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Relevant bibliographies by topics / Natural course of epilepsy

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Academic literature on the topic 'Natural course of epilepsy'

Author: Grafiati

Published: 3 June 2025

Last updated: 20 July 2025

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Journal articles on the topic "Natural course of epilepsy"

1

Hernandez-Ronquillo, L., JF Tellez-Zenteno, S. Buckley, L. Ladino-Malagon, and W. Adam. "Understanding the natural history of adult temporal lobe epilepsy." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 42, S1 (2015): S26. http://dx.doi.org/10.1017/cjn.2015.127.

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Temporal lobe epilepsy (TLE) is the most common type of epilepsy in adults. The literature in this field supports the notion than many patients become candidates for surgery and little is known about the group of patients who do not require surgical treatment. This is a retrospective cohort study that included all patients with TLE assessed and followed by the Saskatchewan Epilepsy Program since 2007. Mild course was defined as patients not having seizures, using or not AEDs at last follow up. Severe course of TLE was considered in patients with continuous seizures and patients who had epilepsy surgery. Descriptive statistics were used. OR and CI were calculated. One hundred and fifty nine patients were included. Age of patients at last follow up was 46.04 + 14.4 (range 19-88) years. Mean follow up of patients was 43.46+ 22.6 (6 to 84) months. Fourth six patients (29%) were seizure-free with AEDS (mild course TLE) and 113 (61%) had severe course of TLE. Patients with mild course of TLE were older (p 0.002), with a late onset of epilepsy (p< 0.001) and their epilepsy evolution was shorter (p<0.001). Our study shows that not all the patients with TLE require surgery and that a fair percentage of patients can be controlled with medication.

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AlSemari, Abdulaziz, Salah Baz, Fahad Alrabiah, et al. "Natural course of epilepsy concomitant with CNS tuberculomas." Epilepsy Research 99, no. 1-2 (2012): 107–11. http://dx.doi.org/10.1016/j.eplepsyres.2011.10.032.

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Sillanpää, Matti. "Natural course of treated epilepsy and medico-social outcomes. Turku studies. Part II." Journal of Epileptology 24, no. 1 (2016): 25–39. http://dx.doi.org/10.1515/joepi-2016-0001.

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SummaryIntroduction. Population-based data on the prognosis of childhood-onset epilepsy were almost nonexistent in the 1960s. This prompted me to start an epidemiological prospective study on children with epilepsy.Aim. To study the medical and social outcome of children with epilepsy.Methods. The most important personal data on the natural course and outcome were reviewed and compared with the relevant data of other investigators.Results and discussion. The natural course of treated epilepsy is remitting, uninterrupted by relapse (in 48%); a remitting-relapsing course (interrupted by relapses, in terminal remission) (19%); worsening course (early or late remission followed by drug-resistant epilepsy) (14%); and never in ≥5-year remission (drug resistance) (19%) The medical and social outcomes based on my unique, five decades followed cohort show that most subjects are in 10-year remission without medications, which is the definition of resolved epilepsy. Normal or subnormal IQ, non-symptomatic etiology, and low seizure frequency both in the first year of AED treatment and prior to medication appear to be clinical predictors of cure in childhood-onset epilepsy. Subjects with 1-year remission during the first five years form onset of treatment have more than 10-fold chance for entering 5-year terminal remission vs those who have no 1-year remission during the first five years. Even about one fourth of difficult-to-treat subjects become seizure free on medication and more than half of them enter one or more 5-year remissions. Epilepsy has a substantial impact on quality of life even in those who are seizure free off medication for many years and particularly those not in remission or in remission but still on medication.Conclusions. The prognosis is excellent for medical and social outcome. The successful outcome is confirmed by several longitudinal studies from recent decades. Good response to early drug therapy does not necessarily guarantee a favorable seizure outcome, and even a late good response may still predict a successful prognosis. Our life-cycle study is being continued and targets to answer the question whether or not childhood-onset epilepsy is a risk factor for premature and/or increased incidence of mental impairment and dementia.

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Balagura, Ganna, Julie Xian, Antonella Riva, et al. "Epilepsy Course and Developmental Trajectories in STXBP1-DEE." Neurology Genetics 8, no. 3 (2022): e676. http://dx.doi.org/10.1212/nxg.0000000000000676.

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Background and ObjectivesClinical manifestations in STXBP1 developmental and epileptic encephalopathy (DEE) vary in severity and outcome, and the genotypic spectrum is diverse. We aim to trace the neurodevelopmental trajectories in individuals with STXBP1-DEE and dissect the relationship between neurodevelopment and epilepsy.MethodsRetrospective standardized clinical data were collected through international collaboration. A composite neurodevelopmental score system compared the developmental trajectories in STXBP1-DEE.ResultsForty-eight patients with de novo STXBP1 variants and a history of epilepsy were included (age range at the time of the study: 10 months to 35 years, mean 8.5 years). At the time of inclusion, 65% of individuals (31/48) had active epilepsy, whereas 35% (17/48) were seizure free, and 76% of those (13/17) achieved remission within the first year of life. Twenty-two individuals (46%) showed signs of developmental impairment and/or neurologic abnormalities before epilepsy onset. Age at seizure onset correlated with severity of developmental outcome and the developmental milestones achieved, with a later seizure onset associated with better developmental outcome. In contrast, age at seizure remission and epilepsy duration did not affect neurodevelopmental outcomes. Overall, we did not observe a clear genotype-phenotype correlation, but monozygotic twins with de novo STXBP1 variant showed similar phenotype and parallel disease course.DiscussionThe disease course in STXBP1-DEE presents with 2 main trajectories, with either early seizure remission or drug-resistant epilepsy, and a range of neurodevelopmental outcomes from mild to profound intellectual disability. Age at seizure onset is the only epilepsy-related feature associated with neurodevelopment outcome. These findings can inform future dedicated natural history studies and trial design.

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Tasic, G. M., A. Kostic, B. M. Djurovic, et al. "Natural course of the arteriovenous malformations of the brain." Acta chirurgica Iugoslavica 55, no. 2 (2008): 107–18. http://dx.doi.org/10.2298/aci0802107t.

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Arteriovenous cerebral malformations represent congenital malformations. Considering the anatomical characteristics of the cerebral angiomas and their localization, in a great number of cases they demand a combined therapeutic approach - surgery,. embolization and radiotherapy. Besides the constant progress of technology, 5% of all cerebral angiomas can not be completely excluded from the circulation. Therefore, the need to understand their natural course became a necessity. Our results point to the fact that they are vascular malformations of a considerably more benign clinical course than the aneurysms. Our clinical model points to an annual risk of hemorrhage which is 3.3% with total mortality of 5.3%, especially if the size of the angioma is 2.5-5 cm, localized in the motor zone of the brain, with combined type of vein drainage and arterial supply from the vertebrobasilary confluence. Epilepsy caused by the cerebral angioma is in 26.7% refractory to medicamentous therapy and in 25% (every 4th patient) will have hemorrhage with an annual risk of 0.14%.

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Leoncini, Silvia, Lidia Boasiako, Diego Lopergolo, et al. "Natural Course of IQSEC2-Related Encephalopathy: An Italian National Structured Survey." Children 10, no. 9 (2023): 1442. http://dx.doi.org/10.3390/children10091442.

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Pathogenic loss-of-function variants in the IQ motif and SEC7 domain containing protein 2 (IQSEC2) gene cause intellectual disability with Rett syndrome (RTT)-like features. The aim of this study was to obtain systematic information on the natural history and extra-central nervous system (CNS) manifestations for the Italian IQSEC2 population (>90%) by using structured family interviews and semi-quantitative questionnaires. IQSEC2 encephalopathy prevalence estimate was 7.0 to 7.9 × 10−7. Criteria for typical RTT were met in 42.1% of the cases, although psychomotor regression was occasionally evidenced. Genetic diagnosis was occasionally achieved in infancy despite a clinical onset before the first 24 months of life. High severity in both the CNS and extra-CNS manifestations for the IQSEC2 patients was documented and related to a consistently adverse quality of life. Neurodevelopmental delay was diagnosed before the onset of epilepsy by 1.8 to 2.4 years. An earlier age at menarche in IQSEC2 female patients was reported. Sleep disturbance was highly prevalent (60 to 77.8%), with mandatory co-sleeping behavior (50% of the female patients) being related to de novo variant origin, younger age, taller height with underweight, better social interaction, and lower life quality impact for the family and friends area. In conclusion, the IQSEC2 encephalopathy is a rare and likely underdiagnosed developmental encephalopathy leading to an adverse life quality impact.

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Zahn, Carole Anouk, and Peter Itin. "Papular Epidermal Nevus with “Skyline” Basal Cell Layer Syndrome – Natural Course: Case Report and Literature Review." Case Reports in Dermatology 9, no. 1 (2017): 1–5. http://dx.doi.org/10.1159/000454757.

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Papular epidermal nevus with “skyline” basal cell layer (PENS) is a very rare type of keratinocytic nevus and is associated with extracutaneous findings such as neurological symptoms in about 50% of the cases. Therefore, it is also referred to as PENS syndrome. Clinically visible hyperkeratotic papules and plaques already appear at birth or shortly thereafter, while neurological symptoms such as epilepsy and mental retardation manifest themselves during childhood. Genetics suggests gonadal mosaicism as a possible cause for the disease. Another hypothesis is that genetic mutation can occur in a mendelian trait or through a paradominant inheritance.

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Berg, Anne T. "Understanding the Delay Before Epilepsy Surgery: Who Develops Intractable Focal Epilepsy and When?" CNS Spectrums 9, no. 2 (2004): 136–44. http://dx.doi.org/10.1017/s109285290000849x.

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AbstractIntractable temporal lobe epilepsy that is surgically treated in adulthood is a disorder whose onset frequently occurs during childhood and early adolescence. The average duration of epilepsy prior to surgery is on the order of 20 years. The long delay between onset and surgery has at least two components: time from onset to intractability and time from evidence of intractability to surgery. The first interval is prolonged >10 years especially if the onset is during childhood. This suggests a complex natural history that we have not fully appreciated as well as a potential window of opportunity for early secondary intervention. The second interval is also prolonged, especially if onset was during childhood. Reasons for this are not fully clear but may include a reluctance to consider surgery and perhaps difficulty deciding whether seizures are sufficiently intractable to warrant surgery especially after what may have been a relatively benign initial course. Factors involved in the second delay need to be better understood so that surgical interventions can be appropriately targeted early rather than late, thereby reducing serious social, psychological, and educational consequences associated with uncontrolled seizures.

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von Podewils, Felix, Sabine Lapp, Z. Irene Wang, et al. "Natural course and predictors of spontaneous seizure remission in idiopathic generalized epilepsy: 7–27 years of follow-up." Epilepsy Research 108, no. 7 (2014): 1221–27. http://dx.doi.org/10.1016/j.eplepsyres.2014.04.004.

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Osipova, Liliya A., Ludmila M. Kuzenkova, and Tatyana V. Podkletnova. "Natural history of neuronopathic form of Hunter syndrome in children: observational cohort study." L.O. Badalyan Neurological Journal 4, no. 2 (2023): 74–83. http://dx.doi.org/10.46563/2686-8997-2023-4-2-74-83.

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Introduction. Mucopolysaccharidosis type II (MPS II, Hunter syndrome) (mucopolysaccharidosis type II, MPS II) is a progressive multisystem disorder. Neurodegenerative course characterizes the severe (neuronopathic) form of MPS II. Pathogenetic therapy for the severe form of the disease is under development, and symptomatic neurological treatment is to be improved. Natural history data are required for rationalization of symptomatic care and assessment of emergent treatment effectiveness. The aim of the study. To describe the course of neurodegenerative disease in children with neuronopathic form of MPS II.  Materials and methods. Fifty eight boys with established diagnosis of MPS II were included in the study. The course of the disease in 42 patients was classified as neuronopathic. Data on complaints, anamnesis and neurological examination obtained from medical documentation and within the framework of this study, as well as descriptions of video-EEG monitorings, performed in National Medical Research Center of Children’s Health, were used. Results. The spectrum and chronology of neurological symptoms in children with severe Hunter syndrome were described. 64% of patients were found to achieve the level of phrasal speech at any time of the development. Laughter or crying paroxysms in children with neuronopathiс MPS II were judged to be a manifestation of pseudobulbar affect. Burden of sleep disorder was demonstrated to increase through the course of the disease. Absence of epileptic seizure was significantly more frequent than epilepsy manifestation during the first two years after epiactivity appears on EEG (75 vs 25%; p = 0.046). Conclusion. Obtained natural history descriptions of severe MPS II cases are intended to be used in optimization of neurological care for patients and in assessment of emergent treatments’ effectiveness in real clinical practice.

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Dissertations / Theses on the topic "Natural course of epilepsy"

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Kwan, Patrick Kwok Leung. "Refractory epilepsy : natural history and pathogenesis." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250783.

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Wittchen, Hans-Ulrich, Stephan Mühlig, and Lukas Pezawas. "Natural course and burden of bipolar disorders." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-117282.

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Despite an abundance of older and more recent retrospective and considerably fewer prospective-longitudinal studies in bipolar disorders I and II, there are still remarkable deficits with regard to our knowledge about the natural course and burden. The considerable general and diagnosis-specific challenges posed by the nature of bipolar disorders are specified, highlighting in particular problems in diagnostic and symptom assessment, shifts in diagnostic conventions and the broadening of the diagnostic concept by including bipolar spectrum disorders. As a consequence it still remains difficult to agree on several core features of bipolar disorders, such as when they begin, how many remit spontaneously and how many take a chronic course. On the basis of clinical and epidemiological findings this paper summarizes (i) a significant need to extend the study of the natural course of bipolar disorder in clinical samples beyond the snapshot of acute episodes to the study of the mid-term and long-term symptom course, associated comorbidities and the associated burden of the disease. (ii) In terms of epidemiological studies, that are also of key importance for resolving the critical issues of threshold definitions in the context of the bipolar spectrum concept, there is a clear need for identifying the most relevant risk factors for the first onset and those for the further illness progression in early stages. Since there are some indications that these critical processes might start as early as adolescence, such studies might concentrate on young cohorts and clearly before these prospective patients come to clinical attention. (iii) The value of both types of studies might be enhanced, if beyond the use of standardized diagnostic interview, special attempts are made to use prospective life- and episode-charting methods for bipolar illnesses.

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Wittchen, Hans-Ulrich, Stephan Mühlig, and Lukas Pezawas. "Natural course and burden of bipolar disorders." Technische Universität Dresden, 2003. https://tud.qucosa.de/id/qucosa%3A27010.

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Despite an abundance of older and more recent retrospective and considerably fewer prospective-longitudinal studies in bipolar disorders I and II, there are still remarkable deficits with regard to our knowledge about the natural course and burden. The considerable general and diagnosis-specific challenges posed by the nature of bipolar disorders are specified, highlighting in particular problems in diagnostic and symptom assessment, shifts in diagnostic conventions and the broadening of the diagnostic concept by including bipolar spectrum disorders. As a consequence it still remains difficult to agree on several core features of bipolar disorders, such as when they begin, how many remit spontaneously and how many take a chronic course. On the basis of clinical and epidemiological findings this paper summarizes (i) a significant need to extend the study of the natural course of bipolar disorder in clinical samples beyond the snapshot of acute episodes to the study of the mid-term and long-term symptom course, associated comorbidities and the associated burden of the disease. (ii) In terms of epidemiological studies, that are also of key importance for resolving the critical issues of threshold definitions in the context of the bipolar spectrum concept, there is a clear need for identifying the most relevant risk factors for the first onset and those for the further illness progression in early stages. Since there are some indications that these critical processes might start as early as adolescence, such studies might concentrate on young cohorts and clearly before these prospective patients come to clinical attention. (iii) The value of both types of studies might be enhanced, if beyond the use of standardized diagnostic interview, special attempts are made to use prospective life- and episode-charting methods for bipolar illnesses.

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Roane, Brandy Michelle. "Natural Course of Adolescent Insomnia: Patterns and Consequences." Thesis, University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc30506/.

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Approximately 2-11% of adolescents report chronic insomnia. The study used an archival data set from ADDHealth that assessed adolescent health and health-related behaviors. Adolescents (N = 4102) provided data at baseline (Time 1) and at 1-year follow-up (Time 2). Participants were excluded if no ethnicity, gender, or insomnia data were given at Time 1 or 2. Females were more likely to report insomnia than males at Times 1 and 2. In addition, adolescents with remitted insomnia were significantly younger than adolescents without insomnia at Times 1 and 2. Analyses found a prevalence of 9.6%, a remittance of 6.2%, an incidence of 4.4%, and a chronicity of 2.9%. At Time 1 and 2, AWI were significantly more likely to have depression, suicidal behaviors, and behavioral problems in school than AWOI. At Time 2, incidence and chronic insomnia increased the risk of depression, suicidal behaviors and behavioral problems in school. Risk and protective factors analyses indicated psychological counseling was associated with both remitted and chronic insomnia and depression was associated with incidence insomnia.

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Taylor, Joanne. "The natural history of cognitive functioning in people with newly diagnosed epilepsy." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533926.

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Paterson, Kevin Brisbane. "The time course of processing of natural language quantification." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320843.

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Bechtol, Vanessa Lee. "Sustainable Flood Mitigation: Returning Rivers to Their Natural Course." Thesis, The University of Arizona, 2003. http://hdl.handle.net/10150/190238.

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Community participation in flood planning has recently emerged as a successful approach to addressing and restricting the traditionally structural methods of flood control. Flooding, the most costly natural hazard worldwide, causes economic damages in spite of flood control efforts throughout the 20th century. To control flooding while allowing development, localities have traditionally used structural controls, such as levees and floodwalls, to physically separate floods from people. In light of the continued failure, high costs, and environmental degradation associated with structural flood controls, localities are now increasingly focusing on non-structural flood mitigation methods to reduce flood risks and losses. Furthermore, communities throughout the country are incorporating innovative flood projects that balance structural and non-structural flood mitigation in an attempt to better address environmental concerns. This approach involves returning previously damaged rivers and floodplains to their natural state. This evolution from structural approaches to environmentally conscious flood planning is illustrated through a case study of Napa, California’s model flood plan. Through an analysis of the flood plan and interviews with government representatives and project engineers, this case study illustrates how localities can design and implement flood plans to provide for environmentally sustainable flood mitigation. Building on a model of best management practices which incorporates the “living river” concept in the Napa River Flood Protection Project, this report suggests how other communities with severe river flooding can develop similar sustainable flood plans. Napa’s flood project represents a paradigm shift in which local residents were the driving force behind designing an environmentally sustainable and locally supported flood plan that would be carried out by the U.S. Army Corps of Engineers. The key lessons learned from Napa’s flood project are that community involvement and consensus building among stakeholders are crucial to developing and implementing an environmentally sustainable flood management project.

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Beesdo-Baum, Katja, Susanne Knappe, Lydia Fehm, et al. "The Natural Course of Social Anxiety Disorder among Adolescents and Young Adults." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-117728.

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Objective. To examine the natural course of social anxiety disorder (SAD) in the community and to explore predictors for adverse long-term outcomes. Method. A community sample of N=3,021 subjects aged 14-24 was followed-up over 10 years using the DSM-IV/M-CIDI. Persistence of SAD is based on a composite score reflecting the proportion of years affected since onset. Diagnostic stability is the proportion of SAD subjects still affected at follow-up. Results. SAD reveals considerable persistence with more than half of the years observed since onset spent with symptoms. 56.7% of SAD cases revealed stability with at least symptomatic expressions at follow-up; 15.5% met SAD threshold criteria again. 15.1% were completely remitted (no SAD symptoms and no other mental disorders during follow-up). Several clinical features (early onset, generalized subtype, more anxiety cognitions, severe avoidance and impairment, co-occurring panic) and vulnerability characteristics (parental SAD and depression, behavioural inhibition, harm avoidance) predicted higher SAD persistence and -less impressively- diagnostic stability. Conclusion. A persistent course with a considerable degree of fluctuations in symptom severity is characteristic for SAD. Both, consistently meeting full threshold diagnostic criteria and complete remissions are rare. Vulnerability and clinical severity indicators predict poor prognosis and might be helpful markers for intervention needs.

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Beesdo-Baum, Katja, Susanne Knappe, Lydia Fehm, et al. "The Natural Course of Social Anxiety Disorder among Adolescents and Young Adults." Technische Universität Dresden, 2012. https://tud.qucosa.de/id/qucosa%3A27045.

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Objective. To examine the natural course of social anxiety disorder (SAD) in the community and to explore predictors for adverse long-term outcomes. Method. A community sample of N=3,021 subjects aged 14-24 was followed-up over 10 years using the DSM-IV/M-CIDI. Persistence of SAD is based on a composite score reflecting the proportion of years affected since onset. Diagnostic stability is the proportion of SAD subjects still affected at follow-up. Results. SAD reveals considerable persistence with more than half of the years observed since onset spent with symptoms. 56.7% of SAD cases revealed stability with at least symptomatic expressions at follow-up; 15.5% met SAD threshold criteria again. 15.1% were completely remitted (no SAD symptoms and no other mental disorders during follow-up). Several clinical features (early onset, generalized subtype, more anxiety cognitions, severe avoidance and impairment, co-occurring panic) and vulnerability characteristics (parental SAD and depression, behavioural inhibition, harm avoidance) predicted higher SAD persistence and -less impressively- diagnostic stability. Conclusion. A persistent course with a considerable degree of fluctuations in symptom severity is characteristic for SAD. Both, consistently meeting full threshold diagnostic criteria and complete remissions are rare. Vulnerability and clinical severity indicators predict poor prognosis and might be helpful markers for intervention needs.

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Saarela, T. (Timo). "Nephrocalcinosis in infants:incidence, risk factors, natural course and renal outcome in certain risk groups." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:951425404X.

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Abstract The aim of the present work was to elucidate the incidence, associated risk factors and natural course of nephrocalcinosis (NC) in very low birth weight (VLBW) infants, and to evaluate renal function in affected infants during early childhood. The occurrence and course of NC in full-term infants receiving furosemide and in infants with congenital lactase deficiency were also studied. A total of 129 VLBW infants were screened for NC by renal ultrasonography (US) at 2 and 6 weeks and 3 months, and ultrasonic follow-up was performed on the infants with NC at 6, 12, 18 and 24 months, and thereafter annually up to age 5-6 years or until ultrasonic resolution. NC was classified according to its pyramidal localisation and extent. Twenty VLBW children with neonatal NC and 20 control pairs without the condition were examined for renal function at 4.7 (SD 1.1) vs. 4.6 (0.9) years of age. Thirty-six full-term infants who had received furosemide treatment for congestive heart failure for at least 4 weeks and 36 control infants without any diuretic therapy were examined by renal US and by means of a random urine sample taken at a median age of 2.9 vs. 3.4 months. The case records of the 11 infants with congenital lactase deficiency were analysed for NC, and these children were re-evaluated at 2 to 10 years of age. NC was detected in 26 out of the 129 VLBW infants (20%). The infants with NC were sicker and smaller than the unaffected ones and had more often received furosemide, dexamethasone and theophylline treatment. NC was peripheral in 14 cases (54%), scattered in 7 (27%) and extensive in 5 (19%). All the casesof peripheral NC showed resolution at 12 months, but abnormal renal findings were seen in 3 out of the 7 with scattered NC and 3 out of the 4 surviving children with extensive NC at 24 months, in 2 of whom the condition persisted at age 5-6 years. The children with neonatal NC showed increased urinary calcium and μ2-microglobulin excretion as compared with the controls in early childhood, but there was no significant difference in distal tubular acidification capacity, nor in estimated creatinine clearance. Five out of the 36 full-term infants receiving long-term furosemide had NC, but none of the controls. The daily dose of furosemide and the urinary calcium concentration were both higher in the infants with NC. Abnormal renal findings were still visible in two of the cases at 24 months of age. Hypercalcaemia was found in 7 out of 10 infants with congenital lactase deficiency tested at the time of diagnosis, and NC was seen in 5 of the 7 cases examined by renal ultrasonography. No constant dysfunction in calcium homeostasis was seen at re-evaluation, but nephrocalcinotic changes were observable in 3 out of the 11 children. NC may complicate not only the course of VLBW infants, but also that of full-term infants with calciuric medication and diseases that involve hypercalcaemia. Some renal tubular dysfunction may result from NC in former preterm infants, but overall kidney function seems not to be seriously compromised in early childhood.

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Books on the topic "Natural course of epilepsy"

1

Branch, Alberta Curriculum. Natural resource studies: Course of studies. --. Alberta Education, Curriculum Branch, 1993.

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Haralambous, Yannis. A Course in Natural Language Processing. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-27226-4.

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L, Weaire D., Kelly P, and Attis D. A, eds. A course of lectures in natural philosophy. 4th ed. Physics Department of Trinity College, 1999.

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Ian, Dair, Schofield Mike, and Nature Conservancy Council, eds. On course conservation: Managing golf's natural heritage. Nature Conservancy Council Publicity Services Branch, 1989.

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V, Horie C., Murphy R. G, Manchester Museum (University of Manchester), and University of Manchester. Department of Environmental Biology., eds. Conservation of natural history specimens [course proceedings]. Manchester Museum and Department of Environmental Biology, University of Manchester, 1988.

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Weiner, Lawrence. A natural water course diverted reduced or displaced. Lowe, 2001.

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Dellar, Hugh. Innovations: A course in natural English : elementary : workbook. Thompson, 2006.

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Fernando, Emmanuel Q. A course in legal theory. Published & distributed by Rex Book Store, 2011.

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Steiner, Rudolf. The light course: First course in natural science : light, color, sound--mass, electricity, magnetism. Anthroposophic Press, 2001.

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Nelson, John. Collision course: Asteroids and Earth. Rosen Pub. Group, 2009.

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Book chapters on the topic "Natural course of epilepsy"

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Girvin, John P. "Postoperative Course." In Operative Techniques in Epilepsy. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10921-3_13.

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Focke, Christfried H., and Rob M. Sylvester. "Natural Language Processing." In Statistical Methods in Epilepsy. Chapman and Hall/CRC, 2024. http://dx.doi.org/10.1201/9781003254515-13.

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Hosseinzadeh, Hossein, and Marjan Nassiri-Asl. "Neuroprotective Effects of Flavonoids in Epilepsy." In Neuroprotective Natural Products. Wiley-VCH Verlag GmbH & Co. KGaA, 2017. http://dx.doi.org/10.1002/9783527803781.ch10.

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Arenillas, Juan F., Louis R. Caplan, and K. S. Lawrence Wong. "Natural Course and Prognosis." In Intracranial Atherosclerosis. Wiley-Blackwell, 2009. http://dx.doi.org/10.1002/9781444300673.ch9.

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Beesdo-Baum, Katja, and Susanne Knappe. "Epidemiology and Natural Course." In The Wiley Handbook of Anxiety Disorders. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118775349.ch3.

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Kumar Rath, Santosh, Gursharan Kaur, Palak Rana, Mittali Goyal, Vagish Dwibedi, and Ranjana Prakash. "Natural Bioactive used as Epilepsy Activity." In Natural Scaffolds for Prevention and Treatment of Neurodegenerative Disorders. CRC Press, 2025. https://doi.org/10.1201/9781003403241-4.

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Haralambous, Yannis. "Controlled Natural Languages." In A Course in Natural Language Processing. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-27226-4_7.

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Valencia, Maria, and Emilio Calvo. "Natural Course of Frozen Shoulder." In Shoulder Stiffness. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46370-3_15.

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Lankisch, Paul Georg. "Natural Course of Chronic Pancreatitis." In Pancreatic Disease. Springer London, 2004. http://dx.doi.org/10.1007/978-1-85233-904-3_15.

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Harders, Albrecht G. "Natural Time Course of Vasospasm." In Neurosurgical Applications of Transcranial Doppler Sonography. Springer Vienna, 1986. http://dx.doi.org/10.1007/978-3-7091-8868-2_9.

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Conference papers on the topic "Natural course of epilepsy"

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Holgate, Ben, Shichao Fang, Anthony Shek, et al. "Extracting Epilepsy Patient Data with Llama 2." In Proceedings of the 23rd Workshop on Biomedical Natural Language Processing. Association for Computational Linguistics, 2024. http://dx.doi.org/10.18653/v1/2024.bionlp-1.43.

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Parde, Natalie. "Example-Driven Course Slides on Natural Language Processing Concepts." In Proceedings of the Sixth Workshop on Teaching NLP. Association for Computational Linguistics, 2024. http://dx.doi.org/10.18653/v1/2024.teachingnlp-1.2.

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Leeshma, K., and M. Praveena. "Natural Language Processing and Machine Learning Based Automated Diagnosis of Epilepsy in Electronic Health Record." In 2024 International Conference on Computing, Sciences and Communications (ICCSC). IEEE, 2024. https://doi.org/10.1109/iccsc62048.2024.10830353.

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Xu, Rongwu, Yishuo Cai, Zhenhong Zhou, et al. "Course-Correction: Safety Alignment Using Synthetic Preferences." In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing: Industry Track. Association for Computational Linguistics, 2024. http://dx.doi.org/10.18653/v1/2024.emnlp-industry.119.

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Deepanchakkaravarthy, K., and S. Umarani. "Enhancing Educational Outcomes Through Natural Language Processing Using Sentiment Analysis to Understand Course Feedback." In 2024 13th International Conference on System Modeling & Advancement in Research Trends (SMART). IEEE, 2024. https://doi.org/10.1109/smart63812.2024.10882554.

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Chiang, Cheng-Han, Wei-Chih Chen, Chun-Yi Kuan, Chienchou Yang, and Hung-yi Lee. "Large Language Model as an Assignment Evaluator: Insights, Feedback, and Challenges in a 1000+ Student Course." In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing. Association for Computational Linguistics, 2024. http://dx.doi.org/10.18653/v1/2024.emnlp-main.146.

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Tian, Xin, Qiang Guo, Yijun Song, and Wenwen Bai. "Entropy Coding of Neural Firing at Hippocampus for Temporal Lobe Epilepsy Rats." In 2008 Fourth International Conference on Natural Computation. IEEE, 2008. http://dx.doi.org/10.1109/icnc.2008.442.

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Song, Jin Woo, Woo Sung Kim, Eun Jin Chae, et al. "The Natural Course Of Idiopathic Pulmonary Fibrosis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2959.

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Kuznecov, S., and V. Nebol'sina. "GREEN ECONOMY AS A NEW COURSE OF MOVEMENT." In GREEN ECONOMY: IFOREST. FSBE Institution of Higher Education Voronezh State University of Forestry and Technologies named after G.F. Morozov, 2022. http://dx.doi.org/10.34220/zeif2022_48-51.

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The green economy is an interpretation of the concept of sustainable development, which combines the issues of economic, social and environmental development. We are talking about creating an economic system structured taking into account environmental and social factors. This should reduce the burden on the environment, help preserve and restore natural ecosystems and increase natural capital. Also, the measures of the "green" economy imply reducing inequality, improving the quality of life, working conditions and accessibility of social services.

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Mansour, Nashat, and Hanaa El-Jazzar. "Curriculum based course timetabling." In 2013 9th International Conference on Natural Computation (ICNC). IEEE, 2013. http://dx.doi.org/10.1109/icnc.2013.6818082.

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Reports on the topic "Natural course of epilepsy"

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Wright, Sarah, and Camille Andrews. Developing a For-Credit Course to Teach Data Information Literacy Skills: A Case Study in Natural Resources. Purdue University, 2015. http://dx.doi.org/10.5703/1288284315476.

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Sokolyuk, O. M., N. P. Dement, O. P. Pinchuk, and O. V. Slobodyanyk. Features of the use of computer simulations in the school physics course. NAES of Ukraine, 2019. http://dx.doi.org/10.33407/lib.naes.717235.

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The article is devoted to the problem of increasing the methodological level of teaching subjects of the natural mathematical cycle, in particular physics, in institutions of general secondary education. It is noted that the formation of basic competencies in the natural sciences and technologies is possible through the active use of computer-oriented technical means in the educational process. Working with computer models in physics lessons creates the conditions for the realization of cognitive activity of students, positively affects the formation of both the motivational and the substantive-process component of the subject competence of students.

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Levochkina, N. A. Lecture course for distance learning "Museum management" (training course: 43.03.02 "Tourism", 51.03.04 "Museology and protection of objects of cultural and natural heritage", level of higher education - bachelor's degree). Science and Innovation Center Publishing House, 2016. http://dx.doi.org/10.12731/levochkina.01112016.22234.

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Greenfeld, Bari, Margaret Kurth, Matthew Smith, Ellis Kalaidjian, Marriah Abellera, and Jeffrey King. Financing natural infrastructure : Exploration Green, Texas. Engineer Research and Development Center (U.S.), 2022. http://dx.doi.org/10.21079/11681/45601.

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This technical note is part of a series collaboratively produced by the US Army Corps of Engineers (USACE)–Institute for Water Resources (IWR) and the US Army Engineer Research and Development Center (ERDC). It describes the funding process for Exploration Green, a largescale community initiative that transformed a former golf course into a multipurpose green space with flood detention, habitat, and recreation benefits. It is one in a series of technical notes that document successful examples of funding natural infrastructure projects. The research effort is a collaboration between the Engineering With Nature® (EWN®) and Systems Approach to Geomorphic Engineering (SAGE) programs of USACE. A key need for greater application of natural infrastructure approaches is information about obtaining funds to scope, design, construct, monitor, and adaptively manage these projects. As natural infrastructure techniques vary widely by location, purpose, and scale, there is no standard process for securing funds. The goal of this series is to share lessons learned about a variety of funding and financing methods to increase the implementation of natural infrastructure projects.

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Lindo-Ocampo, Gloria Inés, and Hilda Clarena Buitrago-García. English for Business Course. Thematic Unit: Business Events. Ediciones Universidad Cooperativa de Colombia, 2022. http://dx.doi.org/10.16925/gcnc.24.

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This didactic unit is aimed at the fifth semester students of the Business Administration, Marketing and International Business program, who have already completed the four basic levels of the Open Lingua program. This proposal seeks to develop skills and competencies that allow them to perform in different fields related to private, public and solidarity economy companies, and in various mediation and negotiation processes at national and international levels. The instructional design of this unit contains real-life situations, focused on the world of business, that allow students to interact in various types of business events. The grammatical and lexical concepts, necessary to interact successfully in these types of communicative situations, are introduced and applied. The educational activities are designed to offer opportunities to interact in business conferences, international exhibitions, and seminars, among others. The contents are framed in natural and meaningful contexts. This leads to a greater understanding of the type of language used in business and the way it is used to communicate. The contents are structured in three lessons in which the level of complexity of the topics, tasks, texts and transitions (4Ts) have been considered. Also, various types of activities that activate and reinforce previous knowledge and that, subsequently, evaluate the progress of the students, are included.

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Badiale, Cecilia Sofia, Therese Forsgren Mahoney, Eva-Peter Dunkel-Dürr, et al. Reconnecting to the natural world -Through animals and nature-based activities. Faculty of Landscape Architecture, Horticulture and Crop Production Science, Swedish University of Agricultural Sciences, 2024. http://dx.doi.org/10.54612/a.6fq8e9vvp0.

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The international master’s program, Outdoor Environments for Health and Well-Being, leads to a Master of Science degree specializing in environmental psychology. The program covers health-promoting outdoor environments throughout the lifespan, evidence-based health design, occupational aspects, and the One Health concept. One of the courses offered is Nature and Animal-Assisted Interventions (MP0009), which focuses on occupations, occupational performance, and values performed with natural elements and/or animals in indoor or outdoor settings, i.e., a place independent occupational performance for health promotion. This fact sheet is a final assignment of the student´s work, presented at the NAAI course conference in 2024.

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Pan, Xiaoyang. How the Natural Environment of the Golf Course Affects Mental Fatigue in Golfers: Healing or Hindrance? A Systematic Review and Conceptual Model. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2025. https://doi.org/10.37766/inplasy2025.1.0019.

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Apelqvist, Matilda, Amanda Sandsborg, Marc Schildt, et al. Going outside to reach inside : nature and animal-assisted interventions (NAAI) - A bridge to our embodied experiences. Faculty of Landscape Architecture, Horticulture and Crop Production Science, Swedish University of Agricultural Sciences, 2024. http://dx.doi.org/10.54612/a.6k8t1ao59p.

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The international master program Outdoor Environments for Health and Well-Being leads to a Master of Science degree specializing in Environmental psychology. The program covers topics on health-promoting outdoor environments throughout the lifespan, evidence-based health design, occupational aspects and the One Health concept. One of the courses offered is Nature and Animal-Assisted Interventions (MP0009), which focuses on occupations, occupational performance and values performed with natural elements and/or animals in indoor or outdoor settings, i.e. a place independent occupational performances for health promotion. The abstract and the poster in this fact sheet were presented at the course conference, the final moment at the NAAI course spring 2024.

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Jones, David, Roy Cook, John Sovell, et al. Natural resource condition assessment: Lincoln Boyhood National Memorial. National Park Service, 2024. http://dx.doi.org/10.36967/2301822.

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The National Park Service (NPS) Natural Resource Condition Assessment (NRCA) Program administered by the NPS Water Resources Division evaluates current conditions for important natural resources and resource indicators using primarily existing information and data. NRCAs also report on trends in resource condition, when possible, identify critical data gaps, and characterize a general level of confidence for study findings. This NRCA complements previous scientific endeavors, is multi-disciplinary in scope, employs a hierarchical indicator framework, identifies and develops reference conditions/values for comparison against current conditions, and emphasizes spatial evaluation of conditions where possible. Lincoln Boyhood National Memorial (LIBO) was authorized by an act of Congress on February 19, 1962, (Public Law 87-407) to preserve the site associated with the boyhood and family of President Abraham Lincoln, including a portion of the original Tom Lincoln farm and the nearby gravesite of Nancy Hanks Lincoln. The 200-acre memorial commemorates the pioneer farm where Abraham Lincoln lived from the age of 7 to 21. The NRCA for LIBO employed a scoping process involving Colorado State University, LIBO and other NPS staffs to establish the NRCA framework, identify important park resources, and gather existing information and data. Indicators and measures for each resource were then identified and evaluated. Data and information were analyzed and synthesized to provide summaries and address condition, trend and confidence using a standardized but flexible framework. A total of nine focal resources were examined: four addressing system and human dimensions, one addressing chemical and physical attributes, and four addressing biological attributes. The quality and currentness of data used for the evaluation varied by resource. Landscape context ? system and human dimensions included land cover and land use, natural night skies, soundscape, and climate change. Climate change and land cover/land use were not assigned a condition or trend?they provide important context to the memorial and many natural resources and can be stressors. Some of the land cover and land use-related stressors at LIBO and in the larger region are related to the development of rural land and increases in population/housing over time. The trend in land development, coupled with the lack of significantly sized and linked protected areas, presents significant challenges to the conservation of natural resources of LIBO to also include natural night skies, natural sounds and scenery. Climate change is happening and is affecting resources, but is not considered good or bad per se. The information synthesized in that section is useful in examining potential trends in the vulnerability of sensitive resources and broad habitat types such as forests. Night skies and soundscapes, significantly altered by disturbance due to traffic, development and urbanization, warrant significant and moderate concern, respectively, and appear to be in decline. Air quality was the sole resource supporting chemical and physical environment at the memorial. The condition of air quality can affect human dimensions of the park such as visibility and scenery as well as biological components such as the effect of ozone levels on vegetation health. Air quality warrants significant concern and is largely impacted by historical and current land uses outside the memorial boundary. The floral biological component was examined by assessing native species composition, Mean Coefficient of Conservation, Floristic Quality Assessment Index, invasive exotic plants, forest pests and disease, and forest vulnerability to climate change. Vegetation resources at LIBO have been influenced by historical land uses that have changed the species composition and age structure of these communities. Although large tracts of forests can be found surrounding the park, the majority of forested areas are fragmented, and few areas within and around LIBO exhibit late-successional or old-growth characteristics. Vegetation communities at LIBO have a long history of being impacted by a variety of stressors and threats including noxious and invasive weeds, diseases and insect pests; compounding effects of climate change, air pollution, acid rain/atmospheric chemistry, and past land uses; and impacts associated with overabundant white-tail deer populations. These stressors and threats have collectively shaped and continue to impact plant community condition and ecological succession. The sole metric in good condition was native species composition, while all other indicators and metrics warranted either moderate or significant concern. The faunal biological components examined included birds, herptiles, and mammals. Birds (unchanging trend) and herptiles (no trend determined) warrant moderate concern, while mammal populations warrant significant concern (no trend determined). The confidence of both herptiles and mammals was low due to length of time since data were last collected. Current forest structure within and surrounding LIBO generally reflects the historical overstory composition but changes in the hardwood forest at LIBO and the surrounding area have resulted in declines in the avian fauna of the region since the 1970s. The decline in woodland bird populations has been caused by multiple factors including the conversion of hardwood forest to other land cover types, habitat fragmentation, and increasing human population growth. The identification of data gaps during the course of the assessment is an important NRCA outcome. Resource-specific details are presented in each resource section. In some cases, significant data gaps contributed to the resource not being evaluated or low confidence in the condition or trend being assigned to a resource. Primary data gaps and uncertainties encountered were lack of recent survey data, uncertainties regarding reference conditions, availability of consistent long-term data, and the need for more robust or sensitive sampling designs. Impacts associated with development outside the park will continue to stress some resources. Regionally, the direct and indirect effects of climate change are likely but specific outcomes are uncertain. Nonetheless, within the past several decades, some progress has been made toward restoring the quality of natural resources within the park, most notably the forested environments. Regional and park-specific mitigation and adaptation strategies are needed to maintain or improve the condition of some resources over time. Success will require acknowledging a ?dynamic change context? that manages widespread and volatile problems while confronting uncertainties, managing natural and cultural resources simultaneously and interdependently, developing disciplinary and interdisciplinary knowledge, and establishing connectivity across broad landscapes beyond park borders.

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Pratt, Lawrence, and Pascal O. Girot. Synopsis of the Executive Profile of Environmental Management: Mesoamerican Subregion. Inter-American Development Bank, 2002. http://dx.doi.org/10.18235/0012222.

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This executive profile summarized here identifies the great environmental challenges of the Mesoamerican region, highlights the achievements of the last decade, and points out the future course that will guide the region's environmental management advancements. There are three main issues addressed here: natural resources management, environmental impact of urban and industrial development and the relationship between the environment and competitiveness. This document was presented at the Environment Network of the Regional Policy Dialogue's 1st Hemispheric Meeting: Towards an Effective Environmental Management held on April 4th and 5th, 2002.

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