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Journal articles on the topic 'Natural neuroprotectants'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Sakshi, Jatale* Rupali Chopade Vedangi kulkarni Shivani Chavan Shatrughna Nagrik Dr. Shivshankar Mhaske. "Phytochemicals in Neurodegenerative Diseases: Natural Neuroprotectants." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4065–89. https://doi.org/10.5281/zenodo.15507301.

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Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) pose significant challenges due to their progressive nature and lack of effective treatments. Phytochemicals, bioactive compounds derived from plants, have gained increasing attention for their neuroprotective properties, including antioxidant, anti-inflammatory, and anti-apoptotic effects. This review explores the role of key phytochemicals such as curcumin, resveratrol, quercetin, epigallocatechin gallate (EGCG), and ginsenosides in modulating cellular pathwa

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2

Babadjouni, Robin Moshe, Ryan E. Radwanski, Brian P. Walcott, et al. "Neuroprotective strategies following intraparenchymal hemorrhage." Journal of NeuroInterventional Surgery 9, no. 12 (2017): 1202–7. http://dx.doi.org/10.1136/neurintsurg-2017-013197.

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Intracerebral hemorrhage and, more specifically, intraparenchymal hemorrhage, are devastating disease processes with poor clinical outcomes. Primary injury to the brain results from initial hematoma expansion while secondary hemorrhagic injury occurs from blood-derived products such as hemoglobin, heme, iron, and coagulation factors that overwhelm the brains natural defenses. Novel neuroprotective treatments have emerged that target primary and secondary mechanisms of injury. Nonetheless, translational application of neuroprotectants from preclinical to clinical studies has yet to show benefic

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3

Muench, Gerald, Anton Rahmadi, Annette Maczurek, and Megan L. Steele. "O4-05-06: A versatile microglia-neuron co-culture system for the identification of anti-inflammatory neuroprotectants: Application to screening of natural compounds." Alzheimer's & Dementia 6 (July 2010): S158. http://dx.doi.org/10.1016/j.jalz.2010.05.493.

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4

Cliver, Richard N., Natalia Castro, Thais Russomano, et al. "Antioxidants Derived from Natural Products Reduce Radiative Damage in Cultured Retinal Glia to Prevent Oxidative Stress." Neuroglia 3, no. 3 (2022): 84–98. http://dx.doi.org/10.3390/neuroglia3030006.

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Retinal pathologies have been heavily studied in response to radiation and microgravity, including spaceflight-associated neuro-ocular syndrome (SANS), which is commonly developed in space flight. SANS has been characterized in clinical studies of astronauts returning to Earth and includes a range of symptoms, such as globe flattening, optic-disc edema, retinal folds, and retinal ischemia. In cases of retinal insult, Müller glia (MG) cells respond via neuroprotective gliotic responses that may become destructive to produce glial scarring and vison loss over time. Retinal pathology is further i

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Phung, Hung Manh, Sullim Lee, and Ki Sung Kang. "Protective Effects of Active Compounds from Salviae miltiorrhizae Radix against Glutamate-Induced HT-22 Hippocampal Neuronal Cell Death." Processes 8, no. 8 (2020): 914. http://dx.doi.org/10.3390/pr8080914.

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Oxidative stress is considered one of the factors that cause dysfunction and damage of neurons, causing diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD).Recently, natural antioxidant sources have emerged as one of the main research areas for the discovery of potential neuroprotectants that can be used to treat neurological diseases. In this research, we assessed the neuroprotective effect of a 70% ethanol Salvia miltiorrhiza Radix (SMR) extract and five of its constituent compounds (tanshinone IIA, caffeic acid, salvianolic acid B, ro

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Rout, Sradhasini, Bandana Rath, Subrat Kumar Bhattamisra, Anjan Kumar, Ishani Rath, and Preetish Kumar Panigrahy. "Neuroprotective effect of methanolic extract of Sargassum wightii on rotenone-induced parkinsonism-like symptoms in Wistar albino rats." Journal of Herbmed Pharmacology 10, no. 4 (2021): 468–75. http://dx.doi.org/10.34172/jhp.2021.54.

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Introduction: The pathogenesis of Parkinson’s disease (PD) is multifactorial in which oxidative stress, neuroinflammation, and mitochondrial dysfunction are the leading factors. Currently, the antioxidant and anti-inflammatory agents of natural sources as neuroprotectants have raised much attention. The current study aimed to explore the neuroprotective effect of methanolic extract of Sargassum wightii in male Wistar albino rats against rotenone-induced PD. Methods: The rats were administered with rotenone (10 mg/kg orally) daily for 28 days to induce PD. S. wightii (200 mg/kg and 400 mg/kg) a

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7

Okeowo, Oritoke. "NEUROPROTECTANT ACTIVITY OF NATURAL COMPOUNDS IN STRESS." IBRO Neuroscience Reports 15 (October 2023): S49. http://dx.doi.org/10.1016/j.ibneur.2023.08.2153.

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8

Perusse, Dimitri, and Michael J. Smanski. "Stereoselective semi-synthesis of the neuroprotective natural product, serofendic acid." MedChemComm 10, no. 6 (2019): 951–60. http://dx.doi.org/10.1039/c9md00145j.

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9

Kesari, Kavindra Kumar, Anupam Dhasmana, Shruti Shandilya, et al. "Plant-Derived Natural Biomolecule Picein Attenuates Menadione Induced Oxidative Stress on Neuroblastoma Cell Mitochondria." Antioxidants 9, no. 6 (2020): 552. http://dx.doi.org/10.3390/antiox9060552.

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Several bioactive compounds are in use for the treatment of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. Historically, willow (salix sp.) bark has been an important source of salisylic acid and other natural compounds with anti-inflammatory, antipyretic and analgesic properties. Among these, picein isolated from hot water extract of willow bark, has been found to act as a natural secondary metabolite antioxidant. The aim of this study was to investigate the unrevealed pharmacological action of picein. In silico studies were utilized to direct the investigation towa

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10

Kaewkaen, Pratchaya, Terdthai Tong-un, Jintanaporn Wattanathorn, Supaporn Muchimapura, Wiroje Kaewrueng, and Sathaporn Wongcharoenwanakit. "Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/263520.

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Nowadays, the preventive strategy of vascular dementia, one of the challenge problems of elderly, has received attention due to the limitation of therapeutic efficacy. In this study, we aimed to determine the protective effect and possible mechanism of action of mulberry fruit extract on memory impairment and brain damage in animal model of vascular dementia. Male Wistar rats, weighing 300–350?g, were orally given mulberry extract at doses of 2, 10 and 50?mg/kg at a period of 7 days before and 21 days after the occlusion of right middle cerebral artery (Rt.MCAO). It was found that rats subject

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11

Khanna, Archita, and Surendra Kumar Trigun. "Resveratrol modulates NMDAR-nNOS axis in the cerebellum of a neuroexcitotoxic model of Hepatic encephalopathy." Journal of Scientific Research 67, no. 04 (2023): 12–20. http://dx.doi.org/10.37398/jsr.2023.670403.

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Resveratrol (RSV), a natural plant derived phytoalexin, is known to exhibits its biological activity by activating Sirt1 which confers neuroprotection under a variety of neurological complications like ischemia, Alzheimer’s disease etc. Hepatic Encephalopathy (HE) is a disorder of mental activity, neuromuscular function and consciousness that occurs as a result of liver dysfunction, involving Nmethyl-D-aspartate receptor (NMDAR) over activation in brain cells, causing excitotoxicity. Therapeutic modulation of this glutamate receptor, therefore,needs to be investigated to define cerebral mechan

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12

Yuliani, Sapto, Dwi Utami, Laela Hayu Nurani, et al. "Purple Yam (Dioscorea alata) Extract Increasing Dopamine Levels and Improving the Brain's Microscopic Features in Parkinson's Model Mice." Borneo Journal of Pharmacy 8, no. 2 (2025): 127–34. https://doi.org/10.33084/bjop.v8i2.7267.

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Parkinson's disease (PD) is a severe neurodegenerative disorder, that causes progressive motor issues from the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNpc). Purple yam (Dioscorea alata), rich in anthocyanins, shows promise as a natural antioxidant and neuroprotectant. This study investigated the antiparkinsonian effects of D. alata extract on dopamine levels and brain microscopic features in a haloperidol-induced PD mouse model. Thirty-five male mice were randomly allocated into seven groups: normal (CMC-Na and aqua pro injection), haloperidol-induced negativ

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13

Sheng, Longxiang, Bingzheng Lu, Hui Chen та ін. "Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway". Marine Drugs 17, № 5 (2019): 267. http://dx.doi.org/10.3390/md17050267.

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High intraocular pressure (IOP)-induced retinal ischemia leads to acute glaucoma, which is one of the leading causes of irreversible visual-field loss, characterized by loss of retinal ganglion cells (RGCs) and axonal injury in optic nerves (ONs). Oxidative stress and the inflammatory response play an important role in the ischemic injury of retinal and optic nerves. We focus on 5α-androst-3β, 5α, 6β-triol (TRIOL), a synthetic neuroactive derivative of natural marine steroids 24-methylene-cholest-3β, 5α, 6β, 19-tetrol and cholestane-3β, 5α, 6β-triol, which are two neuroactive polyhydroxysterol

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14

Hsu, Chiao-Ling, Yao-Tseng Wen, Tzu-Chao Hsu, et al. "Neuroprotective Effects of Erinacine A on an Experimental Model of Traumatic Optic Neuropathy." International Journal of Molecular Sciences 24, no. 2 (2023): 1504. http://dx.doi.org/10.3390/ijms24021504.

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Erinacine A (EA), a natural neuroprotectant, is isolated from a Chinese herbal medicine, Hericium erinaceus. The aim of this study was to investigate the neuroprotective effects of EA in a rat model of traumatic optic neuropathy. The optic nerves (ONs) of adult male Wistar rats were crushed using a standardized method and divided into three experimental groups: phosphate-buffered saline (PBS control)-treated group, standard EA dose-treated group (2.64 mg/kg in 0.5 mL of PBS), and double EA dose-treated group (5.28 mg/kg in 0.5 mL of PBS). After ON crush, each group was fed orally every day for

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15

Singh, Ayushi, Lucy Mohapatra, Deepak Mishra, Rahul Kumar Maurya, Narahari Narayan Palei, and Alok Shiomurti Tripathi. "Phytoconstituents enhancing learning and cognition by targeting the gut-brain axis." Journal of Mountain Research 19, no. 2 (2024). https://doi.org/10.51220/jmr.v19-i2.51.

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The gut-brain axis, a sophisticated network of communication that links the brain and the gastrointestinal tract, plays a critical part in preserving cognitive function and overall mental health. A recent study has brought to light the ability of phytoconstituents bioactive substances derived from plants to modify this axis and improve cognitive function. These organic substances are present in fruits, vegetables, herbs, and other plant-based foods and work through different pathways to produce their effects, such as those of antioxidants, neuroprotectants, and anti-inflammatory agents. Phytoc

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16

Battaglini, Denise, Dorota Siwicka-Gieroba, Patricia RM Rocco, et al. "Novel Synthetic and Natural Therapies for Traumatic Brain Injury." Current Neuropharmacology 19 (February 25, 2021). http://dx.doi.org/10.2174/1570159x19666210225145957.

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: Traumatic brain injury (TBI) is a major cause of disability and death worldwide. The initial mechanical insult results in tissue and vascular disruption with hemorrhages and cellular necrosis that is followed by a dynamic secondary brain damage that presumably results in additional destruction of the brain. In order to minimize deleterious consequences of the secondary brain damage-such as inflammation, bleeding or reduced oxygen supply. The old concept of the -staircase approach- has been updated in recent years by most guidelines and should be followed as it is considered the only validate

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17

de Sousa, Natália Ferreira, Luciana Scotti, Érika Paiva de Moura, et al. "Computer Aided Drug Design Methodologies With Natural Products In The Drug Research Against Alzheimer's Disease." Current Neuropharmacology 19 (October 5, 2021). http://dx.doi.org/10.2174/1570159x19666211005145952.

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: Natural products are compounds isolated from plants that provide a variety of lead structures for the development of new drugs by the pharmaceutical industry. The interest in these substances increases because of their beneficial effects on human health. Alzheimer's disease (AD ) affects occur in about 80% of individuals aged 65 years. AD is the most common cause of dementia in elderly people, is characterized by progressive neurodegenerative alterations, as decrease of cholinergic impulse, increased toxic effects caused by reactive oxygen species and the inflammatory process that the amyloi

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18

Rout, Sradhasini, Bandana Rath, Subrat Kumar Bhattamisra, Ishani Rath, and Anjan Kumar. "Effects of Sargassum wightii Methanolic Extract on L-Methionine Induced Experimental Vascular Dementia like Syndrome in Albino Wistar Rats." Journal of Pharmaceutical Research International, November 2, 2021, 255–64. http://dx.doi.org/10.9734/jpri/2021/v33i47b33122.

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Sargassum wightii is brown seaweeds with high nutritive value with natural bioactive compounds having diverse therapeutic activity. In recent years, research on Sargassum wightii has gain much interest in neuropharmacological field. Basing on neuroprotective effect of Sargassum wightii against Parkinson’s disease animal models, the possible protective effect on dementia is hypothesised. Addressing this question the present study was designed to investigate the effect of S. wightii on L-methionine induced vascular dementia like syndrome in male wistar albino rats. Vascular dementia was induced

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19

Mani, Rupesh Kumar, Madhura M. Bose, Swati Mittal, Muthukumar A, and Salahuddin Md. "A systemic review on neuroprotective potential of cucurbita pepo on neurological disease." International Journal of Health Care and Biological Sciences, July 28, 2023, 7–10. https://doi.org/10.46795/ijhcbs.v4i3.465.

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Neurodegeneration has become a very serious issue in all over the world and in order to curb the same, it is better to opt for natural therapy to prevent future occurrence and retrogression of the disease. The Pharma-market is outflown with various chemical derived drugs with long term side-effects and no assurance for complete cure. Alternative to this would be herbal treatment which may be underrated yet have high prospective for preventing progression or stagnation of the disease. This review highlights the therapeutic potential of various parts of Cucurbita pepo (C.pepo) for treating diffe

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20

Mustafa, Aya M., Ghadir A. Bastawesy, Shymaa Hatem, et al. "Polyphenolic protection: the role of mangiferin in mitigating neurodegeneration and neuroinflammation." Inflammopharmacology, July 22, 2025. https://doi.org/10.1007/s10787-025-01854-3.

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Abstract Mangiferin, a polyphenol of natural occurrence predominantly present in Mangifera indica, has attracted significant interest because of its multiplicity of pharmacological activities, of which its neuroprotective activity is of particular interest. Herein, the review delves into the biosynthetic mechanisms, structural properties, and action mechanisms responsible for the therapeutic value of mangiferin in neurological disorders. Of special note is that mangiferin has antioxidative, anti-inflammatory, and anti-apoptotic activities, which are responsible for its effectiveness in reducin

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21

Almohaimeed, Hailah M., Hanan Waly, Nasser S. Abou Khalil, Khaled M. A. Hassanein, Basal Sulaiman M. Alkhudhairy, and Elham A. Abd-Allah. "Gum Arabic nanoformulation rescues neuronal lesions in bromobenzene-challenged rats by its antioxidant, anti-apoptotic and cytoprotective potentials." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-24556-0.

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AbstractBromobenzene (BB) is a hazardous environmental contaminant because of its multiple routes of exposure and the toxicity of its bio-derivates. It could elicit neuronal alterations by stimulating redox imbalance and apoptotic pathways. Gum Arabic (GA) protected the hippocampus of a type 2 diabetic rat model from cognitive decline. Whether gum Arabic nanoemulsion (GANE) can increase the neuroprotectant potency of GA in fighting BB-associated neurological lesions is the question to be answered. To accomplish this objective, 25 adult male Wistar rats were randomly and equally assigned into f

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22

Demirel, Göksun, Sonia Sanajou, Anil Yirün, et al. "Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum‐induced neurotoxicity in an in vitro Alzheimer's disease model." Journal of Applied Toxicology, November 21, 2023. http://dx.doi.org/10.1002/jat.4564.

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AbstractAlzheimer's disease (AD) is a progressive neurological disorder that affects various cognitive functions, behavior, and personality. AD is thought to be caused by a combination of genetic and environmental factors, including exposure to aluminum (Al). Virgin coconut oil (VCO) may have potential as a natural neuroprotectant against AD. Aim of this study was to determine neuroprotective effects of VCO on Al‐induced neurotoxicity in an in vitro AD model. SH‐SY5Y cells were initially cultured in normal growth medium and then differentiated by reducing fetal bovine serum content and adding

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