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Journal articles on the topic 'Nanostructured materials Proteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Kamada, Ayaka, Nitesh Mittal, L. Daniel Söderberg, et al. "Flow-assisted assembly of nanostructured protein microfibers." Proceedings of the National Academy of Sciences 114, no. 6 (2017): 1232–37. http://dx.doi.org/10.1073/pnas.1617260114.

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Some of the most remarkable materials in nature are made from proteins. The properties of these materials are closely connected to the hierarchical assembly of the protein building blocks. In this perspective, amyloid-like protein nanofibrils (PNFs) have emerged as a promising foundation for the synthesis of novel bio-based materials for a variety of applications. Whereas recent advances have revealed the molecular structure of PNFs, the mechanisms associated with fibril–fibril interactions and their assembly into macroscale structures remain largely unexplored. Here, we show that whey PNFs ca

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Domach, Michael M., and Lynn M. Walker. "Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials." JALA: Journal of the Association for Laboratory Automation 15, no. 2 (2010): 136–44. http://dx.doi.org/10.1016/j.jala.2010.01.002.

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Increases in the use of protein-based pharmaceuticals require the development of cost-effective methods of storage and transport of sensitive biomolecules. In this article, we review the general problems of protein stabilization, aspects specific to antibodies, and a proposed method for protecting proteins based on nanostructured hydrogels. This review is not intended to be comprehensive, but instead to provide the reader with specific examples that capture some of the key challenges and opportunities of the field.

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Grove, Tijana Z., Lynne Regan, and Aitziber L. Cortajarena. "Nanostructured functional films from engineered repeat proteins." Journal of The Royal Society Interface 10, no. 83 (2013): 20130051. http://dx.doi.org/10.1098/rsif.2013.0051.

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Fundamental advances in biotechnology, medicine, environment, electronics and energy require methods for precise control of spatial organization at the nanoscale. Assemblies that rely on highly specific biomolecular interactions are an attractive approach to form materials that display novel and useful properties. Here, we report on assembly of films from the designed, rod-shaped, superhelical, consensus tetratricopeptide repeat protein (CTPR). We have designed three peptide-binding sites into the 18 repeat CTPR to allow for further specific and non-covalent functionalization of films through

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Zhang, Shuguang, Davide M. Marini, Wonmuk Hwang, and Steve Santoso. "Design of nanostructured biological materials through self-assembly of peptides and proteins." Current Opinion in Chemical Biology 6, no. 6 (2002): 865–71. http://dx.doi.org/10.1016/s1367-5931(02)00391-5.

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Guo, Guilue, Yuanyuan Guo, Huiteng Tan, et al. "From fibrous elastin proteins to one-dimensional transition metal phosphides and their applications." Journal of Materials Chemistry A 4, no. 28 (2016): 10893–99. http://dx.doi.org/10.1039/c6ta04150g.

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Colilla, Montserrat, Isabel Izquierdo-Barba, and María Vallet-Regí. "The Role of Zwitterionic Materials in the Fight against Proteins and Bacteria." Medicines 5, no. 4 (2018): 125. http://dx.doi.org/10.3390/medicines5040125.

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Zwitterionization of biomaterials has been heightened to a potent tool to develop biocompatible materials that are able to inhibit bacterial and non-specific proteins adhesion. This constitutes a major progress in the biomedical field. This manuscript overviews the main functionalization strategies that have been reported up to date to design and develop these advanced biomaterials. On this regard, the recent research efforts that were dedicated to provide their surface of zwitterionic nature are summarized by classifying biomaterials in two main groups. First, we centre on biomaterials in cli

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Márquez, J., M. De la Cruz-Guzmán, L. F. Cházaro, and G. Palestino. "Porous Silicon Nanostructured Materials for Sensing Applications: Molecular Assembling and Electrochemical or Optical Evaluation." MRS Proceedings 1812 (2016): 77–82. http://dx.doi.org/10.1557/opl.2016.21.

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ABSTRACTPorous silicon (PSi) combines the potential of miniaturization with a very large surface area. The PSi surface can be chemically modified resulting in a high sensitivity (low detection threshold) device for chemical and biomolecular sensing. In previous work, we have shown that redox proteins and fluorescent ligands can be infiltrated into PSi (PSiMc) structures. The hybrid devices have shown interesting new properties produced by the coupling of the individual properties of PSi nanostructures and the modifiers. In this work, we have obtained a PSiMc/redox protein bioelectrode, which p

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Messina, Grazia M. L., Gianfranco Bocchinfuso, Nicoletta Giamblanco, Claudia Mazzuca, Antonio Palleschi, and Giovanni Marletta. "Orienting proteins by nanostructured surfaces: evidence of a curvature-driven geometrical resonance." Nanoscale 10, no. 16 (2018): 7544–55. http://dx.doi.org/10.1039/c8nr00037a.

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9

Gholami, Ahmad, Seyyed Alireza Hashemi, Khadije Yousefi, et al. "3D Nanostructures for Tissue Engineering, Cancer Therapy, and Gene Delivery." Journal of Nanomaterials 2020 (November 30, 2020): 1–24. http://dx.doi.org/10.1155/2020/1852946.

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The self-assembling is a spontaneous progression through which objects of nanophase/molecules materialize into prepared collections. Several biomolecules can interact and assemble into highly structured supramolecular structures, for instance, proteins and peptides, with fibrous scaffolds, helical ribbons, and many other functionalities. Various self-assembly systems have been established, from copolymers in blocks to three-dimensional (3D) cell culture scaffolds. Another advantage of self-assembly is its ability to manage a large variety of materials, including metals, oxides, inorganic salts

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Wu, Aiguo, Zhihong Jia, Andreas Schaper, Frank Noll, and Norbert A. Hampp. "Simultaneous Removal of Thiolated Membrane Proteins Resulting in Nanostructured Lipid Layers." Langmuir 22, no. 12 (2006): 5213–16. http://dx.doi.org/10.1021/la053162n.

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11

Li, H., Khiam Aik Khor, W. N. Chen, T. L. Tan, H. Pan, and P. Cheang. "Proteomics Study of the Osteoblast Cells Proliferated on Nanostructured Hydroxyapatite Coatings." Key Engineering Materials 330-332 (February 2007): 381–84. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.381.

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A big variety of bioceramics have been successfully utilized as implant materials for promoting fixation of bony tissues. Different bioceramics exhibited markedly different proliferation rates of the osteoblast cells in vitro. Clarification of the mechanism about the attachment and proliferation/differentiation of the cells would contribute to selecting suitable biomaterials for hard tissue replacement. Proteomics study was performed in this study employing the 2-dimensional electrophoresis assay with an aim of recognizing the changes in proteins. Nanostructured hydroxyapatite (HA) coatings ha

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Fohlerova, Zdenka, and Alexander Mozalev. "Anodic formation and biomedical properties of hafnium-oxide nanofilms." Journal of Materials Chemistry B 7, no. 14 (2019): 2300–2310. http://dx.doi.org/10.1039/c8tb03180k.

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13

Vijayaraj, Munusami, Roger Gadiou, Karine Anselme, et al. "The Influence of Surface Chemistry and Pore Size on the Adsorption of Proteins on Nanostructured Carbon Materials." Advanced Functional Materials 20, no. 15 (2010): 2489–99. http://dx.doi.org/10.1002/adfm.201000288.

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Li, Ting, Jialu Yu, Hao Sui, Tao Zhang, and Ronghui Zhou. "Bovine Serum Albumin-Directed Fabrication of Nanohydroxyapatite with Improved Stability and Biocompatibility." International Journal of Nanoscience 20, no. 03 (2021): 2150028. http://dx.doi.org/10.1142/s0219581x21500289.

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Nanohydroxyapatite (nHAp) has gained considerable concerns due to its vast potential in biomedical applications such as drug delivery, tissue engineering and bone repair. However, the preparation of HAp nanostructures in a controllable manner under environment-friendly reaction conditions remains a challenge. In recent years, the use of biological macromolecules or proteins as templates in the production of nanomaterials has gained more attention due to the relatively mild physical conditions needed for biomimetic synthesis. In this study, a novel nHAp was fabricated by employing bovine serum

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Vrlinic, Tjasa, Dominique Debarnot, Gilbert Legeay, et al. "Non-Adhesive Behavior of New Nanostructured PNIPAM Surfaces Towards Specific Neurodegenerative Proteins: Application to Storage and Titration of Tau Proteins." Macromolecular Bioscience 12, no. 10 (2012): 1354–63. http://dx.doi.org/10.1002/mabi.201200116.

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Lu, Yidong, Jingjing Xu, Yuan Liu, et al. "Manipulated photocurrent generation from pigment-exchanged photosynthetic proteins adsorbed to nanostructured WO3–TiO2 electrodes." Chemical Communications, no. 7 (2006): 785. http://dx.doi.org/10.1039/b514606b.

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Ray, Krishanu, Mustafa H. Chowdhury, Henryk Szmacinski, and Joseph R. Lakowicz. "Metal-Enhanced Intrinsic Fluorescence of Proteins on Silver Nanostructured Surfaces toward Label-Free Detection." Journal of Physical Chemistry C 112, no. 46 (2008): 17957–63. http://dx.doi.org/10.1021/jp807025n.

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Lichtenstein, Bruce R., Tammer A. Farid, Goutham Kodali, et al. "Engineering oxidoreductases: maquette proteins designed from scratch." Biochemical Society Transactions 40, no. 3 (2012): 561–66. http://dx.doi.org/10.1042/bst20120067.

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The study of natural enzymes is complicated by the fact that only the most recent evolutionary progression can be observed. In particular, natural oxidoreductases stand out as profoundly complex proteins in which the molecular roots of function, structure and biological integration are collectively intertwined and individually obscured. In the present paper, we describe our experimental approach that removes many of these often bewildering complexities to identify in simple terms the necessary and sufficient requirements for oxidoreductase function. Ours is a synthetic biology approach that fo

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Mitchell, Michael J., Carlos A. Castellanos, and Michael R. King. "Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes." Journal of Nanomaterials 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/831263.

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Hematogenous metastasis, the process of cancer cell migration from a primary to distal location via the bloodstream, typically leads to a poor patient prognosis. Selectin proteins hold promise in delivering drug-containing nanocarriers to circulating tumor cells (CTCs) in the bloodstream, due to their rapid, force-dependent binding kinetics. However, it is challenging to deliver such nanocarriers while avoiding toxic effects on healthy blood cells, as many possess ligands that adhesively interact with selectins. Herein, we describe a nanostructured surface to capture flowing cancer cells, whil

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Yan, Xiaomei, Jing Tang, David Tanner, Jens Ulstrup, and Xinxin Xiao. "Direct Electrochemical Enzyme Electron Transfer on Electrodes Modified by Self-Assembled Molecular Monolayers." Catalysts 10, no. 12 (2020): 1458. http://dx.doi.org/10.3390/catal10121458.

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Self-assembled molecular monolayers (SAMs) have long been recognized as crucial “bridges” between redox enzymes and solid electrode surfaces, on which the enzymes undergo direct electron transfer (DET)—for example, in enzymatic biofuel cells (EBFCs) and biosensors. SAMs possess a wide range of terminal groups that enable productive enzyme adsorption and fine-tuning in favorable orientations on the electrode. The tunneling distance and SAM chain length, and the contacting terminal SAM groups, are the most significant controlling factors in DET-type bioelectrocatalysis. In particular, SAM-modifi

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Neupane, Dharmendra, and Keith J. Stine. "Electrochemical Sandwich Assays for Biomarkers Incorporating Aptamers, Antibodies and Nanomaterials for Detection of Specific Protein Biomarkers." Applied Sciences 11, no. 15 (2021): 7087. http://dx.doi.org/10.3390/app11157087.

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The development of sensitive and selective assays for protein biomarkers and other biological analytes is important for advancing the fields of clinical diagnostics and bioanalytical chemistry. The potential advantages of using aptamers in electrochemical sandwich assays are being increasingly recognized. These assays may include an aptamer as both capture and detection agent or a combination of an aptamer with a different partner such as an antibody, a lectin or a nanomaterial. The second binding partner in the sandwich structure is typically conjugated to a redox marker, a catalyst or an enz

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Frasconi, Marco, Daniela Deriu, Andrea D’Annibale, and Franco Mazzei. "Nanostructured materials based on the integration of ferrocenyl-tethered dendrimer and redox proteins on self-assembled monolayers: an efficient biosensor interface." Nanotechnology 20, no. 50 (2009): 505501. http://dx.doi.org/10.1088/0957-4484/20/50/505501.

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Kattimani, Vivekanand Sabanna, Sudheer Kondaka, and Krishna Prasad Lingamaneni. "Hydroxyapatite–-Past, Present, and Future in Bone Regeneration." Bone and Tissue Regeneration Insights 7 (January 2016): BTRI.S36138. http://dx.doi.org/10.4137/btri.s36138.

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Hydroxyapatite (HA) is an essential element required for bone regeneration. Different forms of HA have been used for a long time. The essence of bone regeneration always revolves around the healthy underlying bone or it may be the surroundings that give enough strength. HA is well known for bone regeneration through conduction or by acting as a scaffold for filling of defects from ancient times, but emerging trends of osteoinductive property of HA are much promising for new bone regeneration. Emerging technology has made the dreams of clinicians to realize the use of HA in different forms for

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Wicklein, Bernd, Margarita Darder, Pilar Aranda, et al. "Clay-lipid nanohybrids: towards influenza vaccines and beyond." Clay Minerals 51, no. 4 (2016): 529–38. http://dx.doi.org/10.1180/claymin.2016.051.4.01.

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AbstractThe design of nanostructured materials based on natural components, such as clay minerals, offers new solutions to biomedical challenges such as more efficient and storage-stable vaccines. Clay-lipid hybrid materials have proved useful as adjuvants in influenza vaccines and with a possible projection to leishmaniasis vaccines and other pathogens. Self-assembly of phospholipid molecules on the surface of microfibrous sepiolite and lamellar Mg/Al layered double hydroxide renders a biocompatible lipid bilayer membrane that ensures non-degrading immobilization of proteins and other biologi

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Kahraman, Mehmet, Emma R. Mullen, Aysun Korkmaz, and Sebastian Wachsmann-Hogiu. "Fundamentals and applications of SERS-based bioanalytical sensing." Nanophotonics 6, no. 5 (2017): 831–52. http://dx.doi.org/10.1515/nanoph-2016-0174.

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AbstractPlasmonics is an emerging field that examines the interaction between light and metallic nanostructures at the metal-dielectric interface. Surface-enhanced Raman scattering (SERS) is a powerful analytical technique that uses plasmonics to obtain detailed chemical information of molecules or molecular assemblies adsorbed or attached to nanostructured metallic surfaces. For bioanalytical applications, these surfaces are engineered to optimize for high enhancement factors and molecular specificity. In this review we focus on the fabrication of SERS substrates and their use for bioanalytic

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Zyuzin, Mikhail V., Dingcheng Zhu, Wolfgang J. Parak, Neus Feliu, and Alberto Escudero. "Development of Silica-Based Biodegradable Submicrometric Carriers and Investigating Their Characteristics as in Vitro Delivery Vehicles." International Journal of Molecular Sciences 21, no. 20 (2020): 7563. http://dx.doi.org/10.3390/ijms21207563.

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Nanostructured silica (SiO2)-based materials are attractive carriers for the delivery of bioactive compounds into cells. In this study, we developed hollow submicrometric particles composed of SiO2 capsules that were separately loaded with various bioactive molecules such as dextran, proteins, and nucleic acids. The structural characterization of the reported carriers was conducted using transmission and scanning electron microscopies (TEM/SEM), confocal laser scanning microscopy (CLSM), and dynamic light scattering (DLS). Moreover, the interaction of the developed carriers with cell lines was

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Osella, Silvio. "Artificial Photosynthesis: Is Computation Ready for the Challenge Ahead?" Nanomaterials 11, no. 2 (2021): 299. http://dx.doi.org/10.3390/nano11020299.

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A tremendous effort is currently devoted to the generation of novel hybrid materials with enhanced electronic properties for the creation of artificial photosynthetic systems. This compelling and challenging problem is well-defined from an experimental point of view, as the design of such materials relies on combining organic materials or metals with biological systems like light harvesting and redox-active proteins. Such hybrid systems can be used, e.g., as bio-sensors, bio-fuel cells, biohybrid photoelectrochemical cells, and nanostructured photoelectronic devices. Despite these efforts, the

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Miralami, Raheleh, Laura Koepsell, Thyagaseely Premaraj, et al. "Comparing Biocompatibility of Nanocrystalline Titanium and Titanium-Oxide with Microcrystalline Titanium." MRS Proceedings 1569 (2013): 91–96. http://dx.doi.org/10.1557/opl.2013.804.

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ABSTRACTTitanium (Ti) is the material of choice for orthopaedic applications because it is biocompatible and encourages osteoblast ingrowth. It was shown that the biocompatibility of Ti metal is due to the presence of a thin native sub-stoichiometric titanium oxide layer which enhances the adsorption of mediating proteins on the surface [1]. The present studies were devised to evaluate the adhesion, survival, and growth of cells on the surface of new engineered nano-crystal films of titanium and titanium oxides and compare them with orthopaedic-grade titanium with microcrystals. The engineered

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Ghaeini-Hesaroeiye, Sobhan, Hossein Razmi Bagtash, Soheil Boddohi, Ebrahim Vasheghani-Farahani, and Esmaiel Jabbari. "Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications." Gels 6, no. 3 (2020): 20. http://dx.doi.org/10.3390/gels6030020.

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Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing

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Pieklarz, Katarzyna, Michał Tylman, and Zofia Modrzejewska. "APPLICATIONS OF CHITOSAN–GRAPHENE OXIDE NANOCOMPOSITES IN MEDICAL SCIENCE: A REVIEW." Progress on Chemistry and Application of Chitin and its Derivatives XXIII (September 10, 2018): 5–24. http://dx.doi.org/10.15259/pcacd.23.001.

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Combinations of biopolymers with nanostructured carbon materials have been the subject of interest of many scientists in recent years. Particularly significant are nanocomposites made of chitosan, which is a linear aminopolysaccharide obtained in the process of deacetylation of chitin, and graphene oxide (GO). These systems, due to the atypical properties of both components such as non-toxicity, biocompatibility with human tissues and organs as well as bacteriostaticity, are characterised by a wide range of biomedical applications. They may be used in emergency medicine as dressing materials w

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Lin, Donghai, Kenneth D. Harris, Nora W. C. Chan, and Abebaw B. Jemere. "Nanostructured indium tin oxide electrodes immobilized with toll-like receptor proteins for label-free electrochemical detection of pathogen markers." Sensors and Actuators B: Chemical 257 (March 2018): 324–30. http://dx.doi.org/10.1016/j.snb.2017.10.140.

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Watt, Gerald D., Jae-Woo Kim, Bo Zhang, et al. "A Protein-Based Ferritin Bio-Nanobattery." Journal of Nanotechnology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/516309.

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Nanostructured materials are increasingly important for the construction of electrochemical energy storage devices that will meet the needs of portable nanodevices. Here we describe the development of a nanoenergy storage system based on inorganic mineral phases contained in ferritin proteins. The electrochemical cell consists of an anode containing~2000 iron atoms as Fe(OH)2in the hollow protein interior of ferritin and a cathode containing~2000 of Co(OH)3in a separate ferritin molecule. The achieved initial voltage output from a combination of Fe2+- and Co3+-ferritins adsorbed on gold electr

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Zhao, Junwei, Federica Santino, Daria Giacomini, and Luca Gentilucci. "Integrin-Targeting Peptides for the Design of Functional Cell-Responsive Biomaterials." Biomedicines 8, no. 9 (2020): 307. http://dx.doi.org/10.3390/biomedicines8090307.

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Integrins are a family of cell surface receptors crucial to fundamental cellular functions such as adhesion, signaling, and viability, deeply involved in a variety of diseases, including the initiation and progression of cancer, of coronary, inflammatory, or autoimmune diseases. The natural ligands of integrins are glycoproteins expressed on the cell surface or proteins of the extracellular matrix. For this reason, short peptides or peptidomimetic sequences that reproduce the integrin-binding motives have attracted much attention as potential drugs. When challenged in clinical trials, these pe

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Hildebrand, Mark, Evelyn York, Jessica I. Kelz, et al. "Nanoscale control of silica morphology and three-dimensional structure during diatom cell wall formation." Journal of Materials Research 21, no. 10 (2006): 2689–98. http://dx.doi.org/10.1557/jmr.2006.0333.

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We present a unique approach combining biological manipulation with advanced imaging tools to examine silica cell wall synthesis in the diatom Thalassiosira pseudonana. The innate capabilities of diatoms to form complex 3D silica structures on the nano- to micro-scale exceed current synthetic approaches because they use a fundamentally different formation process. Understanding the molecular details of the process requires identifying structural intermediates and correlating their formation with genes and proteins involved. This will aid in development of approaches to controllably alter struc

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Lynch, Iseult, Ilise L. Feitshans, and Michaela Kendall. "‘Bio-nano interactions: new tools, insights and impacts’: summary of the Royal Society discussion meeting." Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1661 (2015): 20140162. http://dx.doi.org/10.1098/rstb.2014.0162.

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Bio-nano interactions can be defined as the study of interactions between nanoscale entities and biological systems such as, but not limited to, peptides, proteins, lipids, DNA and other biomolecules, cells and cellular receptors and organisms including humans. Studying bio-nano interactions is particularly useful for understanding engineered materials that have at least one dimension in the nanoscale. Such materials may consist of discrete particles or nanostructured surfaces. Much of biology functions at the nanoscale; therefore, our ability to manipulate materials such that they are taken u

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Novikov, M. A., and E. A. Titov. "Comparative Evaluation of the Expression of Apoptosis Proteins at the Influence of Metal Containing Polymeric Nanocomposites on the Brain." Acta Biomedica Scientifica 4, no. 2 (2019): 136–39. http://dx.doi.org/10.29413/abs.2019-4.2.19.

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Background. The creation and the attempt to introduce into medicine new nanostructured materials dictate the need for careful study of their safety for human health and the environment. At the same time, the existing classical approaches to safety assessment do not always objectively reflect the real state of affairs; therefore, there is a need to introduce new approaches, including methods of intracellular safety assessment of nanoparticles and nanomaterials.The aim of this study was to evaluate expression level of apoptosis-regular proteins caspase-3 and bcl-2 in neurons of white outbred rat

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Rivero, Pedro, Javier Goicoechea, and Francisco Arregui. "Layer-by-Layer Nano-assembly: A Powerful Tool for Optical Fiber Sensing Applications." Sensors 19, no. 3 (2019): 683. http://dx.doi.org/10.3390/s19030683.

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The ability to tune the composition of nanostructured thin films is a hot topic for the design of functional coatings with advanced properties for sensing applications. The control of the structure at the nanoscale level enables an improvement of intrinsic properties (optical, chemical or physical) in comparison with the traditional bulk materials. In this sense, among all the known nanofabrication techniques, the layer-by-layer (LbL) nano-assembly method is a flexible, easily-scalable and versatile approach which makes possible precise control of the coating thickness, composition and structu

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Mansurov, Z. A., A. R. Kerimkulova, S. A. Ibragimova, and E. Y. Gukenheimer. "Carbon Nanosorbent for Purification Different Biomolecules." Eurasian Chemico-Technological Journal 14, no. 1 (2011): 41. http://dx.doi.org/10.18321/ectj98.

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The article presents the results of physico-chemical studies on the development of nanostructured carbon materials from domestic raw materials. Were obtained and tested micro-mesoporous carbon sorbents for molecular-sieve chromatography of markers and investigated the applicability of carbon sorbents for the separation of protein-lipid complex, and plant bio-stimulator. Carbon sorbents have well-developed porous structure but their disadvantage is the weak mechanical<br />strength. Recently it was shown that some carbon nanostructures have enormous strength. Thus arose the need to give t

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Main, Ewan R. G., Jonathan J. Phillips, and Charlotte Millership. "Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks." Biochemical Society Transactions 41, no. 5 (2013): 1152–58. http://dx.doi.org/10.1042/bst20130102.

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There is enormous interest in molecular self-assembly and the development of biological systems to form smart nanostructures for biotechnology (so-called ‘bottom-up fabrications’). Repeat proteins are ideal choices for development of such systems as they: (i) possess a relatively simple relationship between sequence, structure and function; (ii) are modular and non-globular in structure; (iii) act as diverse scaffolds for the mediation of a diverse range of protein–protein interactions; and (iv) have been extensively studied and successfully engineered and designed. In the present review, we s

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Tetyczka, Carolin, Sonja Hartl, Ramona Jeitler, et al. "Cytokine-Mediated Inflammation in the Oral Cavity and Its Effect on Lipid Nanocarriers." Nanomaterials 11, no. 5 (2021): 1330. http://dx.doi.org/10.3390/nano11051330.

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Topical drug administration to the oral mucosa proves to be a promising treatment alternative for inflammatory diseases. However, disease-related changes in the cell barrier must be considered when developing such delivery systems. This study aimed at investigating the changes in the lining mucosa caused by inflammation and evaluating the consequences on drug delivery systems such as nanostructured lipid carriers (NLC). For this, TR146 cells were treated with inflammatory cytokines and bacterial components. Cell viability and integrity, reactive oxygen species (ROS), and interleukin (IL)-8 rel

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Axente, Emanuel, and Felix Sima. "Biomimetic Nanostructures with Compositional Gradient Grown by Combinatorial Matrix-Assisted Pulsed Laser Evaporation for Tissue Engineering." Current Medicinal Chemistry 27, no. 6 (2020): 903–18. http://dx.doi.org/10.2174/0929867326666190916145455.

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: There is permanent progress with the fabrication of smart bioactive surfaces that could govern tissue regeneration. Thin coatings of two or more materials with compositional gradient allow the construction of arrays with different chemical and physical features on a solid substrate. With such intelligent bio-platforms, cells can be exposed to a tissue-like biomimetic micro-environment with precise characteristics that directs cells fate towards specific phenotypes. : We have introduced combinatorial matrix-assisted pulsed laser evaporation (C-MAPLE) as an alternative approach for the fabrica

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Zhao, Yue, Ziyu Yao, Christopher D. Snow, et al. "Stable Fluorescence of Eu3+ Complex Nanostructures Beneath a Protein Skin for Potential Biometric Recognition." Nanomaterials 11, no. 9 (2021): 2462. http://dx.doi.org/10.3390/nano11092462.

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We designed and realized highly fluorescent nanostructures composed of Eu3+ complexes under a protein coating. The nanostructured material, confirmed by photo-induced force microscopy (PiFM), includes a bottom fluorescent layer and an upper protein layer. The bottom fluorescent layer includes Eu3+ that is coordinated by 1,10-phenanthroline (Phen) and oleic acid (O). The complete complexes (OEu3+Phen) formed higher-order structures with diameter 40–150 nm. Distinctive nanoscale striations reminiscent of fingerprints were observed with a high-resolution transmission electron microscope (HRTEM).

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Azam, Anum, and Danielle Tullman-Ercek. "Type-III secretion filaments as scaffolds for inorganic nanostructures." Journal of The Royal Society Interface 13, no. 114 (2016): 20150938. http://dx.doi.org/10.1098/rsif.2015.0938.

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Nanostructured materials exhibit unique magnetic, electrical and catalytic properties. These characteristics are determined by the chemical composition, size and shape of the nanostructured components, which are challenging to modulate on such small size scales and to interface with living cells. To address this problem, we are using a self-assembling filament protein, PrgI, as a scaffold for bottom-up inorganic nanostructure synthesis. PrgI is a small protein (80 amino acids) that oligomerizes to form the type-III secretion system needle of Salmonella enterica . We demonstrate that purified P

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Salvo-Comino, Coral, Celia García-Hernández, Cristina García-Cabezón, and Maria Rodríguez-Méndez. "Discrimination of Milks with a Multisensor System Based on Layer-by-Layer Films." Sensors 18, no. 8 (2018): 2716. http://dx.doi.org/10.3390/s18082716.

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A nanostructured electrochemical bi-sensor system for the analysis of milks has been developed using the layer-by-layer technique. The non-enzymatic sensor [CHI+IL/CuPcS]2, is a layered material containing a negative film of the anionic sulfonated copper phthalocyanine (CuPcS) acting as electrocatalytic material, and a cationic layer containing a mixture of an ionic liquid (IL) (1-butyl-3-methylimidazolium tetrafluoroborate) that enhances the conductivity, and chitosan (CHI), that facilitates the enzyme immobilization. The biosensor ([CHI+IL/CuPcS]2-GAO) results from the immobilization of gala

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Hernandez-Garcia, Armando. "Strategies to Build Hybrid Protein–DNA Nanostructures." Nanomaterials 11, no. 5 (2021): 1332. http://dx.doi.org/10.3390/nano11051332.

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Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid

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Bandić, Zvonimir Z., Dmitri Litvinov, and M. Rooks. "Nanostructured Materials in Information Storage." MRS Bulletin 33, no. 9 (2008): 831–37. http://dx.doi.org/10.1557/mrs2008.178.

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AbstractThe ever-increasing demand for information storage has pushed research and development of nonvolatile memories, particularly magnetic disk drives and silicon-based memories, to areal densities where bit sizes are approaching nanometer dimensions. At this level, material and device phenomena make further scaling increasingly difficult. The difficulties are illustrated in the examples of magnetic media and flash memory, such as thermal instability of sub-100-nm bits in magnetic memory and charge retention in flash memory, and solutions are discussed in the form of patterned media and cro

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Gomes, Conor M., and Leila F. Deravi. "Self-assembling extracellular matrix proteins as materials for the condensation of silica nanostructures." RSC Advances 6, no. 97 (2016): 95337–41. http://dx.doi.org/10.1039/c6ra20911d.

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A synthetic strategy is described to repurpose human extracellular matrix protein binding domains to catalyse the condensation of silica nanostructures in water for a seamlessly integrated biocomposite material.

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Jaekel, Stegemann, and Saccà. "Manipulating Enzymes Properties with DNA Nanostructures." Molecules 24, no. 20 (2019): 3694. http://dx.doi.org/10.3390/molecules24203694.

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Nucleic acids and proteins are two major classes of biopolymers in living systems. Whereas nucleic acids are characterized by robust molecular recognition properties, essential for the reliable storage and transmission of the genetic information, the variability of structures displayed by proteins and their adaptability to the environment make them ideal functional materials. One of the major goals of DNA nanotechnology—and indeed its initial motivation—is to bridge these two worlds in a rational fashion. Combining the predictable base-pairing rule of DNA with chemical conjugation strategies a

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Ryu, Yiseul, Cheol Am Hong, Yunjin Song, et al. "Modular protein–DNA hybrid nanostructures as a drug delivery platform." Nanoscale 12, no. 8 (2020): 4975–81. http://dx.doi.org/10.1039/c9nr08519j.

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A modular and biocompatible assembly of functional protein–DNA hybrid nanostructures through sequence-specific interactions between zinc-finger proteins and DNA was demonstrated for cytosolic drug delivery.

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Zhang, Dong, and Yi Wang. "Functional Protein-Based Bioinspired Nanomaterials: From Coupled Proteins, Synthetic Approaches, Nanostructures to Applications." International Journal of Molecular Sciences 20, no. 12 (2019): 3054. http://dx.doi.org/10.3390/ijms20123054.

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Protein-based bioinspired nanomaterials (PBNs) combines the advantage of the size, shape, and surface chemistry of nanomaterials, the morphology and functions of natural materials, and the physical and chemical properties of various proteins. Recently, there are many exciting developments on biomimetic nanomaterials using proteins for different applications including, tissue engineering, drug delivery, diagnosis and therapy, smart materials and structures, and water collection and separation. Protein-based biomaterials with high biocompatibility and biodegradability could be modified to obtain

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