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Dissertations / Theses on the topic 'Natural bioactive'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Woods, Katherine B. "Bioactive natural products." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/26234.

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Montbretins A-E were isolated from the corms of Crocosmia sp., an invasive perennial plant. The montbretins are inhibitors of human pancreatic α-amylase (HPA). Montbretin A (2- 30) is a competitive inhibitor of HPA with a K₁ of 1.3 nM. The activity of the other family members varied significantly and provided structure-activity information. Saturation Transfer Difference (STD) NMR spectroscopy was used to determine that the caffeic acid region of the montbretins is important for binding. HPA is involved in the breakdown of complex carbohydrates; inhibition of this enzyme could help with regula

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2

Desjardine, Kelsey Lorne. "Bioactive marine natural products." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31286.

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The chemical exploration of extracts from cultures of the marine bacterial isolate PNG-276 yielded the novel antibiotic tauramamide (2.13), a non-ribosomal peptide active against cultures of Enterococcus sp. and methicillin-resistant Staphylococcus aureus (MRSA). A study of extracts of the marine sponge Spirastrella coccinea yielded the novel macrolide methylspirastrellolide C (3.14), which is active against protein phosphatase 2A (PP2A). A third study examined sponge extracts active in a cannabinoid receptor assay, yielding two known compounds, an A- nor -steroid derivative (4.10) and bengami

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3

Zheng, Zehua. "Synthesis of bioactive natural products." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59815.

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Crude extracts of the rare macrofungus Serpula sp. collected from a wooded area in Sri Lanka showed antimicrobial activity. The novel fungal metabolite serpulanine (2.1) was isolated from the crude extract in very small amounts along with a number of additional secondary metabolites. In order to obtain sufficient quantities of serpulanine (2.1) for biological evaluation, a synthetic route was developed to the natural product and a small library of analogs that have been evaluated in a panel of bioassays. Serpulanine (2.1) inhibits the histone deacetylase I/II with a clear dose response curve.

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4

Brastianos, Harry Charilaos. "Bioactive natural products from nature." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/3960.

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Bioassay guided fractionation of a crude extract of the marine sponge Neopetrosia exigua resulted in the first reported isolation of exiguamines A and B. These pyrroloquinone alkaloids have an unprecedented hexacyclic skeleton that has not been previously encountered in natural products. Biological studies have identified exiguamine A as a potent in vitro inhibitor of the enzyme indoleamine-2,3-dioxygenase (IDO). IDO is an enzyme expressed by tumor cells to evade the immune system. Inhibitors against this enzyme may allow the immune system to attack cancer cells, making this enzyme a potential

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5

Li, Guoqiang. "Structure elucidation of bioactive natural products." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/NQ29469.pdf.

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6

Du, Yongle. "Discovery and Delivery of Bioactive Natural Products." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/83762.

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As a part of search for bioactive natural products from the plants in collaboration with the Natural Products Discovery Institute (NPDI), ten plant extracts were investigated for their antiplasmodial activity against Plasmodium falciparum Dd2 strain. Twenty-eight compounds were isolated, and twelve of them were new compounds. The structures of all these compounds were determined by analysis of their mass spectrometric, 1D and 2D NMR, and ECD spectrum. Among these natural products, there were three compounds with good antiplasmodial activity, trichospirolide A with an IC50 value of 1.5 μM, mall

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7

Jangir, R. "Homophthalic anhydride derivatives to bioactive natural products." Thesis(Ph.D.), CSIR- National Chemical Laboratory,Pune, 2016. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2105.

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8

Heltzel, Carl E. "Structural and synthetic studies of bioactive natural products." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/40067.

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Bioassay directed fractionation of the methyl ethyl ketone extract of Crescentia cujete resulted in the isolation of nine bioactive compounds, and detailed spectroscopic interpretation led to the assignment of their structures as (2S,3S)-3-hydroxy-5,6-dimethoxy dehydroiso-α-Iapachone [2.10], (2R)-5,6- dimethoxydehydroiso-α-Iapachone [2.11], (2R)-5-methoxy dehydroiso-alapachone [2.12], 5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b ]furan-4,9-dione [2.13], 2-(1 '-hydroxyethyl)naphtho[2,3-b ]furan-4,9-dione [2.14]' 2-isopropenylnaphtho[ 2,3-b ]furan-4,9-dione [2.15], 5-hydroxydehydro-iso-a-Iapachone

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9

Tang, Shoubin. "Structural and Synthetic Studies of Bioactive Natural Products." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/26104.

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As part of an ongoing investigation for anticancer agents from natural resources, four plant extracts were determined to contain interesting bioactivity. These extracts were separated by chromatography to afford a number of bioactive compounds that were characterized by spectral analysis. Fractionation of the fruit extract of Cryptocarya crassifolia led to the isolation of two known flavonoids and two known cryptocaryalactones. Fractionation of the bark extract of the same plant also gave the same two cryptocaryalactones. All these compounds were weakly active in a cytotoxicity assay.

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10

Gogoi, S. "Studies on total synthesis of bioactive natural butyrolactones." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2008. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2636.

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11

Casanova, Martí Àngela. "Action of natural bioactive compounds on the enteroendocrine system." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/460759.

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En els últims anys ha augmentat la presència de l’obesitat i de malalties associades a aquesta. En vista d’aquest fet, la cerca de teràpies preventives així com tractaments per aquestes malalties esdevé de gran interès per la salut publica. Les hormones intestinals secretades per les cèl•lules enteroendocrines juguen un paper clau en la regulació de la ingesta i la homeòstasis de la glucosa. En aquest marc, la recerca d’aquesta tesi doctoral s’ha centrat en l’acció dels compostos naturals bioactius sobre el sistema enteroendocrí. En estudis previs, el nostre grup de recerca va observar que u

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12

Pereira, Alban R. "Marine natural products : synthesis and isolation of bioactive analogues." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/7526.

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Tauramamide (2-12), a linear acylpentapeptide recently isolated from cultures of Brevibacillus laterosporus (PNG-276) collected in Papua New Guinea, was synthesized in 9 steps and 29% overall yield. Besides confirming the proposed structure, synthetic (2-12) allowed the antimicrobial assessment of this novel antibiotic. Additionally, a new analogue of the surfactin depsipeptides family named dealkylsurfactin (2-48), was prepared in 10 steps and 14% overall yield. The compound was employed as a biological tool in binding studies between the mitotic regulator isomerase Pinl and the microtubule-a

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13

Daoust, Julie. "Isolation and structure elucidation of bioactive marine natural products." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37536.

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Clionamines A-D (2.6-2.9) are new aminosteroids isolated from South African specimens of the sponge Cliona celata. All four compounds (2.6-2.9) are activators of autophagy in MCF-7 cells. Autophagy is a catabolic process that plays an important role in maintaining cellular homeostasis. Autophagy is also directly involved in the removal of bacterial and viral antigens and in the development of cancerous tumors. The novel sesterterpenoid ansellone A (3.4) was isolated from the nudibranch Cadlina luteomarginata and was later found to have been sequestered by the nudibranch from the sponge Phorbas

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14

Clement, Jason Anderson. "Studies of Bioactive Natural Products and Mechanism-Based Bioassays." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/29879.

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An extract of the sponge <i>Rhabdastrella globostellifera</i> was active in an assay measuring stabilization of the binding of DNA with DNA polymerase β. From this extract, four isomalabaricane triterpenoids were isolated and characterized, three of which were active in the binding assay. All compounds were active in the A2780 ovarian cancer cell line assay. Bioassay-guided fractionation of an extract of a sponge of species <i>Dysidea</i> using the A2780 bioassay yielded the known scalarane sesterterpenoid heteronemin in good yield. Four derivatives of heteronemin were prepared s

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Stapleton, Bronwin Louise. "Structural studies of bioactive natural products from marine invertebrates /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16452.pdf.

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16

Hagos, Selam. "Chemical Investigation of Bioactive Marine Extracts." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7301.

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Natural products have been a fundamental source of medicinal scaffolds for decades; with sixty percent of marketed drugs. Many synthetic chemists are focused on synthesizing potent and nontoxic compounds for pharmaceutical targets, however, nature is still proving to be a source of new bioactive compounds. Produced by the host organism for defense, reproduction and communication, secondary metabolites also demonstrate promising bioactivity against human pathogens. Hence, natural product chemists continue their quest for new leads. As a continuation

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17

Yan, Luping. "Bioactive marine natural products : analogue synthesis, SAR, and target identification." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50069.

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3,6,7-trihydroxycoumarin C11 (2.14) was first isolated from the green alga Dasycladus vermicularis in 1983. C11 and 3,7,8-trihydroxycoumarin C21 (2.15), alongside their precursors C12 (2.18) and C22 (2.20), were synthesized for a target-based screen for anti-HCV drugs, where ideal hits eliminate fluorescence signals by inhibiting the proteolytic activity of HCV NS3pro/Pep4A against a synthetic peptide “BS-IQFS”. With C12 and C22 serving as negative controls, C11 and C21 inhibited the NS3pro/Pep4A activity in vitro. The IC₅₀’s of C11 and C21 were 3.07 μM and 2.10 μM, respectively. A bioassay-g

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18

Forestieri, Roberto. "Isolation, structure elucidation, and total synthesis of bioactive natural products." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45668.

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19

Xiang, Jie. "Functional genomic study and bioinformatic analysis on natural bioactive peptides." Thesis, Queen's University Belfast, 2017. https://pure.qub.ac.uk/portal/en/theses/functional-genomic-study-and-bioinformatic-analysis-on-natural-bioactive-peptides(4c3d14a3-7484-463b-8c82-cdc9abc5052e).html.

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An extraordinary diverse components of animal toxins have emerged along with the long-term evolution of animals, which have unique functions that protect them to survive in the wild. Specifically, the granular glands of amphibians contain multiple chemical compounds, among which, peptides are one of the major types of the constituents. This thesis is divided into six chapters. Chapter 1, as general introduction, describes the detailed background on peptide-based therapeutic agents, the promising therapeutic application of animal toxins, and a brief review on anuran skins and their secretions.

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20

Almaliti, Jehad S. "Natural Products-Inspired Synthesis and Biological Evaluation of Bioactive Agents." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384555204.

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21

Dischler, Nicole Marie. "Investigations of targeted natural sources in search of bioactive metabolites." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6725.

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The past several decades have seen a rise in the numbers of fungal infections due to an increase in the population of immune-compromised individuals. Some of the most common types of invasive fungal infections are caused by Candida, Aspergillus, and Cryptococcus species. The current treatments for systemic fungal infections remain unsatisfactory because of resistance and toxicity problems. Because of this, there is a growing need for classes of antifungal agents effective against these pathogens. Fungi have proven to be an excellent source of novel secondary metabolites possessing a range of b

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22

Vaidya, S. D. "Studies on total synthesis of bioactive natural and unnatural quinazolinones." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2016. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2080.

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23

Wangchuk, Phurpa. "Bioactive alkaloids from medicinal plants of Bhutan." Thesis, Department of Chemistry - Faculty of Science, 2004. http://ro.uow.edu.au/theses/315/.

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Natural products had been indispensably used by many cultures and traditions in folklore medicines for thousands of years. These traditional medicines cater to about 85% of the world population for their primary health care needs. Natural products have been intensively explored also for their bioactive pharmacophores by modern pharmaceutical companies. In fact they are the skeletal framework of about 60% of the modern drugs that are available today. Of these, about 80% of antibacterial drugs and 90% of antimalarial drugs are natural derivatives. One of the interesting secondary metabolite grou

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24

Wangchuk, Phurpa. "Bioactive alkaloids from medicinal plants of Bhutan." Department of Chemistry - Faculty of Science, 2004. http://ro.uow.edu.au/theses/315.

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Natural products had been indispensably used by many cultures and traditions in folklore medicines for thousands of years. These traditional medicines cater to about 85% of the world population for their primary health care needs. Natural products have been intensively explored also for their bioactive pharmacophores by modern pharmaceutical companies. In fact they are the skeletal framework of about 60% of the modern drugs that are available today. Of these, about 80% of antibacterial drugs and 90% of antimalarial drugs are natural derivatives. One of the interesting secondary metabolite grou

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25

Stout, Elizabeth Paige. "Discovery and synthesis of bioactive natural product probes from marine systems." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37301.

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Flora and fauna from terrestrial and marine environments provide libraries of natural compounds for drug discovery. The last four decades have seen major advances in ocean exploration that have allowed chemists and biologists to explore previously inaccessible and rare marine organisms. The study of under-explored marine organisms can result in the discovery of structurally novel and unusual natural products with drug potential. Prior to 2005, no natural products had been reported from the Fijian red macroalgae Callophycus serratus or Neurymenia fraxinifolia. As a result of the work described

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26

Boot, Claudia M. "Marine-derived fungi : an effective source of novel bioactive natural products /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2007. http://uclibs.org/PID/11984.

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27

Montgomery, Laura Jane. "Investigations of the biosynthesis and biomimetic synthesis of bioactive natural products." Thesis, University of Warwick, 2008. http://wrap.warwick.ac.uk/4420/.

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This thesis describes work towards the biomimetic synthesis and understanding the biosynthesis of two families of natural products: prodiginines and quartromicins. Prodiginines are a large family of red pigmented tripyrrole antibiotics. Although they have not been used clinically, the promising anti-cancer, immunosuppressive and antimalarial activity they display at non-toxic doses has generated renewed interest in their utilisation. The synthesis of an analogue of the proposed pyrrole-2-carboxyl-RedO intermediate in prodiginine biosynthesis has been achieved. The resulting NAC thioester and a

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28

Stevens, Kiri. "Methodology for the synthesis of NP25302 and other bioactive natural products." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:ae18879e-d75e-4280-ba55-1ae08e64034f.

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Total synthesis of the pyrrolizidine alkaloid NP25302: (+)-NP25302 is an unusual vinylogous urea containing pyrrolizidine alkaloid shown to exhibit cell adhesion inhibition. It was envisaged that this natural product could be accessed by a novel 5-endo-dig cyclisation to construct the pyrrolizidine core, and a Curtius rearrangement to install the vinylogous urea motif. This methodology was first tested on a model system, furnishing nor-NP25302 from L-proline in 12 steps and 9% overall yield. The total synthesis of (±)-NP25302 was completed in 9 steps and 26% overall yield from ethyl 2-nitropro

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29

Berger, John Michael. "Isolation, Characterization, and Synthesis of Bioactive Natural Products from Rainforest Flora." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/28086.

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As part of our ongoing investigations for anticancer drugs from rainforestflora, five plant extracts were determined to contain interesting bioactivity. These extracts were subjected to various separation techniques, affording a number of bioactive compounds that were then characterized by spectral and degradative methods. A methanol extract of Cestrum latifolium Lam. yielded the known compound parissaponin Pb. Hydrolysis afforded its aglycone, the known spirostanol diosgenin. GCMS analysis characterized the derivatized, hydrolyzed sugars. Previous investigations of Albizia subdimidiata pr

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30

Rapson, Trevor Douglas. "Bioactive 4-methoxypyrrolic natural products from two South African marine invertebrates." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1006766.

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This thesis presents an investigation of the 4-methoxypyrrolic constituents of two South African marine invertebrates, the nudibranch Tambja capensis and the bryozoan Bugula dentata. Three known compounds tambjamine A (7), tambjamine E (13) and the tetrapyrrole (15) were isolated during this investigation. All three compounds were shown to be active against oesophageal cancer in accordance with the general anticancer and immunosuppressive properties observed for 4-methoxypyrrolic natural products. Tambjamine A (7), tambjamine E (13) and the tetrapyrrole (15), together with tambjamine K (21) an

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31

Tran, Wendy. "Synthesis of Bioactive Natural Products & Derivatives as Novel Anti-infectives." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23995.

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Throughout history natural products have served as a valuable resource for the treatment of various diseases. To this day, many of these ancient remedies and their derivatives are still in use. However, in recent years, antibiotic discovery has stagnated at a time where there has also been the alarming emergence of antibiotic resistance which threatens to undermine the effectiveness of existing therapies. As such, novel antimicrobial agents are urgently needed that possess unique mechanisms of action to those currently in use. A promising class of natural products that exhibit antimicrobial ac

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32

Pérez, Hemphill Catalina Francis [Verfasser]. "Bioactive fungal natural products from extremophilic endophytes / Catalina Francis Pérez Hemphill." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1125595418/34.

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33

ZHANG, XIN. "Surface functionalization of bioactive glasses with natural molecules of biological significance." Doctoral thesis, Politecnico di Torino, 2014. http://hdl.handle.net/11583/2535899.

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Natural or artificial materials used for replacement or supplement the functions of living tissues, termed as biomaterials, may be bioinert (i.e. alumina and zorconia,) resorbable (i.e. tricalcium phosphate), bioactive (i.e. hydroxyapatite, bioactive glasses, and glass-ceramics) or porous for tissue ingrowth (i.e. hydroxyapatite-coated metals). Among all the biomaterials, bioactive glass and glass-ceramics are widely used in orthopedic and dental applications and are being developed for tissue engineering. However, to a large extent, the behavior and overall performance of biomaterials are gov

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34

Batwal, Ramesh U. "Studies on chemical and chemoenzymatic total synthesis of bioactive natural products." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2015. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2032.

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35

Wang, Siyuan. "Engineering of polyketide biosynthetic pathways for bioactive molecules." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4684.

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Polyketides are a large group of structurally diverse natural products that have shown a variety of biological activities. These molecules are synthesized by polyketide synthases (PKSs). PKSs are classified into three types based on their sequence, primary structure, and catalytic mechanism. Because of the bioactivities of polyketide natural products, this study is focused on the engineering of PKS pathways for efficient production of useful bioactive molecules or structural modification to create new molecules for drug development. One goal of this research is to create an efficient method to

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36

Ashour, Mohamed A. A. "Structure elucidation of bioactive marine natural products using modern methods of spectroscopy." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982523963.

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37

Carr, Gavin. "Bioactive marine natural products : isolation, structure elucidation and synthesis of pharmacophore analogues." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23166.

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Bioassay-guided fractionation of the marine sponge Spongia irregularis led to the isolation of a new sulfated sesterterpenoid, irregularasulfate (2.16), along with two known sulfated sesterterpenoids, halisulfate 7 (2.14) and hipposulfate C (2.15). All three compounds (2.14-2.16) inhibit the related phosphatases calcineurin, PP1 and PP2A. The analogue 2.23 was synthesized and showed similar phosphatase inhibitory activity to the natural products. One new bafilomycin analogue, bafilomycin F (3.2), along with three known bafilomycin analogues, bafilomycin A1 (3.1), bafilomycin B1 (3.3) and ba

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Meimetis, Labros George. "Function oriented synthesis of bioactive marine natural products and their pharmacophore analogues." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42710.

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Natural products play a central role in drug discovery. The Andersen lab focuses its efforts on the isolation and structure elucidation of compounds from the marine environment. Many of these compounds possess biological activity, and often their total synthesis is undertaken, to provide structure-activity relationship (SAR) studies for new pharmacophores, and to provide material to probe in vivo biological effects. Several projects probing the biological activities of natural products and their analogues by synthesis were completed. It has been proposed that small molecule activators of SHIP1

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Ahmad, Mansoor. "Investigations into the isolation, structure elucidation and biosynthesis of bioactive natural products." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/43414/.

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This project is divided into two parts. The first part of the project involved the investigation of fish toxins produced by Streptomyces species. Samples for fishexposure experiments were prepared from an actinomycete belonging to the S. griseus clade isolated from a site of major fish kills, as well as from the type strain, Streptomyces griseus DSM 40236. Fish-exposure samples were prepared through a series of consecutive HPLC separations. We were able to narrow down the highest level of fish toxicity to four fractions, each containing only a handful of compounds. Comparison of the metabolic

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Schwaid, Adam. "Discovery and Characterization of Novel Bioactive Peptides and a Natural ERRalpha Ligand." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11138.

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Metabolites and peptides have a central role in biology that is often overlooked. Despite the importance of metabolites in key protein-metabolite interactions (PMIs), the extent and identity of these interactions is not known. Likewise, the extent to which short open reading frames (sORFs) in the genome are translated into peptides has also been an elusive question. This dissertation describes the development and application of methods to elucidate unknown molecules and interactions critical to understanding biology, and the subsequent characterization of the biological roles of these disco

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Rubio, Brent Kawika. "Bioactive natural products for global health from Papua New Guinea marine sponges /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2008. http://uclibs.org/PID/11984.

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Protti, Michele <1986&gt. "Hyphenated Approaches for the Analysis of Bioactive Natural Compounds in Complex Matrices." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7520/1/Tesi_PhD_Michele_Protti.pdf.

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Plants, animals and micro-organisms represent a reservoir of natural products, the so called “natural source-derived compounds”. This is particularly true for the plant kingdom, as it offers a variety of species still used as remedies for several diseases in many parts of the world. Nevertheless, the bioactive potential of many plant species remains largely unexplored. Thus, biodiversity represents an unlimited source of chemical entities with potential beneficial effects on human health. These compounds are usually secondary metabolites often present in low quantity in plant material and thei

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Protti, Michele <1986&gt. "Hyphenated Approaches for the Analysis of Bioactive Natural Compounds in Complex Matrices." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7520/.

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Plants, animals and micro-organisms represent a reservoir of natural products, the so called “natural source-derived compounds”. This is particularly true for the plant kingdom, as it offers a variety of species still used as remedies for several diseases in many parts of the world. Nevertheless, the bioactive potential of many plant species remains largely unexplored. Thus, biodiversity represents an unlimited source of chemical entities with potential beneficial effects on human health. These compounds are usually secondary metabolites often present in low quantity in plant material and thei

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Solana, Ciprés Miriam. "Supercritical CO2 technologies for the production of bioactive compounds from natural sources." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424461.

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This Ph.D. project was aimed to evaluate the potential of supercritical CO2 technologies for obtaining natural extracts rich in bioactive compounds from residual agricultural biomass and microalgae. Three different supercritical CO2 techniques have been investigated with the purpose of optimizing the operating conditions and assessing the possibility to obtain the desired products in a safe, green and efficient way. First, attention has been focused on supercritical CO2 extraction (SFE). Experimental work regarding essential fatty acids extraction from microalgae and the application of solubi

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Mahajan, P. S. "Synthesis of bioactive natural products cleistenolide, isocryptolepine and circumdatins using novel methodologies." Thesis(Ph.D.), CSIR- National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/4511.

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Demerdash, Amr El. "Isolation of Bioactive Marine Natural Products and Bioinspired Synthesis of Fused Guanidinic Tricyclic Analogues." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS088.

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Le travail réalisé dans cette thèse a consisté en deux parties principales; la première partie a été centrée sur l’isolement de métabolites marins bioactifs, en mettant l'accent sur l'utilisation de techniques intégrés et modernes pour l'exploration chimique de deux éponges marines sélectionnées pour leurs activités cytotoxiques et antiinfectieuses. L’inhibition du Quorum Sensing pour explorer les activités antibiofilms a été utilisée. L’étude chimique de la première éponge Monanchora sp., a permis l'isolement et l'identification de vingt-huit composés guanidiniques et polycycliques, dont onze

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Dhokale, R. A. "Development of novel methodologies in Aryne chemistry and their application in the total synthesis of bioactive natural products." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/4351.

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The present thesis demonstrates a creative exploration of aryne as versatile building blocks to construct new C–C and C–heteroatom bonds for the synthesis of various scaffolds and complex natural products. Chapter 1 describes a brief history of aryne, different methods available for their generation and various types of aryne reactions. Representative examples of insertion, pericyclic, annulation and multicomponent reactions of aryne are described in detail. Chapter 2 deals with our studies on C–C, C–P and C–N bond forming reactions of aryne, which is divided into three sections. Section 1 cov

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El, Marrouni El Ghazaoui Abdellatif. "Synthesis of unusual alpha-amino acids and study of the effect of their incorporation into antimicrobial peptides. Total synthesis of biactive marine natural products and analogues thereof." Doctoral thesis, Universitat de Girona, 2012. http://hdl.handle.net/10803/80815.

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The principle theme of this thesis was the synthesis of bioactive compounds. To this end, this work was focus on two main projects. The first one, which was carried out in the Department of Chemistry of the University of Girona under the supervision of Dr Montserrat Heras, concerned the synthesis of new unnatural amino acids bearing a pyrimidine ring within their side chain for incorporation into the antimicrobial peptide BP100 following a rational design in order to improve its biological profile. On the other hand, the second chapter of this thesis was developed in collaboration with the Lab

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Duplan, Vincent. "High-throughput synthesis of chemical libraries based on families of natural bioactive substances." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAF030.

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Les substances naturelles ont toujours joué un rôle important dans la recherche de nouvelles molécules d’intérêt thérapeutique. Ces produits peuvent être aussi utilisés comme sondes dans l’étude de systèmes biologiques et améliorer notre compréhension de ces phénomènes. Toutefois, la grande majorité des librairies de molécules synthétisées en chimie médicinale dans l’industrie pharmaceutique ou dans la recherche académique sont composées de molécules possédant des squelettes hétérocycliques qui couvrent une faible partie de l’espace des molécules pouvant être potentiellement découvertes (estim

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Schwartz, Eric Brandon. "The Synthesis and Optimization of Bioactive Natural Products as Anticancer and Antileishmanial Agents." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1436964192.

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