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Dissertations / Theses on the topic 'Nasal polyp'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Lau, Laurie Chi-Kwong. "Studies on the release characteristics and pharmacological regulation of mast cells dispersed from human nasal polyp tissue." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295754.

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2

Carvalho, Liliana Sofia Machado de. "Expression of cyclooxygenase enzymes and prostaglandin E2 receptors in inflammatory airway diseases." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6347.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Aspirin-intolerant asthma (AIA) is a syndrome where the interplay between cyclooxygenase (COX) and lipoxygenase (LOX) pathways is evident and is characterized by several abnormalities in the regulation and biosynthesis of eicosanoid mediators and eicosanoid receptors. Several observations indicate the presence of a complex change in the arachidonic acid (AA) metabolism in patients who suffer from AIA. However, previous studies showed some discrepant results when upper and lower airways were analyzed, and there

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3

Júnior, Emanuel Capistrano Costa. "Avaliação da associação entre biofilmes bacterianos, bactérias intracelulares e superantígenos estafilocócicos em pacientes com rinossinusite crônica." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17151/tde-10042018-141217/.

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Introdução: Embora a fisiopatogenia da rinossinusite crônica (RSC) ainda não esteja totalmente elucidada, em virtude da sua heterogeneidade e multifatorialidade, existe um crescente corpo de evidências apontando que as bactérias exerçam um papel significativo na gênese ou perpetuação da inflamação crônica. Uma das possíveis formas de atuação são os biofilmes bacterianos, comumente encontrados em pacientes com RSC e que estão relacionados com má evolução clínica. Ainda, existem evidências de que algumas espécies bacterianas, especialmente o Staphylococcus aureus (S. aureus), são capazes de inva

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4

Drake-Lee, Adrian. "Nasal polyps." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760576.

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5

Henriksson, Gert. "Clinical, immunological and olfactory aspects of sinusitis and nasal polyposis : with special reference to patients with cystic fibrosis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-151-2/.

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6

Dinarte, Vanessa Ramos Pires. "Associação genética do polimorfismo do receptor alfa 1 da interleucina 22 à rinossinusite crônica com e sem polipose nasossinusal." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17151/tde-26042018-171434/.

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Introdução: A rinossinusite crônica (RSC), doença multifatorial, na qual podem estar envolvidos fatores genéticos e ambientais, ainda tem muitos aspectos obscuros na sua patogênese. A genética tem se mostrado promissora na elucidação dessa complexa doença. Alguns estudos apontam que a expressão de interleucina (IL) 22 se apresenta reduzida em pacientes com RSC, podendo resultar também na redução da barreira epitelial e diminuição da produção de citocinas pró-inflamatórias Th1. Objetivos: Pesquisar a frequência dos polimorfismos no gene IL22RA1 (receptor subunidade alfa um da interleucina 22) e

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7

Canata, Diego Mena. "Perfil redox da classificação clínica de polipose nasal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/143816.

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Introdução: A polipose nasal (PN) é considerada uma condição inflamatória crônica da mucosa da cavidade nasal e seios paranasais de etiologia não muito clara. Há poucos dados sobre alterações epiteliais em PN e sua relação com a ação dos radicais livres. Muitas doenças estão ligadas a danos causados por espécies reativas de oxigênio (ROS) e de nitrogênio (RNSS) e ocorrem de um desequilíbrio entre eles e antioxidantes, o que for maior atividade de espécies reativas, o que chamamos de estresse oxidativo. Objetivo: O objetivo principal deste estudo é avaliar o estresse oxidativo em pólipos removi

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8

Bezerra, Thiago Freire Pinto. "O papel do biofilme na rinossinusite crônica com polipose nasossinusal." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-01082012-135039/.

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Introdução: A patogenia da rinossinusite crônica com polipose nasossinusal não está completamente estabelecida e existem algumas explicações para essa doença como os superantigenos, o desequilíbrio inflamatório e, mais recentemente, o biofilme. Objetivos: Avaliar a associação entre a presença do biofilme e a presença de rinossinusite crônica com polipose nasossinusal. Avaliar o quadro clínico e radiológico pré-operatória e pós-operatória segundo a presença do biofilme. Métodos: Este é uma estudo realizado em um hospital terciário universitário. A primeira parte foi um estudo caso-controle com

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9

Hedén, Blomqvist Ebba. "Evaluation of medical and/or surgical treatment of anosmia/hyposmia in association with inflammatory disease of the upper airway /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-930-7.

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10

Albarki, Mohammed Abdulhussein Handooz. "Evaluation of poly D, L lactic-co-glycolic acid (PLGA) nanoparticle uptake pathways across the nasal mucosa." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6905.

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The nasal mucosa provides a non-invasive route for drug administration to the systemic circulation and potentially directly to the CNS. Nanoparticles made from biodegradable polymers, including PLGA, are of great interest for use in drug delivery systems due to their relative safety and ease of surface modification. Owing to their small size, nanoparticles may provide enhanced targeting and transport through the nasal mucosa. An improved understanding of the mechanisms and pathways of nanoparticle transfer across the nasal mucosa is needed to design effective new nasal delivery systems. This s

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11

Лозовий, Р. О. "Хронічний поліпозний риносинусит. Сучасні аспекти лікування". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/48312.

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Актуальність. На даний час проблема поліпозного риносинуситу (ПРС) має важливе медико-соціальне значення. За даними різних авторів, у світі на ПРС страждає 4-5% населення. В Україні за останні роки захворюваність на риніти, риносинусити та ринофарингіти зросла і сягає 489,9 на 100 тис. населення. Широка поширеність ПРС у структурі захворювань ЛОР-органів, її зв’язок з бронхолегеневою патологією, тривалий перебіг ведуть до зниження працездатності, якості життя та інвалідизації хворих.

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12

Jabr, Suha Said Mohammad. "Contribution to the Study of the Role of Arachidonic Acid Metabolism in Airway Inflammatory Diseases (Nasal polyps, Asthma and Cystic Fibrosis)." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/125775.

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Eicosanoids are derived from the fatty acids that make up the cell membrane and nuclear membrane. They begin as a single poly unsaturated fatty acid, the arachidonic acid. (AA) is produced from membrane phospholipids and then it can be enzymatically metabolized through the cycloooxygenase pathway into different eicosanoids including prostaglandins. They have various roles in inflammation, and many diseases including asthma, and cystic fibrosis. Fibroblasts from nasal polyps of asthma patients have reduced expression of cyclooxygenase-2 and production of prostaglandin (PG) E2. It is hypothesize

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13

Albarki, Mohammed Abdulhussein Handooz. "In vitro assessment of the transport of Poly D, L Lactic-Co-Glycolic Acid (PLGA) nanoparticles across the nasal mucosa." Thesis, University of Iowa, 2016. https://ir.uiowa.edu/etd/2034.

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The nasal mucosa provides a rapid, noninvasive route for drug administration to the systemic circulation and even potentially to the CNS. Nanoparticles made from the biodegradable polymer, PLGA, are of great interest for use in drug delivery systems due to PLGA’s relative safety and ease of surface modification. Nanoparticles may provide improved targeting and transport through the nasal mucosa. However, the optimal nanoparticle sizes and surface properties for intranasal delivery are unknown. In this study, we prepared PLGA nanoparticles within a size range of 50-70 nm containing the lipophil

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14

Steffen, Luciane Mazzini. "Associa??o entre as altera??es da via a?rea superior e marcadores de progress?o da doen?a em pacientes com fibrose c?stica." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2017. http://tede2.pucrs.br/tede2/handle/tede/8211.

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Submitted by PPG Pediatria e Sa?de da Crian?a (pediatria-pg@pucrs.br) on 2018-07-12T11:24:06Z No. of bitstreams: 1 Disserta??oLu SteffenVers?oFinal.pdf: 1086203 bytes, checksum: 9b8f206613da0e87460cd6110bcec5ac (MD5)<br>Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-07-17T11:24:05Z (GMT) No. of bitstreams: 1 Disserta??oLu SteffenVers?oFinal.pdf: 1086203 bytes, checksum: 9b8f206613da0e87460cd6110bcec5ac (MD5)<br>Made available in DSpace on 2018-07-17T11:32:31Z (GMT). No. of bitstreams: 1 Disserta??oLu SteffenVers?oFinal.pdf: 1086203 bytes, checksum: 9b8f206613

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15

Brummitt, Marissa. "Development of CubeSat Vibration Testing Capabilities for the Naval Postgraduate School and Cal Poly San Luis Obispo." DigitalCommons@CalPoly, 2010. https://digitalcommons.calpoly.edu/theses/470.

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The Naval Postgraduate School is currently developing their first CubeSat, the Solar Cell Array Tester CubeSat, or NPS-SCAT. Launching a CubeSat, such as NPS-SCAT, requires environmental testing to ensure not only the success of the mission, but also the safety of other CubeSats housed in the same deployer. This thesis will address the development of CubeSat vibration testing methodology at NPS, including subsystem testing, engineering unit qualification, and flight unit testing. In addition, the new Cal Poly CubeSat Test POD Mk III will be introduced and evaluated based upon comparison with t

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16

Soter, Ana Carolina Pinto Bezerra. "Avaliação prospectiva aberta do uso prolongado de baixas doses de doxyciclina na rinossinusite crônica com polipose nasal de difícil tratamento." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-18122017-102426/.

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Introdução: A rinossinusite crônica com polipose nasal constitui um subgrupo particular da rinossinusite crônica, caracterizado por uma inflamação da mucosa que leva a um espessamento da mesma e à formação de pólipos, podendo ser especialmente difícil de tratar. A Doxiciclina é um antibiótico bacteriostático, de largo espectro, que também tem uma ação antiinflamatória, e tem se mostrado útil no controle dos sintomas das recidivas desta doença, promovendo inclusive uma diminuição do pólipo. Objetivo: avaliar se o uso de baixas doses de Doxiciclina, por períodos prolongados, pode melhorar o cont

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17

Nakanishi, Marcio. "Polipose nasal: caracterização da infiltração dos eosinófilos, mastócitos, miofibroblastos e células TGF-beta positivas em indivíduos com e sem asma." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-09102014-141937/.

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Para identificar, quantificar e correlacionar os eosinófilos, mastócitos, miofibroblastos e células TGF-beta positivas nos pólipos nasais de pacientes com e sem asma foi realizado a imunoistoquímica. A quantidade de eosinófilos, miofibroblastos e células TGF-beta positivas esteve aumentada no pólipo nasal de indivíduos asmáticos. O número de mastócitos não mostrou diferença entre os grupos. O miofibroblasto foi o denominador comum na correlação entre eosinófilos, mastócitos, células TGF-beta positivas e presença de asma<br>Introduction: Nasal polyposis is a chronic inflammatory disease of the

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18

Gutsche, Manuela. "Polyposis nasi: Quantitative Analyse der eosinophilen Granulozyten mit der Laser Scanning Zytometrie." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-64179.

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In der vorliegenden Arbeit wurde Gewebe aus den Nasennebenhöhlen von Patienten mit Nasenpolypen untersucht. Außerdem wurden Zusammenhänge zwischen den Zellpopulationen und den Angaben zu allergischen Erkrankungen und wiederholtem Auftreten der Polypen analysiert. Es fand sich eine interindividuell unterschiedlich starke Infiltration mit eosinophilen Granulozyten. Es konnten keine Unterschiede in der prozentualen Verteilung von eosinophilen Granulozyten im Polypengewebe bei allergischen/ nichtallergischen Patienten oder Patienten mit/ ohne Rezidiv nachgewiesen werden. Die Untersuchungen erfolgt

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19

Bruno, Liam T. "Three Axis Attitude Control System Design and Analysis Tool Development for the Cal Poly CubeSat Laboratory." DigitalCommons@CalPoly, 2020. https://digitalcommons.calpoly.edu/theses/2288.

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The Cal Poly CubeSat Laboratory (CPCL) is currently facing unprecedented engineering challenges—both technically and programmatically—due to the increasing cost and complexity of CubeSat flight missions. In responding to recent RFPs, the CPCL has been forced to find commercially available solutions to entire mission critical spacecraft subsystems such as propulsion and attitude determination & control, because currently no in-house options exist for consideration. The commercially available solutions for these subsystems are often extremely expensive and sometimes provide excessively good perf

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20

Cheng, YK, and 鄭元凱. "Nasal Polyp and Nasal Allergy with Special Reference to the Oxidative Stress." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/56236091527632525150.

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21

Lee, Ya-Wen, and 李雅雯. "Quantitative Analysis of Nasal Polyp and Maxillary Bone Using CT Images." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/98362445219768813527.

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碩士<br>國立臺灣大學<br>資訊工程學研究所<br>104<br>Chronic rhinosinusitis (CRS) is a common health care problem. Nasal polyps are the main factor to make the sinuses blocked causing the CRS and they grow up in the sinuses and even result in the expansion of anterior maxilla. Therefore, an automatic segmentation followed by quantitative measurement is proposed to obtain the volume of maxillary bone. First, the maxillary sinuses were detected and the maxillary bones were identified. The next step was calculating the volume of maxillary bones from a series of computed tomography images. As a result, the volume r

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22

Ho, Yin-Tzu, and 何尹慈. "Investigating the correlation between nasal polyp ZO-1 expression and eosinophil infiltration." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/11110053900450489274.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>104<br>Background: Previous studies have found that nasal tissues in most patients with chronic sinusitis exhibit eosinophil infiltration, and generally these patients show fungal infections and nasal polyps. Therefore, it is suggested that nasal polyps are associated with eosinophil infiltration. Although some studies have suggested that nasal polyps are linked to dysregulation of cell adhesion molecules (CAMs), the role of infiltrate eosinophils in expression of CAMs in nasal polys remains sketchy. Aims: This study was aimed to investigate the correlation betwee

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LI, CHIN-HSIN, and 李金杏. "The Mechanisms of Apoptosis and Cell Cycle Regulation in Nasal Polyp Tissues by Intranasal." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/06776876194457677021.

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碩士<br>中國醫藥學院<br>醫學研究所<br>91<br>Nasal Polyps are benign outgrowths of the mucosa in the nasal and paranasal cavities , consisting of edematous tissue infiltraded by inflammatory cells . Polyps development has been linked to chronic inflammation . In clinical , corticosteroid be used to decrease post surgery Nasal Polyps recurrent rate . Today , we will document the corticosteroids inhibited Polyps recurrent by regulated apoptosis and cell cycle in the tissue of Nasal Polyps . Polyp specimens were obtained from patients with nasal polyps , they had received corticosteroid(budesonide) treatment a

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Chien, Chen-Yu, and 簡禎佑. "The relationship between tagging single nucleotide polymorphisms in matrix metalloproteinase -2 (MMP-2) and nasal polyp." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/11538270153635684314.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>95<br>Objectives/Hypothesis: Matrix metalloproteinase (MMP) had an important role in the pathogenesis of nasal polyp. We hypothesized that genetic variants of the matrix metalloproteinase-2 (MMP-2) gene are associated with the development of nasal polyp. Methods: We conducted a case-control study in a total of 136 cases of nasal polyp and 136 controls. Seventeen single nucleotide polymorphisms (SNPs) were selected, including tagging SNPs and promoter functional polymorphism. The genotypes were determined by the TaqMan technology. Hardy-Weinberg equilibrium (HWE) was

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Cheng, Yuan-Kai, and 鄭元凱. "Studies on Oxidative Stress in Nasal Polyps." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/96280898060858321768.

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博士<br>東海大學<br>生命科學系<br>94<br>Nasal polyposis (NP) is a common chronic inflammatory disease of the upper respiratory tract. The etiology is unknown but has been shown to be multifactorial. NP is frequently associated with asthma; the interaction between these two comorbidities remains interesting. Free radical (FR)-mediated damage has been implicated in the pathogenesis of several diseases processes as a result of the oxidant-antioxidant imbalance, a condition called oxidative stress (OS). OS has been implicated in the pathophysiology of both NP and asthma. To investigate the significance

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Chen, Chung-Hsiung, and 陳忠雄. "Over expression of phospholipase A2 in nasal polyps." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/80008208657703469877.

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27

Teles, Rafaela da Cruz Vieira Veloso. "Study of the etiopathogenesis of Chronic Rhinosinusitis with Nasal Polyps." Doctoral thesis, 2020. http://hdl.handle.net/10400.6/10315.

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Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease, with high morbidity and chronicity, but its exact etiology is still unclear and remains a difficult to treat condition. Considering the emerging consensus that chronic rhinosinusitis (CRS) results from a dysfunctional host-environment interaction, this study pretends to clarify exogenous and endogenous factors, which can contribute to the occurrence and perpetuation of sinonasal mucosa inflammation observed in CRSwNP. The aims of this study are: 1) To evaluate endoscopic sinus surgery (ESS) efficacy in CRSwN

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Paiva, Bruno Daniel Pereira. "Nasal fossa schwannoma coexisting with vestibular schwannoma: a case report." Master's thesis, 2020. http://hdl.handle.net/10316/97658.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: O Schwannoma é um dos tumores mais comuns dos que crescem na bainha dos nervos periféricos. São sobretudo solitários e esporádicos, e quando múltiplos associam-se normalmente a etiologias genéticas. A localização mais comum é a porção vestibular do VIII par craniano, raramente envolvendo a fossa nasal. Caso Clínico: Apresenta-se o caso de um doente com um Schwannoma da fossa nasal esquerda em simultâneo com um provável Schwannoma vestibular esquerdo. Inicialmente, o doente dirigiu-se ao serviço

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Hsu, Ying-Che, та 許英哲. "The Expression of Hypoxia-inducible factor 1α in nasal polyps and its clinical correlation". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/74856152879196573031.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>94<br>Nasal polyps are originated from maxillary sinus, ethmoid sinus and the area near middle meatus, and its etiology and mechanism are still not well-known. The infection, inflammation and pressure, may be the pathogenesis.. Nasal polyps are recalcitrant disease in clinical rhinology. They make inconvenience and disturbance to patient’s daily life and the high recurrence rate also make a burden to medical insurance. Hypoxia-inducible factor-1 (HIF-1) is a DNA binding protein, which consist of a heterodimer HIF-1αand HIF-1βsubunits. HIF-1α protein is subject to ra

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Miljkovic, Dijana. "The role of immune cells in chronic rhinosinusitis." Thesis, 2017. http://hdl.handle.net/2440/109806.

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Chronic rhinosinusitis (CRS) is a heterogenous disease characterised by the symptomatic inflammation of the nose and paranasal sinuses for more than 12 weeks. These symptoms include nasal obstruction, nasal discharge, facial pain and pressure, resulting in a considerable impairment of a patients’ quality of life. CRS is subcategorised into two types based on the absence (CRSsNP) and presence of nasal polyps (CRSwNP) visualised within the middle meatus. Interestingly, although CRSsNP patients may lack easily identifiable polyps, the mucosa of these patients may show variable degrees of polypoid

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Couto, João José Pereira de Sá. "Asma exacerbada por AINEs: Fisiopatologia e o papel da terapêutica monoclonal." Master's thesis, 2020. http://hdl.handle.net/10316/97722.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>A asma é uma patologia clínica definida habitualmente como um distúrbio inflamatório das vias aéreas, quase sempre associada a hiperreatividade brônquica, caracterizando-se por episódios recorrentes de pieira, dispneia, opressão torácica e tosse, sintomas estes que poderão ser de predomínio matinal e/ou vespertino. Tal como inúmeras outras doenças conhecidas, esta pode ser dividida tendo em conta os seus diferentes fenótipos, entre os quais a Asma Exacerbada por Anti-Inflamatórios Não Esteroides. Esta entid

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Gutsche, Manuela. "Polyposis nasi: Quantitative Analyse der eosinophilen Granulozyten mit der Laser Scanning Zytometrie." Doctoral thesis, 2009. https://ul.qucosa.de/id/qucosa%3A11109.

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In der vorliegenden Arbeit wurde Gewebe aus den Nasennebenhöhlen von Patienten mit Nasenpolypen untersucht. Außerdem wurden Zusammenhänge zwischen den Zellpopulationen und den Angaben zu allergischen Erkrankungen und wiederholtem Auftreten der Polypen analysiert. Es fand sich eine interindividuell unterschiedlich starke Infiltration mit eosinophilen Granulozyten. Es konnten keine Unterschiede in der prozentualen Verteilung von eosinophilen Granulozyten im Polypengewebe bei allergischen/ nichtallergischen Patienten oder Patienten mit/ ohne Rezidiv nachgewiesen werden. Die Untersuchungen erfolgt

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Γιάννου, Αναστάσιος. "Επίδραση του TGF-β1και του MIF στην παραγωγή IL-6 από ινοβλάστες ρινικού πολύποδα και διερεύνηση της πιθανής συνέργειάς τους στην έκφρασή της". Thesis, 2013. http://hdl.handle.net/10889/8284.

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Ο ρινικός πολύποδας (ΡΠ) είναι μια χρόνια φλεγμονώδης νόσος του ρινικού βλεννογόνου, η οποία χαρακτηρίζεται από διήθηση φλεγμονωδών κυττάρων, όπως ηωσινόφιλα, λεμφοκύτταρα και πλασμοκύτταρα, τροποποιήσεις στη διαφοροποίηση του επιθηλίου και ανάπλαση ιστού, που περιλαμβάνει υπερπλασία της βασικής μεμβράνης, συσσώρευση εξωκυττάριου υλικού και οίδημα. Ο παράγοντας αναστολής της μετανάστευσης μακροφάγων (MIF) είναι μία μοναδική κυτταροκίνη με σημαντικό ρόλο στο σηπτικό σόκ και στις χρόνιες φλεγμονώδεις και αυτοάνοσες ασθένειες.Παράγεται από ενεργοποιημένα Τ-κύτταρα, μακροφάγα αλλά και από ποικιλ

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Σταθάς, Θεόδωρος. "Μελέτη του ρυθμιστικού ρόλου του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στην επίδραση των κορτικοειδών στην παραγωγή μεταλλοπρωτεασών και των ενδογενών αναστολέων τους, κυτταροκινών και κολλαγόνου στο ρινικό πολύποδα". Thesis, 2012. http://hdl.handle.net/10889/6152.

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Abstract:

Στην παρούσα διατριβή μελετήθηκε η έκφραση του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στον ιστό από ρινικό πολύποδα αλλά και στον φυσιολογικό ρινικό βλεννογόνο, καθώς και η ικανότητα αυτού να εξουδετερώνει την ανασταλτική δράση των γλυκοκορτικοειδών (ΓΚ) στην επαγόμενη από διάφορους αυξητικούς παράγοντες παραγωγή διαμεσολαβητών, όπως η IL-6 η MMP-1, η MMP-3 το κολλαγόνο τύπου-Ι και ο TIMP-1, που εμπλέκονται στη παθογένεια του ρινικού πολύποδα (ΡΠ). Ο MIF ανιχνεύθηκε στο μέσο καλλιέργειας όλων των ιστών και σε όλα τα εκχυλίσματα. Η έκφρασή του ήταν αυξημένη στον ρινικό πολύπ

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