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Journal articles on the topic 'NAPEM'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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1

Hamamoto Filho, Pedro Tadao, Vinicius Cunha Venditti, Licério Miguel, Ludmila Almeida Silva, Cristiano Claudino Oliveira, and José Carlos Peraçoli. "Pesquisa em educação médica conduzida por estudantes: um ano de experiência do núcleo acadêmico de pesquisa em educação Médica." Revista Brasileira de Educação Médica 35, no. 1 (March 2011): 108–13. http://dx.doi.org/10.1590/s0100-55022011000100015.

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A pesquisa em educação médica vem se desenvolvendo muito nos últimos anos. A participação de estudantes nos processos de mudanças curriculares também é crescente e bastante contributiva. Ainda, a iniciação científica está sendo amplamente defendida por seu impacto positivo na formação profissional. Relatamos um ano de experiência do Núcleo Acadêmico de Pesquisa em Educação Médica (Napem), que integra as propostas de participação discente nas discussões de ensino médico através de trabalhos de iniciação científica em educação médica. O Napem foi fundado em 2008 e foi bem aceito na comunidade acadêmica da Faculdade de Medicina de Botucatu/Universidade Estadual Paulista (FMB/Unesp). Seus projetos de pesquisa atuais investigam: avaliação do curso médico, avaliação do estudante, fatores que influenciam a busca por iniciação científica, Ligas Acadêmicas e interdisciplinaridade. Estão envolvidos 17 estudantes e dez professores. Em um ano, o Napem apresentou trabalhos em congressos, publicou artigo em periódico indexado e está certificado como grupo de pesquisa no CNPq. Dentre seus desafios estão a necessidade de contínua renovação dos estudantes e o avanço nas pesquisas, de modo que os projetos não se encerrem em si mesmos, mas constituam um continuum de investigação à medida que novas informações sejam agregadas ao conhecimento.
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2

OKAMOTO, Yasuo, Jun MORISHITA, Jun WANG, Patricia C. SCHMID, Randy J. KREBSBACH, Harald H. O. SCHMID, and Natsuo UEDA. "Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolysing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines." Biochemical Journal 389, no. 1 (June 21, 2005): 241–47. http://dx.doi.org/10.1042/bj20041790.

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In animal tissues, NAEs (N-acylethanolamines), including N-arachidonoylethanolamine (anandamide), are primarily formed from their corresponding NAPEs (N-acylphosphatidylethanolamines) by a phosphodiesterase of the PLD (phospholipase D) type (NAPE-PLD). Recently, we cloned cDNAs of NAPE-PLD from mouse, rat and human [Okamoto, Morishita, Tsuboi, Tonai and Ueda (2004) J. Biol. Chem. 279, 5298–5305]. However, it remained unclear whether NAPE-PLD acts on endogenous NAPEs contained in the membrane of living cells. To address this question, we stably transfected two mammalian cell lines (HEK-293 and CHO-K1) with mouse NAPE-PLD cDNA, and investigated the endogenous levels and compositions of NAPEs and NAEs in these cells, compared with mock-transfected cells, with the aid of GC-MS. The overexpression of NAPE-PLD caused a decrease in the total amount of NAPEs by 50–90% with a 1.5-fold increase in the total amount of NAEs, suggesting that the recombinant NAPE-PLD utilizes endogenous NAPE as a substrate in the cell. Since the compositions of NAEs and NAPEs of NAPE-PLD-overexpressing cells and mock-transfected cells were very similar, the enzyme did not appear to discriminate among the N-acyl groups of endogenous NAPEs. These results confirm that overexpressed NAPE-PLD is capable of forming NAEs, including anandamide, in living cells.
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3

Castellani, Beatrice, Eleonora Diamanti, Daniela Pizzirani, Piero Tardia, Martina Maccesi, Natalia Realini, Paola Magotti, et al. "Synthesis and characterization of the first inhibitor ofN-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)." Chemical Communications 53, no. 95 (2017): 12814–17. http://dx.doi.org/10.1039/c7cc07582k.

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4

Ribeiro, Maria Mônica Freitas, Jordan Diego Costa Melo, and Andreia Maria Camargos Rocha. "Avaliação da Demanda Preliminar de Atendimento Dirigida pelo Aluno ao Núcleo de Apoio Psicopedagógico ao Estudante da Faculdade de Medicina (Napem) da Universidade Federal de Minas Gerais." Revista Brasileira de Educação Médica 43, no. 1 suppl 1 (2019): 91–97. http://dx.doi.org/10.1590/1981-5271v43suplemento1-20190042.

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RESUMO O sofrimento psíquico do estudante universitário, particularmente do estudante de Medicina, é conhecido e tem sido motivo de preocupação. O Núcleo de Apoio Psicopedagógico ao Estudante da Faculdade de Medicina (Napem) da Universidade Federal de Minas Gerais tem como função acolher o estudante que demanda ajuda espontaneamente. O objetivo deste trabalho foi analisar os motivos da busca por atendimento descritos pelos próprios estudantes ao preencherem a ficha de inscrição no Napem. Foram catalogadas 273 fichas, que representam o total de inscrições de novos estudantes em dois anos da última década. Para preservar a identidade dos estudantes, os anos analisados não foram identificados. Desse grupo, 235 eram estudantes de Medicina, 28 de Fonoaudiologia, 4 do curso superior de Tecnologia em Radiologia e 6 eram estudantes de outros cursos. A metodologia utilizada para análise dos dados foi qualitativa, com análise de conteúdo, e o teste do qui-quadrado foi empregado para a comparação de frequências. Os motivos descritos pelos estudantes foram alocados em cinco categorias estabelecidas pelos pesquisadores – distúrbios do humor, problemas pessoais, características de personalidade, questões acadêmicas e outros. Os resultados mostraram que os distúrbios do humor foram os mais frequentemente relatados (44,3%), seguidos por características de personalidade (26,4%) e por problemas pessoais (13,9%). As questões acadêmicas foram as que apresentaram menor frequência (5,5%). O desejo de morrer foi descrito por 17 (6,2%) estudantes. Quando os estudantes de Medicina foram comparados aos dos demais cursos, não foi observada diferença estatisticamente significativa entre as categorias (p = 0,21), sendo também observado o predomínio de motivos alocados na categoria distúrbios do humor (41,7%). Entretanto, quando considerados separadamente os dois períodos analisados, a frequência de distúrbios do humor nos alunos do curso de Medicina foi significativamente maior (p = 0,0005) entre os inscritos no segundo ano, comparados aos inscritos no primeiro ano do estudo. Deve ser ressaltado, ainda, que quase 50% do total de estudantes que se inscreveu no segundo ano analisado neste estudo cursavam os períodos iniciais, resultado significativamente maior (p = 0,002) quando comparado ao dos inscritos no primeiro ano do estudo. Embora reconhecendo as limitações referentes à análise da demanda preliminar de atendimento formulada pelo aluno ao procurar ajuda, particularmente quando expressa de forma escrita, acredita-se que os resultados deste estudo possam contribuir para a organização dos serviços de apoio psíquico e servir de alerta para essa questão. Pela magnitude do problema, fica evidente a necessidade da existência de espaços de acolhimento para os estudantes e de atuação precoce no início do curso, com atividades que possam recebê-los e escutá-los quando do ingresso na faculdade, como, por exemplo, os programas de tutoria.
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Rastogi, Sanjeev, Ranjana Rastogi, Devesh Rastogi, Rajiv Rastogi, Girish Singh, and Francesco Chiappelli. "Evaluating the Impact of a Pragmatic Nutrition Awareness Program for Expectant Mothers upon Birth Weight of the Newborn." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–7. http://dx.doi.org/10.1093/ecam/neq034.

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Poor maternal nutritional status and substandard antenatal care, which result in increased women's risk, low birth weight and stillbirth, afflict many countries with weak or emerging economies even today. Studies that address the effect of extending nutrition awareness among pregnant women to the net outcome of pregnancy remain scarce. We aimed to compare and contrast the effect of a pragmatic nutrition awareness program for expectant mothers (NAPEM) on birth weight of the newborn with a control group who received no such nutrition awareness activity. The effect of variables of mode of newborn delivery, associated complications at birth, and APGAR score of the newborn were also assessed. A pragmatic intervention trial of an antenatal care (ANC) program that consisted in nutrition awareness was conducted involving 53 pregnant women. Awareness was given through one-to-one interview and through informational literature provided to the participants in the local language. A hospital registry for deliveries undertaken during the study period was screened for identification of variables. A control group of matched pregnant women (n= 53) was obtained from the same hospital registry from preceding years, when the nutrition awareness program was not executed. A statistically significant improvement in birth weight of the newborn was observed in the intervention group, where expectant mothers were made aware about desired nutrition during pregnancy. A reduced incidence of complications associated with pregnancy was also observed in the intervention group. Providing awareness about nutritional requirements during pregnancy and suggesting the pragmatic ways to meet them was shown to be one possible effective measure to deal with pregnancy-related undernutrition. We show the efficacy of the intervention for underprivileged regions of India marked by inadequate health care delivery and lower socio-economical standards. We discuss our findings in the context of available evidence-based guidelines.
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6

PRAG, JONATHAN R. W. "CAVE NAVEM." Classical Quarterly 56, no. 2 (December 2006): 538–47. http://dx.doi.org/10.1017/s0009838806000528.

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7

Watts, Geoff. "Naeem Aon Jafarey." Lancet 387, no. 10013 (January 2016): 24. http://dx.doi.org/10.1016/s0140-6736(15)01304-5.

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8

Aggarwal, Geetika, Jonah E. Zarrow, Zahra Mashhadi, C. Robb Flynn, Paige Vinson, C. David Weaver, and Sean S. Davies. "Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D." Journal of Biological Chemistry 295, no. 21 (April 13, 2020): 7289–300. http://dx.doi.org/10.1074/jbc.ra120.013362.

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N-Acyl-phosphatidylethanolamine phospholipase D (NAPE-PLD) (EC 3.1.4.4) catalyzes the final step in the biosynthesis of N-acyl-ethanolamides. Reduced NAPE-PLD expression and activity may contribute to obesity and inflammation, but a lack of effective NAPE-PLD inhibitors has been a major obstacle to elucidating the role of NAPE-PLD and N-acyl-ethanolamide biosynthesis in these processes. The endogenous bile acid lithocholic acid (LCA) inhibits NAPE-PLD activity (with an IC50 of 68 μm), but LCA is also a highly potent ligand for TGR5 (EC50 0.52 μm). Recently, the first selective small-molecule inhibitor of NAPE-PLD, ARN19874, has been reported (having an IC50 of 34 μm). To identify more potent inhibitors of NAPE-PLD, here we used a quenched fluorescent NAPE analog, PED-A1, as a substrate for recombinant mouse Nape-pld to screen a panel of bile acids and a library of experimental compounds (the Spectrum Collection). Muricholic acids and several other bile acids inhibited Nape-pld with potency similar to that of LCA. We identified 14 potent Nape-pld inhibitors in the Spectrum Collection, with the two most potent (IC50 = ∼2 μm) being symmetrically substituted dichlorophenes, i.e. hexachlorophene and bithionol. Structure–activity relationship assays using additional substituted dichlorophenes identified key moieties needed for Nape-pld inhibition. Both hexachlorophene and bithionol exhibited significant selectivity for Nape-pld compared with nontarget lipase activities such as Streptomyces chromofuscus PLD or serum lipase. Both also effectively inhibited NAPE-PLD activity in cultured HEK293 cells. We conclude that symmetrically substituted dichlorophenes potently inhibit NAPE-PLD in cultured cells and have significant selectivity for NAPE-PLD versus other tissue-associated lipases.
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9

Marek, Petr, and Jana Skálová. "Daně v našem životě." Český finanční a účetní časopis 2009, no. 1 (March 1, 2009): 4–5. http://dx.doi.org/10.18267/j.cfuc.15.

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10

Malatesta, Julián. "Cartas a Farim Nasem." La Manzana de la Discordia 7, no. 1 (March 18, 2016): 112. http://dx.doi.org/10.25100/lamanzanadeladiscordia.v7i1.1579.

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Cartas a Farim NasemPoemario por Ángela Tello GonzálezColección Las OfrendasEscuela de Estudios LiterariosFacultad de Humanidades, Universidad del ValleSantiago de Cali, septiembre de 2011ISBN: 978-958-670-917-0
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Malatesta, Julián. "Cartas a Farim Nasem." La Manzana de la Discordia 7, no. 1 (March 18, 2016): 112. http://dx.doi.org/10.25100/lmd.v7i1.1579.

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12

Fadzlina, Z. A. Noor, T. T. Teng, and M. Abdul Rahman. "Measurement and Prediction of Densities of Ternary Aqueous Mixtures Involving Sodium Polyacrylate." ASEAN Journal of Chemical Engineering 4, no. 1 (December 1, 2004): 64. http://dx.doi.org/10.22146/ajche.50851.

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The densities of the binary aqueous solutions of sodium polyacrylate (NaPM) at 20°C, 25°C, and 300C up to 0.17 m and LiCI at 25°C and 300C up to 3.13 m were measured using a vibrating tube digital densitimeter. The measured experimental data were then fitted to the polynomial d = do + IA;m'. The densities of the ternary aqueous systems NaPM-NaCI, NaPM-LiCI, and NaPM-sucrose were also =1 measured from 20°C to 30°C. The isopycnotic equation, Imi / moi was used to predict the densities of the ternary aqueous systems mentioned. The results show that predicted and observed density values are in good agreement. The overall percentage error of density prediction for the system NaPM-NaCI-H20 is 0.067. For the system NaPM-LiCI-HP,the overall percentage error is 0.074; and, for the system NaPM-sucrose-H20, the overall percentage error is 0.065.
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13

Nkpoyen, Festus, Esther P. Archibong, Veronica Undelikwo, Ude Bassey Obeten, and Nnana Okoi Ofem. "Social welfare program and poverty eradication in sub-saharan region of Eket Senatorial district, Akwa Ibom State, Nigeria." Revista Amazonia Investiga 10, no. 42 (July 31, 2021): 163–75. http://dx.doi.org/10.34069/ai/2021.42.06.15.

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The study investigated development gap in social policy and social problem interaction by examining impact of National Poverty Eradication Programme (NAPEP) on rural communities in Akwa Ibom State, Nigeria. The specific objectives were to examine the relationship between non-participation of beneficiary communities in NAPEP project design at community level, corruption and policy implementation strategy on rural poverty reduction. The Ex-post facto research design was adopted to study communities in Oron and Udung Uko local government areas in Akwa Ibom State. Using a multistage sampling procedure, data were obtained from 400 respondents using Taro Yamene sample size determination formula. Data were analysed using Chi-square (X2) statistical technique. Main findings indicated that significant relationship exists between non-participation of beneficiary communities in NAPEP project design, corruption, policy implementation and poverty reduction in rural communities. The findings imply that NAPEP has not significantly achieved its goal of poverty reduction in rural communities. It has failed to elicit economic wellbeing priorities directly from target communities. Poverty can be reduced through accommodative and humanistic arrangements by allowing communities to identify welfare projects and eligible recipients. Rural dwellers have not experienced poverty reduction because of NAPEP development strategy gap.
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Chen, Zhongyi, Yongqin Zhang, Lilu Guo, Noura Dosoky, Lorenzo de Ferra, Scott Peters, Kevin D. Niswender, and Sean S. Davies. "Leptogenic effects of NAPE require activity of NAPE-hydrolyzing phospholipase D." Journal of Lipid Research 58, no. 8 (June 8, 2017): 1624–35. http://dx.doi.org/10.1194/jlr.m076513.

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15

Lefort, Charlotte, Martin Roumain, Matthias Van Hul, Marialetizia Rastelli, Rita Manco, Isabelle Leclercq, Nathalie M. Delzenne, et al. "Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism." Cells 9, no. 5 (May 18, 2020): 1247. http://dx.doi.org/10.3390/cells9051247.

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Diverse metabolic disorders have been associated with an alteration of N-acylethanolamine (NAE) levels. These bioactive lipids are synthesized mainly by N-acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD) and influence host metabolism. We have previously discovered that NAPE-PLD in the intestine and adipose tissue is connected to the pathophysiology of obesity. However, the physiological function of NAPE-PLD in the liver remains to be deciphered. To study the role of liver NAPE-PLD on metabolism, we generated a new mouse model of inducible Napepld hepatocyte-specific deletion (Napepld∆Hep mice). In this study, we report that Napepld∆Hep mice develop a high-fat diet-like phenotype, characterized by an increased fat mass gain, hepatic steatosis and we show that Napepld∆Hep mice are more sensitive to liver inflammation. We also demonstrate that the role of liver NAPE-PLD goes beyond the mere synthesis of NAEs, since the deletion of NAPE-PLD is associated with a marked modification of various bioactive lipids involved in host homeostasis such as oxysterols and bile acids. Collectively these data suggest that NAPE-PLD in hepatocytes is a key regulator of liver bioactive lipid synthesis and a dysregulation of this enzyme leads to metabolic complications. Therefore, deepening our understanding of the regulation of NAPE-PLD could be crucial to tackle obesity and related comorbidities.
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Sitek, Bronisław. "Najem mieszkań w czasach Plauta." Prawo Kanoniczne 37, no. 1-2 (June 15, 1994): 181–88. http://dx.doi.org/10.21697/pk.1994.37.1-2.06.

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Il fenomeno dell’affitto delle case a Roma risale al III secolo a. C. La più remota menzione proviene dal Plauto. Pur usando la lingua quotidiana, compresibile per i ascoltatori, le sue testi sono preziossisimi fonti da punto di vista giuridicostorico. Di qui sappiamo, che l’affïtto delle case si nasce nel periodo dei grandi transformazioni sociali, politici e demografici. Dal suo inizio e un contratto consensuale. Pero il grande svillippo dell’affitto delle case si incomincia dal I secolo a. C. e poi. D’allora, con questa istituzione non si impeniava soltanto il pretore ma sopratutto i prudentes.
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Howell, Emily L., Christopher D. Wirz, Dominique Brossard, Kathleen Hall Jamieson, Dietram A. Scheufele, Kenneth M. Winneg, and Michael A. Xenos. "National Academies of Sciences, Engineering, and Medicine report on genetically engineered crops influences public discourse." Politics and the Life Sciences 37, no. 2 (2018): 250–61. http://dx.doi.org/10.1017/pls.2018.12.

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In May 2016, the National Academies of Sciences, Engineering, and Medicine (NASEM) released the report “Genetically Engineered Crops: Experiences and Prospects,” summarizing scientific consensus on genetically engineered crops and their implications. NASEM reports aim to give the public and policymakers information on socially relevant science issues. Their impact, however, is not well understood. This analysis combines national pre- and post-report survey data with a large-scale content analysis of Twitter discussion to examine the report’s effect on public perceptions of genetically modified organisms (GMOs). We find that the report’s release corresponded with reduced negativity in Twitter discourse and increased ambivalence in public risk and benefit perceptions of GMOs, mirroring the NASEM report’s conclusions. Surprisingly, this change was most likely for individuals least trusting of scientific studies or university scientists. Our findings indicate that NASEM consensus reports can help shape public discourse, even in, or perhaps because of, the complex information landscape of traditional and social media.
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Chizzotti, Mario Luiz, Sebastião de Campos Valadares Filho, Pedro Del Bianco Benedeti, and Flávia Adriane de Sales Silva. "California net energy system for Bos taurus indicus." Translational Animal Science 3, no. 3 (June 1, 2019): 991–98. http://dx.doi.org/10.1093/tas/txz016.

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Abstract The California net energy system (CNES) was the reference for the development of most energy requirement systems worldwide, such as Nutrient Requirements of Beef Cattle (NASEM, Nutrient requirements of beef cattle, 8th Revised ed, 2016) and Brazilian Nutrient Requirements of Zebu and Crossbred Cattle (Valadares Filho, S. C., L. F. C. Silva, M. P. Gionbelli, P. P. Rotta, M. I. Marcondes, M. L. Chizzotti, and L. F. Prados, BR-CORTE: nutrient requirements of zebu and crossbred cattle, 3rd ed, 2016). This review aimed to compare methods used by NASEM and BR-CORTE to estimate the energy requirements for beef cattle. The net energy requirements for maintenance (NEm) of BR-CORTE is based on empty body weight (EBW), whereas NASEM uses shrunk body weight (SBW), but the Bos taurus indicus presents 10% to 8% lower NEm than Bos taurus taurus. We have compared animals with different EBW and SBW but with same equivalent empty body weight/standard reference weight ratio (0.75), as both systems have suggested different mature weights. Both systems predicted similar net energy requirements for gain (NEg) for animals with 1.8 kg of daily gain. However, estimated empty body gain was lower for NASEM estimations when the same metabolizable energy for gain is available. For pregnancy and lactation of beef cows, the NEm and net energy requirements for pregnancy (NEp) of a Zebu cow estimated by BR-CORTE were lower than the values estimated by NASEM. Furthermore, the magnitude of differences between these systems regarding NEp increased as pregnancy days increase. The NASEM and BR-CORTE systems have presented similar values for energy requirement for lactation (0.72 and 0.75 Mcal/kg milk, respectively).
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Kluzek, Marta. "LEASE AS A SOURCE OF TAXATION OF INDIVIDUALS." Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, no. 481 (2017): 23–32. http://dx.doi.org/10.15611/pn.2017.481.02.

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20

S. Kadu, Nilesh. "STRUCTURE-ACTIVITY RELATIONSHIP: STUDY OF LEI-401 AS INHIBITOR OF NAPE-PLD BY PHARMACOPHORE MODEL." International Journal of Advanced Research 9, no. 5 (May 31, 2021): 662–66. http://dx.doi.org/10.21474/ijar01/12889.

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N-acyl-phosphatidylethanolamine phospholipase D (NAPE–PLD) is considered to be the principal enzyme that produces N-acylethanolamines (NAEs), a family of signaling lipids. NAEs are involved in numerous physiological processes such as appetite, satiety, pain, inflammation, fertility, stress, and anxiety. Furthermore, aberrant NAE levels are associated with metabolic syndrome and non-alcoholic steatohepatitis (NASH). Several inhibitors for NAPE–PLD have been reported. But most of the inhibitors showed poor to moderate potency for NAPE–PLD in vitro. Recently, Mario van der Stelt et al describe the SAR of NAPE–PLD inhibitors that afforded LEI–401 in vitro. However, no attempt was instigated to produce a consensus pharmacophore model of LEI–401 as inhibitors of NAPE–PLD. Pharmacophore modeling is an efficient and useful approach to identify important patterns in a series of molecules for optimizations. The consensus pharmacophore model revealed the importance of structural features and their correlation with the biological activity.
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Lee, Yu-Min, Kuan-Te Pan, and Chun Chen. "NaPer: A TSV Noise-Aware Placer." IEEE Transactions on Very Large Scale Integration (VLSI) Systems 25, no. 5 (May 2017): 1703–13. http://dx.doi.org/10.1109/tvlsi.2016.2645230.

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Mladenovski, Sergej. "Neki aspekti eksheredacije u našem pravu." Glasnik Advokatske komore Vojvodine 65, no. 9-10 (1993): 13–15. http://dx.doi.org/10.5937/gakv9304013m.

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23

Shae. "The Nape of My Neck." Dialogue: A Journal of Mormon Thought 53, no. 1 (2020): 184. http://dx.doi.org/10.5406/dialjmormthou.53.1.0184.

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Bonkevitch, F., and P. R. M. Souza. "Nape keloid folicullitis and pruritus." Medical Hypotheses 82, no. 4 (April 2014): 502. http://dx.doi.org/10.1016/j.mehy.2014.01.012.

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Goldman, Boris E., and David M. Goldenberg. "Nape of Neck Eyebrow Reconstruction." Plastic and Reconstructive Surgery 111, no. 3 (March 2003): 1217–20. http://dx.doi.org/10.1097/01.prs.0000047532.52502.6c.

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Xiao-yin, Hua. "Clinical application of nape acupuncture." Journal of Acupuncture and Tuina Science 1, no. 2 (April 2003): 39. http://dx.doi.org/10.1007/bf02850950.

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Melford, Sarah E., Anthony H. Taylor, and Justin C. Konje. "Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLD in vitro." Reproduction and Fertility 2, no. 2 (April 21, 2021): 107–16. http://dx.doi.org/10.1530/raf-20-0035.

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Objective To determine if models of human 'receptive' and 'non-receptive endometrium' differ in their responses to nitric oxide (NO) supplementation by measuring the levels of the enzymes of the endocannabinoid system (ECS) (fatty acid amide hydrolase (FAAH) and N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD)), which control the 'anandamide tone' essential for successful pregnancy. Design A study of FAAH and NAPE-PLD expression (using human endometrium) through the menstrual cycle and an in vitro using a model of 'receptive' (Ishikawa) and 'non-receptive' (HEC-1A) human endometrial cell lines treated with the NO-donating compound S-nitroso-N-acetylpenicillamine (SNAP). Results Immunoreactivity measured by optimised H-score for both FAAH and NAPE-PLD was reduced in secretory (receptive) endometrium compared to proliferative (non-receptive) endometrium (P = 0.0009 and <0.0001, respectively). FAAH and NAPE transcript levels were significantly higher in untreated Ishikawa cells than in HEC-1A cells (P = 0.0228 and 0.0001, respectively). Treatment of cultures with SNAP resulted in an increase in the amount of FAAH mRNA produced by Ishikawa cells and a decrease in NAPE-PLD mRNA. No effect of SNAP was observed in HEC-1A cells. Similarly, FAAH protein was significantly decreased in endometria representative of the receptive endometrium. Conclusion These data suggest that NO most likely affects the expression of ECS enzymes in the implantation site of a receptive endometrium; a phenomenon not seen in a non-receptive endometrium. These effects are most marked with FAAH expression, suggesting that FAAH may play the more critical role in ensuring the correct 'anandamide tone' for successful embryo implantation than NAPE-PLD. Lay summary Embryo implantation into the wall of the uterus is only successful when the inner wall of the uterus (the endometrium) is ‘receptive’, because if it is ‘non-receptive’, implantation will fail. Previous work showed that enzymes of the 'endocannabinoid system' are critical for implantation by maintaining the correct level of a fat called anandamide. This is by balancing its synthesis (by N-acylphosphatidylethanolamine specific phospholipase D, NAPE-PLD) and degradation (by fatty acid amide hydrolase, FAAH). Using immortalised cell lines as models of ‘receptive’ and ‘non-receptive’ human endometrium, we demonstrate a key stimulator of implantation, nitric oxide, has a positive effect on implantation by both increasing the mRNA levels of the degrading enzyme (FAAH) and decreasing the expression of the synthesising enzyme (NAPE-PLD). These effects are most marked with the degrading enzyme, suggesting that FAAH plays a more critical role than NAPE-PLD in ensuring the correct 'anandamide tone' for successful embryo implantation.
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Hunger, Cláudio. "Mobilizar o mundo: O povo da mercadoria partindo das perspectivas de Bruno Latour e Davi Kopenawa Yanomami." Língua-lugar : Literatura, História, Estudos Culturais 1, no. 2 (February 26, 2021): 78–91. http://dx.doi.org/10.34913/journals/lingualugar.2020.e420.

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A queda do céu apresenta uma sociedade ocidental cujos membros são prisioneiros de uma paixão obsessiva pelos objetos. Os brancos, ou usando a palavra yanomami, os napë, sonham, segundo Davi Kopenawa Yanomami, com objetos e acumulam-nos, nem que seja para tê-los armazenados em casa. A visão sobre os napë, que Kopenawa desenvolve no seu livro, propõe uma sociedade ocidental caraterizada por uma relação patológica com os objetos. Esta proposta, expressa na denominação povo da mercadoria, dialoga com a perspectiva de Bruno Latour, segundo a qual os objetos são de primordial importância para a constituição da sociedade ocidental. Com o presente ensaio, que se baseia nos dois pensadores acima mencionados, procuro atingir três objetivos. Primeiro: dar uma ideia da ameaça que o Ocidente representa para os yanomami. Segundo: mostrar que esta ameaça se deve antes de mais à relação que o Ocidente mantém com os objetos. Terceiro: assinalar que A queda do céu se debruça tanto sobre os yanomami quanto sobre os napë.
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Maharjan, R. K. "(P2-30) Development of Disaster and Emergency Medicine in Nepal." Prehospital and Disaster Medicine 26, S1 (May 2011): s145. http://dx.doi.org/10.1017/s1049023x11004742.

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Nepal, a landlocked country between China and India, is developing disaster and emergency medicine. In 2007, the Nepal Disaster and Emergency Medicine (NADEM) Center was formed with the aim of developing this specialty in Nepal. The first hospital was built in July 1889. It wasn't until 1988 that a Disaster Response Team was organized following a stampede incident in the national stadium in Kathmandu. The country often experiences disaster and emergency situations due to geographic and natural hazards and political tensions.In 1984, the Institute of Medicine, Tribhuvan University Teaching Hospital created emergency services with general practitioners (GPs) directing and providing services. Since then, almost all emergency services of different hospitals are run by GPs with house officers, nurses, and paramedics. There still is a lack of training and proper management, and limited equipment and infrastructure to provide needed disaster and emergency services to the people. The NADEM Center is developing coordination objectives between different emergency service providers to organize ways of service providing. This will be done through NADEM's continuing medical education and publication of Journal of Nepal Disaster and Emergency Medicine (J-NADEM) and NewsHealth; coordination among emergency medical services (prehospital), in-hospital services, and disaster and critical care medicine; and planning and implementation of different research, training, workshops, seminars, and conferences in disaster and emergency medicine with cooperation from the world. The NADEM Center will develop International Institute of Disaster and Emergency Medicine.
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Crilly, Charlotte. "Naeem v Secretary of State for Justice." Oxford Journal of Law and Religion 5, no. 3 (August 25, 2016): 640–41. http://dx.doi.org/10.1093/ojlr/rww034.

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31

MacDuffee Metzger, Megan, and Joshua A. Tucker. "Social Media and EuroMaidan: A Review Essay." Slavic Review 76, no. 1 (2017): 169–91. http://dx.doi.org/10.1017/slr.2017.16.

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As more than a billion people had done previously, on November 21, 2013, Ukrainian journalist and activist Mustafa Nayem wrote a Facebook post; this post, however, would have a much larger impact on subsequent political developments than most that had preceded it. Frustrated with President Viktor Yanukovych’s decision not to sign a long-promised association agreement with the European Union, Nayem asked others who shared his frustration to comment on his post. Even more importantly, Nayem wrote that if the post received at least 1000 comments from people willing to join him, they should all go to Independence Square to protest. And indeed they did: starting with just a few thousand people, the protests would swell to be the largest since Ukraine’s independence, particularly after police used force against protesters at the end of November 2013. Eventually, these protests led to the resignation of the government, the exile of the former president, and indirectly to the secession of Crimea and the ongoing conflict in the eastern part of the country.
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Margheritis, Eleonora, Beatrice Castellani, Paola Magotti, Sara Peruzzi, Elisa Romeo, Francesca Natali, Serena Mostarda, Antimo Gioiello, Daniele Piomelli, and Gianpiero Garau. "Bile Acid Recognition by NAPE-PLD." ACS Chemical Biology 11, no. 10 (September 12, 2016): 2908–14. http://dx.doi.org/10.1021/acschembio.6b00624.

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Raedels, Alan. "Forecasting the NAPM Purchasing Managers' Index." Journal of Purchasing and Materials Management 26, no. 4 (September 1990): 34–39. http://dx.doi.org/10.1111/j.1745-493x.1990.tb00519.x.

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Coulon, Denis, and Corinne Buré. "Acylphosphatidylglycerol (acyl-PG) orN-acylphosphatidylethanolamine (NAPE)?" Journal of Mass Spectrometry 50, no. 11 (October 13, 2015): 1318–20. http://dx.doi.org/10.1002/jms.3701.

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35

Gilmer, Allen. "NAPE Summit just around the corner." Leading Edge 36, no. 2 (February 2017): 181. http://dx.doi.org/10.1190/tle36020181.1.

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36

Guo, Yiman, Toru Uyama, S. M. Khaledur Rahman, Mohammad Mamun Sikder, Zahir Hussain, Kazuhito Tsuboi, Minoru Miyake, and Natsuo Ueda. "Involvement of the γ Isoform of cPLA2 in the Biosynthesis of Bioactive N-Acylethanolamines." Molecules 26, no. 17 (August 27, 2021): 5213. http://dx.doi.org/10.3390/molecules26175213.

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Arachidonylethanolamide (anandamide) acts as an endogenous ligand of cannabinoid receptors, while other N-acylethanolamines (NAEs), such as palmitylethanolamide and oleylethanolamide, show analgesic, anti-inflammatory, and appetite-suppressing effects through other receptors. In mammalian tissues, NAEs, including anandamide, are produced from glycerophospholipid via N-acyl-phosphatidylethanolamine (NAPE). The ɛ isoform of cytosolic phospholipase A2 (cPLA2) functions as an N-acyltransferase to form NAPE. Since the cPLA2 family consists of six isoforms (α, β, γ, δ, ɛ, and ζ), the present study investigated a possible involvement of isoforms other than ɛ in the NAE biosynthesis. Firstly, when the cells overexpressing one of the cPLA2 isoforms were labeled with [14C]ethanolamine, the increase in the production of [14C]NAPE was observed only with the ɛ-expressing cells. Secondly, when the cells co-expressing ɛ and one of the other isoforms were analyzed, the increase in [14C]N-acyl-lysophosphatidylethanolamine (lysoNAPE) and [14C]NAE was seen with the combination of ɛ and γ isoforms. Furthermore, the purified cPLA2γ hydrolyzed not only NAPE to lysoNAPE, but also lysoNAPE to glycerophospho-N-acylethanolamine (GP-NAE). Thus, the produced GP-NAE was further hydrolyzed to NAE by glycerophosphodiesterase 1. These results suggested that cPLA2γ is involved in the biosynthesis of NAE by its phospholipase A1/A2 and lysophospholipase activities.
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Gordon, Sharona E. "Excluding scientist survivors from the NASEM Action Collaborative is a step backward in changing culture to prevent sexual harassment." Journal of General Physiology 151, no. 7 (May 29, 2019): 871–73. http://dx.doi.org/10.1085/jgp.201912393.

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38

Spajić, Bojana. "Compensation for material damages in Serbian industrial property law." Glasnik Advokatske komore Vojvodine 93, no. 2 (2021): 357–76. http://dx.doi.org/10.5937/gakv93-29064.

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In the era of the digital revolution and the global market economy, the economic interests of holders of industrial property rights face threats from new and advanced forms of infringement. In order to guarantee the safeguarding of the material status of the rightsholders, standards of protection have been set at the international level as well as within the European Union - with harmonization expected to take place on a global scale. These standards, related to compensation for material damages due to the infringement on industrial property rights, largely deviate from the general rules on compensation for damages. The reason for the deviations lie in the specifics of the authorizations that are inherent to these rights and the intangible nature of the intellectual property that is the subject of the protection: hence the need for specific methods devised to calculate the compensation of damages caused by the infringement on industrial property rights. This paper analyses special rules on compensation for material damages caused by infringement on industrial property rights, observed in domestic law as it has developed from 1995 and onwards. The subject of the analysis are the relics of previous positive law, i.e., triple compensation, and compensation for up to three times the amount of the license fee, as well as the current regulations on the damages set as a lump sum compensation, under which it may not be less than the compensation for the legal use of the subject of protection and compensation equal to the tortfeasor's gains. The aim of this paper is to propose de lege ferenda norms for enhanced regulation of the matter of compensation for material damages in the field of industrial property.
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Kruger, Daniel J., Jessica S. Kruger, and R. Lorraine Collins. "Cannabis Enthusiasts’ Knowledge of Medical Treatment Effectiveness and Increased Risks From Cannabis Use." American Journal of Health Promotion 34, no. 4 (January 9, 2020): 436–39. http://dx.doi.org/10.1177/0890117119899218.

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Purpose: To compare cannabis enthusiasts’ knowledge about cannabis risks and effectiveness in treating medical conditions with existing empirical evidence. Design: A brief survey assessed cannabis use, information sources, and knowledge about risks and effectiveness. Setting: A cannabis advocacy event in April 2019 in a state with legal medical and recreational cannabis. Participants: Demographically diverse adults (N = 472) who frequently used cannabis; 85% used cannabis for health or medical purposes. Measures: Participants reported the sources of their cannabis information, health conditions they thought cannabis was effective in treating (n = 10), and health risks increased by cannabis (n = 6). Conditions and risks were based on ratings of evidence (ie, from substantial to insufficient) for therapeutic effects and risks identified in a review by The National Academies of Sciences, Engineering, and Medicine (NASEM, 2017). Analyses: Chi-square tests examined the correspondence between participants’ knowledge and NASEM conclusions. Results: Most participants’ (95% confidence interval [CI]: 74%-81%) knowledge of cannabis was from their own experiences; 18% (95% CI: 14%-21%) received information from primary care providers. On average, participants’ beliefs matched NASEM conclusions for half of effectiveness (95% CI: 50%-53%) and risk items (95% CI: 55%-57%). Many (95% CI: 38%-42%) thought that cannabis use did not increase any risk. Contrary to NASEM conclusions, many thought cannabis was effective in treating cancer (76%), depressive symptoms (72%), and epilepsy (68%). Those who received cannabis information from their primary care providers had better knowledge of medical effectiveness. Medicinal cannabis use frequency inversely predicted knowledge of medical effectiveness and increased risks of adverse events. Conclusion: There were considerable discrepancies between cannabis users’ knowledge and available evidence, highlighting the need for more research and education (by physicians, caregivers, and dispensaries) on effectiveness and health risks, especially for users with specific health issues such as pregnant women and people with depression.
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Gross, Megan A., Claire Andresen, Amanda Holder, Alexi Moehlenpah, Carla Goad, Harvey C. Freetly, Paul A. Beck, Eric A. DeVuyst, and David L. Lalman. "127 Predicting Dry Matter Intake of Gestating and Lactating Beef Cows." Journal of Animal Science 98, Supplement_2 (November 1, 2020): 58. http://dx.doi.org/10.1093/jas/skz397.132.

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Abstract In 1996, the NASEM beef cattle committee developed and published an equation to estimate cow feed intake using results from studies conducted or published between 1979 and 1993 (Nutrient Requirements of Beef Cattle). The same equation was recommended for use in the most recent version of this publication (2016). The equation is sensitive to cow weight, diet digestibility and milk yield. Our objective was to validate the accuracy of this equation using more recent published and unpublished data. Criteria for inclusion in the validation data set included projects conducted or published within the last ten years, direct measurement of forage intake, adequate protein supply, and pen feeding (no tie stall or metabolism crate data). The validation data set included 29 treatment means for gestating cows and 26 treatment means for lactating cows. Means for the gestating cow data set was 11.4 ± 1.9 kg DMI, 599 ± 77 kg BW, 1.24 ± 0.14 Mcal/kg NEm per kg of feed and lactating cow data set was 14.5 ± 2.0 kg DMI, 532 ± 116.3 kg BW, and 1.26 ± 0.24 Mcal NEm per kg feed, respectively. Non intercept models were used to determine equation accuracy in predicting validation data set DMI. The slope for linear bias in the NASEM gestation equation did not differ from 1 (P = 0.07) with a 3.5% positive bias. However, when the NASEM equation was used to predict DMI in lactating cows, the slope for linear bias significantly differed from 1 (P &lt; 0.001) with a downward bias of 13.7%. Therefore, a new multiple regression equation was developed from the validation data set: DMI= (-4.336 + (0.086427 (BW^.75) + 0.3 (Milk yield)+6.005785(NEm)), (R-squared=0.84). The NASEM equation for gestating beef cows was reasonably accurate while the lactation equation underestimated feed intake.
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Sévry, Jean. "Yousaf, Nahem. – Alex La Guma, Politics and Resistance." Cahiers d'études africaines 43, no. 171 (January 1, 2003): 696–97. http://dx.doi.org/10.4000/etudesafricaines.1541.

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42

Prashad, Vijay. "Naeem Mohaiemen’s Tragic History of the 1970s Left." Afterall: A Journal of Art, Context and Enquiry 47 (March 2019): 56–65. http://dx.doi.org/10.1086/704198.

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43

Stanos, Steven P. "National Academies of Sciences, Engineering, and Medicine (NASEM)." Pain Medicine 18, no. 10 (October 1, 2017): 1835–36. http://dx.doi.org/10.1093/pm/pnx224.

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44

Lazović, Ivica. "ISLAMSKE ZAJEDNICE NA POSTJUGOSLOVENSKOM PROSTORU." Srpska politička misao 65, no. 3/2019 (November 1, 2019): 475–91. http://dx.doi.org/10.22182/spm.6532019.21.

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U široj stručnoj javnosti postoji probuđeno interesovanje u poslednjih nekoliko decenija za proučavanjem islamske religije, kulture i civilizacije, a u časopisima su prisutne brojne teme vezane za islam. Ovo interesovanje karakteristično je kako na globalnom, tako i na lokalnom nivou. Takođe, to interesovanje je i multidisciplinarno i karakteristično je za mnoge društvene nauke. Interesovanje za islam je i interkulturalno i preovladava bavljenje islamom i efektima ove velike religije na globalnom nivou, dok je relativno malo pažnje u radovima orijentisano na proučavanje islama na našim prostorima i na sagledavanje i tumačenje stvari u našem okruženju, kao i na prostorima današnje Srbije, uslovno rečeno, u našem dvorištu. U ovom radu smo napravili osvrt na osnovne pojmove o islamu, kao i na organizaciju pripadnika islamske verske zajednice na prostorima bivše zajedničke države. Sve navedeno, upravo je u cilju sagledavanja stvari u našem dvorištu kako bi nam pomoglo i kako bismo bolje tumačili i razumeli pojave na globalnom nivou. U cilju boljeg opisivanja i sistematizovanja već poznatih činjenica o islamu i zajednici muslimana na našim širim prostorima, osvrnućemo se i na osnovne pojmove, običaje i specifičnosti islamske religije. U radu ukazujemo da je islamska zajednica bila veoma prilagodljiva na ovim prostorima i u promenljivim društveno-političkim okolnostima se i sama usklađivala i prilagođavala.
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45

Bradter, Ute, Sundev Gombobaatar, Chuluunbaatar Uuganbayar, Tracy E. Grazia, and Klaus-Michael Exo. "Time budgets and habitat use of White-naped Cranes Grus vipio in the Ulz river valley, north-eastern Mongolia during the breeding season." Bird Conservation International 17, no. 3 (September 2007): 259–71. http://dx.doi.org/10.1017/s0959270907000767.

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AbstractHabitat loss and degradation are critical threats for the globally threatened White-naped Crane Grus vipio. We estimated the size of the area used per day and the time budgets of parental and non-parental White-naped Crane pairs in north-eastern Mongolia during 2000 and 2001. Six parental crane pairs used an area of 11–155 ha per day. The maximum distance of a focal parental crane from the roosting-site was 3,030 m. Habitat conservation measures for breeding White-naped Cranes need to be targeted to within at least 3 km of the roosting-site or nest-site. Parental cranes spent 79.6 ± 4.8% of the daylight period foraging and had reduced preening and resting behaviour to 4.4 ± 1.9%. Pairs without juveniles showed a pronounced period of resting and preening behaviour during midday, which was absent in parental cranes. This indicates that parental cranes may be time-stressed. We conclude that increases in feeding-related activities (e.g. caused by a decrease in food availability) are likely to be at the expense of parental vigilance. Conversely, increases in vigilance (due to e.g. increased disturbance) may have a negative impact on feeding-related activities. Both increases can potentially negatively affect reproductive success in this Vulnerable species.
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Jia, Yifei, Yunzhu Liu, Shengwu Jiao, Jia Guo, Cai Lu, Yan Zhou, Yuyu Wang, Guangchun Lei, Li Wen, and Xunqiang Mo. "Shifting of the Migration Route of White-Naped Crane (Antigone vipio) Due to Wetland Loss in China." Remote Sensing 13, no. 15 (July 29, 2021): 2984. http://dx.doi.org/10.3390/rs13152984.

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In the last 15 years, the west population of white-naped crane (Antigone vipio) decreased dramatically despite the enhanced conservation actions in both breeding and wintering areas. Recent studies highlighted the importance of protecting the integrity of movement connectivity for migratory birds. Widespread and rapid landcover changes may exceed the adaptive capacity of migrants, leading to the collapse of migratory networks. In this study, using satellite tracking data, we modeled and characterized the migration routes of the white-naped crane at three spatial levels (core area, migratory corridor, and migratory path) based on the utilization distribution for two eras (1990s and 2010s) spanning 20 years. Our analysis demonstrated that the white-naped crane shifted its migratory route, which is supported by other lines of evidences. The widespread loss of wetlands, especially within the stopover sites, might have caused this behavioral adaptation. Moreover, our analysis indicated that the long-term sustainability of the new route is untested and likely to be questionable. Therefore, directing conservation effects to the new route might be insufficient for the long-term wellbeing of this threatened crane and large-scale wetland restorations in Bohai Bay, a critical stopover site in the East Asian-Australasian flyway, are of the utmost importance to the conservation of this species.
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Srisai, Dollada, Matthew P. Gillum, Brandon L. Panaro, Xian-Man Zhang, Naiphinich Kotchabhakdi, Gerald I. Shulman, Kate L. J. Ellacott, and Roger D. Cone. "Characterization of the Hyperphagic Response to Dietary Fat in the MC4R Knockout Mouse." Endocrinology 152, no. 3 (March 1, 2011): 890–902. http://dx.doi.org/10.1210/en.2010-0716.

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Defective melanocortin signaling causes hyperphagic obesity in humans and the melanocortin-4 receptor knockout mouse (MC4R−/−). The human disease most commonly presents, however, as haploinsufficiency of the MC4R. This study validates the MC4R+/− mouse as a model of the human disease in that, like the MC4R−/−, the MC4R+/− mouse also exhibits a sustained hyperphagic response to dietary fat. Furthermore, both saturated and monounsaturated fats elicit this response. N-acylphosphatidylethanolamine (NAPE) is a signaling lipid induced after several hours of high-fat feeding, that, if dysregulated, might explain the feeding behavior in melanocortin obesity syndrome. Remarkably, however, MC4R−/− mice produce elevated levels of NAPE and are fully responsive to the anorexigenic activity of NAPE and oleoylethanolamide. Interestingly, additional differences in N-acylethanolamine (NAE) biochemistry were seen in MC4R−/− animals, including reduced plasma NAE levels and elevated hypothalamic levels of fatty acid amide hydrolase expression. Thus, while reduced expression of NAPE or NAE does not explain the high-fat hyperphagia in the melanocortin obesity syndrome, alterations in this family of signaling lipids are evident. Analysis of the microstructure of feeding behavior in response to dietary fat in the MC4R−/− and MC4R+/− mice indicates that the high-fat hyperphagia involves defective satiation and an increased rate of food intake, suggesting defective satiety signaling and enhanced reward value of dietary fat.
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Rocha, Andreia Maria Camargos, Maria Bernadete de Carvalho, Cristina Petersen Cypriano, and Maria Mônica Freitas Ribeiro. "Tratamento Psíquico Prévio ao Ingresso na Universidade: Experiência de um Serviço de Apoio ao Estudante." Revista Brasileira de Educação Médica 44, no. 3 (2020). http://dx.doi.org/10.1590/1981-5271v44.3-20190299.

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Resumo: Introdução: Dados da literatura apontam para um aumento da frequência de sofrimento mental entre estudantes de Medicina. Entretanto, os fatores responsáveis ou que têm contribuído para isso ainda não estão completamente esclarecidos. Conhecê-los é fundamental para o planejamento de um serviço de apoio que acolha, identifique, acompanhe e, se necessário, encaminhe o estudante com sofrimento mental. Método: Avaliamos, neste trabalho, o relato de tratamento psíquico, anterior ao ingresso na universidade, de estudantes do curso de Medicina da Universidade Federal de Minas Gerais que buscaram atendimento no Núcleo de Apoio Psicopedagógico aos Estudantes da Faculdade de Medicina (Napem). Os relatos, os dados sociodemográficos e os motivos que levaram o aluno a procurar o serviço foram obtidos de uma ficha de inscrição preenchida pelo estudante. Resultados: No ano avaliado, 87 estudantes (47 homens, média de idade 23,3 anos) procuraram os serviços do Napem. Desses alunos, 42 (48,3%) cursavam os dois primeiros anos; 24 (27,6%), o terceiro e quarto anos; e 21 (24,1%), o quinto e sexto anos. Tratamento psíquico antes do ingresso na universidade foi relatado por 53 (60,9%) alunos: 37 (42,5%) declararam ter feito uso de medicamentos psicoativos e 16 relataram tratamento com psicoterapia sem medicação. Os relatos de tratamento psíquico e de uso de medicamentos psicoativos antes do ingresso na universidade foram significativamente mais frequentes (p = 0,04 e p = 0,04, respectivamente) entre os estudantes que cursavam os dois primeiros anos do curso do que entre os dos demais anos. Não se observaram diferenças estatisticamente significativas em relação à média de idade (p = 0,06), à distribuição por sexo (p = 0,87), à procedência (p = 0,68) ou ao tipo de moradia em Belo Horizonte (p = 0,96) quando se compararam os grupos com e sem relato de tratamento psíquico. Dentre os motivos apontados para a busca de atendimento no Napem, “ansiedade”, “depressão/sintomas depressivos” e “instabilidade de humor” foram relatados por 59 (67,8%) estudantes. Problemas relacionados ao curso foram declarados por cinco (5,7%) alunos. Conclusão: Os resultados do estudo sugerem que o tratamento psíquico prévio ao ingresso na universidade pode ser um dos fatores que contribuem para o sofrimento mental do estudante de Medicina durante o curso.
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Mazutti, Sandra Regina Gonzaga, Ana Cristina Kuhn Pletsch Roncati, and Délio Eulálio Martins. "Implantação de um programa de mentoria remoto para estudantes de Medicina em tempo de pandemia." Revista Brasileira de Educação Médica 45, suppl 1 (2021). http://dx.doi.org/10.1590/1981-5271v45.supl.1-20210149.

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Resumo: Introdução: Programas de mentoria são necessários para apoio ao estudante de Medicina e podem ter diversos objetivos, dependendo das instituições que os implementam, embora ainda não sejam uma realidade na maioria das universidades. Durante a pandemia da Covid-19, encontros presenciais foram impedidos, o que dificultou ainda mais a manutenção desses programas, apesar de ser um dos momentos de maior necessidade emocional para os alunos. Ajustaram-se as aulas, e os encontros foram transformados em remotos, e, dessa forma, a mentoria on-line passou a ser uma realidade. Relato de experiência: Apoiado pelo Núcleo de Apoio Psicopedagógico dos Estudantes de Medicina (Napem), foi estruturado um programa de mentoria em pequenos grupos, formados por docentes, discentes mais experientes (comentores) e mentorados (alunos do primeiro ao terceiro ano) com reuniões realizadas de forma remota, o que permitiu a participação dos estudantes, a interação com eles e o acolhimento desse público. As reuniões aconteceram entre junho e dezembro de 2020. O programa contou com a participação de 13 mentores, 94 alunos mentorados e 24 comentores. O programa teve uma sessão de treinamento com mentores e comentores, que foi conduzida pela psicóloga do Napem para alinhamento de expectativas e orientações. As discussões nos grupos focaram dificuldades na vida acadêmica, profissional e pessoal. Discussão: O modelo remoto de mentoria apresenta como pontos fortes a maior flexibilidade para mentores e mentorados, a facilidade de participação de ambos e a manutenção da conexão do grupo, pois os encontros são facilitados pela tecnologia, visto que não houve nenhuma desistência. Como ponto fraco dessa experiência, citamos a falta de análises quantitativas e qualitativas do programa utilizando, por exemplo, entrevistas ou questionários de forma científica para avaliar melhor os resultados. Conclusão: A mentoria remota é útil e deve ser incluída como uma possibilidade de legado permanente para os cursos de Medicina, pois os encontros mostraram-se relevantes para mentores e mentorados, e mantiveram-se com alta adesão durante todo o programa.
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Palese, Francesca, Silvia Pontis, Natalia Realini, and Daniele Piomelli. "A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration." Scientific Reports 9, no. 1 (November 4, 2019). http://dx.doi.org/10.1038/s41598-019-51799-1.

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Abstract N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) catalyzes the cleavage of membrane NAPEs into bioactive fatty-acid ethanolamides (FAEs). Along with this precursor role, NAPEs might also serve autonomous signaling functions. Here, we report that injections of 6-hydroxydopamine (6-OHDA) into the mouse striatum cause a local increase in NAPE and FAE levels, which precedes neuronal cell death. NAPE, but not FAE, accumulation is enhanced in mice lacking NAPE-PLD, which display a substantial reduction in 6-OHDA-induced neurotoxicity, as shown by increased survival of substantia nigra dopamine neurons, integrity of striatal dopaminergic fibers, and striatal dopamine metabolite content. Reduced damage is accompanied by attenuation of the motor response evoked by apomorphine. Furthermore, NAPE-PLD silencing protects cathecolamine-producing SH-SY5Y cells from 6-OHDA-induced reactive oxygen species formation, caspase-3 activation and death. Mechanistic studies in mice suggest the existence of multiple molecular contributors to the neuroprotective effects of NAPE-PLD deletion, including suppression of Rac1 activity and attenuated transcription of several genes (Cadps, Casp9, Egln1, Kcnj6, Spen, and Uchl1) implicated in dopamine neuron survival and/or Parkinson’s disease. The findings point to a previously unrecognized role for NAPE-PLD in the regulation of dopamine neuron function, which may be linked to the control of NAPE homeostasis in membranes.
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