Academic literature on the topic 'Nanotopographical cue'

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Journal articles on the topic "Nanotopographical cue"

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Fischer, Robert S., Xiaoyu Sun, Michelle A. Baird, et al. "Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates." Proceedings of the National Academy of Sciences 118, no. 22 (2021): e2021135118. http://dx.doi.org/10.1073/pnas.2021135118.

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Contact guidance is a powerful topographical cue that induces persistent directional cell migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix (ECM) fiber bundles, whereas metastasis-prone stroma exhibit less wavy, more linear fibers. The latter topography correlates with poor prognosis, whereas more wavy bundles correlate with benign tumors. We designed nanotopographic ECM-coated substrates that mimic collagen fibril waveforms seen in tumors and healthy tissues to determine how these nanotopographies may regulate cancer cell polarization and migration m
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Dissertations / Theses on the topic "Nanotopographical cue"

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GALLI, ALESSANDRA. "MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF THE MECHANOTRANSDUCTION SIGNALING PATHWAY IN PANCREATIC ENDOCRINE CELLS: IMPLICATIONS FOR BETA CELLS SURVIVAL, DIFFERENTIATION AND FUNCTION." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/827453.

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Le cellule β-pancreatiche svolgono un ruolo fondamentale nell’omeostasi glucidica, essendo le uniche cellule del corpo in grado di produrre e secernere insulina. Alterazioni della loro funzionalità o del loro numero determinano lo sviluppo del diabete mellito, un gruppo di patologie ad eziologia eterogenea caratterizzate da iperglicemia. L’approccio più efficace per trattare i pazienti diabetici dovrebbe consistere nel ripristinare la funzionalità o la massa β-cellulare tramite terapie rigenerative o sostitutive. Tra le terapie sostitutive particolarmente promettenti vi sono quelle che utilizz
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Kuforiji, Folashade. "The investigation of surface chemical and nanotopographical cues to engineer biointerfaces." Thesis, Keele University, 2015. http://eprints.keele.ac.uk/2351/.

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This thesis is focused on understanding the fundamental physical interaction occurring, when a material interacts with a biological fluid containing protein molecules and cells. The interaction of proteins with defined surface chemistry and nanotopography is of major interest in the field of biomaterials. Despite the degree of research undertaken to study this interface, there is still a lack of understanding of how the protein layer evolves with respect to surface parameters, and further how cells condition the surface. By understanding these processes, advanced biomaterial coatings may be de
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Pinho, Ana Rita Gonçalves. "The effect of 3D nanotopographical guidance cues on axonal outgrowth." Master's thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/90054.

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Pinho, Ana Rita Gonçalves. "The effect of 3D nanotopographical guidance cues on axonal outgrowth." Dissertação, 2013. https://repositorio-aberto.up.pt/handle/10216/90054.

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