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Dissertations / Theses on the topic 'Naphthoquinone'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Jones, Karen. "The basis for naphthoquinone and biguanide synergy." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368631.

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2

Musa, Yusuf. "Studies of 1,2-naphthoquinone mono-oximato complexes." Thesis, London Metropolitan University, 1991. http://repository.londonmet.ac.uk/3286/.

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The synthesis of 1,2-naphthoquinone I-oxime and 1,2- naphthoquinone 2-oxina complexes of rhodium and Iridium has been Investigated. In the case of rhodium, complexes of the type Rh(l-nqo)3 have been prepared by reacting 1 ,2-naphthoquinone 1-oxime with hydrated rhodium(III) chloride. Both products ware obtained as mixtures of isomers. The Interaction of 1,2- naphthoquinone 2-oxime with rhodium(lll) chloride yielded Rh(2-nqo)3 also as a mixture of Isomers. The trichelates were also obtained from the nitrosation of the appropriate naphthol in the presence of rhodium(Ill) chloride. In contrast, t

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3

Stoten, William C. "1,2-naphthoquinone mono-oximato complexes of ruthenium." Thesis, London Metropolitan University, 1988. http://repository.londonmet.ac.uk/3429/.

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The ruthenium(II) complexes Ru(nqo)2 (nqoH = 1,2-naphthoqulnona 1-oxima, or 2-oxima) were prepared by the interaction of the sodium salts of the 112-naphthoquinone mono-oximes with hydrated ruthenium(III) chloride in aqueous tetrahydrofuran.

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4

Fisher, Kimberly D. "Thermal rearrangement of 4-aryl-4-hydroxy-2-cyclobuten-1-ones and application of the methodology in the formation of benzofuronaphthoquinones and benzocarbazolequinones." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5872.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xvi, 200 p. : ill. Includes abstract. Includes bibliographical references (p. 95-97).

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5

De, Koning Charles Bernard. "The syntheses of some naturally derived naphthoquinones." Doctoral thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/22000.

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Bibliography: pages 193-195.<br>The synthesis of the naphthalene core of the ansamycin antibiotics, 8-acetyl-3-acetylamino-5,7-dihydroxy-1,4-naphthoquinone from benzoquinone by means of simple reactions including, Diels-Alder adduct formation, mild acetylation, oxime formation and Beckmann rearrangement in five steps with an overall yield of 22% is described in Chapter 1. The synthesis of the naturally occurring naphthoquinone derivative, possessing anti tumour and antiprotozoal properties, bikaverin is described in Chapter 2. Starting from vanillin the key intermediate 2-(2'-benzyloxy-6'-meth

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6

Song, Ronghui. "Synthesis, Characterization and Antimicrobial Properties of Novel Naphthoquinone Derivatives." Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1586783242508385.

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7

Bapela, Mahwahwatse Johanna. "Variation of active constituents in Euclea natalensis based on seedling stages, seasons, and fertilizers." Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-06262008-095522/.

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8

Brenstrum, Timothy James. "Studies towards the synthesis of medermycin." Phd thesis, Department of Organic Chemistry, 1999. http://hdl.handle.net/2123/8846.

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9

Yatchang, Marina Fosso. "Synthesis and Biological Activity of Aminoglycosides and 1,4-Naphthoquinone Derivatives." DigitalCommons@USU, 2012. https://digitalcommons.usu.edu/etd/1371.

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The research described in this dissertation is at the interface of organic chemistry and biology, and it aimed at designing and synthesizing biologically active molecules for the possible development of therapeutic agents. Spinal muscular atrophy is an incurable disease that affects 1 in every 6000 babies, making it the leading genetic cause of infant mortality. While no treatment is available, efforts are being taken to solve this issue. Part of the work outlined in this dissertation was carried out in collaboration with researchers from the University of Missouri to investigate a potential t

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10

Mahmood, Tariq. "Aspects of the chemistry of 1,4-naphthoquinones : an investigation of nucleophilic substitution reactions of alkylamines and hydroxyalyklamines on 1,4 napthoquinones and the role of solvent on the position of substitution." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5746.

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Nucleophilic substitution reactions of alkylamines, cyclic alkylamines, and hydroxyalkylamines with 5-substituted-1,4-naphthoquinones have been studied. It has been found that the nature of the solvent employed in the reaction influences the position of mono-substitution at either the 2- or 3-position. Although both regioisomers were produced in all the reactions, protic polar solvents favoured the formation of the 3-regioisomer, whereas non-protic solvents favoured the formation of the 2-regioisomer. It has also been found that formation of 2,3-diaminoalkyl derivatives is normally unlikely. A

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11

劉曉霞 and Xiaoxia Liu. "Coordination Chemistry of 1,2-naphthoquinone-mono-oxime withruthenium, rhodium and palladium." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B3124063X.

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12

Dos, Reis Ferreira Claudio. "Polyhydroxylated Naphthoquinone Pigments in Biomineral Coloration of Paracentrotus lividus Sea Urchins." Electronic Thesis or Diss., Sorbonne université, 2025. http://www.theses.fr/2025SORUS031.

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Les oursins présentent des couleurs vives en raison de la présence de pigments de naphtoquinone polyhydroxylée (PHNQ) dans leur squelette biominéralisé (test et épines). Les PHNQs sont synthétisés dans des cellules spécialisées appelées cellules à sphérules rouges (RSCs). Les mécanismes de libération des PHNQs et de leur incorporation dans le minéral restent inconnus. Paracentrotus lividus présente généralement des couleurs violettes et vertes, et la relation chimique entre la composition des PHNQs et la couleur du biominéral est peu étudiée. Nous montrons ici que la couleur violette est due à

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13

Liu, Xiaoxia. "Coordination Chemistry of 1,2-naphthoquinone-mono-oxime with ruthenium, rhodium and palladium /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2168781X.

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14

Sardhalia, Vaskar. "Calcium carbonate-naphthoquinone hybrid pigments inspired by biomineral coloration in sea urchins." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS644.pdf.

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Les couleurs vives observées dans les biominéraux provenant d'oursins adultes, allant du violet au vert, sont attribuées à la présence de molécules de naphtoquinone polyhydroxylée (PHNQs). Ces PHNQs sont intégrés dans la calcite, probablement au cours de la croissance cristalline, se produisant via l'intermédiaire de précurseurs de carbonate de calcium amorphe (ACC). La formation de minéraux chez les oursins s'accompagne de changements de couleur dépendant du stade de minéralisation. Le spinochrome A, par exemple, présente une couleur rouge lorsqu'il est extrait des épines violettes de Paracen

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15

García-Martínez, Israel. "Microwave assisted solid-supported organic systhesis a novel development of a methodology to obtain 2,3-disubstituted-1,4-naphthoquinones /." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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16

McManus, Joshua David. "A search for shorter, more convergent routes to enantiopure naphthopyrans related to the aphid insect pigments." Thesis, McManus, Joshua David (2007) A search for shorter, more convergent routes to enantiopure naphthopyrans related to the aphid insect pigments. PhD thesis, Murdoch University, 2007. https://researchrepository.murdoch.edu.au/id/eprint/695/.

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The naphtho[2,3-c]pyran ring system is generally found amongst natural products as the 5,10- or 6,9-quinones. These compounds display a wide range of biological activities, and as such, have been synthesised by various research groups. The synthetic work described in this thesis is directed towards finding shorter, more convergent routes to enantiopure quinone A 10, quinone A' 11 and quinone-pm 13, three derivatives of the aphid insect pigments protoaphin-fb 6, protoaphin-sl 7 and protoaphin-pm 9, respectively. The first chapter describes the previous syntheses of some naphtho[2,3-c]pyra

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17

McManus, Joshua David. "A search for shorter, more convergent routes to enantiopure naphthopyrans related to the aphid insect pigments." McManus, Joshua David (2007) A search for shorter, more convergent routes to enantiopure naphthopyrans related to the aphid insect pigments. PhD thesis, Murdoch University, 2007. http://researchrepository.murdoch.edu.au/695/.

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The naphtho[2,3-c]pyran ring system is generally found amongst natural products as the 5,10- or 6,9-quinones. These compounds display a wide range of biological activities, and as such, have been synthesised by various research groups. The synthetic work described in this thesis is directed towards finding shorter, more convergent routes to enantiopure quinone A 10, quinone A' 11 and quinone-pm 13, three derivatives of the aphid insect pigments protoaphin-fb 6, protoaphin-sl 7 and protoaphin-pm 9, respectively. The first chapter describes the previous syntheses of some naphtho[2,3-c]pyran

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18

Oosthuizen, Francois Jacobus. "Synthesis of hongconin and related naphtho[2,3-c]pyrans." Thesis, Cape Technikon, 1995. http://hdl.handle.net/20.500.11838/746.

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Thesis (MTech(Chemistry))--Cape Technikon, Cape Town,1995<br>The naphtho[2,3-c]pyran occurs frequently in nature as derivatives of the 5,10 quinones. The most common examples include the eleutherins and protoaphins. These naturally occurring compounds have been found to possess antibiotic activity through the process of bioactivation. The possibility of appropriately substituted compounds functioning as bioreductive alkylating agents provides a logical model that has a great deal of predictive power. The thesis deals with the synthesis of some naphtho[2,3-c]pyrans to be tested biologica

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19

Silva, Eliane de Oliveira. "Estudos sobre o metabolismo microbiano de naftoquinonas e avaliação da citotoxicidade dos metabólitos obtidos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-26032014-094822/.

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Muitas naftoquinonas como o lapachol, podem ser encontradas em plantas da família Bignoniaceae e são conhecidas por desempenharem diversas atividades biológicas, acompanhadas, entretanto, por efeitos indesejáveis. A atividade citotóxica apresentada pelas naftoquinonas está relacionada ao aparecimento de espécies reativas de oxigênio in vivo que causam severo estresse oxidativo no interior das células. O isolapachol e a atovaquona são análogos estruturais do lapachol, sendo que a atovaquona é comercializada como fármaco para o tratamento de malária e certos tipos de pneumonia. Devido ao grande

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20

Chakaingesu, Chikomborero. "Synthesis and structure-activity relationship studies of 1,4-naphthoquinone derivatives as potential anti-trypanosomal agents." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1020959.

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Human African Trypanosomiasis (HAT) is an infectious, vector-borne protozoal disease which is amongst the so-called neglected diseases. In 2000, at a summit of the United Nations, eight Millennium Development Goals (MDGs) were set, to be achieved by 2015. MDG 6 states “to combat HIV/AIDS, malaria & other diseases”. With just under 2 years to go before the end of 2015, HAT is still thriving in developing countries. The drugs currently used for the treatment of HAT are in short supply, have severe side effects and those used to treat late stages of the disease are very difficult to administer. T

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21

Cardoso, Mariana Filomena do Carmo. "Síntese de derivados 5-amino-1H-pirazólicos da nor-β-lapachona com potencial perfil anticancerígeno". Niterói, 2017. https://app.uff.br/riuff/handle/1/3283.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-04-04T18:00:06Z No. of bitstreams: 1 Cardoso, Mariana Filomena do Carmo [Dissertação, 2012].pdf: 7461706 bytes, checksum: 1ba99c29719229ef773ca5d72b10c91f (MD5)<br>Made available in DSpace on 2017-04-04T18:00:06Z (GMT). No. of bitstreams: 1 Cardoso, Mariana Filomena do Carmo [Dissertação, 2012].pdf: 7461706 bytes, checksum: 1ba99c29719229ef773ca5d72b10c91f (MD5)<br>Esse trabalho descreve uma nova metodologia sintética de novos derivados pirazólicos análogos a 2,2-dimetil-2,3-di-hidronafto[1,2-b]furan-4,5-diona (nor-β

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22

Shrestha, Jaya P. "Synthesis, Structure-Activity Relationship Study, and Mode of Action Study of 1,4-Naphthoquinone Based Anticancer and Antimicrobial Agents." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4925.

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Synthesizing bioactive small molecules by structural modification of 1,4-naphthoquinone was the primary goal of this research. Several bioactive compounds with anticancer, antifungal, and antibacterial activities were synthesized. All the synthetic protocols were optimized in such ways that do not require cumbersome purification. First, a new protocol for the synthesis of NQM111 was developed. NQM111 is a highly potent anticancer agent developed in our laboratory, but the old protocol does not provide enough quantity for in vivo study. Therefore, a new safe and improved method was developed wh

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23

Yamada, Hisatsugu. "Studies on naphthoquinone-sensitized one-electron photooxidation at 5-methylcytosine in DNA and its application to DNA methylation analysis." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/136304.

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Santos, Evelyne Alves dos. "Estudo da Atividade CitotÃxica da Alfa-Lapachona e seu Derivado Tetrahidropirano." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10440.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>As quinonas sÃo metabÃlitos de ampla distribuiÃÃo na natureza que possuem diversas atividades farmacolÃgicas de importÃncia clÃnica. A naftoquinona α-lapachona demonstrou potencial como protÃtipo para o desenvolvimento de substÃncias com propriedades anticÃncer, como relatado pelo nosso grupo de pesquisa, em que o seu derivado tetrahidropirano (THP) apresentou citotoxicidade e seletividade significante contra a linhagem de melanoma MDA-MB-435. Assim, o objetivo deste trabalho foi avaliar o mecanismo de aÃÃo envolvid

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CRUZ, Jackson Borba da. "Arcabouços de quitosana/agente antineoplásico: síntese, caracterização e aplicação." Universidade Federal de Campina Grande, 2015. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/1033.

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Submitted by Maria Medeiros (maria.dilva1@ufcg.edu.br) on 2018-06-25T14:25:31Z No. of bitstreams: 1 JACKSON BORBA DA CRUZ - TESE (PPGCEMat) 2015.pdf: 4572910 bytes, checksum: 529c14d2c73d94769063607a9a287e65 (MD5)<br>Made available in DSpace on 2018-06-25T14:25:31Z (GMT). No. of bitstreams: 1 JACKSON BORBA DA CRUZ - TESE (PPGCEMat) 2015.pdf: 4572910 bytes, checksum: 529c14d2c73d94769063607a9a287e65 (MD5) Previous issue date: 2015-05-22<br>As neoplasias constituem um conjunto de doenças que se caracterizam por uma massa anormal de tecido com crescimento descontrolado e excessivo em relação ao

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Liu, Yixi. "Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/52259.

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As part of an International Cooperative Biodiversity Group (ICBG) program and a continuing search for antiproliferative natural products from the Madagascar rainforest, and a collaborative research project established between Virginia Tech and the Institute for Hepatitis and Virus Research (IHVR) focusing on searching for bioactive natural products from tropical forests in South Africa, 20 extracts were selected for investigation based on their antiproliferative activities against A2780 human ovarian cancer cell line or antimalarial activities against the Dd2 strain of Plasmodium falciparum. B

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Bulovas, Arūnas. "Self-assembled monolayers of biomimetic (methyl)naphthoquinone omega-mercapto derivatives on gold and silver surfaces: electrochemical and spectroscopic studies of redox conversion and structure." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100204_103028-93997.

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A large set of biomimetic 1,4-naphthoquinone mercapto derivatives varying in the side-chain length and intrachain functional groups was synthesized. Interfacial redox processes and fine structure of self-assembled monolayers formed from newly synthesized compounds on gold and silver were studied by cyclic voltammetry and surface-enhanced Raman spectroscopy.Mixed monolayers of naphthoquinone derivatives and different redox inactive alkylthiols were studied. Low-density naphthoquinone-based monolayers were studied more thoroughly.<br>Sintezuotas didelis rinkinys biomimetinių 1,4-naftochinono mer

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Zhang, Jianjun. "Library Synthesis of Anticancer and Antibacterial Agents via Azide Chemistry." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/711.

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Various anticancer and antibacterial agents have been synthesized via azide chemistry by taking advantage of carbohydrate. Starting from the synthesis of 14 glycosyl azides, a library of carbohydrate-oxazolidinone conjugates and a library of carbohydrate-cyclopamine conjugates with biological interests were synthesized based on a highly efficient "click reaction" assisted by sonication. Some of the conjugates have improved solubility and enhanced anticancer activity. A library of neomycin B derivatives with various modifications at the 5" position has been synthesized. Two leads exhibit

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Lin, Zhu Qing. "Protective effects of, 2-methoxy-6-acetyl-7-methyljuglone, a naphthoquinone in Polygonum cuspidatum (Hu-Zhang), against PC12 apoptosis induced by tert-butyl hydroperoxide." Thesis, University of Macau, 2009. http://umaclib3.umac.mo/record=b2158130.

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Jelly, Renee Michelle. "Natural products as novel reagents for the detection of latent fingermarks." Thesis, Curtin University, 2010. http://hdl.handle.net/20.500.11937/2079.

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The ability to detect latent fingermarks on porous surfaces, such as paper-based documents, is extremely important in resolving criminal cases. Detection methods that target amino acids present in latent fingermark deposits have achieved widespread use. This is due to the chemical stability of this component of the eccrine secretion and the binding of the amino acids to paper fibres, thus resulting in a good representation of the fingermark. This dissertation presents studies into the ability of naphthoquinones to develop latent fingermarks on paper surfaces. These compounds represent a comple

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Ta, Chieu Anh Kim. "Bacterial Biofilm Inhibition and Antifungal Activity of Neotropical Plants." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32419.

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This thesis examined the antimicrobial activity of select neotropical plants from Costa Rica and traditional Q’eqchi Maya medicines from Belize. In particular the potential for interference with bacterial quorum sensing (QS) and biofilm formation as well as fungal growth were assessed. Of one hundred and twenty six extracts collected from Costa Rica, one third showed significant QS inhibition while 13 species displayed more biofilm inhibitory activities than the positive control allicin. The active species belonged to the Lepidobotryaceae, Melastomataceae, Meliaceae, Sapindaceae, and Simarouba

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Moyo, Buhle. "The screening and characterisation of compounds for modulators of heat shock protein (Hsp90) in a breast cancer cell model." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1004129.

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Breast cancer is a leading cause of cancer death in Africa. Hsp90 has been identified as a target for anti-cancer treatments as its inhibition results in the disruption and ubiquitin–proteasome degradation of activated oncoproteins. Currently, there are no US Food and Drug Administration approved Hsp90 inhibitor drugs and existing Hsp90 inhibitors such as geldanamycin and novobiocin are hepatotoxic and display a low affinity for Hsp90, respectively. Therefore, there is a need for the development of Hsp90 inhibitors with improved inhibitory properties. In this study twelve natural compounds bea

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Castro, Murilo Fagundes de. "Avaliação da atividade anti-trypanosoma cruzi in vitro e in vivo de derivados de vitamina K." Centro de Pesquisas Gonçalo Moniz, 2012. https://www.arca.fiocruz.br/handle/icict/7182.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2013-10-18T18:15:09Z No. of bitstreams: 1 Murilo F. Castro. Avaliação da atividade,,, 2012.pdf: 1468986 bytes, checksum: 7b9241cb49aba27e80628022c24eb12a (MD5)<br>Made available in DSpace on 2013-10-18T18:15:09Z (GMT). No. of bitstreams: 1 Murilo F. Castro. Avaliação da atividade,,, 2012.pdf: 1468986 bytes, checksum: 7b9241cb49aba27e80628022c24eb12a (MD5) Previous issue date: 2012<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil<br>A doença de Chagas (DC) é considerada um agravo ainda neglig

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NASCIMENTO, Wilson Silva do. "Síntese de 1,2,3- triazóis ligados a 1,4- naftoquinona via reação de cicloadição 1,3- dipolar." Universidade Federal Rural de Pernambuco, 2011. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6380.

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Submitted by (lucia.rodrigues@ufrpe.br) on 2017-02-15T15:40:19Z No. of bitstreams: 1 Wilson Silva do Nascimento.pdf: 1102619 bytes, checksum: f3fd4580e9425c165601806a91092eda (MD5)<br>Made available in DSpace on 2017-02-15T15:40:19Z (GMT). No. of bitstreams: 1 Wilson Silva do Nascimento.pdf: 1102619 bytes, checksum: f3fd4580e9425c165601806a91092eda (MD5) Previous issue date: 2011-02-15<br>In the present study was performed the synthesis of a new series of 1,2,3- triazole derivative 1,4-disubstituted naphthoquinone group containing the position of a heterocyclic ring from the reaction of 1,

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Gabriel, Gabriela Hadler. "Propriedades citotóxicas da Beta-Lapachona em células de osteossarcoma in vitro." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/7150.

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Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2017-04-13T17:22:48Z No. of bitstreams: 2 Dissertação - Gabriela Hadler Gabriel - 2017.pdf: 1069284 bytes, checksum: 7c190e383bf6069f54d2eff26158427f (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-04-17T11:13:33Z (GMT) No. of bitstreams: 2 Dissertação - Gabriela Hadler Gabriel - 2017.pdf: 1069284 bytes, checksum: 7c190e383bf6069f54d2eff26158427f (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<b

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SILVA, Mauro Gomes da. "Síntese de derivados 2,3-diino-1,4-naftoquinonas usando a reação de Sonogashira e avaliação da atividade citotóxica." Universidade Federal Rural de Pernambuco, 2012. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6364.

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Submitted by (lucia.rodrigues@ufrpe.br) on 2017-02-15T13:39:52Z No. of bitstreams: 1 Mauro Gomes da Silva.pdf: 2235103 bytes, checksum: 2f7922e62d0e9e6cd2bbc309f61aa8f1 (MD5)<br>Made available in DSpace on 2017-02-15T13:39:52Z (GMT). No. of bitstreams: 1 Mauro Gomes da Silva.pdf: 2235103 bytes, checksum: 2f7922e62d0e9e6cd2bbc309f61aa8f1 (MD5) Previous issue date: 2012-03-14<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>In the present study ten 2,3-diyne-1,4-naphthoquinone derivatives were synthesized by Sonogashira coupling reaction between the 2

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Araújo, Morgana Vital de. "Investigação leishmanicida de protótipos de origem natural e sintéticos." Universidade Federal de Alagoas, 2016. http://www.repositorio.ufal.br/handle/riufal/1467.

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Leishmaniasis is among the most neglected diseases in the world. Currently, the drugs available for its treatment are limited and highly toxic, so the search for more effective and safer medicines is necessary. Thus, this paper aims to investigate the leishmanicidal activity of new natural, and synthetic. Two series of new 1,4-naphthoquinone derivatives were synthesized. The series of bis-2-hydroxy-1,4-naphthoquinone substituents exhibited significant activity against Leishmania amazonensis and Leishmania braziliensis promastigotes, six compounds showed good activity without toxic effects agai

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TOMAZ, Alecsandra Ferreira. "Desenvolvimento de membrana de quitosana/1,4 naftoquinona para liberação controlada: curativo para feridas oncológicas." Universidade Federal de Campina Grande, 2017. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/320.

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Submitted by Lucienne Costa (lucienneferreira@ufcg.edu.br) on 2018-03-23T21:32:37Z No. of bitstreams: 1 ALECSANDRA FERREIRA TOMAZ – TESE (PPGEP) 2017.pdf: 2915596 bytes, checksum: 50bc5abc5a322e77e912a5a1a69a3ce7 (MD5)<br>Made available in DSpace on 2018-03-23T21:32:37Z (GMT). No. of bitstreams: 1 ALECSANDRA FERREIRA TOMAZ – TESE (PPGEP) 2017.pdf: 2915596 bytes, checksum: 50bc5abc5a322e77e912a5a1a69a3ce7 (MD5) Previous issue date: 2017-12-15<br>As lesões cutâneas associadas ao câncer de pele apresentam crescente importância na atualidade, visto que este tipo de câncer é o mais incidente

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Brown, Jason David. "A Computational Investigation Into the Development of an Effective Therapeutic Against Organophosphorus Nerve Agent Exposure." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1416836502.

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MELO, Valentina Nascimento e. "Síntese de 2-(1H-1,2,3-triazol)-1,4-naftoquinona de O-glicosídeos 2,3-insaturados com potencial antitumoral." Universidade Federal Rural de Pernambuco, 2015. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6378.

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Submitted by (lucia.rodrigues@ufrpe.br) on 2017-02-15T15:25:59Z No. of bitstreams: 1 Valentina Nascimento e Melo.pdf: 1846879 bytes, checksum: 0f435fbf6eac1935724bc84cb61e7e68 (MD5)<br>Made available in DSpace on 2017-02-15T15:25:59Z (GMT). No. of bitstreams: 1 Valentina Nascimento e Melo.pdf: 1846879 bytes, checksum: 0f435fbf6eac1935724bc84cb61e7e68 (MD5) Previous issue date: 2015-03-16<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>Two strategies were considered for the synth

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Bapela, MJ, N. Lall, JH Isaza-Martinez, T. Regnier, and JJM Meyer. "Variation in the content of naphthoquinones in seeds and seedlings of Euclea natalensis." South African Journal of Botany, 2008. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000789.

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A correlation between plant growth and accumulation of naphthoquinones (shinanolone (1), 7-methyljuglone (2) and diospyrin (3)) was investigated in seeds and seedlings of Euclea natalensis A.DC. In this study, the seeds represented the first stage whereas the second seedling stage was defined as the stage, when the radicles were about 6 cm in length. The lengths of the seedlings at the third, fourth and fifth seedling stages were 9 cm, 12 cm and 16 cm respectively. Plant materials collected from the five seedling stages were separately extracted using chloroform and the naphthoquinones were th

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Gudmundsdóttir, Anna Dóra. "Photochemistry of some naphthoquinols in solid polymer matrices." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27471.

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The main objective of this work was to study how polymer media can modify the photochemical reactivity of dissolved guest molecules. Three tetrahydronaphthoquinols, whose photochemistry is known to be sensitive to the reaction medium, were synthesized for this study. The photochemistry of these compounds consisted of [2 + 2] cycloaddition in solution and hydrogen abstraction-initiated rearrangement in the solid state. Different photopro-ducts from solution and solid state photolysis were interpreted as being due to reaction from different conformers in the different media. 2,3,4aα,6,7,8aα-hex

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Chiwakata, M., la Mare Jo-Anne De, Adrienne Lesley Edkins, and Denzil R. Beukes. "Sarqaquinoic acid and related synthetic naphthoquinones inhibit the function of Hsp90." Georg Thieme Verlag KG, 2016. http://hdl.handle.net/10962/66324.

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publisher version<br>Heat shock protein 90 (Hsp90) is of critical importance in the proper folding of numerous proteins, including those involved in cancer. Consequently, there is significant interest in the discovery and development of Hsp90 inhibitors as anticancer drugs. In this study, we investigated the ability of sargaquinoic acid (SQA) and selected naphthoquinone derivatives to inhibit Hsp90 function. SQA was isolated and purified from Sargassum incisifolium while the naphthoquinones were synthesised via a straightforward sequence incorporating a Diels-Alder reaction between benzoquinon

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Teles, Aila Mirtes. "Contribuição farmacológica à gênese da inflamação neurogênica em vias aéreas de ratos frente a dois poluentes: Partículas eliminadas na exaustão do diesel (PED) e 1,2-naftoquinona (1,2-NQ)." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-24092007-094137/.

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Neste estudo efetuou-se uma análise comparativa da resposta inflamatória e estresse oxidativo produzido pela administração intratraqueal (i.tr.) das PED e/ou 1,2-NQ em vias aéreas de ratos. O efeito destes poluentes sobre a funcionabilidade dos macrófagos foi também avaliado. A injeção i.tr. das PED, numa dose incapaz de causar edema, promoveu efeito aditivo no edema e influxo de leucócitos induzido pela 1,2-NQ nas vias aéreas. O edema foi inibido por antagonistas de taquicininas ou capsaicina, mas o influxo de leucócitos não. O tratamento com estes poluentes aumentou a expressão gênica dos re

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Costa, Arinice de Menezes. "Estudo do mecanismo de aÃÃo citotÃxica de naftoquinonas sintÃticas anÃlogas do lapachol." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11008.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>O lapachol, uma naftoquinona natural, e seus derivados sintÃticos tÃm demonstrado, nos Ãltimos anos, importantes aÃÃes citotÃxicas contra varias linhagens de cÃlulas tumorais, assim como significante atividade antitumoral contra alguns tumores. Assim, o objetivo desse trabalho foi avaliar o mecanismos de aÃÃo citotoxica em cÃlulas HL-60 de duas naftoquinonas sintÃticas anÃlogas do lapachol (compostos 1 e 2). Inicialmente foi investigado a atividade antiprolif

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Meye, Biyogo Alex. "Stratégie radicalaire SRN1/Mn(OAc)3 sur des dérivés naphtoquinoniques à visée pharmacologique." Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4750.

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Ce travail est consacré à la recherche et au développement de nouvelles molécules à viséepharmacologique en série naphtoquinonique en utilisant des réactions par transfert monoélectroniquede type SRN1 et des cyclisations radicalaires oxydatives induites par l'acétate de manganèse(III). Lapremière partie décrit l’étude de la réactivité SRN1 de la 2-(chlorométhyl)-3-méthoxynaphtoquinoneavec divers anions nitronates conduisant à la formation de produits de C-alkylation avec de bonsrendements. Ces derniers ont fait l’objet d’une réaction de réduction-cyclisation permettant la synthèsede nouveaux d

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Meye, Biyogo Alex. "Stratégie radicalaire SRN1/Mn(OAc)3 sur des dérivés naphtoquinoniques à visée pharmacologique." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4750.

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Ce travail est consacré à la recherche et au développement de nouvelles molécules à viséepharmacologique en série naphtoquinonique en utilisant des réactions par transfert monoélectroniquede type SRN1 et des cyclisations radicalaires oxydatives induites par l'acétate de manganèse(III). Lapremière partie décrit l’étude de la réactivité SRN1 de la 2-(chlorométhyl)-3-méthoxynaphtoquinoneavec divers anions nitronates conduisant à la formation de produits de C-alkylation avec de bonsrendements. Ces derniers ont fait l’objet d’une réaction de réduction-cyclisation permettant la synthèsede nouveaux d

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48

Thaver, Veneesha. "Isolation and characterization of the cytotoxicity, intracellular bioactivity and mechanism of antimycobacterial action of Euclea natalensis-derived naphthoquinones." Thesis, University of Pretoria, 2010. http://hdl.handle.net/2263/31311.

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The major cause of HIV-related mortality in Sub-Saharan countries is pulmonary tuberculosis (TB), which is an escalating threat due to the emergence of multidrug resistant (MDR) and extremely multidrug resistant (XDR) TB. There is clearly an urgent requirement for the identification of novel, affordable anti-TB (as well as anti-HIV) drugs. This study was undertaken with the objective of isolating and characterizing the antimycobacterial potential of 3 naphthoquinones, i.e. neodiospyrin, diospyrin and 7- methyljuglone present in the roots of Euclea natalensis. The laboratory research included:

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Bulovas, Arūnas. "Biomimetiniai (metil)naftochinono omega-merkapto darinių savitvarkiai monosluoksniai ant aukso ir sidabro paviršių: elektrocheminiai ir spektroskopiniai redokso virsmų ir struktūros tyrimai." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100204_103017-67369.

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Sintezuotas didelis rinkinys naujų biomimetinių 1,4-naftochinono merkapto darinių, besiskiriančių šoninės grandinės ilgiu ir įterptomis funkcinėmis grupėmis. Jų savitvarkių monosluoksnių ant aukso ir sidabro paviršių struktūra ir redokso virsmai ištirti ciklinės voltamperometrijos ir paviršiaus sustiprintos Ramano spektroskopijos metodais. Ištirta monosluoksnio paviršinės koncentracijos ir kitų parametrų priklausomybė nuo modifikacinių tirpalų koncentracijos. Palyginti mišrūs 1,4-naftochinono darinių ir skirtingų alkantiolių, neturinčių redokso aktyvumo, monosluoksniai.<br>A large set of biomi

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Neta, Maria Adalgiza dos Santos. "Atividade antifÃngica in vitro de compostos naftoquinoidais contra cepas de Candida tropicalis resistentes ao fluconazol." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9561.

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A incidÃncia de infecÃÃes oportunistas causadas por fungos, com destaque para as leveduras do gÃnero Candida vem aumentando substancialmente. Estudos relatam que tem sido observado um notÃvel crescimento de infecÃÃes por espÃcies nÃo albicans (Candida tropicalis, Candida glabrata, Candida parapsilosis e Candida krusei). Isolados clÃnicos resistentes aos azÃlicos, em especial ao fluconazol, sÃo cada vez mais relatados. As naftoquinonas sÃo uma importante classe de molÃculas biologicamente ativas, apresentando atividades antibacteriana, antifÃngica, antiviral, anti-inflamatÃria, antipirÃtica, a

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