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Journal articles on the topic 'Nasopharyngitis'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 January 2023

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1

Foucher, Gérard, and François Pillon. "What is nasopharyngitis?" Actualités Pharmaceutiques 55, no. 556 (May 2016): 55–56. http://dx.doi.org/10.1016/j.actpha.2016.03.013.

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2

Heald, Alison, Raymond Auckenthaler, Francois Borst, Olca Delaspre, Daniel Cermann, Lukas Matter, Laurent Kaiser, and Hans Stalder. "Adult bacterial nasopharyngitis." Journal of General Internal Medicine 8, no. 12 (December 1993): 667–73. http://dx.doi.org/10.1007/bf02598283.

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3

Georgitis, John W. "NASOPHARYNGITIS, PHARYNGITIS, AND TONSILLITIS." Immunology and Allergy Clinics of North America 13, no. 1 (February 1993): 109–18. http://dx.doi.org/10.1016/s0889-8561(22)00434-9.

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4

van Dun, Patrick. "Die Nasopharyngitis “nicht-pathologisiert”." DO - Deutsche Zeitschrift für Osteopathie 1, no. 2 (April 2003): 21–22. http://dx.doi.org/10.1055/s-2004-831024.

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5

Krishnan, V., and Shivali Rai. "Sitagliptin induced acute severe nasopharyngitis." International Journal of Basic & Clinical Pharmacology 3, no. 2 (2014): 403. http://dx.doi.org/10.5455/2319-2003.ijbcp20140431.

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6

Brook, Itzhak, and Alan E. Gober. "Dynamics of nasopharyngitis in children." Otolaryngology–Head and Neck Surgery 122, no. 5 (May 2000): 696–700. http://dx.doi.org/10.1067/mhn.2000.105417.

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PURPOSE: Our goal was to characterize the dynamics and bacterial interaction of the aerobic and anaerobic flora of nasal discharge of children at different stages of uncomplicated nasopharyngitis. METHODS AND PATIENTS: Serial semiquantitative nasopharyngeal (NP) and quantitative nasal discharge (ND) cultures were taken every 3 to 5 days from 20 children in whom purulent discharge eventually developed (group 1), and a single culture was obtained from a group of 20 who had only clear discharge (group 2). RESULTS: Aerobic and anaerobic bacteria were isolated from all NP cultures. Bacterial growth was present in 8 (40%) NDs of group 2. Only 7 (35%) of the clear NDs of group 1 showed bacterial growth; the number increased to 14 (70%) at the mucoid stage and 20 (100%) at the purulent stage. It declined to 6 (30%) at the final clear stage. The number of species and total number of organisms increased in the NDs of group 1. Group 1 patients had higher recovery rates of Streptococcus pneumoniae and Haemophilus influenzae in their NP cultures than group 2 patients ( P < 0.05). During the purulent stage, Peptostreptococcus species were isolated in 15 (75%), Fusobacterium species in 10 (50%), Prevotella species in 9 (45%), H influenzae in 8 (40%), S pneumoniae in 6 (30%), and β-hemolytic streptococci in 5 (25%) of group 1 NDs. This was higher than their recovery in the clear stages of both groups and the mucoid stage of group 1. A total of 8 organisms capable of interfering with the growth of potential pathogens were isolated from the NPs of group 1, as compared with 35 from group 2 ( P < 0.001). CONCLUSIONS: The development of purulent nasopharyngitis is associated with the pre-existing presence of potential pathogens and the absence of interfering organisms.
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7

Brook, Itzhak, Alan E. Gober, and Alan E. Gober. "Dynamics of Nasopharyngitis in Children." Otolaryngology–Head and Neck Surgery 122, no. 5 (May 2000): 696–700. http://dx.doi.org/10.1016/s0194-5998(00)70199-9.

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PURPOSE: Our goal was to characterize the dynamics and bacterial interaction of the aerobic and anaerobic flora of nasal discharge of children at different stages of uncomplicated nasopharyngitis. METHODS AND PATIENTS: Serial semiquantitative nasopharyngeal (NP) and quantitative nasal discharge (ND) cultures were taken every 3 to 5 days from 20 children in whom purulent discharge eventually developed (group 1), and a single culture was obtained from a group of 20 who had only clear discharge (group 2). RESULTS: Aerobic and anaerobic bacteria were isolated from all NP cultures. Bacterial growth was present in 8 (40%) NDs of group 2. Only 7 (35%) of the clear NDs of group 1 showed bacterial growth; the number increased to 14 (70%) at the mucoid stage and 20 (100%) at the purulent stage. It declined to 6 (30%) at the final clear stage. The number of species and total number of organisms increased in the NDs of group 1. Group 1 patients had higher recovery rates of Streptococcus pneumoniae and Haemophilus influenzae in their NP cultures than group 2 patients (P > 0.05). During the purulent stage, Peptostreptococcus species were isolated in 15 (75%), Fusobacterium species in 10 (50%), Prevotella species in 9 (45%), H influenzae in 8 (40%), S pneumoniae in 6 (30%), and β-hemolytic streptococci in 5 (25%) of group 1 NDs. This was higher than their recovery in the clear stages of both groups and the mucoid stage of group 1. A total of 8 organisms capable of interfering with the growth of potential pathogens were isolated from the NPs of group 1, as compared with 35 from group 2 ( P > 0.001). CONCLUSIONS: The development of purulent nasopharyngitis is associated with the pre-existing presence of potential pathogens and the absence of interfering organisms.
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8

Fujisaki, Kazuyoshi, Takemoto Shin, Hiroshi Watanabe, and Junichi Yoshida. "Choanal Bleeding Due to Nasopharyngitis." Auris Nasus Larynx 13, no. 3 (January 1986): 169–76. http://dx.doi.org/10.1016/s0385-8146(86)80013-x.

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9

Bezshapochny, Sergey B., Natalia B. Sonnik, Olexander G. Podovzhny, and Oleksiy R. Dzhirov. "Treatment of acute nasopharyngitis in children." OTORHINOLARYNGOLOGY No3(4) 2021, No3(4) 2021 (June 14, 2021): 62–65. http://dx.doi.org/10.37219/2528-8253-2021-3-62.

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Acute nasopharyngitis in children is an inflammation of the nasopharyngeal mucosa. Recently, the use of saline solutions in the pathology of the nose and nasopharynx has become a leader in cleaning the mucous membrane. The main direction of modern pharmacotherapy of pathology of the nose and nasopharynx today is antiinflammatory therapy. There are a sufficient number of studies proving the effectiveness of mometasone furoate nasal spray in the treatment of inflammatory diseases of the nasopharynx in children. Our study examined the clinical efficacy of Etacid in the treatment of acute nasopharyngitis in children. Among the clinical symptoms were considered nasal breathing disorders, nasalness, snoring, cough during sleep. Endoscopy studied stagnant signs in the nasal cavity, nasopharyngeal discharge, enlargement of the pharyngeal tonsil. Proven sufficient clinical efficacy of the drug "Etacid" in the treatment of acute nasopharyngitis.
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10

Indrayani, Ferna. "Pemberian Konseling tentang penyakit Acute Nasopharyngitis (common cold) di Klinik Goa Ria, Makassar." Indonesian Journal of Community Dedication 1, no. 2 (July 31, 2019): 25–28. http://dx.doi.org/10.35892/community.v1i2.182.

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Program kegiatan pengabdian kepada masyarakat yaitu Pemberian Konseling tentang penyakit Acute Nasopharyngitis (Common cold) di Klinik Goa Ria, Makassar. Pemberian konseling merupakan salah satu program yang dirancang untuk diterapkan untuk meningkatkan kesehatan,pengetahun dan kualitas hidup masyarakat.. Secara umum tujuan kegiatan ini yaitu mendorong terjadinya proses perubahan perilaku ke arah yang positif, peningkatan pengetahuan, sikap dan praktik masyarakat secara wajar sehingga masyarakat melaksanakannya secara mantap. Metode yang digunakan dalam pencapaian tujuan adalah metode pemberian edukasi,komunikasi dan informasi tentang terapi Acute Nasopharyngitis (common cold). Hasil dari kegiatan PKM diharapkan pasien yang mengidap penyakit Acute Nasopharyngitis (common cold) menjaga kesehatan.
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11

ANDO, TAMOTSU. "Allergic nasopharyngitis and expiratory NO measurement." Japanese Journal of Pediatric Pulmonology 8, no. 1 (1997): 79–80. http://dx.doi.org/10.5701/jjpp.8.79.

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12

Singh, Saket Kumar, and Vikrant Tripathi. "Effectiveness of Characteristic Keynote Prescription of Homeopathic Medicines in Acute Nasopharyngitis in Paediatric Age Group - A Prospective, Longitudinal Observational Study." International Journal of Advanced Ayurveda, Yoga, Unani, Siddha and Homeopathy 10, no. 1 (January 6, 2021): 609–17. http://dx.doi.org/10.23953/cloud.ijaayush.485.

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Acute Nasopharyngitis is a common upper respiratory tract infection caused by adenoviruses, influenza, rhinovirus, parainfluenza or respiratory syncytial viruses. This prospective, longitudinal, observational study was conducted at SKHMC, Jaipur for a period of 1 year (April 2018 to March 2019), aiming to ascertain the effectiveness of characteristic keynote prescription of homoeopathic medicines in the cases of Acute Nasopharyngitis in paediatric age group. In this study, 59 cases of Acute Nasopharyngitis were treated with homoeopathic medicines prescribed on the basis of totality of the symptoms along with characteristic keynote symptoms. Treatment outcomes were assessed using Common Cold Questionnaire. Out of 59 patients, 36 patients (61.0%) were improved; 15 patients (25.5%) were at status quo, and 08 patients (13.5%) became worse. Maximum patients were found to be in the age group of School Age children (n=27; 45.8%) and Pre-School children (n=21; 35.6%). Males were observed to be affected more as compared to females. Paired ttest was conducted on the CCQ scores obtained before and after treatment and the result showed that p value was < 0.05 & t = 8.404, which was statistically significant which concluded that characteristic keynote prescription of homoeopathic medicines was effective in cases of Acute Nasopharyngitis. Keywords Homeopathy; Common Cold; School age children; Observational study
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13

Sobolev, V. P., V. M. Svistushkin, M. G. Leyzerman, K. R. Magomedov, D. B. Bidanova, and G. N. Budagova. "The efficacy of silver proteinate in the treatment of acute nasopharyngitis." Meditsinskiy sovet = Medical Council, no. 16 (November 14, 2020): 43–49. http://dx.doi.org/10.21518/2079-701x-2020-16-43-49.

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Acute nasopharyngitis is the most common reason for visit a doctor, usually benign, self-limited disease. It is also characterized by a high frequency of complications in children and nonspecific symptoms that require special care from the doctor when examining patients. The clinical and social significance of acute nasopharyngitis is due to their high prevalence, and inadequate treatment leads to a protracted course or to a transition to a chronic one. The relevance of this problem adds to the presence of a large number of various drugs, but not many drugs have evidence-based effectiveness. In the treatment of acute nasopharyngitis local drugs are very important. The drug is a silver proteinate agent with broad antibacterial anti-inflammatory activity. The drug is used to treat infectious rhinitis. This article evaluates the use of a new form of the silver proteinatedrug, the drug is available in the pharmacy, easy to use, long shelf life. This article describes the place of silver proteinate among drugs that help to relieve the symptoms of acute nasopharyngitis and provides data on its effectiveness, safety and features of use in children. The drug can take a worthy place among topical drugs due to its high efficiency in the treatment of acute rhinitis and its possible use at any age.
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14

Belan, E. B. Belan. "Nasopharyngitis: modern approaches to diagnosis and treatment." Pharmateca 1_2020 (March 10, 2020): 76–79. http://dx.doi.org/10.18565/pharmateca.2020.1.76-79.

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15

Brook, Itzhak. "Microbial dynamics of purulent nasopharyngitis in children." International Journal of Pediatric Otorhinolaryngology 67, no. 10 (October 2003): 1047–53. http://dx.doi.org/10.1016/s0165-5876(03)00203-9.

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16

Cardozo, D. M., C. M. Nascimento-Carvalho, A. L. S. S. Andrade, F. R. Souza, and N. M. S. Silva. "The burden of acute nasopharyngitis among adolescents." Archives of Disease in Childhood 91, no. 12 (July 28, 2006): 1045. http://dx.doi.org/10.1136/adc.2006.105718.

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17

Shabaldina, E. V., D. R. Akhtyamov, S. V. Grivtsova, A. V. Shelkovnikov, S. V. Apalko, and A. V. Shabaldin. "Efficacy of herbal medicine in the treatment and immunorehabilitation of preschool children with recurrent acute nasopharyngitis." Voprosy praktičeskoj pediatrii 15, no. 5 (2020): 57–66. http://dx.doi.org/10.20953/1817-7646-2020-5-57-66.

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Objective. To assess the efficacy of herbal medicine (HM) in the treatment and immunorehabilitation of children aged 2–6 years with recurrent acute nasopharyngitis. Patients and methods. This study included 327 children aged between 2 and 6 years; 85 of them were healthy and comprised the control group. The remaining children (n = 242) were divided into two groups by simple calendar randomization: the group receiving HM (n = 133) and the group receiving standard treatment (n = 109). All children have undergone the following examinations 45 days following treatment initiation: clinical examination, complete blood count, measurement of total IgE in peripheral blood, rhinocytogram, assessment of nasopharyngeal lavage and cells from the mucous membrane of the posterior wall of the oropharynx. Nasopharyngeal lavage was tested using enzyme-linked immunosorbent assay (ELISA) for the level of cytokines, including interleukins-1β and 4 (IL-1β, IL-4), interferons-α and -γ (IFNa, IFNy), and tumor necrosis factor-α (TNFα).DNA was isolated from the cells of the pharyngeal mucosa and pharyngeal tonsil and for subsequent analysis of the local biotope: bacteria, viruses, and fungi. Results. We found that HM helped to reduce clinical manifestations of acute nasopharyngitis, reduced local inflammation after treatment, and decreased the concentration of opportunistic flora, including Staphylococcus aureus. Conclusion. The inclusion of HM in the treatment regimen for children with recurrent nasopharyngitis increases treatment efficacy and prevents relapses. Key words: nasopharyngitis, immunorehabilitation
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18

Hosokawa, Seiji, Yuki Yagi, Jun Okamura, Yoshinori Takizawa, and Hiroyuki Mineta. "A Case of Nasopharyngitis due to Chlamydia trachomatis." Practica Oto-Rhino-Laryngologica 103, no. 4 (2010): 317–21. http://dx.doi.org/10.5631/jibirin.103.317.

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19

Bartley, J., and C. Barber. "Treatment of chronic nasopharyngitis with monopolar suction diathermy." Journal of Laryngology & Otology 124, no. 4 (October 14, 2009): 426–27. http://dx.doi.org/10.1017/s0022215109991460.

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AbstractIntroduction:Chronic nasopharyngeal infection is rare. To our knowledge, no effective treatment for this condition has previously been described. This report documents our experience of using suction ablation diathermy in this clinical setting.Method:We performed a prospective review of four patients aged 23–65 years (two men and two women) who presented with chronic nasopharyngitis. Initial medical management consisted of regular saline irrigation plus a 14-day course of doxycycline 100 mg daily, combined with rifampicin 200 mg twice daily. When this proved unsuccessful, patients subsequently received a four-week course of omeprazole 40 mg daily, also unsuccessfully. Given these treatments' lack of success, surgery was undertaken.Results:Following suction diathermy ablation, nasopharyngeal crusting took four to six weeks to settle. After this, all patients ceased to cough up crusts or infected mucus.Conclusions:Chronic nasopharyngitis is uncommon. If medical management fails, suction ablation diathermy is a useful surgical treatment option.
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20

Salman, Salah D. "Acute nasopharyngitis in adults: An independent clinical entity?" American Journal of Otolaryngology 21, no. 6 (November 2000): 409–11. http://dx.doi.org/10.1053/ajot.2000.18880.

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21

Wang, Shumin, Ning Ma, Weilin Zhao, Kaoru Midorikawa, Shosuke Kawanishi, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, and Mariko Murata. "Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma." Mediators of Inflammation 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/9343460.

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Nitrative and oxidative DNA damage plays an important role in inflammation-related carcinogenesis. To investigate the involvement of stem cells in Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, and ALDH1A1) in NPC tissues and NPC cell lines. We also measured 8-nitroguanine formation as an indicator of inflammation-related DNA lesions. The staining intensity of 8-nitroguanine was significantly higher in cancer cells and inflammatory cells in the stroma of NPC tissues than in chronic nasopharyngitis tissues. Expression levels of CD44v6 and ALDH1A1 were significantly increased in cancer cells of primary NPC specimens in comparison to chronic nasopharyngitis tissues. Similarly, more intense staining of CD44v6 and ALDH1A1 was detected in an NPC cell line than in an immortalized nasopharyngeal epithelial cell line. In the case of CD24 staining, there was no significant difference between NPC and chronic nasopharyngitis tissues. 8-Nitroguanine was detected in both CD44v6- and ALDH1A1-positive stem cells in NPC tissues. In conclusion, CD44v6 and ALDH1A1 are candidate stem cell markers for NPC, and the increased formation of DNA lesions by inflammation may result in the mutation of stem cells, leading to tumor development in NPC.
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22

Bezrukova, E. V., E. V. Vorobeychikov, V. G. Konusova, A. V. Sosunov, M. M. Shamtsyan, S. A. Artyushkin, and A. S. Simbirtsev. "Effect of immune drugs to treat acute viral nasopharyngitis." Medical Immunology (Russia) 23, no. 5 (November 17, 2021): 1151–64. http://dx.doi.org/10.15789/1563-0625-eoi-2300.

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The task in treating acute nasopharyngitis (ANP) deals with reducing the disease symptoms and the risk of complications. The lack of reliable antiviral drugs makes it important to search for appropriate medicines among other pharmacotherapeutic groups.The study involves a comparative analysis of the efficiency and estimates potential: the recombinant interferon α2b and the compound containing fungal β-D-glucans used in treat ANPThe studies involved patients with ANP from 18 to 55 years old. As many as 152 people were examined including the following: 38 were practically healthy people (group 1); and 114 patients wuth ANP: 38 people (group 2) was subject to a standard therapy (vasoconstrictor nasal drops, nasal cavity irrigation using 0.1% Miramistine solution, gargling using the Furacilin solution); forty people (group 3) were administered application of intranasal interferon α2b of 105 IU, it was delivered with a spray into each nasal passage twice a day; 36 people (group 4) were administered an immunotropic drug containing β-D-glucans orally twice a day. The duration of drug administration lasted 7 days. Polymerase chain reaction (PCR) was used to identify the ANP etiological factor. Concentrations of cytokines IL-1β, IL-1ra were estimated using enzyme immunoassay (ELISA) technique. Clinical efficiency was assessed through score approach. The following symptoms were taken into account: general malaise, sore throat, character of nasal discharge, and the difficulty of nasal breathing. The results of the study were analyzed using parametric and nonparametric statistical methods. In 60.0% the nasal secretions of patients revealed RV. The distribution of cytokine concentrations in nasal secretions in group 1 indicated that the concentration of IL-1β was in the range of 20.0-25.0 pg/ml, and the concentration of IL-1ra was about 1250.0-2500.0 pg/ml. Developing ANP stimulated an increase in IL-1β concentration up to 30.0-70.0 pg/ml in nasal secretions of patients without affecting IL-1ra concentrations. On day 7 of treatment, the cytokine concentrations among the patients treated using the immunotropic drugs were the same as in the group of healthy individuals. There were no significant changes in cytokine production on day 7 in the group of patients undergoing the standard treatment. Application of proposed immunobiological medicines to ANP does not result in overproduction of proinflammatory cytokine IL-1β in nasal secretion. This confirms that these drugs are promising in the treating strategy including reduction of the risk of developing complications.
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23

Fenton, John E., and Stephen M. Kieran. "Re: Nasopharyngitis is a Clinical Sign of Laryngopharyngeal Reflux." American Journal of Rhinology 21, no. 1 (January 2007): 135. http://dx.doi.org/10.1177/194589240702100101.

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24

Brook, I. "Aerobic and anaerobic bacteriology of purulent nasopharyngitis in children." Journal of Clinical Microbiology 26, no. 3 (1988): 592–94. http://dx.doi.org/10.1128/jcm.26.3.592-594.1988.

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25

Akhtyamov, D. R., E. V. Shabaldina, S. V. Grivtsova, S. V. Apal’ko, and A. V. Shabaldin. "Immunomodulatory effect of adenoidectomy in infants and preschool children with high degrees of adenoid hypertrophy and recurrent nasopharyngitis." Russian Otorhinolaryngology 21, no. 1 (2022): 27–41. http://dx.doi.org/10.18692/1810-4800-2022-1-27-41.

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It is known that 50% of children with constantly recurrent acute nasopharyngitis have high degrees of hypertrophy of the pharyngeal tonsil (2nd and 3rd degree). Adenoidectomy can remove obstruction of the nose and Eustachian tube. At the same time, it is assumed that the removal of the pharyngeal tonsil will also limit inflammation on the mucous membrane of the nose and pharynx. This effect may be positive both in terms of reducing the frequency of respiratory diseases and in preventing the early manifestation of chronic respiratory diseases. Materials and methods. 101 children were examined, in the age range of 2–6 years, who were in the children’s department of Otolaryngology of the Regional Children’s Clinical Hospital in Kemerovo for adenoidectomy. An objective examination of the ENT organs in the main group was carried out; biological material from the pharyngeal tonsil for PCR tests and DNA markers of viruses, bacteria, and fungi in the pharyngeal bioburden was collected; nasopharyngeal lavages for cytokine testing were collected. Results: Adenoidectomy significantly reduces the incidence of nasopharyngitis in children with high degrees of pharyngeal tonsil hypertrophy. The effect of adenoidectomy is associated with an immunomodulatory effect on the mucosal immunity of the nose and pharynx. After adenoidectomy, the level of topical cytokines that increase inflammation (IL-1b, IL-1Ra) decreases. Adenoidectomy effectively reduces the incidence of nasopharyngitis in infants and preschool children with elevated levels of IL-4 in the nasopharyngeal lavage. Adenoidectomy has a significant biodebridement effect for the nasopharyngeal bioburden through a decrease in the expression of DNA markers of bacteria (pyogenic streptococcus), viruses (Epstein–Barr virus), and fungi (Candida genus). The effect of adenoidectomy in relation to limiting the frequency of nasopharyngitis in children of early and preschool age is reduced with concomitant bronchial asthma and seasonal allergic rhinosinusitis; high concentration in the nasopharyngeal washout of TNF-α, a significant representation of the coccal bioburden according to rhinocytogram data, and increased expression of DNA markers of the Epstein–Barr virus in the cells of the nasopharyngeal mucosa.
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Ivanova, O. N., and A. S. Golderova. "The study of immunity features in children with chronic nasopharyngitis." Yakut Medical Journal, no. 1 (2018): 43–44. http://dx.doi.org/10.25789/ymj.2018.61.13.

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Gaffney, Máire, Ross O’Shea, Majura Kaare, and John Eugene Fenton. "AB118. SOH21AS063. Nasopharyngitis as a clinical indicator of laryngopharyngeal reflux." Mesentery and Peritoneum 5 (April 2021): AB118. http://dx.doi.org/10.21037/map-21-ab118.

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葛, 瑞锋. "One Case Analysis of Treatment of Chronic Nasopharyngitis with Clarithromycin." Advances in Clinical Medicine 08, no. 01 (2018): 79–84. http://dx.doi.org/10.12677/acm.2018.81015.

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Lyu, Jie-Yu, Jian-Yong Chen, Xiao-Jun Zhang, Meng-Wen Zhang, Geng-Sheng Yu, Liang Zhang, and Zhong Wen. "Septin 9 Methylation in Nasopharyngeal Swabs: A Potential Minimally Invasive Biomarker for the Early Detection of Nasopharyngeal Carcinoma." Disease Markers 2020 (May 5, 2020): 1–7. http://dx.doi.org/10.1155/2020/7253531.

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Nasopharyngeal carcinoma (NPC) is highly prevalent in Southeast Asia, and an unfavorable outcome is usually attributed to advanced stage NPC. Current methods for the early diagnosis of NPC have limitations in clinical practice. The aim of this study was to investigate the diagnostic ability of Septin 9 methylation for NPC. A quantitative methylation-sensitive PCR (qMS-PCR) assay was developed to measure the methylation status and levels of Septin 9 in nasopharyngeal tissues and paired swabs from patients with NPC, chronic nasopharyngitis, and healthy donors. Methylated Septin 9 was detected in 92% (23/25) of NPC tissues and 25% (4/16) of nasopharyngitis controls (p<0.05). High-frequency hypermethylation with decreased mRNA expression of Septin 9 in NPC was also identified. Further, Septin 9 methylation was identified in 90.5% (19/21) of NPC biopsies and 71.4% (15/21) of paired swabs, indicating a good concordance between the two sample types. In addition, methylated Septin 9 was found in 16 (72.7%) nasal swabs from 22 NPC patients, 2 of 19 (10.5%) nasopharyngitis, but not in any of the healthy controls (p<0.01). The methylation score in nasal swabs of the NPC group was also significantly higher than that of non-NPC controls (p<0.001). Moreover, receiver operating characteristic (ROC) curve analysis showed an area under the curve (AUC) of 0.882 of Septin 9 methylation tests to discriminate NPC from non-NPC subjects. Our study demonstrated that frequent methylation of Septin 9 was present in NPC. Its detection in nasopharyngeal swabs may provide a minimally invasive and informative method for identifying early NPC cases.
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Popovych, Vasyl І., Oleksii І. Leta, and Ivanna V. Koshel. "The Rehabilitation of the Nasopharyngeal Microbiome in Patients with Chronic Nasopharyngitis." Acta Balneologica 64, no. 4 (2022): 337–41. http://dx.doi.org/10.36740/abal202204111.

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Aim: To evaluate the effect of immunorehabilitation therapy of CNP associated with Epstein-Barr virus on the nasopharyngeal microbiome changes and related to them indications for surgery. Materials and Methods: 20 healthy individuals and 32 patients diagnosed with CNP associated with Epstein-Barr virus were included in the study. The qualitative composition of microbiome and its quantitative characteristics were studied during the course of immunorehabilitation therapy with the phytoextract BNO 1030. The findings were compared with the features of the course of disease and existence of indications for surgical treatment. Results: In patients with indications for adenotomy, a nasopharyngeal dysbiosis was formed through elimination of commensal bacteria and contamination of nasopharynx with opportunistic and pathogenic bacteria, Candida fungi. The immunorehabilitation therapy helped 75% patients gain a pronounced clinical response and refuse operative treatment. The qualitative and quantitative composition of commensal flora, reduction in the rate of opportunistic flora and elimination of pathogenic and fungal flora were observed in such patients. In 25% patients with poor therapeutic efficacy and indications for adenotomy against the background of elimination of pathogenic and fungal flora, the level of commensal and opportunistic flora of nasopharynx remained unchanged. Conclusions: The immunorehabilitation helps 75% patients normalize the microbiome of nasopharynx, improve the clinical symptomatology and cancel the indications for surgical treatment.
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Tkachоva, O. V., and A. O. Silaev. "Clinical and economic analysis of pharmacotherapy of children with acute nasopharyngitis." Socìalʹna farmacìâ v ohoronì zdorov'â 2, no. 3 (September 2, 2016): 75–82. http://dx.doi.org/10.24959/sphhcj.16.54.

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Koshel, I. V., O. I. Leta, and M. M. Bahrii. "MORPHOLOGICAL JUSTIFICATION OF IMMUNOREHABILITATION THERAPY OF CHRONIC NASOPHARYNGITIS ASSOCIATED WITH EBV." Art of Medicine 23, no. 3 (October 18, 2022): 58–63. http://dx.doi.org/10.21802/artm.2022.3.23.58.

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Adenotomy, the most widespread surgery in children, which does not solve the problem of symptoms in 19-26% patients. The main reasons are related diseases of nasopharynx, therefore, the indications for surgical intervention must be considered after evaluating the efficacy of conservative treatment. The relevant conservative treatment of CNP associated with EBV infection must include adequate immunorehabilitation effect on nasopharynx epitheliocytes, since the interaction of local immune response and cells infected with Epstein-Barr virus can lead to the control of virus infection. Objective of research: to establish the specific features of morphological changes in respiratory epithelium of pharyngeal tonsil in patients with chronic nasopharyngitis associated with EBV. Materials and methods. There was carried out the research of surgical material obtained as a result of endoscopic surgical intervention including the removal of hypertrophic part of pharyngeal tonsil in 15 patients diagnosed with chronic nasopharyngitis associated with EBV. The diagnosis was made on the ground of a typical clinical picture and determination of immunoglobulin M, G classes to Epstein-Barr virus in the blood. Results. It has been shown that intraepithelial lymphocytic and histiocytic infiltration can be determined morphologically and the edema of loose connective tissue, full blood vessels of the microcirculatory channel can be determined subepithelially which is the morphological sign of the chronic inflammation process. The identified structural reconstruction of epithelium reflects the development of virus-induced degenerative processes, namely, koilocytosis and spongiosis. The virus-induced changes in epithelium in the form of koilocytosis can be observed both in covering epithelia and in metaplastic epithelium, which demonstrates the persistence of viral infection in chronic inflammation. It has been found that on the background of chronic inflammation the cystic formations in the thickness of the lymphoid tissue are forming and the amphophilic masses of mucus can be visualized on the surface of epitheliocytes with hypersecretory changes, as well as similar mucous masses can be identified in the lumen of cysts of lymphoid tissue. The changes in epithelium in the form of koilocytosis can be seen in the epithelial crypts and cysts as well as indicating that the persistence of infection is viral. Conclusions: In CNP associated with EBV, the morphological changes of respiratory epithelium of nasopharynx are indications of both non-specific inflammatory processes (hyperplasia, metaplasia of epithelium, hypersecretory changes in cells, intraepithelial inflammatory cell infiltration), and specific for viral infections processes (koilocytosis, spongiosis, lymphocytes with wide cytoplasm). Structural changes are indications of the development of degenerative virus-induced processes (koilocytosis, spongiosis) combined with reactive changes in epithelial cells (hyperplasia, hypersecretion) that happen both in the surface epithelium and in the crypts with cyst formations. There can be seen phenomena of significant hypersecretory activities of epithelium including the accumulation of mucus on the surface of cells as well as in the lumen of crypts and cysts.
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33

Lau, S. K., S. Kwan, J. Lee, and W. I. Wei. "Source of tubercle bacilli in cervical lymph nodes: A prospective study." Journal of Laryngology & Otology 105, no. 7 (July 1991): 558–61. http://dx.doi.org/10.1017/s0022215100116603.

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AbstractA prospective study searching for associated mycobacterial infection of the upper aerodigestive tract in patients with cervical tuberculous lymphadenitis (TBLN) was carried out. One hundred and thirteen patients with a clinical suspicion of cervical TBLN were included. All patients had a physical examination of the upper aerodigestive tract. Routine endoscopy and biopsy of the nasopharynx were performed. All of them had surgery to the cervical lymph node. Seventy-five patients had histologically confirmed cervical TBLN. Culture of the lymph node specimen showed Mycobacterium tuberculosis in 68 (90 per cent). In 45 (60 per cent) patients with cervical TBLN the primary foci of infection could not be found. Twenty-nine (39 per cent) had radiographic evidence of active or healed pulmonary tuberculosis. Sputum culture from two patients showed Mycobacterium tuberculosis. Five patients (six per cent) had tuberculous nasopharyngitis. In one of them (one per cent) the tuberculous nasopharyngitis was primary as no other evidence of mycobacterial infection was found. In the present study, mycobacterial infection of other parts of the upper aerodigestive tract was not found.
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Zhang, Liqian, Zunni Zhang, Liuqun Qin, Xiang Shi, Qisheng Su, and Wuning Mo. "SDF2L1 Inhibits Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma." BioMed Research International 2020 (August 7, 2020): 1–12. http://dx.doi.org/10.1155/2020/1970936.

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The purpose of this study was to explore the relationship between stromal cell-derived factor 2-like 1 (SDF2L1) and nasopharyngeal carcinoma (NPC). 12 NPC tissues and 12 chronic nasopharyngitis tissues were involved in our study. Quantitative real-time PCR (qRT-PCR) and Western Blot were utilized to detect the expression of SDF2L1. Besides, immunofluorescence analysis was utilized to determine the protein expression of 97 paraffin-embedded NPC tissues and 58 nasopharyngitis tissues. Biological functional experiment included Cell Counting Kit-8 (CCK-8) assay, cell clone formation assay, cell scratch migration assay, Transwell migration assay, and Transwell invasion assay. All data were analyzed by SPSS. Results showed that downexpression of SDF2L1 was prominently present in NPC tissues and cells. Furthermore, silencing the expression of SDF2L1 promoted NPC proliferation, migration, and invasion in vitro, while overexpression of SDF2L1 has the opposite effect. In conclusion, SDF2L1 may act as a cancer suppressor gene, play a crucial role in the occurrence and development of NPC, and be a new therapeutic target or prognostic indicator for NPC.
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Savlevich, Savlevich E. L., Simbirtsev A. S. Simbirtsev, Chistyakova G. N. Chistyakova, Terekhina K. G. Terekhina, and Batskalevich N. A. Batskalevich. "The state of systemic and local immunity in acute nasopharyngitis with ARVI." Therapy 4_2021 (May 3, 2021): 57–63. http://dx.doi.org/10.18565/therapy.2021.4.57-63.

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36

Wang, Shumin, Ning Ma, Shosuke Kawanishi, Yusuke Hiraku, Shinji Oikawa, Ying Xie, Zhe Zhang, Guangwu Huang, and Mariko Murata. "Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/507353.

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Nasopharyngeal carcinoma (NPC) is one of the most prevalent malignant tumors with poor prognosis in Southern China and Southeast Asia. Angiogenesis-related molecules can be promising therapeutic targets in NPC. To investigate the relationships of cancer-associated fibroblasts (CAFs) and chemokine-related molecules with neoangiogenesis, we compared immunohistochemical analyses of alpha-smooth-muscle actin (α-SMA), stroma-derived factor-1 (SDF-1), and its receptor CXCR4 in primary NPC specimens and chronic nasopharyngitis tissues. In addition, we examined the expression of vascular endothelial growth factor (VEGF-A), and CD133- and VEGF- receptor-2 (VEGFR-2) double positive cells, as endothelial progenitor cells (EPCs). We also assessed CD34-positive microvessels. Significantly higher expression ofα-SMA was observed in fibroblasts in NPC stroma. The immunoreactive intensities of SDF-1 and CXCR4 were significantly higher in NPC cells. CXCR4-positive cells and CD133/VEGFR-2- double positive cells were observed in the stroma surrounding cancer nests, and VEGF was detected in both cancer and stromal cells. Microvessel density was significantly higher in the stroma of NPC tissues compared to chronic nasopharyngitis tissues. Our data suggest that CAFs and NPC tumor cells may enhance neoangiogenesis in a VEGF- and SDF-1-dependent manner by recruiting EPCs from the bone marrow into tumor stroma.
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Guan, Renzheng, Yanli Liu, Dunqiang Ren, Jinfeng Li, Tao Xu, and Haiyan Hu. "The efficacy and safety of fluticasone propionate/formoterol compared with fluticasone propionate/salmeterol in treating pediatric asthma: a systematic review and meta-analysis." Journal of International Medical Research 48, no. 3 (December 18, 2019): 030006051988944. http://dx.doi.org/10.1177/0300060519889442.

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Objective To evaluate the efficacy and safety of fluticasone propionate/formoterol (FP/FORM) versus fluticasone propionate/salmeterol (FP/SAL) in treating pediatric asthma during a 12-week treatment cycle. Methods Randomized controlled trials of FP/FORM compared with FP/SAL in treating pediatric asthma were searched systematically using Medline, Embase, and the Cochrane Controlled Trials Register. Results Two articles including 546 patients were evaluated. The FP/SAL group showed obvious improvements in pre-dose forced expiratory volume in 1 s (FEV1) from day 0 to 84, asthma symptom scores, and sleep disturbance scores compared with the FP/FORM group; however, the FP/FORM group had improved peak expiratory flow rate (PEFR). In terms of 2-hour post-dose FEV1 from day 0 to 84, 2-hour forced expiratory flow at 25%, 50%, and 75%, and 2-hour forced vital capacity, we observed no significant differences between the two groups. For safety, including patients with at least one adverse event, bronchitis, cough, or pharyngitis, both groups had similar incidences, differing only in incidence of nasopharyngitis. Conclusion Compared with FP/FORM, FP/SAL showed a clear improvement in pre-dose FEV1, asthma symptom scores, and sleep disturbance scores. However, FP/FORM resulted in improved PEFR with a lower incidence of nasopharyngitis.
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Karthikeyan, P., Nikhil Sivanand, Neelima Vijayan, Vishnu Kumar, Nanditha Srinivasa, and Vignesh Raghavan. "Fungal nasopharyngitis masquerading as nasopharyngeal mass in an immunocompetent patient: a case report." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 5 (August 27, 2019): 1407. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20193893.

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<p><span>Isolated nasopharyngeal candidiasis in an immunocompetent host, has not been reported in literature. This is a case of a 48 year old lady with no comorbidities who presented with a mass in the nasopharynx mimicking nasopharyngeal malignancy. Endoscopic debridement and biopsy revealed necrotic tissue with fungal ball composed of filamentous hyphae suggestive of aspergillus and budding yeast form of Candida. A diagnosis of fungal nasopharyngitis was made and started on antifungal therapy for 6 weeks following which patient is relieved of symptoms.</span></p>
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39

Попович, В. И., and Г. В. Бекетова. "Mythical Diagnoses in Pediatrics: Adenoiditis or Nasopharyngitis? Which diagnosis is correct? Questions and Answers." Педиатрия. Восточная Европа, no. 2 (June 17, 2021): 294–303. http://dx.doi.org/10.34883/pi.2021.9.2.013.

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В педиатрии существует много так называемых мифических диагнозов, среди которых и «аденоидит», который часто используется врачами первого контакта. В статье в форме вопросов и ответов представлена мультидисциплинарная дискуссия, касающаяся анатомо-физиологических подходов в формировании диагноза «острый риносинусит» и «острый назофарингит». Авторы обсуждают врачебные ошибки в отношении синдрома насморка у детей, неправомерности диагноза «аденоидит», понятия «аденоидные вегетации», физиологической роли лимфоидной ткани в носоглотке. Представлены клинические критерии острого риносинусита и острого назофарингита, их этиология и патогенетическая сущность. Рассмотрены современные подходы к лечению поражений носа, околоназальных пазух и носоглотки с использованием стандартизованных фитониринговых препаратов Синупрет и Имупрет. In pediatrics, there are many so-called mythical diagnoses, including “adenoiditis”, which is often used by doctors of the first contact. The article in the form of “questions and answers” presents a multidisciplinary discussion concerning the anatomical and physiological approaches in the formation of the diagnoses “acute rhinosinusitis” and “acute nasopharyngitis.” The authors discuss medical errors in relation to the rhinitis syndrome in children, inappropriateness of the diagnosis of “adenoiditis”, the concept of “adenoid vegetation”, physiological role of lymphoid tissue in the nasopharynx. The clinical criteria for acute rhinosinusitis and acute nasopharyngitis, their etiology and pathogenetic essence are presented. Modern approaches to the treatment of lesions of the nose, paranasal sinuses, and nasopharynx using the standardized phytoneering drugs Sinupret and Imupret are considered.
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Kusuyama, Toshiyuki, Shunya Ikeda, Hideki Nakagawa, Ayumi Sawada, and Shinta Kimura. "A Clinical Study of Cases of Singers with Voice Disorder Caused by Nasopharyngitis." Japan Journal of Logopedics and Phoniatrics 58, no. 4 (2017): 333–38. http://dx.doi.org/10.5112/jjlp.58.333.

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41

Solodovnikova, O. N., A. Yu Diagileva, and A. A. Ploskireva. "Inosine pranobex in the treatment of children with acute respiratory viral infections. Non-interventional observation program ‘Ambulatory’." Voprosy praktičeskoj pediatrii 16, no. 6 (2021): 167–72. http://dx.doi.org/10.20953/1817-7646-2021-6-167-172.

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Respiratory infections are currently very common among children of different ages. Acute upper respiratory tract infections usually accounted for more than 88% of all infectious and parasitic diseases, which is consistent with data for the last 10 years. Therefore, the issues related to both causal and pathogenetic therapy for viral infections in children remain highly relevant. Key words: acute respiratory viral infections, children, infectious diseases, acute nasopharyngitis, acute pharyngitis, acute laryngitis, acute tracheitis, acute laryngopharyngitis, acute upper respiratory tract infection not otherwise specified
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42

Molochek, Yuri, and Oleksii Fediuk. "Evaluation of the clinical efficiency of topical antibacterial therapy of chronic nasopharyngitis after adenotomy." OTORHINOLARYNGOLOGY No5(5) 2022, No5(5) 2022 (October 31, 2022): 81–85. http://dx.doi.org/10.37219/2528-8253-2022-5-81.

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The presented article provides research, analysis and discussion regarding the rationality and clinical effectiveness of topical antibacterial therapy for chronic nasopharyngitis after adenotomy, in particular the effectiveness of the drug Izofra. Thanks to the study, the effectiveness of the drug Izofra in the postoperative period was substantiated and analysed. The authors obtained valuable information, knowledge and experience thanks to a randomized sample study with the main and control groups, namely, confirmation of the pronounced anti-inflammatory, antibacterial effect of the drug Izofra and its objective rationality of use. Significant reduction of inflammation, reduction of edema, improvement of secretion rheology and increase of local immunity after use of the drug Izofra have been studied and analysed. The topical antibacterial, anti-inflammatory, anti-edematous effect and eradication of planktonic forms of microorganisms (biofilms) of the drug Izofra clinically demonstrated a decrease in the level of postoperative complications, chronicity of the process, relapses and improvement of the postoperative course of treatment of children.
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Kharseeva, Galina G., E. O. Mangutov, O. M. But, A. V. Chepusova, and E. L. Alutina. "ANALYSIS OF THE FREQUENCY OF ISOLATION OF CORYNEBACTERIA NON-DIPHTHERIA FROM PATIENTS WITH INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT." Russian Clinical Laboratory Diagnostics 64, no. 7 (October 7, 2019): 430–34. http://dx.doi.org/10.18821/0869-2084-2019-64-7-430-434.

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Corynebacteria non-diphtheria and, in particular, C. pseudodiphtheriticum species that are closely related to C. propinquum and C. striatum form a group of new respiratory pathogens leading to the development of bronchitis, tracheitis, exacerbation of chronic obstructive pulmonary diseases, nosocomial pneumonia and other pathology. The goal is to analyze the frequency of the release of Сorynebacteria non-diphtheria from the upper respiratory tract of patients with various inflammatory diseases of the respiratory tract. Strains of Сorynebacteria non-diphtheria (C. pseudodiphtheriticum, C. propinquum, C. accolens, et al.), isolated from patients with inflammatory diseases of the respiratory tract (60 pcs.) and practically healthy individuals (31 pcs.) were studied. Identification of Сorynebacteria was performed using the method of mass spectrometry (MALDI-ToFMS). Сorynebacteria non-diphtheria in the amount of 105 and higher were more frequently detected with the development of chronic tonsillitis (60.0%) and nasopharyngitis (30%). The strains of C. pseudodiphtheriticum (40.0±6.4%) and the closely related species C. propinquum (21.7±5.3%) were mainly found; much less often - C. accolens (8.3±3.6%), C. afermentans (6.7±3.3%), et al. In 86.7% of cases, Corynebacteria non-diphtheria were isolated from children. In chronic tonsillitis, C. pseudodiphtheriticum and the closely related species of C. propinquum were isolated more often; in nasopharyngitis and bronchitis - С. pseudodiphtheriticum. Isolation of Corynebacteria non-diphtheria and, especially, C. pseudodiphtheriticum, C. propinquum, C. accolens species from patients with inflammatory diseases of the respiratory tract in the amount of 105 and above, if there are no other pathogenic microorganisms in the role of microbial associates, of clinical importance.
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Ooi, Zhi Yin, Nurul Abidah Mohd Ghazali, Nang Juniza Nik Zahari, Huan Keat Chan, Norsiah Md Noor, Noor Liani Harun, Mohd Firdaus Abu Bakar, and Mohd Redhuan Abdul Muin. "Patient profile and antibiotic use in a dedicated upper respiratory tract infection clinic based in a primary healthcare setting during COVID-19 pandemic in Malaysia: A cross sectional study." Malaysian Family Physician 17, no. 3 (August 25, 2022): 74–83. http://dx.doi.org/10.51866/oa.38.

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Introduction: Upper respiratory tract infection (URTI) is commonly encountered at the primary care level. Its management is particularly challenging due to the similarity of its symptoms to coronavirus disease 2019 (COVID-19) infection. Our study evaluated the profiles and antibiotic use of patients seeking care from a dedicated community-based URTI clinic during the COVID-19 pandemic. Methods: A cross-sectional study was conducted. Data were obtained from the medical records of patients visiting the URTI clinic at the Alor Setar Primary Healthcare Centre between March and April 2020. Results: Overall, 587/4388 (13.3%) patients received treatment at the URTI clinic. Most patients were male (60.6%) and aged between 20 and 39 years (35.5%). Their most common symptoms were cough (68.4%), fever (31.6%), runny nose (24.6%), and sore throat (24.1%). Most patients were diagnosed with acute nasopharyngitis (52.5%), acute pharyngitis (18.6%), or acute tonsillitis (5.3%). The symptomatic medication prescription rate was 96.5%. Only 26 of the 435 patients diagnosed with URTI received antibiotics, yielding an antibiotic use rate of only 6.0% for URTI relative to overall drug use. Acute tonsillitis was more common in children <12 years old (p<0.001), while a cough and runny nose were more commonly indicative of acute nasopharyngitis than other conditions (p<0.001). Sore throat was more likely to be a symptom of acute pharyngitis (p<0.001) and acute tonsillitis (p<0.001). Conclusion: Despite the challenges faced during the COVID-19 pandemic, the findings suggest that patients with URTI-like symptoms were properly managed, and the rate of antibiotic usage remained reasonable.
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Elies, Wolfgang, and Yannick Pletan. "An International Medico-Economic Survey of 2007 Children with Recurrent Nasopharyngitis and Acute Otitis Media." Drugs 54, Supplement 1 (1997): 5–12. http://dx.doi.org/10.2165/00003495-199700541-00004.

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46

DelGaudio, John M. "Response to Letter to the Editor Re: Nasopharyngitis is a Clinical Sign of Laryngopharyngeal Reflux." American Journal of Rhinology 21, no. 1 (January 2007): 135. http://dx.doi.org/10.1177/194589240702100102.

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47

Mikhailova, E. V., T. N. Malyugina, M. A. Matveeva, A. Yu Serdyukov, T. K. Chudakova, E. E. Raskina, P. A. Zheleznikov, and N. V. Malinina. "RETROSPECTIVE ANALYSIS OF THE UPPER AND LOWER RESPIRATORY TRACT DISEASES IN CHILDREN VACCINATED AGAINST PNEUMOCOCCAL INFECTION DURING THE NEW CORONAVIRUS INFECTION PANDEMIC." Pediatria. Journal named after G.N. Speransky 101, no. 5 (October 21, 2022): 63–69. http://dx.doi.org/10.24110/0031-403x-2022-101-5-63-69.

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According to the WHO data, the pneumococcal infection (PI) is recognized as one of the most dangerous of all vaccine-preventable diseases due to its high mortality rates. The purpose of the study was to analyze the incidence of acute diseases of the upper and lower respiratory tract in children depending on the presence and frequency of vaccinations against PI with PREVNAR 13® vaccine during the new coronavirus infection (COVID-19) pandemic. Materials and methods of the research: a retrospective analysis of the child development histories (Form No. 112/u “Child Development History”) of 92 children (45 boys, 47 girls) aged 3.1 [2.2; 3.5] years old observed in the Treatment-and-Prophylactic Department No. 1 with the Saratov City Children's Polyclinic No. 8 (Saratov, Russia) in May 2020 - Dec. 2021. A single-center retrospective cohort study was conducted. Inclusion criteria were the absence of chronic pathology, developmental anomalies, background conditions and congenital immunodeficiency conditions. The authors analyzed the volume of cases with acute diseases of the upper and lower respiratory tract considering the most typical and the most frequent ones in children, such as: nasopharyngitis, tonsillopharyngitis, adenoiditis, acute bronchitis, and community-acquired pneumonia. Results: it was found that in children vaccinated against PI the decrease in the incidence of diseases of the upper and lower respiratory tract was recorded compared to unvaccinated children, and the maximum effectiveness of vaccination is achieved with a full vaccination course (the two consecutive vaccinations followed by a single revaccination (V1, V2, and RV). Conclusions: 1) in children who received a full course of vaccination against PI, nasopharyngitis was statistically significantly less common (3.55 cases per 1 child per year) than in children who did not receive a full course of vaccination (6.64 cases per 1 child per year) (p<0.001); adenoiditis (no cases were registered vs. 0.86 cases per 1 child per year, p<0.001); tonsillopharyngitis (0.4 cases per 1 child per year vs. 1.89 cases per 1 child per year, p<0.001), no cases of community-acquired pneumonia were detected vs. 0.22 cases per 1 child per year in children who did not receive a full course of vaccination. 2) among children vaccinated twice with the PREVNAR 13® vaccine compared to the children not vaccinated against PI there was a statistically significantly lower number of cases of adenoiditis i.e., 0.74 vs. 0.86 cases per 1 child per year, p<0.001; tonsillopharyngitis (0.6 vs. 1.89 cases per child per year, p<0.001). 3) among children who received a single shot of vaccination against PI compared to unvaccinated children there was a statistically significantly lower number of cases of nasopharyngitis (5.28 vs. 6.64 cases per 1 child per year, p<0.001).
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Guenin, Sophie Hélène, Abigail Cline, and Alexandra Schulz. "33608 Connecting the dots: A potential mechanism for increased rates of nasopharyngitis in secukinumab-treated patients." Journal of the American Academy of Dermatology 87, no. 3 (September 2022): AB35. http://dx.doi.org/10.1016/j.jaad.2022.06.175.

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49

Vlasova, Elena M., N. K. Voznesenskiy, V. B. Alekseev, and A. A. Vorobeva. "CONDITIONS OF THE DEVELOPMENT AND PECULIARITIES OF THE COURSE OF RESPIRATORY DISEASES IN SMELTERS OF TITANIUM ALLOYS." Hygiene and sanitation 97, no. 1 (January 15, 2018): 65–69. http://dx.doi.org/10.18821/0016-9900-2018-97-1-65-69.

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The working conditions, occupational and non-occupational risk factors, prevalence rate and peculiarities of the course of respiratory diseases in smelters of titanium alloys were studied. Working conditions of smelters are estimated as harmful (class of working conditions: 3.3-3.4.) due to factors: heating microclimate, chemicals (chlorine and hydrochloride, sulfur dioxide, nitrogen oxide), industrial dust. A feature of the respirable dust fraction is the high content of titanium oxide particles of the PM10 dimension. There was made an analysis of the health status of workers exposed to industrial dust, depending on the length of service. Diseases of the upper respiratory tract in smelters of titanium alloys were shown to be prevalent, simple catarrhal nasopharyngitis prevails with the subsequent formation of atrophic rhinitis, its prevalence rate among smelters of titanium alloys increases with the experience. The peculiarity of the development of diseases of the upper respiratory tract in smelters of titanium alloys are: deterioration of nasal breathing in workers with experience of from 1 year to 5 years already, in patients with experience from 10 to 15 years the prevalence of catarrhal nasopharyngitis and atrophic rhinitis as its outcome in cases with experience from 15 to 20 years. The bronchial damage in the smelters of titanium alloys develops under the experience more than 5 years. The clinical forms are dominated by the phenomena of catarrhal bronchitis followed by obstruction of the bronchi progressing with the experience, with the formation of irreversible ventilation disorders. With the depletion of antioxidant protection, as a rule, with long duration of the exposure of up to 10 years, aseptic inflammation is formed, which is pronounced clinically as catarrhal endobronchitis. This is a partially reversible pathological process. The described features of the development and course of respiratory diseases in smelters of titanium alloys should be taken into account during periodic medical examinations in order to timely prevent them
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Zhang, Lingli, Yin Yang, Yanhong Li, Zhengmin (Min) Qian, Wanli Xiao, Xiaojie Wang, Craig A. Rolling, et al. "Short-term and long-term effects of PM2.5 on acute nasopharyngitis in 10 communities of Guangdong, China." Science of The Total Environment 688 (October 2019): 136–42. http://dx.doi.org/10.1016/j.scitotenv.2019.05.470.

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