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Journal articles on the topic 'Nar'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Wenzek, Felix, Alexander Biallas, and Sabine Müller. "Nicotinamide Riboside: What It Takes to Incorporate It into RNA." Molecules 29, no. 16 (2024): 3788. http://dx.doi.org/10.3390/molecules29163788.

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Nicotinamide is an important functional compound and, in the form of nicotinamide adenine dinucleotide (NAD), is used as a co-factor by protein-based enzymes to catalyze redox reactions. In the context of the RNA world hypothesis, it is therefore reasonable to assume that ancestral ribozymes could have used co-factors such as NAD or its simpler analog nicotinamide riboside (NAR) to catalyze redox reactions. The only described example of such an engineered ribozyme uses a nicotinamide moiety bound to the ribozyme through non-covalent interactions. Covalent attachment of NAR to RNA could be adva

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Moideen, Sanu P., Srinivas Kishore Sistla, Sabu Abdul Hameed Noorjehan, Razal Mohammed Sheriff, and Subina Beegum Samad. "Beyond the horizontal – impact of body position on nasal dynamics: insights from 4-phase positional rhinomanometry." Romanian Journal of Rhinology 15, no. 57 (2025): 32–39. https://doi.org/10.2478/rjr-2025-0006.

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Abstract BACKGROUND. Positive posture reaction is a common concern in obstructive sleep apnea (OSA) patients, which affects both their sleep quality and overall health-related quality of life. Rhinomanometry has been used as a functional test to assess nasal airway resistance (NAR) and measure nasal airflow (NAF). OBJECTIVE. We conducted this study using 4-phase positional rhinomanometry (4PPR) to investigate potential correlations between NAR and NAF when comparing the sitting and supine positions through the use of 4PPR. MATERIAL AND METHODS. This cross-sectional study involved a consecutive

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3

Shabalin, Konstantin, Kirill Nerinovski, Alexander Yakimov, et al. "NAD Metabolome Analysis in Human Cells Using 1H NMR Spectroscopy." International Journal of Molecular Sciences 19, no. 12 (2018): 3906. http://dx.doi.org/10.3390/ijms19123906.

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Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form, NADP, are the major coenzymes of redox reactions in central metabolic pathways. Nicotinamide adenine dinucleotide is also used to generate second messengers, such as cyclic ADP-ribose, and serves as substrate for protein modifications including ADP-ribosylation and protein deacetylation by sirtuins. The regulation of these metabolic and signaling processes depends on NAD availability. Generally, human cells accomplish their NAD supply through biosynthesis using different forms of vitamin B3: Nicotinamide (Nam) and nicotinic a

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4

محمد, عمران على. "تأثير التلقيح ببكتيريا العقد الجذرية على نمو الأكاسيا ساليجنا ( Acacia saligna ) وتكوين العقد الجذرية تحت تأثير الإجهاد الملحي". Al-Mukhtar Journal of Sciences 33, № 3 (2018): 256–62. http://dx.doi.org/10.54172/mjsc.v33i3.247.

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أجريت التجربة في الصوبة لدراسة تأثير التلقيح بسلالات مختلفة من بكتيريا العقد الجذرية المعزولة من جذور شتلات الاكاسيا ساليجنا Acacia saligna) ) على تكوين العقد الجذرية وتثبيت النيتروجين ونمو نباتات الاكاسيا ساليجنا تحت تأثير مستويات مختلفة من الملوحة ( dsm-1 4 ، 5 ، 8 ، 10 ) على التوالي والتلقيح بالسلالات التالية (NA1, NA2 , NA3 , NA4) ومعاملة ( NA0 ) بدون تلقيح , وبثلاث مكررات لكل معاملة نفذت التجربة في أصص باستخدام تربة جيرية من منطقة الوسيطة وتم دراسة تأثير المستويات المختلفة للملوحة على نمو نباتات الاكاسيا ساليجنا وتكوين العقد الجذرية وتثبيت النيتروجين , حيث أظهرت النتائج أن التلقيح بالسلال

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Zou, Linfeng, Bing Liang, YuanZhen Gao, et al. "Nicotinic Acid Riboside Regulates Nrf-2/P62-Related Oxidative Stress and Autophagy to Attenuate Doxorubicin-Induced Cardiomyocyte Injury." BioMed Research International 2022 (February 22, 2022): 1–14. http://dx.doi.org/10.1155/2022/6293329.

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Doxorubicin (Dox) is an effective chemotherapeutic drug for the treatment of various cancers. Due to its potential fatal cardiotoxic side effects, the clinical application is often limited. Dexrazoxane (Dex) is the only drug approved by the Food and Drug Administration (FDA) for the prevention of Dox-induced cardiotoxicity but has side effects. Thus, more protective strategies should be explored. If NAD+ plays a role in maintaining heart function, its precursor prospectively alleviates Dox-induced cellular injury. Here, we studied the protective effects of nicotinic acid riboside (NAR) on Dox-

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6

Bjerck, Hein B. "NAR Backstage." Norwegian Archaeological Review 39, no. 2 (2006): 105–9. http://dx.doi.org/10.1080/00293650601135385.

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7

Ergülen, Haydar, and Murat Nemet-Nejat. "Pomegranate (Nar)." Translation Review 68, no. 1 (2004): 81. http://dx.doi.org/10.1080/07374836.2004.10523889.

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8

Zhou, Meijia, Jinlong Wang, Haibo Hu, et al. "Simulated Nitric Acid Rain Aggravated the C and P Limits of Forest Soil Microorganisms." Forests 14, no. 5 (2023): 1044. http://dx.doi.org/10.3390/f14051044.

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With the comprehensive emissions of fossil fuel combustion and transportation waste gas, the concentrations of nitrogen oxides (NOX) in the environmental atmosphere increase significantly, leading to nitric acid rain (NAR) pollution. However, the effects of NAR on soil enzyme activities and soil microbial metabolism are unclear. In this study, the Quercus acutissima Carruth. forest in the Yangtze River Delta of China was selected as the experimental subject, and was exposed to the simulated spraying of NAR with pH values of 2.5, 3.5, and 4.5 to study the response of the forest soil enzyme acti

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9

Shelly and Minakshi Sharma. "Nitrate Reductase Nanoparticles: Synthesis and Characterization." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 4583–89. http://dx.doi.org/10.26452/ijrps.v11i3.2740.

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Nanoparticles of enzyme Nitrate reductase (NaR) a soluble homodimer enzyme of ∼100 kDa polypeptide with cofactors – FAD, heme-molybdopterin (Mo-MPT) and electron donor NAD(P)H, catalyses the reduction of nitrate to nitrite has been synthesised. Nanoparticles of Nitrate reductase enzyme have been prepared by chemical desolvation method including glutaraldehyde cross-linking to form the nanoaggregate. Characterisation of NaR nanoparticles has been made by Transmission Electron Microscopy (TEM), UV-Visible Spectroscopy and by electrochemical Impedance Spectroscopic Study (EIS). TEM study revealed

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10

Cantone, Elena, Aikaterini Detoraki, and Eugenio De Corso. "Local Allergic Rhinitis: A Different Rhinitis Endotype? Literature Overview." Applied Sciences 12, no. 21 (2022): 11141. http://dx.doi.org/10.3390/app122111141.

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Chronic rhinitis (CR) is commonly divided into allergic rhinitis (AR) and nonallergic rhinitis (NAR). AR is triggered by the immunoglobulin E (IgE)-mediated response to allergens, whereas NAR is characterized by the absence of allergic sensitization. Previous studies have demonstrated the presence of local IgE in the nasal mucosa of patients suffering from typical allergic rhinitis (AR) symptoms but without a history of atopy and a positive response to a nasal allergen challenge (NAC). This condition was recently defined as local allergic rhinitis (LAR), which is supposed to be a different CR

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11

van Hoogstraten, L. M. C., E. J. van Gennep, L. A. L. M. Kiemeney, et al. "Occult lymph node metastases in patients without residual muscle-invasive bladder cancer at radical cystectomy with or without neoadjuvant chemotherapy: a nationwide study of 5417 patients." World Journal of Urology 40, no. 1 (2021): 111–18. http://dx.doi.org/10.1007/s00345-021-03839-7.

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Abstract Purpose Little is known about the prevalence of occult lymph node metastases (LNM) in muscle-invasive bladder cancer (MIBC) patients with pathological downstaging of the primary tumor. We aimed to estimate the prevalence of occult LNM in patients without residual MIBC at radical cystectomy (RC) with or without neoadjuvant chemotherapy (NAC) or neoadjuvant radiotherapy (NAR), and to assess overall survival (OS). Methods Patients with cT2-T4aN0M0 urothelial MIBC who underwent RC plus pelvic lymph node dissection (PLND) with curative intent between January 1995–December 2013 (retrospecti

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12

Kropotov, Andrey, Veronika Kulikova, Kirill Nerinovski, et al. "Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells." International Journal of Molecular Sciences 22, no. 3 (2021): 1391. http://dx.doi.org/10.3390/ijms22031391.

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Nicotinamide riboside (NR), a new form of vitamin B3, is an effective precursor of nicotinamide adenine dinucleotide (NAD+) in human and animal cells. The introduction of NR into the body effectively increases the level of intracellular NAD+ and thereby restores physiological functions that are weakened or lost in experimental models of aging and various pathologies. Despite the active use of NR in applied biomedicine, the mechanism of its transport into mammalian cells is currently not understood. In this study, we used overexpression of proteins in HEK293 cells, and metabolite detection by N

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13

Jang, Nam, Junekyu Kim, Hyun Woo Shin, and Sang Woo Suk. "Long V-Y advancement technique for large nipple reconstruction in Asian women." Archives of Plastic Surgery 48, no. 1 (2021): 44–48. http://dx.doi.org/10.5999/aps.2020.00724.

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Previously reported nipple-areolar complex reconstruction (NAR) methods involve multiple incisions and wide skin redraping, which increase retraction forces and heighten the risk of nipple-areolar complex (NAC) flattening. We introduce a NAR method using the long V-Y advancement technique that can overcome these disadvantages. A V-shaped flap is designed with the width of the flap base 4–5 mm larger than the diameter of the normal nipple. The flap length is designed to be at least 2.5 times its width. Dissection is performed to the top of the artificial dermal matrix or muscle layer. The nippl

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14

Xu, Dan, Gui-Qiu Zhang, Ting-Ting Zhang, Bo Jin, and Chen Ma. "Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MS/MS." Journal of Analytical Methods in Chemistry 2020 (April 1, 2020): 1–10. http://dx.doi.org/10.1155/2020/8364218.

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Naringenin (NAR), 4′,5,7-trihydroxydihydroflavone, has a wide range of pharmacological activities but shows poor water solubility and low bioavailability. The pharmacokinetics and bioavailability of naringenin-nicotinamide cocrystal (NAR-NCT), which offers improved solubility, were evaluated in this study. Rats were orally administered NAR, a physical mixture of naringenin and nicotinamide (NAR + NCT), and NAR-NCT. The relative bioavailability of NAR-NCT was 175.09% of NAR, Cmax was 8.43 and 2.06 times of NAR and NAR + NCT, respectively, Tmax was advanced from 0.49 h to 0.09 h, CL was decrease

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15

de Corso, E., M. Battista, M. Pandolfini, et al. "Role of inflammation in non-allergic rhinitis." Rhinology journal 52, no. 2 (2014): 142–49. http://dx.doi.org/10.4193/rhino13.102.

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Objective: To investigate the role of inflammation in non-allergic rhinitis (NAR) patients in a large series to establish the prevalence of different NAR-subtypes, clinical features and the role of nasal cytology in the diagnostic algorithm. Methodology: Patients were selected out of 3650 individuals who spontaneously presented at our institution. We consecutively enrolled 519 NAR-patients in an analytical cross-sectional study between November 2007 and June 2013 (level of evidence: 3b). All patients underwent rhinological evaluation including symptoms questionnaire, endoscopy, CT scan, allerg

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16

Wang, H., and Y. Zhang. "POS0433 POTENTIAL THERAPEUTIC EFFECTS OF NARINGENIN ON RA THROUGH SUPPRESSING P2X7R/NLRP3 MEDIATED PYROPTOSIS BY TARGETING ESR." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 471.1–471. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3491.

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BackgroundNaringenin (NAR), a partial agonist on estrogen receptor, is naturally occurring flavonoids in grapes and grapefruits. We previously reported that NAR in patients with Rheumatoid arthritis (RA) have changed significantly [1]. However, the role and mechanism of action of NAR in RA remain unclear.ObjectivesThis study aimed to determine the roles and mechanisms of NAR on RA and provides a basis for NAR to become a potential therapeutic agent for RA.MethodsThis study employed bovine type II collagen-induced arthritis (CIA) rats, in vitro mononuclear cells (MNCs) as models to explore the

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17

Kosta, Jiří. "Československo-nemecké hospodárske vzťahy (vývoj - problémy - perspektívy)." Czech Journal of International Relations 27, no. 3 (1992): 29–40. http://dx.doi.org/10.32422/cjir.1362.

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Jiří Kosta, nar. 1912, absolvent Vysoké školy obchodní, v letech 1962-1969 vědecký pracovník Ekonomického ústavu ČSAV. Od roku 1969 žije v SRN. Emeritní profesor J. W. Goethe Universität ve Frankfurtu nad Mohanem. Zabývá se národním hospodářstvím a politologií.

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18

Cordenonsi, Leticia Malgarim, Rafaela Martins Sponchiado, Jardel Rodrigo Bandeira, Roberto Chris Vianna Santos, Renata Platchek Raffin, and Elfrides Eva Scherman Schapoval. "Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studies." Drug Analytical Research 4, no. 2 (2020): 64–71. http://dx.doi.org/10.22456/2527-2616.108783.

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Naringin (NAR) and naringenin (NGE) are flavonoids with important effects, such as antioxidant, nephroprotective and anti-inflammatory action. However, factors such as poor solubility and oral bioavailability, gastrointestinal instability and extensive first pass metabolism lead to limited deliverability. As far as we know, there are no papers describing the use of combination of NAR and NGE in nanoparticles. This paper describes the development and characterization of new nanoparticles containing NAR and NGE (NAR-NGE-NPs) which were prepared by nanoprecipitation using ethanol or mixture of so

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Md, Shadab, Nabil A. Alhakamy, Hibah M. Aldawsari, et al. "Formulation Design, Statistical Optimization, and In Vitro Evaluation of a Naringenin Nanoemulsion to Enhance Apoptotic Activity in A549 Lung Cancer Cells." Pharmaceuticals 13, no. 7 (2020): 152. http://dx.doi.org/10.3390/ph13070152.

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Naringenin (NAR), a flavonoid mainly found in citrus and grapefruits, has proven anti-cancer activities. However, the poor water solubility and low bioavailability of NAR limits its use as a therapeutic agent. The aim of this study was to develop and optimize stable naringenin nanoemulsions (NAR-NE) using a Box–Behnken experimental design to obtain a formulation with a higher efficiency. Anticancer activity of optimized NAR-NE was evaluated in A549 lung cancer cells using cell viability, flow-cytometric assays, and enzyme-linked immunosorbent assay. The stabilized nanoemulsion, which showed a

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Salunkhe, Jitendra Dattatray, Indra Neel Pulidindi, Vikas Sambhaji Patil, and Satish Vitthal Patil. "Neurospora sp. Mediated Synthesis of Naringenin for the Production of Bioactive Nanomaterials." Bioengineering 11, no. 5 (2024): 510. http://dx.doi.org/10.3390/bioengineering11050510.

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The application of Neurospora sp., a fungus that commonly thrives on complex agricultural and plant wastes, has proven successful in utilizing citrus peel waste as a source of naringin. A UV-Vis spectrophotometric method proved the biotransformation of naringin, with an absorption maximum (λmax) observed at 310 nm for the biotransformed product, naringenin (NAR). Further verification of the conversion of naringin was provided through thin layer chromatography (TLC). The Neurospora crassa mediated biotransformation of naringin to NAR was utilized for the rapid (within 5 min) synthesis of silver

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Islam, Saiful, and Nargis Jahan. "Growth analysis of wheat var. BARI gom-26 as affected by foliar spray of NAA at different nitrogen fertilizer levels." Dhaka University Journal of Biological Sciences 25, no. 2 (2016): 131–38. http://dx.doi.org/10.3329/dujbs.v25i2.46335.

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Leaf area index (LAI), crop growth rate (CGR), relative growth rate (RGR), net assimilation rate (NAR) and leaf area duration (LAD) of a variety of wheat (Triticum aestivum L.) were studied with three concentrations (0, 25 and 50 ppm) of naphthalene acetic acid (NAA) and four levels (0, 50, 75 and 100 %) of Nfertilizer in a field experiment during 2014 - 2015. Results showed that LAI and LAD at all stages of growth increased from control and their peak values were recorded mostly from 25 ppm NAA in combination with 75 % N-fertilizer and 50 ppm NAA in combination with 50% N-fertilizer. RGR was

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Carswell, Savion, Tanzim Mridha, Cynthia E. Francis, Shashidharamurthy Taval, and Srujana Rayalam. "Osteogenic Effects of Naringenin Are Mediated Through the Activation of AMPK Pathway." Current Developments in Nutrition 4, Supplement_2 (2020): 12. http://dx.doi.org/10.1093/cdn/nzaa040_012.

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Abstract Objectives Bone marrow mesenchymal stem cells are the precursor cells for adipocytes and osteoblasts. The accumulation of adipocytes in bone marrow at the expense of osteoblastogenesis is a major factor contributing to age-related bone loss. Grapefruit flavonoid naringenin (NAR) was shown to promote osteogenesis but the mechanism behind these effects is not clear. In this study, we propose to demonstrate that the osteogenic effects of NAR are mediated through the activation of adenosine monophosphate-activated kinase (AMPK) pathway. Methods MC3T3-E1 pre-osteoblast cells were cultured

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Yüksel, Cemil, Mutlu Doğan, Serdar Çulcu, and Lütfi Doğan. "Abstract P4-06-05: Can we adapt neoadjuvant rectal (NAR) score besides sytemic immun inflammation index (SII) and prognostic nutritional index (PNI) as prognostic factors to locally advanced breast cancer?" Cancer Research 82, no. 4_Supplement (2022): P4–06–05—P4–06–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-06-05.

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Abstract Introduction. Neoadjuvant treatment (NAT) is standard in locally advanced breast (LABC) & rectal cancer (LARC). Neoadjuvant rectal (NAR) score is a novel prognostic factor in LARC. Therefore, NAR score may also have prognostic value in LABC. We aimed to adapt NAR score with inflammatory indices such as systemic immune inflammation index (SII) and prognostic nutritional index (PNI) as prognostic factors in LABC. Material and Methods. 187 LABC patients who had NAT at our center were evaluated retrospectively. The nomogram by Valentini for NAR score was used. Cutoff values for NAR, S

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Chen, Xuan, Yiming Wang, Hui Wei, and Jiaen Zhang. "Nitric Acid Rain Decreases Soil Bacterial Diversity and Alters Bacterial Community Structure in Farmland Soils." Agronomy 14, no. 5 (2024): 971. http://dx.doi.org/10.3390/agronomy14050971.

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Being regarded as one of the environmental problems endangering biodiversity and ecosystem health, acid rain has attracted wide attention. Here, we studied the effects of nitric acid rain (NAR) on the structure and diversity of microbial communities in agricultural soils by laboratory incubation experiments and greenhouse experiments. Our results indicated that NAR had an inhibitory effect on soil microorganisms, showing a significant reduction in the Chao1 index and Shannon index of soil bacteria. Proteobacteria, Acidobacteriota, Actinobacteriota, and Chloroflexi were the dominant bacterial p

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Liu, Hui-wen, Chadwick B. Smith, Mark S. Schmidt, et al. "Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration." Proceedings of the National Academy of Sciences 115, no. 42 (2018): 10654–59. http://dx.doi.org/10.1073/pnas.1809392115.

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Axon degeneration, a hallmark of chemotherapy-induced peripheral neuropathy (CIPN), is thought to be caused by a loss of the essential metabolite nicotinamide adenine dinucleotide (NAD+) via the prodegenerative protein SARM1. Some studies challenge this notion, however, and suggest that an aberrant increase in a direct precursor of NAD+, nicotinamide mononucleotide (NMN), rather than loss of NAD+, is responsible. In support of this idea, blocking NMN accumulation in neurons by expressing a bacterial NMN deamidase protected axons from degeneration. We hypothesized that protection could similarl

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Fujihara, C. K., D. M. Limongi, R. Falzone, M. S. Graudenz, and R. Zatz. "Pathogenesis of glomerular sclerosis in subtotally nephrectomized analbuminemic rats." American Journal of Physiology-Renal Physiology 261, no. 2 (1991): F256—F264. http://dx.doi.org/10.1152/ajprenal.1991.261.2.f256.

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The Nagase analbuminemic rat (NAR), a mutant of the Sprague-Dawley (SD) strain, exhibits persistent hypercholesterolemia, thrombocytosis, and enhanced platelet aggregation, abnormalities possibly involved in the genesis of glomerular sclerosis (GS). Previous observations suggest that these rats never develop aging GS. We studied the development of GS in NAR after 5/6 nephrectomy (Nx). Fifteen days after Nx, marked glomerular hypertension was observed in NAR, compared with only mild elevations in SD rats. Glomerular hypertrophy was more marked in SD rats than in NAR. Enalapril normalized glomer

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MacDonald, Gaye E., Rajasekaran R. Lada, Claude D. Caldwell, Chibuike C. Udenigwe, and Mason T. MacDonald. "Linking Changes in Fatty Acid Composition to Postharvest Needle Abscission Resistance in Balsam Fir Trees." Forests 13, no. 5 (2022): 800. http://dx.doi.org/10.3390/f13050800.

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Balsam fir needle retention and fatty acid profile changes due to cold acclimation throughout autumn, but little is known about the relationship between these two phenomena. The objective was to examine differences in FAs in contrasting needle abscission resistant balsam fir genotypes throughout autumn and early winter. Branches from genotypes with low and high needle abscission resistance (NAR) were collected from September to January and analyzed for FA composition. High NAR genotypes retained needles 120–130% longer than low NAR genotypes and NAR increased through autumn in both genotypes.

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Fujihara, C. K., D. M. Limongi, H. C. De Oliveira, and R. Zatz. "Absence of focal glomerulosclerosis in aging analbuminemic rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 262, no. 6 (1992): R947—R954. http://dx.doi.org/10.1152/ajpregu.1992.262.6.r947.

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The Nagase analbuminemic rat (NAR), a mutant of the Sprague-Dawley (SD) strain, exhibits high levels of plasma cholesterol (Chol), thrombocytosis, and enhanced platelet aggregability, which might promote glomerulosclerosis (GS). To determine whether NAR are more susceptible than SD rats to aging GS, young (3-mo-old) and aging (18-mo-old) SD rats and NAR were studied. In young NAR, glomerular pressure and glomerular volume were lower, whereas total and high-density lipoprotein plasma Chol levels were higher than in young SD rats. Aging SD rats developed glomerular hypertension and hypertrophy.

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Joles, J. A., N. Willekes-Koolschijn, B. Braam, W. Kortlandt, H. A. Koomans, and E. J. Dorhout Mees. "Colloid osmotic pressure in young analbuminemic rats." American Journal of Physiology-Renal Physiology 257, no. 1 (1989): F23—F28. http://dx.doi.org/10.1152/ajprenal.1989.257.1.f23.

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Colloid osmotic pressure (COP) was measured in plasma and interstitial fluid (subcutaneous wick) from 8 to 75 days of age in Nagase analbuminemic rats (NAR) and control Sprague-Dawley rats (SDR). In all animals plasma COP (approximately 10 mmHg at 8 days of age) increased during growth. In the female NAR the rise in nonalbumin proteins was so large that at 75 days the plasma COP was not lower than in the SDR; whereas in male NAR a difference of approximately 4 mmHg remained. Interstitial COP increased with aging in the SDR, but not in the NAR. This resulted in equal transcapillary COP gradient

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García-Trejo, José J., Sharon Rojas-Alcantar, Monserrat Alonso-Vargas, et al. "A New Real-Time Simple Method to Measure the Endogenous Nitrate Reductase Activity (Nar) in Paracoccus denitrificans and Other Denitrifying Bacteria." International Journal of Molecular Sciences 25, no. 18 (2024): 9770. http://dx.doi.org/10.3390/ijms25189770.

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The transmembrane nitrate reductase (Nar) is the first enzyme in the dissimilatory alternate anaerobic nitrate respiratory chain in denitrifying bacteria. To date, there has been no real-time method to determine its specific activity embedded in its native membrane; here, we describe such a new method, which is useful with the inside-out membranes of Paracoccus denitrificans and other denitrifying bacteria. This new method takes advantage of the native coupling of the endogenous NADH dehydrogenase or Complex I with the reduction of nitrate by Nar through the quinone pool of the inner membranes

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Galluzzo, Paola, Paolo Ascenzi, Pamela Bulzomi та Maria Marino. "The Nutritional Flavanone Naringenin Triggers Antiestrogenic Effects by Regulating Estrogen Receptor α-Palmitoylation". Endocrinology 149, № 5 (2008): 2567–75. http://dx.doi.org/10.1210/en.2007-1173.

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Naringenin (Nar) is a component of fruits and vegetables associated with healthful benefits, such as in osteoporosis, cancer, and cardiovascular diseases. These protective effects have been linked with Nar antiestrogenic as well as estrogenic activities. Previous studies indicate that Nar impaired estrogen receptor (ER) α signaling by interfering with ERα-mediated activation of ERK and phosphoinositide 3-kinase signaling pathways in the absence of effects at the transcriptional level. The present studies evaluated the hypothesis that these Nar antagonistic effects occur at the level of the pla

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Pallottini, Valentina, Marco Segatto, Filippo Acconcia, Marco Fiocchetti та Maria Marino. "Mechanism Underlying Naringenin Hypocholesterolemic Effects: Involvement of Estrogen Receptor α Subtype". International Journal of Molecular Sciences 23, № 24 (2022): 15809. http://dx.doi.org/10.3390/ijms232415809.

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Naringenin (Nar) is one of major citrus flavonoids predominantly found in grapefruit and orange. In vivo studies have demonstrated Nar potential as a normolipidemic agent capable to reduce circulating cholesterol in hypercholesterolemic rabbits, rats, and patients, suggesting a new role for this molecule in cardiovascular disease prevention. Although Nar cholesterol-lowering effects are known, the underlying mechanisms have not yet been elucidated. Interestingly, Nar binds to the estrogen receptors (ERs), modulating both transcriptional and membrane-initiating signals. Although estrogen and ER

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Fuster, Marta G., Guzmán Carissimi, Mercedes G. Montalbán, and Gloria Víllora. "Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles." Nanomaterials 10, no. 4 (2020): 718. http://dx.doi.org/10.3390/nano10040718.

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Naringenin (NAR), a flavonoid present in a variety of fruits, vegetables and herbs, exhibits a wide range of pharmacological effects, including anticancer activity. Nevertheless, its application in cancer therapy is limited due to its low bioavailability at the tumour site because of its poor solubility in water and slow dissolution rate. To improve the therapeutic efficacy of NAR, emergent research is looking into using nanocarriers. Silk fibroin (SF), from the Bombyx mori silkworm, is a biocompatible and biodegradable polymer with excellent mechanical properties and an amphiphilic chemistry

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Shin, Youngshin, Nosratola D. Vaziri, Nel Willekes, Choong H. Kim та Jaap A. Joles. "Effects of gender on hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and LDL receptor in hereditary analbuminemia". American Journal of Physiology-Endocrinology and Metabolism 289, № 6 (2005): E993—E998. http://dx.doi.org/10.1152/ajpendo.00037.2005.

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Hypoalbuminemia is accompanied by hypercholesterolemia in both nephrotic syndrome and hereditary analbuminemia. Hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats (NAR). The sex difference in plasma cholesterol diminishes after ovariectomy (OVX) and reappears after estrogen replacement in the NAR. The molecular mechanism responsible for the sex difference in severity of hypercholesterolemia in NAR is not known and was investigated here. To this end, hepatic hydroxylmethylglutaryl (HMG)-CoA reductase, cholesterol 7α-hydroxylase, and LDL receptor were de

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Zhang, Yue, Baoping Qu, Gaofeng Qin, et al. "Development of a sensitive and reliable enzyme-linked immunosorbent assay for detecting naringin in human saliva." Analytical Methods 8, no. 5 (2016): 987–94. http://dx.doi.org/10.1039/c5ay02962g.

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Roshankhah, Shiva, Amir Abdolmaleki, and Mohammad Reza Salahshoor. "Reduction of Renal Ischemia-Reperfusion-Induced Liver Side Effects in Rats through Antioxidative Properties of Narigenin." Journal of Advances in Medical and Biomedical Research 29, no. 132 (2020): 46–53. https://doi.org/10.30699/jambs.29.132.46.

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<strong> Background & Objective:</strong>  Pathophysiology of Ischemia/Reperfusion (Isc/R) can cause renal and hepatic damages. Naringenin (NAR) is a flavonoid with potent antioxidant properties. In the present study, the effects of NAR on the liver after the renal Isc/R procedure were investigated. <strong> Materials & Methods: </strong> Sixty-four Wistar rats were divided into eight groups. The animals in the control group received dimethyl sulfoxide (DMSO). Group 2 as the Isc/R group went under the Isc/R procedure. Groups 3, 4, and 5 as the NAR groups r

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Jin, Hua, Yue Zhao, Yinlian Yao, et al. "Intratracheal Administration of Stem Cell Membrane-Cloaked Naringin-Loaded Biomimetic Nanoparticles Promotes Resolution of Acute Lung Injury." Antioxidants 13, no. 3 (2024): 282. http://dx.doi.org/10.3390/antiox13030282.

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Cytokine storm and ROS overproduction in the lung always lead to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in a very short time. Effectively controlling cytokine storm release syndrome (CRS) and scavenging ROS are key to the prevention and treatment of ALI/ARDS. In this work, the naringin nanoparticles (Nar-NPs) were prepared by the emulsification and evaporation method; then, the mesenchymal stem cell membranes (CMs) were extracted and coated onto the surface of the Nar-NPs through the hand extrusion method to obtain the biomimetic CM@Nar-NPs. In vitro, the CM@Nar

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Md, Shadab, Nabil A. Alhakamy, Hibah M. Aldawsari, and Hani Zakaria Asfour. "Neuroprotective and Antioxidant Effect of Naringenin-Loaded Nanoparticles for Nose-to-Brain Delivery." Brain Sciences 9, no. 10 (2019): 275. http://dx.doi.org/10.3390/brainsci9100275.

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Parkinson’s disease (PD) is a neurodegenerative disorder resulting in a decreased nigrostriatal availability of dopamine. Oxidative stress is one factor contributing to PD. Naringenin (NAR), a flavonoid, is a potent antioxidant shown to be beneficial in experimental PD. The clinical development of NAR has been hampered due to its low bioavailability resulting from gastrointestinal degradation, inefficient permeability, and low aqueous solubility. The objective of the present research was to formulate and characterize naringenin-loaded chitosan nanoparticles (NAR NPs) for nose-to-brain delivery

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Devillier, P., JF Dessanges, F. Rakotosihanaka, et al. "Nasal response to substance P and methacholine in subjects with and without allergic rhinitis." European Respiratory Journal 1, no. 4 (1988): 356–61. http://dx.doi.org/10.1183/09031936.93.01040356.

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We compared the rise in nasal airway resistance (NAR) provoked by topical application of substance P (SP) and of methacholine (MCH) in seventeen patients suffering from rhinitis and fourteen control subjects. Challenges with SP or MCH were separated by a week or more. NAR was measured by posterior rhinomanometry before and 10 min after intranasal administration of SP (10-40 nmol) or MCH (3-12 mumol). The two groups of subjects had similar baseline levels of NAR and similar small responses to buffered saline. Substance P but not MCH provoked cutaneous flushing in all subjects. Both SP and MCH p

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Olatunde, Abimbola Modupe, Kehinde Gabriel Obiyenwa, Tofunmi Emmanuel Oladuji, et al. "Molecular modeling and pharmacokinetics studies of sulfamidophosphonate derivatives as potential candidate against Staphylococcus aureus." Ecletica Quimica 50 (June 26, 2025). https://doi.org/10.26850/1678-4618.eq.v50.2025.e1594.

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In silico methods were used in this paper to assess the anti-bacterial activity of Sulfamidophosphonate derivatives against Staphylococcus aureus proteins (1XSD and 4WK3) using molecular docking and ADMET analysis. The results showed that binding affinity (ΔG kJ/mol) ranged from –4.1(NAM) to –7.1 kJ/mol (NAL) for 1XSD, and –5.0 (NAE) to –6.7 kJ/mol (NAM) for 4WK3. Therefore, compounds NAH, NAL, NAN, NAI, NAJ, NAK, 5AD and NAM could be more desirable as inhibitors than Penicillin (–6.0 kJ/mol for 1XSD and –5.4 kJ/mol for 4WK3) in the treatment of Staphylococcus aureus; but ADMET profile reveale

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Stewart, Deborah L., Gregory A. Harshfield, Yanbin Dong, Ryan A. Harris, Gaston Kapuku, and Clarence E. Grim. "Abstract 523: Differences in Sodium and Potassium Regulation during Mental Stress in Normotensive Youths." Hypertension 62, suppl_1 (2013). http://dx.doi.org/10.1161/hyp.62.suppl_1.a523.

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Background: In Dahl salt sensitive rats, the “air puff stress” increases blood pressure (BP) and is associated with acute renal sodium (Na) retention. This study revealed increased dietary potassium (K) may abolish stress induced Na retention. Our human studies have shown the mental stress (MS) of playing a video game increases BP in youths, but the effect on Na excretion is bimodal. Retainers (NaR), retain Na with MS while excreters (NaE), excrete Na during MS. A greater increase in BP with a prolonged effect is seen in NaR. This stress induced NaR phenomena can be abolished by Ang II blockag

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Schrock, Richard Royce, Milan Maji, René Riedel, Matthew Conley, and Veronica Carta. "Syntheses of Tungsten Imido Cyclohexylidene Complexes Using Perfluoro‐t‐butanol or Hexafluoro‐t‐butanol as Acids." Angewandte Chemie, August 13, 2024. http://dx.doi.org/10.1002/ange.202410923.

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The fluorinated alcohols, (CF3)3COH (RF9OH) and (CF3)2MeCOH (RF6OH), react with W(NR)2Cy2 (Cy = Cyclohexyl; R = 2,6‐diisopropylphenyl or 1‐adamantyl) in C6D6 at 55°C to give cyclohexylidene complexes. Traditional routes to terminal alkylidene complexes (neopentylidene or neophylidene) have used either triflic acid or HCl (rarely), but relatively weak fluorinated acids are sufficient and active bisalkoxide catalysts are therefore prepared directly. An ahydrogen abstraction reaction to give a cyclohexylidene complex from a biscyclohexyl appears to be as facile as ahydrogen abstraction to give a

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Schrock, Richard Royce, Milan Maji, René Riedel, Matthew Conley, and Veronica Carta. "Syntheses of Tungsten Imido Cyclohexylidene Complexes Using Perfluoro‐t‐butanol or Hexafluoro‐t‐butanol as Acids." Angewandte Chemie International Edition, August 13, 2024. http://dx.doi.org/10.1002/anie.202410923.

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The fluorinated alcohols, (CF3)3COH (RF9OH) and (CF3)2MeCOH (RF6OH), react with W(NR)2Cy2 (Cy = Cyclohexyl; R = 2,6‐diisopropylphenyl or 1‐adamantyl) in C6D6 at 55°C to give cyclohexylidene complexes. Traditional routes to terminal alkylidene complexes (neopentylidene or neophylidene) have used either triflic acid or HCl (rarely), but relatively weak fluorinated acids are sufficient and active bisalkoxide catalysts are therefore prepared directly. An ahydrogen abstraction reaction to give a cyclohexylidene complex from a biscyclohexyl appears to be as facile as ahydrogen abstraction to give a

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Nomura, Miyuki, Mai Ohuchi, Yoshimi Sakamoto, et al. "Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma." Nature Communications 14, no. 1 (2023). http://dx.doi.org/10.1038/s41467-023-43630-3.

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AbstractNicotinamide phosphoribosyltransferase (NAMPT) plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi, and that NAMPTi therapy against those cancers is enhanced by dietary modification. Neuroendocrine differentiation of tumor cells is associated with down-regulation of genes relevant to quinolinate phosphoribosyltransferase-dependent de novo NAD synthes

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Muroya, Yoshikazu, Osamu Ito, Rong Rong, et al. "Abstract 135: Alubuminuria Causes Disorder of Cytochrome P450 Metabolism of Arachidonic Acid in the Kidney of Nephrotic Rats." Hypertension 60, suppl_1 (2012). http://dx.doi.org/10.1161/hyp.60.suppl_1.a135.

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Alubuminuria is an aggravating factor for chronic kidney disease. Fatty acids bound to albumin are overloaded to the proximal tubules in alubuminuria and contribute to tubulointerstitial damage. It is known not only the β-oxidation ability but the ability of cytochrome P450 (CYP) metabolism of arachidonic acid (AA) is high in the kidney. Epoxyeicosatrienoic acids synthesized primarily by CYP2C and 20-hydroxyeicosatetraenoic acid synthesized by CYP4A affect tubular function and renal circulation. However, it isn’t clear CYP metabolism of AA would change in alubuminuria. The study tested changes

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Luo, Zhenghui, Weifei Wei, Ruijie Ma, et al. "Approaching 20% Efficiency in Ortho‐Xylene Processed Organic Solar Cells by a Benzo[a]phenazine‐Core‐Based 3D Network Acceptor with Large Electronic Coupling and Long Exciton Diffusion Length." Advanced Materials, August 13, 2024. http://dx.doi.org/10.1002/adma.202407517.

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AbstractHigh‐performance organic solar cells often rely on halogen‐containing solvents, which restrict the photovoltaic industry. Therefore, it is imperative to develop efficient organic photovoltaic materials compatible with halogen‐free solvents. Herein, a series of benzo[a]phenazine (BP)‐core‐based small‐molecule acceptors (SMAs) achieved through an isomerization chlorination strategy is presented, comprising unchlorinated NA1, 10‐chlorine substituted NA2, 8‐chlorine substituted NA3, and 7‐chlorine substituted NA4. Theoretical simulations highlight NA3's superior orbit overlap length and ti

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Paolini, Guido, Guido Firmani, Francesca Briganti, Michail Sorotos, and Fabio Santanelli di Pompeo. "Guiding Nipple-Areola Complex Reconstruction: Literature Review and Proposal of a New Decision-Making Algorithm." Aesthetic Plastic Surgery, November 20, 2020. http://dx.doi.org/10.1007/s00266-020-02047-9.

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Abstract Background Nipple-areola complex reconstruction (NAR) most commonly represents the finishing touch to breast reconstruction (BR). Nipple presence is particularly relevant to the patient’s psyche, beyond any shadow of doubt. Many reconstructive options have been described in time. Surgery is easy, but final result is often disappointing on the long run. Methods The goal of this manuscript is to analyze and classify knowledge concerning NAR techniques and the factors that influence success, and then to elaborate a practical evidence-based algorithm. Out of the 3136 available articles as

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Yaku, Keisuke, Sailesh Palikhe, Hironori Izumi, et al. "BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities." Nature Communications 12, no. 1 (2021). http://dx.doi.org/10.1038/s41467-021-27080-3.

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AbstractNicotinamide riboside (NR) is one of the orally bioavailable NAD+ precursors and has been demonstrated to exhibit beneficial effects against aging and aging-associated diseases. However, the metabolic pathway of NR in vivo is not yet fully understood. Here, we demonstrate that orally administered NR increases NAD+ level via two different pathways. In the early phase, NR was directly absorbed and contributed to NAD+ generation through the NR salvage pathway, while in the late phase, NR was hydrolyzed to nicotinamide (NAM) by bone marrow stromal cell antigen 1 (BST1), and was further met

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Testera‐Montes, Almudena, Adriana Ariza, Rosa Alba Sola‐Martinez, et al. "Investigation of the diagnostic accuracy of basophil activation test for allergic phenotypes of rhinitis." Allergy, November 5, 2024. http://dx.doi.org/10.1111/all.16390.

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AbstractIntroductionBasophil activation test (BAT) might be an alternative to nasal allergen challenge (NAC) to identify the allergic etiology in rhinitis patients. Here, we investigate the diagnostic performance of BAT for allergic phenotypes of rhinitis.MethodsRhinitis patients and healthy controls were subjected to NAC with Dermatophagoides pteronyssinus (DP), Alternaria alternata (AA), grass (GP) and olive (OP) pollens. Rhinitis subjects also underwent skin prick test (SPT) with relevant allergens. Patients were classified into allergic rhinitis (AR, positive NAC and SPT), local allergic r

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Mohammadi Pour, Pardis, Zeinab Nouri, Dariush Ghasemi, Soraya Sajadimajd та Mohammad Hosein Farzaei. "Cytotoxic Impact of Naringenin-Loaded Solid Lipid Nanoparticles on RIN5F Pancreatic β Cells via Autophagy Blockage". Recent Advances in Drug Delivery and Formulation 18 (7 серпня 2024). http://dx.doi.org/10.2174/0126673878297658240804192222.

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Background: Autophagy plays a crucial role in modulating the proliferation of cancer diseases. However, the application of Naringenin (Nar), a compound with potential benefits against these diseases, has been limited due to its poor solubility and bioavailability. Objective: This study aimed to develop solid lipid nanoparticles (Nar-SLNs) loaded with Nar to enhance their therapeutic impact. Methods: In vitro experiments using Rin-5F cells exposed to Nar and Nar-SLNs were carried out to investigate the protective effects of Nar and its nanoformulation against the pancreatic cancer cell line of

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