Journal articles: 'Nanofiltrace'

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Kedang, Yohana Ivana. "Membran Nanofiltrasi untuk Aplikasi Pemisah Zat." Jurnal Saintek Lahan Kering 2, no. 1 (June 30, 2019): 27–29. http://dx.doi.org/10.32938/slk.v2i1.444.

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Mekanisme pemisahan nanofiltrasi sebagian besar didasarkan pada ukuran dan perbedaan tingkat difusi untuk molekul organik dan efek elektrostatik untuk ion. Namun, karena molekul yang tidak bermuatan lebih banyak, mekanisme berdasarkan ukuran molekul lebih banyak digunakan. Membran nanofiltrasi beroperasi tanpa perubahan fasa dan biasanya memiliki penolakan tinggi terhadap garam anorganik multivalen dan molekul organik kecil pada tekanan sedang. Hal ini membuat proses pemisahan sangat kompetitif dalam hal selektifitas dan biaya bila dibandingkan dengan perpisahan tradisional. Membran nanofiltrasi telah diaplikasikan di berbagai sektor industri yaitu pengolahan air limbah, proses farmasi dan bioteknologi, serta rekayasa pangan. Artikel ini diharapkan dapat memberikan ide dan rekomendasi mengenai inovasi pembuatan membran nanofiltrasi untuk pemisah limbah zat warna.

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Nugroho, Andriono Sapto. "UJI KINERJA MEMBRAN NANOFILTRASI ZEOLIT UNTUK MENAPIS NITRAT DAN AMONIUM AIR LIMBAH PRODUKSI TAHU." Jurnal Purifikasi 14, no. 2 (July 26, 2014): 106–17. http://dx.doi.org/10.12962/j25983806.v14.i2.16.

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Tujuan dari penelitian ini adalah mengidentifikasi proses sintesis serta karakteristik membran nanofiltrasi dengan bahan baku zeolit alam secara spesifik serta mencari efektifitas kinerja zeolit sebagai membran nanofiltrasi untuk menurunkan kadar nitrat dan amonium dalam limbah cair tahu yang ada di Surabaya. Metode yang digunakan dalam mengurangi bahkan menghilangkan nitrat dan amonium serta dapat mengoptimalkannya, adalah dengan menentukan ukuran partikel zeolit 40 mesh serta durasi proses centrifuge selama 10 menit dengan penambahan NH4Cl sebagai porogen dan penambahan lapisan pendukung PEG 400 sebagai kekuatan membran. Kinerja membran zeolit nanofiltrasi sangat baik dan efektif dalam menapis nitrat dan amonium, dimana permeabilitas membran zeolit nanofiltrasi tertinggi pada ukuran partikel 40 mesh dengan durasi centrifuge 10 menit dengan nilai 3.81 L/m2.jam serta permselektivitas membran zeolit tertinggi dalam menapis nitrat pada ukuran partikel 40 mesh dengan durasi centrifuge10 menit dengan nilai 57.72% pada volume limbah 25% sedangkan permselektivitas membran zeolit tertinggi dalam menapis amonium pada ukuran partikel 40 mesh dengan durasi 10 menit dengan nilai 98.18% pada volume limbah 75%.

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Dudziak, Mariusz, Klaudiusz Grübel, and Mariusz Kuglarz. "THE SEQUENTIAL WATER TREATMENT CONTAINING MYCOESTROGENS IN PHOTOCATALYSIS AND NANOFILTRATION PROCESSES." Inżynieria Ekologiczna 32 (2013): 32–39. http://dx.doi.org/10.12912/23920629/364.

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Kedang, Yohana Ivana. "Review: Karakterisasi dan Modifikasi Membran Poliamida untuk Aplikasi Pemisahan Zat Warna." Jurnal Saintek Lahan Kering 1, no. 2 (December 23, 2018): 28–30. http://dx.doi.org/10.32938/slk.v1i2.568.

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Membran nanofiltrasiterjadi akibat proses perbedaan tekanan untuk memisahkan solut berukuran lebih besar dari larutan. Membran inidigunakan pada proses pemurnian air, seperti pelunakan air, penghilangan zat warna, dan penghilangan mikropolutan. Membran memiliki beberapa kriteria yang penting untuk menentukan kinerja membran sebagai filtrasi yakni parameter fluks (permeabilitas), rejeksi (permselektivitas), ketebalan, morfologi dan sifat mekanik membran. Artikel ini diharapkan dapat memberikan ide dan rekomendasi mengenai karakterisasi membran serta pembuatan membran nanofiltrasi menggunakan modifikasi membran poliamida.

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Ciptaraharja, Iman, and Veronica S. Praptowidodo. "Membran nonofiltrasi untuk penghilangan ion valensi tinggi dan senyawa organik dari sumber air salinitas tinggi." Jurnal Teknik Kimia Indonesia 5, no. 3 (October 2, 2018): 478. http://dx.doi.org/10.5614/jtki.2006.5.3.3.

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Utilization of nanofiltration membrane for high valence ion and organic compound removing from high salinized water source.The influence of solvent selection to membrane morphology for cellulose acetate nanofiltration membrane preparation in mass transfer of a multistage reverse osmosis process is studied. Membrane is prepared via precipitation immersion technique. The polymer used in this study is cellulose acetate (CA) with a concentration of 25 %-w. The feed concentration of univalent ion solution (NaCl) is varied between 2000-16.000 mg/L. The operating pressure is adjusted such that the operating pressure is three times of the osmotic pressure of NaCl solution. The concentration of bivalent ion (CaCl2), trivalent ion (FeCl3), and organic substance (glucose) are 200 mg/L, 50 mg/L, and 100 mg/L, respectively. The morphology of the membrane is characterized using Scanning Electron Microscopy (SEM). Membrane CA-01 (CA/DMF/Water) is a nanofiltration membrane with a thinner active layer and a more porous support layer than membrane CA-02 (CA/Aceton/Watter) which is categorized as a reverse osmosis membrane. A reduced feed concentration (at a fixed operating pressure) gives an elevated flux however the rejection is decreased. Meanwhile, an elevated operating pressure (at a fixed feed concentration) gives an elevated flux and rejection. Membrane CA-01 has met the requirement as a nanofiltration membrane since it gives 66 % rejection for NaCl at 20 Bar. At the same operating pressure, membrane CA-01 gives rejection for CaCl2, FeCl3, and glucose of 80.45%, 82.14%, and 83.42%, respectively.Keywords: Cellulose Acetate, Membrane, Multistage, Nanotiltration, Reverse Osmosis, Saline WaterAbstrakPenelitian ini dilakukan untuk mempelajari pengaruh jenis pelarut dalam pembuatan membran nanofiltrasi dari polimer selulosa asetat terhadap struktur morfologi membran dalam peristiwa perpindahan massa pada proses pemisalan osmosis balik multitahap. Teknik pembuatan membran yang digunakan adalah presipitasi imersi. Polimer membran yang digunakan adalah seulosa asetat (CA) pada konsentrasi 25 %-berat. Umpan yang digunakan adalah larutan ion valensi satu (NaCl) dengan variasi konsentrasi antara 2000 hingga 16.000 mg/L. Tekanan operasi diatur sedemikian rupa sehingga nilai rekanan operasi adalah sekitar tiga kali tekanan osmotik larutan NaCl. Percobaan juga dilakukan untuk umpan larutan ion valensi dua (CaCl2), ion valensi tiga (FeCl3), dan senyawa organik (glukosa) dengan konsentrasi, berturut-turut, adalah 200 mg/L, 50 mg/L, dan 100 mg/L. Struktur morfologi membran diuji menggunakan metoda Scanning Electron Microscopy (SEM). Membran CA-01 (CA/DMF/Air) merupakan membran nanofiltrasi dengan lapisan aktif yang lebih tipis dan ukuran pori lapisan penyangga yang lebih besar daripada membran CA-02 (CA/Aseton/Air), yang termasuk ke dalam membran osmosis balik. Penurunan konsentrasi umpan pada tekanan operasi yang tetap memberikan nilai fluks yang meningkat, namun memberikan nilai rejeksi yang menurun. Sementara itu, peningkatan tekanan operasi pada konsentrasi umpan yang tetap akan memberikan nilai fluks dan rejeksi yang meningkat. Membran CA-01 telah memenuhi persyaratan sebagai membran nanofiltrasi dengan rejeksi NaCl mencapai 66 % pada tekanan 20 Bar. Pada tekanan yang sama membran CA-01 memberikan nilai rejeksi untuk CaCl2, FeCl3, dan glukosa berturut-turut sebesar 80,45%, 82,14%, dan 83,42 %.Kata Kunci: Air Salinitas Tinggi, Membran, Multitahap, Nanofiltrasi, Osmosis Balik, Selulosa Asetat.

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Al-Jlil, S. "Performance of nano-filtration and reverse osmosis processes for wastewater treatment." Materiali in tehnologije 51, no. 3 (June 2, 2017): 541–48. http://dx.doi.org/10.17222/mit.2015.250.

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Greve, Jens, Janina Hahn, Melanie Nordmann, Patrick J. Schuler, Murat Bas, Thomas K. Hoffmann, Zuzana Hajdu, Maria Buchberger, and Ulrich Strassen. "Nanofiltrated C1-esterase-inhibitor in the prophylactic treatment of bradykinin-mediated angioedema." Transfusion 56, no. 5 (January 12, 2016): 1022–29. http://dx.doi.org/10.1111/trf.13462.

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Dudziak, Mariusz, and Edyta Burdzik-Niemiec. "THE INFLUENCE OF WATER MATRIX ON THE SEPARATION OF SELECTED ESTROGENS AND XENOESTROGENS BY NANOFILTRATION." Inżynieria Ekologiczna 18, no. 1 (February 1, 2017): 27–35. http://dx.doi.org/10.12912/23920629/65858.

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Sáenz, C., H. Gómez, A. M. Fabry, B. Cancino, C. Vergara, and R. Paz. "SOFT-DRINKS PREPARED WITH PULP, ULTRAFILTRATED AND NANOFILTRATED PURPLE CACTUS PEAR MICROPARTICLES: BETALAINS STABILITY." Acta Horticulturae, no. 1067 (January 2015): 343–48. http://dx.doi.org/10.17660/actahortic.2015.1067.47.

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Pabinger-Fasching, Ingrid. "Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate." Thrombosis Research 122 (January 2008): S19—S22. http://dx.doi.org/10.1016/s0049-3848(08)70005-7.

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Rahayu, Iman, Rustaman Rustaman, Anni Anggraeni, Atiek Rostika Noviyanti, and Rubianto A. Lubis. "PENGARUH TEKANAN DAN SUHU TERHADAP REJEKSI Gd-DTPA DAN Sm-DTPA DENGAN MENGGUNAKAN MEMBRAN NANOFILTRASI." Chimica et Natura Acta 4, no. 3 (December 12, 2016): 147. http://dx.doi.org/10.24198/cna.v4.n3.10926.

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12

Hidayah, Malikhatul. "Pengolahan Air Limbah Menjadi Air Minum Dengan Menghilangkan Amonium Dan Bakteri E-Coli Melalui Membran Nanofiltrasi." Walisongo Journal of Chemistry 1, no. 1 (June 2, 2018): 6. http://dx.doi.org/10.21580/wjc.v2i1.2668.

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Industrial waste water area that flows in the River Flood Canal Semarang can affect the environment if not done processing. Membrane is one alternative water treatment technologies with the principle of filtration. The presence of fouling is a problem encountered in the use of the membrane. In this study will be made of non-fouling nanofiltration membranes made from cellulose acetate. Manufacture of cellulose acetate membrane is accomplished by phase inversion method, which is changing the shape of the polymer solid phase into the liquid phase rich in solvent into solids (membrane) which is rich in polymer. Therefore, the aim of this study was to create a non-fouling nanofiltration membrane using cellulose acetate polymer as well as assess the effect of PEG additives and pre-treatment with UV light to the surface of the structure and performance of cellulose acetate membranes for produced water treatment. Research using cellulose acetate membranes for wastewater treatment is done by varying the type of PEG 1500 and 4000, variations of PEG of 1, 3 and 5% by weight and a UV irradiation for 10, 20 and 30 seconds. The research followed by testing the performance of the membrane in wastewater treatment using a dead-end filtration with the parameters of flux and rejection. Characterization of the membrane was analyzed with SEM and FTIR. Analysis of the results was conducted to determine the levels of turbidity, TDS, COD, Ca2+, S2- and oil in waste water before and after passing through the membrane.

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Kainulainen, T., T. Tuhkanen, T. Vartiainen, H. Heinonen-Tanski, and P. Kalliokoski. "The effect of different oxidation and filtration processes on the molecular size distribution of humic material." Water Science and Technology 30, no. 9 (November 1, 1994): 169–74. http://dx.doi.org/10.2166/wst.1994.0471.

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The effect of different oxidation and filtration processes on the amount and character of organic matter in drinking water was studied. TOC, KMnO4 value, colour and fractions of humic material were analyzed from bank filtrated lake water, chemically coagulated and sand filtrated water, ozonated, O3/H2O2 treated, chlorinated, granular activated carbon (GAC) filtrated and nanofiltrated water. Size exclusion chromatography was used to separate different fractions of humic molecules. Six different fractions were found from bank filtrated lake water and from chemically coagulated and sand filtrated water. The molecular weight of humic fractions ranged from about 1000 (the last fraction) to about 100 000 dalton (the first fraction). Most of the humic molecules of bank filtrated lake water were found in the third and fourth fractions. After the oxidation and filtration processes the first fraction of humic molecules disappeared completely and the fourth and fifth fractions dominated. The total sum of the humic fractions was most effectively reduced after the O3/H2O2 treatment, by about 70%.

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Sausan, Fida Warad, Ainun Rahma Puspitasari, and Dian Yanuarita P. "Studi Literatur Pengolahan Warna pada Limbah Cair Industri Tekstil Menggunakan Metode Proses Adsorpsi, Filtrasi, dan Elektrolisis." JURNAL TECNOSCIENZA 5, no. 2 (April 1, 2021): 213. http://dx.doi.org/10.51158/tecnoscienza.v5i2.427.

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Warna pada limbah cair indusri tekstil dihasilkan berasal proses pewarnaan. Limbah cair yang berwarna ini jika di buang langsung akan menghambat proses transfer oksigen dibadan air. Tujuan dari studi literatur ini adalah mengetahui waktu kontak dan media penyerap yang terbaik pada metode adsorpsi, filtrasi dan elektrolisis dalam pengolahan warna pada limbah cair industri tekstil. Metode adsorpsi, filtrasi dan elektrolisis adalah metode yang sering digunakan pada pengolahan warna pada limbah cair industri tekstil. Berdasarkan studi literatur yang telah dilakukan didapatkan hasil waktu kontak optimum dan media penyerap yang terbaik pada metode adsorpsi menggunakan media penyerap biosorben selama 30 menit mampu menyerap warna dengan efesiensi penyerapan 99,9%, metode filtrasi menggunakan media penyerap membran nanofiltrasi selama 480 menit mampu menyerap warna dengan efesiensi penyerapan 99,9% dan meode elektrolisis menggunakan media penyerap elektroda PbO2, Al, C selama 120 menit mampu menyerap warna dengan efesiensi penyerapan 99,78%. Kata kunci: Zat warna, Limbah Cair Industri Tekstil, Adsorpsi, Filtrasi, Elektrolisis, Persen Removal Warna

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Hanke, A. A., C. Joch, and K. Görlinger. "Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P/N): a pharmacovigilance study." British Journal of Anaesthesia 110, no. 5 (May 2013): 764–72. http://dx.doi.org/10.1093/bja/aes501.

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Kurniawan, Ian, and Pra Dian Mariadi. "REVIEW : PROFIL HYBRID MEMBRANE DALAM PROSES REDUKSI AIR LIMBAH." JURNAL KONVERSI 5, no. 1 (April 10, 2015): 1. http://dx.doi.org/10.24853/konversi.5.1.1-10.

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Frekuensi penggunaan air sangat tinggi seiring dengan perkembangan teknologi dan pertumbuhan jumlah penduduk. Peningkatan standar hidup manusia yang semakin tinggi menimbulkan permasalahan lingkungan terkait dengan kualitas air akibat bahan kimia, nutrisi, lindi, tumpahan minyak, pembuangan limbah bahan berbahaya, serta penggunaan bahan dispossable dan non-biodegradable. Perkembangan sumber daya teknologi menghasilkan suatu revolusi sehingga menghasilkan lebih banyak bahan dan senyawa kimia. sejumlah senyawa yang diidentifikasi memiliki ancaman potensial terhadap organisme lingkungan hidup. Tujuan penelitian ini adalah mengidentifikasi teknik pengolahan air limbah dengan menggabungkan dua sifat membran dalam mereduksi air limbah. Metode yang digunakan adalah review dari beberapa sumber pustaka dengan melakukan studi literatur terdahulu terhadap beberapa penelitian yang pernah dilakukan. Kesimpulan dari penelitian menghasilkan bahwa teknologi membran sebagai salah satu instalasi unit pengolahan limbah perkembangan dan kemajuannya sangat menjanjikan dan banyak dilakukan dalam proses dengan prinsip pemisahan dan pemurnian air. Teknologi membran bisa menjadi solusi dalam pengolahan air limbah, seiring dengan perkembangannya membran dapat dikombinasikan (Hybrid Process) dengan menggunakan berbagai jenis membrane yaitu Ultrafiltrasi, Mikrofiltrasi, Nanofiltrasi dan Reverse Osmosis, akan tetapi harus diperhatikan kondisi operasional dari proses tersebut. Kata kunci: air limbah, hybrid membrane, reduksi

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Boudin, Mathieu, Pascal Boeckx, Peter Vandenabeele, and Mark Van Strydonck. "Improved radiocarbon dating for contaminated archaeological bone collagen, silk, wool and hair samples via cross-flow nanofiltrated amino acids." Rapid Communications in Mass Spectrometry 27, no. 18 (August 13, 2013): 2039–50. http://dx.doi.org/10.1002/rcm.6652.

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Ohkouchi, Y., Y. Yata, R. Bun, and S. Itoh. "Chlorine requirement for biologically stable drinking water after nanofiltration." Water Supply 14, no. 3 (November 23, 2013): 405–13. http://dx.doi.org/10.2166/ws.2013.214.

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There is considerable interest in minimizing the chlorine residual in Japan's tap water because of increasing consumer complaints about the chlorinous odor of drinking water. However, minimization of the chlorine residual requires stricter control of biodegradable organics in finished water to ensure biological stability during water distribution. In this context, we investigated the improvement of biological stability of drinking water by nanofiltration (NF). The removal of assimilable organic carbon (AOC) was 52% on average, but showed large seasonal variation. It was found to be difficult to maintain the acceptable AOC level for biologically stable water by NF. In addition, significant bacterial regrowth in NF permeates was still observed without chlorination, although 52% AOC was removed. Then, the chlorine concentration required to prevent bacterial regrowth during distribution of nanofiltrated water was determined using continuous-flow reactor systems. The heterotrophic plate counts (HPC) densities in biofilm were monitored at different chlorine conditions. The results indicated that the NF process could significantly reduce the chlorine requirement of the finished water. The relationship between free chlorine residual and HPC in biofilm formed from 1 μgC AOC showed that a trace level of chlorine residual, <0.1 mg/L, could inactivate heterotrophic bacteria and prevent biofilm formation.

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Ernst, M., and M. Jekel. "Advanced Treatment Combination for Groundwater Recharge of Municipal Wastewater by Nanofiltration and Ozonation." Water Science and Technology 40, no. 4-5 (August 1, 1999): 277–84. http://dx.doi.org/10.2166/wst.1999.0601.

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This paper presents the results of research undertaken on an advanced treatment combination for polishing municipal wastewater with the purpose of a safe groundwater recharge. The results of a former study of DWQC initiated this research. It is envisaged that tertiary effluent is nanofiltrated to reject dissolved organic carbon (DOC) and adsorbable organic halogens (AOX) to concentrations less than 2–3 mg DOC/L respectively <2 μg AOX/L. The brine will be given back in a recycling process to the sewage treatment plant after passing an oxidation step. To avoid rising scaling potentials and other negative impacts due to increasing salinity, the rejection characteristics of several NF-membranes were investigated. They show a strong dependence between DOC and sulfate removal. Biofouling on the membrane surface (Desal DK5) can be controlled by higher cross-flow velocities (CFV) of about 1 m/s, however, a suitable pre-treatment like slow sand filtration is required. High water conversion factors result in moderately higher biofouling. This shows that water quality is the main factor responsible for fouling and not the concentration of constituents. Ozonation experiments with the concentrate confirmed an enhanced biodegradability of refractory DOC. At a specific ozone consumption 1,7 mg O3/mg DOC0 the DOC reduction by micro-organisms (aerobic biotest) reaches its maximum after 14 days of biodegradation with a total reduction of 60%.

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Khramtsov, A. G., and V. N. Sergeev. "Technological breakthrough of the agrarian-and-food innovations in dairy case for example of universal agricultural raw materials. Nanofiltration." Agrarian-And-Food Innovations 12 (December 25, 2020): 7–19. http://dx.doi.org/10.31208/2618-7353-2020-12-7-19.

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Aim. Consideration nanofiltration as a process of membrane technology – directed and controlled filtration of whey through special semipermeable partitions (membrane filters) with a pore size of 1-5 nm, carried out at a pressure of 0.7-4.0 MPa with the release of particles with a molecular weight of 0.5-1.0 kDa. Discussion. Nanofiltration allows you to separate the whey as a system by the size of the components – microparticles and macromolecules. In this case, from pre – separated, processed by microfiltration and ultrafiltration of whey to nanoconcentrate (retentate) pass almost all the compounds of whey, and in nanofiltrate (permeate) - only monovalent ions of mineral salts and partially some organic acids. Nanofiltration, in the logistics of molecular sieve separation of whey, takes over from ultrafiltration and is a harbinger of reverse osmosis. The theoretical foundations of the nanofiltration process are developed at a fairly good level. The basic element of the process is the membranes. Based on the conducted research, we can recommend the nanofiltration process for industrial processing of salted whey into milk sugar (lactose) and for concentrating whey and its ultrafiltrates before electrodialysis or ion exchange desalination. Nanofiltration is already widely used in the production of high-quality lactose (milk sugar). Considerable interest nanofiltration cottage cheese (acid) whey with the purpose of concentration, demineralization and sensory nanoconcrete for the enrichment of ice cream. Conclusion. Nanofiltration can be quite reasonably used for processing, within the framework of the Technological Breakthrough, universal agricultural raw materials – for example, whey and its ultrafiltrates – for the purpose of concentration, directed demineralization, lowering the level of organic acids and controlling sensorics. The resulting nanoconcentrate (retentate) can be used to scale functional products.

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Boudin, Mathieu, Pascal Boeckx, Peter Vandenabeele, and Mark van Strydonck. "An Archaeological Mystery Revealed by Radiocarbon Dating of Cross-Flow Nanofiltrated Amino Acids Derived from Bone Collagen, Silk, and Hair: Case Study of the Bishops Baldwin I and Radbot II from Noyon-Tournai." Radiocarbon 56, no. 2 (2014): 603–17. http://dx.doi.org/10.2458/56.16951.

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Excavations in the cathedral of Tournai revealed two sepultures, which were identified by the excavators as those of bishops because of their special location in the cathedral. One burial was assigned to Baldwin I, who died in AD 1068, because (1) a ring with the inscription “BAL” was found and (2) a funeral stone with text was present on top of the grave mentioning the name Baldewinus. The second burial probably belongs to Radbot II, who was the successor of Baldwin I, and died in AD 1098. Both burials contained textiles (silk), the skeleton, a wooden pastoral staff, and human hair was still present on the skull of what was presumed to be Radbot II. All the protein-containing materials were degraded and/or contaminated. Standard sample pretreatment methods were not able to remove all the contaminants. Single and double cross-flow nanofiltration of the hydrolyzed protein-containing materials were performed. The sample quality for radiocarbon dating was improved and14C data revealed interesting and surprising results. The14C dates of the wooden pastoral staff and permeate femur confirm that the skeleton and tomb belong to bishop Baldwin I. The14C dates of hair and permeate skull indicate that the skeleton may indeed belong to bishop Radbot II. The younger14C dates of the wooden pastoral staff and silk samples indicate a postburial disturbance of the site burial during the 12th–13th century.

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Boudin, Mathieu, Pascal Boeckx, Peter Vandenabeele, and Mark van Strydonck. "An Archaeological Mystery Revealed by Radiocarbon Dating of Cross-Flow Nanofiltrated Amino Acids Derived from Bone Collagen, Silk, and Hair: Case Study of the Bishops Baldwin I and Radbot II from Noyon-Tournai." Radiocarbon 56, no. 02 (2014): 603–17. http://dx.doi.org/10.1017/s0033822200049651.

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Excavations in the cathedral of Tournai revealed two sepultures, which were identified by the excavators as those of bishops because of their special location in the cathedral. One burial was assigned to Baldwin I, who died in AD 1068, because (1) a ring with the inscription “BAL” was found and (2) a funeral stone with text was present on top of the grave mentioning the name Baldewinus. The second burial probably belongs to Radbot II, who was the successor of Baldwin I, and died in AD 1098. Both burials contained textiles (silk), the skeleton, a wooden pastoral staff, and human hair was still present on the skull of what was presumed to be Radbot II. All the protein-containing materials were degraded and/or contaminated. Standard sample pretreatment methods were not able to remove all the contaminants. Single and double cross-flow nanofiltration of the hydrolyzed protein-containing materials were performed. The sample quality for radiocarbon dating was improved and14C data revealed interesting and surprising results. The14C dates of the wooden pastoral staff and permeate femur confirm that the skeleton and tomb belong to bishop Baldwin I. The14C dates of hair and permeate skull indicate that the skeleton may indeed belong to bishop Radbot II. The younger14C dates of the wooden pastoral staff and silk samples indicate a postburial disturbance of the site burial during the 12th–13th century.

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Nakar, Charles T., Roberto Caputo, Francis W. Price, Maria Teresa Sartori, Andrea Leonardi, Anna Lotti Suffredini, Neelam Thukral, Jacopo Secci, Bennie H. Jeng, and Amy D. Shapiro. "Safety & Efficacy of Human Plasma Derived Plasminogen Ophthalmic Drops for Treatment of Ligneous Conjunctivitis: Report of Phase 2/3 Clinical Trial." Blood 126, no. 23 (December 3, 2015): 2288. http://dx.doi.org/10.1182/blood.v126.23.2288.2288.

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Abstract INTRODUCTION Plasminogen deficiency is a rare autosomal recessive disorder with variable penetrance with multisystem manifestations that may result in significant morbidity. Most commonly, type-1 (quantitative defect) is associated with characteristic fibrin rich pseudomembranes in mucosal surfaces, the most common site being the eye, called Ligneous Conjunctivitis (LC). Two-thirds of patients have bilateral eye lesions and 1/3 have corneal involvement. Initially, patients present with non-specific conjunctivitis with epiphora, followed by white-red woody lesions replacing normal membranes and resulting in visual impairment/loss. LC may be triggered/exacerbated by infection, inflammation, or trauma. Although some non-specific modalities have been reported to result in lesion improvement/resolution, only FFP and topical/systemic plasminogen are consistently effective. Surgical intervention without effective replacement therapy results in lesion regrowth. Currently, local or systemic plasminogen replacement therapy is unavailable. Therefore, development of locally administered plasminogen concentrate represents an important advance in therapeutic options for LC. OBJECTIVES A phase 2/3 study is being conducted to evaluate the safety and efficacy of Kedrion plasma derived (pd) plasminogen ophthalmologic drops for treatment of LC associated with type I plasminogen deficiency. METHODS An ongoing open-label, multicenter, historically-controlled trial divided into 3 segments began on 5/22/2012. Three sites (1 US, 2 Italy) enrolled subjects. Segment 1 is 4 week treatment to evaluate clinical safety/efficacy followed by surgical excision of residual pseudomembranous, if required; segment 2 includes 8 weeks post-operative treatment/monitoring; segment 3 is a continuation phase with long-term safety monitoring until product licensure. Treatment regimens range from 2 drops/eye 4-12 times daily based on symptoms, study group and segment. The investigational medical product is a sterile human pd plasminogen, solvent/detergent treatment, nanofiltrated virally inactivated. During processing, the plasma pool is supplemented with bovine aprotinin to prevent plasminogen conversion to plasmin. RESULTS Segments 1 and 2 are complete; segment 3 is ongoing. The interim analysis is according to study protocol. Eleven subjects were enrolled (plasminogen activity range 5.1-34.26%; median 17.08%); age ranged between 1-44 yrs (median 4 yrs) including 4 males and 7 females; 7 had unilateral and 4 had bilateral lesions at enrolment. Three subjects did not require surgical intervention, and 8 required one excision of residual lesions after 4 weeks of therapy. In all compliant subjects, full regression and/or absence of recurrence post-excision were reported. One adult male subject, with bilateral involvement and severe visual impairment, was withdrawn due to noncompliance in study segment 2 after excision with subsequent lesion recurrence. Two subjects (1 during segment 1-2 and 1 during segment 3) developed plasma anti-plasminogen antibodies which are being further characterized as to specificity; these two subjects continue to respond to local therapy and remain symptom-free (Table 1). No viral seroconversion was detected. CONCLUSION LC in type 1 plasminogen deficiency can result in significant morbidity without an available effective local therapy. Kedrion human pd plasminogen ophthalmologic drops were found to be effective and well tolerated and represent an important advance in the treatment of this unusual manifestation of a rare disease, plasminogen deficiency. Table 1. Study Data Summary Subject # Age (Yrs) Sex Eye Lesions Surgery Required Therapeutic Response Plasminogen Ab Withdrawal (Reason) Left Right 1 2 M X No F Negative No 2 44 F X Yes P Negative No 3 32 M X X Yes R Negative Yes (poor compliance) 4 1 F X No F Negative No 5 4 M X X Yes P Positive No 6 1 F X No F Negative No 7 1 F X Yes P Negative No 8 3 M X X Yes P Negative No 9 4 F X Yes P Negative No 10 8 F X X Yes P Positive No 11 7 F X Yes P Negative No Total 9 6 8 procedures 2 1 15 symptomatic F: Full regression of lesions by end segment 1; no surgery required, no recurrence in segment 3 P: Partial regression by the end of segment 1 with surgery required for residual lesion(s). No recurrence post-operatively or in segment 3. R: Recurrence Disclosures Nakar: Kedrion: Research Funding. Caputo:Kedrion: Research Funding. Price:Kedrion: Research Funding; Alphaeon, Calhoun Vision Inc., Interactive Medical Publishing, Inc., ReVital Vision, TearLab,Valeant Pharmaceuticals/Bausch and Lomb: Equity Ownership; Cornea Research Foundation of America: Membership on an entity's Board of Directors or advisory committees; STAAR Surgical: Consultancy. Sartori:Kedrion: Research Funding. Suffredini:Kedrion SpA: Employment. Thukral:Kedrion: Research Funding. Secci:Kedrion: Research Funding. Jeng:Kedrion: Consultancy. Shapiro:Baxalta, Novo Nordisk, Biogen, ProMetic Life Sciences, and Kedrion Biopharma: Consultancy; Baxalta, Novo Nordisk, Biogen,: Membership on an entity's Board of Directors or advisory committees; Biogen: Speakers Bureau; Bayer Healthcare, Baxalta, Biogen, CSL Behring, Daiichi Sankyo, Kedrion Biopharma, Octapharma, OPKO, ProMetic Life Sciences, PTC Therapeutics, and Selexys: Research Funding.

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Bondar, S., O. Chabanova, T. Sharakhmatova, and A. Trubnikova. "ANALYSIS OF A NEW DIAFILTRATION METHOD OF CLEANING BUTTERMILK FROM LACTOSE WITH MINERAL COMPOSITION PRESERVED." Food Science and Technology 12, no. 1 (April 10, 2018). http://dx.doi.org/10.15673/fst.v12i1.839.

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Removing lactose from buttermilk and other dairy products is a topical problem, as there is a significant increase in morbidity rates due to lactose intolerance. In many cases, milk and dairy products containing lactose can not be completely excluded from the diet. These products have a number of valuable components. There are several ways to remove lactose from milk or other dairy products. They are based on separation methods of processing and on the use of enzymes. Among the separation methods, membrane treatment, including diafiltration, is of particular importance. A technique of engineering calculation of cleaning an ultrafiltration buttermilk concentrate is suggested. As a solvent that reduces the concentration of lactose, a nanofiltrate permeate of buttermilk ultrafiltration is used. This method allows preserving the chemical composition of the concentrate with lactose effectively removed. Basing on the experimental data of membrane productivity and their selectivity for lactose, the main characteristics of diafiltration are calculated for various practical applications. For practical purposes, it is advisable to use a buttermilk permeate nanofiltrate using highly selective lactose membranes. Selectivity for salts should be minimal. When comparing the different diafiltration variants, the most suitable is a periodic method, with continuous dilution, and a continuous method with a crossflow and reverse flow of the nanofiltrate. The smallest аmount of a nanofiltrate is observed in the case of a continuous countercurrent. The time for diafiltration treatment depends on the membrane’s specific parameters, process operating parameters, and the selected lactose purification variant. The most cost-effective is the continuous variant with a countercurrent nanofiltrate. However, it can not be recommended because of the considerable duration of the process. The suggested technique for calculating diafiltration allows quick evaluation of possible options of purifying the product from lactose, and concludes which one is optimal.

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DOMAŃSKA, Magdalena, Piotr DRAGAŃSKI, Paweł WIERCIK, Janusz ŁOMOTOWSKI, and Tomasz KONIECZNY. "POWSTAWANIE STRUWITU PODCZAS NANOFILTRACJI ODCIEKÓW Z FERMENTACJI METANOWEJ." Journal of Civil Engineering, Environment and Architecture, 2016. http://dx.doi.org/10.7862/rb.2016.151.

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Chen, Pei‐Chen, Yi‐Chen Lee, Hsing‐Yu Jao, Chi‐Ping Wang, Anthony Jacobs, Kevin Hu, Jordan Chen, Chien‐Shen Lo, and Huei‐Jane Lee. "Supplementation of nanofiltrated deep ocean water ameliorate the progression of osteoporosis in ovariectomized rat via regulating osteoblast differentiation." Journal of Food Biochemistry 44, no. 7 (June 2020). http://dx.doi.org/10.1111/jfbc.13236.

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Journal articles on the topic 'Nanofiltrace'

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