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Journal articles on the topic 'Nanoparticle formulations'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Ogba, Chukwuemeka Emmanuel, Akpabio Elijah Akwaowoh, Ifeoluwa Adetomiwa Taiwo, Precious Joshua Edem, and Sunday Olajide Awofisayo. "Optimizing levofloxacin delivery using nanoparticles: a strategy for improved bioavailability and targeted release." Journal of Drug Delivery and Therapeutics 15, no. 5 (2025): 42–49. https://doi.org/10.22270/jddt.v15i5.7119.

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Nanoparticle-based drug delivery systems have emerged as a powerful strategy to enhance drug bioavailability and ensure targeted therapeutic release. Levofloxacin (LFX), a widely used broad-spectrum fluoroquinolone antibiotic, is limited by poor aqueous solubility, low oral bioavailability, and systemic side effects. This study investigates the formulation, characterization, and evaluation of levofloxacin-loaded nanoparticles aimed at improving its pharmacological performance. Various nanoparticle carriers, including polymeric nanoparticles, lipid-based nanocarriers, and inorganic nanoparticle

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Johnstone, Sharon, Steven Ansell, Sherwin Xie, Lawrence Mayer, and Paul Tardi. "The Use of Radioactive Marker as a Tool to Evaluate the Drug Release in Plasma and Particle Biodistribution of Block Copolymer Nanoparticles." Journal of Drug Delivery 2011 (July 7, 2011): 1–9. http://dx.doi.org/10.1155/2011/349206.

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Diblock copolymer nanoparticles encapsulating a paclitaxel prodrug, Propac 7, have been used to demonstrate the usefulness of a nonmetabolizable radioactive marker, cholesteryl hexadecyl ether (CHE), to evaluate nanoparticle formulation variables. Since CHE did not exchange out of the nanoparticles, the rate of clearance of the CHE could be used as an indicator of nanoparticle stability in vivo. We simultaneously monitored prodrug circulation and carrier circulation in the plasma and the retention of CHE relative to the retention of prodrug in the plasma was used to distinguish prodrug release

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Faizan, Khan1 Surendra Dangi*2 Dr. Bhaskar Kumar Gupta3. "Review on Nanoparticle-Based Creams: Formulation, Characterization, and Applications in Therapeutics." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3049–54. https://doi.org/10.5281/zenodo.15280634.

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Nanoparticle-based creams have emerged as a promising advancement in the field of pharmaceutical and cosmetic formulations due to their ability to enhance drug delivery, improve skin penetration, and provide sustained release of active ingredients. This review explores the formulation strategies, characterization techniques, and therapeutic applications of nanoparticle creams. Various types of nanoparticles, including liposomes, solid lipid nanoparticles (SLNs), and polymeric nanoparticles, are discussed in terms of their advantages, challenges, and suitability for topical application. Additio

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S., Vivekanandan, Lindholm Berit, Raghunandan Reddy K, and Venkatesan P. "Formulation and Characterization of Chitosan Based Dexibuprofen Nanoparticles Using Ionotropic Gelation Method." International Journal of pharma and Bio Sciences 11, no. 6 (2021): 48–57. http://dx.doi.org/10.22376/ijpbs/lpr.2021.11.6.p48-57.

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Dexibuprofen is a pharmacologically active enantiomer of racemic ibuprofen (NSAID), which is used to treat pain and inflammation. Like common NSAIDs, Dexibuprofen is an active enantiomer of ibuprofen that suppresses the prostanoid synthesis in the inflammatory cells via inhibition of the COX-2 isoform of the arachidonic acid COX. The therapeutic use of Dexibuprofen is limited by the rapidity of the onset of its action and its short biological half-life. Hence, our aim was to develop Dexibuprofen nanoparticles formulation to overcome these disadvantages using optimized concentration of polymers

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Levit, Shani L., Narendar Reddy Gade, Thomas D. Roper, Hu Yang, and Christina Tang. "Self-Assembly of pH-Labile Polymer Nanoparticles for Paclitaxel Prodrug Delivery: Formulation, Characterization, and Evaluation." International Journal of Molecular Sciences 21, no. 23 (2020): 9292. http://dx.doi.org/10.3390/ijms21239292.

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The efficacy of paclitaxel (PTX) is limited due to its poor solubility, poor bioavailability, and acquired drug resistance mechanisms. Designing paclitaxel prodrugs can improve its anticancer activity and enable formulation of nanoparticles. Overall, the aim of this work is to improve the potency of paclitaxel with prodrug synthesis, nanoparticle formation, and synergistic formulation with lapatinib. Specifically, we improve potency of paclitaxel by conjugating it to α-tocopherol (vitamin E) to produce a hydrophobic prodrug (Pro); this increase in potency is indicated by the 8-fold decrease in

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Kumar, Niwash. "Preparation, Evaluation & Optimization of Nanoparticles Composed of Pyridostigmine." International Journal for Research in Applied Science and Engineering Technology 9, no. 11 (2021): 1422–38. http://dx.doi.org/10.22214/ijraset.2021.38902.

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Abstract: The purpose of this study was to prepare Pyridostigmine nanoparticles for control release of Pyridostigmine to improve the oral bioavailability, enhance the solubility and dissolution rate by decreasing particle size of drug. Infrared spectroscopic studies confirmed that there was no interaction between drug and polymers. The controlled release Pyridostigmine nanoparticles were prepared by Solvent evaporation by using Ethyl cellulose, Chitosan & HPMC K100 at different ratios. The production yield of the formulated controlled release nanoparticles (F1 to F16) in the range of 76.11

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Shukla, Prashant, Shweta Sharma, and Padma Rao. "Nanoparticulate drug delivery systems: A revolution in design and development of drugs." Journal of Drug Delivery and Therapeutics 11, no. 5-S (2021): 188–93. http://dx.doi.org/10.22270/jddt.v11i5-s.5023.

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The recent developments in nanoparticle-based drug formulations have been helping to address issues around treating challenging diseases. Nanoparticles come in different sizes but usually vary between 100nm to 500nm. For the past few years there has been research going on in the area of drug delivery using particulate delivery systems. Various drug molecules have been modified for both pharmacokinetic and pharmacodynamic properties using nanoparticles as physical approach. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic ben

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Snehal, Bhavsar* Bhagyashri Patil Komal Bhoi Shital Patil Harshada Jadhav Tulsi Ahuja. "Herbomineral Nano-Formulations of Alternative System of Medicine." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1239–46. https://doi.org/10.5281/zenodo.14876124.

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The herbs and herbal substances are of significant research interest because of their diverse medicinal applications. Several folk evidences have been reported in the formulations of the ancient worlds the pharmaceutical system, encouraging researchers to look for scientific support. Several herbal compounds have been discovered and tested for therapeutic efficacy against pathophysiological disorders. Recently, attempts have been undertaken to employ these herbal components to create nanoparticles for biomedical applications. Green synthesis is a method of producing nanoparticles from herbal/b

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Mahmoud, Doaa Elsayed, Seyedeh Hanieh Hosseini, Hassaan Anwer Rathore, Alaaldin M. Alkilany, Andreas Heise, and Abdelbary Elhissi. "Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases." Pharmaceutics 17, no. 7 (2025): 893. https://doi.org/10.3390/pharmaceutics17070893.

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This review explores recent advancements in inhaled nanoparticle formulations and inhalation devices, with a focus on various types of nanoparticles used for inhalation to treat inflammatory lung diseases and the types of devices used in their delivery. Medical nebulizers have been found to be the most appropriate type of inhalation devices for the pulmonary delivery of nanoparticles, since formulations can be prepared using straightforward techniques, with no need for liquefied propellants as in the case of pressurized metered dose inhalers (pMDIs), or complicated preparation procedures as in

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Matschegewski, Claudia, Anja Kowalski, Knut Müller, et al. "Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications." Current Directions in Biomedical Engineering 5, no. 1 (2019): 573–76. http://dx.doi.org/10.1515/cdbme-2019-0144.

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AbstractMagnetic nanoparticles are highly promising for the usage in various biomedical applications including magnetic particle imaging (MPI), cancer hyperthermia treatment or as drug carriers. The present study aims at assessing in vitro biocompatibility of two commercially available magnetic iron oxide nanoparticle formulations: dextran-based magnetic nanoparticle synomag-D and bionized nanoferrite BNF-starch. Biological performance of both nanoparticle formulations were studied in human endothelial cells by analyzing cell viability and nanoparticle internalization in order to judge their s

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Ako-Adounvo, Ann-Marie, and Pradeep K. Karla. "Preparation and In Vitro Testing of Brinzolamide-Loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles for Sustained Drug Delivery." Journal of Clinical & Translational Ophthalmology 2, no. 1 (2024): 1–14. http://dx.doi.org/10.3390/jcto2010001.

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Glaucoma therapy aims at lowering intra-ocular pressure (IOP). Brinzolamide, a carbonic anhydrase inhibitor, is utilized as a second-line medication for treating ocular hypertension and primary open-angle glaucoma (POAG). The drug lowers the IOP making it a therapeutic agent against glaucoma, and due to its poor water solubility, is commercially available as Azopt®, a 1% ophthalmic suspension. Adverse effects such as blurred vision, ocular irritation, discomfort, and bitter taste are associated with the use of the marketed brinzolamide formulation. This study aims to test the feasibility of fo

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Tripathi, Richa, and Vivek Chourasia. "Formulation And Characterization Of Silver Nanoparticles Incorporated Gel Of Ethanolic Extract Of Celastrus Orbiculatus For Effective Antimicrobial Effect." International Journal of Environmental Sciences 11, no. 7s (2025): 796–807. https://doi.org/10.64252/z29y0t64.

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The present study focuses on the green synthesis of silver nanoparticles (AgNPs) using the ethanolic extract of Celastrus orbiculatus and their incorporation into hydrogel formulations for enhanced topical antimicrobial activity. Various nanoparticle formulations (F1–F9) were evaluated for percentage yield, entrapment efficiency, and particle size, with formulation F2 identified as the optimized batch. Characterization using FTIR, UV–Vis spectroscopy, and SEM confirmed successful nanoparticle synthesis and morphology. The optimized AgNPs were incorporated into hydrogel formulations (G1–G6), wi

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Ali, Muhammad, Viviana Benfante, Domenico Di Raimondo, Giuseppe Salvaggio, Antonino Tuttolomondo, and Albert Comelli. "Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent." Pharmaceuticals 17, no. 1 (2024): 126. http://dx.doi.org/10.3390/ph17010126.

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Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, its anticancer efficacy is impeded by low water solubility, dose-limiting toxicity, low bioavailability, and rapid hepatic metabolism. To overcome these hurdles, various nanoparticles such as organic and inorganic nanoparticles, liposomes, polymeric nanoparticles, dendrimers, solid lipid nanoparticles, gold nanoparticles, zinc oxide nanoparticles, zeolitic imidazolate frameworks, carbon na

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Dubey, Anubhav. "Formulation and Evaluation of Antiviral Agent Loaded Polymeric Nanoparticles." International journal of therapeutic innovation 2, no. 3 (2024): 0163–69. http://dx.doi.org/10.55522/ijti.v2i3.0052.

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The present study focuses on the development of polymeric gelatin nano-particulates of acyclovir sodium with the goal of improving solubility and bioavailability through controlled release. Acyclovir sodium is an antiviral agent with a short half-life and oral bioavailability of 2.5–3.3 hours (15–30%), respectively, and is used to treat a variety of herpes infections. The purpose of this study was to prepare, evaluate, and in vitro release the characterization of acyclovir sodium-loaded polymeric nanoparticles. We fabricated the polymeric nanoparticles of Acyclovir sodium using varying concent

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Islam, Shahadatul, Dr Rafatul Haque Rishad, and Mysha Anjum Rupa. "Formulation Development of Gliclazide & Glipizide Nanoparticle: A Comparative Systematic Review." International Journal of Research and Scientific Innovation XII, no. XV (2025): 891–97. https://doi.org/10.51244/ijrsi.2025.121500079p.

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The use of nanoparticles (NPs) for the delivery of antidiabetic gliclazide and glipizide is elaborated in the systematic review of the literature. This systematic review presents a proper comparative examination of the development of nanoparticle formulations for gliclazide and glipizide, two sulphonyl urea medications used in the treatment of type 2 diabetes. Because of their potential to increase medication solubility, bioavailability, and grant sustained release, nanoparticle-based drug delivery systems have received a lot of interest. The review gives an overview of the pharmacological cha

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R., Redya Naik. "Human Paraoxonase-1: Functional Insights Within PLGA-Based Nanoparticles." International Journal of Pharmacy and Biological Sciences (IJPBS) 9, no. 2 (2019): 1519–23. https://doi.org/10.5281/zenodo.13621929.

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Abstract Human serum paraoxonase-1 (PON1) is a calcium dependent interfacial activated membrane protein associated with high density lipoproteins (HDL) play significant role in fundamental biological processes. This study determines the feasibility of formulating PON1 loaded solid lipid nanoparticles for developing a surrogate for the HDL associated PON1 in the form of PLGA (Poly Lactic glycolic acid) based solid lipid nano formulations. Studies were made on the preparation of h-PON1(human Paraoxonase-1) loaded solid lipids nano formulations with PLGA and all activities of PON-1 like lactonase

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Gupta, M., R. K. Marwaha, and H. Dureja. "Formulation and Characterization of Gefitinib-loaded Polymeric Nanoparticles Using Box-Behnken Design." Current Nanomedicine 9, no. 1 (2019): 46–60. http://dx.doi.org/10.2174/2468187308666180815145350.

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Background:Nanotechnology has considerably modified the treatment of cancer by overcoming the prevailing drawbacks in conventional chemotherapy like severe systemic side effects, undesirable bio-distribution and drug resistance.Objective:The objective behind the present study was to develop polymeric nanoparticles loaded with gefitinib by ionic gelation method and optimize the prepared nanoparticles using Box-Behnken Design at 3-factors and 3-levels. The main and interactive effects of three selected process variables i.e chitosan concentration, sodium tripolyphosphate (NaTPP) concentration an

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Gómez, Sara, Carlos Gamazo, Beatriz San Roman, Christine Vauthier, Marta Ferrer, and Juan M. Irache. "Development of a Novel Vaccine Delivery System Based on Gantrez Nanoparticles." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 3283–89. http://dx.doi.org/10.1166/jnn.2006.471.

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The adjuvant capacity of a novel vaccine vector "Gantrez-nanoparticles" (NP) towards coated or encapsulated ovalbumin (OVA) was investigated. OVA nanoparticles were prepared by a solvent displacement method previously described. The protein was incorporated during the manufacturing process (OVA-encapsulated nanoparticles) or after the preparation (OVA-coated nanoparticles). The mean size of the different nanoparticle formulations was lower than 300 nm, and the OVA content ranged approximately from 67 μg/mg nanoparticles (for OVA-coated nanoparticles) to 30 μg/mg nanoparticles (for OVA-encapsul

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Tang, Xu, Bin Zeng, Jian-Kun Gao, and Han-Qiang Liu. "Molecular Mechanism of Enhanced Anticancer Effect of Nanoparticle Formulated LY2835219 via p16-CDK4/6-pRb Pathway in Colorectal Carcinoma Cell Line." Journal of Nanomaterials 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/2095878.

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LY2835219 is a dual inhibitor to CDK4 and CDK6. This study was to prepare LY2835219-loaded chitosan nanoparticles (CNP/LY) and LY2835219-loaded hyaluronic acid-conjugated chitosan nanoparticles (HACNP/LY) and revealed their anticancer effect and influence on p16-CDK4/6-pRb pathway against colon cell line. The nanoparticle sizes of CNP/LY and HACNP/LY were approximately195±39.6 nm and217±31.1 nm, respectively. The zeta potentials of CNP/LY and HACNP/LY were37.3±1.5 mV and30.3±2.2 mV, respectively. And the preparation process showed considerable drug encapsulation efficiency and loading efficien

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Lima, Caroline S. A. de, Justine P. R. O. Varca, Kamila M. Nogueira, et al. "Semi-Solid Pharmaceutical Formulations for the Delivery of Papain Nanoparticles." Pharmaceutics 12, no. 12 (2020): 1170. http://dx.doi.org/10.3390/pharmaceutics12121170.

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Papain is a therapeutic enzyme with restricted applications due to associated allergenic reactions. Papain nanoparticles have shown to be safe for biomedical use, although a method for proper drug loading and release remains to be developed. Thus, the objective of this work was to develop and assess the stability of papain nanoparticles in a prototype semi-solid formulation suitable for dermatological or topical administrations. Papain nanoparticles of 7.0 ± 0.1 nm were synthesized and loaded into carboxymethylcellulose- and poly(vinyl alcohol)-based gels. The formulations were then assayed fo

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Sandhiutami, Ni Made, Yesi Desmiaty, Fahleni Fahleni, Rizqya Handayani, and Windy Ciang. "Enhanced Anti-Inflammatory Activity of Passiflora edulis Leaf Extract Nanoparticle Gel in Carrageenan-Induced Rat Model." Sciences of Pharmacy 4, no. 1 (2025): 32–39. https://doi.org/10.58920/sciphar0401301.

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Passion fruit (Passiflora edulis) leaf extract is rich in flavonoids, which possess anti-inflammatory properties. This study aimed to enhance the anti-inflammatory effect of the extract through a nanoparticle gel formulation. Nanoparticles of the extract (NEP) were prepared using ionic gelation with a Carbomer 940 base. The anti-inflammatory efficacy of NEP was evaluated in vivo using a carrageenan-induced paw edema model in rats. Five groups (n=5) were tested: a negative control (Carbomer 940 gel base), a positive control (Sodium Diclofenac), and three NEP formulations with concentrations of

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RS, Sharan Babu, Sowmya C, Rohith S, Mahalakshmi K, and Monisha K. "Calendula Oil Associated Dexibuprofen Nanoformulation Transdermal Patches: Formulation and Characterization." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 693–98. http://dx.doi.org/10.25258/ijddt.14.2.13.

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Objectives: To prepare and characterize the nanoparticle-based topical formulations of dexibuprofen in combination with calendula oil to enhance the topical anti-inflammatory effect. Methods: Chitosan and tri poly phosphate (TPP) were used to prepare nanoparticles developed utilizing the ionotropic gelation technique and analyzed by scanning electron microscope (SEM) and the ZS. Solvent casting was used to prepare the transdermal medication delivery system for the chitosan nanoparticle formulation. Results: Results revealed that nanoparticles were between the sizes of 267.3 nm. This particle s

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Almehmady, Alshaimaa M., Khalid M. El-Say, Manal A. Mubarak, et al. "Enhancing the Antifungal Activity and Ophthalmic Transport of Fluconazole from PEGylated Polycaprolactone Loaded Nanoparticles." Polymers 15, no. 1 (2022): 209. http://dx.doi.org/10.3390/polym15010209.

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Fungal eye infections are caused mainly by an eye injury and can result in serious eye damage. Fluconazole (FLZ), a broad-spectrum antifungal agent, is a poorly soluble drug with a risk of hepatotoxicity. This work aimed to investigate the antifungal activity, ocular irritation, and transport of FLZ-loaded poly (ε-caprolactone) nanoparticles using a rabbit eye model. Three formulation factors affecting the nanoparticle’s size, zeta potential, and entrapment efficiency were optimized utilizing the Box-Behnken design. Morphological characteristics and antifungal activity of the optimized nanopar

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Bruniera, João Felipe Bonatto, Yara Teresinha Corrêa Silva-Sousa, Marilisa Guimarães Lara, André Pitondo-Silva, Andrea Marcia Marcaccini, and Carlos Eduardo Saraiva Miranda. "Development of Intracanal Formulation Containing Silver Nanoparticles." Brazilian Dental Journal 25, no. 4 (2014): 302–6. http://dx.doi.org/10.1590/0103-6440201302431.

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This study aimed to synthetize, characterize and evaluate the antimicrobial properties of silver nanoparticles to be used in the development of a root intracanal formulation. Silver nanoparticles (AgNPs) were obtained by reduction of silver nitrate with sodium borohydride and characterized by UV-Visible spectrophotometry, scanning electron microscopy (SEM) and dynamic light scattering (DLS). The antimicrobial activity of nanoparticle formulation was evaluated by determinations of the minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against different bacterial

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Hatmayana, Roosma, Syafira Nabillah, Yuditha Windy, and Noval. "Development and Application of Nanoparticle Technology in Herbal Drug Formulation- A Review." International Journal of Education, Science, Technology, and Engineering 4, no. 2 (2021): 72–78. http://dx.doi.org/10.36079/lamintang.ijeste-0402.321.

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Formulations of Herbal medicine are continuously being developed to improve health and treatment through natural ingredients obtained from the surrounding environment with scientific evidence. Common problems in herbal medicine are bioavailability, solubility, absorption of active substances and low stability. Recently, it has become a development trend to enter the realm of nanoparticle technology to its application in herbal drug formulations. Nanoparticle technology is a technology of drug particles are made on the nanoscale (10 nm-1000 nm). Many studies have been carried out on the develop

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Satapathy, Trilochan, Abinash Satapathy, Neha Yadav, Ansuman Satapathy, Kunal Chandrakar, and Shiv Kumar Bhardwaj. "Toxicity and anti-diabetic effectiveness of polymeric nanoparticles containing natural compounds." Journal of Drug Delivery and Therapeutics 13, no. 12 (2023): 113–24. http://dx.doi.org/10.22270/jddt.v13i12.6089.

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Objective: To develop the nanoparticle formulations, characterization and evaluation of safety and in vivo anti diabetic potential by using experimental animal model. Methods: Different nano formulations such as Cur-nanoparticles, Pip-nanoparticles as well as Cur-Pip dual drug loaded nanoparticles were developed by nano co-precipitation method. The developed formulations were subjected for FT-IR analysis to determine the drug-drug and drug-polymer interaction. The Differential Scanning Colorimetric (DSC) study was carried out to observe the glass transition. Surface topography of nano fo

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Ramesh, Yerikala, Koorapati Balasaradhi, and Kaki Rohan Abhilash. "Formulation and evaluation of albendazole nanoparticle." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 16–22. http://dx.doi.org/10.22270/jddt.v9i1-s.2239.

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Therefore, there is a need to develop alternative novel drug delivery formulations of albendazole to improve its intestinal absorption and also to reduce its side effects during regular therapy. The Albendazole nanoparticles were prepared by hot homogenization method under high magnetic stirring using stearic acid as lipid and poloxamer 188 was used as surfactant. Initial pre-formulation studies using FTIR spectroscopy reveals that there are no interactions between Albendazole and other excipients and hence they can be used for the preparation of nanoparticles. The entrapment efficiencies vari

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KAUR, CHANCHAL DEEP, GYANESH SAHU, SWARNALI DAS PAUL, HARISH SHARMA, and AJAZUDDIN . "DESIGN AND CHARACTERIZATION OF PACLITAXEL LOADED NANOPARTICLES WITH PIPERINE." International Journal of Pharmaceutical Sciences and Drug Research 14, no. 02 (2020): 238–43. http://dx.doi.org/10.25004/ijpsdr.2022.140213.

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Objectives: Paclitaxel is a cytotoxic drug having wonderful mechanism against cancer cells. However, it showed severe dose-limiting toxicity when administered as infusion. To overcome these side effects a suitable delivery system is highly desirable. Bioenhancers, when mixed with drugs promote and augment their bioavailability and reduced incidence of drug resistance and risk of adverse drug reaction. Therefore, we selected nanoparticles as a delivery system in this study. The object of this work was to entrap paclitaxel and herbal bioenhancer in a nanoparticle system. Materials and methods: W

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Hidayati, Evi Nurul, Annisa Maulidia Rahayyu, and Eni Masruriati. "Nanoparticle formulation of ethanolic extract of Syzygium polyanthum leaf using chitosan and cross-linking method." Pharmaciana 15, no. 1 (2025): 132–42. https://doi.org/10.12928/pharmaciana.v15i1.25834.

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Syzygium polyanthum (bay leaves) is widely used in Indonesia and has been shown to have pharmacological activity, such as antihyperlipidemia. The nanoparticle is a delivery system that enhances therapy effectiveness, minimizes side effects, and ensures safety. Therefore, this study aimed to improve the antihyperlipidemic efficacy of Syzygium polyanthum extract by formulating it into nanoparticles. The polymer that is used in this nanoparticle formulation is chitosan, while the cross-linking agent that is used is sodium tripolyphosphate. Three formulations have been developed, each with differe

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Card, Jeffrey W., and Bernadene A. Magnuson. "A review of the efficacy and safety of nanoparticle-based oral insulin delivery systems." American Journal of Physiology-Gastrointestinal and Liver Physiology 301, no. 6 (2011): G956—G967. http://dx.doi.org/10.1152/ajpgi.00107.2011.

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Nanotechnology is providing new and innovative means to detect, diagnose, and treat disease. In this regard, numerous nanoparticle-based approaches have been taken in an effort to develop an effective oral insulin therapy for the treatment of diabetes. This review summarizes efficacy data from studies that have evaluated oral insulin therapies in experimental models. Also provided here is an overview of the limited safety data that have been reported in these studies. To date, the most promising approaches for nanoparticle-based oral insulin therapy appear to involve the incorporation of insul

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Kumar, Ajay, Abhishek Soni, Ashish Kumar, ,. Yashpal, and Jyoti Devi. "Preparation of Luliconazole loaded silver nanoparticles Topical gel." Journal of Drug Delivery and Therapeutics 12, no. 4 (2022): 31–35. http://dx.doi.org/10.22270/jddt.v12i4.5424.

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After optimization of the luliconazole loaded silver nanoparticles formulation it was given a gel base for topical delivery the silver nanoparticles have a very low viscosity. The gel was formed by varying the concentration of carbopol 940 as 0.75%, 1. %, 2%. The optimized luliconazole loaded silver nanoparticles formulation LSN14 was incorporated into different concentration carbopol gel base of different concentrations of carbopol and evaluated for various in vitro characterization parameters homogeneity, grittiness, measurement of pH, drug content, viscosity study, Spreadibility, in - vitro

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Kosasih, Kosasih, and Nesshi Alifiya. "Spray-gel formulations of Cantigi extract and Cantigi extract-loaded gelatin nanoparticles as antioxidant." JURNAL ILMU KEFARMASIAN INDONESIA 22, no. 1 (2024): 38. http://dx.doi.org/10.35814/jifi.v22i1.1586.

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Spray-gel formulations may contain natural antioxidants like plant extracts. They can reduce free radicals and prevent premature aging. This research aims to study spray-gel formulations using Cantigi extracts and Cantigi extract-loaded gelatin nanoparticles as antioxidants. Extract preparation used the maceration method concentrated by a rotavapor and characterized for specific and nonspecific parameters. Antioxidant activity analysis of extract, nanoparticles, and formulations used the DPPH method. Gelatin nanoparticle synthesis was done using the nanoprecipitation method and then characteri

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Foglizzo, Valentina, and Serena Marchiò. "Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy." Cancers 14, no. 10 (2022): 2473. http://dx.doi.org/10.3390/cancers14102473.

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Malignant tumors originate from a combination of genetic alterations, which induce activation of oncogenes and inactivation of oncosuppressor genes, ultimately resulting in uncontrolled growth and neoplastic transformation. Chemotherapy prevents the abnormal proliferation of cancer cells, but it also affects the entire cellular network in the human body with heavy side effects. For this reason, the ultimate aim of cancer therapy remains to selectively kill cancer cells while sparing their normal counterparts. Nanoparticle formulations have the potential to achieve this aim by providing optimiz

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S., Nikam Supriya, Phadatare Priya P., Watode Ankita B., and Kalyani Kayande. "NANOSTRUCTURED LIPID CARRIERS: A PROMISING APPROACH FOR TOPICAL DRUG DELIVERY SYSTEM." International Journal of Pharmaceutical Sciences and Medicine 6, no. 7 (2021): 81–101. http://dx.doi.org/10.47760/ijpsm.2021.v06i07.007.

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Nanostructured lipid carriers (NLCs) are innovative pharmaceutical formulations made up of physiological and biocompatible lipids, as well as surfactants and co-surfactant. The initial generation of lipid nanoparticles was Solid Lipid Nanoparticles (SLN), which had a longer-lasting activity and was better, suited to drug penetration. The NLC is a second-generation lipid nanoparticle designed to alleviate the limitations of SLN, such as limited drug loading capacity and solid lipid polymorphism. Many benefits of topical medication delivery include avoiding first-pass metabolism, focusing active

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Moribe, Kunikazu, Waree Limwikrant, Kenjirou Higashi, and Keiji Yamamoto. "Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives." Journal of Drug Delivery 2011 (April 26, 2011): 1–9. http://dx.doi.org/10.1155/2011/138929.

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Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients. In addition to drug solubilization, drug nanoparticle formation was observed using ascorbyl glycoside. Hydrophobic ascorbic acid derivatives such as ascorbyl mono- and di-n-alkyl fatty acid derivatives are used either as drugs or carrier components. Ascorbyl n-alkyl fatty acid derivatives have been formulated as antioxidants or

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Varympopi, Adamantia, Anastasia Dimopoulou, Dimitris Papafotis, et al. "Antibacterial Activity of Copper Nanoparticles against Xanthomonas campestris pv. vesicatoria in Tomato Plants." International Journal of Molecular Sciences 23, no. 8 (2022): 4080. http://dx.doi.org/10.3390/ijms23084080.

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Copper-based bactericides have appeared as a new tool in crop protection and offer an effective solution to combat bacterial resistance. In this work, two copper nanoparticle products that were previously synthesized and evaluated against major bacterial and fungal pathogens were tested on their ability to control the bacterial spot disease of tomato. Growth of Xanthomonas campestris pv. vesicatoria, the causal agent of the disease, was significantly suppressed by both nanoparticles, which had superior function compared to conventional commercial formulations of copper. X-ray fluorescence spec

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Giaretta, Mosiele, Mariana Domingues Bianchin, Luiz Alberto Kanis, Renata Vidor Contri, and Irene Clemes Külkamp-Guerreiro. "Development of Innovative Polymer-Based Matricial Nanostructures for Ritonavir Oral Administration." Journal of Nanomaterials 2019 (February 26, 2019): 1–10. http://dx.doi.org/10.1155/2019/8619819.

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Ritonavir is used in the treatment of pediatric human immunodeficiency virus infection. The aim of this study was to develop and evaluate innovative polymer-based matricial nanostructures containing ritonavir for a sustained delivery. Two formulations were prepared by interfacial deposition of preformed polymers using Eudragit® RS100 in combination with Polycaprolactone triol 300 (NPR-300) or Polycaprolactone triol 900 (NPR-900). Ritonavir (1 mg mL-1) was incorporated in the formulations. NPR-300 showed a mean size of 559 nm, SPAN of 1.66, zeta potential of 5.9 mV, pH of 4.23, drug content of

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Simpson, Elliot, Humera Sarwar, Iain Jack, and Deborah Lowry. "Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the Treatment of Osteomyelitis." Antibiotics 13, no. 3 (2024): 208. http://dx.doi.org/10.3390/antibiotics13030208.

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Chitosan nanoparticle delivery systems have the potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to 400 nm), PDI (less than 0.5), zeta potential (typically negative), and in vitro release profiles for gentamicin. Entrapment percentages varied with gentamicin ranging from 10% to 65%. The chitosan nanoparticles exhibited substantial antimicrobial efficacy, particularly against P. a

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Deshkar, Sanjeevani, Sumit Sikchi, Anjali Thakre, and Rupali Kale. "Poloxamer Modified Chitosan Nanoparticles for Vaginal Delivery of Acyclovir." Pharmaceutical Nanotechnology 9, no. 2 (2021): 141–56. http://dx.doi.org/10.2174/2211738508666210108121541.

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Objective: The aim of the present study was to design a surface modified chitosan nanoparticle system for vaginal delivery of acyclovir for effective drug uptake into vaginal mucosa. Method: Acyclovir-loaded chitosan nanoparticles, with and without modification by poloxamer 407, were prepared by ionic gelation method. The effects of two independent variables, chitosan to sodium tripolyphosphate mass ratio (X1) and acyclovir concentration (X2), on drug entrapment in nanoparticles were studied using 32 full factorial design. The surface response and counterplots were drawn to facilitate an under

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Akbar, Noor, Muhammad Kawish, Naveed Ahmed Khan, et al. "Hesperidin-, Curcumin-, and Amphotericin B- Based Nano-Formulations as Potential Antibacterials." Antibiotics 11, no. 5 (2022): 696. http://dx.doi.org/10.3390/antibiotics11050696.

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To combat the public health threat posed by multiple-drug-resistant (MDR) pathogens, new drugs with novel chemistry and modes of action are needed. In this study, several drugs including Hesperidin (HES), curcumin (CUR), and Amphotericin B (AmpB) drug–nanoparticle formulations were tested for antibacterial strength against MDR Gram-positive bacteria, including Bacillus cereus, Streptococcus pyogenes, Methicillin-resistant Staphylococcus aureus (MRSA), and Streptococcus pneumoniae, and Gram-negative bacteria, including Escherichia coli K1, Pseudomonas aeruginosa, Salmonella enterica, and Serrat

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Amaravathi Vyshanavi, N. Pradeep kumar, C. Manjula, and A. Srikanth. "Quality by design approach for development and optimization of rifampicin loaded nanoparticles and characterization." World Journal of Biology Pharmacy and Health Sciences 16, no. 3 (2023): 124–37. http://dx.doi.org/10.30574/wjbphs.2023.16.3.0468.

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Background: Rifampicin is an effective in the treatment of sensitive, non-resistant strains of mycobacterium tuberculosis. Thus there is need to develop a rifampicin loaded nanoparticles. Aim: This study is focused on development of RFM loaded nanoparticles, characterization to achieve lung targeting using quality by design approach. Objectives: The main objective of this study is optimizing particle size and entrapment efficiency of rifampicin-loaded nanoparticles and making them suitable for nebulizer application using QbD approach. Methods: Quality target product profile was defined along w

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Straehla, Joelle, Natalie Boehnke, Hannah Safford, et al. "DDEL-17. POOLED CANCER CELL SCREENING IDENTIFIES GENOMIC DETERMINANTS OF NANOPARTICLE DELIVERY TO CANCER CELLS: SUB ANALYSIS OF CENTRAL NERVOUS SYSTEM TUMOR CELL LINES." Neuro-Oncology 24, Supplement_7 (2022): vii97. http://dx.doi.org/10.1093/neuonc/noac209.363.

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Abstract Background There is great interest in utilizing nanoparticles to improve drug delivery to central nervous system (CNS) tumors, but the biologic features underlying successful delivery at the tumor site are not known. METHODS We developed a pooled screening assay to investigate cellular features predictive of nanoparticle delivery and screened 35 fluorescent nanoparticle formulations against 488 pooled cancer cell lines with DNA barcodes. The nanoparticle library was comprised of nonlethal liposomal or polymeric cores with varied surface functionality, including natural and synthetic p

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Bhuvaneshwaran, Purushothaman, and Ramaiyan Velmurugan. "Development, optimization, and evaluation of Cisplatin-loaded PLGA nanoparticles." Characterization and Application of Nanomaterials 5, no. 2 (2022): 99. http://dx.doi.org/10.24294/can.v5i2.1768.

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Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug

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Kamiya, Seitaro, Maya Yamada, Miki Washino, and Kenichiro Nakashima. "Preparation of Nanoparticles Including Antisolvent Drugs by the Combination of Roll Milling and High-pressure Homogenization." Current Nanoscience 14, no. 2 (2018): 143–47. http://dx.doi.org/10.2174/1573413713666171109155955.

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Description: Design methods of nanoparticle formulations are divided into break-down methods and build-up methods. The former is further divided into dry and wet processes. For drug nanoparticle preparations, the wet process is generally employed, and organic solvents are used in most formulations. Method: In this study, we investigate the preparation of nifedipine (IB) and griseofulvin (GF) nanoparticles without using organic solvent. Both IB and GF nanoparticles, with a mean particle size of approximately 50 nm, were prepared without organic solvent by employing a combination of roll milling

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Peddappi Reddigari, Jayachandra Reddy, Yerikala Ramesh, and Chandrasekhar B. Kothapalli. "Formulation and evaluation of in-situ gels enriched with Tropicamide loaded solid lipid nanoparticles." International Journal of Research in Pharmaceutical Sciences 9, no. 1 (2018): 216. http://dx.doi.org/10.26452/ijrps.v9i1.1250.

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The present research work “Formulation and Evaluation of In-situ gels enriched with Tropicamide loaded solid lipid nanoparticles”. To overcome the problems of side effects and to increase the bioavailability of tropicamide loaded solid lipid nanoparticles are containing with suitable lipids (glycerin trimyristate, Tristearin, Phosphatidylcholine & soyabean lecithin) with stabilizers (poloxamer 188) and surfactant like polysorbate 80. The interaction between drug, lipids & polymer by performing with FTIR no incompatibility with each other. The particle morphology was carried out by SEM

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Alsultan, Saleh Suliman, Abdullah Saeed Alasmari, Mohammed Ibrahim Abdullah Alfayez, Salama Nasser Ibrahim Alkhamis, and Khaled Alfuraieh. "Recent Advances in Nanoformulation for Targeted Drug Delivery Systems." Journal of Advances and Scholarly Researches in Allied Education 22, no. 01 (2025): 63–81. https://doi.org/10.29070/yxrwqa98.

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Intravascular medication delivery allows nanoparticles to enter the circulation via blood vessels and treat intravascular illnesses by acting at precise locations inside the blood vessels. Another method of drug delivery including nanoparticles is known as extravascular drug delivery, and it involves local administration (e.g., oral, inhalation, subcutaneous injection, etc.) to target tissues. Utilising the principles of nanotechnology, nano pharmaceuticals have completely transformed the way drugs are delivered and treatment approaches in contemporary medicine. Utilising nanoparticles (NPs) a

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Ramadhani, Pratidina Fitri, Sri Lelyati C. Masulili, Robert Lessang, Dian Fitri Chairunnisa, and Padmini Hari. "Synergistic antibacterial effects of aloe vera doped with Chitosan against Porphyromonas gingivalis as a natural periodontal inflammatory remedy." International Journal of Innovative Research and Scientific Studies 8, no. 3 (2025): 3922–32. https://doi.org/10.53894/ijirss.v8i3.7404.

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With the rise of antibiotic resistance, there is growing interest in developing herbal treatments for periodontal inflammation. Aloe vera has attracted scientific interest for its therapeutic potential, although formulating effective herbal medicines remains a challenge. Chitosan-based nanoparticles offer a promising strategy to enhance the delivery of herbal compounds. This study investigates the combination of Aloe vera extract and chitosan nanoparticles to create a potent antibacterial agent targeting Porphyromonas gingivalis, while also assessing its toxicity on BHK-21 fibroblast cells. Th

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Kenny-Serrano, Julianna, Elizabeth B. Nelson, Gil Covarrubias, et al. "Abstract 492: Investigating solute carrier SLC46A3 to enhance nanotherapeutic delivery for cancer." Cancer Research 84, no. 6_Supplement (2024): 492. http://dx.doi.org/10.1158/1538-7445.am2024-492.

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Abstract BACKGROUND: Nanoparticle therapeutics have multifaceted potential to improve efficacy and decrease toxicity of cancer treatments. Nanotherapeutics can encapsulate a range of cargos and have tunable surface chemistry that can enhance drug delivery to tumors. Cellular features also play a role in successful drug delivery, and predictive biomarkers may improve patient selection for clinical trials. In previous work, we identified SLC46A3, a poorly characterized lysosomal solute carrier, as a strong negative regulator of lipid-based nanoparticle uptake across many cancer models. We hypoth

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Abdus Samad, Ubair, Mohammad Asif Alam, Arfat Anis, El-Sayed M. Sherif, Sulaiman I. Al-Mayman, and Saeed M. Al-Zahrani. "Effect of Incorporated ZnO Nanoparticles on the Corrosion Performance of SiO2 Nanoparticle-Based Mechanically Robust Epoxy Coatings." Materials 13, no. 17 (2020): 3767. http://dx.doi.org/10.3390/ma13173767.

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This paper presents the studies of the development of a high-performance epoxy coating for steel substrates. To this end, it investigated the synergistic effect of incorporating zinc oxide (ZnO) nanoparticles into nanosilica containing epoxy formulations. The mechanical properties of the epoxy coating formulations were improved by modifying the surfaces of the silica nanoparticles (5 wt.%) with 3-glycidoxypropyl trimethoxysilane, which ensured their dispersal through the material. Next, the ZnO nanoparticles (1, 2, or 3 wt.%) were incorporated to improve the corrosion performance of the formul

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Murji, Amyn A., Juliana S. Qin, Tandile Hermanus, Lynn Morris, and Ivelin S. Georgiev. "Elicitation of Neutralizing Antibody Responses to HIV-1 Immunization with Nanoparticle Vaccine Platforms." Viruses 13, no. 7 (2021): 1296. http://dx.doi.org/10.3390/v13071296.

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A leading strategy for developing a prophylactic HIV-1 vaccine is the elicitation of antibodies that can neutralize a large fraction of circulating HIV-1 variants. However, a major challenge that has limited the effectiveness of current vaccine candidates is the extensive global diversity of the HIV-1 envelope protein (Env), the sole target for HIV-neutralizing antibodies. To address this challenge, various strategies incorporating Env diversity into the vaccine formulation have been proposed. Here, we assessed the potential of two such strategies that utilize a nanoparticle-based vaccine plat

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