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Tarrant, James C., David E. Holt, and Amy C. Durham. "Co-occurrence of Nasal Polyps and Neoplasms of the Canine Nasal Cavity." Veterinary Pathology 56, no. 6 (June 6, 2019): 885–88. http://dx.doi.org/10.1177/0300985819854438.
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Nasal polyps in dogs are space-occupying soft-tissue masses that have been encountered concurrently with intranasal neoplasia in surgical biopsy specimens. The proportion of nasal polyp co-occurrence with primary nasal tumors was examined, and follow-up biopsies on dogs initially diagnosed with nasal polyp were reviewed. Histologic sections from 321 cases of intranasal neoplasia and 50 cases of nasal polyp from 2004 to 2017 were reviewed. Of the 321 cases of intranasal neoplasia, 51 (16%) had concurrent nasal polyps, and most of these (47/51) had intranasal carcinoma. Twenty-five of the 50 dogs with a primary diagnosis of nasal polyp were rebiopsied, and the diagnoses in these subsequent biopsies were nasal polyp in 15, malignant neoplasm in 9, and intranasal nematode in 1. Nasal polyps occurred frequently in conjunction with nasal carcinoma. In dogs with a diagnosis of nasal polyp, repeat biopsy to reveal possible neoplasia is warranted.
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Špadijer-Mirković, Cveta, Aleksandar Perić, Biserka Vukomanović-Đurđević, and Ivan Stanojević. "CLINICAL CASE REPORT OF A LARGE ANTROCHOANAL POLYP." Acta Medica (Hradec Kralove, Czech Republic) 57, no. 2 (2014): 78–82. http://dx.doi.org/10.14712/18059694.2014.44.
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Antrochoanal polyps are benign lesions originating from the mucosa of the maxillary sinus. Nasal obstruction and rhinorrhea are their main symptoms. Their endoscopical and radiological appearance makes them relatively easy to diagnose. These polyps are usually presented unilaterally, although bilateral presentation is also possible. We described two cases of atypically giant antrochoanal polyps: in a 15-year-old child and in a 38-year-old man. In both cases, the diagnosis was done by nasal endoscopy and computed tomography (CT) of the paranasal sinuses and supported by histopathological analysis. In the first patient, the excised polyp had the histological characteristic of an angiomatous antrochoanal polyp. Because of their unusual dimension, the combined transoral and endonasal endoscopic approach was performed for complete polyp excision. We discussed the clinical, histopathological and immunohistochemical characteristics of choanal polyps in comparison to inflammatory nasal polyps, and the applicable surgical techniques for treatment of these polyps.
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Benninger, Michael S. "Nasal Endoscopy: Its Role in Office Diagnosis." American Journal of Rhinology 11, no. 2 (March 1997): 177–80. http://dx.doi.org/10.2500/105065897782537205.
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To clarify the role of nasal endoscopy in the diagnosis and treatment planning for patients with nasal or sinus complaints, 100 consecutive new patients were evaluated. Patients were excluded if their only complaint was obstruction and they had a septal deviation as the only clinical finding. Each patient underwent a thorough history and head and neck examination, including anterior rhinoscopy before and after decongestion, and the diagnosis and treatment plans were documented. Each then underwent nasal endoscopy, and the diagnosis and treatments were compared. The most common diagnoses after anterior rhinoscopy were allergic rhinitis (21), nonallergic rhinitis (12), chronic sinusitis with polyps (19) or without polyps (9), and nonsinus pain (13). Nasal endoscopy played a role in 11% of patients, although in no case did endoscopy change the diagnosis or treatment plan. Endoscopy allowed visualization past an enlarged turbinate or septal deviation in six patients, confirmed a suspected diagnosis in three by visualization of the middle meatus, and detected the site of a large choanal polyp in one. In one case, endoscopy identified a paradoxical turbinate on the side opposite the symptoms and radiological findings. Routine nasal endoscopy need not be part of the evaluation of all patients with nasal sinus disorders but is particularly valuable in confirming diagnoses, particularly in patients where anterior rhinoscopy is limited by anatomic vobstruction.
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Bennett, J. D. C., and C. R. Chowdhury. "Nasal Polyps -- A Preliminary Diagnosis." Journal of the Royal Army Medical Corps 139, no. 3 (October 1, 1993): 112–14. http://dx.doi.org/10.1136/jramc-139-03-08.
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Birinci, Mehmet, Suat Terzi, Metin Çeliker, and Engin Dursun. "Evaluation of peripheral blood cell levels in nasal polyposis, anthrochoanal polip and inverted papillom patients." International Journal of Otorhinolaryngology and Head and Neck Surgery 7, no. 8 (July 23, 2021): 1216. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20212894.
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<p class="abstract"><strong>Background:</strong> Nasal polyps, antrochoanal polyps and Inverted papilloma are nasal masses. The aim of this study the levels and rates of peripheral blood cells are examined in patients with nasal polyps, antrochoanal polyps, and inverted papilloma, and it is investigated whether peripheral blood elements can be used as a marker in the differential diagnosis of these three pathologies</p><p class="abstract"><strong>Methods: </strong>The files of 70 patients were retrospectively analyzed between January 2015 and December 2018. Patient were divided into three groups as inverted papilloma, nasal polyposis and antrochoanal polyp. Neutrophil, lymphocyte, eosinophil, monocyte and platelet counts, NLR, ELO, MLO, BLO and TLO values of each of these three groups were compared statistically separately.</p><p class="abstract"><strong>Results: </strong>A total of 70 patients, including 24 nasal polyps, 26 antrochoanal polyps, and 20 inverted papillomas, were included in the study. There was no statistical difference between the groups in terms of NLR, BLO, MLO, TLO (p=0.479). Only ELO value was higher in the nasal polyp group (p=0.035).</p><p><strong>Conclusions:</strong> As in many areas, easier and cheaper diagnostic methods and markers are needed in nasal cavity masses. In our study, we found no evidence that peripheral blood cells could be used to guide the diagnosis and treatment plan of the most common mass lesions of the nasal cavity. Broader and more comprehensive studies are needed for definitive results. </p>
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Schumacher, D. U., and C. J. Randall. "A survey to determine the extent of previous symptoms and surgery on patients presenting with nasal polyps." Journal of Laryngology & Otology 110, no. 8 (August 1996): 736–38. http://dx.doi.org/10.1017/s0022215100134838.
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AbstractThe aim of our study was to investigate the prevalence of surgery on the nose prior to first time diagnosis of nasal polyps. We interviewed 60 patients who presented to the ENT Department at the Royal South Hants Hospital Southampton and were diagnosed as suffering from nasal polyps for the first time. Patients who suffered from cystic fibrosis or known primary ciliary dyskinesia were excluded.The average length of time of nasal blockage as the main symptom prior to the diagnosis of nasal polyps was less than two years. Out of the 60 patients six (10 per cent) had had previous nasal surgery. Out of these six patients, only four patients had a previous procedure on the nose that could be considered to be related to the later diagnosis of nasal polyps. Only one patient had had radiological investigation of his sinuses in the past.We conclude that polypoid nasal disease is a de novo diagnosis with a relatively short history in the majority of patients and not preceded by a long history of ENT investigations nor surgery on the nose.
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Ahmad, Waseem, Muhammad Iqbal, and Gohar Amin. "NASAL POLYPS." Professional Medical Journal 25, no. 09 (September 10, 2018): 1417–20. http://dx.doi.org/10.29309/tpmj/2018.25.09.147.
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Background: Nasal polyposis is a provocative situation of indefinite etiology thatinvolve nasal as well as sinus mucous membrane. Quality of life of a person can damage by nasalimpediment due to these nasal polyps. Further, it can cause of persistent postnasal drainage,hyposmia, sinusitis, taste sense change even bony demolition. It shows that inflammationreason a reactive hyperplasia of intra-nasal mucosal membrane resulted in the polyp formation.Objectives: To discover the kind of fungus concerned in nasal polyps fungal. Study Design:Descriptive study. Setting: ENT department of Sir Ganga Ram Hospital Lahore. Period: 1stJanuary 2017 to 30th June 2017. Materials and Methods: In microbiology department, thesecollected samples were processed to check the involvement of fungal. Out of all, 118 caseswere included in this study which culture was positive. Increase for microscopic assessment,mycological culture to determine the involvement of fungal and fungus kind, these sampleswere processed for diagnosis by potassium hydroxide (KOH). By using seaboard dextroseagar at 25ºC and 37ºC the fungal culture was done. Periodically it was identified through culturecharacteristics & microscopy if growth was present. Results: In this study, 118 culture positivesamples were included. In 82 cases Aspergillus Spp. was observed among positive specimens;In 32 samples Aspergillus flavus was observed while in 10 samples Aspergillus fumigates wasfound and species was not cleared in 40 samples. The fungal element was isolated in 36samples but genus was not determined. Conclusion: In fungal nasal polyposis, AspergillusSpp. is very general pathogen and we observed in our study that Aspergillus flavus is verycommon agent.
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Yenigun, Alper, Yasin Kulaksiz, Tugce Esen Kiran, Erol Senturk, Fadlullah Aksoy, and Orhan Ozturan. "A Rare and Unexpected Reason for Unilateral Epistaxis: Nasal Septal Schwannoma." Case Reports in Otolaryngology 2020 (October 10, 2020): 1–5. http://dx.doi.org/10.1155/2020/4369620.
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Nasal septal schwannoma is a rare tumor. It causes complaints such as nasal congestion, nosebleeds, and headaches. There are many diseases such as nasal polyps, antrochoanal polyp, chronic rhinosinusitis, concha bullosa, inverted papilloma, and retention cyst with schwannoma diagnosis. The diagnosis is made histopathologically, and the treatment is surgery. In this case report, we presented a male patient with septal schwannoma who had nasal obstruction for a year and reviewed the last 20 years of literature on nasal schwannoma.
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Jagade, Mohan, Aseem Mishra, Saurabh Agarwal, VG Kasbekar, Vandana Thorawade, and Shreyas Joshi. "Sphenochoanal Polyp." An International Journal Clinical Rhinology 6, no. 1 (2013): 54–55. http://dx.doi.org/10.5005/jp-journals-10013-1150.
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ABSTRACT Nasal polyps are mostly referred to antrochoanal polyps and a sphenoid polyp is as such a rare entity. Computerized tomography and nasal endoscopy have contributed to an increase of accuracy in the diagnosis of these masses. Simple polypectomy that leaves some part of the polyp inside the sphenoid sinus carries a high risk of recurrence. Destructive external approaches to gain access to the sphenoid sinus are also not advisable in children for a benign disease. We present here a case of sphenochoanal polyp arising from right side sphenoid sinus. The sphenoid sinus disease is very rare and can be well-managed with endoscopic sinus surgery. How to cite this article Agarwal S, Mishra A, Jagade M, Kasbekar VG, Thorawade V, Joshi S. Sphenochoanal Polyp. Clin Rhinol An Int J 2013;6(1):54-55.
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Chaaban, Mohamad R., Erika M. Walsh, and Bradford A. Woodworth. "Epidemiology and Differential Diagnosis of Nasal Polyps." American Journal of Rhinology & Allergy 27, no. 6 (November 2013): 473–78. http://dx.doi.org/10.2500/ajra.2013.27.3981.
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Sarkar, Sucharita, Rama Saha, Mou Das, and Samares Sardar. "Sinonasal Polyps: A Diagnostic Challenge." Bengal Journal of Otolaryngology and Head Neck Surgery 27, no. 3 (December 29, 2019): 243–50. http://dx.doi.org/10.47210/bjohns.2019.v27i3.16.
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Introduction
Sinonasal polyps, presenting as mass lesion of nose and paranasal sinuses ranges pathologic entity including infective diseases to malignant lesions. 80% are non-neoplastic lesions and less than 1% are malignant. They all present with symptoms of nasal stuffiness or obstruction and mass lesion, producing significant diagnostic challenges as they possess extremely varied clinical behaviour, etiopathogenesis, treatment protocol as well as prognosis.
Case Series
During period of one year (March 2017 to February 2018), we had six patients presenting with nasal polyp having special features that need attention. After proper investigation each case was operated and gross examination followed by histopathology was done. They revealed six different diagnoses e.g., Olfactory neuroblastoma, Adenoid Cystic Carcinoma, Basal Cell Adenocarcinoma, Sinonasal Mucosal Melanoma, Primitive Neuroectodermal Tumour (PNET) and Aspergilloma.
Discussion
Clinicians’ attention is drawn to the fact that, similar presentation may have varied differential diagnoses, some of which may be very rare and histopathology is essential for coming to definitive diagnosis.
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Wardani, Retno Sulistyo, and Ika Dewi Mayangsari. "Woakes syndrome." Oto Rhino Laryngologica Indonesiana 44, no. 1 (October 8, 2014): 76. http://dx.doi.org/10.32637/orli.v44i1.86.
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Background: Extensive nasal polyp growth in the paranasal sinuses can lead to bone erosion of the sinus walls and cause facial disfigurement due to continuous pressure or chronic inflammation. This extremely rare phenomenon is called Woakes syndrome. This syndrome consist of several symptoms include the destruction of ethmoid sinus that cause broadening of the bridge of the nose, frontal sinus aplasia and bronchiectasis. Purpose: To give complete information about the diagnosis and management of Woakes Syndrome. Case: A 16-year-old boy with deformity of the left nose, nasal obstruction and frequent episodes of rhinorrhea since 4 months before admission. Nasoendoscopic evaluation showedhuge nasal polyps filling the left nasal cavity, pushing the septum and narrowing the right nasal cavity. Histopathology result was edematous polyp with necrosis and massive bleeding without signs of malignancy. Management: Patient was managed in two stages operations. First, nasal polyp removal by FESS technique in general anesthesia, and the second stage four months later, was septorhinoplasty for aesthetic bridge reconstruction. Conclusion: Nasal polyps could be related to Woakes syndrome, characterized by broadening of nasal bridge which needs functional and aesthetic surgery. Keyword: Woakes Syndrome, nasal polyps, Functional Endoscopic Sinus Surgery, Septorhinoplasty ABSTRAKLatar Belakang: Polip hidung besar yang meluas dalam sinus paranasal dapat menyebabkan erosi dinding sinus dan menyebabkan cacat wajah akibat tekanan terus-menerus atau peradangan kronis. Fenomena ini sangat langka dan disebut sebagai sindrom Woakes. Sindrom ini terdiri dari beberapa gejala termasuk kerusakan dinding sinus etmoid yang menyebabkan hidung melebar, aplasia sinus frontal dan bronkiektasis. Tujuan: Untuk memberikan informasi yang lengkap tentang diagnosis dan penatalaksanaan Woakes Syndrome. Kasus: Seorang anak laki-laki 16 tahun dengan deformitas hidung kiri, hidung tersumbat dan pilek berulang sejak 4 bulan. Evaluasi nasoendokopi menunjukkanpolip hidung masif mengisi rongga hidung kiri, mendorong septum dan menyempitkan rongga hidung kanan. Pemeriksan histo-patologi memperlihatkan polip edematosa dengan nekrosis dan perdarahan masif tanpa tanda-tanda keganasan. Penatalaksanaan: Pada pasien dilakukan dua tahap tindakan. Pertama, dilakukan Bedah Sinus Endoskopik Fungsional (BSEF) dan polipektomi dalam anestesi umum, dan empat bulan kemudian pasien menjalani septorinoplasti untuk rekonstruksi wajah. Kesimpulan: Polip hidung pada kasus ini kemungkinan terkait dengan sindrom Woakes, ditandai dengan pelebaranpyramid hidung yang membutuhkan tindakan operasi fungsional dan estetika.Kata kunci: sindroma Woakes, polip hidung, Bedah Sinus Endoskopik Fungsional, Septorinoplasti.
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Lund, V. J. "Fortnightly Review: Diagnosis and treatment of nasal polyps." BMJ 311, no. 7017 (November 25, 1995): 1411–14. http://dx.doi.org/10.1136/bmj.311.7017.1411.
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Valera, F. Cardoso Pereira, C. Scrideli, R. Queinoz, L. Gonzaiga Tone, and W. T. Anselmo-Lima. "NF-kappaB expression predicts clinical outcome for nasal polyposis." Rhinology journal 48, no. 4 (December 1, 2010): 408–41. http://dx.doi.org/10.4193/rhino09.161.
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OBJECTIVE: To correlate clinical prognosis to the expression of p65, c-Fos, GRalpha and GRbeta in patients with nasal polyps. METHODS: A biopsy was obtained at the first evaluation for patients with nasal polyps (20), and at rhinoplasty for control mucosa (8). Patients with nasal polyps were treated with glucocorticoids and followed for at least 30 months. The expression of each gene (p65, c-Fos, GRalpha and GRbeta) was determined by Real Time-PCR and correlated to clinical outcome. The indication for surgery was considered the end-point of resistance to glucocorticoid therapy. RESULTS: Patients with nasal polyps presented a higher expression of p65 (P<0.05), and a lower expression of GRalpha (P<0.0001), and of GRalpha/GRbeta relation (P<0.0001) than controls. The nasal polyps patients with higher expression of p65 correlated with a poorer response to glucocorticoids (P<0.05), with a four-fold higher risk for surgery to control symptoms. CONCLUSION: Patients with nasal polyps presented higher gene expression of p65, and a reduced expression of GRalpha and of GRalpha/GRbeta relation than controls. Higher p65 (NFkappaB) expression at diagnosis was also associated to a worst response to medical treatment, suggesting this could be considered as one mechanism of cell resistance to glucocorticoid treatment in patients with nasal polyps.
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Pollard, K., and D. A. Carter. "A case of nasal glioma and neurofibromatosis A new association." Journal of Laryngology & Otology 101, no. 5 (May 1987): 497–99. http://dx.doi.org/10.1017/s0022215100102075.
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A man of 25 with von Recklinghausen's neurofibromatosis (VR) developed nasal polyps. Subarachnoid haemorrhage occurred shortly after surgical excision and he died 9 weeks later. Post-mortem examination showed chronic hydrocephalus due to aqueduct stenosis. Histologically the polyps were a nasal glioma, a forme fruste of anterior encephalocoele not previously associated with VR, though other cranial defects are well recognized. Nasal glioma should be considered in the differential diagnosis of nasal lesions in VR.
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Perić, Aleksandar, Danilo Vojvodić, Lidija Zolotarevski, and Aneta Perić. "Nasal Polyposis and Fungal Schizophyllum Commune Infection: A Case Report." Acta Medica (Hradec Kralove, Czech Republic) 54, no. 2 (2011): 83–86. http://dx.doi.org/10.14712/18059694.2016.25.
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We present a rare case of eosinophilic fungal rhinosinusitis with nasal polyps in a 32-year-old woman caused by basidiomycete fungusSchizophyllum commune. Diagnosis was done by the endoscopic nasal examination, computed tomography (CT) of the paranasal sinuses, the histopathological examination of polyps, the presence of eosinophils and fungal hyphae in nasal mucus and by the detection ofS. communeby culture. The patient was successfully treated by combination of oral itraconazole and topical corticosteroid therapy combined with surgery. The pathogenesis and diagnosis of allergic fungal rhinosinusitis are also discussed.
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Mollin, Edward, and Andrzej Skorek. "Diagnostic and therapeutic difficulties in the case of angiomatous polyps of the paranasal sinuses. Case presentation." Polski Przegląd Otorynolaryngologiczny 7, no. 4 (December 12, 2018): 1–5. http://dx.doi.org/10.5604/01.3001.0012.7838.
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Preface: angiomatous nasal type polyps (SAP ‒ sinonasal angiomatous polyp) are benign lesions. The clinical and radiological picture of SAP may suggest other diseases of the nose and paranasal sinuses. Diagnostic imaging is based on computed tomography and magnetic resonance. SAP treatment involves their surgical removal. A case report: he aim of the study is to present diagnostic and therapeutic difficulties in a 17-year-old female patient with an inflammatory polyposis of the angiomatous of the paranasal sinuses. The course of disease, diagnostic difficulties and its treatment are presented. No complications were observed during hospitalization and in the postoperative period. Summary: SAP is one of the types of nasal polyps characterized in the histological picture of vascular proliferation with the presence of blood clots. Accurate diagnostic and histological diagnostics allow to determine the final diagnosis and differentiation of SAP with nasal and sinus hyperplasia.
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Wenig, Bruce M., and CAPT Dennis K. Heffner. "Respiratory Epithelial Adenomatoid Hamartomas of the Sinonasal Tract and Nasopharynx: A Clinicopathologic Study of 31 Cases." Annals of Otology, Rhinology & Laryngology 104, no. 8 (August 1995): 639–45. http://dx.doi.org/10.1177/000348949510400809.
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We report the clinicopathologic features of 31 cases of respiratory epithelial adenomatoid hamartomas occurring in the nasal cavity, paranasal sinuses, and nasopharynx. The patients included 27 men and 4 women ranging in age from 27 to 81 years (median, 58 years). Symptoms included nasal obstruction, nasal stuffiness, deviated septum, epistaxis, and chronic (recurrent) rhinosinusitis. The symptoms occurred over various time periods from as short as a few months to up to 8 years in duration. Physical examination identified the presence of a polypoid mass lesion(s), most often identified in one or both nasal cavities (n = 22). Within the nasal cavity the most common site of occurrence was the nasal septum, particularly along its posterior aspect. Other areas within the nasal cavity were also involved, as were the ethmoid sinus, frontal sinus, and nasopharynx. The gross appearance of the mass lesions suggested a diagnosis of an inflammatory polyp, but because of subtle differences, including frequent occurrence along the nasal septum and a more indurated quality, these polyps were considered unusual for the typical inflammatory polyps. Histologically, these lesions were characterized by a prominent glandular proliferation lined by ciliated respiratory epithelium originating from the surface epithelium. The differential diagnosis of these adenomatoid hamartomas includes schneiderian papillomas of the inverted type and adenocarcinomas. Diagnostic misinterpretations may result in untoward surgical intervention. Limited but complete surgical resection was the treatment of choice, following which there were no instances of recurrent disease.
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Øie, Marte Rystad, Sarah Bettina Dahlslett, Malcolm Sue-Chu, Anne-S. Helvik, Sverre Karmhus Steinsvåg, and Wenche Moe Thorstensen. "Rhinosinusitis without nasal polyps in COPD." ERJ Open Research 6, no. 2 (April 2020): 00015–2020. http://dx.doi.org/10.1183/23120541.00015-2020.
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The validity of the united airway disease concept for rhinosinusitis (RS) and chronic obstructive pulmonary disease (COPD) has been questioned because of methodological limitations in previous studies. In this study we investigated the prevalence of RS without nasal polyps (RSsNP) and the severity of sinonasal symptoms in COPD and a corresponding control group. We also evaluated the diagnostic accuracy of these symptoms for RSsNP in COPD. 90 COPD patients and 93 controls were included in an observational cross-sectional study where globally accepted diagnostic criteria of RS and COPD (EPOS 2012 and GOLD) were incorporated; symptomatic and endoscopic criteria for the diagnosis of RS, and spirometry with reversibility for diagnosis of COPD. RS symptoms were identified by responses to the sinonasal outcome test (SNOT-22), nasal endoscopy identified signs of sinonasal disease and discriminated between RS with and without nasal polyps, and visual analogue scales (VAS) rated the severity of sinonasal symptoms. We found RSsNP in 51% of our COPD patients which is threefold greater than in the control group (p<0.001). Nasal discharge (72%) and nasal obstruction (62%) were the two most frequently reported symptoms in COPD. The diagnostic accuracy for RSsNP is better for the composite VAS for rhinological symptoms than for facial symptoms. We conclude that RSsNP is present in 51% of our COPD patients, which is significantly more prevalent compared to a corresponding control group. These results suggest that COPD is associated with RS.
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Shah, Rameez. "Importance of Histopathology in Diagnosis of Unilateral Nasal Polyps." Clinical Medicine Research 3, no. 4 (2014): 87. http://dx.doi.org/10.11648/j.cmr.20140304.11.
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Guo, Michael, Fahad Alasousi, Christopher Okpaleke, Al-Rahim Habib, and Amin Javer. "Prognosis of Chronic Rhinosinusitis With Nasal Polyps Using Preoperative Eosinophil/Basophil Levels and Treatment Compliance." American Journal of Rhinology & Allergy 32, no. 5 (August 16, 2018): 440–46. http://dx.doi.org/10.1177/1945892418793523.
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Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have a high risk of disease recurrence and revision surgery. The ability to predict a polyp recurrence in this patient population is critical in order to provide adequately tailored postoperative management. Objective We aim to explore the role of appropriate postoperative care in the prognosis of CRSwNP patients in relation to preoperative eosinophil and basophils levels. Methods This was a retrospective case series; data were collected for 102 CRSwNP patients over a period of 15 months after surgery. Baseline eosinophil and basophil levels were compared between patients with and without polyp recurrences. The analysis was then stratified based on clinical diagnosis, comorbidities (atopy, asthma, and aspirin allergy), a single versus multiple episodes of sinonasal polyp recurrences, and medication adherence. Results Of the 102 included patients, 65 (63.7%) of the patients experienced no recurrences, 26 (25.5%) experienced a single episode of recurrence, and 11 (10.8%) experienced multiple recurrences. Mean baseline eosinophil count and percentage of total white blood cells were significantly higher in the multiple recurrences group (0.70 × 109/L and 10%) compared with the no recurrences group (0.36 × 109/L and 5%). Adherence to prescribed medical therapy prior to the first episode of recurrence was significantly lower for the single exacerbations group (42.3%) than the multiple recurrences group (88.9%). Conclusions Patients with multiple recurrences of nasal polyps had significantly higher baseline eosinophil counts and significantly higher medication adherence compared to single exacerbations of nasal polyps. Single exacerbations may not reflect true failures of surgery but rather a failure of postoperative medical care. Basophil levels were inadequate to predict polyp recurrence rates.
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Baruah, Shruti, Pratibha Vyas, and Arpit Srivastava. "CT scan vs nasal endoscopy findings in the diagnosis of chronic rhinosinusitis: our experience." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 3 (April 26, 2019): 739. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20191741.
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<p class="abstract"><strong>Background:</strong> Diagnostic nasal endoscopy and CT imaging are both widely used essential diagnostic tools for chronic rhinosinusitis (CRS). This study analyses their individual roles in the management of CRS as well as the degree of correlation between the two.</p><p class="abstract"><strong>Methods:</strong> A prospective observational comparative study was conducted in the Department of Otorhinolaryngology, Mahatma Gandhi Hospital, Jaipur from January, 2017 to June, 2018 on a sample size of 201 patients diagnosed with chronic rhinosinusitis, as per AAOHNS guidelines. DNE and CT PNS were done for all patients enrolled in the study, the findings of each were correlated and their individual sensitivity and specificity for each variable was calculated. </p><p class="abstract"><strong>Results:</strong> On Comparing CT findings with diagnostic nasal endoscopic findings, Polyps were seen in 91 patients’ CT scans as opposed to 124 on DNE. B/L Polyps on CT imaging vs bilateral ethmoidal polyps visualized during DNE revealed a highly significant “P” value; whereas for antrochoanal polyps or unilateral polyps there was no significant difference. Maxillary sinus involvement is the most commonly observed finding in CT scan of PNS in CRS while deviated nasal septum is the most common finding on a diagnostic nasal endoscopy, seen in 60.7%. For anatomical variants like concha bullosa and paradoxical middle turbinate, no significant difference was seen.</p><p class="abstract"><strong>Conclusions:</strong> CT scans and DNE are both key pre-operative diagnostic tools for patients of CRS and both are complementary to each other in detecting type and extent of pathology.</p>
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Asimakopoulos, P., I. Hathorn, H. Monaghan, and A. T. Williams. "Incidence of neoplasia in patients with clinically suspicious nasal lesions and the value of computed tomography imaging in diagnosis." Journal of Laryngology & Otology 129, no. 3 (February 16, 2015): 254–60. http://dx.doi.org/10.1017/s0022215115000213.
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AbstractBackground:There is no consensus as to whether all routine bilateral polypectomy specimens should be sent for formal histopathological diagnosis to exclude underlying neoplastic pathology. This study assessed the necessity for histopathological investigation as routine practice in cases of bilateral and unilateral nasal lesions by estimating the incidence of unexpected pathologies. It also evaluated the ability of computed tomography to predict histopathological diagnosis in patients with unilateral nasal lesions.Methods:A retrospective analysis was conducted of 98 patients undergoing nasal polypectomy over a 12-month period.Results:Five of 23 patients with a unilateral lesion on nasendoscopy had inverted papillomas on histopathological examination. None of the 75 patients with clinically bilateral lesions on nasendoscopy showed evidence of neoplasia on histopathological examination. Patients with inverted papillomas had significantly lower total Lund–Mackay scores than those with bilateral polyps. Asymmetry scores of inverted papilloma patients were significantly higher compared to both bilateral and unilateral polyps patients.Conclusion:The results suggest that histopathological diagnosis is only necessary in unilateral lesion patients as no unexpected histopathological diagnoses were made in bilateral lesion patients. Computed tomography imaging may have a role in predicting histopathological diagnosis by demonstrating asymmetry and less overall sinus opacification in patients with neoplastic lesions.
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Costa, Patrícia, Gabriel Gomes, Tania Folescu, Renata Cohen, and Debórah Silveira. "Diagnosis of cystic fibrosis in patient with nasal polyps: case report." Residência Pediátrica 9, no. 3 (2019): 326–29. http://dx.doi.org/10.25060/residpediatr-2019.v9n3-27.
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Singh, V. P., Pankaj Arora, Alessia Rubini, Chetan Bansal, and Arvind Varma. "Ectopic pituitary adenoma: a rare and unexpected diagnosis, clinical presentation and review of the literature." International Journal of Otorhinolaryngology and Head and Neck Surgery 6, no. 11 (October 23, 2020): 2146. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20204651.
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<p>Nasal obstruction can be caused by many causes. Most common cause of nasal obstruction is deviated nasal septum followed by nasal masses. Nasal masses can be polyps, tumors or foreign bodies. We are presenting a case of ectopic pituitary tumor as a as cause of nasal obstruction along. Ectopioc pituitary tumors are rare tumors and can present in nasal cavity causing nasal symptoms. They can cause unilateral or even bilateral nasal obstruction depending on their spread in nasopharynx and nose and should be kept in mind while treating a case of nasal masses.</p>
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Pol, Shashikant A., Surinder K. Singhal, Nitin Gupta, and Jyotika Sharma. "Antrochoanal polyp in a six year old child: a rare presentation." International Journal of Otorhinolaryngology and Head and Neck Surgery 6, no. 6 (May 22, 2020): 1195. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20202224.
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<p class="abstract">Antrochoanal polyp is a benign solitary sinonasal polyp arising within the maxillary sinus and extending into nasopharynx via sinus ostium. It is reported commonly in young adults mainly in 3rd to 5th decades. Antrochoanal polyp accounts 4% to 6% of sinonasal polyps in general population and approximately 33% in paediatric population. Here we are reporting a case of antrochoanal polyp in just six year child because of its relative rarity. We report a case of six year old female patient who presented with left sided nasal obstruction for 3 months. It was associated with nasal discharge. Anterior rhinoscopy showed presence of a single polypoidal mass filling left nasal cavity, posterior extent of the mass could not be assessed clinically due to small age of the patient. Non-contrast computed tomography of nose and paranasal sinuses was done to see the exact extent of the mass. The mass was removed completely by endoscopic approach and histopathologically confirmed as antrochoanal polyp. Antrochoanal polyp should be kept in differential diagnosis when a patient comes with unilateral nasal obstruction and discharge. Though it is commonly seen in young adults, rarely, children younger than 10 years of age can be affected. Complete endoscopic excision is necessary to avoid recurrence.</p>
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Al-Assal, Khalid Dahham Radi, Ahmed Abass Mossa Al-Khafaji, and Jawad AbdulKadhum Beden Thuhabat. "Comparative Study between Nasal Endoscopic Findings and Nose and Paranasal Sinus Computerized Tomography in diagnosis of Nose and Paranasal Sinuses Diseases." AL-Kindy College Medical Journal 16, no. 2 (December 30, 2020): 35–38. http://dx.doi.org/10.47723/kcmj.v16i2.264.
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Background: Nasal obstruction is common in otorhinolaryngology outpatient visitors. The diagnosis of such compliant is by history, clinical examination and diagnostic procedures. Nasal endoscopy and computerized tomography scan are common diagnostic investigations. Nasal obstruction is either anterior or posterior (nasal septal deviations, hypertrophied turbinate pathological cyst, polyps, mass etc), or postnasal obstruction (hypertrophied turbinate, adenoid hypertrophy, nasopharyngeal cyst or nasopharyngeal tumors).
Aim of study: Prospective study to compare endoscopic finding and computerized tomography of nose, paranasal sinuses and postnasal space as diagnostic methods for nasal obstruction and other nose, paranasal sinuses and post nasal space diseases.
Subjects and methods: 80 patients with nasal obstruction between the age of 12-60 years old.All patient were examined by nasal endoscopy (rigid or flexible) under local anaesthesia (10 % xylocaine spray and cotton wicks soaked with ephidren 0.5 % and xylocaine 2 % ) and nose, paranasal sinuses and post nasal space C.T. scan,weather without contrast or with it, bone window or soft tissue according to the lesion.
Results: Both nasal endoscopy and C.T. scan were an important tools for diagnosis of nasal diseases and complementary to each other.
Conclusion: Endoscopic examination of the nose gives a real view of nasal structures, postnasal space, any mass or polyps present.Computerized tomography is an accurate diagnostic method of the Nose, paranasal sinuses and post nasal spaces anatomical variations or pathologies.
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Lee, Young Uk, Jong Dae Suh, Eun Kyung Youn, Jung Hyeon Kim, and Kyeong Jae Jung. "CT Evaluation of Nasal Cavity Masses: Differential Diagnosis between Nasal Polyps and Their Mimics." Journal of the Korean Radiological Society 31, no. 4 (1994): 633. http://dx.doi.org/10.3348/jkrs.1994.31.4.633.
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Kabekkodu, Sushmitha, Suja Sreedharan, Kirti Gupta, and Nirupama Murali. "Nasal Polyposis in mucopolysaccharidosis type II." BMJ Case Reports 14, no. 3 (March 2021): e238778. http://dx.doi.org/10.1136/bcr-2020-238778.
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Mucopolysaccharidosis (MPS) type II is a rare multisystem disorder resulting from the accumulation of breakdown products of glycosaminoglycans in the body tissues. Many patients with this disease undergo ENT (ear, nose and throat) surgeries such as adenotonsillectomy and tympanocentesis at a very early age, much before the diagnosis of MPS. Nasal polyposis is a rare occurrence, with only one case of MPS II with polyposis reported in the literature. We present a patient who presented with recurrent nasal polyposis from the age of 2 years. Hale’s colloidal iron was used to stain these ‘nasal polyps’, which revealed that they are, in fact, mucopolysaccharide-laden sinonasal mucosa prolapsing into the nasal cavities. We believe this is the first time that this stain has been used to stain nasal polyps in MPS. In addition to the histopathological peculiarities of these nasal masses, we also discuss the natural history of nasal polyposis in MPS II.
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Ferguson, Stephanie, Ken C. Smith, Claire E. Welsh, and Melanie J. Dobromylskyj. "A retrospective study of more than 400 feline nasal biopsy samples in the UK (2006–2013)." Journal of Feline Medicine and Surgery 22, no. 8 (October 21, 2019): 736–43. http://dx.doi.org/10.1177/1098612x19881847.
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Objectives The main objective of this study was to utilise a large database from a UK-based, commercial veterinary diagnostic laboratory to ascertain the prevalence of different forms of nasal disease within the feline population. Further objectives included using this database to detect any breed, sex or age predilections, or associations between the degree of brachycephalism, and the different conditions diagnosed. Methods Records from the laboratory were searched for feline submissions received between 31 May 2006 and 31 October 2013. For all samples taken from the nasal cavity, the diagnosis was recorded together with the breed, age, sex and neuter status of the cat, whether the clinical presentation was uni- or bilateral and whether a nasal discharge was present. Pedigree breeds were further subclassified according to skull conformation into brachycephalic, mesocephalic and dolichocephalic. Logistic regression models were constructed to assess the adjusted magnitude of association of significant risk factors with each disease, and each disease was also used as a potential independent risk factor for each other disease. Results The most prevalent nasal disease was rhinitis, followed by neoplasia and polyps. The most commonly diagnosed neoplasm was lymphoma, followed by adenocarcinoma and undifferentiated carcinoma, with benign tumours being very uncommon. No significant association was found between skull conformation and nasal diseases. The only statistically significant association was polyps being more likely to arise in younger male cats, with a mesocephalic skull conformation and no nasal discharge. Conclusions and relevance No significant association was found between skull conformation and nasal diseases, contrary to what might be expected. The only significant association found between any of the potential risk factors and various forms of nasal disease was polyps being more likely to arise in younger cats; other identified associations are only likely to be weak.
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Guleria, Trilok C., Shobha Mohindroo, Narender K. Mohindroo, and Ramesh K. Azad. "Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India." An International Journal Clinical Rhinology 10, no. 2 (June 24, 2017): 93–98. http://dx.doi.org/10.5005/jp-journals-10013-1316.
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ABSTRACT Introduction: Nasal masses are common finding in the ear, nose, and throat outpatient department. Most patients present with complaints of nasal obstruction. A sinonasal mass can have various differential diagnoses. They may be congenital, inflammatory, neoplastic (benign or malignant), or traumatic in nature. A careful histopathological examination is necessary to decide the nature of any particular lesion. Materials and methods: The retrospective study was carried out between January 2011 and December 2013. A total of 185 cases diagnosed with masses of the nasal cavity, paranasal sinuses, and nasopharynx were included. Data from histopathological records were retrieved to confirm the diagnosis. Observations: Among 185 cases, 75% were non-neoplastic and 25% were neoplastic. Among neoplastic masses, 57% were benign and 43% were malignant. The age of presentation ranged from first to eighth decade of life (mean age 37.74 years). The lesions had a stronger predilection for males (1.68:1). Among non-neoplastic lesions, nasal polyp was the commonest lesion followed by ethmoidal mucocele (1.44%) and lupus vulgaris (0.72%). Among benign lesions, inverted papilloma (30.77%) and nasopharyngeal angiofibroma (30.77%) were the commonest followed by capillary hemangioma (15.38%), osteoma (7.68%), nasopharyngeal lymphoepithelioma (3.85%), chondroma (3.85%), pleomorphic adenoma (3.85%), and schwannoma (3.85%). Squamous cell carcinoma (40%) was the commonest malignant neoplastic lesion observed followed by adenoid cystic carcinoma (20%), malignant melanoma (15%), nasopharyngeal carcinoma (10%), esthesioneuroblastoma (10%), and non-Hodgkin lymphoma (5%). Conclusion: Among the noninflammatory lesion, nasal polyp is the commonest lesion. Nasal polyps are more common in hilly area may be due to exposure to pine pollens. There is no difference in the histopathological profile of benign and malignant lesions. How to cite this article: Guleria TC, Mohindroo S, Mohindroo NK, Azad RK, Kumar A. Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India. Clin Rhinol An Int J 2017;10(2):93-98.
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Shin, Seung-Heon, Mi-Kyung Ye, and Young-Ho Lee. "Fungus Culture of the Nasal Secretion of Chronic Rhinosinusitis Patients: Seasonal Variations in Daegu, Korea." American Journal of Rhinology 21, no. 5 (September 2007): 556–59. http://dx.doi.org/10.2500/ajr.2007.21.3065.
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Background The role of fungi in the pathogenesis of chronic rhinosinusitis (CRS) is being increasingly recognized. The presences of fungal spores are a necessary condition for fungal sinusitis, and fungal spore counts vary widely, both geographically and seasonally. The aim of this study was to characterize fungal seasonal variation in the nasal cavity of CRS patients and to compare it with histologic types of nasal polyps. Methods One hundred eight patients with a clinical diagnosis of CRS with polyps were enrolled in this study for 1 year. Nasal secretions were obtained by aspiration and cultured to identify fungi. Nasal polyps were divided into four histologic types: eosinophilic, fibroinflammatory, seromucinous, and atypical. Results Positive cultures for fungi were obtained in 60 of 108 (63.0%) CRS patients, and 28 of 45 (62.2%) normal volunteers. Fungus culture rates were higher during summer and fall. Cladosporium, Aspergillus, Alternaria, and Penicilium were frequently isolated from CRS patients and normal volunteers. The most common histologic type was the fibroinflammatory type (60.2%), although in the summer and fall the proportion of the eosinophilic type increased. Conclusion Fungi were commonly cultured during a hot and humid environment, during summer and fall, and cultured organism types were found to be seasonal dependent. Histologic types of nasal polyps appear to be associated with fungal culture rate, organism type, and seasonal variations.
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Khan, Amjad Ali, Abdul Shaheed Asghar, Muhammad Ishaq, and Israr Ahmed Akhund. "POLYPOID NASAL MASSES;." Professional Medical Journal 24, no. 11 (November 3, 2017): 1713–18. http://dx.doi.org/10.29309/tpmj/2017.24.11.641.
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Objectives: The purpose of this study is firstly to signify the occurrence ofunusual nasal polypoid masses by analyzing their histopathological spectrum and to be on thelookout for them. Secondly to highlight the fact that nasal polypoid masses should not be takenlightly as they may be representing an underlying grave pathological process meriting urgentmedical advice. Study Design: Retrospective/observational study. Setting: Charsada TeachingHospital affiliated with Jinnah Medical College Peshawar. Period: March 2010 to March 2015.Methods: In this study, all the surgical pathology cases with clinical diagnosis of nasal polypswith no suspicion for malignancy were retrieved from archives of Charsada Teaching Hospitalaffiliated with Jinnah Medical College Peshawar. The slides and diagnoses of all the retrievedcases were reviewed. The number of cases for each diagnostic category were recorded andanalyzed according to the non-neoplastic, neoplastic and their subcategories. Results: Thereview of cases from March 2010- March 2015 showed that most of the polypoid masses werenon-neoplastic, while only few were neoplastic. Of all the non-neoplastic masses, inflammatory/allergic polyps were much more common followed bypolyps with fungal infections andeosinophilic angiocentric fibrosis. Amongst the neoplastic masses, benign tumors were morecommon than the malignant. The benign masses comprised of hemangioma, angiofibroma,inverted papilloma and schwannoma. The malignant nasal masses constituted one case eachof polypoid extraskeletal Ewings sacoma, plasmacytoma, non-Hodgkin lymphoma and renalcell carcinoma. Conclusions: Awareness about the occurrence of the usual and unusualentities in the nasal cavities needs to be increased. Important diagnostic categories requiringurgent management include polyps with invasive fungal infection, inverted papilloma and allmalignant cases. Therefore, all unilateral nasal cavity masses with frequent epistaxis, pain orbone erosions should be submitted for histopathological examination.
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Lapusneanu, Lucian, Cristina Andrei, Daniela Mihalache, and Luciana Lapusneanu. "Woakes’ syndrome: Case report." Romanian Journal of Rhinology 11, no. 42 (April 30, 2021): 81–87. http://dx.doi.org/10.2478/rjr-2021-0015.
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Abstract Woakes’ syndrome is a rare entity, defined as severe recurrent chronic rhinosinusitis with nasal polyps, which has as a consequence the deformation of the nasal pyramid, produced by the continuous pressure and the inflammation maintained by the size of the polyps. This paper reviews the main features of Woakes’ syndrome by describing a clinical case. The patient presented to the ENT Outpatient Clinic for aggravation of an obstructive nasal respiratory syndrome, associated with rhinor-rhea, headache, anosmia and deformity of the nasal pyramid. The ENT clinical examination, the nasal endoscopic examination and the craniofacial CT scan established the diagnosis of Woakes’ syndrome. Functional endoscopic sinus surgery was performed. The follow-ups performed at 10 days and later, a month after surgery, showed a favourable evolution, without signs of local recurrence and a narrowing of the nasal pyramid compared to the preoperative moment. Proper management and proper adherence to the therapeutic protocol are factors that can prevent the onset of this syndrome.
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Parham, D. M., and N. D. Padgham. "Post-surgical necrotizing palisading granuloma of the nose." Journal of Laryngology & Otology 107, no. 7 (July 1993): 656–57. http://dx.doi.org/10.1017/s0022215100124016.
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Velegrakis, S., N. Chatzakis, E. Prokopakis, M. Papadakis, E. Panagiotaki, M. Doulaptsi, and A. Karatzanis. "A Case Report of Aggressive Chronic Rhinosinusitis with Nasal Polyps Mimicking Sinonasal Malignancy." Case Reports in Otolaryngology 2019 (June 9, 2019): 1–5. http://dx.doi.org/10.1155/2019/3725720.
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Introduction. Cases of extensive nasal polyps rarely occur and may mimic more aggressive lesions of the nose and paranasal sinuses. A case of extensive nasal polyposis with unusually aggressive behavior and its management is presented. Presentation of Case. A 27-year-old male patient visited the emergency department of a tertiary center, complaining of recurrent episodes of epistaxis. The patient presented with a large polypoid lesion protruding from the right nostril and producing asymmetry of the face. Diagnostic imaging illustrated a lesion of the right maxillary sinus producing excessive bone remodeling and extension into neighboring structures in every direction. Fine limits were noted, however, with no invasive characteristics. Biopsy under local anesthesia was performed, showing findings consistent with nonspecific inflammation. Open surgery through a lateral rhinotomy under general anesthesia was performed, and the mass was readily mobilized and removed. No macroscopic invasion of neighboring structures was noted. Permanent histology confirmed the diagnosis of nasal polyposis. Postoperative follow-up has shown no evidence of recurrence after 12 months. Conclusion. Nasal polyps do not typically expand in an aggressive manner, producing bone resorption or extending into neighboring structures. However, nasal polyposis should be included in the differential diagnosis of nasal tumors with such behavior.
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Lourenço, Edmir Américo, and Luís Henrique Chechinato Costa. "Nasal septal pediculate carcinoma in situ: differential diagnosis." Sao Paulo Medical Journal 114, no. 4 (August 1996): 1216–19. http://dx.doi.org/10.1590/s1516-31801996000400004.
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Pediculated lesions of the nasal cavities are relatively common in daily practice, and include inflammatory polyps, benign tumors (papillomas being the most common), malignant tumors, and specific processes, such as polypoid rhinosporidiosis. The authors describe a female patient with a warty, pediculated, and asymptomatic lesion in the nasal septal mucosa. The anatomo-pathological exam showed this to be a"carcinoma in situ." The few bibliographic citations report only an association between the tumor and contact with wood dust, such as oak, ebony and beech. The patient was not exposed to these elements. It is important to emphasize the routine performance of a complete otolaryngological exam for patients seeking out specialists, in order to detect potentially malignant lesions whose early removal would permit a complete cure.
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Nepal, A., ST Chettri, RR Joshi, and S. Karki. "Benign Sinonasal Masses: A Clinicopathological and Radiological Profile." Kathmandu University Medical Journal 11, no. 1 (September 9, 2014): 4–8. http://dx.doi.org/10.3126/kumj.v11i1.11015.
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Background Benign nasal and paranasal sinus masses are commonly encountered in clinical practice. Though benign, certain nasal polyps, fungal sinusitis, hemangiomas and fibro-osseous tumors can present with locally destructive features and deformities, mimicking malignancies at once. Objective This study was carried out to recognize the great variety of benign nasal lesions and their frequency in our region. Methods A retrospective chart analysis of cases presenting as mass in nose and paranasal sinus that underwent surgery over three years duration at our institute was done. A provisional diagnosis was made after clinical assessment and radiological investigations, but the final diagnosis was established after histopathological examination. Results A total 331 cases presented as masses in nose and paranasal sinus presented during the period. The clinicopathological examination aided by endoscopic and imaging studies revealed the non neoplastic benign masses in 293 and neoplastic masses in 38. Polyps were the commonest lesions constituting 70% cases followed by rhinosporidiosis in 10%. Fungal sinusitis, squamous papillomas, hemangiomas and inverted papillomas were found to be in order of 4.5%, 4%, 3.5% and 3% respectively. Rare cases like “rhino-oto-cereberal” form of mucormycosis, angiomyoma, and psammomatoid ossifying fibroma were also observed in the study. Conclusion Most of the nasal polyps/fungal sinusitis can be diagnosed clinically. However many a times Computer tomography (CT) scan and biopsy are necessary to differentiate them from each other and treatment plan. Certain benign tumors have high potential for malignant transformation while others can present with locally destructive features and deformities. DOI: http://dx.doi.org/10.3126/kumj.v11i1.11015 Kathmandu University Medical Journal Vol.11(1) 2013: 4-8
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Khot, Sunil N., G. Priyadarshini, and Prajakta Patil. "Benign lesions of the nose: a comprehensive study." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 1 (December 25, 2018): 106. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20185295.
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<p class="abstract"><strong>Background:</strong> Benign lesions of the nasal cavity represent a diverse group of pathologies. Furthermore, each of these disorders may present differently in any given patient as pain and discomfort, epistaxis, headaches, vision changes, or nasal obstruction.</p><p class="abstract"><strong>Methods:</strong> This study was carried out in a tertiary care center in India from October 2016 to March 2018. A total of 80 patients of age 10 years to 80 years were included. Detailed history and complete ENT examination including radiological studies was done. Patients were subjected to diagnostic nasal endoscopy and biopsy followed by histopathological examination. Depending on the diagnosis, medical or surgical treatment or combination of both was administered. </p><p class="abstract"><strong>Results:</strong> In present study the commonest presenting complaint was found to be nasal blockage found in 76% of cases, followed by rhinorrhea in 40%, nasal mass in 30%, epistaxis in 16%, cheek swelling in 5%. Out of 80 benign lesions, polyp was noted in 65 cases, hemangioma in 8 and inverted papilloma in 3 cases. Out of 65 cases of polyps, 52 were antrochoanal, 10 ethmoidal and 3 maxillary. Medical treatment was given in ethmoidal polyp cases, out of which 5 were cured. Most common surgery was polypectomy. Lateral rhinotomy was done in 6 cases</p><p class="abstract"><strong>Conclusions:</strong> Patients with benign lesions of the nose commonly presented in the second and third decade with slight male preponderance.Antrochoanal polyps are most common. Medical treatment works to a certain extent in patients with ethmoidal polyposis and surgery is the mainstay of treatment in the benign lesions of the nose.</p>
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Dimitrijevic, Milovan, Nenad Arsovic, Zoran Dudvarski, and Ivan Boricic. "Giant destructive sinonasal polyposis." Srpski arhiv za celokupno lekarstvo 143, no. 3-4 (2015): 186–89. http://dx.doi.org/10.2298/sarh1504186d.
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Introduction. Authors report their clinical experience in managing a 46-year-old male patient with long lasting nose breathing difficulties caused by nasal obstruction due to a large bilateral tumor masses in both nasal cavities. Case Outline. Physical examination, laboratory and biochemistry analyses, as well as computed tomography showed an inhomogeneous soft-tissue tumor mass completely filling both nasal cavities, maxillary, ethmoidal, sphenoidal, and frontal sinuses on both sides, accompanied by destruction of bony walls of all sinuses. Preoperative histopathology analysis showed a polyp with squamous metaplasia. The gigantic polypoid mass was removed by bicoronal approach to the frontal and ethmoidal sinuses and by direct approach to the maxillary sinuses and nasal cavity. Definite histopathology analysis confirmed the initial diagnosis, but the presence of fungal hyphae in allergic mucus was also observed. Conclusion. Polypoid growth in the nose rarely grow to such gigantic dimensions that it causes destruction of all walls of paranasal sinuses. Considering so far published reports from the literature, the presented case is among the biggest nasal polyps reported until now.
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Allen, HS, J. Broussard, and K. Noone. "Nasopharyngeal diseases in cats: a retrospective study of 53 cases (1991-1998)." Journal of the American Animal Hospital Association 35, no. 6 (November 1, 1999): 457–61. http://dx.doi.org/10.5326/15473317-35-6-457.
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The records of 53 cats with nasopharyngeal disease were examined. Of the cats with nasopharyngeal disease, 49% had lymphosarcoma and 28% had polyps. Clinical signs in these cats were compared to 24 cats with nasal disease alone. Cats with only nasal disease more commonly had historical nasal discharge and sneeze, whereas cats with nasopharyngeal disease more often had stertorous respiration, phonation change, and typically reported less nasal discharge or sneeze. It is important to include nasopharyngeal disease in the differential diagnosis for cats with nasal discharge, sneeze, stertor, or phonation change.
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Sharma, Vinit Kumar, Rohit Sharma, Rajneesh Madhok, Tanu Agarwal, Ashish Mehrotra, and Anisha Kochhar. "Uncommon and Atypical Sinonasal Masses: Diagnostic and Therapeutic Challenges." An International Journal Clinical Rhinology 5, no. 3 (2012): 114–17. http://dx.doi.org/10.5005/jp-journals-10013-1130.
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ABSTRACT Introduction Sinonasal masses are a wide range of pathologies ranging from simple nasal polyps to rare tumors like esthesioneuroblastomas. Early symptoms of all of them are similar to common nasal and sinus problems, hence, producing a delay in diagnosis. Materials and methods All the patients presenting with sinonasal masses in the Department of ENT and Head/Neck Surgery, SRMS Institute of Medical Sciences, Bareilly, were included in the study. The study was carried out between January 2007 and December 2011. Detailed history and ENT examination were recorded. Radiological investigation was carried out in the form of computed tomographic (CT) scan of nose and paranasal sinuses. Final diagnosis was made by histopathological examination either before instituting any form of treatment or by a postsurgical biopsy where surgery was carried out. Immunohistochemistry was done in some cases as deemed necessary by the pathologist. Thus, their modes of presentation, radiological and histopathological profiles were studied along with dilemmas in diagnosis and management. Results A total of 189 nasal masses were observed during this period. Out of which 126 were diagnosed as nasal polyps and were excluded from the study. Thus, 63 uncommon nasal masses were seen in the study period. A large number of uncommon sinonasal masses had atypical presentation and/or presented in an advanced stage to pose a diagnostic and surgical challenge. Endoscopic techniques are becoming a gold standard in surgical resection in most of them. Interdepartmental cooperation is highly essential. How to cite this article Sharma R, Sharma VK, Madhok R, Agarwal T, Mehrotra A, Kochhar A. Uncommon and Atypical Sinonasal Masses: Diagnostic and Therapeutic Challenges. Clin Rhinol An Int J 2012;5(3):114-117.
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Sullivan, William B., Albert T. Linehan, Bettina C. Hilman, Dexter W. Walcott, and Indrani Nandy. "Flexible Fiberoptic Rhinoscopy in the Diagnosis of Nasal Polyps in Cystic Fibrosis." Allergy and Asthma Proceedings 17, no. 5 (September 1, 1996): 287–92. http://dx.doi.org/10.2500/108854196778662219.
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Cottrill, Martha, Ruth Ko, and Harold L. Kim. "The utility of using fiberoptic rhinoscopy in the diagnosis of nasal polyps." Allergy, Asthma & Clinical Immunology 9, no. 1 (2013): 38. http://dx.doi.org/10.1186/1710-1492-9-38.
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Morgan, D. W., and J. N. G. Evans. "Developmental nasal anomalies." Journal of Laryngology & Otology 104, no. 5 (May 1990): 394–403. http://dx.doi.org/10.1017/s0022215100158542.
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AbstractDespite the complex embryological development of the nose and surrounding structures, significant developmental nasal anomalies are rare. We therefore present our experience in the management of such anomalies (excluding choanal atresia) over the past 10 years.Fifty cases were surgically treated; two nasopharyngeal cysts, four hairy polyps, two meningoencephalo coeles, seven gliomata, 20 dermoids, two capillary haemangiomata, four fibromas, one fibromyxyoma, one mucocoele, one granuloma, one lipoma, two nasal aplasias, two nasal clefts and one nasal web. All cases presented with nasal obstruction and/or as a nasal mass. Computerized tomography and magnetic reson ance imaging aided diagnosis determining the extent of intracranial involvement. Various surgical tech niques were used ranging from simple excision to the lateral rhinotomy and Goodman's external rhinoplasty approach. Only five patients (10 per cent) suffered complications; two CSF leaks and three recurrences, all treated successfully.
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Soomro, Aftab Ahmed, Pirbux Magsi, Hamid Ali Sangi, and Haresh Chand. "NON-MALIGNANT LESIONS;." Professional Medical Journal 21, no. 01 (February 10, 2014): 191–96. http://dx.doi.org/10.29309/tpmj/2014.21.01.1936.
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Background: The presence of a mass in the nasal cavity and paranasal sinusesmay seem to be simple problem, but it is very difficult to differentiate clinically from potentiallymalignant tumors. Objective: To evaluate the clinical presentation and histopathologicalfeatures of the non malignant lesions of nasal cavity and paranasal sinuses. Study Design:Prospective descriptive study. Place and duration of study: Study was carried out indepartments of Paediatrics and ENT at Ghulam Muhammad Mahar Medical College HospitalSukkur from Jan 2009 to Dec 2012. Patients and Methods: The study included all cases of nonmalignantmasses of nasal cavity and paranasal sinuses, those attended the Paediatric & ENTdepartment and underwent the surgical intervention. One hundred twenty non-malignant caseswere enrolled for this study. A separate pro-forma was filled to record the cases biodata, history,clinical examination, investigations and histopathological diagnosis. All histopathologicallyproven malignant masses were excluded from the study. Results: Out of 120 cases 78 (65%)were males and 42 (35%) were females, with M:F ratio of 1.8:1. The age of presentation rangedfrom 8 years to 70 years and mean age was 26.3years. Sinonasal masses were found to bebilateral in 20 cases (16.67%), right sided in 65 (54.17%) and left sided in 35 (29.16%) cases. Themain presenting symptoms were nasal blockage 110 (91.66%), nasal discharge 102 (85%),sneezing 60 (50%), hypoinsomnia 36 (30%), epistaxis 24 (20%), headache 20 (18.33%) andmouth breathing 18 (15%) cases. Polyp was the most common lesion in 86 (71.66%) casesobserved in this study. The common histopathological diagnosis was simple inflammatory nasalpolyp in 48 (40%), allergic nasal polyps 30 (25%) and fibroepithelial polyp in 8 (6.7%), invertedpapilloma in 12 (10%), angiofibroma 6 (5%), capillary hemangioma 4 (3.34%) andrhinosporidiosis 4 (3.34%) cases. Conclusions: Sinonasal masses have various differentialdiagnoses and are still thought to be simple problem in our society. There is a need for earlyrecognition and referral to ENT surgeon and need histopathological examination of every massto confirm the diagnosis.
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Ference, Elisabeth H., Sheila R. Reddy, Ryan Tieu, Sohum Gokhale, Siyeon Park, and Jason LeCocq. "Burden of Nasal Polyps in the United States." OTO Open 4, no. 3 (July 2020): 2473974X2095072. http://dx.doi.org/10.1177/2473974x20950727.
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Objective To investigate the clinical and health care burden of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) in the United States. Study Design Retrospective, cross-sectional design with analyses of patient visits from 2 databases. Setting National Ambulatory Medical Care Survey (NAMCS, 2012-2016) and State Ambulatory Surgery and Services Databases (SASD, 2012-2015) in available states. Methods In each analysis, we identified patients (≥18 years old) with a diagnosis of CRSwNP ( ICD-9-CM: 471.x; ICD-10-CM: J33.x) in the visit record during the study period. CRS patients without polyps (CRSsNP: ICD-9-CM: 473.x, ICD-10-CM: J32.x; without CRSwNP codes) were identified for comparison. In the SASD, we focused on visits involving relevant sinus procedures. Outcomes included comorbidities, diagnostic testing, and prescribed medication (NAMCS) and surgery visit characteristics (SASD). Results We identified 2272 NAMCS records from physician offices (183 CRSwNP, 2089 CRSsNP). Most visits were for patients aged <65 years (78.8%, 80.6%) and privately insured (67.7%, 61.5%); CRSwNP visits had a male majority (56.3%, 35.4%). CRSwNP vs CRSsNP visits more often reported asthma (40.2%, 10.3%), allergic rhinitis (14.0%, 8.7%), and congestion (22.0%, 21.1%), with the use of glucocorticoids (21.0%, 17.7%) and nasal allergy medication (26.2%, 10.2%). In the SASD, 427,306 surgery visits were identified (71,195 CRSwNP, 356,111 CRSsNP); demographics were similar to NAMCS. CRSwNP surgeries involved more sinus types (59.3%, 41.4%). Surgeries were mostly elective (>99%) and completed quickly (<2 hours), without perioperative complications (>99%), followed by routine discharge (>91%); follow-up visits were common (14.9%, 13.9%). Conclusion CRSwNP compared to CRSsNP patients have a distinct clinical experience, with moderately higher medication need and more extensive surgery.
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Romano, Fabrizio Ricci, Richard Louis Voegels, Elder Yoshimitsu Goto, Flavio Augusto Passarelli Prado, and Ossamu Butugan. "Nasal contact endoscopy for the in vivo diagnosis of inverted schneiderian papilloma and unilateral inflammatory nasal polyps." American Journal of Rhinology 21, no. 2 (March 1, 2007): 137–44. http://dx.doi.org/10.2500/ajr.2007.21.3003.
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Yfantis, Harry G., Cinthia B. Drachenberg, William Gray, and John C. Papadimitriou. "Angiectatic Nasal Polyps That Clinically Simulate a Malignant Process." Archives of Pathology & Laboratory Medicine 124, no. 3 (March 1, 2000): 406–10. http://dx.doi.org/10.5858/2000-124-0406-anptcs.
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Abstract Background.—Approximately 5% of inflammatory or allergic sinonasal polyps develop extensive vascular proliferation and ectasia with deposition of pseudoamyloid. These so-called angiectatic nasal polyps (ANPs) can grow rapidly and exhibit an aggressive clinical behavior that could simulate malignancy preoperatively. Objective.—To systematically address the differential histologic diagnosis of ANPs. Methods.—We evaluated by light microscopy, immunohistochemistry, and electron microscopy biopsy and resection specimens from 2 large ANPs (8 and 10 cm in diameter) that presented in 2 adult men with life-threatening epistaxis and facial deformity, respectively. Results.—The tumors were firm, lobulated, and covered by smooth, partially ulcerated mucosa. Histologically, clusters of dilated, thin-walled blood vessels embedded in pools of Congo red–negative eosinophilic material, associated with patchy necrosis and atypical stromal spindle cells, were seen. Electron microscopy and immunohistochemistry (CD34, factor VIII) confirmed the endothelial nature of the cells lining the spaces, whereas the atypical stromal cells were classified as myofibroblasts. Conclusions.—These 2 cases represent extreme examples of ANPs that clinically simulate a malignant process. Awareness of the histological features of ANPs should prevent confusion of such lesions with other vascular or spindle cell lesions of the nasopharynx that would require different treatment and carry a different prognosis.
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Egorov, V. I., O. M. Kurbacheva, E. L. Savlevich, K. N. Shachnev, M. E. Dyneva, E. Yu Savushkina, and A. K. Kondakov. "Experience of the center for diagnosis and treatment of chronic rhinosinusitis with nasal polyps." Russian Otorhinolaryngology 19, no. 6 (2020): 8–15. http://dx.doi.org/10.18692/1810-4800-2020-6-8-15.
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Polypous rhinosinusitis (PRS) ranks as one of the most important chronic inflammatory ENT diseases that significantly impair the quality of life. Today, it is known that chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial heterogeneous disease characterized by chronic inflammation of the mucosa of the nasal cavity and paranasal sinuses, leading to the growth of polyps. The interrelation of CRSwNP, atopy and bronchial asthma (BA), their pathogenetic mechanisms, as well as the effect on the severity of the course and the frequency of each other’s relapses, are the subject of study. Data on the role of allergy in CRSwNP are controversial, while the relationship between PRS and BA is not in doubt. Patients suffering from CRSwNP and BA and / or allergic rhinitis (AR) require dynamic monitoring and regular correction of treatment not only by an otorhinolaryngologist, but also by an allergist-immunologist. To this end, since 2016, in Vladimirsky Moscow Regional Research Clinical Institute the Moscow Regional Center for Diagnosis and Treatment of Polypous Rhinosinusitis and Allergic Rhinitis was established, which monitored and treated patients with ARS and comorbid diseases from various medical institutions of the Moscow region. By using a multidisciplinary approach during our work from 2016 to 2020, we managed to achieve a stable remission in most patients, significantly improve their quality of life and reduce the number of surgical interventions.