Academic literature on the topic 'Natural phenol compound'
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Journal articles on the topic "Natural phenol compound"
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Sheeraz, Khan Rasheedy. "Medical use of Phenol." International Journal of Current Science Research and Review 05, no. 03 (2022): 711–18. https://doi.org/10.5281/zenodo.6363257.
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Abstract : In organic chemistry, phenols, in some cases called phenolic, are a class of substance compounds comprising of at least one hydroxyl gatherings (- OH) fortified straightforwardly to a sweet-smelling hydrocarbon bunch. The easiest is phenol, C_6 H_5 OH. Sorption of phenolic compounds is an exceptionally perplexing cycle and many variables impact it. Toward the start, definite compound construction of phenols is given its ramification for actual properties, for instance, benefits of dissolving and edges of boiling over, solvency in water, pKa and Log P. Additionally impact of enacting and deactivating substituents on the properties is clarified. On this premise, cooperation with the most often utilized sorbents, for instance, artificially changed silica’s, polymers and permeable carbons, is depicted. Phenol is a kind of natural compound. It has a somewhat sweet aroma that could help you to remember some place that is clean, for example, a medical clinic room. In restricted amounts, it’s accessible for quite a long time and wellbeing related employments.
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Nekrasova, Larisa P., A. G. Malysheva, and E. G. Abramov. "TRANSFORMATION OF PHENOL AND DIATOMIC PHENOLS IN SURFACE WATER UNDER THE IMPACT OF NATURAL PHYSICAL AND CHEMICAL FACTORS." Hygiene and sanitation 98, no. 11 (2019): 1206–11. http://dx.doi.org/10.18821/0016-9900-2019-98-11-1206-1211.
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Introduction. Phenol, as well as diatomic phenols, are among the most common and priority organic pollutants of the environment. Getting into the water with sewage in real conditions of pollution, under the influence of natural physicochemical factors, phenols, as highly reactive compounds, undergo a transformation, as a result of which new, sometimes more toxic compounds may be formed. Purpose of the study is to investigate the transformation processes under the impact of the natural physicochemical factors of phenol, hydroquinone, pyrocatechin, and resorcinol in surface water. Material and methods. The processes of transformation of phenol and diatomic phenols were studied by the methods of spectrophotometry and luminescence spectroscopy. Absorption spectra were recorded with a UV-1800 spectrophotometer (Shimadzu, Japan), and fluorescence spectra were recorded on a CM2203 spectrofluorometer (Solar CJSC, Belarus). The degradation of phenols to CO2 and H2O (mineralization) at room temperature in natural samples was determined using a TOC-VCHP total carbon analyzer (Shimadzu, Japan). Results. The decrease in phenol concentration in river water was subject to linear dependence. The transformation kinetics of resorcinol corresponded to a sequential reaction. The processes of transformation of hydroquinone and pyrocatechin were dominated by chemical oxidation processes. Hydroquinone completely transformed within 24 hours. The degree of conversion of pyrocatechol 87.5% was achieved in 3 days and did not change during the month. During the month, the mineralization of phenol amounted to 90%, hydroquinone, and pyrocatechol - 55% and 45%, respectively. The complete transformation of resorcinol occurred in 7 days. A compound having a bright fluorescence and constituting a product of resorcinol polycondensation, whose concentration increased during the whole experiment, was formed. The degree of mineralization of resorcinol was 93%. Conclusion. The transformation of phenol, hydroquinone, pyrocatechin, and resorcinol in the surface water is caused by the processes of natural chemical and biochemical oxidation and depends on the chemical composition and concentration of presented impurities.
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Amin, A.H., A. Helmi, and A.S. Youssef. "Inducing Resistance in Olive Seedlings against Olive Psyllid, Euphyllura straminea Using Natural Phenol Compound." Greener Journal of Agricultural Sciences 3, no. 4 (2013): 295–98. https://doi.org/10.15580/GJAS.2013.4.020313432.
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Olive psyllid <em>Euphyllura straminea</em> Loginova was recorded as a key pest in Egypt in 1988 on olive trees in El Arish and caused considerable losses in fruit yield. This work aims at evaluating the toxic and repellent effect of a natural phenol compound (3, 4 dihydroxy phenol ethanol) to control and induce resistance to olive seedlings against this insect pest under insectary conditions. Results showed that percentages of reduction of insect population were increased as the phenol compound concentrations increased. The reduction percentage of nymphs and adults were reached 100% after 15, 18, 21 days at concentration of 1.0, 0.75 and 0.5 mM, respectively. Also this compound was more effective on nymphal stage than adults. Spraying this natural phenol compound (3, 4 dihydroxy phenol ethanol) could be used to control and induce resistance to olive seedlings against this pest infestation. Also results indicated that increasing concentration of 3,4 – DHPE found to prolong the protective period from 17, 27 and 35 days at 0.50, 0.75 and 1.00 mM concentrations, respectively. Therefore this compound could be used to induce resistance of olive trees against olive psyllid infestation.
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Calani, Luca, Letizia Bresciani, Margherita Rodolfi, et al. "Characterization of the (Poly)Phenolic Fraction of Fig Peel: Comparison among Twelve Cultivars Harvested in Tuscany." Plants 11, no. 22 (2022): 3073. http://dx.doi.org/10.3390/plants11223073.
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(1) Background: The fig tree (Ficus carica L.) is widely cultivated in the Mediterranean area and it produces fruits largely consumed in the Mediterranean diet. Previous studies have shown that this fruit represents a rich source of (poly)phenols, which are mainly located in the peel rather than the pulp. In our study, fig peel derived from twelve different cultivars located in Tuscany was assessed for its (poly)phenol profile. (2) Methods: The (poly)phenol characterization was performed through ultra-high performance liquid chromatography coupled to multiple-stage mass spectrometry. (3) Results: Twenty-eight (poly)phenolic compounds were quantified in the investigated fig peel. It was possible to observe an interesting variability in the (poly)phenol content among the twelve cultivars of fig peel. Rutin and 5-caffeoylquinic acid were the main compounds in the greenish fig peel, while cyanidin-3-O-rutinoside was the main component in the dark-violet fig peel. (4) Conclusions: fig peel could be used as a (poly)phenol-rich ingredient in several food products to increase the bioactive compound content of foods. Moreover, dark-violet peel could be considered potentially suitable as a natural food colorant.
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Okoronkwo, Nnenna Ejije, Jude Chibuzor Igwe, Nkemakolam Bright Nwosu, Precious Onyinyechi Chukwu, Udoka Ifunnaya Chukwukere, and Perculiar C. Ihedigbo. "Exploring Allelochemical Compositions in The Roots of Two Varieties of Anacardium occidentale (Cashew)." Biology, Medicine, & Natural Product Chemistry 13, no. 1 (2024): 297–303. http://dx.doi.org/10.14421/biomedich.2024.131.297-303.
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Allelochemicals are chemicals released by plants that affect other plants and pests. The chemicals are provided by different parts of the plant or released through the natural decomposition of the associated plants. Anacardium occidentale has been reported to exhibit allelopathy. The bark and inner parts of the roots of the two varieties (red and yellow) of Anacardium occidental (Linn) were qualitatively and quantitatively analysed for the presence of allelochemicals. The samples were also subjected to Gas Chromatography-Mass Spectrometry (GC/MS) analysis. The qualitative results showed that flavonoids, tannins, and phenols were present in both the bark and inner parts of the roots, whereas alkaloids, saponins, and terpenoids were present only in the bark of the roots. The quantitative results showed that while the root bark of the red variety had the highest saponin content, that of the yellow variety had the highest phenol content. The GC/MS results for both samples showed the presence of different compounds, and one of the compound peaks observed in the inner root was not identified; 9,12– octadecadienoic acid (fatty acid) was the compound with the highest composition identified in the yellow variety. Similar compounds were identified in the root bark of the red and yellow varieties, which include 3-Tridecyl phenol with molecular formula C19H32O and molecular weight 276, which occurred at a retention time range of 41.703–41.712 min and had the lowest percentage compositions of 2.816 and 4.732% in red and yellow varieties, respectively. The compounds with the highest percentage compositions of 32.389 and 41.944% in red and yellow, respectively, were identified as (Z)-3-(Heptadec-10-en-1-yl) phenol (molecular formula C23H38O with molecular weight 330), occurring within the retention time range of 48.246 – 48.263 min. Other compounds with higher percentage compositions were identified in the samples, including (Z)-3-(pentadec-8-en-1-yl) phenol and 3-((4Z,7Z)-Heptadeca-4,7-dien-1-yl) phenol. However, 1,2,4,-Benzenetriol (molecular formula C6H6O with molecular weight 252) was only identified in the red variety, with a percentage composition of 8.883%, which occurred at a retention time of 22.040 min. The compounds identified in the bark were mostly phenols, whereas those in the inner roots were more fatty acids.
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Li, Meiyu, Yize Liu, Fanjie Hu, Hongwei Ren, and Erhong Duan. "Amino Acid-Based Natural Deep Eutectic Solvents for Extraction of Phenolic Compounds from Aqueous Environments." Processes 9, no. 10 (2021): 1716. http://dx.doi.org/10.3390/pr9101716.
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The environmental pollution of phenol-containing wastewater is an urgent problem with industrial development. Natural deep eutectic solvents provide an environmentally friendly alternation for the solvent extraction of phenol. This study synthesized a series of natural deep eutectic solvents with L-proline and decanoic acid as precursors, characterized by in situ infrared spectrometry, Fourier transform infrared spectrometry, hydrogen nuclear magnetic resonance spectrometry, and differential thermogravimetric analysis. Natural deep eutectic solvents have good thermal stability. The high-efficiency extraction of phenol from wastewater by natural deep eutectic solvents was investigated under mild conditions. The effects of natural deep eutectic solvents, phenol concentration, reaction temperature, and reaction time on phenol extraction were studied. The optimized extraction conditions of phenol with L-prolin/decanoic acid were as follows: molar ratio, 4.2:1; reaction time, 60 min; and temperature, 50 °C. Extraction efficiency was up to 62%. The number of extraction cycles can be up to 6, and extraction rate not less than 57%. The promising results demonstrate that natural deep eutectic solvents are efficient in the field of phenolic compound extraction in wastewater.
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Betz, Richard. "The structure of ortho-(trifluoromethyl)phenol in comparison to its homologues – A combined experimental and theoretical study." Open Chemistry 16, no. 1 (2018): 745–56. http://dx.doi.org/10.1515/chem-2018-0066.
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AbstractThe molecular and crystal structure of commercially-availableortho-(trifluoromethyl)phenol were determined by means of single-crystal X-ray diffractometry (XRD) and represent the first structural characterization of anortho-substituted (trihalomethyl) phenol. The unexpected presence of a defined hydrate in the solid state was observed.Intermolecular contacts and hydrogen bonding were analyzed. The compound was further characterized by means of multi-nuclear nuclear magnetic resonance (NMR) spectroscopy (1H,13C{1H},19F) and Fourier-Transform infrared (FT-IR) vibrational spectroscopy. To assess the bonding situation as well as potential reaction sites for reactions with nucleophiles and electrophiles in the compound by means of natural bonding orbital (NBO) analyses, and density functional theory (DFT) calculations were performed for the title compound as well as its homologous chlorine, bromine and iodine compounds. As far as possible, experimental data were correlated to DFT data.
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Mączka, Wanda, Martyna Twardawska, Małgorzata Grabarczyk, and Katarzyna Wińska. "Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties." Antibiotics 12, no. 5 (2023): 824. http://dx.doi.org/10.3390/antibiotics12050824.
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The main purpose of this article is to present the latest research related to selected biological properties of carvacrol, such as antimicrobial, anti-inflammatory, and antioxidant activity. As a monoterpenoid phenol, carvacrol is a component of many essential oils and is usually found in plants together with its isomer, thymol. Carvacrol, either alone or in combination with other compounds, has a strong antimicrobial effect on many different strains of bacteria and fungi that are dangerous to humans or can cause significant losses in the economy. Carvacrol also exerts strong anti-inflammatory properties by preventing the peroxidation of polyunsaturated fatty acids by inducing SOD, GPx, GR, and CAT, as well as reducing the level of pro-inflammatory cytokines in the body. It also affects the body’s immune response generated by LPS. Carvacrol is considered a safe compound despite the limited amount of data on its metabolism in humans. This review also discusses the biotransformations of carvacrol, because the knowledge of the possible degradation pathways of this compound may help to minimize the risk of environmental contamination with phenolic compounds.
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Bhattacharyya, Sanjay K., Bhavani S. Parmar, Rabindra Mukhopadhyay, and Abhijit Bandyopadhyay. "ANALYSIS OF AUTOHESION AND PHYSICO-MECHANICAL PROPERTIES (MULTIFUNCTIONAL BEHAVIOR) OF THE COAGULUM FROM THE LATEX OF EUPHORBIA CADUCIFOLIA HAINES VIS-À-VIS COMPARISON AGAINST SYNTHETIC RESINS IN NATURAL RUBBER COMPOUNDS." Rubber Chemistry and Technology 88, no. 3 (2015): 421–36. http://dx.doi.org/10.5254/rct.15.85937.
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ABSTRACT Soft and tacky mass recognized as whole coagulum (Cog) and its toluene soluble fraction (TE) obtained through coagulation of latex of Euphorbia caducifolia Haines has been investigated in this article as green tackifier cum multifunctional agent in natural rubber (NR) based gum compounds. It was observed that inclusion of TE and Cog in the formulations increased tack strength over the control compound (without TE and Cog). At the same loading, autohesion for natural and commercial coumarone indene resin was found comparable. However, phenol formaldehyde (non–heat reactive octyl phenol formaldehyde) resin demonstrated highest tack strength among all the NR compositions studied. Presence of various functional groups such as esters/carboxylic acid, carbon–carbon unsaturation, and so on, in natural resin activated the system and reduced the activation energy barrier for curing. The optimized composition with 5 phr TE showed nearly 5% reductions in activation energy over the control compound. However, no such cure acceleration was displayed by Cog. Unaged tensile properties of the compounds with natural resin at similar proportions to commercial resins were found comparable. Retention of tensile properties after aging for the vulcanizates with TE was better than those with the commercial resins. For Cog, however, the retention of elongation at break and tensile strength were slightly higher compared with tensile modulus.
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Gami, Afilah Abd, M. Y. Shukor, Khalilah Abdul Khalil, Farrah Aini Dahalan, Ariff Khalid, and Siti Aqlima Ahmad. "Phenol and its toxicity." Journal of Environmental Microbiology and Toxicology 2, no. 1 (2014): 11–23. http://dx.doi.org/10.54987/jemat.v2i1.89.
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The present of phenol and phenolic compound pollutant are the common problems faced by worldwide population due to natural and chemical process that comes from either industrial or human activity. Exceeding the standard level in our environment was not a new issue nowadays especially in developed or developing countries. The study concerning to the phenolic compound was started in the early 1908 where researchers started to look for solution and are interested in phenol-related research due to its toxicity and ability to retain in environment for a long period. Higher level of phenol leakage within the environment can actually affects the whole ecosystem. A toxicological property of phenol has been contributed by the formation of organic and free radical species and also due to its hydrophobicity. The structure of phenol itself shows its reactivity which lead to its properties like persistence in environment, toxicity and the possibilities of carcinogenic properties toward living organism.
Dissertations / Theses on the topic "Natural phenol compound"
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Cetin-Karaca, Hayriye. "EVALUATION OF NATURAL ANTIMICROBIAL PHENOLIC COMPOUNDS AGAINST FOODBORNE PATHOGENS." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_theses/652.
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Raw and processed foods are vulnerable to contamination during their production, distribution and sale. Thus, a wide variety of chemical preservatives are used in the food industry to prevent the growth of food spoilage and pathogenic bacteria. However, health and economic concerns have led to an intensive search for natural alternatives, such as plant extracts, that can safely be used as substitutes for synthetic antimicrobials and preservatives to partially or completely inhibit the growth of bacteria.
This study evaluated the antimicrobial effects of natural phenolic compounds extracted from vegetables, fruits, herbs and spices. The main objective was to determine the lowest concentration of phenolics to inhibit the visible growth of the pathogenic bacteria which is defined as the minimum inhibitory concentration (MIC).
Some of the most common Gram-positive and Gram-negative foodborne pathogens were treated with several natural phenolic compounds. Concentrations of 5, 10, 15, and 20 ppm (pH 5-6) of each compound were evaluated by broth micro-dilution method and the MICs were determined by using official density (OD) assay. The results demonstrated that the phenolic compounds have varying antimicrobial activities against foodborne pathogens. Natural sources of phenolic compounds contain major antibacterial components and have great potential to be used as natural antimicrobials and food preservatives.
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Kennedy, Michael James. "Natural and enhanced wood durability from pine heartwood phenolics." Thesis, Queensland University of Technology, 1996. https://eprints.qut.edu.au/107122/1/z%20T%28S%29%20108%20Natural%20and%20enhanced%20wood%20durability%20fro%20pine%20heartwood%20phenolics.pdf.
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Wood is a naturally occurring, complex, structured, polymeric material comprised of a structural matrix in which are embedded a vast variety of extractible compounds. The organic carbon-rich matrix is susceptible to biodeterioration by a wide range of bacterial, fungal, insect and other organisms, despite protective effects of the extractives. Wood preservatives developed over the past 50 years have provided efficient ways of preventing biodeterioration, but many of them are under threat from
an increasingly chemophobic populace. Naturally bioactive wood extractives offer promise of control of many wood destroying organisms, and may be more acceptable
than these more powerful synthetic biocides. Phenolic compounds, relatively abundant extractives from the heartwood of Pinus spp., plantation-grown worldwide,
were evaluated for bioactivity.
Heartwood from Pinus spp. containing elevated phenolic concentrations was more resistant to subterranean termites than that from species characterized by low phenolics. While the stilbene phenolics were poorly related to resistance, the flavonoid phenolics appeared to be more closely associated with resistance. However, unspecified additional heartwood compounds contributed strongly to termite resistance. Both Pinus el/iottii and Pinus caribaea, previously classed with Pinus radiata as susceptible to termite attack, were naturally resistant to two significant Australian termite species. Acceptance of this resistance has enabled previous limitations on unpenetrated heartwood in these spp. to be removed from Australian requirements for preservative treatment against termites, with consequent economic benefit to the preservative treatment industry and consumers.
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Matos, Melanie S. "Exploring the potential of natural extracts obtained from winemaking waste streams for cosmetic applications." Master's thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2017. http://hdl.handle.net/10362/79299.
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"Phenolic compounds present in grapes have been widely explored as cosmetic principles, because of their renowned antioxidant activity and proven ability to directly inhibit certain enzymes relevant for skin ageing.
The winemaking process generates large amounts of waste streams, thus recovery of phenolic bioactive compounds from residues and further incorporation in cosmetic products represents a promising market opportunity for wine producers, and may contribute to a sustainable development of the sector.(...)"<br>N/A
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Mullins, Alastair Patrick. "The interaction of metal ions with naturally occuring phenolic compounds." Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306807.
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Lepoittevin, Jean-Pierre. "Phenols, diphenols et cyclohexanediols a longues chaines derives d'allergenes naturels." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13103.
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Synthese par une nouvelle methode totalement stereoselective de trans,trans alkyl-3 cyclohexanediols-1,2. Synthese du cis,trans pentadecyl-3 cyclohexanediol-1,2. Activite allergisante et tolerogenique, vis a vis de l'urushiol de ces composes. Approche de la synthese de trans,trans alcenyl-3 cyclohexanediol-1,2. Isolement et structure des principaux composes aromatiques et lipidiques de ginkgo biloba l. Isolement et structure de nouvelles (-) alkyl-3 hydroxy-8 dihydro 3,4 isocoumarines. Isolement et structure de nouveaux nonacosanesdiols. Oxydation en position non activee, par l'acide metachloroperbenzoique des acides anacardiques et des cardanols. Activite allergisante des principaux aromatiques de ginkgo biloba l. Synthese d'un catechol porteur d'un complexe tris-bipyridyle du ruthenium comme sonde de microscopie electronique
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Herrera, Hernández María Guadalupe. "Structural and functional effects of natural phenolic compounds on rhodopsin mutants associated with retinitis pigmentosa." Doctoral thesis, Universitat Politècnica de Catalunya, 2017. http://hdl.handle.net/10803/461174.
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Dietary polyphenols represent a group of secondary metabolites which widely occur in fruits, vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. Previous studies have shown the interaction of certain phenolic compounds with estrogen and adenosine receptors, belonging to the G-protein coupled receptors (GPCRs) superfamily. GPCRs are the largest family of signal transduction molecules involved in most of the physiological processes.
Rhodopsin is the prototypic member of GPCRs. This receptor is the major protein found in the disks membrane of the outer segments of retinal rod photoreceptor cells and the first with resolved crystal structure. Mutations in rhodopsin are associated with retinitis pigmentosa (RP), a group of inherited visual diseases causing retinal degeneration due to progressive loss of rod and cone photoreceptors cells and leading to blindness. Several studies have been carried out on rhodopsin RP mutants in order to elucidate the molecular mechanism of the disease. This is the first step before suitable therapeutic approaches can be developed. Some of the proposed treatments are based on pharmacological rescue, in which small molecules known as chemical or pharmacological chaperones bind and stabilize misfolded opsins. Polyphenols have been proposed as useful agents against retinal toxicity but no clear evidence of these compounds at the molecular level of the visual phototransduction System has been presented so far.
Given the interest in finding new ligands to compensate the deleterious effects of RP mutations, the aim of this thesis was to evaluate the effect of the polyphenols on the structure and function of the visual pigment rhodopsin RP mutants and to study their preferences to bind to rhodopsin.
Herein we found that polyphenols quercetin (Q), resveratrol (R) and epigallocatechin gallate decreased the expression of wild-type and mutant rhodopsins when added to eukaryotic cell cultures. However, no differences were observed in the biophysical and functional properties of immunopurified pigments regenerated with 11-cis-retinal chromophore treated with O and R al concentrations of 1 µM and 10 µM Our molecular docking complementary analysis indicated that the polyphenol compounds studied can bind to rhodopsin and could act as allosteric ligands for rhodopsin regenerated with 9-cis-retinal as a chromophore.
Our results showed that Q improved the percentage and rate of regeneration of opsin with 9-cis-retinal when compared to 11-cis-retinal. Q enhances the structural compaction around the Schiff Base linkage between the retinal chromophore and opsin, preventing the chemical retinal trapping reagent hydroxylamine from easily entering in the retinal pocket. Moreover, functional experiments on wild-type and G90V mutant rhodopsin regenerated with 9-cis-retinal in presence of 1 µM Q, showed a sigmoidal kinetics clearly representative of cooperative binding. Furthermore, the presence of Q bound to rhodopsin was demonstrated by HPCL-MS analysis.
In summary, it has been shown, by using complementary molecular biology and analytical methods and in silico computational studies that some polyphenol compounds, and particularly quercetin, can act as allosteric modulators of 9-cis-rhodopsin. This effect is particularly significant in the case of the G90V mutation associated with the retinal degenerative disease RP, where the deleterious properties of the mutation could be partially compensated, and opens novel possibility of using such compounds in the treatment of visual neurodegeneration such as that associated to RP.<br>Los polifenoles de la dieta representan, un grupo de metabolitos secundarios los cuales se encuentra ampliamente en frutas y vegetales, vino, te, aceite de oliva extra virgen, chocolate y otros productos de cacao. Estudios previos han mostrado la interacción de algunos compuestos fenólicos con receptores de estrógeno y adenosina, pertenecientes a la superfamilia de receptores acoplados a proteína G (GPCRs). Estos GPCRs son la familia más grande de moléculas de transducción de señales involucradas en la mayoría de procesos fisiológicos. Rodopsina es el miembro prototípico de GPCRs y es la proteína mayoritaria encontrada en la membrana de los discos del segmento exterior de los bastones, células fotoreceptoras de la retina, y el primer con la estructura cristalina resuelta. Mutaciones en rodopsina se han asociado con retinosis pigmentaria (RP), un grupo de enfermedades visuales hereditarias que causan degeneración retiniana la cual lleva a la pérdida progresiva de las células fotoreceptoras, bastones y conos. Causando ceguera. Numerosos estudios sobre mutantes de RP se han llevado a cabo con la finalidad de elucidar los mecanismos moleculares de la enfermedad como un primer paso necesario antes de que se puedan desarrollar enfoques terapéuticos adecuados. Algunos de los tratamientos propuestos se basan en el rescate farmacológico, en el cual moléculas pequeñas conocidas como chaperonas químicas o farmacológicas se unen y estabilizan opsinas mal plegadas. Los polifenoles se han propuesto como agentes útiles contra la toxicidad retiniana, pero hasta ahora no se ha presentado evidencia clara de los efectos de estos compuestos a nivel molecular del sistema de fototransducción visual. Dado el interés en encontrar nuevos ligandos que puedan compensar los efectos causados por mutaciones de RP, el objetivo de esta tesis fue evaluar el efecto de los polifenoles sobre la estructura y función la rodopsina y mutantes de RP G90V, Y102H e 1307N y estudiar las preferencias de unión a rodopsina Se encontró al adicionar quercetina (Q), resveratrol (R) y epigalocatequin galato en células eucariotas, éstos afectan la expresión de la rodopsina nativa y de mutantes estudiados. Por otro lado, no se observaron diferencias en las propiedades biofísicas y funcionales de los pigmentos inmunopurificados regenerados con el cromofóro 11-cis retinal tratados con Q y R a concentraciones de 1 µM y 10 µM. Nuestro análisis complementario de acoplamiento molecular indicaron que los compuestos fenólicos estudiados aquí pueden unirse a rodopsina y podrían actuar como ligandos alostéricos para rodopsina unidos al cromóforo 9-cis-retinal. Analizando los resultados de las propiedades espectrales y bioquímicas de rodopsinas expresadas heterólogamente en cultivos celulares mostraron que Q mejoró el porcentaje y velocidad de regeneración de la opsina regenerada con 9-cis-retinal al compararla con 11-cis retinal. Se encontró que la Q mejora la compactación estructural al entorno de la base de Schiff de unión de la opsina y el cromóforo, evitando que el reactivo hidroxilamina entre fácilmente en el sitio de unión del retinal. Los experimentos funcionales de las muestras tratadas con 1 µM Q para la rodopsina nativa y mutante G90V regenerados con 9-cis-retinal mostraron una cinética sigmoidal claramente representativa de una coperatividad de unión. Además, la presencia de Q en la muestra final después de la inmunopurificación se demostró mediante HPLC-MS. Se ha demostrado mediante el uso de técnicas de biología molecular, métodos analíticos y en estudios computacionales, que algunos compuestos fenólicos, en particular la Q, pueden actuar como moduladores alostéricos de la 9-cis-rodopsina, efecto significativo en el caso del mutante G90V asociado a RP, donde las propiedades deletéreas de la mutación podrían ser parcialmente compensadas, y abre una nueva posibilidad de utilizar dichos compuestos en el tratamiento de neurodegeneraciones visual asociados a RP.
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Frankki, Sofia. "Association of organic compounds to dissolved and particulate natural organic matter in soils /." Umeå : Dept. of Forest Ecology, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200652.pdf.
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Hu, Shuting, та 胡舒婷. "Resorcinol-type phenolic compounds from natural sources inhibut α-MSH induced melanogenesis and UVA-induced DNA damage". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207207.
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Sunlight exposure is inevitable to all humans and UV radiation in the sunlight usually causes damages to the skin. Tanning, first appearing when UV injures occur, is a pigmentation process which can be considered as a natural defense mechanism of the organism. Melanin plays an important role in the prevention of the skin from harmful environmental factors such as UV radiation. However, the excess accumulation of melanin causes hyperpigmentation, which is associated with a number of unhealthy conditions including solar lentigines, melasma, freckles and post-inflammatory hyperpigmentation. Therefore, the development of safe and effective hypopigmenting agents is of great importance.
The depigmenting effects of oxyresveratrol and trans-dihydromorin, as well as moracenin D, sanggenon T, mulberrofuran G and kuwanon O, were investigated in murine b16f10 melanoma cell line and its synergetic non-tumor melanocyte melan-a cells. All these six resorcinol type phenolic compounds (RTPs) were found to reveal significant hypopigmenting effects in murine b16f10 melanoma cell line. Oxyresveratrol and Kuwanon O presented the greatest inhibition on melanin synthesis at low concentration with the suppression on tyrosinase activity. However, in melan-a cells, only oxyresveratrol, trans-dihydromorin, kuwanon O and sanggenon T decreased melanin content significantly. The subsequent mechanisms studies explained the difference. In b16 cells, all of these RTPs induced post-transcriptional degradations of MITF without suppressing its mRNA expression, leading to significant decreases of TRP-1 and TRP-2 production, while in melan-a cells, the levels of tyrosinase, as well as TRP-1and TRP-2 were suppressed by MITF downregulation at both transcription and translation level. Among these RTPs, kuwanon O induced the greatest suppression on the tyrosinase families via MITF down-regulation. Sanggenon T, trans-dihydromorin and oxyresveratrol also exhibited same action of mechanism with weaker activities than kuwanon O. Further evaluations in artificial skin model demonstrated the outstanding depigmenting effects of kuwanon O, sanggenon T and trans-dihydromorin. The inhibitory effect by oxyresveratrol is negligible. It can be therefore inferred that a non-tumor melanocytes system might be more suitable for screening depigmenting agents applied to normal skin cells. Hypopigmenting agents effective in b16 melanoma system may not be so effective on normal melanocytes. Meanwhile, according to the structure-activity relationships studies of theses RTPs, to screen or synthesize resorcinol flavonone derivatives with an isoprenyl group in the Diels-Alder substituent might be a novel approach for the search of potent hypopigmenting agents.
The photoprotective effects of these RTPs were also investigated, as UV radiation not only dominants the skin tanning level, but also induces genetic damage and mutations in the epidermal basal layer of human skin. Oxyresveratrol and kuwanon O were found to reveal photoprotective effects on human primary epidermal keratinocytes by enhancement of DNA repair after 4.32 J/cm2 UVA radiation. They exhibited suppressions on cellular ROS induced by UVA and H2O2. Nitrotyrosine levels enhanced by UVA irradiation were also suppressed by them. Moreover, oxyresveratrol even increased cell viability after 4.32 J/cm2 UVA radiation. The possibility of oxyresveratrol and kuwanon O for prevention of photocarcinogenesis in humans is a potential avenue for investigation.
In summary, the research contributed to the knowledge of depigmenting and photoprotective effects of resorcinol type phenolic compounds from natural sources. The findings support natural polyphenols as cosmetic ingredients or pharmaceutical composition in purpose of skin lightening or clinic therapy.<br>published_or_final_version<br>Biological Sciences<br>Doctoral<br>Doctor of Philosophy
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Oliveira, Lucillia Rabelo de. "Avaliação dos compostos fenólicos e das propriedades antioxidantes da polpa do pequi (Caryocar spp) processado e in natura." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-22052013-113150/.
Full textAbstract:
O pequi caracteriza-se por possuir expressiva quantidade de compostos fenólicos, que por apresentarem propriedades antioxidantes estão associados com a prevenção da formação de radicais livres. Além de ser consumido in natura, é também comumente consumido na forma processada. No entanto, sabe-se que os antioxidantes presentes nos vegetais podem ser afetados pela forma de processamento e provocam alterações dos teores de fenólicos totais (FT) bem como da sua atividade antioxidante. Este trabalho objetivou avaliar o teor de FT e as propriedades antioxidantes da polpa do pequi processado e in natura. Foram obtidos os extratos alcoólicos (EALC) e aquosos (EAQ), a partir de amostras liofilizadas de diversas polpas de pequi processado (em conserva) e também do in natura, bem como as frações de ácidos fenólicos livres (AFL), ésteres solúveis de ácidos fenólicos (AFS) e ésteres insolúveis de ácidos fenólicos (AFI) de pequi processado (CB1). Os EALC e EAQ, além dos líquidos provenientes das conservas (LC), foram avaliados quanto aos teores de FT, onde se verificou que os EAQ do pequi in natura, principalmente, e do processado tiveram um maior conteúdo de FT quando comparados aos EALC. Os LC, por sua vez, apresentaram valores médios ainda maiores que os EAQ. Com relação ao teor de FT das frações, a AFL se destacou diante da AFS e AFI. Os extratos, LC e frações foram avaliados quanto à atividade antioxidante in vitro pelo sistema β-caroteno/ácido linoléico e também pelo ensaio do radical DPPH• (2,2 difenil-1-picril-hidrazila). No primeiro, verificou-se que os EAQ e LC do pequi apresentaram maior atividade que os EALC. Foi observada ainda atividade elevada em todas as frações analisadas. No segundo ensaio pelo método do radical DPPH•, pode-se observar que os extratos aquosos do pequi in natura apresentaram maior atividade, enquanto que, no pequi processado, os extratos alcoólicos e os líquidos das conservas tiveram melhores resultados. Verificou-se também que a AFL possui atividade superior às outras frações. De uma maneira geral, os resultados do pequi processado foram inferiores aos do pequi in natura tanto em relação aos teores de FT como na atividade antioxidante. Verificando-se ainda, que isto se deve principalmente à perda dos FT da polpa, indicando que houve lixiviação destes compostos para os LC.<br>Pequi characterized by having a significant amount of phenolic compounds, that are related with its antioxidant properties that are associated with the prevention of free radicals. Besides being eaten fresh, it is also widely consumed in processed form. However, it is known that the antioxidants present in plants can be affected by processing form and cause changes in the levels of total phenolic content (FT) and the antioxidant activity. The objective of this study was to evaluate the content of phenolic compounds and the antioxidant properties of the pequi pulp processed and fresh. Were obtained the alcoholic (EALC) and aqueous (EAQ) extracts from lyophilized samples of various pulps pequi processed (canned) and also in nature, as well as the fractions of free phenolic acids (AFL), soluble esters of phenolic acids (AFS) and insoluble esters of phenolic acids (AFI) of processed pequi (CB1). The EALC and EAq, besides the liquid from the canned (LC) were evaluated for the levels of FT, where it was found that the EAQ of the pequi in nature, mainly, and of the processed had, in general, a higher content of FT compared to EALC. The LC, in turn have showed that even greater EAQ. Regarding the content of FT of the fractions, the AFL stood in front of the AFS and AFI. The extracts, LC and fractions were also evaluated for their antioxidant activity in vitro by the system β-caroteno/ linoleic acid and by test DPPH• (2,2-diphenyl-1-picryl hydrazyl). At first, it was found that the LC and EAQ of the pequi showed greater activity than the EALC. Still high activity was observed in all fractions analyzed. In the second test, we can observe that the EAQ of the pequi in nature showed greater activity, whereas in pequi processed, the EALC and LC had better results. It was also noted that the AFL has superior activity to other fractions. In general, the results of pequi processed were lower than in fresh pequi both in relation to content of FT as antioxidant activity. Verifying also, that this is mainly due to the loss of FT of the pulp, indicating that there was leaching of these compounds to the LC.
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Yan, Liang. "Tailoring of the activation process of carbonaceous adsorbentsfor improving their adsorption effectiveness." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396524230.
Full textBooks on the topic "Natural phenol compound"
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1951-, Shahidi Fereidoon, Ho Chi-Tang 1944-, and American Chemical Society. Division of Agricultural and Food Chemistry, eds. Phenolic compounds in foods and natural health products. American Chemical Society, 2005.
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Shahidi, Fereidoon, and Chi-Tang Ho, eds. Phenolic Compounds in Foods and Natural Health Products. American Chemical Society, 2005. http://dx.doi.org/10.1021/bk-2005-0909.
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Soto-Hernández, Marcos, Mariana Palma-Tenango, and Maria del Rosario Garcia-Mateos, eds. Phenolic Compounds - Natural Sources, Importance and Applications. InTech, 2017. http://dx.doi.org/10.5772/67213.
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Vassallo, Neville. Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases. Springer, 2015.
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Vassallo, Neville. Natural Compounds As Therapeutic Agents for Amyloidogenic Diseases. Springer London, Limited, 2015.
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Vassallo, Neville. Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases. Springer, 2016.
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Natural Phenolic Compounds for Health, Food and Cosmetic Applications. MDPI, 2020. http://dx.doi.org/10.3390/books978-3-03936-735-1.
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Zahari, Nur Zaida. Phenolic Compounds in the Environment Appearance and removal. Edited by Piakong Mohd Tuah and Mohammad Shaheen Khan. UMS Press, 2021. http://dx.doi.org/10.51200/phenoliccompoundsenvironment2020.
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This book, Phenolic Compounds in the Environment: Appearance and Removal is designed for researchers and postgraduates students in the environmental science field. It provides detailed information on phenolic compounds in the environment and methods of its removal for interested scientists. The topics are giving an insight view on future researches that possibly can be implemented by researchers in the laboratories as well as real environment to prevent the hazardous effects of phenolic compounds on human and nature.
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Phenolic Compounds in Foods and Natural Health Products (Acs Symposium Series). An American Chemical Society Publication, 2005.
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Chebil, Latifa, and Mohamed Ghoul. Enzymatic polymerization of phenolic compounds by oxidoreductases. Springer, 2012.
Find full textBook chapters on the topic "Natural phenol compound"
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Lattanzio, Vincenzo. "Phenolic Compounds: Introduction." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_57.
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Ignat, Ioana, Irina Volf, and Valentin I. Popa. "Analytical Methods of Phenolic Compounds." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_56.
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Pereira, David M., Patrícia Valentão, Mariana Sottomayor, Federico Ferreres, and Paula B. Andrade. "Phenolic Compounds in Catharanthus roseus." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_96.
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Yapici, Ismail. "Natural Antioxidants." In Natural Antioxidants and in Vitro Antioxidant Assays. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359333.2.
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Antioxidants are substances that provide protection against oxidants. They prevent the formation of oxidants and the damage they can cause to biomolecules. They extend the shelf life of foods. Antioxidants can be natural or synthetic. Some enzymes, phenolic compounds, flavonoids, carotenoids and some vitamins found in plants, fruits and vegetables are effective natural antioxidant compounds. There are also effective synthetic antioxidants such as BHA, BHT, TBHQ. However, it has been stated that synthetic antioxidants added to foods are harmful and their inclusion in foods is limited. Therefore, recent studies have focused on natural antioxidants.
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Routray, Winny, and Valérie Orsat. "Preparative Extraction and Separation of Phenolic Compounds." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_55.
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Šovljanski, Olja, Tara Budimac, Ana Tomić, Dragoljub Cvetković, and Aleksandra Ranitović. "Kombucha As a Functional Beverage Rich in Phenolic Compounds." In Natural Products. Springer Berlin Heidelberg, 2025. https://doi.org/10.1007/978-3-642-36202-6_242-1.
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Kundu, Sweta, Suvodeep Saha, Mrinmoy Dey, Agnik Mukherjee, Suparna Ghosh, and Avik Acharya Chowdhury. "Defining Anticancer Potential of Phenolic Compounds from Piper betel." In Natural Products. Springer Berlin Heidelberg, 2025. https://doi.org/10.1007/978-3-642-36202-6_244-1.
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Bogdanov, Milen G., and Ivan Svinyarov. "Extraction of Natural Phenolic Compounds with ABS." In Green Chemistry and Sustainable Technology. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-52875-4_8.
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Panzella, Lucia, and Alessandra Napolitano. "Powering the Activity of Natural Phenol Compounds by Bioinspired Chemical Manipulation." In ACS Symposium Series. American Chemical Society, 2018. http://dx.doi.org/10.1021/bk-2018-1286.ch022.
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Yilmaz, Mustafa Abdullah, and Oguz Cakir. "Salvia (Sage) Species, a Game-Changer Bioactive Plant: Focus on Antioxidant Properties." In Natural Antioxidants and in Vitro Antioxidant Assays. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359333.4.
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The demand for natural, health-oriented food additives and components has increased, with plant-based foods rich in phytochemicals like phenolic compounds being beneficial for human health. Salvia species, the largest plant family in the Lamiaceae, contain over nine hundred species, including sage, which has numerous beneficial uses and biological properties. Sage extracts have shown antioxidant, hypoglycemic, hypolipidemic, antitumor, anticholinesterase, antimicrobial, and liver-protective properties. S. officinalis L. has been suggested to have an anti-radical effect against uranium toxicity. Sage essential oil (EO) has antibacterial, antifungal, and free radical scavenging properties. S. miltiorrhiza has been given special attention for treating viral illnesses, with quinoone diterpenes being the most intriguing. Antioxidant activity evaluation techniques have evolved over the past decade, with chemical assays and novel detection technologies replacing earlier approaches. In vitro chemical tests, such as hydrogen atom transfer (HAT) and single electron transfer (SET) procedures, are used to assess antioxidant capacity. Electron transfer (ET) assays measure antioxidant activity by transferring electrons and lower metallic ions, carbonyl groups, and free radicals. Mixed tests (HAT/SET) determine the total antioxidant capacity (TAC) of a compound or extract. In vivo animal experiments are used to assess the antioxidant activity of natural extracts. Future research should focus on sage’s antioxidant properties, its mode of action, and the varying compositions of different species.
Conference papers on the topic "Natural phenol compound"
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Stepacheva, Antonina, Mariia Markova, Oleg Manaenkov, Elena Shimanskaya, and Valentina Matveeva. "SAWDUST LIQUIEFACTION OVER SCHUNGITE-BASED CATALYST." In 24th SGEM International Multidisciplinary Scientific GeoConference 24. STEF92 Technology, 2024. https://doi.org/10.5593/sgem2024/4.1/s17.26.
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The deep processing of lignocellulose feedstock (including waste from the woodworking industry, agriculture, and agro-industry) allowing the high-added value products to be obtained is one of the key scientific problems. Lignocellulose biomass is a potential feedstock for the production of heat, electricity, fuel, chemicals, and other bioderived products. The liquefaction is considered to be one of the most promising ways to convert lignocellulose biomass into liquid fuels. During the liquefaction, lignocellulose biomass can be efficiently converted into important base compounds, such as furfural, 5-hydroxymethylfurfural, levulinic acid and its esters, ?-pentylactone, alkyl glycosides, and phenols. The search of effective catalysts for liquefaction is the main task for the development of the technology for obtaining liquid fuels from biomass. In this work, the liquefaction of the wood waste in the presence of a heterogeneous catalyst was studied. The novel Ni-containing catalyst supported on the natural carbonaceous material was used in this work. The influence of the reaction parameters on the biomass conversion, and product yield was estimated. The effect of the solvent, reaction temperature, hydrogen pressure, and preliminary treatment of biomass was analysed. It was shown that the developed catalyst allows the feedstock conversion to be about 90 wt. % for the non-hydrolysed sawdust. The preliminary hydrolysis of the feedstock increased the conversion up to 95 wt. %. The composition of the liquid products were presented by the products of the hydrolysis of cellulose, hemicelluloses, and lignin, as well as the polyols, 5-hydroxymethylfurfural, aromatics, and cyclic compounds.
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Zhang, Yong. "One Hundred Percent Solids Ambient Cure Liquid Pipe Coating with Excellent Cathodic Disbondment Results." In CORROSION 2019. NACE International, 2019. https://doi.org/10.5006/c2019-12823.
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Absrract Epoxy coatings have long been the work horse for Maintenance and Protective Coatings (M&PC) due to their excellent corrosion resistance, excellent heat and chemical resistance, good mechanical properties, as well as excellent adhesion to various substrates1. The epoxy resins are typically based on bisphenol A diglycidyl either (BADGE), bisphenol F diglycidyl either, and epoxy phenol novolacs2; and they are usually very viscous in nature and therefore require a high volume of solvent to reduce the viscosity for easier application. There is a strong desire among participants throughout the M&PC value chain to reduce the emission of volatile organic compounds (VOCs) from these coatings. One hundred percent solids coatings are one route to meet that objective. Olin Epoxy has designed a 100% solids formulated epoxy and hardener system to meet this need. This paper documents the performance of this system against a well-known commercial benchmark for external pipe coating applications. Fully pigmented two component liquid pipe coating formulas will be described and modifications of the formula to meet different volume mixing ratios will also be discussed. Various performance aspects of experimental and commercial benchmarks will be compared, including pot life, Konig hardness, low temperature curing performance, dry time, and cathodic disbondment (CD) at elevated temperatures. CD test results at dry film thickness (DFT) above 30 mils (750 microns) and less than 20 mils (500 microns) are also discussed. The range of conditions under which this high solids system can be applied to achieve good performance will also be summarized.
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Todorović, Jovana D., Aleksandra D. Vesić, Nevena N. Petrović, and Marijana M. Kosanić. "Edible mushrooms as promising antioxidants." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.300t.
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Antioxidant activity of the acetone extracts of the mushrooms Macrolepiota procera and Chlorophyllum rhacodes has been screened in vitro by using different methods (DPPH radical scavenging and reducing power assay), and also it has been determined the total phenolic compounds as total flavonoid content. The research findings indicate that the acetone extract of M. procera demonstrated superior antioxidant activities when compared to C. rhacodes. Similarly, the mushroom M. procera displayed a more pronounced effect on reducing power. In addition, the total content of phenol and flavonoid in extracts were determined as pyrocatechol equivalent, and as rutin equivalent, respectively. A higher content of total phenols and flavonoids was detected in the extract of M. procera. The strong relationships between total phenolic and flavonoid contents and the antioxidative activities of tested extracts imply that these compounds have a significant impact on antioxidant activity. The present study highlights that the tested mushroom species exhibit potent antioxidant properties and can be regarded as valuable sources of natural antioxidants.
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Tschanner, Julius, Jinchang Ren, Frances Jack, Stephen Marshall, and Huimin Zhao. "Employing NIR-SWIR hyperspectral imaging to predict the smokiness of scotch whisky." In OCM 2017 - 3rd International Conference on Optical Characterization of Materials. KIT Scientific Publishing, 2017. http://dx.doi.org/10.58895/ksp/1000063696-1.
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Scotch Whisky makes a significant contribution to the UK’s food and drinks export. The flavour of this high quality spirit is derived naturally from the whisky making process, with smoky aromas being a key character of certain Scotch whiskies. The level of smokiness is determined by the amount of phenolic compounds in the spirit. Phenols are introduced by exposing the barley malt to peat smoke during the kilning process. The current techniques to determine the levels of phenols, such as High Performance Liquid Chromatography (HPLC), are time consuming as they require distillation of the malt prior to analysis. To speed up this process and enable real-time detection before processing, the possibilities of Near-infrared to Short-wave-infrared (NIR-SWIR) Hyperspectral Imaging (HSI) to detect these phenols directly on malted barley are explored. It can be shown that via regression analysis, various levels of phenol concentration used as working levels for whisky production could be estimated to a satisfying degree. To further optimise industrial application, a hyperspectral band selection algorithm is applied that yields good results and reduces computational cost and may open possibilities to employ multispectral rather than hyperspectral cameras in future applications.
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Rosu, Magdalena, and Monica Dragomirescu. "BIOACTIVE COMPOUNDS FROM HORSERADISH FOR BIOTECHNOLOGICAL APPLICATIONS." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023v/6.2/s25.07.
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The horseradish (Armoracia rusticana) is a root vegetable that belongs to the botanical family Brassicaceae and due to the high content of bioactive compounds, it has of great interest in many biotechnological fields. The high content of polyphenols, phenols, flavonoids, vitamin C and detoxification enzymes makes horseradish to have a great antioxidant potential and positive effects on the health, being used from ancient times as medicinal plant. The abundance of minerals, vitamins and dietary fibre make horseradish worth to be considered as a natural functional food with a high energy value. In addition to all these biologically active compounds with specific properties for the pharmaceutical and food industry, peroxidase from horseradish (HRP) is known as a green biocatalyst for degradation of wastewater containing phenol. For economical efficient biocatalysts processes, and for a better stability of HRP in the harsh conditions of phenol degradation, immobilized enzymes are frequently used. All the immobilization methods have proven to be effective for HRP, starting to binding methods (physical adsorption, covalent binding), crosslinking, encapsulation and entrapment in porous biomaterials. The immobilized enzymatic preparations showed high specificity and selectivity and very good efficiency in removing the hazardous substants. HRP in immobilized form was also used to develop smart biosensors for detection of pollutants from wastewaters resulted from industrial processes.
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Ohindovschi, Angelica, and Maria Cojocaru-Toma. "Identification of phenolic compounds from extract of Galium verum." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab21.
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The species Galium verum has a long history as a traditional healing herb and attracted attention for intense investigation in recent years as it proves to be a safe, affordable and effective natural health remedy as a choleretic, diuretic or spasmolytic [1]. There is detailed research showing a complex and rich content of phytochemicals in the flowers and leaves of G. verum, with the highest total composition of phenols and flavonoids [2]. For the determination of phenolic compounds, the plant extract was obtained from Galii veri herba, collected during the flowering period and treated with 60 % hydro-ethanol solution (ratio of 1:10). The extraction was performed using a water bath, followed by the removal of solvent with rotary evaporator Laborota 4011. Identification of phenolic compounds was carried out by thin layer chromatography (TLC) in three systems: Ist system– butanol-glacial acetic acid-water (4:1:2), IInd system– chloroform-ethyl alcohol (9:1) and IIIrd system–formic acid-water-ethyl acetate (6:9:90). Table 1. Identification of phenolic compounds in extract of Galii veri herba by TLC.In the chromatographic study of the extract from G.veri herba, in all three systems, identified compounds of phenolic nature including four hydroxycinnamic acids (caffeic, chlorogenic, p-coumaric and gallic) and six flavonoids (rutosid, hyperosid, quercetin, isoquercetin, apigenin, quercitrin) with a more successful separation in the chloroform-ethyl alcohol system (9:1). The extract of Galii veri herba is rich in phenolic compounds and can be used for further preclinical and clinical studies.
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Popusoi, Ana, Nicanor Barba, and Aurelian Gulea. "Synthesis of 1,3-Phenyl(Pyridyl)propenones with thiosemicarbazidic groups." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab03.
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The bibliographic study of chalcones of the type 1,3-aryl(heteryl)propen-2-one with thiosemicarbazidic 4- and 1,4-disubstituted and thisemicarbazonic groups respectively gives us the information that they have a wide spectrum of biological activity, but methods of their synthesis are less described in the literature, and they became our object of study. 4,5-Dihydro-1-H-(pyrazol-3-yl)phenylhydrazinecarbothioamides 3a and 3b were obtained according to the following scheme:Reagents and reaction conditions: i, ii) 2-Py, 25oC – 24h, 90-95oC – 3h, 77-82%; iii) DMF, CH3COOH, 70-80oC, 2-3h, 60-63%. Figure 1. Synthesis of chalcone derivatives 3a, 3b, 4a and 4b.Initially N,N-dimethylthioureas 1a and 1b with hydrazine hydrate from hydrazones in pyridine at room temperature, which without being isolated upon heating cyclize to pyrazole derivatives (Fig. 1.) as described in the literature, and in parallel, dimethylamine is substituted by the hydrazine group [1] with the formation of compounds 3a and 3b, with a yield of 77%. Compound 3a was also obtained by an alternative route from isothiocyanatophenylpropen-2one 2a and hydrazine hydrate at room temperature, then on heating in pyridine (Fig. 1.). It is possible to from the same intermediates, which turn in to the finished product 3a, the yield is 82%. Compounds 4a and 4b were obtained from products 3a and 3b by boiling in ethanol with 2-pyridinecarboxyaldehyde. The antiproliferative activity of N-(4-(5-(pyridine-2-yl)-4,5dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridine-2-ylmethylene)hydrazinecarbotioamide towards HL-60 leukemia cells were patented [2].
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Tomenko, D., E. Aksenov, and Lyudmila Novikova. "PHENOLIC COMPOUNDS OF CONIFEROUS TREES." In Modern machines, equipment and IT solutions for industrial complex: theory and practice. FSBE Institution of Higher Education Voronezh State University of Forestry and Technologies named after G.F. Morozov, 2021. http://dx.doi.org/10.34220/mmeitsic2021_351-356.
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The paper discusses the classification, structure and properties of natural phenolic compounds found in conifers wood species of Russia. The reasons for the variety of detected phenolic compounds (more than 2000) are considered, including the type and conditions of plant growth, environmental factors, as well as methods for extraction of substances. Coniferous extractives include monomeric, dimeric and polymeric phenolic compounds in bound and free form, and their content differs significantly for various species and parts of a woody plant. Depending on the polarity of the solvent used (water, petroleum ether, dimethyl ether, ethyl acetate, acetone, etc.), the yield, chemical composition and structure of the extracted phenolic compound change. It was shown that bark extracts of Larch and Fir contain the most phenolic acids and extractive substances than Pine, Cedar and Spruce, while the content of polar substances is higher in needles, and non- polar substances in plant shoots. Phenolic compounds are secondary plant metabolites, exhibiting fungicidal, virucidal and strong antioxidant effects, that make them a valuable basis for the creation of drugs.
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Vieitez Osorio, Ignacio, Adriana Gambaro, Cecilia Dauber, Elena Ibanez, Laura Gonzalez, and Tatiana Carreras. "Supercritical extracts from olive leaves as natural antioxidants: extraction optimization, characterization and evaluation." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/dtog7326.
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Olive leaves (OL) are considered a potential source of bioactive compounds mainly due to its high content of polyphenols, widely known as natural antioxidants. The objective of this study was to optimize supercritical fluid extraction conditions from OL in order to obtain natural extracts with high antioxidant activity. OL (belong to the Arbequina cultivar) were collected from a local producer (Uruguay) and subjected to a drying and milling (1 mm particle size) pre-treatment. Supercritical fluid extractions were carried out using a laboratory-built system equipped with a 25 mL stainless steel vessel filled with 10 g of OL. A total of 10 extractions were carried out following a Central Composite Design in which the two independent variables considered were: extraction temperature (40–60 °C) and extraction pressure (150-350 bar). In all cases, extraction solvent was CO2 with 10% of ethanol as modifier. A constant flow rate of 0.5 L/min CO2 was set and each run was finished when 100 L of CO2 were measured in the flow totalizer. Extraction yield (% wt), total phenolic content (Folin-Ciocalteau) and antioxidant activity (ABTS+. assay) of the extracts were considered as response variables. Extraction yield was positively correlated with temperature and pressure, while total phenolic content and antioxidant activity were negatively correlated with temperature. Phenolic content of the extracts varied from 22.9 to 53.6 mg GAE/g. For the extract obtained at optimal conditions, the identification of individual polyphenols was performed by RP/HPLC-Q-TOF MS/MS, being phenolic acids, simple phenols and secoiridoids the most abundant compounds. Finally, oxidative stability of canola oil with or without the incorporation of 250 ppm of some extracts was assessed during five weeks of storage at 60°C. Peroxide, K232, K270, and Rancimat values, besides tocopherol content were determined. Results obtained reinforce the use of supercritical fluid technology to obtain antioxidants compounds from natural sources.
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Radovanović, Marko, Ignjat Filipović, Maja Đukić, Marija Ristić, Ivan Jakovljević, and Zoran D. Matović. "Molecular docking study of ruthenium-p-cymene complexes with isothiazole derivatives as SARS-CoV-2 main protease inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.387r.
Full textAbstract:
Since proper treatment for COVID-19 still has not been developed, exploration of novel options is required. Activities of different metal complexes, promising results gained from examining different thiazole derivatives, and research in the field of natural products like p-cymene, produced an idea to test piano stool ruthenium p-cymene complexes with isothiazole derivatives as ligands. In silico methods are often used as the first step in a series of experiments during the development of new drugs, and docking simulations are a quick way to determine the feasibility of novel compounds as potential inhibitors of target enzymes. Existing compounds of ruthenium with published crystal structures were tested against the main protease of SARS-CoV-2. All of the tested compounds show a potential ability to bind to the target enzyme, while the compound with phenyl and morpholinyl substituents in isothiazole ligand shows the best activity among tested compounds. Authors feel confident that further research on this topic will yield compounds with even better potential activities against the main protease of the SARS-CoV-2.
Reports on the topic "Natural phenol compound"
1
Choudhary, Ruplal, Victor Rodov, Punit Kohli, John D. Haddock, and Samir Droby. Antimicrobial and antioxidant functionalized nanoparticles for enhancing food safety and quality: proof of concept. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597912.bard.
Full textAbstract:
General concept. The reported 1-year study tested the feasibility ofpreparing antimicrobial and antioxidant nanoparticlesfunctionalized with natural phenolic compounds, as a first step to reach the ultimate goal - improving safely and quality of foods by developing novel antimicrobial and antioxidant food-contacting materials. The secondary objectives of the study were (a) selecting the most promising phenoliccompounds, (b) building nanoparticles with the selected phenolicgrafted on their Surface, and (c) testing antimicrobial and antioxidant properties of these particles. The study was expected to provide a " go/no go" decision as concerning the prospects of phenolic- bound nanoparticles as antimicrobial and antioxidant agents. Results. In course of the feasibility study, curucminwas chosen as the most promising phenoliccompound due to its high antibacterial activity exceeding other tested compounds by at leas one order of magnitude. Lipsome-typephospholipid/polydiacetylene(PDA) nanoparticlesfunctionalizedwith curcuminwere successfully built. The pitfall of limited curcumin amount that could be covalently bound to theparticle surface was circumvented by inclusion of curcunun in the liposome body. It was suggested onthe basis of fluorescence spectroscopy that curcuminwas bound by hydrophobic forces in the bi1ayer periphery of the Liposomesand therefore mightexert a contact effect on microorganisms. The curcumin functionalizednanoparticles(CFN) were shown to have a strong bactericidal activity towards both Gram-negative (E. coli) and Gram-positive (B. ce,·e11s) bacteria, but only limited effect against yeast. Furthermore, beyond the originallyplanned objectives, preliminary trials showed that CFN could be bound to silanized glass surface rendering aנבtiנnicrobial activity to the glass. Tnaddition, the particles showed antioxidantcapacity. Tberefore, it ,vas co11cluded tlוattlוeaims of tlוefeasibility study bad been successfully reached an