 to 100 nm to create and utilize materials with distinct and novel characteristics. Nanotechnology has gained popularity over the past few decades and is now widely regarded as a revolutionary technology in the food industry. Various nanoencapsulation techniques have been spawned by the boom in interest in nanotechnology and its application in food products. One of the most exciting encapsulating and delivering methods in the food sector is nanoemulsion. A nanoemulsion is a mixture of two

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2

Mammedova, P., M. Valiyeva, and A. Agamalieva. "PREPARATION OF NANO-EMULSION ON THE BASIS OF NAFTALAN OIL BY MODERN TECHNOLOGY." Sciences of Europe, no. 111 (February 27, 2023): 22–27. https://doi.org/10.5281/zenodo.7680284.

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The scientific article analyzes the advantages and disadvantages of various methods for obtaining nanoemulsions, discusses and considers promising areas of their use. For the first time, a nanoemulsion based on naphthalan oil has been obtained. The optimal parameters influencing the preparation of the obtained nanoemulsion were studied: temperature regime, mixing speed and time. A technology for the preparation of nanoemulsions based on naphthalan oil has been experimentally proposed. The modern dilution method revealed the type of flat nanoemulsion developed by us for the first time.

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3

Oliyaei, Najmeh, Marzieh Moosavi-Nasab, and Nader Tanideh. "Preparation of Fucoxanthin Nanoemulsion Stabilized by Natural Emulsifiers: Fucoidan, Sodium Caseinate, and Gum Arabic." Molecules 27, no. 19 (2022): 6713. http://dx.doi.org/10.3390/molecules27196713.

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This study was proposed to investigate the possibility of O/W nanoemulsion stabilization via natural emulsifiers as a delivery system for fucoxanthin. Nanoemulsions were prepared using ultrasonic treatment (150 W, amplitude 80%, 10 min) with different levels (0.5%, 1%, and 2% wt) of fucoidan, gum Arabic, and sodium caseinate as natural emulsifires and they were compared with tween 80. Then, the creaming index, stability, encapsulation efficacy, Fourier-transform infrared (FT-IR) spectroscopy, and in vitro release were evaluated. The best stability and lowest creaming index were observed at 2%

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4

Sabjan, Khaleel Basha, Syed Muzammil Munawar, Dhandayuthabani Rajendiran, Sugantha Kumari Vinoji, and Kaviyarasu Kasinathan. "Nanoemulsion as Oral Drug Delivery - A Review." Current Drug Research Reviews 12, no. 1 (2020): 4–15. http://dx.doi.org/10.2174/2589977511666191024173508.

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Background: Objective:: The stability and delivery of drugs remain one of the key hurdles in the present situation. The present study depends on the design of a novel nanoemulsion drugdelivery system that would encapsulate a drug and to improve drug stability. The charisma of nanotechnology is majorly due to the smallest particle size at the nanoscale. Methods: Nanoemulsions attention is focused on emphasizing formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nanoemulsions, several techniques to be used for the preparati

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Ayesha Rauf, Muhammad Jamshaid, Mahmood Ahmad, and Irfan Bashir. "Retinoid based nanoemulsions: Preparation to therapeutic applications." Journal of Contemporary Pharmacy 4, no. 2 (2021): 44–47. http://dx.doi.org/10.56770/jcp2020424.

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Modern mode of drug delivery system has been constructed to defeat the main issues linked with the traditional drug delivery system. This particular review will give an idea about the retinoid based nanoemulsion system. The main focus is to briefly explain the different aspects of nanoemulsion formulations, procedure of preparation, portrayal procedures with special focus on different utilizations of nanoemulsion in various area. Nanoemulsions are colloidal dispersion system that are composed of two non-miscible mixtures mixed along with surfactants and co-surfactants emulsifier to develop a s

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6

Changediya, Vaibhav V., Rupalben Jani, and Pradip Kakde. "A Review on Nanoemulsions: A Recent Drug Delivery Tool." Journal of Drug Delivery and Therapeutics 9, no. 5 (2019): 185–91. http://dx.doi.org/10.22270/jddt.v9i5.3577.

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There is a growing interest for using of nano/sub-micron particles in the technology of pharmaceutical, cosmetic and also food. Especially, this interest has been increasing parallel with better emulsification techniques and stabilization mechanisms. There are two main groups of nanoemulsion preparation methods, namely high-energy and low-energy spontaneous emulsification methods. Preparation processes and components used are significant parameters that affect stability from few hours to years. Problems such as creaming, coalescence sedimentation and flocculation are not concern for nanoemulsi

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Mulia, Kamarza, Gitasha Afiyah Putri, and Elsa Krisanti. "Encapsulation of Mangosteen Extract in Virgin Coconut Oil Based Nanoemulsions: Preparation and Characterization for Topical Formulation." Materials Science Forum 929 (August 2018): 234–42. http://dx.doi.org/10.4028/www.scientific.net/msf.929.234.

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Nanoemulsions containing extract of mangosteen (Garcinia mangostana L.) rind has been developed and characterized as a topical formulation. The encapsulation of mangosteen extract in nanoemulsions is considered a promising strategy to utilize the available bioactive compounds, particularly α-mangostin. In this study, a high-speed homogenization method was used to produce nanoemulsions of virgin coconut oil as the oil phase, combined Tween 80 and Span 80 as the oil-in-water surfactant, and distilled water as the aqueous phase. The homogenizer speed, oil and surfactant composition, and, hydrophi

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Kumar, Ashish, Ajay Kumar, Abhishek Soni, and Jyoti Devi. "Development and In-Vitro Evaluation of Itraconazole Loaded Nanoemulsion." Journal of Drug Delivery and Therapeutics 12, no. 3 (2022): 31–42. http://dx.doi.org/10.22270/jddt.v12i3.5317.

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Nanoemulsions are one of the major popular formulation systems in the pharmaceutical and cosmeceutical fields. Nanoemulsions are generally composed of a dispersed oil phase within a continuous aqueous phase. Itraconazole is an antifungal medication used to treat a number of fungal infections. It is in the triazole family of medications. Itraconazole, antifungal agent has poor bioavailability due to low aqueos solubility. In this research preformulation study, Fourier transform infrared (FTIR) analysis studies was conducted for studying the compatibility. In preparation of Itraconazole loaded n

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9

Jin, Tiancheng. "Development and Application of the Nanoemulsions in Drug Delivery Systems." Highlights in Science, Engineering and Technology 125 (February 18, 2025): 86–92. https://doi.org/10.54097/byef6n27.

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Nanoparticle drug delivery systems (NDDS) have emerged as a promising alternative to traditional drug delivery methods, offering significant improvements in drug bioavailability, targeting, and reduced toxicity. Among these, nanoemulsions (NE) have shown considerable potential across various therapeutic applications, addressing the limitations of conventional drug delivery systems. This review explores the preparation methods, characterization techniques, and advantages of nanoemulsions in drug delivery. Key preparation methods, including ultrasonic emulsification, high-pressure homogenization

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Asmawi, Azren Aida, Norazlinaliza Salim, Emilia Abdulmalek, and Mohd Basyaruddin Abdul Rahman. "Size-Controlled Preparation of Docetaxel- and Curcumin-Loaded Nanoemulsions for Potential Pulmonary Delivery." Pharmaceutics 15, no. 2 (2023): 652. http://dx.doi.org/10.3390/pharmaceutics15020652.

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Lung cancer is one of the deadliest pulmonary diseases in the world. Although docetaxel (DTX) has exhibited superior efficacy in lung cancer treatment, it has demonstrated numerous adverse effects and poor bioavailability. The natural product extract, curcumin (CCM), has reportedly reduced toxicity and synergistically improved DTX bioavailability. Nonetheless, the hydrophobic nature of DTX and CCM limits their clinical use. Nanoemulsion pulmonary delivery of DTX and CCM has demonstrated potential as a drug carrier to alleviate these drawbacks. The controlled preparation of inhalable DTX- and C

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Bidita, B. S., Suraya Abdul Rashid, Azni B. Idris, and Mohamad Amran Mohd Salleh. "Emission Characteristics of Water in Diesel Nanoemulsions in Diesel Engine." Advanced Materials Research 832 (November 2013): 248–53. http://dx.doi.org/10.4028/www.scientific.net/amr.832.248.

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Nanoemulsions are a class of nanomaterials which play an increasingly important role in commercial and environmental aspects. Water-in-diesel (W/D) nanoemulsion is considered one of the environmental friendly alternative fuels for reducing the emission pollution of internal combustion engine such as diesel engines. In this context, a study has been made to evaluate the combustion characteristics of W/D nanoemulsion fuel. A wide range of surfactant concentration (0.25% to 0.40% v/v) with varying amount of water percentage (0.5% to 0.8% v/v) was used in the preparation of W/D nanoemulsion fuel.

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12

Anuchapreeda, Songyot, Yoshinobu Fukumori, Siriporn Okonogi, and Hideki Ichikawa. "Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy." Journal of Nanotechnology 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/270383.

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The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonication. Soybean oil, hydrogenatedL-α-phosphatidylcholine from egg yolk, and cosurfactants were used to formulate the emulsions. The resultant nanoemulsions showed mean particle diameter of 47–55 nm, could incorporate 23–28 mg curcumin per 30 mL, and were stable in particle size for 60 days at 4°C. Th

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Prajapati, Bhupendra G., Akshay Parihar, Mercy Macwan, and Swati Pal. "A comprehensive review on applications, preparation & characterization of nanoemulsion." IP International Journal of Comprehensive and Advanced Pharmacology 8, no. 2 (2023): 104–11. http://dx.doi.org/10.18231/j.ijcaap.2023.018.

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With time, dosage forms have progressed, from essential tablets to advanced systems, which are now more focused on providing better ease of administration to the patients. One such advantageous novel drug delivery system is Nanoemulsion based drug delivery. The Nanoemulsion-based system is reasonably a new means of enhancing drug delivery; Nanoemulsions are sub-micron size particles roughly in the size range of 50-600 nm. The review focuses on conveying information by combining various articles and study reports to understand the work done in this field. This review paper aims to serve as a to

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Wik, Johanna, Kuldeep K. Bansal, Tatu Assmuth, Ari Rosling, and Jessica M. Rosenholm. "Facile methodology of nanoemulsion preparation using oily polymer for the delivery of poorly soluble drugs." Drug Delivery and Translational Research 10, no. 5 (2019): 1228–40. http://dx.doi.org/10.1007/s13346-019-00703-5.

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AbstractAqueous solubility of an active pharmaceutical ingredient (API) is a determining factor that has a direct impact on formulation strategies and overall bioavailability. Fabrication of nanoemulsions of poorly soluble drugs is one of the widely utilized approaches to overcome this problem. However, thermodynamic instability and tedious manufacturing processes of nanoemulsions limit their clinical translation. Therefore, this study was focused on circumventing the abovementioned hurdles by utilizing the polymer as an oil phase, instead of conventional oils. The nanoemulsion was prepared vi

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Liu, Huang, Chen, Lin, and Wang. "Food-Grade Nanoemulsions: Preparation, Stability and Application in Encapsulation of Bioactive Compounds." Molecules 24, no. 23 (2019): 4242. http://dx.doi.org/10.3390/molecules24234242.

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Nanoemulsions have attracted significant attention in food fields and can increase the functionality of the bioactive compounds contained within them. In this paper, the preparation methods, including low-energy and high-energy methods, were first reviewed. Second, the physical and chemical destabilization mechanisms of nanoemulsions, such as gravitational separation (creaming or sedimentation), flocculation, coalescence, Ostwald ripening, lipid oxidation and so on, were reviewed. Then, the impact of different stabilizers, including emulsifiers, weighting agents, texture modifiers (thickening

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16

R, Prakasha, Vinay G M, Pathiam Srilatha, and Hridyesh Pandey. "Nanoemulsions as Carriers of Bioactive Compounds in Functional Foods: Preparation and Application." European Journal of Nutrition & Food Safety 17, no. 1 (2025): 78–95. https://doi.org/10.9734/ejnfs/2025/v17i11621.

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Nanoemulsions, characterised by their small droplet size and kinetically stable colloidal systems, are gaining widespread attention in the food industry. Their composition and structure can be precisely tailored to encapsulate and deliver bioactive lipophilic compounds effectively. In recent years, there have been significant advancements in the development of nanoemulsions, employing various approaches to achieve specific functional properties. These nanoemulsions play a pivotal role in preserving and enhancing the functionality and stability of bioactive components such as vitamins, antioxid

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17

Ghazali, N. S. M., and R. Zakaria. "Preparation of essential oil nanoemulsions and its incorporation in chitosan-based edible coating on guava." Food Research 9, Supplementary 1 (2025): 133–45. https://doi.org/10.26656/fr.2017.9(s1).089.

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Nanoemulsions possess powerful nano-scale properties that make them attractive for diverse applications. In this work, two types of essential oil, namely clove essential oil (CEO) and lemon essential oil (LEO), were formulated into nanoemulsions using a highpressure homogeniser (HPH). The essential oils were mixed with virgin coconut oil (VCO) at different formulations to stabilise the oil from the coalition effect. The characterisation of nanoemulsions produced was done by observing the appearance of the nanoemulsions and analysing the droplet size and the stability of the nanoemulsions durin

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Nahdhia, Nadhifatun, M. Agus Syamsur Rijal, Esti Hendradi, and Riyanto Teguh Widodo. "Application of the Simplex Lattice Design Method to Determine the Optimal Formula of Diclofenac Sodium Nanoemulsion." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 11, no. 2 (2024): 137–46. https://doi.org/10.20473/jfiki.v11i22024.137-146.

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Background: The success of nanoemulsion preparation, with the aim of producing good characteristic values, is determined by the ratio of each component. The design of experiments (DoE) approach using the Simplex Lattice Design (SLD) method can be used to determine the optimal formula for nanoemulsions, with variable factors consisting of oleic acid, Tween 20:ethanol (4:1), and water. The observed response variables included droplet size, PDI, and pH. Objective: DoE can help reduce the energy, cost, and time needed to make the optimal formula for diclofenac sodium nanoemulsions. Methods: Nanoem

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Krishnamoorthy, Rajapandiyan, Hany M. Yehia, Meera Moydeen Abdul Hameed, et al. "Ultrasonic-assisted food grade nanoemulsion preparation from clove bud essential oil and evaluation of its antioxidant and antibacterial activity." Green Processing and Synthesis 11, no. 1 (2022): 974–86. http://dx.doi.org/10.1515/gps-2022-0083.

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Abstract Nanoemulsions formulated using materials of the highest food grade are receiving significant attention in various industries, especially food-based applications. Food-grade nanoemulsions are suitable for delivering bioactive molecules and their bioavailability, encapsulation, and protection. The present study aimed to extract essential oil (EO) from clove bud and formulate food-grade nanoemulsions. Furthermore, it investigated antioxidant and antimicrobial efficacy of nanoemulsions against foodborne pathogens. The present study found that the extracted clove bud EO is enriched with po

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Purwandari, Vivi, Artha Yuliana Sianipar, Yosy Cinthya Eriwaty Silalahi, and Dinda Juita Nasution. "UJI EFEKTIVITAS ANTIBAKTERI NANO GEL BAHAN AKTIF EKSTRAK KAYU MANIS (Cinnamomum burmannii) TERHADAP Staphylococcus aureus." JURNAL FARMANESIA 7, no. 2 (2020): 37–44. http://dx.doi.org/10.51544/jf.v7i2.2776.

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Nanogel preparations consist of nanoemulsions and gels, where nanoemulsion is one type of preparation that can increase drug permeability on the membrane surface. The use of cinnamon extract as an antibacterial active substance is because cinnamon (Cinnamomum burmannii) contains saponins, tannins, and flavonoids. This study aims to make nanogel preparations with the active ingredient of cinnamon extract and to determine the antibacterial effectiveness of the nanogel as the active ingredient of the cinnamon extract against Staphylococcus aureus. The manufacture of 2% cinnamon extract nanoemulsi

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Li, Ze-En, Yang-Guang Jin, Shao-Zu Hu, et al. "Design, Optimization, Manufacture and Characterization of Milbemycin Oxime Nanoemulsions." Pharmaceutics 17, no. 3 (2025): 289. https://doi.org/10.3390/pharmaceutics17030289.

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Background: Despite the rapid development of nanoemulsions in recent years, no method has been established for the preparation of milbemycin oxime nanoemulsions. Milbemycin oxime is a widely used macrolide antibiotic in veterinary medicine, particularly for treating parasitic infections in animals such as dogs. However, its poor solubility in water limits its bioavailability and therapeutic efficacy. Developing a nanoemulsion formulation can enhance its solubility, stability, and bioavailability, offering a more effective treatment option. Methods: In this experiment, oil-in-water (O/W) milbem

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Arianto, Anayanti, and Cindy Cindy. "Preparation and Evaluation of Sunflower Oil Nanoemulsion As a Sunscreen." Open Access Macedonian Journal of Medical Sciences 7, no. 22 (2019): 3757–61. http://dx.doi.org/10.3889/oamjms.2019.497.

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BACKGROUND: There are a lot of different types of sunscreen products (oils, sticks, gels, creams, lotions) which can be found on the world's market. Sunscreen product that contains active chemical ingredients sometimes has harmful effects on the skin. Sunflower oil contains vitamin E and acts as a natural sunscreen which can absorb UVB light. The average droplet size of nanoemulsion is between 100 and 500 nm and do not show the problems of stability (creaming, flocculation, coalescence, and sedimentation), which are commonly associated with macroemulsions. AIM: The aim of this study was

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Amoros-Cerón, Zayra Yeretzi, Juan Manuel Pinos-Rodríguez, Hugo Sergio García, Angélica Olivares-Muñoz, Isaac De Gasperin-López, and Argel Flores-Primo. "Effect of Nanoemulsions of Betulinic Acid on the Development of Canine Mammary Tumors." Veterinary Sciences 12, no. 6 (2025): 522. https://doi.org/10.3390/vetsci12060522.

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Mammary gland tumors in dogs are very common in clinical practice. Betulinic acid is currently a compound considered to have anticancer properties in human mammary tumors via nanoemulsions. In this study, betulinic acid nanoemulsions with a particle size of less than 300 nm were prepared. Biopsies were obtained from five female dogs with mammary tumors for histopathological analysis, confirming that two were tubular mammary carcinomas (MMTs, malignant) and three were complex mammary adenomas (BMTs, benign). The five female dogs were administered with a daily oral dose of nanoemulsion containin

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Shaikh, Neha M. Vijayendra Swamy S. M. Nagoba Shivappa N.* Shaikh Atiya L. "A REVIEW ON CURRENT TRENDS OF NANOEMULSION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 721–32. https://doi.org/10.5281/zenodo.2536245.

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<em>The Nanoemulsions have the potential in pharmaceutical industries because of the transparency at high droplet volume fraction, higher rate of bioavailability or diffusion and increased shelf life of the pharmaceuticals. </em><em>Nanoemulsions are submicron sized emulsions that are under investigation as drug carriers for improving the delivery of therapeutic agents. These are clear, thermodynamically stable, isotropic liquid mixtures of oil, water, surfactant and co-surfactant. Reduction in droplet size to nanoscale leads to change in physical properties such as optical transparency and un

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Shaikh, Neha M. Vijayendra Swamy S. M. Nagoba Shivappa N.* Shaikh Atiya L. "A REVIEW ON CURRENT TRENDS OF NANOEMULSION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 721–32. https://doi.org/10.5281/zenodo.2536278.

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<em>The Nanoemulsions have the potential in pharmaceutical industries because of the transparency at high droplet volume fraction, higher rate of bioavailability or diffusion and increased shelf life of the pharmaceuticals. </em><em>Nanoemulsions are submicron sized emulsions that are under investigation as drug carriers for improving the delivery of therapeutic agents. These are clear, thermodynamically stable, isotropic liquid mixtures of oil, water, surfactant and co-surfactant. Reduction in droplet size to nanoscale leads to change in physical properties such as optical transparency and un

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Hou, Nian-Ting, and Bing-Huei Chen. "Preparation of Nanoemulsions with Low-Molecular-Weight Collagen Peptides from Sturgeon Fish Skin and Evaluation of Anti-Diabetic and Wound-Healing Effects in Mice." Pharmaceutics 15, no. 9 (2023): 2304. http://dx.doi.org/10.3390/pharmaceutics15092304.

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This study aims to isolate collagen peptides from waste sturgeon fish skin, and prepare nanoemulsions for studying their anti-diabetic and wound-healing effects in mice. Collagen peptides were extracted and purified by acetic acid with sonication, followed by two-stage hydrolysis with 0.1% pepsin and 5% flavourzyme, and ultrafiltration with 500 Da molecular weight (MW) cut-off dialysis membrane. Animal experiments were performed with collagen peptides obtained by pepsin hydrolysis (37 kDa) and pepsin plus flavourzyme hydrolysis (728 Da) as well as their nanoemulsions prepared at two different

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Ronak, Kumar Rabadiya*1 Divya Gupta2 Chainesh Shah3 Umesh Upadhyay4. "Nanoemulsions: A Promising Technology For The Development Of Innovative Products." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 709–19. https://doi.org/10.5281/zenodo.13759881.

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Nanoemulsions are submicron-sized emulsions under extensive investigation as drug carriers for improving the delivery of therapeutic agents. They are the most advanced nanoparticle systems for the systemic delivery of biologically active agents for controlled drug delivery and targeting. Nanoemulsions are thermodynamically stable isotropic systems formed by mixing two immiscible liquids (water and oil) with suitable surfactants or their mixture to obtain a single phase with a droplet diameter ranging from 0.5 to 100 um. The size distributions of nanoemulsion droplets are narrow and usually lie

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Nevase, C.M. Phadtare S.S. "An overview on Nanoemulsion Drug Delivery Systems." International Journal of Pharma Research and Technology 1, no. 3 (2022): 7–13. https://doi.org/10.5281/zenodo.7646206.

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The nanoemulsion, with droplet sizes ranging from submicron to micron, is one of the most effective dispersed nanosystems. Thermodynamically stable transparent or translucent dispersions of oil and water known as nanoemulsions, sub-micron emulsions (SMEs), and mini-emulsions are held together by an interfacial coating of surfactant and cosurfactant molecules with a droplet size of less than 100 nm.. These appear to be ultrafine dispersions with variable levels of drug loading, viscoelastic properties, and aesthetic characteristics that can be used for a variety of purposes, including drug admi

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Tunkam, Papitchaya, and Chutimon Satirapipathkul. "Preparation of Nanoemulsion from Sacha Inchi Oil/Water by Emulsion Phase Inversion Methods." Key Engineering Materials 675-676 (January 2016): 57–60. http://dx.doi.org/10.4028/www.scientific.net/kem.675-676.57.

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The aim of this study was to develop a nanoemulsion of Sacha inchi oil for cosmetic application by the emulsion phase inversion (EPI) method. The influence of surfactant type and surfactant-to-oil ratio (SOR) on the particle size distributions of the nanoemulsion was studied. The results obtained showed that nanoemulsion droplet size, and stability of nanoemulsions were varied considerably. At optimal condition, the smallest size (41.43 ± 0.12 nm.) and high zeta potential values were obtained

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Jamali, Seyedeh Narges, Elham Assadpour, and Seid Mahdi Jafari. "Formulation and Application of Nanoemulsions for Nutraceuticals and Phytochemicals." Current Medicinal Chemistry 27, no. 18 (2020): 3079–95. http://dx.doi.org/10.2174/0929867326666190620102820.

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: Recent trends in research and investigation on nanoemulsion based products is the result of many reasons such as food security as a global concern, increasing demand for highly efficient food and agricultural products and technological need for products with the ability of manipulation and optimization in their properties. Nanoemulsions are defined as emulsions made up of nano sized droplets dispersed in another immiscible liquid which exhibit properties distinguishing them from conventional emulsions and making them suitable for encapsulation, delivery and formulations of bioactive ingredie

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Gang, Qiu, and Rui Yapei. "Preparation of Eprinomectin Nanoemulsions and Determination of Their Pharmacokinetics and Pharmacodynamics in Dairy Cows." Journal of Biomedical Nanotechnology 18, no. 2 (2022): 512–26. http://dx.doi.org/10.1166/jbn.2022.3268.

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This study aimed to develop an anthelmintic that leaves no residues and is safe and efficient for use in cows. We constructed classical pseudoternary phase diagrams using experimental animal data to optimize and characterize the eprinomectin nanoemulsion formulas. The emulsion samples prepared with ethyl acetate, polysorbate 80, and 1-propanediol as the main components were transparent and uniform when observed under a Hitachi transmission electron microscope (TEM) system. A Mastersizer 3000 laser particle size analyzer was used to determine the particle sizes of the prepared nanoemulsions. Th

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Charamcharla, Bhanu Chandu, Koti Veeranagaiah K., Y. N. V. Pavan Kumar Varma Datla, Sai Manoj Varma Sagiraju, and Rao Vadapalli* Rama. "A REVIEW ON PREPARATION AND EVALUATION OF NANOEMULSION." World Journal of Pharmaceutical Science and Research 3, no. 6 (2024): 122–29. https://doi.org/10.5281/zenodo.14252569.

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Nanoemulsion Considers a novel drug delivery System that permits Controlled or sustained drug release. It is a dispersion consisting of a Surfactant, oil, and clear aqueous phase. Kinetically, or thermodynamically stable, droplet diameter 10-100mm. Nanoemulsion applied to increase the Solubility and bioavailability of Lipophilic drug. This review provides brief information about method of preparation and evaluation of nanoemulsion as drug Carriers for improving the delivery of therapeutic agents. Several techniques are to be used for preparation of Nanoemulsions Like High pressure homogenizati

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Lin, Yu-Hsiang, Chi-Chung Wang, Ying-Hung Lin, and Bing-Huei Chen. "Preparation of Catechin Nanoemulsion from Oolong Tea Leaf Waste and Its Inhibition of Prostate Cancer Cells DU-145 and Tumors in Mice." Molecules 26, no. 11 (2021): 3260. http://dx.doi.org/10.3390/molecules26113260.

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Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice. Catechin nanoemulsions composed of lecithin, Tween-80 and water in an appropriate proportion was prepared with high stability, particle size of 11.3 nm, zeta potential of −67.2 mV and encapsulation efficiency of 83.4%. Catechin nanoemulsions were more effective than extracts in inhibiting DU-145 cell growth, with the IC50 being 13.52 and 214.6 μg/mL, respectively, after 48 h incubation. Furthermore, both catechin nanoemulsions and ext

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Widyastuti, Alvira Intan, and Dwi Saryanti. "Formulasi dan Evaluasi Sediaan Nanoemulsi Ekstrak Umbi Bawang Putih (Allium sativum L.)." Jurnal Sains dan Kesehatan 5, no. 2 (2023): 178–85. http://dx.doi.org/10.25026/jsk.v5i2.1677.

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Garlic bulbs (Allium sativum L.) has an active substance in the form of allicin which is thermolabil, allicin as the main antioxidant that can prevent free radicals. Nanoemulsion has a particle size of 20-500 nm which is an oil and water dispersion system stabilized by a combination of surfactant and cosurfactant. The purpose of this study was to obtain the best formula from the variation of VCO concentration 3%, 5%, 8% and determine the stability of nanoemulsion preparations. Nanoemulsions are formulated in oil phase VCO, surfactant Tween 80, and cosurfactant PEG 400. Nanoemulsion preparation

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Hamed, S. F., and G. A. Abo-Elwafa. "Preparation of novel nanoemulsions from omega-3 rich oil." Grasas y Aceites 71, no. 2 (2020): 350. http://dx.doi.org/10.3989/gya.0229191.

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This work aimed to produce stabilized omega-3-rich oil in a water nanoemulsion using a high-pressure homogenizer (HPH). Studies were carried out on the effects of the type of the emulsifier and its concentration, HPH conditions (pressure and number of passes inside the homogenization chamber) as well as continuous phase viscosity on the polydispersity index (PDI) and mean droplet size of the nanoemulsion were carried out. The impact of rosemary extract on the oxidative stability of the emulsion was also monitored. Results showed that small molecular weight emulsifiers gave small droplet size

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Niknam, Seyed Mehdi, Mansoore Kashaninejad, Isabel Escudero, María Teresa Sanz, Sagrario Beltrán, and José M. Benito. "Preparation of Water-in-Oil Nanoemulsions Loaded with Phenolic-Rich Olive Cake Extract Using Response Surface Methodology Approach." Foods 11, no. 3 (2022): 279. http://dx.doi.org/10.3390/foods11030279.

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In this study, we aimed to prepare stable water-in-oil (W/O) nanoemulsions loaded with a phenolic-rich aqueous phase from olive cake extract by applying the response surface methodology and using two methods: rotor-stator mixing and ultrasonic homogenization. The optimal nanoemulsion formulation was 7.4% (w/w) of olive cake extract as the dispersed phase, and 11.2% (w/w) of a surfactant mixture of polyglycerol polyricinoleate (97%) and Tween 80 (3%) in Miglyol oil as the continuous phase. Optimum results were obtained by ultrasonication for 15 min at 20% amplitude, yielding W/O nanoemulsion dr

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Chaiyana, Wantida, Jirasit Inthorn, Suvimol Somwongin, et al. "The Fatty Acid Compositions, Irritation Properties, and Potential Applications of Teleogryllus mitratus Oil in Nanoemulsion Development." Nanomaterials 14, no. 2 (2024): 184. http://dx.doi.org/10.3390/nano14020184.

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This study aimed to characterize and investigate the potential of the oils from Gryllus bimaculatus, Teleogryllus mitratus, and Acheta domesticus to be used in nanoemulsions. The oils were extracted by a cold press method and characterized for their fatty acid profiles. Their irritation effects on the chorioallantoic membrane (CAM) were evaluated, along with investigations of solubility and the required hydrophilic–lipophilic balance (RHLB). Various parameters impacting nanoemulsion generation using high-pressure homogenization were investigated. The findings revealed that G. bimaculatus yield

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Ghavidel, Fatemeh, Afshin Javadi, Navideh Anarjan, and Hoda Jafarizadeh-Malmiri. "New approach in process intensification based on subcritical water, as green solvent, in propolis oil in water nanoemulsion preparation." Green Processing and Synthesis 10, no. 1 (2021): 208–18. http://dx.doi.org/10.1515/gps-2021-0022.

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Abstract Subcritical water was used to provide propolis oil in water (O/W) nanoemulsions. To monitor and detect the main bioactive compounds of the prepared propolis extract, gas chromatography demonstrated that there were 47 bioactive materials in the propolis extract, among which pinostrobin chalcone and pinocembrin were the two key components. Effectiveness of two processing parameters such as the amount of saponin (0.5–2.0 g) and propolis extract (0.1–0.6 g), on particle size, polydispersity index (PDI), zeta potential, and antioxidant activity of the provided nanoemulsions, was evaluated.

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Tontul, İsmail. "Gıda Bileşenlerinin Enkapsülasyonunda Nanoemülsiyonların Kullanımı." Turkish Journal of Agriculture - Food Science and Technology 8, no. 1 (2020): 130. http://dx.doi.org/10.24925/turjaf.v8i1.130-138.2877.

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The increase in consumers' demands for safer and healthier food has led to the development of many new products in food technology. For this reason, micro- or nanoencapsulation has become an important area in order to protect food components with functional properties against environmental conditions and to provide controlled release in recent years. As a matter of fact, many encapsulation techniques have been developed and many different active materials have been encapsulated. Nanoemulsions, a nanoencapsulation technique, are the process of encapsulating core material in two immiscible liqui

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Mirkovic, Dusica, and Svetlana Ibric. "Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions." Vojnosanitetski pregled 77, no. 7 (2020): 688–96. http://dx.doi.org/10.2298/vsp180115140m.

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Background/Aim. The application of nanoemulsions (NE) in parenteral nutrition represents a very important advancement that marked the medicine and pharmacy of the twentieth century. Over the years, the technology of the production of NE and total parenteral nutrition (TPN) nanoemulsions or admixtures has undergone constant improvement. Representing the continuation of the previous research, this paper deals with nanoemulsions in a concentration of 20% that were prepared under laboratory conditions. The main emphasis was put on the possibility of detecting the potential presence of large drople

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Zeng, Liya, Yongchang Liu, Zhihui Yuan, and Zhe Wang. "Formation and Physical Stability of Zanthoxylum bungeanum Essential Oil Based Nanoemulsions Co-Stabilized with Tea Saponin and Synthetic Surfactant." Molecules 26, no. 24 (2021): 7464. http://dx.doi.org/10.3390/molecules26247464.

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The purpose of this work was to evaluate the possibility of adding tea saponin (TS) to reduce the synthetic surfactant concentration, and maintain or improve the shelf stability of nanoemulsions. The Zanthoxylum bungeanum essential oil (2.5 wt%) loaded oil-in-water nanoemulsions were co-stabilized by Tween 40 (0.5–2.5 wt%) and TS (0.1–5 wt%). A combination of several analytical techniques, such as dynamic laser scattering, interfacial tension, zeta potential, and transmission electron microscope, were used for the characterization of nanoemulsions. Low levels of TS (0.1–0.5 wt%) with Tween 40

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Varshosaz, J., S. Andalib, M. Tabbakhian, and N. Ebrahimzadeh. "Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol through Rat Skin." Journal of Nanomaterials 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/139437.

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Background. Drugs with low oral bioavailability due to the first pass metabolism are good candidates for transdermal delivery.Objectives.The aim of this work was preparation of transdermal nanoemulsion of metoprolol which has high first pass metabolism.Methods. Three commercially available types of lecithin (200, 100p, and 170), three short chain alcohol (n-butanol, isopropyl alcohol, and n-propanol), and isopropyl myristate (IPM) were used as surfactant, cosurfactant, and oil phase, respectively. The aqueous phase was composed of metoprolol tartrate. Nanoemulsions with different surfactant/co

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Hasan, Hafiz Mahmood, Jiraporn Leanpolchareanchai, and Anchalee Jintapattanakit. "Preparation of Virgin Coconut Oil Nanoemulsions by Phase Inversion Temperature Method." Advanced Materials Research 1060 (December 2014): 99–102. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.99.

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Presently, the low energy emulsification method; phase inversion temperature (PIT) method offers a convenient mean of nanoemulsion formation for the incorporation of fragile substances. The aim of the current study was to prepare coconut oil nanoemulsions using cremophor RH 40 as nonionic surfactant in the light of PIT method. The suitable composition of coconut oil, cremophor RH40 and water was investigated by construction of ternary phase diagram. The PIT of system can be adjusted to 75 °C by adding NaCl at the concentration of 6%(w/w). Stable translucent nanoemulsions with particle size in

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Prasad, Dasari, G. P. Mohanta, and M. Sudhakar. "A Review on Preparation and Evaluation of Nanoemulsions." International Journal of Pharma Research and Health Sciences 7, no. 1 (2019): 2915–22. http://dx.doi.org/10.21276/ijprhs.2019.01.11.

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Petralito, Stefania, Stefania Garzoli, Elisa Ovidi, et al. "Long-Term Stability of Lavandula x intermedia Essential Oil Nanoemulsions: Can the Addition of the Ripening Inhibitor Impact the Biocidal Activity of the Nanoformulations?" Pharmaceutics 16, no. 1 (2024): 108. http://dx.doi.org/10.3390/pharmaceutics16010108.

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In this work, Lavandula x intermedia essential oil (LEO) was encapsulated in lipid-based nanoemulsions (NanoLEO) using the solvent-displacement technique. In order to preserve the colloidal stability of the formulation, LEO was appropriately doped with the incorporation of different levels of a water-insoluble oil used as a ripening inhibitor. All the nanoemulsion samples were evaluated in terms of the impact of the water-insoluble oil on the nanoemulsion formation, physical–chemical properties, and antibacterial effectiveness against E. coli (Gram-negative) and B. cereus (Gram-positive). The

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Li, Rui, Baskaran Stephen Inbaraj, and Bing-Huei Chen. "Quantification of Xanthone and Anthocyanin in Mangosteen Peel by UPLC-MS/MS and Preparation of Nanoemulsions for Studying Their Inhibition Effects on Liver Cancer Cells." International Journal of Molecular Sciences 24, no. 4 (2023): 3934. http://dx.doi.org/10.3390/ijms24043934.

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Mangosteen peel, a waste produced during mangosteen processing, has been reported to be rich in xanthone and anthocyanin, both of which possess vital biological activities such as anti-cancer properties. The objectives of this study were to analyze various xanthones and anthocyanins in mangosteen peel by UPLC-MS/MS for the subsequent preparation of both xanthone and anthocyanin nanoemulsions to study their inhibition effects on liver cancer cells HepG2. Results showed that methanol was the optimal solvent for the extraction of xanthones and anthocyanins, with a total amount of 68,543.39 and 29

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Kumar, Girish, Tarun Virmani, Kamla Pathak, and Abdulsalam Alhalmi. "A Revolutionary Blueprint for Mitigation of Hypertension via Nanoemulsion." BioMed Research International 2022 (April 14, 2022): 1–12. http://dx.doi.org/10.1155/2022/4109874.

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Hypertension is one of the most important causes of mortality, affecting the health status of the patient. At the same time, hypertension causes a huge health and economic burden on the whole world. The incidence and prevalence of hypertension are rising even among young people in both urban as well as rural communities. Although various conventional therapeutic moieties are available for the management of hypertension, they have serious flaws such as hepatic metabolism, reduced dose frequency, poor aqueous solubility, reduced bioavailability, and increased adverse effects, making the drug the

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Algahtani, Mohammed S., Mohammad Zaki Ahmad, and Javed Ahmad. "Investigation of Factors Influencing Formation of Nanoemulsion by Spontaneous Emulsification: Impact on Droplet Size, Polydispersity Index, and Stability." Bioengineering 9, no. 8 (2022): 384. http://dx.doi.org/10.3390/bioengineering9080384.

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Interest in nanoemulsion technology has increased steadily in recent years for its widespread applications in the delivery of pharmaceuticals, nutraceuticals, and cosmeceuticals. Rational selection of the composition and the preparation method is crucial for developing a stable nanoemulsion system with desired physicochemical characteristics. In the present study, we investigate the influence of intricate factors including composition and preparation conditions that affect characteristic parameters and the stability of the nanoemulsion formation prepared by the spontaneous emulsification metho

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Yuliani, S., K. Wahyuningsih, Hernani, et al. "Spontaneous Emulsification of Citronella Oil: Effect of Processing Conditions and Production Scale." IOP Conference Series: Earth and Environmental Science 1172, no. 1 (2023): 012053. http://dx.doi.org/10.1088/1755-1315/1172/1/012053.

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Abstract Nanoemulsions are gaining considerable interest for use in delivery of essential oil-based pesticides. Evaluation in the laboratory have shown promising efficacy of nanobiopesticides, and further development in nanoemulsion production at larger scale is needed for a wider application in the field. This study aimed to evaluate the changes in droplet size characteristics of citronella oil nanoemulsions produced using spontaneous emulsification at increased scales. The preparation of nanoemulsion was carried out in two stages of scale-up, namely the laboratory scale (200–1000 mL) and the

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Kim, Tae-Il, Tae-Gyun Kim, Dong-Hyun Lim, et al. "Preparation of Nanoemulsions of Vitamin A and C by Microfluidization: Efficacy on the Expression Pattern of Milk-Specific Proteins in MAC-T Cells." Molecules 24, no. 14 (2019): 2566. http://dx.doi.org/10.3390/molecules24142566.

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In this study, we prepared stabilized vitamin A and C nanoemulsions, and investigated their efficacy on milk-specific proteins in bovine mammary epithelial cells (MAC-T). Emulsions of vitamin A (vit-A) and C (vit-C) were prepared using Lipoid S 75 and microfluidization. The particle size and polydispersity index (PDI) of nanoemulsified vit-A and vit-C were studied. The cytotoxic effect of nanoemulsion-free and nanoemulsified vit-A and vit-C was determined by an MTT assay. In addition, the efficacy of nanoemulsified vit-A and vit-C on the in vitro expression pattern of milk-specific proteins in

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