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Journal articles on the topic 'Natt'

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Published: 4 June 2021

Last updated: 13 February 2022

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1

IRFAN, AHMAD, ABDULLAH G. AL-SEHEMI, and ABDULLAH M. ASIRI. "THEORETICAL INVESTIGATIONS OF THE CHARGE TRANSFER PROPERTIES IN OLIGOTHIOPHENE DERIVATIVES." Journal of Theoretical and Computational Chemistry 11, no. 03 (2012): 631–40. http://dx.doi.org/10.1142/s0219633612500411.

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The structures of 5,5′-bis(naphth-2-yl)- 2,2′-bithiophene (NaT2), 5,5″-bis(naphth-2-yl)-2,2′:5′,2′-terthiophene (NaT3), 5,5‴-bis(naphth-2-yl)-2,2′:5′,2″:5″,2‴-tetrathiophene (NaT4), 5,5″″-bis(naphth-2-yl)-2,2′:5′,2″:5″,2‴:5‴,2″″-quinquethiophene (NaT5) and 5,5′″″-bis(naphth-2-yl)-2,2′:5′,2″:5″,2‴:5‴,2″″:5″″,2′″″-sexithiophene (NaT6) have been optimized at PBE1PBE/6-31G* level of theory. By increasing the chain length (thiophene units) energy gap decreases. The hole reorganization energy also decreases from NaT2–NaT6 . We have observed that mobility of NaT5 and NaT6 can be enhanced by minimizin

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Hem, Erlend. "Ulvetimen – dag eller natt?" Tidsskrift for Den norske legeforening 129, no. 18 (2009): 1908. http://dx.doi.org/10.4045/tidsskr.09.0999.

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3

Morris, Walter D., and Halvard Foynes. "Natt i New York." World Literature Today 63, no. 2 (1989): 318. http://dx.doi.org/10.2307/40144922.

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4

Solstad, Dag. "Om Professor Andersens natt." Samtiden, no. 02 (September 17, 2013): 4–17. http://dx.doi.org/10.18261/issn1890-0690-2013-02-03.

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Polevoda, Bogdan, Jason Hoskins та Fred Sherman. "Properties of Nat4, an Nα-Acetyltransferase of Saccharomyces cerevisiae That Modifies N Termini of Histones H2A and H4". Molecular and Cellular Biology 29, № 11 (2009): 2913–24. http://dx.doi.org/10.1128/mcb.00147-08.

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ABSTRACT Nat4, also designated NatD, was previously shown to acetylate the N termini of histones H2A and H4, which have SGGKG and SGRGK N termini (O. K. Song, X. Wang, J. H. Waterborg, and R. Sternglanz, J. Biol. Chem. 278:38109-38112, 2003). The analysis of chimeric proteins with various N-terminal segments of histone H4 fused to iso-1-cytochrome c revealed that efficient acetylation by NatD required at least 30 to 50 amino acid residues of the N terminus of histone H4. This requirement for an extended N terminus is in marked contrast with the major N-terminal acetyl transferases (NATs), i.e.

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6

Borges, Jorge Luis. "Bulletin om ei heil natt." Agora 28, no. 04 (2010): 140–41. http://dx.doi.org/10.18261/issn1500-1571-2010-04-09.

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Opsahl, Carl Petter. "Noen må synge i verdens natt." Kirke og Kultur 124, no. 01 (2020): 22–34. http://dx.doi.org/10.18261/issn.1504-3002-2020-01-03.

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8

Schoolfield, George C., and Tua Forsström. "Efter att ha tillbringat en natt bland hästar." World Literature Today 72, no. 3 (1998): 642. http://dx.doi.org/10.2307/40154157.

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9

STOKKELAND, JON MORGAN. "Jeg hadde slik en underlig drøm i natt…" Nordisk Psykologi 57, no. 4 (2005): 345–64. http://dx.doi.org/10.1080/00291463.2005.10637379.

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10

Tavares-Dias, Marcos, Antônio Aderson Oliveira-Júnior, and Jaydione Luiz Marcon. "Methodological limitations of counting total leukocytes and thrombocytes in reptiles (Amazon turtle, Podocnemis expansa): an analysis and discussion." Acta Amazonica 38, no. 2 (2008): 351–56. http://dx.doi.org/10.1590/s0044-59672008000200020.

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The aim of this paper is to compare three different methods for counting white blood cells [WBC] (Natt and Herrick method, estimation with 1,000 and 2,000 erythrocytes) and three methods for counting total thrombocytes [TT] (Wojtaszek method, estimation with 1,000 and 2,000 erythrocytes) in a South American freshwater turtle species, Podocnemis expansa, Schweigger 1812 (Reptilia, Pelomedusidae). Direct WBC counts using the Natt and Herrick method showed limitations, which are discussed here. The WBC and TT counts using 1,000 erythrocytes from blood smears are not recommended for Amazon turtles

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Taha, Mohammed Qasim, Zaid Hussien Ali, and Abdullah Khalid Ahmed. "Two-level scheduling scheme for integrated 4G-WLAN network." International Journal of Electrical and Computer Engineering (IJECE) 10, no. 3 (2020): 2633. http://dx.doi.org/10.11591/ijece.v10i3.pp2633-2643.

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In this paper, a novel scheduling scheme for the Fourth Generation (4G)-Wireless Local Area Network (WLAN) network is proposed to ensure that end to end traffic transaction is provisioned seamlessly. The scheduling scheme is divided into two stages; in stage one, traffic is separated into Actual Time Traffic (ATT) and Non-Actual-Time Traffic (NATT), while in stage two, complex queuing strategy is performed. In stage one, Class-Based Queuing (CBQ) and Deficit Round Robin (DRR) are used for NATT and ATT applications, respectively to separate and forward traffic themselves according to source req

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12

Ma, Xuanlong, Alfredo Huete, Caitlin E. Moore, et al. "Spatiotemporal partitioning of savanna plant functional type productivity along NATT." Remote Sensing of Environment 246 (September 2020): 111855. http://dx.doi.org/10.1016/j.rse.2020.111855.

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Madsen, Tonya S. "En natt uten måne og stjerner - Om dødsdrift og livsvilje." Agora 31, no. 01-02 (2014): 225–51. http://dx.doi.org/10.18261/issn1500-1571-2014-01-02-16.

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Starheim, Kristian K., Darina Gromyko, Rune Evjenth та ін. "Knockdown of Human Nα-Terminal Acetyltransferase Complex C Leads to p53-Dependent Apoptosis and Aberrant Human Arl8b Localization". Molecular and Cellular Biology 29, № 13 (2009): 3569–81. http://dx.doi.org/10.1128/mcb.01909-08.

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ABSTRACT Protein Nα-terminal acetylation is one of the most common protein modifications in eukaryotic cells. In yeast, three major complexes, NatA, NatB, and NatC, catalyze nearly all N-terminal acetylation, acetylating specific subsets of protein N termini. In human cells, only the NatA and NatB complexes have been described. We here identify and characterize the human NatC (hNatC) complex, containing the catalytic subunit hMak3 and the auxiliary subunits hMak10 and hMak31. This complex associates with ribosomes, and hMak3 acetylates Met-Leu protein N termini in vitro, suggesting a model in

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Pezza, John A., Sara X. Langseth, Rochele Raupp Yamamoto, et al. "The NatA Acetyltransferase Couples Sup35 Prion Complexes to the [PSI+] Phenotype." Molecular Biology of the Cell 20, no. 3 (2009): 1068–80. http://dx.doi.org/10.1091/mbc.e08-04-0436.

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Protein-only (prion) epigenetic elements confer unique phenotypes by adopting alternate conformations that specify new traits. Given the conformational flexibility of prion proteins, protein-only inheritance requires efficient self-replication of the underlying conformation. To explore the cellular regulation of conformational self-replication and its phenotypic effects, we analyzed genetic interactions between [PSI+], a prion form of the S. cerevisiae Sup35 protein (Sup35[PSI+]), and the three Nα-acetyltransferases, NatA, NatB, and NatC, which collectively modify ∼50% of yeast proteins. Altho

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Næss, Hege Eileen, and Stian Biong. "Sykepleiepersonells beskrivelser av helsefremmende miljøterapi kveld, natt og helg i psykisk helsevern." Tidsskrift for psykisk helsearbeid 11, no. 01 (2014): 25–33. http://dx.doi.org/10.18261/issn1504-3010-2014-01-04.

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17

Ochaya, Stephen, Oscar Franzén, Doreen Asiimwe Buhwa, et al. "Characterization of Evolutionarily Conserved Trypanosoma cruzi NatC and NatA-N-Terminal Acetyltransferase Complexes." Journal of Parasitology Research 2019 (March 6, 2019): 1–11. http://dx.doi.org/10.1155/2019/6594212.

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Protein N-terminal acetylation is a co- and posttranslational modification, conserved among eukaryotes. It determines the functional fate of many proteins including their stability, complex formation, and subcellular localization. N-terminal acetyltransferases (NATs) transfer an acetyl group to the N-termini of proteins, and the major NATs in yeast and humans are NatA, NatB, and NatC. In this study, we characterized the Trypanosoma cruzi (T. cruzi) NatC and NatA protein complexes, each consisting of one catalytic subunit and predicted auxiliary subunits. The proteins were found to be expressed

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18

Carlos Erazo, Nancy, and Carol Alvarado Calderón. "Valores hematológicos de la taricaya (Podocnemis unifilis) en dos épocas del año en un parque zoológico de Iquitos, Perú." Revista de Investigaciones Veterinarias del Perú 31, no. 2 (2020): e16239. http://dx.doi.org/10.15381/rivep.v31i2.16239.

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El objetivo del estudio fue determinar los valores hematológicos de la taricaya (Podocnemis unifilis) en dos estaciones del año en un parque zoológico de Iquitos, Perú. El zoológico presenta una población de 80 taricayas. En el estudio se trabajó con 30 tortugas (18 machos, 12 hembras). Las muestras de sangre fueron tomadas en invierno (febrero) y verano (julio) y se analizaron utilizando la cámara de Neubauer y el dilutor Natt & Herrick. La estación del año influyó los valores hemáticos, aumentando el número de eritrocitos y azurófilos en verano, y de linfocitos y trombocitos en invierno.

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19

Rogers, Cassandra Denise Wilks, and Jason Beringer. "Describing rainfall in northern Australia using multiple climate indices." Biogeosciences 14, no. 3 (2017): 597–615. http://dx.doi.org/10.5194/bg-14-597-2017.

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Abstract. Savanna landscapes are globally extensive and highly sensitive to climate change, yet the physical processes and climate phenomena which affect them remain poorly understood and therefore poorly represented in climate models. Both human populations and natural ecosystems are highly susceptible to precipitation variation in these regions due to the effects on water and food availability and atmosphere–biosphere energy fluxes. Here we quantify the relationship between climate phenomena and historical rainfall variability in Australian savannas and, in particular, how these relationship

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20

Collins, Williams B., and Thomas S. Smith. "Twenty-four hour behaviour patterns and budgets of free-ranging reindeer in winter." Rangifer 9, no. 1 (1989): 2. http://dx.doi.org/10.7557/2.9.1.766.

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<p>Activities of free-ranging reindeer (Rangifer tarandus) on the Seward Peninsula, Alaska were studied to determine 24-hour behaviour patterns and budgets in winter. Use of daytime active-rest data to predict nighttime behaviour resulted in as much as 37% underestimate of nighttime resting and 37% overestimate of nighttime activity. Three active-rest cycles occurred daily, synchronous with photoperiod.</p><p>Tjuefiretimers adferdsm&oslash;nster- og budsjett hos fritt beitende reinsdyr om vinteren.</p><p>Abstract in Norwegian / Sammendrag: Aktiviteter hos frit

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Shakhmurzova, K. T., Zh I. Kurdanova, Arthur E. Baikaziev, Karina Kh Teunova, Azamat A. Zhansitov, and S. Yu Khashirova. "Methods for the Synthesis of Polyethereketone." Materials Science Forum 935 (October 2018): 27–30. http://dx.doi.org/10.4028/www.scientific.net/msf.935.27.

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The data on the methods for the preparation of polyetherketones by electrophilic and nucleophilic methods are considered and generalized. It is shown that polyetherketones by electrophilic substitution are carried out as homopolycondensation aromatic monocarboxylic acids and their halides and polycondensation of polynuclear aromatic hydrocarbons with aromatic dicarboxylic acids or their halides, and phosgene in organic solvents (1,2-dichloroethane, methylene chloride, nitrobenzene and etc.) in the presence of Ziegler-Natt catalysts. However, this process has not found an industrial application

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Hickman, D., J. Pope, S. D. Patil, et al. "Expression of arylamine N-acetyltransferase in human intestine." Gut 42, no. 3 (1998): 402–9. http://dx.doi.org/10.1136/gut.42.3.402.

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Background—ArylamineN-acetyltransferases in humans (NAT1 and NAT2) catalyse the acetylation of arylamines including food derived heterocyclic arylamine carcinogens. Other substrates include the sulphonamide 5-aminosalicylic acid (5-ASA), which is an NAT1 specific substrate; N-acetylation of 5-ASA is a major route of metabolism. NAT1 and NAT2 are both polymorphic.Aims—To investigate NAT expression in apparently healthy human intestines in order to understand the possible role of NAT in colorectal cancer and in the therapeutic response to 5-ASA.Methods—The intestines of four organ donors were di

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Haverd, V., B. Smith, M. Raupach, et al. "Coupling carbon allocation with leaf and root phenology predicts tree–grass partitioning along a savanna rainfall gradient." Biogeosciences 13, no. 3 (2016): 761–79. http://dx.doi.org/10.5194/bg-13-761-2016.

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Abstract. The relative complexity of the mechanisms underlying savanna ecosystem dynamics, in comparison to other biomes such as temperate and tropical forests, challenges the representation of such dynamics in ecosystem and Earth system models. A realistic representation of processes governing carbon allocation and phenology for the two defining elements of savanna vegetation (namely trees and grasses) may be a key to understanding variations in tree–grass partitioning in time and space across the savanna biome worldwide. Here we present a new approach for modelling coupled phenology and carb

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Haverd, V., B. Smith, M. Raupach, et al. "Coupling carbon allocation with leaf and root phenology predicts tree-grass partitioning along a savanna rainfall gradient." Biogeosciences Discussions 12, no. 19 (2015): 16313–57. http://dx.doi.org/10.5194/bgd-12-16313-2015.

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Abstract. The relative complexity of the mechanisms underlying savanna ecosystem dynamics, in comparison to other biomes such as temperate and tropical forests, challenges the representation of such dynamics in ecosystem and Earth system models. A realistic representation of processes governing carbon allocation and phenology for the two defining elements of savanna vegetation (namely trees and grasses) may be a key to understanding variations in tree/grass partitioning in time and space across the savanna biome worldwide. Here we present a new approach for modelling coupled phenology and carb

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Starheim, Kristian K., Thomas Arnesen, Darina Gromyko, Anita Ryningen, Jan Erik Varhaug та Johan R. Lillehaug. "Identification of the human Nα-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression". Biochemical Journal 415, № 2 (2008): 325–31. http://dx.doi.org/10.1042/bj20080658.

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Protein Nα-terminal acetylation is a conserved and widespread protein modification in eukaryotes. Several studies have linked it to normal cell function and cancer development, but nevertheless, little is known about its biological function. In yeast, protein Nα-terminal acetylation is performed by the N-acetyltransferase complexes NatA, NatB and NatC. In humans, only the NatA complex has been identified and characterized. In the present study we present the components of hNatB (human NatB complex). It consists of the Nat3p homologue hNAT3 (human N-acetyltransferase 3) and the Mdm20p homologue

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Gulati, P., and G. Thomas. "Nutrient sensing in the mTOR/S6K1 signalling pathway." Biochemical Society Transactions 35, no. 2 (2007): 236–38. http://dx.doi.org/10.1042/bst0350236.

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Nutrient overload induces constitutive S6K1 (S6 kinase 1) activation, which leads to insulin resistance by suppressing insulin-induced class I PI3K (phosphoinositide 3-kinase) signalling [Um, Frigerio, Watanabe, Picard, Joaquin, Sticker, Fumagalli, Allegrini, Kozma, Auwerx and Thomas (2004) Nature 431, 200–205]. This finding gave rise to the question of the mechanism by which nutrients, such as AAs (amino acids), enter the mTOR (mammalian target of rapamycin)/S6K1 signalling pathway. Counter to the prevailing view, our recent studies have shown that the AA input into the mTOR/S6K1 signalling p

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Karsono, Ramadhan, Denni Joko Purwanto, Samuel J. Haryono, et al. "Preoperative Neoadjuvant Hormonal Therapy and Neoadjuvant Chemotherapy for Stage 3B and 4 Breast Cancer Patients in Dharmais Hospital-National Cancer Center, Indonesia: A Cohort Study." Indonesian Journal of Cancer 12, no. 4 (2019): 109. http://dx.doi.org/10.33371/ijoc.v12i4.604.

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Background: There are no data of efficacy comparison between primary systemic therapy in stage 3B and 4 breast cancer patients in Indonesia. This study compared long term outcomes of breast cancer patients treated with neoadjuvant hormonal therapy (NAHT) and those treated with neoadjuvant chemotherapy (NACT)Methods: This was a cohort study conducted from 2011 to 2017. A total of 122 patients with stage 3B and 4 breast cancer received NAHT (n = 62) or NACT (n = 60) within a 6 cycles for NACT and 6 months for NAHT were included. Patients were excluded if they had a mastectomy before treatment, w

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Bjørkli, Hanne. "Overlevelse i grenseland. En lesning av Ingvar Ambjørnsens novelle "Skogens hjerte" fra novellesamlingen Natt til mørk morgen." Nordlit 6, no. 2 (2002): 21. http://dx.doi.org/10.7557/13.1969.

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DELOMÉNIE, Claudine, Geoffrey H. GOODFELLOW, Rajagopal KRISHNAMOORTHY, Denis M. GRANT, and Jean-Marie DUPRET. "Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis." Biochemical Journal 323, no. 1 (1997): 207–15. http://dx.doi.org/10.1042/bj3230207.

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The arylamine N-acetyltransferases (NATs) NAT1 and NAT2 are responsible for the biotransformation of many arylamine and hydroxylamine xenobiotics. It has been proposed that NATs may act through a cysteine-linked acetyl-enzyme intermediate in a general base catalysis involving a highly conserved arginine residue such as Arg64. To investigate this possibility, we used site-directed mutagenesis and expression of recombinant human NAT1 and NAT2 in Escherichia coli. Sequence comparison with NATs from other species indicated that Arg9 and Arg64 are the only invariant basic residues. Either mutation

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Howe, Cheryl A., Ryan A. Harris, and Bernard Gutin. "A 10-Month Physical Activity Intervention Improves Body Composition in Young Black Boys." Journal of Obesity 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/358581.

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Objective. To determine if a 10-month after-school physical activity (PA) intervention could prevent deleterious changes in body composition and cardiovascular (CV) fitness in young black boys.Methods. Following baseline measures, 106 boys (8–12 yrs) were randomized to either a control group or an intervention group, further divided into attenders (ATT) and nonattenders (NATT), participating in ≥60% or <60% of the intervention, respectively. The daily intervention consisted of skills development (25 min), vigorous PA (VPA, 35 min), and strengthening/stretching (20 min) components. Body comp

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Tomassi-Morawiec, Hanna, Jacek Wachowiak, and Grzegorz Czapowski. "GEOCHEMIA I WYKSZTAŁCENIE SKAŁ ZUBROWYCH GÓRNEGO PERMU (CECHSZTYN) Z OBSZARU POLSKI." Biuletyn Państwowego Instytutu Geologicznego 477 (2019): 69–122. http://dx.doi.org/10.7306/bpig.49.

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Praca prezentuje wyniki szczegółowych badań składu chemicznego skał zubrowych dwu głównych wydzieleń litostratygraficznych w cyklotemowej sukcesji osadów polskiego cechsztynu: zubra brunatnego (Na3t; cyklotem PZ3) i zubra czerwonego (Na4t; cyklotem PZ4) oraz innych cechsztyńskich ogniw i formacji zubrowych wyróżnionych na obszarze Polski. Skały te opróbowano w 2 wysadach solnych (Kłodawa i Mogilno) oraz w profilach 7 otworów wiertniczych. Utwory Na3t w wysadzie Kłodawa cechuje wyższy udział halitu w porównaniu ze skałami Na4t, które zawierają więcej materiału terygenicznego (materiał detrytycz

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Hansen, Ketil Fred. "Vetle Lid Larsen, 1001 natt: den utrolige historien om to norske slaver i Alger (Oslo: Cappelen Damm, 2013). 350 s." 1700-tal: Nordic Journal for Eighteenth-Century Studies 11 (August 17, 2014): 176–78. http://dx.doi.org/10.7557/4.3115.

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Millner, Lori M., Mark A. Doll, Jian Cai, J. Christopher States, and David W. Hein. "NATb/NAT1*4 promotes greater arylamine N -acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl." Molecular Carcinogenesis 51, no. 8 (2011): 636–46. http://dx.doi.org/10.1002/mc.20836.

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Valeriano-Pari, Vitaliano, Ludwing Á. Cárdenas-Villanueva, Martha M. Hancco-Gamarra, and Pedro Coila-Añasco. "Parámetros hematológicos del suri (Rhea pennata) en condiciones de cautiverio en el altiplano peruano." Revista de Investigaciones Veterinarias del Perú 30, no. 1 (2019): 143–48. http://dx.doi.org/10.15381/rivep.v30i1.15676.

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El estudio tuvo como objetivo evaluar las constantes hematológicas de la serie roja y blanca del suri (Rhea pennata) en cautiverio en el altiplano peruano, considerando, además, las variables sexo y edad. La toma de muestras se hizo en 28 individuos del Centro de Rescate Lupaca, provincia El Collao, región Puno, Perú, a 4530 msnm. Las aves fueron 14 hembras y 14 machos, correspondiente a siete juveniles (12-23 meses) y siete adultos (más de 24 meses) en cada caso. Los animales estaban aparentemente sanos y las muestras de sangre se obtuvieron en ayunas en horas de la mañana por punción en la v

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Kidd, La Creis Renee, Tiva T. VanCleave, Mark A. Doll, et al. "No Association between Variant N-acetyltransferase Genes, Cigarette Smoking and Prostate Cancer Susceptibility Among Men of African Descent." Biomarkers in Cancer 3 (January 2011): BIC.S6111. http://dx.doi.org/10.4137/bic.s6111.

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Objective We evaluated the individual and combination effects of NAT1, NAT2 and tobacco smoking in a case-control study of 219 incident prostate cancer (PCa) cases and 555 disease-free men. Methods Allelic discriminations for 15 NAT1 and NAT2 loci were detected in germ-line DNA samples using Taqman polymerase chain reaction (PCR) assays. Single gene, gene-gene and gene-smoking interactions were analyzed using logistic regression models and multi-factor dimensionality reduction (MDR) adjusted for age and subpopulation stratification. MDR involves a rigorous algorithm that has ample statistical

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Rodrigues-Lima, Fernando, Racquel N. Cooper, Bertrand Goudeau, et al. "Skeletal Muscles Express the Xenobiotic-metabolizing Enzyme Arylamine N-acetyltransferase." Journal of Histochemistry & Cytochemistry 51, no. 6 (2003): 789–96. http://dx.doi.org/10.1177/002215540305100610.

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The human arylamine N-acetyltransferases (NATs) NAT1 and NAT2 are enzymes responsible for the acetylation of many arylamines and hydrazines, thereby playing an important role in both detoxification and activation of many drugs and carcinogens. Both enzymes show polymorphisms but exhibit key differences in substrate selectivity and tissue expression. In the present study, reverse transcriptase-PCR, Western blotting, and immunohistochemistry were used to investigate the expression of the NATs in human skeletal muscle. Despite the presence of its mRNA, NAT2 enzyme level was below the limit of det

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Stanley, L. A., E. Coroneos, R. Cuff, D. Hickman, A. Ward, and E. Sim. "Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder." Journal of Histochemistry & Cytochemistry 44, no. 9 (1996): 1059–67. http://dx.doi.org/10.1177/44.9.8773572.

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The N-acetyltransferase (NAT) phenotype is an important determinant of individual susceptibility to occupational bladder cancer. N-Acetyltransferases arc known to metabolize aromatic amine bladder carcinogens, but the functional significance of NAT expression in the target organ is unclear. To resolve this issue, polygonal antisera against purified recombinant enzymes and C-terminal peptides of human NAT Type 1 (NAT1) and Type 2 (NAT2) were generated. Western blot analysis of exfoliated cells from human urine, pig bladder homogenate, and human bladder tumor-derived cell lines showed that NAT1

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GOODFELLOW, Geoffrey H., Jean-Marie DUPRET, and Denis M. GRANT. "Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2." Biochemical Journal 348, no. 1 (2000): 159–66. http://dx.doi.org/10.1042/bj3480159.

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The human arylamine N-acetyltransferases NAT1 and NAT2 catalyse the acetyl-CoA-dependent N- and O-acetylation of primary arylamine and hydrazine xenobiotics and their N-hydroxylated metabolites. We previously used a panel of recombinant NAT1/NAT2 chimaeric proteins to identify linear amino acid segments that have roles in imparting the distinct catalytic specificities to these proteins [Dupret, Goodfellow, Janezic and Grant (1994) J. Biol. Chem. 269, 26830-26835]. These studies indicated that a conserved central region (residues 112-210) distinct from that containing the active-site cysteine r

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Barker, David F., Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States, and David W. Hein. "Quantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the Rat." Drug Metabolism and Disposition 36, no. 12 (2008): 2445–51. http://dx.doi.org/10.1124/dmd.108.023564.

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Camporez, João Paulo, Yongliang Wang, Kasper Faarkrog, Natsasi Chukijrungroat, Kitt Falk Petersen, and Gerald I. Shulman. "Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice." Proceedings of the National Academy of Sciences 114, no. 52 (2017): E11285—E11292. http://dx.doi.org/10.1073/pnas.1716990115.

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A single-nucleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2) gene has recently been identified as associated with insulin resistance in humans. To understand the cellular and molecular mechanisms by which alterations in Nat2 activity might cause insulin resistance, we examined murine ortholog Nat1 knockout (KO) mice. Nat1 KO mice manifested whole-body insulin resistance, which could be attributed to reduced muscle, liver, and adipose tissue insulin sensitivity. Hepatic and muscle insulin resistance were associated with marked increases in both liver and muscle triglycer

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PEREIRA, Denise Soledade Peixoto, Bartira GUERRA-SANTOS, Silene Duarte Costa de MEDEIROS, Ricardo Castelo Branco ALBINATI, and Maria Consuêlo Caribé AYRES. "Comparação de metodologias utilizadas na análise dos parâmetros sanguíneos e da proteína total de tilápia do Nilo (Oreochromis niloticus)." Revista Brasileira de Saúde e Produção Animal 16, no. 4 (2015): 893–904. http://dx.doi.org/10.1590/s1519-99402015000400013.

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Resumo A hematologia em peixes contribui para a compreensão da fisiologia, relação filogenética, condições alimentares e outros parâmetros ecológicos. Este estudo comparou os efeitos dos anticoagulantes, ácido etilenodiaminotetraacético - EDTA e heparina, sobre os constituintes sanguíneos de tilápia do Nilo. Foram utilizados 25 animais com peso médio de 28,6 ± 13,0g para a colheita da amostra sanguínea e determinação do número de eritrócitos, concentração de hemoglobina, volume globular, proteínas totais, contagem total e diferencial de leucócitos e de trombócitos. Também foram comparadas algu

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Grut, Gustav. "“Ethics are generally not in play here”: The neutralization techniques of “the bad boy of pharma” Martin Shkreli." Nordisk Tidsskrift for Kriminalvidenskab 106, no. 3 (2019): 349–64. http://dx.doi.org/10.7146/ntfk.v106i3.124798.

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AbstractIn 2015, the American company Turing Pharmaceuticals increased the price of the drug Daraprim by 5,000 percent overnight. Politicians and healthcare representatives accused Turing’s CEO, Martin Shkreli, of having harmed both vulnerable patient groups and the healthcare system. The present article aims to attain an understanding of how Shkreli justified increasing the price and restricting the distribution of the drug Daraprim. Statements made by Shkreli in four video interviews were analyzed on the basis of Sykes and Matza’s (1957) theoretical framework of neutralization techniques. Al

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Zabłocki, Jan. ""Postumus" w "Noctes Atticae" Aulusa Gelliusa." Prawo Kanoniczne 40, no. 1-2 (1997): 255–62. http://dx.doi.org/10.21697/pk.1997.40.1-2.13.

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Dalle informazioni trasmesse da Gellio da un lato risulta che la legge delle dodici tavole considerava postumus un bambino nato al massimo nel decimo mese. Dall’altro, pero, egli riporta che Marco Varro rivolgeva l’attenzione alla necessita di diseredare il postumus sia nato nel decimo che nell’undicesimo mese. Inoltre nel I secolo, il pretore Lucio Papirio assegno l’eredità al postumus nato nel tredicesimo mese. Nello stesso modo si comporto l’imperatore Adriano nel II secolo. Si pone, quindi, la domanda se non esistesse la regola formulata nelle dodici tavole che come erede del morto veniva

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Minchin, R. F. "Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells." Biochemical Journal 307, no. 1 (1995): 1–3. http://dx.doi.org/10.1042/bj3070001.

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N-acetyl-p-aminobenzoylglutamate is a major urinary metabolite of folic acid. It is formed by acetylation of p-aminobenzoylglutamate following cleavage of the C9-N10 bond of folic acid. Using recombinant human type 1 (NAT1) and type 2 (NAT2) arylamine N-acetyltransferase, we have shown that p-aminobenzoylglutamate is a specific NAT1 substrate. At an acetyl-CoA concentration of 50 microM, the Km for p-aminobenzoylglutamate (pABG) acetylation by recombinant NAT1 was 130 +/- 13 microM. For the human pro-monocytic cell-line U937, the apparent Km was slightly higher (333 +/- 17 microM). Inhibitor s

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Родионова, Л. В., Л. Г. Самойлова, И. А. Шурыгина, et al. "Characteristics of acetylation reactions in patients with stenosing process of the lumbar spinal canal and dural sac depending on severity of Ligamentum flavum ossification." Nauchno-prakticheskii zhurnal «Patogenez», no. 3() (September 24, 2020): 45–52. http://dx.doi.org/10.25557/2310-0435.2020.03.45-52.

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Актуальность. В настоящее время совершенно не изучена экспрессия генов ацетилтрансфераз в структурах, участвующих в формировании патологического очага при развитии дегенеративно-дистрофических процессов в позвоночно-двигательном сегменте. Ведущая роль гипертрофии и оссификации жёлтой связки (Ligamentum flavum) в развитии и прогрессировании стенозирующих процессов позвоночного канала и дурального мешка, а также участие ацетилтрансфераз в метаболизме соединительной ткани определило цель исследования: выявить генетические особенности реакций ацетилирования у больных со стенозами позвоночного кана

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VEGIČ, VINKO. "POSREDOVANJE NATA V KRIZAH – IZKUŠNJE IN IZZIVI OPERACIJE V LIBIJI." CONTEMPORARY MILITARY CHALLENGES, VOLUME 2013/ ISSUE 15/1 (May 30, 2013): 11–29. http://dx.doi.org/10.33179//bsv.99.svi.11.cmc.15.1.1.

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Po izbruhu nemirov v Libiji v začetku leta 2011 so v Varnostnem svetu ZN sprejeli resolucijo, ki je zagotovila mandat za mednarodno posredovanje v Libiji. Dva dni po sprejetju resolucije so ameriške, britanske in francoske sile začele operacije za vzpostavitev embarga in območja prepovedi letenja nad Libijo. Konec marca je po- veljevanje in nadzor nad operacijo Združeni zaščitnik prevzel Nato, v njej so sodelo- vale vojaške sile 14 držav članic Nata in 4 partnerskih držav. Operacija je prispevala k zmanjšanju civilnih žrtev spopadov in pomagala opoziciji pri odstranitvi režima Moamerja Gadafij

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Mello, R. H., R. F. Martins, D. A. Bonissi, et al. "Haematological reference for red-browed parrot ( Amazona rhodocorytha , Salvadori, 1890) captive in the Atlantic Forest in Eastern Brazil." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 68, no. 5 (2016): 1275–82. http://dx.doi.org/10.1590/1678-4162-8600.

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ABSTRACT To conduct the survey were used 35 (thirty-five) red-browned parrots (A. rhodocorytha), adults, captive, of both genders and clinically healthy, belonging to the live collection of the Museum of Biology Teacher Mello Leitao, located in Santa Teresa, Espírito Santo, Brazil. Harvests were performed in the morning, by puncture of the brachial vein getting 0.5mL of blood stored in EDTA for a period no longer than 6 hours. Blood smears of fresh material were made at collection, stained using the method of May-Grunwald-Giemsa. Analysis of blood elements was done by cell counting in a mirror

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Trujillo, Elizabeth, Roberto Elias, Walter Silva, and David Montes. "Valores hematológicos de Bothrops atrox mantenidos en cautiverio en la ciudad de Lima." Salud y Tecnología Veterinaria 4, no. 2 (2018): 44. http://dx.doi.org/10.20453/stv.v4i2.3246.

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La serpiente venenosa Bothrops atrox, comúnmente llamado Jergón de la Selva, es una especie nativa de la Amazonía Peruana y causa la mayor cantidad de accidentes ofídicos a nivel nacional, razón por la cual se mantiene en cautiverio en instituciones del Estado para la producción del suero antiofídico y para la investigación de su veneno. Entre los meses de noviembre y diciembre del 2008 se realizó el estudio hematológico de 24 especímenes de B. atrox aparentemente sanos, mantenidos en cautiverio en el Instituto Nacional de Salud (INS) y en el Serpentario Oswaldo Meneses (UNMSM), ambos en la ci

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Dupret, J. M., G. H. Goodfellow, S. A. Janezic, and D. M. Grant. "Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2. Functional analysis of recombinant NAT1/NAT2 chimeras expressed in Escherichia coli." Journal of Biological Chemistry 269, no. 43 (1994): 26830–35. http://dx.doi.org/10.1016/s0021-9258(18)47094-9.

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Ðikić, Domagoj, Duje Lisičić, Sanja Matić-Skoko, et al. "Comparative hematology of wild Anguilliformes (Muraena helena, L. 1758, Conger conger, L. 1758 and Anguilla anguilla L. 1758)." Animal Biology 63, no. 1 (2013): 77–92. http://dx.doi.org/10.1163/15707563-00002395.

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The objective of this study was to compare circulating blood cell counts and morphology of three eel species: Muraena helena (moray), Conger conger (European conger) and Anguilla anguilla (European common eel). Moray and conger were collected from the Adriatic Sea at the Elaphite Islands near Dubrovnik, Croatia; common eels were collected in the Neretva River, Croatia. Hematological comparison was conducted using Natt-Harrick’s and May-Grünwald Giemsa staining methods. The hematocrit of moray and conger were similar, while common eel had higher values by 60%. Manual cell count showed that comm

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