Academic literature on the topic 'Nardostachys'

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Journal articles on the topic "Nardostachys"

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Bian, Li-hua, Zi-wei Yao, Cheng-bowen Zhao, Qiu-yu Li, Jin-li Shi, and Jian-you Guo. "Nardosinone Alleviates Parkinson’s Disease Symptoms in Mice by Regulating Dopamine D2 Receptor." Evidence-Based Complementary and Alternative Medicine 2021 (August 13, 2021): 1–14. http://dx.doi.org/10.1155/2021/6686965.

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Nardostachyos Radix et Rhizoma (nardostachys) is the root and rhizome of Nardostachys jatamansi DC. Recent studies have shown that nardostachys may exert an anti-PD effect. In this study, the UHPLC-LTQ-Orbitrap-MS method was used to analyze the brain components of nardostachys in rats. Based on the results of UHPLC-LTQ-Orbitrap-MS analysis, nardosinone was identified to be the most effective anti-PD compound in nardostachys. To further verify this inference, a mouse PD model was established and the effect of nardosinone on PD mice was determined using classic behavioral tests. The results showed that nardosinone was indeed effective for relieving PD symptoms in mice. Moreover, network pharmacology analysis was used to elucidate the mechanism underlying the anti-PD effect of nardosinone. Dopamine receptor D2 (DRD2) was identified as the key target of nardosinone-PD interaction network, which was further verified by molecular docking and Western blotting. The results demonstrated that nardosinone and DRD2 could interact with each other. Furthermore, the expression level of DRD2 was decreased in the brain tissue of PD mice, and nardosinone could restore its expression to a certain extent. In conclusion, our findings suggest that nardosinone may reduce the motor and cognitive symptoms in the animal PD model by regulating DRD2 expression.
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Li, Junjun, Jie Wu, Kezhong Peng, Gang Fan, Haiqing Yu, Wenguo Wang, and Yang He. "Simulating the effects of climate change across the geographical distribution of two medicinal plants in the genus Nardostachys." PeerJ 7 (April 16, 2019): e6730. http://dx.doi.org/10.7717/peerj.6730.

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Background The medicinal plants of Radix et Rhizoma Nardostachyos include Nardostachys jatamansi and N. chinensis. Traditionally, the two plants have been used to treat many diseases. Because of their special aroma, they are also commonly used in the food and cosmetics industry. Recently, N. jatamansi and N. chinensis have been overexploited due to their economic importance, resulting in a sharp decline in their wild resources. Predicting potential distributions of the genus Nardostachys under different climate scenarios and understanding its preferred habitat are of great significance for their conservation, artificial cultivation, and assessment of their value. Methods The Maxent model was used to predict the potential geographical distributions of the genus Nardostachys under current and future climatic conditions based on two representative concentration pathways (RCP2.6 and RCP8.5) for the 2050s and 2070s. These data were used to study the effects of climate variables. Results The results show that the potential distribution of the two species will increase, thus more suitable habitats will be present in China. The suitable habitat for N. chinensis presents a relatively stable growth compared to N. jatamansi. In addition, precipitation plays a crucial role in modeling the effects of climate change on the genus Nardostachys. This study provides theoretical guidance for the cultivation of N. chinensis.
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ITOKAWA, Hideji, Koichi MASUYAMA, Hiroshi MORITA, and Koichi TAKEYA. "Cytotoxic Sesquiterpenes from Nardostachys chinensis." CHEMICAL & PHARMACEUTICAL BULLETIN 41, no. 6 (1993): 1183–84. http://dx.doi.org/10.1248/cpb.41.1183.

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Chatterjee, Asima, Utpal Dutta, Debasish Bandyopadhyay, Anupam Nayak, Bidyut Basak, Avijit Banerji, and Julie Banerji. "An Overview of the Genus Nardostachys." Natural Product Communications 2, no. 11 (November 2007): 1934578X0700201. http://dx.doi.org/10.1177/1934578x0700201124.

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Nardostachys jatamansi, a medicinally important herb of Nepalese origin, has been used for centuries in the Ayurvedic and Unani systems of medicine. In combination with Marsilea minuta it is being used as an antistress and anticonvulsant drug and also finds use in the treatment of epilepsy. Recently, it has been reported that N. jatamansi, which plays an important role in protecting from cerebral ischemia and liver damage, is also used for the treatment of osteoporosis and hypercalcemia. The other member of the genus Nardostachys, N. chinensis, possesses antifungal and antimalarial properties. It is also used in the treatment of skin dysfunction. A short summary of the chemical constituents of the two species along with their physical and biological properties is reported.
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Liu, Ming-Li, Ying-Hui Duan, Jin-Bo Zhang, Yang Yu, Yi Dai, and Xin-Sheng Yao. "Novel sesquiterpenes from Nardostachys chinensis Batal." Tetrahedron 69, no. 32 (August 2013): 6574–78. http://dx.doi.org/10.1016/j.tet.2013.05.134.

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Wu, Pei-Qian, Yi-Fan Yu, Ye Zhao, Chun-Xue Yu, De-Juan Zhi, Feng-Ming Qi, Dong-Qing Fei, and Zhan-Xin Zhang. "Four novel sesquiterpenoids with their anti-Alzheimer's disease activity from Nardostachys chinensis." Organic & Biomolecular Chemistry 16, no. 46 (2018): 9038–45. http://dx.doi.org/10.1039/c8ob02319k.

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Nardochinins A–D (1–4), four novel sesquiterpenoids, were isolated from Nardostachys chinensis. Nardochinin B (2) can significantly inhibit the Alzheimer's disease (AD) like symptom of worm paralysis.
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Satyal, Prabodh, Bhuwan K. Chhetri, Noura S. Dosoky, Ambika Poudel, and William N. Setzer. "Chemical Composition of Nardostachys grandiflora Rhizome Oil from Nepal – A Contribution to the Chemotaxonomy and Bioactivity of Nardostachys." Natural Product Communications 10, no. 6 (June 2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000668.

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The essential oil from the dried rhizome of Nardostachys grandiflora, collected from Jaljale, Nepal, was obtained in 1.4% yield, and a total of 72 compounds were identified constituting 93.8% of the essential oil. The rhizome essential oil of N. grandiflora was mostly composed of calarene (9.4%), valerena-4,7(11)-diene (7.1%), nardol A (6.0%), 1(10)-aristolen-9-ol (11.6%), jatamansone (7.9%), valeranal (5.6%), and cis-valerinic acid (5.7%). The chemical composition of N. grandiflora rhizome oil from Nepal is qualitatively very different than those from Indian, Chinese, and Pakistani Nardostachys essential oils. In this study we have evaluated the chemical composition and biological activities of N. grandiflora from Nepal. Additionally, 1(10)-aristolen-9-ol was isolated and the structure determined by NMR, and represents the first report of this compound from N. grandiflora. N. grandiflora rhizome oil showed in-vitro antimicrobial activity against Bacillus cereus, Escherichia coli, and Candida albicans (MIC = 156 μg/mL), as well as in-vitro cytotoxic activity on MCF-7 cells.
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Zhao, Ye, Bing Li, Yi-Fan Yu, Pei-Qian Wu, Chun-Xue Yu, Pan-Jie Su, De-Juan Zhi, Feng-Ming Qi, Dong-Qing Fei, and Zhan-Xin Zhang. "Narjatamanins A and B, a pair of novel epimers possessing a 2,3-seco-iridoid skeleton with an unusual 1,10-oxygen bridge from Nardostachys jatamansi and evaluation of their effects on worm paralysis in AD C. elegans." RSC Advances 9, no. 42 (2019): 24333–37. http://dx.doi.org/10.1039/c9ra04485j.

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Yoon, Chi-Su, Dong-Cheol Kim, Jin-Soo Park, Kwan-Woo Kim, Youn-Chul Kim, and Hyuncheol Oh. "Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites from Nardostachys jatamansi." Molecules 23, no. 9 (September 17, 2018): 2367. http://dx.doi.org/10.3390/molecules23092367.

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Nardostachys jatamansi contains various types of sesquiterpenoids that may play an important role in the potency of plant’s anti-inflammatory effects, depending on their structure. In this study, five new sesquiterpenoids, namely kanshone L (1), kanshone M (2), 7-methoxydesoxo-narchinol (3), kanshone N (4), and nardosdaucanol (5), were isolated along with four known terpenoids (kanshone D (6), nardosinanone G (7), narchinol A (8), and nardoaristolone B (9)) from the rhizomes and roots of Nardostachys jatamansi. Their structures were determined by analyzing 1D and 2D NMR and MS data. Among the nine sesquiterpenoids, compounds 3, 4, and 8 were shown to possess dose-dependent inhibitory effects against lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production in BV2 microglial cells. Furthermore, compounds 3, 4, and 8 exhibited anti-neuroinflammatory effects by inhibiting the production of pro-inflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-12 and tumor necrosis factor-α (TNF-α), in LPS-stimulated BV2 microglial cells. Moreover, these compounds were shown to inhibit the activation of the NF-κB signaling pathway in LPS-stimulated BV2 microglial cells by suppressing the phosphorylation of IκB-α and blocking NF-κB translocation. In conclusion, five new and four known sesquiterpenoids were isolated from Nardostachys jatamansi, and compounds 3, 4, and 8 exhibited anti-neuroinflammatory effects in LPS-stimulated BV2 microglial cells through inhibiting of NF-κB signaling pathway.
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Purohit, Vijay K., R. S. Chauhan, Harish C. Andola, P. Prasad, M. C. Nautiyal, and A. R. Nautiyal. "Nardostachys jatamansiDC: Conservation, multiplication and policy issues." Medicinal Plants - International Journal of Phytomedicines and Related Industries 4, no. 3 (2012): 162. http://dx.doi.org/10.5958/j.0975-4261.4.3.019.

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Dissertations / Theses on the topic "Nardostachys"

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Ghimire, Suresh Kumar. "Pratiques de cueillette et écologie de la conservation de plantes médicinales de l’Himalaya Népalais : approches ethnoécologique et écologique." Montpellier 2, 2005. http://www.theses.fr/2005MON20227.

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Un grand nombre de plantes médicinales (PMs) sont menacées en Himalaya à cause de la surexploitation pour le commerce. Il est urgent de développer des connaissances concernant des pratiques durables d’exploitation. Nous avons documenté les connaissances ethnobotaniques et ethnoécologiques ainsi que les pratiques de gestion, associées aux PMs au Dolpo (nord-ouest du Népal) dans des sociétés de culture tibétaine et mixte tibéto-népalaise. Les savoirs locaux et les pratiques de cueillette ont été intégrés dans des dispositifs de recherche écologique pour évaluer l'impact de l'utilisation des ressources sur les PMs aux niveaux des populations et du paysage, afin de renseigner des approches de gestion soutenable. Nous avons trouvé un corpus riche de connaissances locales concernant l'utilisation, l'ethnoécologie et la gestion des PMs. Les savoirs locaux et les modes de gestion sont sensiblement différents au sein des groupes sociaux et entre ces groupes, et cette variation a été reliée à des facteurs socioculturels et économiques. La diversité et l'abondance d'espèces de PM au niveau du paysage ont été reliées à la diversité des pratiques d'utilisation et à l'hétérogénéité des conditions écologiques. Au niveau des populations, l'effet de la cueillette s'est avéré dépendre non seulement de l’intensité et des approches de cueillette mais également des conditions d'habitat et des modèles de croissance des espèces considérées. Fondé sur l’étude de cas de deux espèces vivaces (Nardostachys grandiflora [Valerianaceae] et Neopicrorhiza scrophulariiflora [Scrophulariaceae]), nous concluons qu’il est plus facile de développer des pratiques durables pour certaines espèces que pour d'autres, à cause des différences dans leurs stratégies de croissance et des variations environnementales qui affectent la rapidité de récupération des populations après des pertes d'individus. Notre étude apporte des connaissances nouvelles sur la façon dont les pratiques humaines structurent la dynamique des PMs aux niveaux des populations et du paysage et sur la façon dont l’étude des savoirs et pratiques locaux peut contribuer à formuler des pratiques plus soutenables
A large number of medicinal plants (MPs) are threatened in the Himalaya due to over-exploitation for trade. Knowledge of the sustainability of their use is urgently needed. We documented ethnobotanical and ethnoecological knowledge and management practices related to MPs harvesting in Dolpo (northwestern Nepal) in Tibetan and mixed Tibeto-Nepalese societies. Local knowledge and harvesting patterns were incorporated in to the design of ecological studies, the objectives of which were to assess the impact of resource use on MPs at population and landscape levels, and thereby to inform sustainable management practices. We found a rich body of local knowledge relating to the use, ethnoecology and management of MPs. Local knowledge and management practices varied substantially within and between social groups, and were related to socio-cultural and economic factors. MP species diversity and abundance at the landscape-level were related to the diversity of human resource use practices and to heterogeneity in ecological conditions. At the population level, the effect of harvesting was found to depend not only on harvesting intensities and approaches but also on habitat conditions and growth patterns of the concerned species. Based on the cases of two perennial species, Nardostachys grandiflora (Valerianaceae) and Neopicrorhiza scrophulariiflora (Scrophulariaceae), we conclude that the goal of harvesting sustainability appears to be more easily attained for some species than for others, owing to differences in their growth strategies and in relation to environmental variation that affects the rapidity of recovery of populations from the loss of individuals. Our study brings new elements towards understanding how current human management shapes the structure and dynamics of MPs at population and landscape levels, and clarifies how studies of local knowledge and practices may be used to design more sustainable practices
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Book chapters on the topic "Nardostachys"

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Bährle-Rapp, Marina. "Nardostachys jatamansi." In Springer Lexikon Kosmetik und Körperpflege, 373. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_6867.

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Khare, C. P. "Nardostachys jatamansi DC." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_1057.

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Kunwar, Ripu M., Rainer W. Bussmann, and Narel Y. Paniagua-Zambrana. "Nardostachys grandiflora DC. Caprifoliaceae." In Ethnobotany of the Himalayas, 1–3. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45597-2_159-1.

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Kunwar, Ripu M., Rainer W. Bussmann, and Narel Y. Paniagua-Zambrana. "Nardostachys grandiflora DC. Caprifoliaceae." In Ethnobotany of the Himalayas, 1345–47. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57408-6_159.

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Saroya, Amritpal Singh, and Jaswinder Singh. "Neuropharmacology of Nardostachys jatamansi DC." In Pharmacotherapeutic Potential of Natural Products in Neurological Disorders, 167–74. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0289-3_17.

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Akbar, Shahid. "Nardostachys jatamansi (D. Don) DC (Caprifoliaceae)." In Handbook of 200 Medicinal Plants, 1269–77. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-16807-0_133.

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"NARDOSTACHYS (Valerianaceae)." In Directory Of Plants Containing Secondary Metabolites, 817–19. CRC Press, 1991. http://dx.doi.org/10.1201/b12561-323.

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"Ethnopharmacology of Nardostachys jatamansi DC." In Herbalism, Phytochemistry and Ethnopharmacology, 362–67. Science Publishers, 2011. http://dx.doi.org/10.1201/b10878-22.

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"Nardostachys jatamansi DC. — The Indian Nard." In Biotechnology of Medicinal Plants, 217–38. CRC Press, 2004. http://dx.doi.org/10.1201/9781482280227-12.

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Conference papers on the topic "Nardostachys"

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Purohit, Vijay K., P. Prasad, M. C. Nautiyal, and A. R. Nautiyal. "Propagation of highly important life saving herbs Nardostachys grandiflora DC. via conventional and biotechnological approaches." In 3rd Annual International Conference on Advances in Biotechnology (BioTech 2013). Global Science and Technology Forum, 2013. http://dx.doi.org/10.5176/2251-2489_biotech13.12.

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