Academic literature on the topic 'Natural immunomodulators'
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Journal articles on the topic "Natural immunomodulators"
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Meenakshi, Bindu, Harsh, and Seema Kumari. "IMMUNITY BOOSTER HERBAL PLANTS WITH THEIR USES AND CONSTITUENTS: A REVIEW." Soch – Mastnath Journal Of Science & Technology 17, no. 4 (2023): 21–44. https://doi.org/10.5281/zenodo.8013974.
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ABSTRACT Major highlights of this review are on the description about immunomodulators from plant origin with phytochemical compounds and their relevance mechanism of action. Several plants having potential immunomodulatory property have been discussed in this review, several other plants possessing similar type of activities have also been explored as natural immunomodulators. Herbal formulation may be therefore recommended for use as positive immunomodulator. There are several botanical products with potential therapeutic applications because of their efficiency, low cost and low toxicity.
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Menkudale, A. C., S. D. Deshmukh, V. C. Kulkarni, et al. "REVIEW ON AYURVEDIC PLANTS AS IMMUNOMODULATORS." International Journal of Advanced Research 9, no. 01 (2021): 399–407. http://dx.doi.org/10.21474/ijar01/12310.
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In todays era use of immunomodulators has tremendously increased to treat various human and animal diseases like viral diseases,cancer, autoimmune diseases, inflammantary conditions etc. Immunity is the bodys natural ability to identify and resist various infectious disease and disorders. Immunomodulators are biological or synthetic substances that can stimulate, suppress or modulate any aspect of immunity including adaptive as well as innate immunity. Various factors such as balanced diet,environmental temperature,stress, pathogenic and non-pathogenic bacteria,proper exercise affect the immunity. Natural drugs are used since ancient times for treatment of various diseases because of minimal side effects. Natural compounds are also used enormously as immunomodulators. There are about 1000 natural compounds having immunomodulatory effect they either affect the immune cells or affect the antibody secretion and influence the immune response. Here in this review we have discussed in detail definition of immunity,concept of immunomodulators,classification of immunomodulators,correlation between immunomodulators and Ayurveda and Ayurvedic plants having immunomodulatory activity. The main purpose of this review is to highlight efficacy of available literature on Ayurvedic plants as immunomodulators.
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Ortuño-Sahagún, D., K. Zänker, A. K. S. Rawat, S. V. Kaveri, and P. Hegde. "Natural Immunomodulators." Journal of Immunology Research 2017 (2017): 1–2. http://dx.doi.org/10.1155/2017/7529408.
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Zhao, Yue, Bocheng Yan, Zhaoyu Wang, Mingjing Li, and Wei Zhao. "Natural Polysaccharides with Immunomodulatory Activities." Mini-Reviews in Medicinal Chemistry 20, no. 2 (2020): 96–106. http://dx.doi.org/10.2174/1389557519666190913151632.
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Natural polysaccharide is a kind of natural macromolecular which can be extracted from plants, fungi, algae, animals, and bacteria. The monosaccharide compositions and glucosidic bonds of polysaccharides from different origins vary substantially. Natural polysaccharides have been shown to possess complex, important and multifaceted biological activities including antitumor, anticoagulant, antioxidative, antiviral, immunomodulatory, antihyperlipidemic and antihepatotoxic activities. Their properties are mainly due to their structural characteristics. It is necessary to develop polysaccharide immunomodulators with potential for preventive or therapeutic action. The present paper summarizes the structural features, immunostimulatory activity and the immunomodulatory mechanisms of natural polysaccharides. In particular, it also provides an overview of representative natural polysaccharide immunomodulators.
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Zebeaman, Meseret, Mesfin Getachew Tadesse, Rakesh Kumar Bachheti, Archana Bachheti, Rahel Gebeyhu, and Kundan Kumar Chaubey. "Plants and Plant-Derived Molecules as Natural Immunomodulators." BioMed Research International 2023 (June 5, 2023): 1–14. http://dx.doi.org/10.1155/2023/7711297.
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Background. Nowadays, the immunomodulatory properties of plants have been studied extensively with greater interest due to increasing awareness and combating the severity of immunomodulatory diseases. Scope and Approach. This paper highlights the efficacy of the available literature evidence on natural immunomodulators of plant origin and synthetic ones. In addition, several aspects of plants and their phytoconstituents responsible for immunomodulation have been discussed. Moreover, this review also discusses the mechanism involved in immunomodulation. Key Findings. One hundred fifty medicinal immunomodulatory plants are currently identified to find novel immunomodulatory drugs. Of these plants, the plant family Asteraceae also takes the first rank by offering 18 plant species (12%). Similarly of the plants studied so far, 40% belong to the Asteraceae family. Echinacea purpurea of this family is most known for its immunostimulating activity. The most prominent immune-active bioactive molecules are polyphenols, terpenoids, and alkaloids. Also, eight plant bioactive immunomodulators were checked for clinical trials and found in the market. These are six immunosuppressants, resveratrol, epigallocatechin-3-gallate, quercetin, colchicine, capsaicin, and andrographolide, and two immunostimulants, curcumin and genistein. Nowadays, there are a lot of polyherbal traditional medicinal products sold in the market and claimed to their immunomodulators. However, much work is still needed to find more active immunomodulatory agents. The mechanism by which immunomodulatory medicinal plant exert their effect is through the induction of cytokines and phagocyte cells and the inhibition of iNOS, PGE, and COX-2 synthesis.
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Ortuño-Sahagún, Daniel, Ajay K. S. Rawat, and Kurt Zänker. "Natural Immunomodulators 2018." Journal of Immunology Research 2019 (November 3, 2019): 1–3. http://dx.doi.org/10.1155/2019/4341698.
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Miteva, Dimitrina, Meglena Kitanova, and Tsvetelina Velikova. "Biomacromolecules as Immunomodulators: Utilizing Nature’s Tools for Immune Regulation." Macromol 4, no. 3 (2024): 610–33. http://dx.doi.org/10.3390/macromol4030037.
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Although there are numerous available immunomodulators, those of natural origin would be preferable based on their safety profile and effectiveness. The research and clinical interest in immunomodulators have increased in the last decades, especially in the immunomodulatory properties of plant-based therapies. Innovative technologies and extensive study on immunomodulatory natural products, botanicals, extracts, and active moieties with immunomodulatory potential could provide us with valuable entities to develop as novel immunomodulatory medicines to enhance current chemotherapies. This review focuses on plant-based immunomodulatory drugs that are currently in clinical studies. However, further studies in this area are of utmost importance to obtain complete information about the positive effects of medicinal plants and their chemical components and molecules as an alternative to combatting various diseases and/or prevention.
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Hifnawy, M., O. Rashwan, Z. Said, and M. Rabeh. ""immunomodulators from natural products"." Bulletin of Egyptian Society for Physiological Sciences 26, no. 1 (2006): 47–60. http://dx.doi.org/10.21608/besps.2006.37422.
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Saputro, Dominyda Vebrianto, Ahmad Shobrun Jamil, M. Artabah Muchlisin, and Irsan Fahmi Almuhtarihan. "A Network Pharmacology of Lemongrass (Cymbopogon citratus) on COVID-19 Cases." Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) 3 (November 13, 2023): 49. http://dx.doi.org/10.18860/planar.v3i0.2471.
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Various ways and treatment efforts are carried out to avoid the severe impact of COVID-19 cases, one of which is using plants as natural immunomodulatory agents. One of the plants that is proven to act as a natural immunomodulator is lemongrass (Cymbopogon citratus). This study aimed to determine the protein tissue associated with the body's immune system activated by C. citratus. The secondary metabolites of C. citratus were identified using the KNApSAck and Dr. Duke databases. Target proteins associated with plant-secondary metabolite compounds from the SwissTargetPrediction database and immunomodulatory-associated target proteins were obtained from the GeneCards database. The intersected proteins were put into StringDB and analyzed using KEGG to obtain network pharmacology. 98 secondary metabolite compounds of C. citratus were obtained from the database. Proteins associated with C. citratus contain 1096 compounds, and those related to immunomodulators contain 1380 proteins. The intersection results obtained 244 proteins predicted to interact with C. citratus and are related to immunomodulators. From the results of KEGG analysis, five pathways related to C. citratus were obtained, namely PD-L1 expression and PD-1 checkpoint pathway in cancer, Fc epsilon RI signaling pathway, Th17 cell differentiation, T cell receptor signaling pathway, and IL-17 signaling pathway. MAPK 1, MAPK 3, and MAPK 14 proteins are predicted to be in all five related pathways, and Mol 13 compounds are predicted to be able to interact with these three proteins. Thus, it can be concluded that the compound Mol 13 is the compound that plays the most role in acting as an immunomodulator in C. citratus.
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Nerkar, Amit G., and Rushikesh P. Nagarkar. "Ethnopharmacological review of anticancer activity of vinca and turmeric." Current Trends in Pharmacy and Pharmaceutical Chemistry 5, no. 3 (2023): 88–93. http://dx.doi.org/10.18231/j.ctppc.2023.020.
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Natural products with immunomodulatory effects are widely used in the treatment of many diseases, including autoimmune diseases, as well as cancer and inflammatory diseases. They have attracted great interest as therapeutic agents in recent decades because they offer inexpensive and less toxic products than synthetic chemotherapy agents. Immunomodulators are substances that have the ability to improve or suppress the host's defense response, which can be used for prevention and in combination with other treatments. The anticancer effects of these immunomodulators result from their anti-inflammatory, antioxidant and apoptosis-inducing, anti-angiogenic and anti-metastatic effects. In addition to preventing tumor growth and proliferation, these natural immunomodulators, such as curcumin and Vinca, can also be used as a preventive treatment against cancer. In contrast, immunostimulants can induce and activate humoral and cell-mediated immune responses against the tumor, which facilitates the recognition and destruction of a pre-existing tumor.
Dissertations / Theses on the topic "Natural immunomodulators"
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Oliveira, Natália Velasquez. "Estudo fitoquímico e da atividade biológica das folhas e do caule da espécie Acacia langsdorfii Benth (Leguminosaceae)." Universidade Federal de Alagoas, 2009. http://www.repositorio.ufal.br/handle/riufal/2479.
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The species Acacia langsdorfii Benth is a tree with scarce geographical distribution not happening report in the literature regarding pharmacotherapeutics properties. The genus Acacia is the largest second in the family Leguminosae and one of the largest is considered in Angiospermas, presenting more of 1.200 species presenting cosmopolitan and typical character of semi-arid hot areas distributed in tropical and temperate hot areas of everyone. The objective of this work is to contribute to the knowledge of chemical composition and biological activity of extracts derived from the leaf and stem of Acacia langsdorfii Benth, hitherto not studied. Several species of Acacia are used traditionally for the treatment of many different diseases. However, of this species, only known to their extracts show immunomodulatory activity and trypanocidal. From the hexane fraction of the stem, was isolated, by chromatographic methods, a steroid and a triterpenoid which were identified as stigmasterol and lupeol, respectively. It was isolated and purified a mixture of triterpenoid of the lupane series (where one is lupeol). The lupeol is the chemical constituent majority. From the Hexane fraction of leaves, was isolated and purified a diterpenoid and triterpenoid, which were identified as ent-atisan-7α,16α-diol and lupeol, respectively. The lupeol is the chemical constituent majority. In addition, from the ethyl acetate fraction of leaves was isolated and purified by column chromatography, two flavan-3-ols, one flavanone and two flavones which were identified by spectroscopic techniques such as catechin, epicatechin, naringenin, 4'-hydroxy-5,6,7-trimethoxyflavone and morin-3-O-rutinoside, respectively. The morin-3-Orutinoside
is the chemical constituent majority of this fraction. The structures were identified using spectroscopic techniques of IR, MS, 1D and 2D NMR (H1, C13, DEPT 90 °, 135 °, DEPT, COSY, HSQC, HMBC and NOESY), and determinations of the melting point, rotation optical and comparisons with literature data. Substances ent-atisan-7α,16α-diol, morin-3-O-rutinoside, 4'-hydroxy-5 ,6,7-trimethoxyflavone were first reported in the genus. The hexane fractions derived from both the stem and leafs showed a high rate (> 90%) inhibits activity the proliferation of Plasmodium falciparum. The fractions derived from both
the stem and leafs showed a high rate (> 80%) inhibits activity the linfoproliferation.<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>A espécie Acacia langsdorfii Benth é uma árvore com distribuição geográfica escassa não ocorrendo registro na literatura quanto às suas propriedades fármaco-terapêuticas. O gênero Acacia é o segundo maior na família Leguminosae e é considerado um dos maiores nas Angiospermas, apresentando mais de 1.200 espécies apresentando caráter cosmopolita e típico de regiões quentes semi-áridas distribuídas em regiões quentes tropicais e temperadas de todo o mundo. O objetivo deste trabalho é contribuir para o conhecimento da composição química e da atividade biológica dos extratos oriundos da folha e do caule da espécie Acacia langsdorfii Benth, até então não estudada. Diversas espécies de Acacia são utilizadas tradicionalmente para o tratamento das mais diferentes patologias. Porém, Não há registro na literatura quanto às propriedades fármaco-terapêuticas desta espécie, apenas sabe-se que seus extratos apresentaram atividade imunomoduladora e tripanocida. Da fração de hexano do caule foram isolados, por métodos cromatográficos, um esteróide e um triterpenóide, os quais foram identificados como sendo estigmasterol e lupeol, respectivamente. Também foi isolado e purificado uma mistura contendo triterpenóides da série lupano (onde um é o lupeol). Da fração hexânica das folhas foi isolado e purificado um diterpenóide e um triterpenóide, os quais foram identificados como sendo ent-atisan-7α,16α-diol e lupeol, respectivamente. Além disso, da fração acetato de etila das folhas foi isolado e purificado por cromatografia em coluna dois flavan-3-óis, uma flavanona e duas flavonas as quais foram identificadas por técnicas espectroscópicas como sendo catequina, epicatequina, naringenina, 4’-hidroxi-5,6,7-trimetoxiflavona e morina 3-O-rutinosídeo respectivamente. A morina 3-O-rutinosídeo é o constituinte químico majoritário desta fração. As estruturas foram identificadas com o uso de técnicas espectroscópicas de IV, RMN 1D e 2D (H1, C13, DEPT 90°, DEPT 135°, COSY, HSQC, HMBC e NOESY) e espectrométrica (EM), além de determinações do ponto de fusão, rotação óptica e comparações com dados da literatura. As substâncias ent-atisan-7α,16α-diol, morina 3-O-rutinosídeo, 4’-hidroxi-5,6,7-trimetoxiflavona foram relatadas pela primeira vez no gênero. As frações oriundas do hexano, tanto do caule como em folhas, apresenta um alto índice (> 90%) de atividade inibidora da proliferação do Plasmodium falciparum. As frações obtidas da partição do extrato em etanol das folhas e caule da A. langsdorfii apresentaram uma alta inibição da linfoproliferação (>80%).
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Fontes, Lívia Beatriz Almeida. "Avaliação dos efeitos da Licochalcona A e do trans-cariofileno sobre a encefalomielite autoimune experimental (EAE)." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/4282.
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Previous issue date: 2013-07-05<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais<br>A esclerose múltipla (EM) é uma doença autoimune, crônica, progressiva, inflamatória e desmielinizante do sistema nervoso central (SNC). Devido à similaridade clínica e histopatológica com esta doença, a encefalomielite autoimune experimental (EAE) apresenta um modelo clínico experimental amplamente aceito da EM, devido ao fato de ambos terem processos fisiopatológicos mediados por células Th1 e citocinas pró-inflamatórias, como Interferon-gama (INF-γ), Fator de Necrose Tumoral alfa (TNF-α) e, mais recentemente, células Th17, produtores principalmente de IL-17, e radicais oxigenados, como NO e H2O2 produzidos principalmente por células fagocitárias. Os medicamentos hoje utilizados para a EM atuam sobre esses mediadores inflamatórios, porém, apresentam inconvenientes como, custo elevado e/ou efeitos adversos pronunciados. Devido a isso, a pesquisa por novas drogas para o tratamento da EM, concentra-se em substâncias que sejam capazes de modular a produção desses mediadores inflamatórios com maiores vantagens para o paciente. No presente estudo a EAE foi induzida em camundongos fêmeas da linhagem C57BL/6 com a MOG35-55 e os animais foram tratados com a Licochalcona A (isolado e purificado a partir da Glycyrhizza inflata) em doses de 15 e 30 mg/kg/dia e com o trans-cariofileno (obtido comercialmente em doses de 25 e 50 mg/kg/dia por gavagem (via oral) a partir do 10° dia até o pico dos sintomas clínicos da doença. Para verificar o efeito deste tratamento os seguintes parâmetros foram utilizados: avaliação clínica dos animais, realizada diariamente através da pesagem e pontuação dos escores neurológicos; análise histopatológica por hematoxilina e eosina do tecido cerebral e medula espinhal; produção de NO, avaliada pelo método de Griess; produção de H2O2, pelo método de Pick & Mizel, ambos em cultura de células peritoneais;níveis de IFN-γ, IL-17, TNF-α, quantificados por ELISA no sobrenadante de cultura de esplenócitos. O resultados mostraram que tanto a Licochalcona A, como principalmente o trans-cariofileno nas maiores doses administradas causaram redução significativa na neuroinflamação e desmielinização no SNC. Os níveis de NO, H2O2, IFN-γ, IL-17, TNF-α também apresentaram acentuada redução estando correlacionados com a melhoria dos sintomas clínicos. Os resultados sugerem que a Licochalcona A e o trans-cariofileno podem modular a produção de mediadores inflamatórios, interferindo sobre a patogênese da EAE. Tais substâncias podem ser instrumentos importantes para o tratamento de doenças desmielinizantes inflamatórias do SNC, tais como a EAE, o modelo clínico experimental mais utilizado para a esclerose múltipla.<br>The multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with features to be chronic, progressive, inflammatory and demyelinating. Due to the clinical and histopathological similarity with experimental autoimmune encephalomyelitis disease (EAE) this became a widely accepted study animal model of MS because both have pathophysiological processes involving Th1 cells and soluble pro-inflammatory cytokines such as Interferon-gamma (INF-γ), tumor necrosis factor alpha (TNF-α) and more recently Th17 cells, primarily producers of IL-17, oxygen free radicals as NO and H2O2 by phagocytic cells. Drugs currently used in fact act on these inflammatory markers but have many disadvantages such as high cost and/or pronounced adverse effects. Due to that, the search for new drugs to treat MS focuses on substances that are able to modulate the production of these inflammatory mediators with greater advantages to the pacient. In the present study EAE was induced in female mice C57BL6 lineage with the MOG35-55 and the animals were treated with Licochalcone A (isolated and purified from Glycyrhizza Inflata) in doses 15 and 30 mg/Kg/dia and with trans-caryophyllene (obtained commercially in doses of 25 and 50 mg/Kg/dia by gavage (oral administration) from day 10° until the peak of the clinical symptoms of the disease. To verify the effect of this treatment the following parameters were used: clinical evaluation, was made by a neurological score of symptoms and weighing; histopathological analysis, for hematoxylin and eosin staining of the brain and spinal cord tissue at the end of the experiment; production of NO, evaluated by Griess method; production of H2O2; by Pick Mizel, both in culture of peritoneal cells; quantification of IFN-γ, IL-17, TNF-α was made by ELISA on the surface of spleen cells culture. Both Licochalcone A, as mainly the trans-caryophyllene in higher doses caused significant reduction in neuroinflamação and demyelination in the CNS. The levels of NO, H2O2, IFN-γ, IL-17, TNF-α also showed sharp reduction being correlated with the improvement of clinical symptoms. The results suggest that the Licochalcone A and trans-caryophyllene can modulate the production of inflammatory mediators, interfering on the pathogenesis of EAE. Such substances may be important instruments for treatment of CNS demyelinating inflammatory diseases such as EAE, animal model more used for multiple sclerosis.
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Steinborn, Carmen [Verfasser], Carsten [Akademischer Betreuer] Gründemann, and Reinhard [Akademischer Betreuer] Voll. "Immunomodulatory effects of selected natural products used in complementary medicine." Freiburg : Universität, 2019. http://d-nb.info/1226657230/34.
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Mallevaey, Thierry. "Etude du rôle des lymphocytes T natural killer au cours de la schistosomiase expérimentale murine." Lille 2, 2006. http://www.theses.fr/2006LIL2S006.
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Les lympocytes T Natural Killer (NKT) constituent une population hétérogène de lymphocytes T non conventionnels exprimant à la fois des marqueurs de cellules NK et de lymphocytes T. Chez la souris, les cellules NKT invariantes (iNKT), particulièrement abondantes au niveau du foie, expriment un TCR semi-invariant Vα14-Jα18, alors que les cellules NKT variantes (vNKT), principalement présentes dans le thymus et les organes lymphoïdes secondaires, possèdent un TCR plus divers. Des études récentes semblent démontrer que les iNKT et vNKT exercent des fonctions différentes in vivo. La particularité des cellules NKT est qu'elle synthétisent rapidement de grandes quantités de cytokines de typre Th1 et /ou Th2 suite à une stimulation par certains Ag glycolipidiques (exogènes ou endogènes) présentés par la molécule CD1d. Les cellules NKT jouent un rôle clé dans la régulation et la polarisation de la réponse immune dans de nombreuses pathologies cancéreuses, autoimmunes, inflammatoires ou infectieuses. Si leur rôle dans des infections par des bactéries, virus ou parasites protozoaires est clairement décrit, leur rôle dans des infections par des parasites helminthes, généralement associées à des réponses Th2, est inconnu. La schistosomiase est une maladie parasitaire chronique causée par l'helminthe trématode Schistosoma. Chez la souris, l'infection par S. Mansoni se caractérise par une réorientation de la réponse immune d'un profil de type Th1en début d'infection, vers une forte réponse Th2, au moment où les oeufs du parasite se déposent dans les tissus. Nous avons montré que le mode de présentation restreint par la molécule CD1d joue un rôle crucial dans le développement de la réponse Th2 au cours de l'infection, suggérant l'implication des cellules NKT dans ce modèle. Dans cette étude, nous montrons que les cellules NKT hépatiques et spléniques sont activées au cours de la schistosomiase murine, et que les cellules iNKT produisent de l'IFN-γ et de l'IL-4 in vivo, suite au dépôt des oeufs dans le foie. Des cellules dendritiques (DC) sensibilisées par les oeufs, mais pas par les autres stades parasitaires (schistosomules ou vers adultes), activent les iNKT de façon CD1d-dépendante et induisant la production d'IFN-γ et d'IL-4 in vitro. Dans un modèle d'immunisation par transfert de DC sensibilisées, nous montrons également que les iNKT participent au développement de la réponse Th2 dirigée contre les Ag de l'oeuf. Nos résultats semblent exclure l'implication d'un ligand microbien CD1d-restreint et suggèrent que des ligands endogènes sont générés par les DC, indépendamment de l'expression des TLR, et présentés aux iNKT par la molécule CD1d. Enfin, si les iNKT et vNKT n'ont pas de rôle majeur dans la réponse immune précoce, elles exercent des fonctions distinctes, et éventuellement complémentaires, dans le développement de la réponse immune en phase aigüe de l'infection: les iNKT participent à la réponse Th1 alors que les vNKT favorisent plutôt le développement de la réponse Th2. En conclusion, ces résultats montrent pour la première fois que des parasites helminthes peuvent activer les cellules NKT in vivo, et que ces cellules jouent un rôle majeur dans le développement de la réponse immune au cours de l'infection<br>Mouse CD1d-restricted Natural Killer T (NKT) cells represent a heterogenous population of glycolipid-reactive T cells that co-express NK and T cell markers. Among them, invariant (i)NKT, highly represented in the liver, express a semi-invariant Vα14-Jα18 TCR, whereas variant (v)NKT which are most frequent in the thymus and lymph nodes, express a more diverse TCR repertoire. Recent studies provide evidence that iNKT and vNKT cells can exert different functions in vivo. Indeed, through their ability to produce both Th1- and Th2-type cytokines upon stimulation, NKT cells play potent immunoregulatory functions during cancer, inflammation, auto-immune diseases and infections. NKT cells exert crucial roles in the immune/inflammatory system during bacterial, protozoan, fungal and viral infections. However, their roles during metazoan parasite infection, which are usually associated with strong Th2 responses, still remain elusive. Schistosomiasis is a chronic parasitic disease caused by the extracellular helminth parasite Schistosoma. A key feature of the immune response in S. Mansoni-infected mice is the occurrence of a switch a Th1 immune response, at the beginning of the infection, towards a strong Th2 response triggered by parasite eggs that are gradually deposited in host tissues. We have previously shown that CD1d plays an important rôle in the induction of Th2 responses during murine schistosomiasis, suggesting the involvment of CD1d-restricted NKT cells. In the present study, we demonstrate that splenic and hepatic NKT cells are activated during the course of murine schistosomiasis and hepatic iNKT cells produce both IFN-γ and IL-4 in vivo, following egg encounter in the liver. We also report that schistosome egg-, but not schistosomula- nor adult worm-, sensitized dendritic cells (DC) activate, in a CD1d-dependent manner, iNKT cells to secrete IFN-γ and IL-4 in vitro. Transfer of egg-sensitized DC promotes a strong Th2 response in recipient wild type mice, but not in mice that lack iNKT cells. Engagement of Toll-like receptors in DC is not necessary for iNKT cell stimulation in response to egg-sensitized DC, suggesting an alternative pathway of activation. We propose that self, rather than parasite-derived, CD1d-restricted ligands are implicated in iNKT cell stimulation. Finally, we show that whereas both iNKT and vNKT cells do not have a major impact on the immune response during the early stages of infection, they exert important,although opposite, roles on the immune response during the acute phase of the infection. INKT cells appear to provide help for Th1 cell differenciation whereas vNKT cells appear to promote that of Th2 cells. Together, these data show for the first time that helminths can activate both iNKT and vNKT cells to produce immunoregulatory cytokines in vivo, enabling them to influence the adaptive immune response
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Calla-Magariños, Jacqueline. "Bioactive leishmanicidal alkaloid molecules from Galipea longiflora Krause with immunomodulatory activity." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-81439.
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According to WHO, leishmaniasis is endemic in 98 countries, and has been placed ninth in a global analysis of infectious diseases. Treatment of leishmaniasis is based on pentavalent antimonials but toxicity and developing resistance have been reported. Traditional medicine and scientific studies have shown that the extract of Galipea longiflora Krause (Evanta) exhibits antileishmanial activity. We hypothesized that the healing observed when using this plant might not only be due to the direct action on the parasite, but possibly to a parallel effect on the host immune response. We found that an alkaloid extract of Evanta (AEE) inhibited the growth of Leishmania braziliensis promastigotes while viability of eukaryotic cells was practically not affected. We also found that AEE interfered with polyclonal activation or Leishmania-specific re-stimulation of lymphocytes, as revealed by a reduction of in vitro cellular proliferation and IFN-g production. More important, AEE treatment of mice hosting L. braziliensis showed that AEE is able to control both inflammation and parasite load. Additionally, the healing process was improved when AEE and meglumine antimoniate were administered simultaneously. Dendritic cells (DCs) play a pivotal role in T-cell stimulation and polarization of naïve T cells. Therefore, we investigated if AEE could alter the activation of DCs and if allostimulatory DCs properties were altered if activated in the presence of AEE. DCs activated in the presence of AEE reduced the production of IL-12p40 and IL-23. When we analyzed the allostimulatory capacity of AEE-treated DCs, we found that allogeneic CD4+ T-cells secreted lower levels of IFN-γ. In conclusion, this thesis provides valuable insight into the effects of Evanta derived extract. The dual effect found for AEE, on Leishmania parasite and on the immune response, suggests that AEE may be useful in controlling the parasite burden and preventing over-production of inflammatory mediators and subsequently avoiding tissue damage.<br><p>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Accepted. Paper 3: Submitted.</p>
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Dauguet, Nicolas. "Rôle immunomodulateur du lenalidomide sur les cellules Natural Killer humaines : étude des effecteurs lymphoïdes cytotoxiques chez les patients atteints de leucémies aiguës myéloïdes en 1ère rémission complète." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/1057/.
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La plupart des patients atteints de leucémies aiguës myéloïdes (LAM) sont en rémission complète après la chimiothérapie d'induction (1ère RC). Or, la persistance de cellules cancéreuses résistantes aux traitements et à la réponse immunitaire engendre de nombreuses rechutes. Nos travaux montrent la prééminence et la persistance de cellules NK CD56bright immatures chez ces patients en 1ère RC. Ainsi, tout agent ou tout protocole favorisant la reconstitution ou potentialisant les fonctions cytotoxiques des cellules NK pourrait être bénéfique. Nous avons ainsi choisi d'évaluer le rôle du Lenalidomide sur les cellules NK de donneurs sains. Nos travaux montrent, pour la 1ère fois, un effet direct mais cependant complexe sur les cellules NK. En effet, le Lenalidomide augmente l'expression du CD56 mais diminue la production d'IFN-gamma deux effets qui s'opposent au regard de la description classique des cellules NK CD56bright. L'augmentation du CD56 ne présagerait pas d'un effet bénéfique sur les cellules NK des patients LAM en 1ère RC. De plus, la modulation de l'expression de divers récepteurs de lyse n'a pas d'impact sur les fonctions cytotoxiques de ces effecteurs. Cependant, la diminution de l'expression de l'IFN-gamma pourrait être bénéfique car ce dernier favorise l'expression des molécules du CMH-I par les cellules leucémiques de LAM et inhibant ainsi l'activité cytotoxique des cellules NK. Les nombreuses actions du Lenalidomide sur le microenvironnement tumoral encouragent à poursuivre l'étude de ces effets dans les LAM<br>Most Acute Myeloide Leukemia (AML) patients achieve complete remission after induction chemotherapy (1st CR). Nevertheless, persistence of resistant tumor cells to treatments and immune response is associated with high risk of relapse. Our works highlight a pre-eminence and persistence of immature CD56 bright NK cells in patients at 1st CR. Thus, every agent or protocol dedicated to improve reconstitution or to potentiate cytotoxic functions of NK cells would be beneficial. Thus, we have chosen to evaluate the role of Lenalidomide upon NK cells of healthy donors. Our works show, for the first time, a direct but complexe effect on NK cells. Indeed, Lenalidomide upregulates the CD56 expression but decreases IFN-gamma production, two opposite effects with respect to the classical description of CD56bright NK cell population. The upregulation of CD56 do not augur a beneficial effect on NK cells of AML patients in 1st CR. Moreover, the modulation of expression of various lytic receptors has no impact on NK cell cytotoxic functions. However, the decrease of IFN-gamma expression coulb be beneficial as it upregulates MHC-I expression on AML leukemic cells and inhibit NK cell cytotoxic activity. The wide range of Lenalidomide actions on tumoral microenvironment is a strong support to pursue the study of its effects on AML
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Pathak, Sanmoy. "Immunomodulatory effects of 7-hydroxy frullanolide, a plant-based sesquiterpene lactone, in inhibiting immune cell responses and roles of disease and vaccination outcomes on Covid-19 mortality." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/4873.
Full textAbstract:
Immunomodulation is a process by which the immune response of the host is either enhanced or
suppressed due to various factors which either protects or makes the host more susceptible to
particular diseases. Immunomodulators are a broad class of drugs that are used either to suppress
(immunosuppressants) or enhance (immunostimulants) immune responses. These have been used
to combat against the dysregulated immune system, observed during tissue/organ transplantation
and disorders such as rheumatoid arthritis, ulcerative colitis and cancer.
Plant-based immunomodulators such as capsaicin, curcumin and resveratrol are extensively used
as immunomodulators and anti-inflammatory drugs. Sesquiterpene lactones are a major class of
plant-based immunomodulators that are derivatives of sesquiterpenoids and are obtained from
Asteraceae. These molecules are known for its anti-inflammatory and anti-tumor effects. The
objective of my first study was to understand the roles of 7-hydroxy frullanolide (7HF) on different
immune cells and to decipher the underlying mechanisms of action. Primary CD4+ T cells were
isolated from lymph nodes of C57BL/6 mice, followed by treatment with different doses of 7HF
and in-vitro activation with plate bound (pb) αCD3 and soluble αCD28. 7HF in a dose dependent
manner caused a reduction in IL2 production and inhibition of upregulation of CD69, an early
activation marker in CD4+ T cells. Subsequently, it was also observed that 7HF abrogated the
increase in cell size and cellular proliferation with T cell activation. Ca2+
-dependent signaling pathways are an indispensable part of CD4+ T cell activation and overall T cell responses; hence it
was important to understand whether 7HF had any effects on Ca2+ levels. Surprisingly, 7HF
increased intracellular Ca2+ levels, more than optimal levels, during CD4+ T cell activation at early
timepoints. We functionally confirmed this observation using a specific intracellular Ca2+ chelator,
BAPTA-AM which rescued cellular proliferation with 7HF treatment during CD4+ T cell
activation. To understand how 7HF caused a significant increase in intracelullar Ca2+ amounts, we
performed Ca2+ channel inhibitor studies to understand whether 7HF behaved as a Ca2+ channel
agonist in CD4+ T cells. Additionally, 7HF also caused a significant increase in extracellular lactate
amounts which was functionally confirmed using 2-Deoxy D-glucose (2DG) experiments
suggesting that 7HF was working on multiple fronts to hinder T cell responses. Subsequently, we
tried to understand whether there was a link between increased Ca2+ levels and lactate levels during
CD4+ T cell activation. Finally, to understand whether there is a link between Ca2+ and lactate,
experiments were done using BAPTA-AM that confirmed Ca2+ levels did regulate lactate levels
during CD4+ T cell activation. Next, we tried to understand the effect 7HF had on other immune cells. Although 7HF had no
effect on lipopolysaccharide (LPS) stimulated splenocytes which primarily activates B cells, 7HF
did inhibit activation of LPS treated adherent peritoneal macrophages with respect to nitrite and
IL6 amounts in a dose dependent manner. Furthermore, 7HF inhibited peritoneal macrophage
activation via a Ca2+ dependent mechanism. Ca2+ channel inhibitor studies also suggested that 7HF
was behaving as a Ca2+ channel agonist in peritoneal macrophages, similar to CD4+ T cells.
However, 7HF had no effect on lactate levels in peritoneal macrophages as compared to CD4+ T
cells. Lastly, we wanted to identify the molecular mechanisms by which 7HF was acting as a Ca2+
agonist. Thus, we performed autodocking experiments using the autodock modelling simulation
software and standardized the binding of 7HF to Ca2+ channels. We initially obtained the crystal
structure of the Ca2+ channel proteins, IP3R and TRPV1 and tried to dock the 3D structure of the
ligands into the respective pockets of the protein molecules. We observed that 7HF was binding
to both TRPV1 and IP3R Ca2+ channels with a significant binding energy when compared to the
positive controls. Hence it is likely that 7HF behaved as a Ca2+ channel agonist to greatly increase
Ca2+ amounts that inhibited both T cell and macrophage responses.
To understand the physiological relevance of 7HF, we performed in-vivo experiments with 7HF
using the Dextran sulfate sodium (DSS) induced colitis model of mice which is an animal model
of autoimmune Inflammatory Bowel Disease. We used the golden standard of estimating the
severity of colitis by measuring the colon length. DSS, as reported, caused a severe shortening of
colon length which was rescued by 7HF in a dose dependent manner. The extent of colon damage
as observed due to severe damage in the crypts and extensive immune cell infiltration by DSS was
significantly reduced by 7HF. Also, 7HF rescued the loss in thymocyte and mesenteric lymph node
(MLN) cell numbers due to DSS treatment. Finally, 7HF significantly reduced the amounts of
proinflammatory cytokines, IFNγ and IL6 in the sera. Overall, this study clearly demonstrates the
in-vivo effects of 7HF as an anti-inflammatory molecule. Both in-vitro and in-vivo studies together
strengthen the observation that 7HF may have potential therapeutic applications to treat different
autoimmune disorders.
My next study was performed during the Covid-19 pandemic. An epidemiological study was
performed during the months of April-June 2020 to understand the effects of pathogen exposure
and vaccination coverage on Covid-19-induced mortality. Covid-19 deaths display a high
heterogeneity across different countries and the extent of infection in a particular population might
be dependent on multiple factors such as age, sex, temperature, humidity etc. This led us to perform
correlation studies with 36 (out of 215) countries having more than 1000 Covid-19 deaths as of
24th June 2020. The major observations of this study are: measles, HBV and polio vaccination
coverage had no correlation with Covid-19 incidences and deaths. Subsequently, flu incidences
had no correlation with respect to Covid-19 incidences and deaths. However, flu deaths showed a
significant negative correlation with Covid-19 mortality rate and Covid-19 deaths/million.
Additionally, flu vaccination had a significant positive correlation with Covid-19 incidences,
Covid-19 deaths, mortality rate and Covid-19 deaths/million. Next, Tuberculosis (TB) only
negatively correlated with Covid-19 mortality rate and Covid-19 deaths/million. This trend was
also holding for TB deaths. Similarly, Bacillus Calmette Guerin (BCG) coverage had a significant
negative correlation with Covid-19 deaths, mortality rate and Covid-19 deaths/million suggesting
its protective role. Interestingly, countries which have flu, but no BCG, vaccination show highest
number of Covid-19 deaths. Countries that have high flu and BCG vaccinations demonstrate more
immunomodulatory effects in determining the fate of a particular disease and its effects on the
host.
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Gonçalves, Mafalda Bessa Martins. "Bioengineering an immunomodulatory microenvironment for bone healing." Doctoral thesis, 2022. https://hdl.handle.net/10216/139290.
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Ferreira, Joana Rita Cardoso Brandão e. Pinto. "Exploring Mesenchymal Stem/Stromal Cells Immunomodulatory Potential in Intervertebral Disc Degeneration." Doctoral thesis, 2021. https://hdl.handle.net/10216/139666.
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Dias, Ana Sofia Couto Bizarro de Castro. "Study of antitumor and immunomodulatory activities of wild mushroom extracts." Master's thesis, 2014. http://hdl.handle.net/1822/34565.
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Dissertação de mestrado em Genética Molecular<br>Mushrooms and their compounds are widely appreciated, not only for their nutritional but also for their medicinal properties. In fact, the search for various bioactive properties in different mushroom extracts or in the compounds isolated from those mushroom has been the focus of attention from the scientific community working in the area of natural products. The present work has focused on the study of the antitumor and immunomodulatory properties of extracts from three different mushrooms. Thus, the first aim of the present work was to gain insight into the mechanism of action of a methanolic extract of Cordyceps militaris in the non-small cell lung cancer cell line NCI-H460, since this extract had previously been shown to have tumour cell growth inhibitory activity in this cell line in particular. In addition, the second aim was to study the immunomodulatory activity of the Suillus luteus polysachararidic (PLS) extract and of the Morchella esculenta phenolic extract, using the monocytic THP-1 cell line which differentiates into machrophages upon stimulation.
The response of NCI-H460 cells to the methanolic extract of C. militaris was studied regarding its effect on cellular viability, proliferation, cell cycle profile, apoptosis and DNA damage. Results showed that treatment with the methanolic extract of C. militaris caused a decrease in NCI-H460 cellular proliferation, a cell cycle arrest at G0/G1 and an increase in apoptosis. Interestingly, treatment with the extract was shown to increase the cellular levels of p53 and p21. Moreover, this study also showed evidence of cellular DNA damage caused by this extract, since increased levels of P-H2A.X and 53BP1 foci/cell were observed. Overall, this part of the work suggested that the methanolic extract of C. militaris affected NCI-H460 cellular viability through a mechanism which involved DNA damage and p53 activation.
In addition, preliminary experiments were carried out to gain insight into the immunomodulatory potential of a PLS extract of S. luteus and of a phenolic extract of M. esculenta in THP-1 cells. Results showed that neither of the extracts presented cytotoxicity towards THP-1 cells or induced THP-1 monocytes differentiation into macrophages. Interestingly, the PLS extract of S. luteus caused a dose-dependent increase in the metabolic activity of THP-1 monocytes, probably due to increased proliferation. These preliminary results need be further confirmed and continued in future work.
Overall, the work carried out in this thesis further supports the potential of mushrooms extracts in the search for bioactive compounds.<br>Os cogumelos e seus compostos são muito apreciados, não só pelas suas propriedades nutricionais, mas também pelas medicinais. De facto, a procura de propriedades bioativas em diferentes extratos de cogumelos ou em compostos isolados desses cogumelos, tem sido um foco de interesse da comunidade científica que trabalha na área de produtos naturais. O presente trabalho visou o estudo de propriedades antitumorais e imunomoduladoras de extratos de três cogumelos diferentes. Assim sendo, como primeiro objetivo deste trabalho pretendeu-se analisar o mecanismo de ação de um extrato metanólico de Cordyceps militaris na linha celular NCI-H460 (de cancro do pulmão de não pequenas células), uma vez que tinha sido previamente demonstrado que este extrato inibe o crescimento celular, destas células em particular. Além deste, um segundo objetivo visou o estudo da atividade imunomoduladora de um extrato polisacarídico (PLS) de Suillus luteus e de um fenólico de Morchella esculenta, usando a linha celular monocítica THP-1 que se diferencia em macrófagos, após estimulação.
Foi estudada a resposta das células NCI-H460 ao tratamento com o extrato metanólico de C. militaris relativamente ao efeito na viabilidade celular, proliferação, perfil do ciclo celular, apoptose e no dano no DNA. Os resultados demonstraram que o tratamento com o extrato metanólico de C. militaris nas células NCI-H460 diminuiu a proliferação celular, bloqueou o ciclo celular nas fases G0/G1 e induziu apoptose. De particular interesse foi o facto de este extrato causar um aumento dos níveis de p53 e p21. Para além disso, este estudo também mostrou ainda evidências de danos no DNA causados por este extrato, dada a observação de aumento quer nos níveis de P-H2A.X como no número de 53BP1 foci/célula. Em geral, esta parte do trabalho sugeriu que o extrato metanólico de C. militaris diminuiu a viabilidade celular das células NCI-H460 por um mecanismo que envolve a ativação de danos no DNA e de p53.
Neste trabalho, foram realizadas experiências preliminares para averiguar o potencial imunomodulador de um extrato PLS de S. luteus e de um extrato fenólico de M. esculenta em células THP-1.
Os resultados demonstraram que nenhum dos extratos analisados apresentou citotoxicidade para células THP-1 ou induziu a diferenciação desta linha celular de monócitos em macrófagos. De particular interesse foi o facto de se verificar que o extrato PLS do S. luteus causou um aumento (dependente da dose) da atividade metabólica de monócitos THP-1, provavelmente devido ao aumento da proliferação celular. Estes resultados preliminares terão ainda de ser confirmados num trabalho futuro, assim como o potencial imunomodulador destes extratos.
De um modo geral, o trabalho realizado nesta tese contribui para a descrição do potencial dos extratos de cogumelos na busca de compostos bioativos.
Books on the topic "Natural immunomodulators"
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International Symposium on Standardization of the Immunopharmacology of Natural and Synthetic Immunomodulators (1991 Annecy, France). International Symposium on Standardization of the Immunopharmacology of Natural and Synthetic Immunomodulators: Proceedings of a symposium. Karger, 1992.
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Mahajan, Girish B. Natural Immunomodulators: Promising Therapy for Disease Management. Bentham Science Publishers, 2023.
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Nikam;, Vandana S. Natural Immunomodulators: Promising Therapy for Disease Management. Bentham Science Publishers, 2023.
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Nikam;, Vandana S. Natural Immunomodulators: Promising Therapy for Disease Management. Bentham Science Publishers, 2023.
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Sŭmatʻŭ nano ipcha rŭl iyonghan chʻŏnyŏnmul yurae yangni hwalsŏng mulchil (hangamje, myŏnyŏk hwalsŏngje) ŭi yangmul chŏndal yudo misairhwa e kwanhan yŏnʼgu: Chʻoejong yŏnʼgu kaebal kyŏlgwa pogosŏ = A study on the development of new drug delivery system with anticancer agents and immunomodulators derived from natural products using smart nano missiles. Pogŏn Pokchibu, 2004.
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Standardization of the Immunopharmacology of Natural and Synthetic Immunomoducators (Dynamic Nutrition Research). S. Karger Publishers (USA), 1992.
Find full textBook chapters on the topic "Natural immunomodulators"
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Saha, Shubhajit, Azubuike V. Chukwuka, Nimai Chandra Saha, Caterina Faggio, and Hamed Mousavi Sabet. "Natural and Synthetic Immunomodulators." In Immunomodulators in Aquaculture and Fish Health. CRC Press, 2023. http://dx.doi.org/10.1201/9781003361183-3.
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Yasri, S., and V. Wiwanitkit. "Colchicine and Andrographolide as Natural Immunomodulators." In Nutraceuticals and Functional Foods in Immunomodulators. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2507-8_11.
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Gupta, Charu, and Dhan Prakash. "Phytochemicals as the Source of Natural Immunomodulator and Their Role in Cancer Chemoprevention." In Immunomodulators and Human Health. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6379-6_7.
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Ahire, Eknath D., Khemchand R. Surana, Vijayraj N. Sonawane, et al. "Immunomodulation Impact of Curcumin and Its Derivative as a Natural Ingredient." In Nutraceuticals and Functional Foods in Immunomodulators. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2507-8_10.
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Mishra, Jyotika, Adarsh Sahu, Namrata Kushwaha, et al. "Nutraceuticals as Immunomodulators." In The Nature of Nutraceuticals. Apple Academic Press, 2024. https://doi.org/10.1201/9781003518969-11.
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Wagner, Hildebert, Stefan Kraus, and Ksenija Jurcic. "Search for potent immunostimulating agents from plants and other natural sources." In Immunomodulatory Agents from Plants. Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8763-2_1.
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Danishefsky, S. J., M. Inoue, and D. Trauner. "Synthesis of Immunomodulatory Marine Natural Products." In The Role of Natural Products in Drug Discovery. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-04042-3_1.
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Tejashwini, S., C. Dhaarini, and M. Gayathri. "Biosynthesis of the Immunomodulatory Bioactive Molecule." In Sustainable Landscape Planning and Natural Resources Management. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-76859-0_6.
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Wang, Jing, Lingjun Ma, Fei Zhou, Fang Wang, Lei Chen, and Jianbo Xiao. "Pathway and Genomics of Immunomodulator Natural Products." In Plants and Phytomolecules for Immunomodulation. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8117-2_4.
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Kijjoa, A. "Plant Secondary Metabolites with Immunomodulatory Activity." In Natural Products in the New Millennium: Prospects and Industrial Application. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-015-9876-7_31.
Full textConference papers on the topic "Natural immunomodulators"
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Gosteva, T. A., V. V. Solodky, V. V. Zolin, and O. P. Os’kina. "TOXICITY OF ESSENTIAL OILS AND THEIR ANTIVIRAL ACTIVITY AGAINST THE SARS-COV-2 VIRUS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-180.
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Essential oils of some plants are used in medicine as anti-inflammatory, immunomodulatory, antimicrobial and antiviral agents. Natural essential oils perform the functions of protecting plants from pests, accidents, viruses, as well as from low and high temperatures [1–3].
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Kurashova, S., M. Egorova, A. Vetrova, et al. "IMMUNOMODULATORY EFFECT OF ADJUVANTS IN THE EXPERIMENTAL HANTAVIRUS VACCINE." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-96.
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Hemorrhagic fever with renal syndrome (HFRS) is a viral non-transmissible zoonosis that occupies a leading position among natural focal human diseases in the Russian Federation. In view of the lack of etiotropic drugs for the treatment of this infection, the development of an effective preventive vaccine is of particular importance. In order to reduce the amount of antigen, increase the immunogenicity and reduce reactogenicity, we studied the adjuvants of various origins in the experimental vaccine against HFRS.
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Coombs, Morgan, Tyrone Dowdy, Masud Alam, et al. "992 Immunomodulatory nature of glioblastoma-derived lipids against human NKT cells." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0992.
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Yakuboğulları, N., D. Sağ, A. Çağır, and E. Bedir. "Semi-synthetic studies on astragaloside VII and immunomodulatory activities of the derivatives." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400088.
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Mustafa, NK, MM Mukhtar, Al Dawi AF, and S. Khalid. "Immunomodulatory effect of Acacia nilotica pods on Leishmania parasitized THP-1 macrophage cells." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400047.
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Su, W. J., S. F. Huang, J. Y. Feng, and Y. Y. Yang. "Isoniazid as an Immunomodulatory Agent for Latent Tuberculosis Infection Treatment in View of Invariant Natural Killer T (iNKT Cells." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4427.
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Hsu, Andy, Hang Quach, Tsin Tai, et al. "Abstract 5619: Natural killer cell function in multiple myeloma is impaired by dexamethasone and can not be rescued by immunomodulatory drugs." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5619.
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Alcolea, Marla, Renata Moraes Brito, Mahmi Fujimori, Adenilda Cristina Honorio-França, Eduardo Luzia França, and Paula Becker Pertuzatti. "IMMUNOMODULATORY EFFECTS OF HONEY FROM STINGLESS BEES AND HONEY BEES ON BREAST CANCER CELLS." In Brazilian Breast Cancer Symposium 2022. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s2002.
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Objective: The limitations of current cancer treatments and their side effects have led to a growing interest in the study of natural compounds and alternative therapies such as apitherapy. Honey has in its constitution several substances that contribute to neutralize free radicals, such as phenolic compounds of which stand out in flavonoids and phenolic acids, besides having important antimicrobial and antitumor activities. However, the mechanisms of the antitumor action of honey and how the characteristics of honey of different species influence this mechanism are poorly understood. The aim of this study was to verify the antitumor action of honey bees (Apis mellifera) and stingless bees (Tetragonisca angustula) honey in mammary adenocarcinoma cell lines (MCF-7). Methods: Cell viability analyses were performed using fluorescence and flow cytometry methods, and oxidative balance through the release of superoxide anion (O2 − ) and production of the enzyme superoxide dismutase (SOD) in human peripheral blood mononuclear (MN) cells, MCF-7, and coculture of both. Results: Viability analyses in MN cells showed that honey samples, at concentrations of 100 mg/mL, 100 ng/mL, and 100 pg/mL, do not present cytotoxicity to cells. But in MCF-7 cells, there was a decrease in viability with stingless bee honey (100 mg/mL), showing the highest cytotoxic action and reducing the viability of cancer cells by 30.4%. The same honey sample caused an immunomodulatory effect on both MN and cancer cells, stimulating greater release of O2 − and SOD enzyme activity in these cells. While in the coculture, there was a greater release of O2 − and a decrease in enzymatic activity. Conclusion: The results showed that especially stingless bee honey acts on the oxidative stress of cells, and this might be the mechanism related to its antitumor action. Thus, honey can play a potential role as a preventive agent and complementary therapy against breast cancer.
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Pulford, John F., Ekaterina Murzin, Z. Michael, et al. "378 Transcriptional and proteomic insights into the immunomodulatory nature of SUPLEXA cells: an autologous cellular therapy for cancers." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.0378.
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Ibishi, Bardha, Vesna Karapetkovska-Hristova, Nexhbedin Beadini, Bardhyl Limani, and Ivan Pavlović. "Dietary inclusion of propolis and thyme enhances growth performance in broiler chickens." In 7th International Scientific Conference Modern Trends in Agricultural Production, Rural Development and Environmental Protection. The Balkans Scientific Center of the Russian Academy of Natural Sciences, 2025. https://doi.org/10.46793/7thmtagricult.14i.
Full textAbstract:
The rising demand for organic and residue-free poultry products has increased interest in natural feed additives as alternatives to synthetic growth promoters. This study evaluated the effects of Thymus vulgaris (thyme) and raw propolis supplementation on the growth performance of broiler chickens reared under extensive conditions. A total of 40 cross-breed day-old chicks were used in a seven-week experiment conducted in a village in the Polog region. The birds were assigned to control and treatment groups, receiving either 25 g kg-1 thyme, 3 g kg-1 propolis, or 6 g kg-1 propolis in their diets through out the trial. Body weights were recorded weekly, and statistical analyses were conducted to evaluate the effects of the treatments. No significant differences in body weight were observed during the first six weeks of fattening (p > 0.05). However, in the seventh week, broilers supplemented with 6 g kg-1 propolis exhibited a statistically significant increase in body weight compared to the control and lower-dose propolis groups (p < 0.01). These findings suggest a dose- and time-dependent response, indicating that prolonged supplementation and higher inclusion levels may be necessary to achieve measurable growth benefits. The delayed effect may be related to metabolic adaptations and improved nutrient utilization influenced by the antioxidant and immunomodulatory properties of propolis and thyme. The results support the potential of propolis and thyme as natural and effective growth promoters, particularly in sustainable and regionally adapted poultry systems where antibiotic use is restricted. This study contributes to the growing body of evidence supporting phytogenic feed additives as viable alternatives to antibiotics, addressing concerns related to antimicrobial resistance and consumer preference for natural poultry products.
Reports on the topic "Natural immunomodulators"
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Annunziato, Dominick. HPLC Sample Prep and Extraction SOP v1.3 for Fungi. MagicMyco, 2023. http://dx.doi.org/10.61073/sopv1.3.08.11.2023.
Full textAbstract:
medicine, industry, and biotechnology. Fungi produce a wide range of bioactive compounds, such as alkaloids, antibiotics, antifungals, immunomodulators, anticancer agents, enzymes, and vitamins. However, these compounds are often locked inside the fungal cell wall, which is composed of chitin, a tough substance that is dif�icult to digest by humans1. Therefore, it is essential to have a good extraction technique that can break down the chitin and release the valuable compounds from the fungi, this is especially essential in the laboratory for accurate lab assays and potency determination during routine HPLC chromatography analysis. During licensure and/ or certi�ication any given lab will be required to take a pro�iciency test which gauges the lab’s pro�iciency at measuring a given matrices for accurate evaluation. They evaluate our abilities to run the gear and accurately measure the potency of what was extracted; however, at the time of this writing none existed for extraction of the fungal material itself, so this remains a variable between testing labs. It is important that we openly share our extraction techniques for evaluating fungi materials speci�ically for the clean extraction of active alkaloids for which potency can be measure via chromatography and/or spectrometry devices. In this way hopefully creating less variables between testing lab and more concise results. In this paper, we present a novel sample prep and extraction technique for fungi that uses speci�ic solvent composition in conjunction with M.A.E (microwave assisted extraction) in 75% methanol , 25% water which helps break the cell wall to release the compounds. Also used is an ultrasonication unit and vortex mixer. Our technique quickly releases all the available alkaloids for accurate chromatography measurements in just two hours, forty-�ive minutes with minimal handling. We demonstrate the effectiveness and ef�iciency of our technique by applying it to magic mushroom fruit bodies for the extraction of tryptamines namely psilocybin and its active derivative psilocin; however, this technique can be used for other species of fungi and compounds like Cordyceps/ cordycepin or Lions’ mane/ erinacines, etc.. We also compare our technique with other popular methods in terms of extraction techniques, digestion times and solvent compositions. Our results show that our technique is superior to the others in terms of time and effectiveness while pulling all the active compounds and not degrading them. Our extraction technique for fungi chromatography analysis offers a new and improved way to access the natural products of fungi and explore their potential for various biotechnological applications. We hope that our technique will inspire further research and innovation in the field of fungal extraction and natural product.
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Brown Horowitz, Sigal, Eric L. Davis, and Axel Elling. Dissecting interactions between root-knot nematode effectors and lipid signaling involved in plant defense. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598167.bard.
Full textAbstract:
Root-knot nematodes, Meloidogynespp., are extremely destructive pathogens with a cosmopolitan distribution and a host range that affects most crops. Safety and environmental concerns related to the toxicity of nematicides along with a lack of natural resistance sources threaten most crops in Israel and the U.S. This emphasizes the need to identify genes and signal mechanisms that could provide novel nematode control tactics and resistance breeding targets. The sedentary root-knot nematode (RKN) Meloidogynespp. secrete effectors in a spatial and temporal manner to interfere with and mimic multiple physiological and morphological mechanisms, leading to modifications and reprogramming of the host cells' functions, resulted in construction and maintenance of nematodes' feeding sites. For successful parasitism, many effectors act as immunomodulators, aimed to manipulate and suppress immune defense signaling triggered upon nematode invasion. Plant development and defense rely mainly on hormone regulation. Herein, a metabolomic profiling of oxylipins and hormones composition of tomato roots were performed using LC-MS/MS, indicating a fluctuation in oxylipins profile in a compatible interaction. Moreover, further attention was given to uncover the implication of WRKYs transcription factors in regulating nematode development. In addition, in order to identify genes that might interact with the lipidomic defense pathway induced by oxylipins, a RNAseq was performed by exposing M. javanicasecond-stage juveniles to tomato protoplast, 9-HOT and 13-KOD oxylipins. This transcriptome generated a total of 4682 differentially expressed genes (DEGs). Being interested in effectors, we seek for DEGs carrying a predicted secretion signal peptide. Among the DEGs including signal peptide, several had homology with known effectors in other nematode species, other unknown potentially secreted proteins may have a role as root-knot nematodes' effectors which might interact with lipid signaling. The molecular interaction of LOX proteins with the Cyst nematode effectors illustrate the nematode strategy in manipulating plant lipid signals. The function of several other effectors in manipulating plant defense signals, as well as lipids signals, weakening cell walls, attenuating feeding site function and development are still being studied in depth for several novel effectors. As direct outcome of this project, the accumulating findings will be utilized to improve our understanding of the mechanisms governing critical life-cycle phases of the parasitic M. incognita RKN, thereby facilitating design of effective controls based on perturbation of nematode behavior—without producing harmful side effects. The knowledge from this study will promote genome editing strategies aimed at developing nematode resistance in tomato and other nematode-susceptible crop species in Israel and the United States.