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Journal articles on the topic 'Naphthol Biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Hu, Jinyu, Farzaneh Sarrami, Hang Li, et al. "Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system." Chemical Science 10, no. 5 (2019): 1457–65. http://dx.doi.org/10.1039/c8sc02870b.

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2

Thompson, James E., Stephen Fahnestock, Leonard Farrall, Der-Ing Liao, Barbara Valent, and Douglas B. Jordan. "The Second Naphthol Reductase of Fungal Melanin Biosynthesis inMagnaporthe grisea." Journal of Biological Chemistry 275, no. 45 (2000): 34867–72. http://dx.doi.org/10.1074/jbc.m006659200.

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3

Tsuji, Gento, Tomomi Sugahara, Isao Fujii, et al. "Evidence for involvement of two naphthol reductases in the first reduction step of melanin biosynthesis pathway of Colletotrichum lagenarium." Mycological Research 107, no. 7 (2003): 854–60. http://dx.doi.org/10.1017/s0953756203008001.

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4

Kaur, Harmeet, Sudhir Gahlawat, Jasbir Singh, and Balasubramanian Narasimhan. "Molecular Docking Study of Active Diazenyl Scaffolds as Inhibitors of Essential Targets Towards Antimicrobial Drug Discovery." Current Drug Targets 20, no. 15 (2019): 1587–602. http://dx.doi.org/10.2174/1389450120666190618122359.

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Background: The diazenyl compounds (-N=N- linkage) have been reported to have antimicrobial activity. In modern drug discovery, the drug-receptor interactions are generally explored by the molecular docking studies. Materials and Methods: Three categories of diazenyl scaffolds were screened for the docking studies to explore the binding mechanism of interaction with various microbial targets. The diazenyl Schiff bases (SBN-20, SBN-21, SBN-25, SBN-33, SBN-39, SBN-40 and SBN-42), naphthol pharmacophore based diazenyl Schiff bases (NS-2, NS-8, NS-12, NS-15, NS-21, and NS-23), morpholine based dia

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5

Takabatake, T., H. Hara, Y. Ishida, H. Ohta, and K. Kobayashi. "Renal effects of endogenous prostaglandin synthesis promoter ONO-3122." American Journal of Physiology-Renal Physiology 262, no. 6 (1992): F1047—F1054. http://dx.doi.org/10.1152/ajprenal.1992.262.6.f1047.

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The renal effects of a prostaglandin synthesis agonist, 1-iodo-3-aminomethyl-5,6,7,8-tetrahydro-2-naphthol (ONO-3122), were investigated in anesthetized rats. ONO-3122 (0.3 mg/kg + 0.3 mg.kg-1.h-1 iv) doubled the urinary excretion of the main metabolites of prostaglandin F, and induced transient increases in renal blood flow and glomerular filtration rate (GFR) with a marked, stable natriuresis. Indomethacin suppressed the natriuresis. When the diuretic fluid losses were replaced, micropuncture showed an unaltered reabsorption of sodium in the proximal tubule but reductions in the loop of Henl

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Ning, Gang, Hong Ouyang, Songbo Wang та ін. "3′,5′-Cyclic Adenosine Monophosphate Response Element Binding Protein Up-Regulated Cytochrome P450 Lanosterol 14α-Demethylase Expression Involved in Follicle-Stimulating Hormone-Induced Mouse Oocyte Maturation". Molecular Endocrinology 22, № 7 (2008): 1682–94. http://dx.doi.org/10.1210/me.2007-0480.

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Abstract Cytochrome P450 lanosterol 14α-demethylase (CYP51) is a key enzyme in sterols and steroids biosynthesis that can induce meiotic resumption in mouse oocytes. The present study investigated the expression mechanism and function of CYP51 during FSH-induced mouse cumulus oocyte complexes (COCs) meiotic resumption. FSH increased cAMP-dependent protein kinase (PKA) RIIβ level and induced cAMP response element-binding protein (CREB) phosphorylation and CYP51 expression in cumulus cells before oocyte meiotic resumption. Moreover, CYP51 and epidermal growth factor (EGF)-like factor [amphiregul

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7

Ogura, M., Y. Morishima, R. Ohno, et al. "Establishment of a novel human megakaryoblastic leukemia cell line, MEG- 01, with positive Philadelphia chromosome." Blood 66, no. 6 (1985): 1384–92. http://dx.doi.org/10.1182/blood.v66.6.1384.1384.

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Abstract A megakaryoblastic cell line, designated MEG-01, was established from the bone marrow of a patient with blast crisis of Philadelphia (Ph1) chromosome-positive chronic myelogenous leukemia. MEG-01 cells grew in single-cell suspension with a doubling time of 36 to 48 hours. Under the usual culture conditions, approximately half of the cells adhered to the culture flask with extention of pseudopods. MEG-01 cells were positive for the periodic acid-Schiff reaction, alpha-naphthyl acetate esterase, and acid phosphatase, and negative for myeloperoxidase, alpha- naphthyl butyrate esterase, n

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8

Ogura, M., Y. Morishima, R. Ohno, et al. "Establishment of a novel human megakaryoblastic leukemia cell line, MEG- 01, with positive Philadelphia chromosome." Blood 66, no. 6 (1985): 1384–92. http://dx.doi.org/10.1182/blood.v66.6.1384.bloodjournal6661384.

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A megakaryoblastic cell line, designated MEG-01, was established from the bone marrow of a patient with blast crisis of Philadelphia (Ph1) chromosome-positive chronic myelogenous leukemia. MEG-01 cells grew in single-cell suspension with a doubling time of 36 to 48 hours. Under the usual culture conditions, approximately half of the cells adhered to the culture flask with extention of pseudopods. MEG-01 cells were positive for the periodic acid-Schiff reaction, alpha-naphthyl acetate esterase, and acid phosphatase, and negative for myeloperoxidase, alpha- naphthyl butyrate esterase, naphthol A

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9

Donner, Christopher D. "Naphthopyranones – isolation, bioactivity, biosynthesis and synthesis." Natural Product Reports 32, no. 4 (2015): 578–604. http://dx.doi.org/10.1039/c4np00127c.

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This review documents the known naturally occurring naphthopyranones (1H-naphtho[2,3-c]pyran-1-ones) – their isolation, biosynthesis and biological activity. A survey of methods reported for the synthesis of naphthopyranone natural products is also presented.

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10

Hua, Yi, Rui Pan, Xuelian Bai, et al. "Aromatic Polyketides from a Symbiotic Strain Aspergillus fumigatus D and Characterization of Their Biosynthetic Gene D8.t287." Marine Drugs 18, no. 6 (2020): 324. http://dx.doi.org/10.3390/md18060324.

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The chemical investigation of one symbiotic strain, Aspergillus fumigatus D, from the coastal plant Edgeworthia chrysantha Lindl led to the isolation of eight compounds (1–8), which were respectively identified as rubrofusarin B (1), alternariol 9-O-methyl ether (2), fonsecinone D (3), asperpyrone A (4), asperpyrone D (5), fonsecinone B (6), fonsecinone A (7), and aurasperone A (8) by a combination of spectroscopic methods (1D NMR and ESI-MS) as well as by comparison with the literature data. An antimicrobial assay showed that these aromatic polyketides exhibited no remarkable inhibitory effec

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11

Shepherd, Micah D., Tao Liu, Carmen Méndez, Jose A. Salas, and Jürgen Rohr. "Engineered Biosynthesis of Gilvocarcin Analogues with Altered Deoxyhexopyranose Moieties." Applied and Environmental Microbiology 77, no. 2 (2010): 435–41. http://dx.doi.org/10.1128/aem.01774-10.

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ABSTRACTA combinatorial biosynthetic approach was used to interrogate the donor substrate flexibility of GilGT, the glycosyltransferase involved inC-glycosylation during gilvocarcin biosynthesis. Complementation of gilvocarcin mutantStreptomyces lividansTK24 (cosG9B3-U−), in which the biosynthesis of the natural sugar donor substrate was compromised, with various deoxysugar plasmids led to the generation of six gilvocarcin analogues with altered saccharide moieties. Characterization of the isolated gilvocarcin derivatives revealed five new compounds, including 4-β-C-d-olivosyl-gilvocarcin V (d

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12

Takenaka, Yukiko, Nobuo Hamada, and Takao Tanahashi. "Structure and Biosynthesis of Lecanopyrone, a Naphtho[1,8-cd]pyran-3-one Derivative from Cultured Lichen Mycobionts of Lecanora leprosa." Zeitschrift für Naturforschung C 65, no. 11-12 (2010): 637–41. http://dx.doi.org/10.1515/znc-2010-11-1201.

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From the cultures of spore-derived mycobionts of the lichen Lecanora leprosa a novel naphtho[1,8-cd]pyran-3-one derivative, lecanopyrone, was isolated. Its structure was determined by spectroscopic methods. The assembly pattern of acetate units in its biosynthesis was verified using sodium [1-13C]-acetate and sodium [1,2-13C2]-acetate

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13

Zheng, Yao-Yao, Zhao-Yang Liang, Nan-Xing Shen та ін. "New Naphtho-γ-Pyrones Isolated from Marine-Derived Fungus Penicillium sp. HK1-22 and Their Antimicrobial Activities". Marine Drugs 17, № 6 (2019): 322. http://dx.doi.org/10.3390/md17060322.

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Three novel monomeric naphtho-γ-pyrones, peninaphones A–C (compounds 1–3), along with two known bis-naphtho-γ-pyrones (compounds 4 and 5) were isolated from mangrove rhizosphere soil-derived fungus Penicillium sp. HK1-22. The absolute configurations of compounds 1 and 2 were determined by electronic circular dichroism (ECD) spectra, and the structure of compound 3 was confirmed by single-crystal X-ray diffraction analysis. Compounds 4 and 5 are a pair of hindered rotation isomers. A hypothetical biosynthetic pathway for the isolated monomeric and dimeric naphtho-γ-pyrones is also discussed in

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14

Mansour, Tarek S, Craig E Caufield, Beth Rasmussen, et al. "Naphthyl Tetronic Acids as Multi-Target Inhibitors of Bacterial Peptidoglycan Biosynthesis." ChemMedChem 2, no. 10 (2007): 1414–17. http://dx.doi.org/10.1002/cmdc.200700094.

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15

Praveena, Ganji, Swetha Yagnam, Linga Banoth, Rajiv Trivedi, and Reddy Shetty Prakasham. "Correction: Bacterial biosynthesis of nanosilver: a green catalyst for the synthesis of (amino pyrazolo)-(phenyl)methyl naphth-2-ol derivatives and their antimicrobial potential." New Journal of Chemistry 44, no. 37 (2020): 16246. http://dx.doi.org/10.1039/d0nj90128h.

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Correction for ‘Bacterial biosynthesis of nanosilver: a green catalyst for the synthesis of (amino pyrazolo)-(phenyl)methyl naphth-2-ol derivatives and their antimicrobial potential’ by Ganji Praveena et al., New J. Chem., 2020, 44, 13046–13061, DOI: 10.1039/D0NJ01924K.

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16

Kolkmann, Rainer, and Eckhard Leistner. "4-(2′-Carboxyphenyl)-4-oxobutyryl Coenzyme A Ester, an Intermediate in Vitamin K2 (Menaquinone) Biosynthesis." Zeitschrift für Naturforschung C 42, no. 11-12 (1987): 1207–14. http://dx.doi.org/10.1515/znc-1987-11-1212.

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Enzyme preparations from Mycobacterium phlei, Escherichia coli and Galium mollugo cell suspension cultures were incubated in the presence of 4-(2′-carboxyphenyl)-4-oxobutyrate (i.e. o- succinylbenzoic acid. OSB. 1). ATP. coenzyme A and Mg2+. The main product isolated from the incubation mixture was 4-(2′-carboxyphenyl)-4-oxobutyryl coenzyme A ester (2) as determined by comparison with synthetic coenzyme A esters. Synthetic and enzymically formed 4-(2′-car-boxyphenyl)-4-oxobutyryl coenzyme A ester (2) was shown to be enzymically converted to an intermediate in vitamin K2 biosynthesis viz. 1.4-d

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17

KOYAMA, Kiyotaka, and Shinsaku NATORI. "Biosynthesis of chaetochromin A, a bis(naphtho-.GAMMA.-pyrone), in Chaetomium spp." CHEMICAL & PHARMACEUTICAL BULLETIN 37, no. 8 (1989): 2022–25. http://dx.doi.org/10.1248/cpb.37.2022.

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18

Bashiri, Ghader, Laura V. Nigon, Ehab N. M. Jirgis, et al. "Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis." Journal of Biological Chemistry 295, no. 12 (2020): 3759–70. http://dx.doi.org/10.1074/jbc.ra119.012158.

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Menaquinone (vitamin K2) plays a vital role in energy generation and environmental adaptation in many bacteria, including the human pathogen Mycobacterium tuberculosis (Mtb). Although menaquinone levels are known to be tightly linked to the cellular redox/energy status of the cell, the regulatory mechanisms underpinning this phenomenon are unclear. The first committed step in menaquinone biosynthesis is catalyzed by MenD, a thiamine diphosphate–dependent enzyme comprising three domains. Domains I and III form the MenD active site, but no function has yet been ascribed to domain II. Here, we sh

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19

Suvarna, K., D. Stevenson, R. Meganathan, and M. E. S. Hudspeth. "Menaquinone (Vitamin K2) Biosynthesis: Localization and Characterization of the menA Gene fromEscherichia coli." Journal of Bacteriology 180, no. 10 (1998): 2782–87. http://dx.doi.org/10.1128/jb.180.10.2782-2787.1998.

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ABSTRACT A key reaction in the biosynthesis of menaquinone involves the conversion of the soluble bicyclic naphthalenoid compound 1,4-dihydroxy-2-naphthoic acid (DHNA) to the membrane-bound demethylmenaquinone. The enzyme catalyzing this reaction, DHNA-octaprenyltransferase, attaches a 40-carbon side chain to DHNA. The menA gene encoding this enzyme has been cloned and localized to a 2.0-kb region of the Escherichia coli genome between cytR and glpK. DNA sequence analysis of the cloned insert revealed a 308-codon open reading frame (ORF), which by deletion analyses was shown to restore anaerob

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20

Jiang, Ming, Minjiao Chen, Zu-Feng Guo, and Zhihong Guo. "A Bicarbonate Cofactor Modulates 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase in Menaquinone Biosynthesis ofEscherichia coli." Journal of Biological Chemistry 285, no. 39 (2010): 30159–69. http://dx.doi.org/10.1074/jbc.m110.147702.

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21

Иванова, Светлана, Svetlana Ivanova, Ирина Милентьева, et al. "Biologically Active Substances of Siberian Medical Plants in Functional Wgey-Based Drinks." Food Processing: Techniques and Technology 49, no. 1 (2019): 14–22. http://dx.doi.org/10.21603/2074-9414-2019-1-14-22.

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The use of infusions and extracts from domestic plant materials is a promising direction in the development of functional beverages since they contain a wide range of substances of various pharmacological properties. Drinks fortified with physiologically active natural components maintain a certain level of this content in human body. They can have a healing or prophylactic effect. However, there is a lack of technologies for the effective production of biologically active substances from plant materials. Moreover, the development of cultivated botanical medicinal plant species remains quite p

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22

Furt, Fabienne, William J. Allen, Joshua R. Widhalm, et al. "Functional convergence of structurally distinct thioesterases from cyanobacteria and plants involved in phylloquinone biosynthesis." Acta Crystallographica Section D Biological Crystallography 69, no. 10 (2013): 1876–88. http://dx.doi.org/10.1107/s0907444913015771.

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The synthesis of phylloquinone (vitamin K1) in photosynthetic organisms requires a thioesterase that hydrolyzes 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to release 1,4-dihydroxy-2-naphthoate (DHNA). Cyanobacteria and plants contain distantly related hotdog-fold thioesterases that catalyze this reaction, although the structural basis of these convergent enzymatic activities is unknown. To investigate this, the crystal structures of hotdog-fold DHNA-CoA thioesterases from the cyanobacteriumSynechocystis(Slr0204) and the flowering plantArabidopsis thaliana(AtDHNAT1) were determined. These enzymes

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23

Widhalm, Joshua R., Anne-Lise Ducluzeau, Nicole E. Buller, Christian G. Elowsky, Laura J. Olsen, and Gilles J. C. Basset. "Phylloquinone (vitamin K1) biosynthesis in plants: two peroxisomal thioesterases of lactobacillales origin hydrolyze 1,4-dihydroxy-2-naphthoyl-coa." Plant Journal 71, no. 2 (2012): 205–15. http://dx.doi.org/10.1111/j.1365-313x.2012.04972.x.

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24

Song, HaiGang, and ZhiHong Guo. "Characterization of 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in phylloquinone biosynthesis of Synechocystis sp. PCC 6803." Science China Chemistry 55, no. 1 (2011): 98–105. http://dx.doi.org/10.1007/s11426-011-4448-y.

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25

Song, Haigang, Hoi Pang Sung, Yuk Sing Tse, Ming Jiang, and Zhihong Guo. "Ligand-dependent active-site closure revealed in the crystal structure ofMycobacterium tuberculosisMenB complexed with product analogues." Acta Crystallographica Section D Biological Crystallography 70, no. 11 (2014): 2959–69. http://dx.doi.org/10.1107/s1399004714019440.

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1,4-Dihydroxy-2-naphthoyl coenzyme A (DHNA-CoA) synthase catalyzes an essential intramolecular Claisen condensation in menaquinone biosynthesis and is an important target for the development of new antibiotics. This enzyme inMycobacterium tuberculosisis cofactor-free and is classified as a type II DHNA-CoA synthase, differing from type I enzymes, which rely on exogenous bicarbonate for catalysis. Its crystal structures in complex with product analogues have been determined at high resolution to reveal ligand-dependent structural changes, which include the ordering of a 27-residue active-site l

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26

Ding, Wei, Wei Deng, Mancheng Tang, et al. "Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B." Molecular BioSystems 6, no. 6 (2010): 1071. http://dx.doi.org/10.1039/b926358f.

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27

Hang, Vu Thi Thu, Tae Jin Oh, Tokutaro Yamaguchi, and Jae Kyung Sohng. "In vivo characterization of NcsB3 to establish the complete biosynthesis of the naphthoic acid moiety of the neocarzinostatin chromophore." FEMS Microbiology Letters 311, no. 2 (2010): 119–25. http://dx.doi.org/10.1111/j.1574-6968.2010.02075.x.

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28

Jo, Jungman, Yongtae Ahn, Kalimuthu Pandi, et al. "Assessment of Soil Contamination by Gas Cloud Generated from Chemical Fire Using Metabolic Profiling and Associated Bacterial Communities." Minerals 11, no. 4 (2021): 372. http://dx.doi.org/10.3390/min11040372.

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Chemical accidents have frequently occurred in South Korea as a result of the huge amount of chemicals being used in various industries. Even though fire accidents accounted for 71.9% of chemical accidents during 2008–2018 in South Korea, most ecological research and investigation has focused on leakage accidents since most fire or explosion gases are diffused out and disappear into the atmosphere. In this study, the possibility of soil contamination by toluene combustion is proposed. A fire simulation batch test was performed and identified the combustion by-products such as methylbenzene, et

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29

Sun, Yueru, Haigang Song, Jie Li, et al. "Active Site Binding and Catalytic Role of Bicarbonate in 1,4-Dihydroxy-2-naphthoyl Coenzyme A Synthases from Vitamin K Biosynthetic Pathways." Biochemistry 51, no. 22 (2012): 4580–89. http://dx.doi.org/10.1021/bi300486j.

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30

Cooke, Heather A., Jian Zhang, Meghan A. Griffin, et al. "Characterization of NcsB2 as a Promiscuous Naphthoic Acid/Coenzyme A Ligase Integral to the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin." Journal of the American Chemical Society 129, no. 25 (2007): 7728–29. http://dx.doi.org/10.1021/ja071886a.

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31

Luo, Yinggang, Shuangjun Lin, Jian Zhang, Heather A. Cooke, Steven D. Bruner, and Ben Shen. "Regiospecific O-Methylation of Naphthoic Acids Catalyzed by NcsB1, an O-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin." Journal of Biological Chemistry 283, no. 21 (2008): 14694–702. http://dx.doi.org/10.1074/jbc.m802206200.

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32

Oppong-Danquah, Ernest, Paulina Budnicka, Martina Blümel, and Deniz Tasdemir. "Design of Fungal Co-Cultivation Based on Comparative Metabolomics and Bioactivity for Discovery of Marine Fungal Agrochemicals." Marine Drugs 18, no. 2 (2020): 73. http://dx.doi.org/10.3390/md18020073.

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Microbial co-cultivation is employed for awakening silent biosynthetic gene clusters (BGCs) to enhance chemical diversity. However, the selection of appropriate partners for co-cultivation remains a challenge. Furthermore, competitive interactions involving the suppression of BGCs or upregulation of known, functional metabolite(s) during co-cultivation efforts is also common. Herein, we performed an alternative approach for targeted selection of the best co-cultivation pair. Eight marine sediment-derived fungi were classified as strong or weak, based on their anti-phytopathogenic potency. The

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33

Vaccaro, Mariacarmela, Vivian Ocampo Bernal, Nicola Malafronte, Nunziatina De Tommasi, and Antonietta Leone. "High Yield of Bioactive Abietane Diterpenes in Salvia sclarea Hairy Roots by Overexpressing Cyanobacterial DXS or DXR Genes." Planta Medica 85, no. 11/12 (2019): 973–80. http://dx.doi.org/10.1055/a-0895-5878.

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AbstractAbietane diterpenoids, containing a quinone moiety, are synthesized in the roots of several Salvia species. Promising cytotoxicity and antiproliferative activities have been reported for these compounds in various cell and animal models. We have recently shown that aethiopinone, an o-naphto-quinone diterpene, produced in the roots of different Salvia species, is selectively cytotoxic against the A375 melanoma cell line. To enhance the synthesis of this abietane diterpenoid, we have engineered the plastidial 2-C-methyl-D-erythritol 4-phosphate-derived isoprenoid pathway in Salvia sclare

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PFEFFERLE, C., J. BREINHOLT, H. GUERTLER, and H. P. FIEDLER. "ChemInform Abstract: Biosynthetic Capacities of Actinomycetes. Part 9. 1-Hydroxy-4-methoxy-2-naphthoic Acid, a Herbicidal Compound Produced by Streptosporangium cinnabarinum ATCC 31213." ChemInform 29, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199822159.

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Sone, Yusuke, Shuto Nakamura, Makoto Sasaki, Fumihito Hasebe, Seung-Young Kim, and Nobutaka Funa. "Bacterial Enzymes Catalyzing the Synthesis of 1,8-Dihydroxynaphthalene, a Key Precursor of Dihydroxynaphthalene Melanin, fromSorangium cellulosum." Applied and Environmental Microbiology 84, no. 9 (2018). http://dx.doi.org/10.1128/aem.00258-18.

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ABSTRACT1,8-Dihydroxynaphthalene (1,8-DHN) is a key intermediate in the biosynthesis of DHN melanin, which is specific to fungi. In this study, we characterized the enzymatic properties of the gene products of an operon consisting ofsoceCHS1,bdsA, andbdsBfrom the Gram-negative bacteriumSorangium cellulosum. Heterologous expression ofsoceCHS1,bdsA, andbdsBinStreptomyces coelicolorcaused secretion of a dark-brown pigment into the broth. High-performance liquid chromatography (HPLC) analysis of the broth revealed that the recombinant strain produced 1,8-DHN, indicating that the operon encoded a n

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Hu, Yue, Fang Chen, Haiyong Ye, and Bin Lu. "Integrative analysis of the gut microbiome and metabolome in a rat model with stress induced irritable bowel syndrome." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-97083-z.

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AbstractStress is one of the major causes of irritable bowel syndrome (IBS), which is well-known for perturbing the microbiome and exacerbating IBS-associated symptoms. However, changes in the gut microbiome and metabolome in response to colorectal distention (CRD), combined with restraint stress (RS) administration, remains unclear. In this study, CRD and RS stress were used to construct an IBS rat model. The 16S rRNA gene sequencing was used to characterize the microbiota in ileocecal contents. UHPLC-QTOF-MS/MS assay was used to characterize the metabolome of gut microbiota. As a result, sig

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Yu, Han, Chao Liu, Fenghua Zhang, et al. "Efficacy of Zhuyu Pill Intervention in a Cholestasis Rat Model: Mutual Effects on Fecal Metabolism and Microbial Diversity." Frontiers in Pharmacology 12 (September 2, 2021). http://dx.doi.org/10.3389/fphar.2021.695035.

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Cholestasis is a clinical condition resulting from impaired bile flow. Currently, patients with cholestasis face several barriers in seeking diagnosis and treatment. Zhuyu Pill (ZYP) is an ancient classic formula of the Coptis-Evodia herb couples (CEHC), and has been used for cholestasis treatment in the clinic, however, its underlying biological activity in cholestasis remain to be clarified. In this study, an α-naphthyl-isothiocyanate (ANIT, 50 mg/kg)-induced rat model of cholestasis was treated with ZYP. Serum biochemical indices and histopathological evaluation was performed, together with

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