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1

Mitscher, Lester A., Hanumaiah Telikepalli, Eva McGhee, and Delbert M. Shankel. "Natural antimutagenic agents." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 350, no. 1 (February 1996): 143–52. http://dx.doi.org/10.1016/0027-5107(95)00099-2.

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2

Valery M. Dembitsky, Tatyana A. Gloriozova, and Vladimir V. Poroikov. "Natural Peroxy Anticancer Agents." Mini-Reviews in Medicinal Chemistry 7, no. 6 (June 1, 2007): 571–89. http://dx.doi.org/10.2174/138955707780859396.

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3

Mohamed, Gamal A., Sabrin R. M. Ibrahim, Ehab S. Elkhayat, and Riham Salah El Dine. "Natural anti-obesity agents." Bulletin of Faculty of Pharmacy, Cairo University 52, no. 2 (December 2014): 269–84. http://dx.doi.org/10.1016/j.bfopcu.2014.05.001.

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4

Fan, H., C. M. Starks, H. Hughey, G. R. Eldridge, and J. F. Hu. "Natural anti-HCV agents." Drugs of the Future 34, no. 3 (2009): 223. http://dx.doi.org/10.1358/dof.2009.034.03.1344809.

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5

Haridas, V., and Sarala Naik. "Natural macromolecular antifreeze agents to synthetic antifreeze agents." RSC Advances 3, no. 34 (2013): 14199. http://dx.doi.org/10.1039/c3ra00081h.

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6

Benko, Jakub, and Stanislava Vranková. "Natural Psychoplastogens As Antidepressant Agents." Molecules 25, no. 5 (March 5, 2020): 1172. http://dx.doi.org/10.3390/molecules25051172.

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Increasing prevalence and burden of major depressive disorder presents an unavoidable problem for psychiatry. Existing antidepressants exert their effect only after several weeks of continuous treatment. In addition, their serious side effects and ineffectiveness in one-third of patients call for urgent action. Recent advances have given rise to the concept of psychoplastogens. These compounds are capable of fast structural and functional rearrangement of neural networks by targeting mechanisms previously implicated in the development of depression. Furthermore, evidence shows that they exert a potent acute and long-term positive effects, reaching beyond the treatment of psychiatric diseases. Several of them are naturally occurring compounds, such as psilocybin, N,N-dimethyltryptamine, and 7,8-dihydroxyflavone. Their pharmacology and effects in animal and human studies were discussed in this article.
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7

Nagle, Advait, Wooyoung Hur, and Nathanael Gray. "Antimitotic Agents of Natural Origin." Current Drug Targets 7, no. 3 (March 1, 2006): 305–26. http://dx.doi.org/10.2174/138945006776054933.

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8

Maity, B., and S. Chattopadhyay. "Natural Antiulcerogenic Agents: An Overview." Current Bioactive Compounds 4, no. 4 (December 1, 2008): 225–44. http://dx.doi.org/10.2174/157340708786847889.

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9

Dall'Acqua, Stefano. "Natural Products As Antimitotic Agents." Current Topics in Medicinal Chemistry 14, no. 20 (December 12, 2014): 2272–85. http://dx.doi.org/10.2174/1568026614666141130095311.

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10

Franco, Carlos Manuel, and Beatriz I. Vázquez. "Natural Compounds as Antimicrobial Agents." Antibiotics 9, no. 5 (April 29, 2020): 217. http://dx.doi.org/10.3390/antibiotics9050217.

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During the first two decades of this century, conventional antimicrobial compounds have been found out to have more bacterial resistance. What has also been worrying is the rediscovery of the so-called “natural compounds”, which in turn have a good name among the average citizen because of the former’s plant or animal origin. However, they do not form a well-classified group of substances. This Special Issue consists of five reviews focusing on clinical bacteria applications in food and their specific effects upon virulent bacterial factors. You will also find a research on much needed, new antimicrobials sourced in extreme environments, and secondary metabolites of Burkholderia. This issue includes 12 original research papers which will provide you with an in-depth coverage of the protein extract activity, as well as the activity of other plant extracts, on fighting bacteria, fungi or diarrhea. Their use in broilers or laying eggs for production purposes has also been focused on in order to improve gut microbiota. Last but not least, we should not forget about honey and its effect; Allium sativum-fermented extracts, as well as other “natural” compounds, have been studied in their fight against biofilms. Furthermore, we have also examined the use of essential oils, which are currently used in edibles such as fresh sausages. The present work also deals with other applications such as natural compound derivatives as well as compound mixtures.
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11

Venkatachalam, S., and S. Chattopadhyay. "Natural Radioprotective Agents: An Overview." Current Organic Chemistry 9, no. 4 (March 1, 2005): 389–404. http://dx.doi.org/10.2174/1385272053174930.

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12

Espinosa Aguirre, J. J. "Natural molecules as quimiopreventive agents." Toxicology Letters 259 (October 2016): S14—S15. http://dx.doi.org/10.1016/j.toxlet.2016.07.072.

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13

Das, Biswanath, and Gandham Satyalakshmi. "Natural Products Based Anticancer Agents." Mini-Reviews in Organic Chemistry 9, no. 2 (May 1, 2012): 169–77. http://dx.doi.org/10.2174/157019312800604706.

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14

Wall, Monroe E. "Antimutagenic Agents from Natural Products." Journal of Natural Products 55, no. 11 (November 1992): 1561–68. http://dx.doi.org/10.1021/np50089a002.

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15

Mann, John. "Natural products as immunosuppressive agents." Natural Product Reports 18, no. 4 (2001): 417–30. http://dx.doi.org/10.1039/b001720p.

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16

Yin, Mei-chin. "Development of natural antitumor agents." BioMedicine 3, no. 3 (September 2013): 105. http://dx.doi.org/10.1016/j.biomed.2013.06.001.

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17

Gyawali, Rabin, and Salam A. Ibrahim. "Natural products as antimicrobial agents." Food Control 46 (December 2014): 412–29. http://dx.doi.org/10.1016/j.foodcont.2014.05.047.

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18

Saqib, Uzma, Masood A. Khan, Manikandan Alagumuthu, Suraj P. Parihar, and Mirza S. Baig. "Natural compounds as antiatherogenic agents." Cellular and Molecular Biology 67, no. 1 (January 31, 2021): 177. http://dx.doi.org/10.14715/cmb/2021.67.1.27.

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19

Sampedro, Diego. "Natural and Artificial Photoprotective Agents." Molecules 26, no. 4 (February 23, 2021): 1189. http://dx.doi.org/10.3390/molecules26041189.

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20

Paarakh, Padmaa M., and Ravichandrian VD. "Natural Compounds as Anti Microbial Agents with In Silico Technique: A Review." International Journal of Pharma Research and Health Sciences 4, no. 4 (2016): 1252–60. http://dx.doi.org/10.21276/ijprhs.2016.04.02.

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21

Mani, Shalini, Geeta Swargiary, and Keshav K. Singh. "Natural Agents Targeting Mitochondria in Cancer." International Journal of Molecular Sciences 21, no. 19 (September 23, 2020): 6992. http://dx.doi.org/10.3390/ijms21196992.

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Mitochondria are the key energy provider to highly proliferating cancer cells, and are subsequently considered one of the critical targets in cancer therapeutics. Several compounds have been studied for their mitochondria-targeting ability in cancer cells. These studies’ outcomes have led to the invention of “mitocans”, a category of drug known to precisely target the cancer cells’ mitochondria. Based upon their mode of action, mitocans have been divided into eight classes. To date, different synthetic compounds have been suggested to be potential mitocans, but unfortunately, they are observed to exert adverse effects. Many studies have been published justifying the medicinal significance of large numbers of natural agents for their mitochondria-targeting ability and anticancer activities with minimal or no side effects. However, these natural agents have never been critically analyzed for their mitochondria-targeting activity. This review aims to evaluate the various natural agents affecting mitochondria and categorize them in different classes. Henceforth, our study may further support the potential mitocan behavior of various natural agents and highlight their significance in formulating novel potential anticancer therapeutics.
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22

Liu, E.-Hu, Lian-Wen Qi, Qian Wu, Yong-Bo Peng, and Ping Li. "Anticancer Agents Derived from Natural Products." Mini-Reviews in Medicinal Chemistry 9, no. 13 (November 1, 2009): 1547–55. http://dx.doi.org/10.2174/138955709790361520.

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23

Chen, Q. F., Z. P. Liu, and F. P. Wang. "Natural Sesquiterpenoids as Cytotoxic Anticancer Agents." Mini-Reviews in Medicinal Chemistry 11, no. 13 (November 1, 2011): 1153–64. http://dx.doi.org/10.2174/138955711797655399.

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24

Hammad, Mahmoud. "Natural antifungal agents for food preservation." Benha Veterinary Medical Journal 39, no. 1 (October 1, 2020): 80–84. http://dx.doi.org/10.21608/bvmj.2020.26306.1191.

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25

Silver, L. L. "NATURAL PRODUCT SCREENING FOR ANTIBACTERIAL AGENTS." Acta Horticulturae, no. 709 (May 2006): 115–24. http://dx.doi.org/10.17660/actahortic.2006.709.13.

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26

Kumar, Ajay, P. K. Pareek, D. B. Shakyawar, and V. V. Kadam. "Colourless natural antimoth agents for woollens." Indian Journal of Small Ruminants (The) 23, no. 1 (2017): 73. http://dx.doi.org/10.5958/0973-9718.2017.00020.4.

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27

XIA, Xuan, and Jianping WENG. "Targeting metabolic syndrome: Candidate natural agents." Journal of Diabetes 2, no. 4 (November 21, 2010): 243–49. http://dx.doi.org/10.1111/j.1753-0407.2010.00090.x.

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28

Caniato, R., and L. Puricelli. "Review: Natural Antimalarial Agents (1995-2001)." Critical Reviews in Plant Sciences 22, no. 1 (January 2003): 79–105. http://dx.doi.org/10.1080/713610851.

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29

El Sayed, Khalid A., Piotr Bartyzel, Xiaoyu Shen, Tony L. Perry, Jordan K. Zjawiony, and Mark T. Hamann. "Marine Natural Products as Antituberculosis Agents." Tetrahedron 56, no. 7 (February 2000): 949–53. http://dx.doi.org/10.1016/s0040-4020(99)01093-5.

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30

Surh, Young-joon. "M11-03: Natural agents for chemoprevention." Journal of Thoracic Oncology 2, no. 8 (August 2007): S184—S185. http://dx.doi.org/10.1097/01.jto.0000282963.30308.d8.

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31

DOBLER, M. "ChemInform Abstract: Natural Cation-Binding Agents." ChemInform 28, no. 8 (August 4, 2010): no. http://dx.doi.org/10.1002/chin.199708285.

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32

Ireland, David C., Conan K. L. Wang, Jennifer A. Wilson, Kirk R. Gustafson, and David J. Craik. "Cyclotides as natural anti-HIV agents." Biopolymers 90, no. 1 (November 15, 2007): 51–60. http://dx.doi.org/10.1002/bip.20886.

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33

Witzany, Guenther. "The agents of natural genome editing." Journal of Molecular Cell Biology 3, no. 3 (April 1, 2011): 181–89. http://dx.doi.org/10.1093/jmcb/mjr005.

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34

Khazir, Jabeena, Darren L. Riley, Lynne A. Pilcher, Pieter De-Maayer, and Bilal Ahmad Mir. "Anticancer Agents from Diverse Natural Sources." Natural Product Communications 9, no. 11 (November 2014): 1934578X1400901. http://dx.doi.org/10.1177/1934578x1400901130.

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This review attempts to portray the discovery and development of anticancer agents/drugs from diverse natural sources. Natural molecules from these natural sources including plants, microbes and marine organisms have been the basis of treatment of human diseases since the ancient times. Compounds derived from nature have been important sources of new drugs and also serve as templates for synthetic modification. Many successful anti-cancer drugs currently in use are naturally derived or their analogues and many more are under clinical trials. This review aims to highlight the invaluable role that natural products have played, and continue to play, in the discovery of anticancer agents.
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35

Kerr, Russell G., and Stacey S. Kerr. "Marine natural products as therapeutic agents." Expert Opinion on Therapeutic Patents 9, no. 9 (September 1999): 1207–22. http://dx.doi.org/10.1517/13543776.9.9.1207.

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36

Suzzi, Giovanna, Patrizia Romano, I. Ponti, and Carla Montuschi. "Natural wine yeasts as biocontrol agents." Journal of Applied Bacteriology 78, no. 3 (March 1995): 304–8. http://dx.doi.org/10.1111/j.1365-2672.1995.tb05030.x.

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37

Xiaoqiu xiao, Priyankashukla. "Marine Natural Products As Anticancer Agents." IOSR Journal of Pharmacy and Biological Sciences 9, no. 2 (2014): 60–64. http://dx.doi.org/10.9790/3008-09246064.

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38

Talmadge, James E. "Natural product derived immune-regulatory agents." International Immunopharmacology 37 (August 2016): 5–15. http://dx.doi.org/10.1016/j.intimp.2016.02.025.

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39

Witzany, Guenther. "Agents Competent in Natural Genetic Engineering." Biosemiotics 5, no. 2 (January 27, 2012): 291–96. http://dx.doi.org/10.1007/s12304-012-9141-9.

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40

Derda, Monika, Edward Hadaś, and Barbara Thiem. "Plant extracts as natural amoebicidal agents." Parasitology Research 104, no. 3 (December 3, 2008): 705–8. http://dx.doi.org/10.1007/s00436-008-1277-9.

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41

Kovačević, Zorana, Miodrag Radinović, Ivana Čabarkapa, Nebojša Kladar, and Biljana Božin. "Natural Agents against Bovine Mastitis Pathogens." Antibiotics 10, no. 2 (February 19, 2021): 205. http://dx.doi.org/10.3390/antibiotics10020205.

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Bovine mastitis is the most widespread and economically important disease worldwide. The present study aimed to determine bioactive compounds in two essential oils (EOs) from wild (Thymus serpyllum) and common thyme (Thymus vulgaris) and to assess the antioxidant potential as well as antibacterial efficacy of the EOs against mastitis-associated bacteria. The study also included antibiotic susceptibility tests. The strains were previously isolated from lactating animals with clinical and subclinical mastitis. The antioxidant potential of the commercial EOs of wild and common thyme was evaluated by five in vitro assays. The antibacterial activity was performed using the microdilution technique, while antibiotic susceptibility testing was performed by the Kirby–Bauer disc diffusion method. The dominant compound in wild thyme was thymol (45.22%), followed by p-cymene (23.83%) and γ-terpinene (3.12%), while in common thyme, it was thymol (54.17%), followed by γ-terpinene (22.18%) and p-cymene (16.66%). Among the fourteen mastitis-associated bacteria, strain IX Streptococcus spp. (β-hemolytic) was the most sensitive to the tested EOs (minimum inhibitory concentration (MIC)/minimal bactericidal concentration (MBC) were 0.78/1.56 and 0.39/0.78 mg/mL for T. serpyllum (TS) and T. vulgaris (TV), respectively). Regarding Streptococcus spp. β heamoliticus, MICs for TS ranged from 0.78 to 1.56 mg/mL, while for the same oil, MBCs ranged from 1.56 to 12.5 mg/mL. In the case of T. vulgaris, MICs ranged from 0.39 to 3.125 mg/ mL, while MBCs ranged from 3.125 to 6.25 mg/mL. TV is more active against E. coli, E. sakazakii, and Streptococcus spp., while it is less effective against Staphylococcus spp. than TS. The study revealed that the tested EOs possess remarkable antioxidative and antibacterial activities and could be used in the development of pharmaceutical formulation as an alternative to conventional mastitis therapy.
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42

Swayambhu, Girish, Michael Bruno, Andrew M. Gulick, and Blaine A. Pfeifer. "Siderophore natural products as pharmaceutical agents." Current Opinion in Biotechnology 69 (June 2021): 242–51. http://dx.doi.org/10.1016/j.copbio.2021.01.021.

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43

Alves, Celso, and Marc Diederich. "Marine Natural Products as Anticancer Agents." Marine Drugs 19, no. 8 (August 4, 2021): 447. http://dx.doi.org/10.3390/md19080447.

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44

Sarkar, Ajoy K., and Renuka Dhandapani. "Study of Natural Colorants as Antibacterial Agents on Natural Fibers." Journal of Natural Fibers 6, no. 1 (March 6, 2009): 46–55. http://dx.doi.org/10.1080/15440470802704370.

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45

Fennimore, Anne. "Natural born opportunists." Management Decision 55, no. 8 (September 18, 2017): 1629–44. http://dx.doi.org/10.1108/md-11-2016-0786.

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Purpose The purpose of this paper is to adapt research conducted on subclinical psychopaths and Machiavellians to conceptualise false agents in transaction cost economics (TCE). Both opportunism and information asymmetry provide a means to manipulate contractual relationships, pursuing existing loopholes for self-interest, while uncertainty and small-numbers bargaining allow false agents to exploit existing agreements during periods of rapid change, growth, and development. Considering differences in contract length preference may inform our understanding of subclinical psychopaths and Machiavellians. Contextually, the rise of “quasi-governmental” hybrid organisations may produce an ideal prospect for “natural born” opportunists to reap self-interested benefits through contractual loopholes. Design/methodology/approach This theoretical paper addresses social norms and blind trust in contractual relationships. In turn, blind trust may provide clues about the environmental conditions that facilitate manipulation by subclinical psychopaths and Machiavellians during negotiations of contract term length. Findings Williamson’s (1975) TCE framework provides a novel approach to subclinical psychopathic and Machiavellian behaviour by agents. Assumptions about behavioural norms may differ between the contracting party and the agent, leading to positive behavioural expectations of trust such as confidence, reciprocity, and history. The length of the contractual relationship may distinguish subclinical psychopaths from Machiavellians. The subclinical psychopath is more likely to behave opportunistically in short-term contracts, while Machiavellians more likely amass goodwill to behave opportunistically in long-term contracts. The role of uncertainty, small-numbers bargaining, information asymmetry, and opportunism is particularly relevant in quasi-governmental organisations when agents are “natural born” opportunists. Originality/value This theoretical paper adds to discussion of TCE related problems in organisations. “Natural born” opportunistic agents are more likely to take advantage of principals who extend trust as a goodwill gesture in a contractual relationship. Trust often represents a mental shortcut, based on “gut” reactions to save time, especially in dynamic environments. Hybrid organisations represent one such environment, in which contracting of goods and services renders comprehensive monitoring impracticable. Yet, scholarship adheres to legal mechanisms as safeguards against opportunism without acknowledging social norms that guide blind trust. Finally, contrasting motives between principals and false agents creates an inherent relationship asymmetry.
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46

Termentzi, Aikaterini, Nikolas Fokialakis, and Alexios Leandros Skaltsounis. "Natural Resins and Bioactive Natural Products thereof as Potential Anitimicrobial Agents." Current Pharmaceutical Design 17, no. 13 (May 1, 2011): 1267–90. http://dx.doi.org/10.2174/138161211795703807.

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47

Wang, Liyan, Junfeng Wang, Lishu Wang, Shurong Ma, and Yonghong Liu. "Anti-Enterovirus 71 Agents of Natural Products." Molecules 20, no. 9 (September 9, 2015): 16320–33. http://dx.doi.org/10.3390/molecules200916320.

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48

Smit, Nico, Jana Vicanova, and Stan Pavel. "The Hunt for Natural Skin Whitening Agents." International Journal of Molecular Sciences 10, no. 12 (December 10, 2009): 5326–49. http://dx.doi.org/10.3390/ijms10125326.

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49

Valeriote, Fred, Thomas Corbett, Patricia Lorusso, Richard E. Moore, Paul Scheuer, Gregory Patterson, Valerie Paul, et al. "Discovery of Anticancer Agents from Natural Products." International Journal of Pharmacognosy 33, sup1 (January 1995): 59–66. http://dx.doi.org/10.3109/13880209509067088.

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50

Patel, N., R. Mishra, N. Patel, and P. Barad. "Some Natural Isolated Compounds as Anticancer Agents." PharmaTutor 6, no. 11 (January 11, 2018): 22. http://dx.doi.org/10.29161/pt.v6.i11.2018.22.

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