Relevant bibliographies by topics / Nanofluidic chips

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Nanofluidic chips'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Nanofluidic chips"

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Peng, Ran, and Dongqing Li. "Fabrication of polydimethylsiloxane (PDMS) nanofluidic chips with controllable channel size and spacing." Lab on a Chip 16, no. 19 (2016): 3767–76. http://dx.doi.org/10.1039/c6lc00867d.

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Shimizu, Hisashi, Shigenori Takeda, Kazuma Mawatari, and Takehiko Kitamori. "Ultrasensitive detection of nonlabelled bovine serum albumin using photothermal optical phase shift detection with UV excitation." Analyst 145, no. 7 (2020): 2580–85. http://dx.doi.org/10.1039/d0an00037j.

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Pezzuoli, Denise, Elena Angeli, Diego Repetto, Giuseppe Firpo, Patrizia Guida, Roberto Lo Savio, Luca Repetto, and Ugo Valbusa. "Nanofluidic Chips for DNA and Nanoparticles Detection and Manipulation." Biophysical Journal 116, no. 3 (February 2019): 293a. http://dx.doi.org/10.1016/j.bpj.2018.11.1583.

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Liu, Junshan, Liang Wang, Wei Ouyang, Wei Wang, Jun Qin, Zheng Xu, Shenbo Xu, et al. "Fabrication of PMMA nanofluidic electrochemical chips with integrated microelectrodes." Biosensors and Bioelectronics 72 (October 2015): 288–93. http://dx.doi.org/10.1016/j.bios.2015.05.031.

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Zhao, Wenda, Baojun Wang, and Wei Wang. "Biochemical sensing by nanofluidic crystal in a confined space." Lab on a Chip 16, no. 11 (2016): 2050–58. http://dx.doi.org/10.1039/c6lc00416d.

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This paper introduces a novel nanofluidic crystal scheme by packing nanoparticles inside a well-designed confined space to improve the device-to-device readout consistency. The readout from different chips (n = 16) varied within 8.4% under the same conditions, which guaranteed a self-calibration-free biochemical sensing.
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Chen, Xueye, and Lei Zhang. "Review in manufacturing methods of nanochannels of bio-nanofluidic chips." Sensors and Actuators B: Chemical 254 (January 2018): 648–59. http://dx.doi.org/10.1016/j.snb.2017.07.139.

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Chen, H. Matthew, Lin Pang, Michael S. Gordon, and Yeshaiahu Fainman. "Nanofluidic Chips: Real-Time Template-Assisted Manipulation of Nanoparticles in a Multilayer Nanofluidic Chip (Small 19/2011)." Small 7, no. 19 (September 27, 2011): 2678. http://dx.doi.org/10.1002/smll.201190070.

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Xu, Zheng, Jun-yao Wang, De-jia Wang, Chong Liu, Yun-liang Liu, Jun-shan Liu, and Li-ding Wang. "Flexible microassembly methods for micro/nanofluidic chips with an inverted microscope." Microelectronic Engineering 97 (September 2012): 1–7. http://dx.doi.org/10.1016/j.mee.2012.02.040.

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Utko, Pawel, Fredrik Persson, Anders Kristensen, and Niels B. Larsen. "Injection molded nanofluidic chips: Fabrication method and functional tests using single-molecule DNA experiments." Lab Chip 11, no. 2 (2011): 303–8. http://dx.doi.org/10.1039/c0lc00260g.

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Sun, Lei, Lingpeng Liu, Liping Qi, Ran Guo, Kehong Li, Zhifu Yin, Dongjiang Wu, Jiangang Zhou, and Helin Zou. "Fabrication of SU-8 photoresist micro–nanofluidic chips by thermal imprinting and thermal bonding." Microsystem Technologies 26, no. 3 (July 30, 2019): 861–66. http://dx.doi.org/10.1007/s00542-019-04565-2.

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Dissertations / Theses on the topic "Nanofluidic chips"

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Zaouter, Tony. "Etude des écoulements à l'interface joint-rugosité pour des applications de haute étanchéité." Thesis, Toulouse, INPT, 2018. http://www.theses.fr/2018INPT0116/document.

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Certaines applications industrielles nécessitent des niveaux d’étanchéité exceptionnels pour permettre la réalisation d’un vide poussé ou pour répondre à des enjeux de sécurité radiologique par exemple. Ces niveaux de haute étanchéité statique sur des assemblages démontables sont obtenus à l’aide de joints entièrement métalliques. La fuite résultante de l’assemblage n’est due qu’à la persistance d’un champ des ouvertures à l’interface entre le joint d’étanchéité et la bride d’assemblage, conséquence d’un contact imparfait entre les deux surfaces rugueuses. Le champ des ouvertures à l’interface de contact est assimilable à une fracture rugueuse hétérogène, de nature multi-échelle, et peut en principe être obtenu par un calcul de déformations mécaniques préalable. Dans ce travail, on s’intéressera plus particulièrement à l’écoulement gazeux raréfié dans le régime glissant au sein de cette fracture. Pour les régimes modérément raréfiés,l’écoulement est modélisé par l’équation de Reynolds faiblement compressible avec correction de glissement de premier ordre aux parois que l’on développe. On effectue ensuite un changement d’échelle par la méthode de la prise de moyenne volumique, permettant d’établir un modèle macroscopique d’écoulement à l’échelle d’un élément représentatif, où le débit massique est relié au gradient de pression via le tenseur de transmissivité. Celui-ci, caractéristique de l’élément représentatif de fracture, est calculé par résolution d’un problème de fermeture et est dépendant de la microstructure ainsi que du libre parcours moyen représentatif sur l’élément. Pour remonter à l’écoulement dans l’ensemble de la fracture, hétérogène à cette échelle, celle-ci est subdiviséeen pavés sur chacun desquels est calculé un tenseur de transmissivité local par la méthode sus-citée. Ensuite, l’écoulement dans ce champ de tenseurs est résolu par une méthode des éléments finis de frontière, donnant la transmissivité apparente glissante du joint dans son ensemble. Cette approche à deux échelles, vue comme outil d’aide à la conception, permet une réduction de la complexité de calcul par rapport à une simulation directe, rendant possible une analyse plus efficace du comportement d’un système d’étanchéité. Pour valider l’utilisation du modèle de glissement d’un point de vue macroscopique et s’affranchir des incertitudes sur le calcul de déformation mécanique, des puces nanofluidiques de type réseau hétérogène de canaux droits sont fabriquées par photolithographie par niveaux de gris. Des essais expérimentaux de mesure de fuite sont réalisés sur ces géométries modèles, représentant des joints idéalisés. Ces essais sont effectués en appliquant une forte différence de pression d’hélium par utilisation d’un spectromètre de masse mesurant la fuite, produisant une condition de vide en sortie de puce.Selon les puces, les régimes de raréfaction atteints vont alors du régime glissant au régime moléculaire. Le débit de fuite mesuré est alors supérieur à celui prédit par le modèle de premier ordre, l’écart restant inférieur à un ordre de grandeur quel que soit le régime
Some industrial applications require exceptional sealing levels to maintain ultra-high vacuumconditions or for radiological safety concerns for example. Such high performance static sealingconditions on mechanical assemblies are reached using entirely metallic gaskets. The resultingleak-rate is only due to the persistence of an aperture field at the seal-flange interface,consequence of a non-ideal contact between the two rough surfaces. This aperture field can beviewed as a rough and heterogeneous fracture, of multi-scale nature, and can be obtained by aprior contact mechanics computation. In this work, we are interested on the rarefied flow of a gasin this fracture, drawing our attention to the slip regime. For such moderately rarefied regime, theflow is described by the slightly compressible Reynolds equation with a first-order slip-flowcorrection at the walls, which we develop. Using the method of volume averaging, an upscalingprocedure is performed to derive the macroscopic flow model at the scale of a representativeelement, and where the mass flow rate is related to the pressure gradient by the transmissivitytensor. This latter is characteristic of the representative fracture element and is obtained by solvingan auxiliary closure problem which depends on the micro-structure as well as the representativemean free path on the element. To compute the flow in the whole fracture, heterogeneous at thisscale, it is subdivided in tiles on which a transmissivity tensor is locally computed by theaforementioned method. Then, the flow problem in this tensor field is solved using a boundaryelement method, leading to the apparent slip-corrected transmissivity of the entire aperture field.This two-scale approach is a conception tool which reduces the overall complexity with respect toa direct numerical simulation, allowing a more efficient analysis of the behavior of a sealingassembly. To validate the use of slip models at the macroscopic level and to eliminate theuncertainties of the contact mechanics computation, nanofluidic chips composed ofheterogeneous network of straight channels are fabricated using a grayscale photolithographytechnique. Experimental measurements of the leak-rate are performed on these idealizedgeometries that mimic a seal assembly. They are realized by applying a strong helium pressuredifference on the chip using a mass spectrometer to measure the leak, which produces a nearvacuum condition at the outlet. Depending of the chip, the rarefaction regime ranges from slip tofree-molecular. The measured leak-rate is greater than predicted by the first order model, thoughbeing of the same order of magnitude whatever the regime
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Hamblin, Mark Noble. "Thin Film Microfluidic and Nanofluidic Devices." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2281.

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Lab-on-a-chip devices, also known as micro total analysis systems (μTAS), are implementations of chemical analysis systems on microchips. These systems can be fabricated using standard thin film processing techniques. Microfluidic and nanofluidic channels are fabricated in this work through sacrificial etching. Microchannels are fabricated utilizing cores made from AZ3330 and SU8 photoresist. Multi-channel electroosmotic (EO) pumps are evaluated and the accompanying channel zeta potentials are calculated. Capillary flow is studied as an effective filling mechanism for nanochannels. Experimental departure from the Washburn model is considered, where capillary flow rates lie within 10% to 70% of theoretical values. Nanochannels are fabricated utilizing cores made from aluminum, germanium, and chromium. Nanochannels are made with 5 μm thick top layers of oxide to prevent dynamic channel deformation. Nanochannel separation schemes are considered, including Ogston sieving, entropic trapping, reptation, electrostatic sieving, and immutable trapping. Immutable trapping is studied through dual-segment nanochannels that capture analytes that are too large to pass from one channel into a second, smaller channel. Polymer nanoparticles, Herpes simplex virus type 1 capsids, and hepatitis B virus capsids are trapped and detected. The signal-to-noise ratio of the fluorescently-detected signal is shown to be greater than 3 for all analyte concentrations considered.
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Kumar, Suresh. "Design, Fabrication, and Optimization of Miniaturized Devices for Bioanalytical Applications." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5979.

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My dissertation work integrates the techniques of microfabrication, micro/nanofluidics, and bioanalytical chemistry to develop miniaturized devices for healthcare applications. Semiconductor processing techniques including photolithography, physical and chemical vapor deposition, and wet etching are used to build these devices in silicon and polymeric materials. On-chip micro-/nanochannels, pumps, and valves are used to manipulate the flow of fluid in these devices. Analytical techniques such as size-based filtration, solid-phase extraction (SPE), sample enrichment, on-chip labeling, microchip electrophoresis (µCE), and laser induced fluorescence (LIF) are utilized to analyze biomolecules. Such miniaturized devices offer the advantages of rapid analysis, low cost, and lab-on-a-chip scale integration that can potentially be used for point-of-care applications.The first project involves construction of sieving devices on a silicon substrate, which can separate sub-100-nm biostructures based on their size. Devices consist of an array of 200 parallel nanochannels with a height step in each channel, an injection reservoir, and a waste reservoir. Height steps are used to sieve the protein mixture based on size as the protein solution flows through channels via capillary action. Proteins smaller than the height step reach the end of the channels while larger proteins stop at the height step, resulting in separation. A process is optimized to fabricate 10-100 nm tall channels with improved reliability and shorter fabrication time. Furthermore, a protocol is developed to reduce the electrostatic interaction between proteins and channel walls, which allows the study of size-selective trapping of five proteins in this system. The effects of protein size and concentration on protein trapping behavior are evaluated. A model is also developed to predict the trapping behavior of different size proteins in these devices. Additionally, the influence of buffer ionic strength, which can change the effective cross-sectional area of nanochannels and trapping of proteins at height steps, is explored in nanochannels. The ionic strength inversely correlates with electric double layer thickness. Overall, this work lays a foundation for developing nanofluidic-based sieving systems with potential applications in lipoprotein fractionation, protein aggregate studies in biopharmaceuticals, and protein preconcentration. The second project focuses on designing and developing a microfluidic-based platform for preterm birth (PTB) diagnosis. PTB is a pregnancy complication that involves delivery before 37 weeks of gestation, and causes many newborn deaths and illnesses worldwide. Several serum PTB biomarkers have recently been identified, including three peptides and six proteins. To provide rapid analysis of these PTB biomarkers, an integrated SPE and µCE device is assembled that provides sample enrichment, on-chip labeling, and separation. The integrated device is a multi-layer structure consisting of polydimethylsiloxane valves with a peristaltic pump, and a porous polymer monolith in a thermoplastic layer. The valves and pump are fabricated using soft lithography to enable pressure-based sample actuation, as an alternative to electrokinetic operation. Porous monolithic columns are synthesized in the SPE unit using UV photopolymerization of a mixture consisting of monomer, cross-linker, photoinitiator, and various porogens. The hydrophobic surface and porous structure of the monolith allow both protein retention and easy flow. I have optimized the conditions for ferritin retention, on-chip labelling, elution, and µCE in a pressure-actuated device. Overall functionality of the integrated device in terms of pressure-controlled flow, protein retention/elution, and on-chip labelling and separation is demonstrated using a PTB biomarker (ferritin). Moreover, I have developed a µCE protocol to separate four PTB biomarkers, including three peptides and one protein. In the future, an immunoaffinity extraction unit will be integrated with SPE and µCE to enable rapid, on-chip analysis of PTB biomarkers. This integrated system can be used to analyze other disease biomarkers as well.
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Ngom, Sokhna Mery. "Dispositifs nanofluidiques à électro-préconcentration sélective." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS459.

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Détecter des biomolécules à l’état de traces reste l’un des enjeux actuels des biopuces. Les dispositifs nanofluidiques apparaissent aujourd’hui comme une voie prometteuse pour simultanément concentrer et détecter des biomolécules. Cette électro-préconcentration est possible grâce au caractère de perméabilité sélective de la nanofente (ou du nanocanal), qui se comporte sous champ électrique comme un «super-filtre» moléculaire à perméabilité sélective. Ce nanofiltre permet de piéger les analytes en amont ou en aval de la fente, dans l’un ou l’autre des réservoirs (anodique ou cathodique). Au cours de ce doctorat, j’ai développé et étudié des dispositifs nanofluidiques sur la base de deux géométries différentes : des nanofentes horizontales uniques et des réseaux de nanocanaux verticaux, dans une géométrie de code-barres. Pour les nanofentes horizontales, j’ai étudié l’évolution de la conductance en fonction de la force ionique et de la géométrie de la nanofente. Sur la base d’un protocole d’électro-préconcentration assistée en pression, j’ai établi des diagrammes « champ électrique/pression » qui permettent de prédire l’obtention d’un point focal stable où les analytes vont se concentrer. J’ai étudié le rôle de la longueur de la nanofente sur l’observation de ce point focal pour deux molécules modèles, la fluorescéine et l’ovalbumine. Pour les dispositifs à code-barres, j’ai mis au point un procédé de nanostructuration par lithographie électronique couplée à de la gravure profonde et un protocole de collage verre-verre. Les profils d’électropreconcentration obtenus pour différentes nanofentes au sein des codes-barres dynamiques permettent de discuter du rôle de la géométrie sur l’observation du point focal
Detecting trace biomolecules remains one of the current challenges for biochips. Nanofluidic devices appear today as a promising way to simultaneously concentrate and detect biomolecules. This electropreconcentration is possible thanks to the selective permeability of the fluidic nanoslit, which behaves under electric field as a molecular selective "super-filter". This nanofilter makes it possible to trap the analytes upstream or downstream of the slot, in one or the other of the reservoirs (anodic or cathodic). During this Ph.D., I developed and studied nanofluidic devices based on two different geometries: single horizontal nanoslits and vertical nanochannel arrays, in a barcode geometry. For horizontal nanoslits, I studied the evolution of the conductance as a function of the ionic strength and the nanoslit geometry. Based on a pressure-assisted electro-preconcentration protocol, I have established "electric field/ pressure" diagrams allowing predicting stabilization of a focal point where the analytes will concentrate. I have studied the role of the nanoslit length for two model molecules, fluorescein and ovalbumin. For barcode devices, I developed both a nanostructuration process by electron beam nanolithography coupled with deep etching and a glass-glass bonding protocol. The electroconcentration profils obtained for different nanofentes is discussed based on different dynamic barcodes
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Yuan, Xichen. "Charges à l’interface liquide/solide : caractérisation par courants d’écoulement et application à la préconcentration de molécules biologiques dans un système micro/nanofluidique." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1214/document.

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Les charges à l'interface liquide/solide sont un élément originel majeur des phénomènes électrocinétiques observés en micro/nanofluidique. Elles sont donc la colonne vertébrale de mon manuscrit de thèse, qui se décompose en trois parties : Dans la première partie, un rappel des concepts de base sur les interfaces liquides/solides est proposé au lecteur. Il est suivi d'une description des différentes méthodes expérimentales permettant de mesurer le potentiel zeta de couples solide/électrolyte, puis d'une présentation des travaux de la littérature exploitant les charges aux interfaces pour la préconcentration de molécules biologiques dans des systèmes Micro-Nano-Micro (MNM) fluidiques. Ensuite, une deuxième partie est consacrée à la mesure du potentiel zeta par la méthode des courants d'écoulement. Nous y présentons l'amélioration du banc expérimental issu des travaux antérieurs à ma thèse, ainsi que le développement de nouveaux protocoles de préparation des surfaces permettant de rationaliser et de stabiliser les mesures. Une application à un détecteur original de molécules biologiques clos cette deuxième partie. Enfin, la troisième et dernière partie s'intéresse à la préconcentration de molécules biologiques. Une méthode originale de fabrication des dispositifs MNM et les résultats de préconcentration obtenus, très encourageants, sont décrits. Des premiers modèles numériques et phénoménologiques sont proposés, qui mettent en avant l'originalité de notre travail
The charges at liquid/solid interfaces are a key element for both understanding and exploiting the electrokinetic phenomena in micro/nanofluidics. The manuscript of my Ph.D thesis is dedicated to these phenomena, which is divided into three main parts: Above all, a simple overview of charges at the liquid/solid interface is proposed. Then, several common methods for measuring the zeta potential at the liquid/solid interface are described. Next, various effective methods to preconcentrate the biological molecules is presented with the help of the surface charges. Secondly, the streaming current, which is a standard method to measure the zeta potential in our laboratory, is detailed. It contains the upgrade of the experimental setup from the previous version and the development of new protocols, which improve dramatically the stabilization and the reproducibility of the measurements. In addition, an original biological sensor is briefly presented based on these advancements. Lastly, in the final part, we describe a method which is primitively utilised in the fabrication of Micro-Nano-Micro fluidic system. Based on this system, some favorable preconcentration results is obtained. Moreover, numerical simulations are presented to prove the originality of our work
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Pardon, Gaspard. "From Macro to Nano : Electrokinetic Transport and Surface Control." Doctoral thesis, KTH, Mikro- och nanosystemteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-144994.

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Today, the growing and aging population, and the rise of new global threats on human health puts an increasing demand on the healthcare system and calls for preventive actions. To make existing medical treatments more efficient and widely accessible and to prevent the emergence of new threats such as drug-resistant bacteria, improved diagnostic technologies are needed. Potential solutions to address these medical challenges could come from the development of novel lab-on-chip (LoC) for point-of-care (PoC) diagnostics. At the same time, the increasing demand for sustainable energy calls for the development of novel approaches for energy conversion and storage systems (ECS), to which micro- and nanotechnologies could also contribute. This thesis has for objective to contribute to these developments and presents the results of interdisciplinary research at the crossing of three disciplines of physics and engineering: electrokinetic transport in fluids, manufacturing of micro- and nanofluidic systems, and surface control and modification. By combining knowledge from each of these disciplines, novel solutions and functionalities were developed at the macro-, micro- and nanoscale, towards applications in PoC diagnostics and ECS systems. At the macroscale, electrokinetic transport was applied to the development of a novel PoC sampler for the efficient capture of exhaled breath aerosol onto a microfluidic platform. At the microscale, several methods for polymer micromanufacturing and surface modification were developed. Using direct photolithography in off-stoichiometry thiol-ene (OSTE) polymers, a novel manufacturing method for mold-free rapid prototyping of microfluidic devices was developed. An investigation of the photolithography of OSTE polymers revealed that a novel photopatterning mechanism arises from the off-stoichiometric polymer formulation. Using photografting on OSTE surfaces, a novel surface modification method was developed for the photopatterning of the surface energy. Finally, a novel method was developed for single-step microstructuring and micropatterning of surface energy, using a molecular self-alignment process resulting in spontaneous mimicking, in the replica, of the surface energy of the mold. At the nanoscale, several solutions for the study of electrokinetic transport toward selective biofiltration and energy conversion were developed. A novel, comprehensive model was developed for electrostatic gating of the electrokinetic transport in nanofluidics. A novel method for the manufacturing of electrostatically-gated nanofluidic membranes was developed, using atomic layer deposition (ALD) in deep anodic alumina oxide (AAO) nanopores. Finally, a preliminary investigation of the nanopatterning of OSTE polymers was performed for the manufacturing of polymer nanofluidic devices.

QC 20140509


Rappid
NanoGate
Norosensor
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Iazzolino, Antonio. "Engineering three-dimensional extended arrays of densely packed nano particles for optical metamaterials using microfluidIque evaporation." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2013. http://tel.archives-ouvertes.fr/tel-01059235.

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1-Microevaporation - Microfluidics is the branch of fluid mechanics dedicated to the study of flows in the channel withdimensions between 1 micron and 100 micron. The object of this chapter is to illustrate the basicprinciples and possible applications of microfluidic chip, called microevaporator. In the first part ofthe chapter, we present a detailed description of the physics of microevaporators using analyticalarguments, and describe some applications. In the second part of the chapter, we present theexperimental protocol of engineering of micro evaporator and different type of microfluidics device.2- On-chip microspectroscopy - The object of this chapter is to illustrate a method to measure absorption spectra during theprocess of growth of our materials in our microfluidic tools. The aim is to make an opticalcharacterization of our micro materials and to carry-out a spatio-temporal study of kineticproperties of our dispersion under study. This instrumental chapter presents the theoretical basis !of the method we used.3-Role of colloidal stability in the growth of micromaterials - We used combined microspectroscopy and videomicroscopy to follow the nucleation and growth ofmaterials made of core-shell Ag@SiO2 NPs in micro evaporators.!We evidence that the growth is actually not always possible, and instead precipitation may occurduring the concentration process. This event is governed by the concentration of dispersion in thereservoir and we assume that its origin come from ionic species that are concentrated all togetherwith the NPs and may alter the colloidal stability en route towards high concentration. 4-Microfluidic-induced growth and shape-up of three-dimensional extended arrays of denselypacked nano particles - In this chapter I present in details microfluidic evaporation experiments to engineer various denselypacked 3D arrays of NPs.5-Bulk metamaterials assembled by microfluidic evaporation - In this chapter I introduced the technique we used (microspot ellipsometry) in close collaborationswith V.Kravets and A.Grigorenko(University of Manchester) and with A.Aradian, P.Barois, A.Baron,K.Ehrhardt(CRPP, Pessac) to characterized the solids made of densely packed NPs. I describe theconstraints that emerge from the coupling between the small size of our materials and the opticalrequirements, the analysis and interpretation of the ellipsometry experiments show that for thematerial with high volume fraction of metal exists the strong electrical coupling between the NPsand the materials display an extremely high refraction index in the near infra-red regime.
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Li, Chang-Yu, and 李昶郁. "Design and fabrication of protein concentration and separation in nanofluidic chips." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/22967175434236604891.

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碩士
國立中正大學
機械工程學系暨研究所
103
Developing the biochips for diagnosis of human sample is the future trend. It is an essential to pre-concentrate the sample and increase concentration before detecting in order to enhance the accuracy in follow-up analysis. The purpose of this microchip is employing the electric breakdown voltage and creating nanofractures which could concentrate and separate proteins in the sample. The pattern of the chip was fabricated via standard lithograph with a low-cost replica of polydimethylsiloxane (PDMS). Then, the nanofractures were created via the phenomenon of electric breakdown in the PDMS replica bonded with the glass substrate. The experiments for concentrating and separating the proteins were performed in this proposed chip. A commercial available fluorescein isothiocynate labeled bovine serum albumin (FITC-BSA) was used in this study. To validate the feasibility of this study, the numerical simulations for the separation channels with 100 μm and 300 μm in width were performed. The results showed that the efficiency for the 100 μm and 300 μm separation channel are 39 % and 63 %, respectively. This indicates a significant improvement on the efficiency of separation in the separation channel with 300 μm in width. The advantages of the chip in this study is not only convenient, fast and low-cost, but also to increase the efficiency of separation, which has potential for further development on disease diagnosis.
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De, Leebeeck Angela. "Nanofluidic species transport and nanostructure based detection on-chip." Thesis, 2006. http://hdl.handle.net/1828/2142.

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Transport in nanostructures and on-chip detection using nanohole arrays are investigated using a combination of analytical, numerical and experimental techniques. The first half of the thesis describes a fundamental theoretical contribution to the study of nanofluidic species transport. The second half of the thesis describes an applied experimental application of nanostructure-based species detection in a microfluidic framework. A continuum based analytical solution and numerical model are developed to quantify ionic dispersion of charged and neutral species in nanochannels and identify fundamental dispersion mechanisms unique to nanoscale flows. Ionic dispersion for circular cross-section nanochannels is quantified as a function of a valance parameter. the relative electrical double layer thickness. and the form of the velocity profile. Two unique mechanisms governing ionic dispersion in both pressure- and electrokinetically driven flows are identified. The results of the analytical solution are supported and extended by the results of the numerical model. Collectively, these results indicate that dispersion of ionic species in nanoscale channels is markedly charge dependent and substantially deviates from that of neutral solutes in the same flow. A microfluidic device with a set of embedded nanohole array surface plasmon resonance sensors is developed and successfully demonstrated experimentally as a chemical/biological sensor. The device takes advantage of the unique optical properties. the surface-based sensitivity, the transmission mode operation. relatively small footprint, and repeatability characteristic of nanohole arrays. Proof-of-concept measurements are performed on-chip to detect changes in liquid refractive index at the array surface. proportional to change in near wall concentration or indicative of a surface binding event. Employing a cross-stream array of nanohole arrays. the device is applied to detect microfluidic concentration gradients as well as to detect surface binding in the assembly process of a cysteamine monolayer-biotin-streptavidin system.
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Chiou, Heng-Chia, and 邱珩嘉. "A Biosensing Method Based on Nano-Particles’ Brownian Motion Applied to Nanofluidic Preconcentration Chip." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/03657647745290000142.

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碩士
國立臺灣大學
應用力學研究所
102
In this thesis, we have developed a novel detection method based on capturing preconcentrated plug preconcentrated by preconcentration chip and Brownian motion detection. Applying voltage drop to the preconcentrator which use Nafion as ion-selective membrane can generate ion concentration polarization (ICP) effect. The electroosmosis of second kind which generate by applying the bias voltage, force bulk solution to aggregate the preconcentration plug near the depletion region. Using the Brownian motion which analyze the characteristic of antigen-antibody interactions as detection mechanism to detect the preconcentration plug captured by pneumatic valve. 　　The design and the validation methods and processes of nanofluidic preconcentration chips and pneumatic valve were proposed starting from validation of resistive models, test of ion-selective membrane and test of Brownian motion by micro-Particle Tracking Velocimetry (micro-PTV), to get the onset of detection mechanism. 　　In summary, the presented nanofluidic preconcentrator and pneumatic valve demonstrates biological sample can be preconcentrated in short time and the plug can be captured by valve. With the analysis of loop currents and Brownian motion detection, various low biological sample could be demonstrated in the future.
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Books on the topic "Nanofluidic chips"

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Multidisciplinary Microfluidic and Nanofluidic Lab-On-a-Chip: Principles and Applications. Elsevier, 2020.

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Book chapters on the topic "Nanofluidic chips"

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Chen, Gang, and Xiaohong Chen. "Transferring Samples to Chips, Techniques." In Encyclopedia of Microfluidics and Nanofluidics, 3335–44. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_1616.

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Chen, Gang, and Xiaohong Chen. "Transferring Samples to Chips, Techniques." In Encyclopedia of Microfluidics and Nanofluidics, 1–11. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-3-642-27758-0_1616-3.

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Xue, Peng, and Yuejun Kang. "Paper-Based Sensors and Microfluidic Chips." In Encyclopedia of Microfluidics and Nanofluidics, 2647–55. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_1712.

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Xue, Peng, and Yuejun Kang. "Paper-Based Sensors and Microfluidic Chips." In Encyclopedia of Microfluidics and Nanofluidics, 1–9. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-3-642-27758-0_1712-4.

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Yeo, Leslie, and James Friend. "On-Chip Electrospray." In Encyclopedia of Microfluidics and Nanofluidics, 2503–13. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_1146.

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Papautsky, Ian, and Andrea Pais. "On-Chip Waveguides." In Encyclopedia of Microfluidics and Nanofluidics, 2519–29. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_1153.

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Bakajin, Olgica. "Chromatographic Chip Devices." In Encyclopedia of Microfluidics and Nanofluidics, 436–41. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_224.

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Daub, Martina, and Roland Zengerle. "Bioprinting on Chip." In Encyclopedia of Microfluidics and Nanofluidics, 124–38. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_92.

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Yeo, Leslie, and James Friend. "On-Chip Electrospray." In Encyclopedia of Microfluidics and Nanofluidics, 1–12. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-3-642-27758-0_1146-2.

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Papautsky, Ian, and Andrea Pais. "On-Chip Waveguides." In Encyclopedia of Microfluidics and Nanofluidics, 1–13. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-3-642-27758-0_1153-2.

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Conference papers on the topic "Nanofluidic chips"

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Parikesit, Gea O., Vladimir G. Kutchoukov, Wim van Oel, Guus L. Lung, Andre Bossche, Ian T. Young, and Yuval Garini. "Optical detection of single molecules in nanofluidic chips." In Optical Science and Technology, the SPIE 49th Annual Meeting, edited by Elizabeth A. Dobisz and Louay A. Eldada. SPIE, 2004. http://dx.doi.org/10.1117/12.559386.

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Cheng, Ya, Yang Liao, and Koji Sugioka. "Femtosecond laser 3D nanofabrication in glass: enabling direct write of integrated micro/nanofluidic chips." In SPIE LASE, edited by Yoshiki Nakata, Xianfan Xu, Stephan Roth, and Beat Neuenschwander. SPIE, 2014. http://dx.doi.org/10.1117/12.2042742.

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Darvishi, Samira, and Thomas Cubaud. "Viscous Core-Annular Flows in Microfluidic Chambers." In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30164.

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The manipulation of highly viscous materials at the microscale is a key challenge for implementing lab on chips with the ability to manage a variety of complex and reactive fluids. We describe methods for producing and controlling high-viscosity fluid threads flowing in sheath of less viscous fluids, i.e., viscous core-annular flows, in microchannels. The self-lubrication property of multi-fluid flows having large viscosity contrasts offers a promising means for manipulating interfaces between “thick” and “thin” fluids and for reducing the hydraulic resistance in micro- and nanofluidic devices. In particular, we focus on the flow behavior of threads as they traverse diverging-converging slit microfluidic chambers. The alteration of convective time-scales using extensional microgeometries permits the manipulation of complex phenomena such as viscous buckling, wetting, and coalescence. We examine the interrelation between these phenomena that are useful for passively enhancing mixing between miscible fluids and for initiating continuous emulsification processes between immiscible fluids having widely disparate viscosities.
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Wei, Jianjun, Hongjun Song, Sameer Singhal, Matthew Kofke, Madu Mendis, and David Waldeck. "An In-Plane Nanofluidic Nanoplasmonics-Based Platform for Biodetection." In ASME 2012 Third International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/mnhmt2012-75206.

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This paper reports a new nanofluidic plasmonics-based sensing platform which can be readily integrated with microfluidics devices, and potentially enable an in-parallel transmission surface plasmon resonance (SPR), lab-on-chip sensing technology. The technology overcomes the current SPR size limitations through a combination of nanofluidics and nanoplasmonics in a rationally designed in-plane nanoslit array capable of concurrent plasmonic sensing and confined-flow for analyte delivery. This work is leveraged on our previous work of using nanoslit metal films for SPR sensing [1, 2], and the in-plane nanofluidic nanoplasmonic platform is different from recently reported nanohole-based nanofluidic plasmonics sensors [3, 4]. The work presented here includes an integrated device with nanofluidic nanoplasmonic arrays interfacing with microfluidic channels, and preliminary findings, from both theoretical and experimental fronts, of the device for bio-sensing.
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Roy, Sougata, and Amitava Ghosh. "High Speed Turning of AISI 4140 Steel Using Nanofluid Through Twin Jet SQL System." In ASME 2013 International Manufacturing Science and Engineering Conference collocated with the 41st North American Manufacturing Research Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/msec2013-1067.

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Application of small quantity lubrication (SQL) technology in high speed machining is being recognized as a sustainable approach for achieving suitable cooling/lubrication in machining zone. Present investigation focused on effectiveness of SQL with nanofluids in high speed turning of AISI 4140 steel with a TiN-top coated multilayered carbide insert and explored the advantages of using a twin-jet SQL system instead of a single jet one. SQL system was developed in-house with external-mix nozzles. The experiment was conducted varying the cutting velocity at two different feed rates (0.05mm/rev and 0.10mm/rev) with conventional coolant and nanofluids. Immediate improvement in machinability and the quality of turned surface was observed with twin-jet nanofluid SQL. A significant reduction of force and specific energy could be achieved by using 3vol% alumina and 1vol% multi walled carbon nano tube (MWCNT) nanofluid instead of soluble oil. The MWCNT nanofluid was found to be superior to alumina nanofluid in reduction of tensile residual stress. Such a reduction is typically an indirect indication of reduction of cutting zone temperature, which could be achieved due to enhanced level of lubricity at chip-tool interface and enhanced level of heat dissipation ability of the nanofluids. Improvement in retention of sharpness of tool cutting edges was also observed under nanofluid-SQL environment, which could have played important role in improvement of surface quality.
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Alfi, M., H. Nasrabadi, and D. Banerjee. "Confinement Effects on Phase Behavior of Hydrocarbon in Nanochannels." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52845.

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Several researchers have recently studied the phase behavior of petroleum fluids in shale systems. There is a general agreement that the confined PVT properties in shale are substantially different from the corresponding bulk properties. These differences have significant impact on the prediction of well performance and ultimate recovery in shale reservoirs. Experimental measurements of fluid properties in shale rocks are currently not available. This has led to significant amount of uncertainty in phase behavior calculations for shale reservoirs. In this study, experimental validation of numerical predictions for phase behavior of various hydrocarbons confined in nanochannels was performed using a nanofluidics platform. The nanofluidics platform was designed, fabricated and tested at different temperatures. Design of the nanochannel is described in this paper. In this study, a nanochannel device (similar to Duan and Majumdar 2010) was designed, fabricated, packaged and tested. The reservoirs in the nanofluidic chip were filled with various hydrocarbon liquids (e.g. n-decane). The temperature was varied at a constant pressure, during which epifluorescence imaging was performed to measure the bubble nucleation temperature, i.e., the temperature corresponding to the formation of the first bubble of gas (i.e., to determine bubble-point pressure and temperature relationship).
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Rahman, Mosfequr, Andrew Hudson, Gustavo Molina, and Valentin Soloiu. "Numerical Analysis of Laminar Natural Convection in Rectangular Enclosures of Different Aspect Ratios With and Without Aerosol Nanofluid." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65056.

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Natural convection heat transfer in rectangular enclosures is important in many real-world engineering applications. Included in these applications are the energy efficient design of buildings, operation and safety of nuclear reactors, solar collector design, passive energy storage, heat transfer across multi-pane windows, thermo-electric refrigeration and heating devices, and the design-for-mitigation of optical distortion in large-scale laser systems, environmental engineering and electronic packaging. A common industrial application of natural convection is free air cooling without the aid of fans and can happen on small scales such as computer chips to large scale process equipment. In addition to temperature gradient convection strength within the enclosure can vary due to the existence of nanoparticles with the base fluid. The field of nanofluid research has been expanding in recent years. Most of the research performed for the purpose of heat transfer using nanofluids has been conducted on liquid based nanofluids, leaving the aerosol-based nanofluid research lagging. There is also a deficit in the research previously performed to develop a computer model of heat transfer enhancement using nanofluid. The transport of solid particles and liquid droplets in a fluid has long been a subject of great interest. Understanding, measuring, and quantifying the deposition of aerosol on walls is important in various sectors of science and technology. Some examples are the deposition of drugs and harmful substances in the nasal and respiratory tracts in medical science and engineering; deposition of particles and droplets in gas and steam turbines in power plant engineering; the atmospheric dispersal of pollutants and the determination of indoor air quality in environmental science; the transport and sedimentation of various substances in rivers in civil engineering; fouling of process and heat transfer equipments in process industries; and the transport of chemical aerosols in chemical process engineering. In this research work the case of pure air was first solved for 6 different aspect ratios, then the nanofluid was introduced and the resulting heat transfer was observed. The aerosol nanofluid used was composed of air with copper nanoparticles suspended in an enclosure. This procedure was repeated for multiple aspect ratios. This research also develops a functional computer model for heat transfer enhancement using nanofluid.
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Pramuanjaroenkij, Anchasa, Amarin Tongkratoke, and Sadık Kakaç. "Numerical Study of Turbulence Nanofluid Flow to Distinguish Multiphase Flow Models for In-House Programming." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66606.

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Fluid flow with particles are found in many engineering applications such as flows inside lab-on-a-chips and heat exchangers. In heat exchangers, nanofluids or base fluids mixed with nanoparticles are applied to be used as the working fluid instead of the traditional base fluids which have low thermal-physical properties. The nanoparticle diameters are in the range from 1 to 100 nanometers are mixed with the traditional base fluids before they are applied inside the heat exchangers and the nanofluids have been proved continually that they enhance heat transfer rates of the heat exchangers. Turbulent and laminar nanofluid flows have shown different enhancements in different conditions. This work focused on comparing different turbulent nanofluid simulations which used the computational fluid dynamics, CFD, with different multiphase models. The Realizable k-ε turbulence model coupled with three multiphase models; Volume of Fluid (VOF) model, Mixture model and Eulerian model, were considered and compared. The heat exchanger geometry in the work was rectangular as in the electrical device application and the nanofluid was a mixture between Al2O3 and water. All simulated results, then, were compared with experimental results. The comparisons showed that numerical results did not deviate from each other but their delivered-time consumptions and complications were different. If one develops his own code, Eulerian model was the most complicated while Mixture model and Eulerian model consumed longer performing times. Although the Eulerian model delivered-time consumption was long but it provided the best results, so the Eulerian model should be chosen when time consumption and errors play important roles. From this ordinary study, the first significant step of in-house program developments has started. The time consumption still indicated that the high performance computers should be selected, and properties obtained from the experimental studies should be imported to the simulation to increase the result accuracy.
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Wu, Junqing, Gaurav Soni, Dazhi Wang, and Carl D. Meinhart. "AC Electrokinetic Pumps for Micro/NanoFluidics." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61836.

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We have developed micropumps for microfluidics that use AC electric fields to drive aqueous fluid motion through micro channels. These pumps operate at relatively low voltages (~5–10Vrms), and high frequencies (~100kHz). They have several distinct advantages over the DC electrokinetic pumps. The low voltages make the pumps well suited for a wide variety of biosensor and “Lab-on-a-Chip” applications (e.g. PCR chip for DNA amplification). The high frequencies minimize electrolysis, so that bubbles do not form on the electrode surfaces, and do not contaminate the working fluid. The pumps can also be used as active valves or precision micro-dispensers.
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Yeo, Woon-Hong, Dong Won Lee, Kyong-Hoon Lee, and Jae-Hyun Chung. "Shadow Edge Lithography and Application to Nanofluidics." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13307.

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Many upcoming applications, such as nanoelectronic circuitry, single-molecule based chips, nanofluidics, chemical sensors, and fuel cells, require large arrays of nanochannels and nanowires. To commercialize such nanostructured devices, a high resolution and high throughput patterning method is essential. For this purpose, we developed the shadow edge lithography (SEL) as a wafer-scale, high-throughput nanomanufacturing method [1]. In the proposed method, the shadow effect in the high-vacuum evaporation was theoretically analyzed to predict the geometric distribution of the nanoscale patterns [2]. In experiment, nanoscale patterns were created by the shadow of aluminum (Al) edges that were prepatterned using a conventional microfabrication method.
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